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        <issuerName>THERMO FISHER SCIENTIFIC INC.</issuerName>
        <issuerTradingSymbol>TMO</issuerTradingSymbol>
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            <rptOwnerName>Malus Alan J</rptOwnerName>
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            <rptOwnerCity>WALTHAM</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>024549046</rptOwnerZipCode>
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            <officerTitle>Senior Vice President</officerTitle>
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    <footnotes>
        <footnote id="F1">Received in exchange for 12,000 shares of Fisher Scientific International Inc. common stock in connection with the merger of Thermo Fisher Scientific Inc. (formerly known as Thermo Electron Corporation), Trumpet Merger Corporaton and Fisher Scientific International Inc., (&quot;FSH&quot;) (the &quot;Merger&quot;).  On the effective date of the Merger, the closing price of FSH's common stock was $86.58 per share, and the closing price of TMO's common stock was $43.37 per share.</footnote>
        <footnote id="F2">Received in exchange for 6,600 Restricted Stock Units accrued under FSH's 2005 Equity and Incentive Plan.  The Restricted Stock Units were settled pursuant to the Merger for 2.0 shares of TMO common stock on the effective date of the Merger.</footnote>
        <footnote id="F3">Received in exchange for 10,800 Restricted Stock Units accrued under FSH's 2005 Equity and Incentive Plan.  The Restricted Stock Units were settled pursuant to the Merger for 2.0 shares of TMO common stock on the effective date of the Merger.</footnote>
        <footnote id="F4">Received in the Merger in exchange for an employee stock option to acquire 18,000 shares of FSH common stock for $39.25 per share.</footnote>
        <footnote id="F5">Received in the Merger in exchange for an employee stock option to acquire 15,000 shares of FSH common stock for $30.00 per share.</footnote>
        <footnote id="F6">Received in the Merger in exchange for an employee stock option to acquire 10,002 shares of FSH common stock for $28.40 per share.</footnote>
        <footnote id="F7">The option vests in five equal annual installments beginning on November 9, 2007.</footnote>
        <footnote id="F8">Received in the Merger in exchange for an employee stock option to acquire 18,700 shares of FSH common stock for $61.35 per share.</footnote>
        <footnote id="F9">14,560 options are currently exercisable; 14,560 options are exercisable on 12/31/06; and 7,280 options are exercisable on 12/31/07.</footnote>
        <footnote id="F10">Received in the Merger in exchange for an employee stock option to acquire 18,200 shares of FSH common stock for $64.60 per share.</footnote>
        <footnote id="F11">15,336 options are currently exercisable; 15,336 options are exercisable on 12/31/06; and 7,668 options are exercisable on 12/31/07.</footnote>
        <footnote id="F12">Received in the Merger in exchange for an employee stock option to acquire 19,170 shares of FSH common stock for $62.61 per share.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>By: Barbara J. Lucas, Attorney-in-Fact for Alan J. Malus</signatureName>
        <signatureDate>2006-11-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
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X0202
4
2006-11-09
0
0000097745
THERMO FISHER SCIENTIFIC INC.
TMO
0001380163
Malus Alan J
81 WYMAN STREET
P.O. BOX 9046
WALTHAM
MA
024549046
0
1
0
0
Senior Vice President
Common Stock
2006-11-09
4
A
0
24000
A
24000.00
D
Common Stock
2006-11-09
4
A
0
13000
0
A
37000.00
D
Common Stock
2006-11-09
4
A
0
13200
A
50200.00
D
Common Stock
2006-11-09
4
A
0
21600
A
71800.00
D
Common Stock
2006-11-09
4
F
0
3909
43.37
D
67891.00
D
Stock Option (Right to Buy)
19.63
2006-11-09
4
A
0
36000
A
2006-11-09
2008-09-26
Common Stock
36000.00
36000.00
D
Stock Option (Right to Buy)
15.00
2006-11-09
4
A
0
30000
A
2006-11-09
2011-05-03
Common Stock
30000.00
30000.00
D
Stock Option (Right to Buy)
14.20
2006-11-09
4
A
0
20004
A
2006-11-09
2013-01-27
Common Stock
20004.00
20004.00
D
Stock Option (Right to Buy)
43.37
2006-11-09
4
A
0
151400
0
A
2013-11-09
Common Stock
151400.00
151400.00
D
Stock Option (Right to Buy)
30.68
2006-11-09
4
A
0
37400
A
2006-11-09
2015-03-07
Common Stock
37400.00
37400.00
D
Stock Option (Right to Buy)
32.30
2006-11-09
4
A
0
36400
A
2015-07-25
Common Stock
36400.00
36400.00
D
Stock Option (Right to Buy)
31.31
2006-11-09
4
A
0
38340
A
2015-12-19
Common Stock
38340.00
38340.00
D
Received in exchange for 12,000 shares of Fisher Scientific International Inc. common stock in connection with the merger of Thermo Fisher Scientific Inc. (formerly known as Thermo Electron Corporation), Trumpet Merger Corporaton and Fisher Scientific International Inc., ("FSH") (the "Merger").  On the effective date of the Merger, the closing price of FSH's common stock was $86.58 per share, and the closing price of TMO's common stock was $43.37 per share.
Received in exchange for 6,600 Restricted Stock Units accrued under FSH's 2005 Equity and Incentive Plan.  The Restricted Stock Units were settled pursuant to the Merger for 2.0 shares of TMO common stock on the effective date of the Merger.
Received in exchange for 10,800 Restricted Stock Units accrued under FSH's 2005 Equity and Incentive Plan.  The Restricted Stock Units were settled pursuant to the Merger for 2.0 shares of TMO common stock on the effective date of the Merger.
Received in the Merger in exchange for an employee stock option to acquire 18,000 shares of FSH common stock for $39.25 per share.
Received in the Merger in exchange for an employee stock option to acquire 15,000 shares of FSH common stock for $30.00 per share.
Received in the Merger in exchange for an employee stock option to acquire 10,002 shares of FSH common stock for $28.40 per share.
The option vests in five equal annual installments beginning on November 9, 2007.
Received in the Merger in exchange for an employee stock option to acquire 18,700 shares of FSH common stock for $61.35 per share.
14,560 options are currently exercisable; 14,560 options are exercisable on 12/31/06; and 7,280 options are exercisable on 12/31/07.
Received in the Merger in exchange for an employee stock option to acquire 18,200 shares of FSH common stock for $64.60 per share.
15,336 options are currently exercisable; 15,336 options are exercisable on 12/31/06; and 7,668 options are exercisable on 12/31/07.
Received in the Merger in exchange for an employee stock option to acquire 19,170 shares of FSH common stock for $62.61 per share.
By: Barbara J. Lucas, Attorney-in-Fact for Alan J. Malus
2006-11-14