<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType>
	<periodOfReport>2003-06-30</periodOfReport>
	<notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000732485</issuerCik>
        <issuerName>GENZYME CORP</issuerName>
        <issuerTradingSymbol>GENZ</issuerTradingSymbol>
	</issuer>
	<reportingOwner>
		<reportingOwnerId>
            <rptOwnerCik>0001021038</rptOwnerCik>
            <rptOwnerName>TERMEER HENRI A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
			<isDirector>1</isDirector>
			<isOfficer>1</isOfficer>
			<isTenPercentOwner>0</isTenPercentOwner>
			<isOther>0</isOther>
			<officerTitle>Chmn, President and CEO</officerTitle>
		</reportingOwnerRelationship>
	</reportingOwner>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Biosurgery common stock (GZBX)</value>
		</securityTitle>
		<transactionDate>
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		</transactionDate>
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			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
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			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
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	<nonDerivativeSecurity>
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		</postTransactionAmounts>
		<ownershipNature>
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			</directOrIndirectOwnership>
			<natureOfOwnership>
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			</natureOfOwnership>
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	<nonDerivativeSecurity>
		<securityTitle>
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		<transactionDate>
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		<ownershipNature>
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		</ownershipNature>
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	<nonDerivativeSecurity>
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		<transactionDate>
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		<ownershipNature>
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			<natureOfOwnership>
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		</ownershipNature>
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	<nonDerivativeSecurity>
		<securityTitle>
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		</securityTitle>
		<transactionDate>
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			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
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	<nonDerivativeSecurity>
		<securityTitle>
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		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
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			<natureOfOwnership>
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		</securityTitle>
		<transactionDate>
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		<securityTitle>
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		<securityTitle>
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		<transactionDate>
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	<nonDerivativeSecurity>
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		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
		</transactionCoding>
		<transactionAmounts>
			<transactionShares>
				<value>125000</value>
				<footnoteId id="F2"/>
			</transactionShares>
			<transactionValue>
				<value>0</value>
			</transactionValue>
			<transactionAcquiredDisposedCode>
				<value>D</value>
			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<exerciseDate>
			<value>2002-05-30</value>
			<footnoteId id="F5"/>
		</exerciseDate>
		<expirationDate>
			<value>2012-05-30</value>
		</expirationDate>
		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Molecular Oncology common stock (GZMO)</value>
			</underlyingSecurityTitle>
			<underlyingSecurityShares>
				<value>125000</value>
			</underlyingSecurityShares>
		</underlyingSecurity>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>0</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</derivativeSecurity>
	<footnotes>
		<footnote id="F1">On June 30, 2003 all outstanding shares of Genzyme Biosurgery and Genzyme Molecular stock were exchanged for shares of Genzyme General Stock.  Genzyme Biosurgery shareholders received .04914 of a share of Genzyme General stock for each Biosurgery share and Genzyme Molecular Oncology shareholders received .05653 of a share of Genzyme General stock for each Molecular Oncology share.</footnote>
		<footnote id="F2">On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.</footnote>
		<footnote id="F3">Options vest in 20% annual increments beginning 12/16/94.</footnote>
		<footnote id="F4">Options vest 20% on October 16, 1997 and in 20% annual increments beginning May 16, 1998.</footnote>
		<footnote id="F5">Options vest in 20% annual increments beginning on the original date of grant.</footnote>
		<footnote id="F6">Options were granted with an exercise price 100% above fair market value, and vest in 1/3 increments on each of Janary 25, 2001, 2002 and 2003.</footnote>
		<footnote id="F7">Options vest 20% on August 26, 1999 and in 20% annual increments beginning May 26, 2000.</footnote>
		<footnote id="F8">These options may be accelerated by the board if (1) in each of two consecutive calendar years the average annual Total Shareholder Return for the applicable Genzyme stock equals or exceeds the 75th percentile of the S&amp;P Biotechnology Index (super), and (2) the share price for the applicable Genzyme stock has appreciated at a rate equal to or greater than a compounded annual rate of ten percent from the date of grant.</footnote>
		<footnote id="F9">These options have a converted exercise price of $1,055.82 per share.</footnote>
	</footnotes>
	<ownerSignature>
		<signatureName>By: Susan P. Cogswell, Attorney-in-Fact</signatureName>
		<signatureDate>2003-07-02</signatureDate>
	</ownerSignature>
</ownershipDocument>
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X0101
4
2003-06-30
0
0000732485
GENZYME CORP
GENZ
0001021038
TERMEER HENRI A
1
1
0
0
Chmn, President and CEO
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
383265
0
D
0
D
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
1783
0
D
0
I
By 401(k)
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
2434
0
D
0
I
By Spouse
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
2899
0
D
0
I
By Trust
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
18833
0
A
584793
D
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
1262
0
A
586055
D
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
87
0
A
16424
I
By 401(k)
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
119
0
A
2365
I
By Spouse
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
6
0
A
2371
I
By Spouse
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
142
0
A
1142
I
By Trust
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
114
0
A
1256
I
By Trust
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
4
J
0
22332
0
D
0
D
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
4
J
0
8
0
D
0
I
By 401(k)
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
4
J
0
120
0
D
0
I
By Spouse
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
4
J
0
2019
0
D
0
I
By Trust
Biosurgery NQ stock option (right to buy)
14.17
2003-06-30
4
J
0
22123
0
D
1994-12-16
2004-12-16
Genzyme Biosurgery common stock (GZBX)
22123
0
D
Biosurgery NQ stock option (right to buy)
52.21
2003-06-30
4
J
0
18622
0
D
2005-06-30
2005-12-15
Genzyme Biosurgery common stock (GZBX)
18622
0
D
Biosurgery NQ stock option (right to buy)
29.46
2003-06-30
4
J
0
17430
0
D
1997-10-16
2007-10-16
Genzyme Biosurgery common stock (GZBX)
17430
0
D
Biosurgery NQ stock option (right to buy)
19.39
2003-06-30
4
J
0
10458
0
D
1998-05-28
2008-05-28
Genzyme Biosurgery common stock (GZBX)
10458
0
D
Biosurgery NQ stock option (right to buy)
23.12
2003-06-30
4
J
0
24770
0
D
2001-01-25
2009-01-25
Genzyme Biosurgery common stock (GZBX)
24770
0
D
Biosurgery NQ stock option (right to buy)
11.04
2003-06-30
4
J
0
95445
0
D
1999-08-26
2009-08-26
Genzyme Biosurgery common stock (GZBX)
95445
0
D
Biosurgery NQ stock option (right to buy)
6.26
2003-06-30
4
J
0
100000
0
D
2001-05-31
2011-05-31
Genzyme Biosurgery common stock (GZBX)
100000
0
D
Biosurgery NQ stock option (right to buy)
6.26
2003-06-30
4
J
0
150000
0
D
2008-05-31
2011-05-31
Genzyme Biosurgery common stock (GZBX)
150000
0
D
Biosurgery NQ stock option (right to buy)
4.24
2003-06-30
4
J
0
125000
0
D
2002-05-30
2012-05-30
Genzyme Biosurgery common stock (GZBX)
125000
0
D
Genzyme General NQ stock option (right to buy)
286.56
2003-06-30
4
J
0
1093
0
A
1994-12-16
2004-12-16
Genzyme General common stock (GENZ)
1093
1093
D
Genzyme General NQ stock option (right to buy)
0.00
2003-06-30
4
J
0
920
0
A
2005-06-30
2005-12-15
Genzyme General common stock (GENZ)
920
920
D
Genzyme General NQ stock option (right to buy)
595.76
2003-06-30
4
J
0
861
0
A
1997-10-16
2007-10-16
Genzyme General common stock (GENZ)
861
861
D
Genzyme General NQ stock option (right to buy)
124.69
2003-06-30
4
J
0
3705
0
A
1997-10-16
2007-10-16
Genzyme General common stock (GENZ)
3705
3705
D
Genzyme General NQ stock option (right to buy)
392.12
2003-06-30
4
J
0
517
0
A
1998-05-28
2008-05-28
Genzyme General common stock (GENZ)
517
517
D
Genzyme General NQ stock option (right to buy)
124.69
2003-06-30
4
J
0
1751
0
A
1998-05-28
2008-05-28
Genzyme General common stock (GENZ)
1751
1751
D
Genzyme General NQ stock option (right to buy)
467.55
2003-06-30
4
J
0
1224
0
A
2001-01-25
2009-01-25
Genzyme General common stock (GENZ)
1224
1224
D
Genzyme General NQ stock option (right to buy)
95.84
2003-06-30
4
J
0
4148
0
A
2001-01-25
2009-01-25
Genzyme General common stock (GENZ)
4148
4148
D
Genzyme General NQ stock option (right to buy)
223.26
2003-06-30
4
J
0
4719
0
A
1999-08-26
2009-08-26
Genzyme General common stock (GENZ)
4719
4719
D
Genzyme General NQ stock option (right to buy)
226.76
2003-06-30
4
J
0
8421
0
A
2000-05-25
2010-05-25
Genzyme General common stock (GENZ)
8421
8421
D
Genzyme General NQ stock option (right to buy)
126.60
2003-06-30
4
J
0
4945
0
A
2001-05-31
2011-05-31
Genzyme General common stock (GENZ)
4945
4945
D
Genzyme General NQ stock option (right to buy)
274.32
2003-06-30
4
J
0
5614
0
A
2001-05-31
2011-05-31
Genzyme General common stock (GENZ)
5614
5614
D
Genzyme General NQ stock option (right to buy)
126.60
2003-06-30
4
J
0
7417
0
A
2008-05-31
2011-05-31
Genzyme General common stock (GENZ)
7417
7417
D
Genzyme General NQ stock option (right to buy)
85.75
2003-06-30
4
J
0
6181
0
A
2002-05-30
2012-05-30
Genzyme General common stock (GENZ)
6181
6181
D
Genzyme General NQ stock option (right to buy)
41.51
2003-06-30
4
J
0
7017
0
A
2002-05-30
2012-05-30
Genzyme General common stock (GENZ)
7017
7017
D
Molecular Oncology NQ stock option (right to buy)
7.00
2003-06-30
4
J
0
66000
0
D
1997-10-16
2007-10-16
Genzyme Molecular Oncology common stock (GZMO)
66000
0
D
Molecular Oncology NQ stock option (right to buy)
7.00
2003-06-30
4
J
0
31200
0
D
1998-05-28
2008-05-28
Genzyme Molecular Oncology common stock (GZMO)
31200
0
D
Molecular Oncology NQ stock option (right to buy)
5.38
2003-06-30
4
J
0
73899
0
D
2001-01-25
2009-01-25
Genzyme Molecular Oncology common stock (GZMO)
73899
0
D
Molecular Oncology NQ stock option (right to buy)
12.73
2003-06-30
4
J
0
150000
0
D
2000-05-25
2010-05-25
Genzyme Molecular Oncology common stock (GZMO)
150000
0
D
Molecular Oncology NQ stock option (right to buy)
15.40
2003-06-30
4
J
0
100000
0
D
2001-05-31
2011-05-31
Genzyme Molecular Oncology common stock (GZMO)
100000
0
D
Molecular Oncology NQ stock option (right to buy)
2.33
2003-06-30
4
J
0
125000
0
D
2002-05-30
2012-05-30
Genzyme Molecular Oncology common stock (GZMO)
125000
0
D
On June 30, 2003 all outstanding shares of Genzyme Biosurgery and Genzyme Molecular stock were exchanged for shares of Genzyme General Stock.  Genzyme Biosurgery shareholders received .04914 of a share of Genzyme General stock for each Biosurgery share and Genzyme Molecular Oncology shareholders received .05653 of a share of Genzyme General stock for each Molecular Oncology share.
On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.
Options vest in 20% annual increments beginning 12/16/94.
Options vest 20% on October 16, 1997 and in 20% annual increments beginning May 16, 1998.
Options vest in 20% annual increments beginning on the original date of grant.
Options were granted with an exercise price 100% above fair market value, and vest in 1/3 increments on each of Janary 25, 2001, 2002 and 2003.
Options vest 20% on August 26, 1999 and in 20% annual increments beginning May 26, 2000.
These options may be accelerated by the board if (1) in each of two consecutive calendar years the average annual Total Shareholder Return for the applicable Genzyme stock equals or exceeds the 75th percentile of the S&P Biotechnology Index (super), and (2) the share price for the applicable Genzyme stock has appreciated at a rate equal to or greater than a compounded annual rate of ten percent from the date of grant.
These options have a converted exercise price of $1,055.82 per share.
By: Susan P. Cogswell, Attorney-in-Fact
2003-07-02