<?xml version="1.0"?>
<!-- - EDGAR Ease Plus 1.0                                   07/25/03  TT    -->
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType>
   <periodOfReport>2003-12-16</periodOfReport>
   <notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000725058</issuerCik>
        <issuerName>CYTOGEN CORP</issuerName>
        <issuerTradingSymbol>CYTO</issuerTradingSymbol>
   </issuer>
   <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001211252</rptOwnerCik>
            <rptOwnerName>BECKER MICHAEL D</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CYTOGEN CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>650 COLLEGE ROAD EAST CN-5308 SUITE 3100</rptOwnerStreet2>
            <rptOwnerCity>PRINCETON</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08540</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
         <isDirector>0</isDirector>
         <isOfficer>1</isOfficer>
         <isTenPercentOwner>0</isTenPercentOwner>
         <isOther>0</isOther>
         <officerTitle>President and CEO</officerTitle>
      </reportingOwnerRelationship>
   </reportingOwner>
 <derivativeTable>
   <derivativeTransaction>
      <securityTitle>
         <value>Option to Purchase Shares of Common Stock</value>
      </securityTitle>
      <conversionOrExercisePrice>
         <value>10.9</value>
      </conversionOrExercisePrice>
      <transactionDate>
         <value>2003-12-16</value>
      </transactionDate>
      <transactionCoding>
         <transactionFormType>4</transactionFormType>
         <transactionCode>A</transactionCode>
         <equitySwapInvolved>0</equitySwapInvolved>
      </transactionCoding>
      <transactionAmounts>
         <transactionShares>
           <value>10000</value>
         </transactionShares>
         <transactionPricePerShare>
           <value>0</value>
         </transactionPricePerShare>
         <transactionAcquiredDisposedCode>
           <value>A</value>
         </transactionAcquiredDisposedCode>
      </transactionAmounts>
      <exerciseDate>
         <value>2004-12-16</value>
            <footnoteId id="F1"/>
      </exerciseDate>
      <expirationDate>
         <value>2013-12-16</value>
      </expirationDate>
      <underlyingSecurity>
         <underlyingSecurityTitle>
           <value>Common Stock</value>
         </underlyingSecurityTitle>
         <underlyingSecurityShares>
           <value>10000</value>
         </underlyingSecurityShares>
      </underlyingSecurity>
      <postTransactionAmounts>
         <sharesOwnedFollowingTransaction>
           <value>10000</value>
         </sharesOwnedFollowingTransaction>
      </postTransactionAmounts>
      <ownershipNature>
         <directOrIndirectOwnership>
           <value>D</value>
         </directOrIndirectOwnership>
      </ownershipNature>
   </derivativeTransaction>
 </derivativeTable>
   <footnotes>
      <footnote id="F1"> Such options will vest as follows:  (i) 3,334 on 12/16/2004; (ii) 3,333 on 12/16/2005; and (iii) 3,333 on 12/16/2006.</footnote>
   </footnotes>
   <ownerSignature>
      <signatureName>/s/ Michael D. Becker</signatureName>
      <signatureDate>2004-01-06</signatureDate>
   </ownerSignature>
</ownershipDocument>
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X0201
4
2003-12-16
0
0000725058
CYTOGEN CORP
CYTO
0001211252
BECKER MICHAEL D
C/O CYTOGEN CORPORATION
650 COLLEGE ROAD EAST CN-5308 SUITE 3100
PRINCETON
NJ
08540
0
1
0
0
President and CEO
Option to Purchase Shares of Common Stock
10.9
2003-12-16
4
A
0
10000
0
A
2004-12-16
2013-12-16
Common Stock
10000
10000
D
Such options will vest as follows:  (i) 3,334 on 12/16/2004; (ii) 3,333 on 12/16/2005; and (iii) 3,333 on 12/16/2006.
/s/ Michael D. Becker
2004-01-06