<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2024-11-19</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000109177</issuerCik>
        <issuerName>Spectrum Brands Holdings, Inc.</issuerName>
        <issuerTradingSymbol>SPB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001462723</rptOwnerCik>
            <rptOwnerName>Smeltser Jeremy W</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SPECTRUM BRANDS HOLDINGS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>3001 DEMING WAY</rptOwnerStreet2>
            <rptOwnerCity>MIDDLETON</rptOwnerCity>
            <rptOwnerState>WI</rptOwnerState>
            <rptOwnerZipCode>53562</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>EVP &amp; CFO</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2024-11-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>4986</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>90.26</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>62435</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Reporting Person was awarded restricted stock units which are settled in shares of common stock of the Issuer and which are scheduled to vest on December 3, 2027 if Reporting Person is an employee of the Issuer on such date.</footnote>
    </footnotes>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Laurel McKellips, Attorney-in-fact for Jeremy Smeltser</signatureName>
        <signatureDate>2024-11-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
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X0508
4
2024-11-19
0
0000109177
Spectrum Brands Holdings, Inc.
SPB
0001462723
Smeltser Jeremy W
C/O SPECTRUM BRANDS HOLDINGS, INC.
3001 DEMING WAY
MIDDLETON
WI
53562
0
1
0
0
EVP & CFO
0
Common Stock
2024-11-19
4
A
0
4986
90.26
A
62435
D
Reporting Person was awarded restricted stock units which are settled in shares of common stock of the Issuer and which are scheduled to vest on December 3, 2027 if Reporting Person is an employee of the Issuer on such date.
Exhibit 24 - Power of Attorney
/s/ Laurel McKellips, Attorney-in-fact for Jeremy Smeltser
2024-11-20