<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2007-01-08</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000097745</issuerCik>
        <issuerName>THERMO FISHER SCIENTIFIC INC.</issuerName>
        <issuerTradingSymbol>TMO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001216070</rptOwnerCik>
            <rptOwnerName>HOOGASIAN SETH H</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>81 WYMAN STREET</rptOwnerStreet1>
            <rptOwnerStreet2>P.O. BOX 9046</rptOwnerStreet2>
            <rptOwnerCity>WALTHAM</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>024549046</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Sr. VP, Gen. Counsel &amp; Sec.</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-01-08</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>957</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>11.89</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>39239.00</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-01-08</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
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            </transactionCoding>
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                </transactionShares>
                <transactionPricePerShare>
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                </transactionPricePerShare>
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                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
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                </natureOfOwnership>
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        </nonDerivativeTransaction>
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            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
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                <transactionShares>
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                </transactionShares>
                <transactionPricePerShare>
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                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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                </transactionAcquiredDisposedCode>
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                </natureOfOwnership>
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                </transactionShares>
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            </postTransactionAmounts>
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                </natureOfOwnership>
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                </natureOfOwnership>
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        </nonDerivativeTransaction>
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            </transactionDate>
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            <transactionAmounts>
                <transactionShares>
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                </transactionShares>
                <transactionPricePerShare>
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                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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            </transactionAmounts>
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                </sharesOwnedFollowingTransaction>
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            <ownershipNature>
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                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-01-08</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
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                <transactionShares>
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                </transactionShares>
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                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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                </transactionAcquiredDisposedCode>
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            <postTransactionAmounts>
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                    <value>77897.00</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
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                <natureOfOwnership>
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                </natureOfOwnership>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
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            <transactionDate>
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            </transactionDate>
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                </transactionShares>
                <transactionPricePerShare>
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                <transactionAcquiredDisposedCode>
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                <transactionShares>
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        <derivativeTransaction>
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                <transactionShares>
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        <derivativeTransaction>
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            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>261.00</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 13, 2006.</footnote>
        <footnote id="F2">Immediately</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>By: Barbara J. Lucas, Attorney-in-Fact for Seth H. Hoogasian</signatureName>
        <signatureDate>2007-01-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
[{"type": "4", "sequence": "1", "filename": "hoo467.xml", "secsgml_size_bytes": 65944}]
X0202
4
2007-01-08
0
0000097745
THERMO FISHER SCIENTIFIC INC.
TMO
0001216070
HOOGASIAN SETH H
81 WYMAN STREET
P.O. BOX 9046
WALTHAM
MA
024549046
0
1
0
0
Sr. VP, Gen. Counsel & Sec.
Common Stock
2007-01-08
4
M
0
957
11.89
A
39239.00
D
Common Stock
2007-01-08
4
M
0
858
10.86
A
40097.00
D
Common Stock
2007-01-08
4
M
0
1751
15.55
A
41848.00
D
Common Stock
2007-01-08
4
M
0
1018
14.28
A
42866.00
D
Common Stock
2007-01-08
4
M
0
436
10.71
A
43302.00
D
Common Stock
2007-01-08
4
M
0
25000
22.47
A
68302.00
D
Common Stock
2007-01-08
4
M
0
9595
22.47
A
77897.00
D
Common Stock
2007-01-08
4
M
0
261
12.23
A
78158.00
D
Common Stock
2007-01-08
4
M
0
10000
20.27
A
88158.00
D
Common Stock
2007-01-08
4
M
0
315
11.10
A
88473.00
D
Common Stock
2007-01-08
4
M
0
721
26.59
A
89194.00
D
Common Stock
2007-01-08
4
M
0
432
27.78
A
89626.00
D
Common Stock
2007-01-08
4
S
0
100
44.86
D
89526.00
D
Common Stock
2007-01-08
4
S
0
100
44.87
D
89426.00
D
Common Stock
2007-01-08
4
S
0
300
44.88
D
89126.00
D
Common Stock
2007-01-08
4
S
0
1600
44.89
D
87526.00
D
Common Stock
2007-01-08
4
S
0
3100
44.90
D
84426.00
D
Common Stock
2007-01-08
4
S
0
12700
44.91
D
71726.00
D
Common Stock
2007-01-08
4
S
0
600
44.92
D
71126.00
D
Common Stock
2007-01-08
4
S
0
920
44.93
D
70206.00
D
Common Stock
2007-01-08
4
S
0
5100
44.94
D
65106.00
D
Common Stock
2007-01-08
4
S
0
300
44.95
D
64806.00
D
Common Stock
2007-01-08
4
S
0
5200
44.97
D
59606.00
D
Common Stock
2007-01-08
4
S
0
21324
45.00
D
38282.00
D
Common Stock
411.00
I
By 401(k)
Stock Option (Right to Buy)
11.89
2007-01-08
4
M
0
957
0
D
1996-01-10
2008-01-10
Common Stock
957.00
0.00
D
Stock Option (Right to Buy)
15.55
2007-01-08
4
M
0
1751
0
D
1996-03-01
2008-03-01
Common Stock
1751.00
0.00
D
Stock Option (Right to Buy)
22.47
2007-01-08
4
M
0
25000
0
D
2008-03-14
Common Stock
25000.00
19191.00
D
Stock Option (Right to Buy)
22.47
2007-01-08
4
M
0
9595
0
D
2008-03-14
Common Stock
9595.00
9596.00
D
Stock Option (Right to Buy)
10.86
2007-01-08
4
M
0
858
0
D
1996-04-11
2008-04-11
Common Stock
858.00
0.00
D
Stock Option (Right to Buy)
14.28
2007-01-08
4
M
0
1018
0
D
1996-08-14
2008-08-14
Common Stock
1018.00
0.00
D
Stock Option (Right to Buy)
10.71
2007-01-08
4
M
0
436
0
D
1998-12-21
2008-12-21
Common Stock
436.00
0.00
D
Stock Option (Right to Buy)
20.27
2007-01-08
4
M
0
10000
0
D
2009-03-15
Common Stock
10000.00
32500.00
D
Stock Option (Right to Buy)
26.59
2007-01-08
4
M
0
721
0
D
1997-05-23
2009-05-23
Common Stock
721.00
722.00
D
Stock Option (Right to Buy)
27.78
2007-01-08
4
M
0
432
0
D
1997-05-23
2009-05-23
Common Stock
432.00
432.00
D
Stock Option (Right to Buy)
11.10
2007-01-08
4
M
0
315
0
D
1997-06-10
2009-06-10
Common Stock
315.00
316.00
D
Stock Option (Right to Buy)
12.23
2007-01-08
4
M
0
261
0
D
1997-10-01
2009-10-01
Common Stock
261.00
261.00
D
The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 13, 2006.
Immediately
By: Barbara J. Lucas, Attorney-in-Fact for Seth H. Hoogasian
2007-01-09