<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType>
	<periodOfReport>2003-06-30</periodOfReport>
	<notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000732485</issuerCik>
        <issuerName>GENZYME CORP</issuerName>
        <issuerTradingSymbol>GENZ</issuerTradingSymbol>
	</issuer>
	<reportingOwner>
		<reportingOwnerId>
            <rptOwnerCik>0001201254</rptOwnerCik>
            <rptOwnerName>COLLIER EARL M JR</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
			<isDirector>0</isDirector>
			<isOfficer>1</isOfficer>
			<isTenPercentOwner>0</isTenPercentOwner>
			<isOther>0</isOther>
			<officerTitle>Executive Vice President</officerTitle>
		</reportingOwnerRelationship>
	</reportingOwner>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Biosurgery common stock (GZBX)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
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			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
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			</transactionShares>
			<transactionValue>
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			</transactionValue>
			<transactionAcquiredDisposedCode>
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			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>0</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
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			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Biosurgery common stock (GZBX)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
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		<transactionAmounts>
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			</transactionShares>
			<transactionValue>
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			</transactionValue>
			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
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			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value>By 401(k)</value>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
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			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
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		<transactionAmounts>
			<transactionShares>
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			</transactionShares>
			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
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			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
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			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			</transactionShares>
			<transactionValue>
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			<transactionAcquiredDisposedCode>
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			</transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
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			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
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			<natureOfOwnership>
				<value/>
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		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>273</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value>By 401(k)</value>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Molecular Oncology common stock (GZMO)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
		</transactionCoding>
		<transactionAmounts>
			<transactionShares>
				<value>1076</value>
			</transactionShares>
			<transactionValue>
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			</transactionValue>
			<transactionAcquiredDisposedCode>
				<value>D</value>
			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>0</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Molecular Oncology common stock (GZMO)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			</transactionShares>
			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
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			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value>By 401(k)</value>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery ISO stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>32.44</value>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
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		<transactionAmounts>
			<transactionShares>
				<value>5028</value>
				<footnoteId id="F2"/>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<exerciseDate>
			<value>1997-01-30</value>
			<footnoteId id="F3"/>
		</exerciseDate>
		<expirationDate>
			<value>2007-01-30</value>
		</expirationDate>
		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Biosurgery common stock (GZBX)</value>
			</underlyingSecurityTitle>
			<underlyingSecurityShares>
				<value>5028</value>
			</underlyingSecurityShares>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>0</value>
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		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
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			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</derivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>32.44</value>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
		</transactionCoding>
		<transactionAmounts>
			<transactionShares>
				<value>4469</value>
				<footnoteId id="F2"/>
			</transactionShares>
			<transactionValue>
				<value>0</value>
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			<transactionAcquiredDisposedCode>
				<value>D</value>
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		<exerciseDate>
			<value>2006-07-30</value>
		</exerciseDate>
		<expirationDate>
			<value>2007-01-30</value>
		</expirationDate>
		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Biosurgery common stock (GZBX)</value>
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		<postTransactionAmounts>
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		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
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			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</derivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>29.46</value>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
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		<transactionAmounts>
			<transactionShares>
				<value>3883</value>
				<footnoteId id="F2"/>
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			<transactionValue>
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		<exerciseDate>
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			<footnoteId id="F4"/>
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		<expirationDate>
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		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Biosurgery common stock (GZBX)</value>
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		<postTransactionAmounts>
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		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
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			<natureOfOwnership>
				<value/>
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	</derivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
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		<conversionOrExercisePrice>
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		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
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		<transactionAmounts>
			<transactionShares>
				<value>1829</value>
				<footnoteId id="F2"/>
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			<transactionValue>
				<value>0</value>
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			<transactionAcquiredDisposedCode>
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		<exerciseDate>
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		<expirationDate>
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			<underlyingSecurityTitle>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>0</value>
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		<ownershipNature>
			<directOrIndirectOwnership>
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			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
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	</derivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
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		<conversionOrExercisePrice>
			<value>23.12</value>
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		<transactionDate>
			<value>2003-06-30</value>
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		<transactionCoding>
			<transactionFormType>4</transactionFormType>
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		<transactionAmounts>
			<transactionShares>
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				<footnoteId id="F2"/>
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			<transactionValue>
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		<exerciseDate>
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			<footnoteId id="F5"/>
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		<expirationDate>
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			<underlyingSecurityTitle>
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		<ownershipNature>
			<directOrIndirectOwnership>
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			<natureOfOwnership>
				<value/>
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	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
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		<conversionOrExercisePrice>
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		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
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			<transactionShares>
				<value>95445</value>
				<footnoteId id="F2"/>
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		<exerciseDate>
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			<footnoteId id="F6"/>
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				<value/>
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	<derivativeSecurity>
		<securityTitle>
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		<transactionDate>
			<value>2003-06-30</value>
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		<transactionAmounts>
			<transactionShares>
				<value>100000</value>
				<footnoteId id="F2"/>
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		<ownershipNature>
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			<natureOfOwnership>
				<value/>
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	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
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			<value>2003-06-30</value>
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				<footnoteId id="F2"/>
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		<ownershipNature>
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		<footnote id="F1">On June 30, 2003 all outstanding shares of Genzyme Biosurgery and Genzyme Molecular stock were exchanged for shares of Genzyme General Stock.  Genzyme Biosurgery shareholders received .04914 of a share of Genzyme General stock for each Biosurgery share and Genzyme Molecular Oncology shareholders received .05653 of a share of Genzyme General stock for each Molecular Oncology share.</footnote>
		<footnote id="F2">On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.</footnote>
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		<footnote id="F4">Options vest 20% on October 16, 1997 and in 20% annual increments beginning May 16, 1998.</footnote>
		<footnote id="F5">Options were granted with an exercise price 100% above fair market value, and vest in 1/3 increments on each of Janary 25, 2001, 2002 and 2003.</footnote>
		<footnote id="F6">Options vest 20% on August 26, 1999 and in 20% annual increments beginning May 26, 2000.</footnote>
		<footnote id="F7">Options vest in 25% annual increments on July 17, 2001, 2002, 2003 and 2004.</footnote>
		<footnote id="F8">Options vest 20% on 8/26/1999 and in 20% annual increments beginning May 26, 2000.</footnote>
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0000732485
GENZYME CORP
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COLLIER EARL M JR
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1
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0
Executive Vice President
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2003-06-30
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J
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D
0
D
Genzyme Biosurgery common stock (GZBX)
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0
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A
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Genzyme General common stock (GENZ)
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J
0
60
0
A
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D
Genzyme General common stock (GENZ)
2003-06-30
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J
0
22
0
A
273
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By 401(k)
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0
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0
D
0
D
Genzyme Molecular Oncology common stock (GZMO)
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J
0
7
0
D
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By 401(k)
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2003-06-30
4
J
0
5028
0
D
1997-01-30
2007-01-30
Genzyme Biosurgery common stock (GZBX)
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0
D
Biosurgery NQ stock option (right to buy)
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2003-06-30
4
J
0
4469
0
D
2006-07-30
2007-01-30
Genzyme Biosurgery common stock (GZBX)
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0
D
Biosurgery NQ stock option (right to buy)
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2003-06-30
4
J
0
3883
0
D
1997-10-16
2007-10-16
Genzyme Biosurgery common stock (GZBX)
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0
D
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2003-06-30
4
J
0
1829
0
D
1998-05-28
2008-05-28
Genzyme Biosurgery common stock (GZBX)
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0
D
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2003-06-30
4
J
0
9797
0
D
2001-01-25
2009-01-25
Genzyme Biosurgery common stock (GZBX)
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0
D
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2003-06-30
4
J
0
95445
0
D
1999-08-26
2009-08-26
Genzyme Biosurgery common stock (GZBX)
95445
0
D
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2003-06-30
4
J
0
100000
0
D
2001-07-17
2011-02-09
Genzyme Biosurgery common stock (GZBX)
100000
0
D
Biosurgery NQ stock option (right to buy)
6.26
2003-06-30
4
J
0
63000
0
D
2001-05-31
2011-05-31
Genzyme Biosurgery common stock (GZBX)
63000
0
D
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2003-06-30
4
J
0
75000
0
D
2002-05-30
2012-05-30
Genzyme Biosurgery common stock (GZBX)
75000
0
D
Genzyme General ISO stock option (right to buy)
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2003-06-30
4
J
0
248
0
A
1997-01-30
2007-01-30
Genzyme General common stock (GENZ)
248
248
D
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2003-06-30
4
J
0
3115
0
A
2001-05-31
2011-05-31
Genzyme General common stock (GENZ)
3115
3115
D
Genzyme General NQ stock option (right to buy)
656.02
2003-06-30
4
J
0
220
0
A
2006-07-30
2007-01-30
Genzyme General common stock (GENZ)
220
220
D
Genzyme General NQ stock option (right to buy)
595.76
2003-06-30
4
J
0
192
0
A
1997-10-16
2007-10-16
Genzyme General common stock (GENZ)
192
192
D
Genzyme General NQ stock option (right to buy)
124.69
2003-06-30
4
J
0
306
0
A
1998-05-28
2008-05-28
Genzyme General common stock (GENZ)
306
306
D
Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
90
0
A
1998-05-28
2008-05-28
Genzyme General common stock (GENZ)
90
90
D
Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
1640
0
A
2001-01-25
2009-01-25
Genzyme General common stock (GENZ)
1640
1640
D
Genzyme General NQ stock option (right to buy)
467.55
2003-06-30
4
J
0
484
0
A
2001-01-25
2009-01-25
Genzyme General common stock (GENZ)
484
484
D
Genzyme General NQ stock option (right to buy)
223.26
2003-06-30
4
J
0
4719
0
A
1999-08-26
2009-08-26
Genzyme General common stock (GENZ)
4719
4719
D
Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
479
0
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2000-05-25
2010-05-25
Genzyme General common stock (GENZ)
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479
D
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2003-06-30
4
J
0
4945
0
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2011-02-09
Genzyme General common stock (GENZ)
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4945
D
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2003-06-30
4
J
0
505
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2001-05-31
2011-05-31
Genzyme General common stock (GENZ)
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505
D
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2003-06-30
4
J
0
3708
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2002-05-30
2012-05-30
Genzyme General common stock (GENZ)
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3708
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2003-06-30
4
J
0
651
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2012-05-30
Genzyme General common stock (GENZ)
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D
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2003-06-30
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J
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A
1997-10-16
2007-10-16
Genzyme General common stock (GENZ)
421
421
D
Molecular Oncology NQ stock option (right to buy)
7.00
2003-06-30
4
J
0
7500
0
D
1997-10-16
2007-10-16
Genzyme Molecular Oncology common stock (GZMO)
7500
0
D
Molecular Oncology NQ stock option (right to buy)
7.00
2003-06-30
4
J
0
5459
0
D
1998-05-28
2008-05-28
Genzyme Molecular Oncology common stock (GZMO)
5459
0
D
Molecular Oncology NQ stock option (right to buy)
5.38
2003-06-30
4
J
0
29228
0
D
2001-01-25
2009-01-25
Genzyme Molecular Oncology common stock (GZMO)
29228
0
D
Molecular Oncology NQ stock option (right to buy)
12.73
2003-06-30
4
J
0
8542
0
D
2000-05-25
2010-05-25
Genzyme Molecular Oncology common stock (GZMO)
8542
0
D
Molecular Oncology NQ stock option (right to buy)
15.40
2003-06-30
4
J
0
9000
0
D
2001-05-31
2011-05-31
Genzyme Molecular Oncology common stock (GZMO)
9000
0
D
Molecular Oncology NQ stock option (right to buy)
2.33
2003-06-30
4
J
0
11600
0
D
2002-05-30
2012-05-30
Genzyme Molecular Oncology common stock (GZMO)
11600
0
D
On June 30, 2003 all outstanding shares of Genzyme Biosurgery and Genzyme Molecular stock were exchanged for shares of Genzyme General Stock.  Genzyme Biosurgery shareholders received .04914 of a share of Genzyme General stock for each Biosurgery share and Genzyme Molecular Oncology shareholders received .05653 of a share of Genzyme General stock for each Molecular Oncology share.
On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.
Options vest in 20% annual increments beginning on the original date of grant.
Options vest 20% on October 16, 1997 and in 20% annual increments beginning May 16, 1998.
Options were granted with an exercise price 100% above fair market value, and vest in 1/3 increments on each of Janary 25, 2001, 2002 and 2003.
Options vest 20% on August 26, 1999 and in 20% annual increments beginning May 26, 2000.
Options vest in 25% annual increments on July 17, 2001, 2002, 2003 and 2004.
Options vest 20% on 8/26/1999 and in 20% annual increments beginning May 26, 2000.
By: Susan P. Cogswell, Attorney-in-Fact
2003-07-01