<?xml version="1.0"?>
<!-- - EDGAR Ease Plus 1.0                                   04/22/03  TZ    -->
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType>
   <periodOfReport>2003-06-11</periodOfReport>
    <issuer>
        <issuerCik>0000725058</issuerCik>
        <issuerName>CYTOGEN CORP</issuerName>
        <issuerTradingSymbol>CYTO</issuerTradingSymbol>
   </issuer>
   <reportingOwner>
      <reportingOwnerId>
            <rptOwnerCik>0001022842</rptOwnerCik>
            <rptOwnerName>GRIGSBY JAMES A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
         <isDirector>1</isDirector>
         <isOfficer>0</isOfficer>
         <isTenPercentOwner>0</isTenPercentOwner>
         <isOther>0</isOther>
       </reportingOwnerRelationship>
   </reportingOwner>
   <derivativeSecurity>
      <securityTitle>
         <value>Common Stock Option (right to buy)</value>
      </securityTitle>
      <conversionOrExercisePrice>
         <value>5.84</value>
      </conversionOrExercisePrice>
      <transactionDate>
         <value>2003-06-11</value>
      </transactionDate>
      <transactionCoding>
         <transactionFormType>4</transactionFormType>
         <transactionCode>A</transactionCode>
         <equitySwapInvolved>0</equitySwapInvolved>
      </transactionCoding>
      <transactionAmounts>
         <transactionShares>
           <value>2500</value>
         </transactionShares>
         <transactionValue>
           <value>0</value>
         </transactionValue>
         <transactionAcquiredDisposedCode>
           <value>A</value>
         </transactionAcquiredDisposedCode>
      </transactionAmounts>
      <exerciseDate>
         <value>2004-06-11</value>
            <footnoteId id="F1"/>
      </exerciseDate>
      <expirationDate>
         <value>2013-06-11</value>
      </expirationDate>
      <underlyingSecurity>
         <underlyingSecurityTitle>
           <value>Common Stock</value>
         </underlyingSecurityTitle>
         <underlyingSecurityShares>
           <value>2500</value>
         </underlyingSecurityShares>
      </underlyingSecurity>
      <postTransactionAmounts>
         <sharesOwnedFollowingTransaction>
           <value>20600</value>
            <footnoteId id="F2"/>
         </sharesOwnedFollowingTransaction>
      </postTransactionAmounts>
      <ownershipNature>
         <directOrIndirectOwnership>
           <value>D</value>
         </directOrIndirectOwnership>
      </ownershipNature>
   </derivativeSecurity>
   <footnotes>
<footnote id="F1"> These options vest 100% after one year from the date of grant.</footnote>

<footnote id="F2"> Includes multiple option grants with different option prices and vesting dates. Such number has been adjusted to reflect the one for ten stock split that occured on October 28, 2002.</footnote>
   </footnotes>
   <ownerSignature>
      <signatureName>James Grigsby</signatureName>
      <signatureDate>2003-06-13</signatureDate>
   </ownerSignature>
</ownershipDocument>
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X0101
4
2003-06-11
0000725058
CYTOGEN CORP
CYTO
0001022842
GRIGSBY JAMES A
1
0
0
0
Common Stock Option (right to buy)
5.84
2003-06-11
4
A
0
2500
0
A
2004-06-11
2013-06-11
Common Stock
2500
20600
D
These options vest 100% after one year from the date of grant.
Includes multiple option grants with different option prices and vesting dates. Such number has been adjusted to reflect the one for ten stock split that occured on October 28, 2002.
James Grigsby
2003-06-13