<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType>
	<periodOfReport>2003-06-30</periodOfReport>
	<notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000732485</issuerCik>
        <issuerName>GENZYME CORP</issuerName>
        <issuerTradingSymbol>GENZ</issuerTradingSymbol>
	</issuer>
	<reportingOwner>
		<reportingOwnerId>
            <rptOwnerCik>0001021029</rptOwnerCik>
            <rptOwnerName>MOSCICKI RICHARD A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
			<isDirector>0</isDirector>
			<isOfficer>1</isOfficer>
			<isTenPercentOwner>0</isTenPercentOwner>
			<isOther>0</isOther>
			<officerTitle>Senior Vice President</officerTitle>
		</reportingOwnerRelationship>
	</reportingOwner>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Biosurgery common stock (GZBX)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
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			<equitySwapInvolved>0</equitySwapInvolved>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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			</transactionAcquiredDisposedCode>
		</transactionAmounts>
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				<value>0</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
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			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
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		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
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		<transactionAmounts>
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			<transactionValue>
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		<postTransactionAmounts>
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				<value>0</value>
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		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value>By 401(k)</value>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
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			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
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		<transactionAmounts>
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			</transactionShares>
			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
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			</sharesOwnedFollowingTransaction>
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		<ownershipNature>
			<directOrIndirectOwnership>
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			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
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	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>5827</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
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			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Molecular Oncology common stock (GZMO)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
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				<value>0</value>
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		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
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			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Molecular Oncology common stock (GZMO)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
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			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value>By 401(k)</value>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery ISO stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>17.90</value>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
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		<transactionAmounts>
			<transactionShares>
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				<footnoteId id="F2"/>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		</transactionAmounts>
		<exerciseDate>
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			<footnoteId id="F3"/>
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		<expirationDate>
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		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Biosurgery common stock (GZBX)</value>
			</underlyingSecurityTitle>
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		<postTransactionAmounts>
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		<ownershipNature>
			<directOrIndirectOwnership>
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			<natureOfOwnership>
				<value/>
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	<derivativeSecurity>
		<securityTitle>
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		<transactionDate>
			<value>2003-06-30</value>
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				<footnoteId id="F2"/>
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			<transactionValue>
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		<exerciseDate>
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		<expirationDate>
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		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Biosurgery common stock (GZBX)</value>
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		<postTransactionAmounts>
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		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
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			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</derivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>15.12</value>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
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		<transactionAmounts>
			<transactionShares>
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		<exerciseDate>
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		<expirationDate>
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		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Biosurgery common stock (GZBX)</value>
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		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
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			<natureOfOwnership>
				<value/>
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	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
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			<value>15.30</value>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
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		<transactionCoding>
			<transactionFormType>4</transactionFormType>
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		<transactionAmounts>
			<transactionShares>
				<value>384</value>
				<footnoteId id="F2"/>
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				<value>0</value>
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		<exerciseDate>
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		<underlyingSecurity>
			<underlyingSecurityTitle>
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		<postTransactionAmounts>
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		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
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			<natureOfOwnership>
				<value/>
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	</derivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>14.10</value>
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		<transactionDate>
			<value>2003-06-30</value>
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		<transactionCoding>
			<transactionFormType>4</transactionFormType>
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		<transactionAmounts>
			<transactionShares>
				<value>452</value>
				<footnoteId id="F2"/>
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			<transactionValue>
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		<exerciseDate>
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			<footnoteId id="F5"/>
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			<underlyingSecurityTitle>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
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		<ownershipNature>
			<directOrIndirectOwnership>
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			<natureOfOwnership>
				<value/>
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	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
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			<value>14.17</value>
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		<transactionDate>
			<value>2003-06-30</value>
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		<transactionCoding>
			<transactionFormType>4</transactionFormType>
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		<transactionAmounts>
			<transactionShares>
				<value>5028</value>
				<footnoteId id="F2"/>
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			<transactionValue>
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			<directOrIndirectOwnership>
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			<natureOfOwnership>
				<value/>
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	<derivativeSecurity>
		<securityTitle>
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				<value/>
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	<derivativeSecurity>
		<securityTitle>
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			<value>2003-06-30</value>
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				<value/>
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			<footnoteId id="F9"/>
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		<footnote id="F1">On June 30, 2003 all outstanding shares of Genzyme Biosurgery and Genzyme Molecular stock were exchanged for shares of Genzyme General Stock.  Genzyme Biosurgery shareholders received .04914 of a share of Genzyme General stock for each Biosurgery share and Genzyme Molecular Oncology shareholders received .05653 of a share of Genzyme General stock for each Molecular Oncology share.</footnote>
		<footnote id="F2">On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.</footnote>
		<footnote id="F3">Options vest in 20% annual increments beginning 5/18/95.</footnote>
		<footnote id="F4">Options vest in 20% annual increments beginning 5/16/96.</footnote>
		<footnote id="F5">Options vest in 1/3 increments on December 8, 1994, March 14, 1996 and March 4, 1997</footnote>
		<footnote id="F6">Options vest in 20% annual increments beginning 12/16/94.</footnote>
		<footnote id="F7">Options were granted with an exercise price 100% above fair market value, and vest in 1/3 increments on each of Janary 25, 2001, 2002 and 2003.</footnote>
		<footnote id="F8">Options vest 20% on August 26, 1999 and in 20% annual increments beginning May 26, 2000.</footnote>
		<footnote id="F9">Options vest in 25% annual increments on July 17, 2001, 2002, 2003 and 2004.</footnote>
		<footnote id="F10">Options vest in 20% annual increments beginning on the original date of grant.</footnote>
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	<ownerSignature>
		<signatureName>By: Susan P. Cogswell, Attorney-in-Fact</signatureName>
		<signatureDate>2003-07-02</signatureDate>
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X0101
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2003-06-30
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0000732485
GENZYME CORP
GENZ
0001021029
MOSCICKI RICHARD A
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1
0
0
Senior Vice President
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
4705
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D
0
D
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
2
0
D
0
I
By 401(k)
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2003-06-30
4
J
0
231
0
A
5816
D
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
11
0
A
5827
D
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
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J
0
207
0
D
0
D
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
4
J
0
5
0
D
0
I
By 401(k)
Biosurgery ISO stock option (right to buy)
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2003-06-30
4
J
0
1709
0
D
1995-05-18
2005-05-18
Genzyme Biosurgery common stock (GZBX)
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0
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Biosurgery ISO stock option (right to buy)
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2003-06-30
4
J
0
1709
0
D
1996-05-16
2006-05-16
Genzyme Biosurgery common stock (GZBX)
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0
D
Biosurgery NQ stock option (right to buy)
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2003-06-30
4
J
0
1131
0
D
2003-06-30
2003-12-08
Genzyme Biosurgery common stock (GZBX)
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0
D
Biosurgery NQ stock option (right to buy)
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2003-06-30
4
J
0
384
0
D
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2004-05-19
Genzyme Biosurgery common stock (GZBX)
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0
D
Biosurgery NQ stock option (right to buy)
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2003-06-30
4
J
0
452
0
D
1994-12-08
2004-12-08
Genzyme Biosurgery common stock (GZBX)
452
0
D
Biosurgery NQ stock option (right to buy)
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2003-06-30
4
J
0
5028
0
D
1994-12-16
2004-12-16
Genzyme Biosurgery common stock (GZBX)
5028
0
D
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2003-06-30
4
J
0
8052
0
D
2001-01-25
2009-01-25
Genzyme Biosurgery common stock (GZBX)
8052
0
D
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11.04
2003-06-30
4
J
0
11817
0
D
1999-08-26
2009-08-26
Genzyme Biosurgery common stock (GZBX)
11817
0
D
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6.69
2003-06-30
4
J
0
10392
0
D
2001-07-17
2011-02-09
Genzyme Biosurgery common stock (GZBX)
10392
0
D
Biosurgery NQ stock option (right to buy)
6.26
2003-06-30
4
J
0
14000
0
D
2001-05-31
2011-05-31
Genzyme Biosurgery common stock (GZBX)
14000
0
D
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2003-06-30
4
J
0
16300
0
D
2002-05-30
2012-05-30
Genzyme Biosurgery common stock (GZBX)
16300
0
D
Genzyme General ISO stock option (right to buy)
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2003-06-30
4
J
0
84
0
A
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2005-05-18
Genzyme General common stock (GENZ)
84
84
D
Genzyme General ISO stock option (right to buy)
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2003-06-30
4
J
0
84
0
A
1996-06-16
2006-05-16
Genzyme General common stock (GENZ)
84
84
D
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2003-06-30
4
J
0
55
0
A
2003-06-30
2003-12-08
Genzyme General common stock (GENZ)
55
55
D
Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
18
0
A
1994-05-19
2004-05-19
Genzyme General common stock (GENZ)
18
18
D
Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
22
0
A
1994-12-08
2004-12-08
Genzyme General common stock (GENZ)
22
22
D
Genzyme General NQ stock option (right to buy)
286.56
2003-06-30
4
J
0
248
0
A
1994-12-16
2004-12-16
Genzyme General common stock (GENZ)
248
248
D
Genzyme General NQ stock option (right to buy)
467.55
2003-06-30
4
J
0
398
0
A
2001-01-25
2009-01-25
Genzyme General common stock (GENZ)
398
398
D
Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
1348
0
A
2001-01-25
2009-01-25
Genzyme General common stock (GENZ)
1348
1348
D
Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
584
0
A
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2009-08-26
Genzyme General common stock (GENZ)
584
584
D
Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
596
0
A
2000-05-25
2010-05-25
Genzyme General common stock (GENZ)
596
596
D
Genzyme General NQ stock option (right to buy)
135.29
2003-06-30
4
J
0
513
0
A
2001-07-17
2011-02-09
Genzyme General common stock (GENZ)
513
513
D
Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
692
0
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2001-05-31
2011-05-31
Genzyme General common stock (GENZ)
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692
D
Genzyme General NQ stock option (right to buy)
274.32
2003-06-30
4
J
0
785
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A
2001-05-31
2011-05-31
Genzyme General common stock (GENZ)
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785
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Genzyme General NQ stock option (right to buy)
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2003-06-30
4
J
0
806
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2012-05-30
Genzyme General common stock (GENZ)
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806
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2003-06-30
4
J
0
830
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2012-05-30
Genzyme General common stock (GENZ)
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830
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2003-06-30
4
J
0
24023
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2001-01-25
2009-01-25
Genzyme Molecular Oncology common stock (GZMO)
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2003-06-30
4
J
0
10631
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2010-05-25
Genzyme Molecular Oncology common stock (GZMO)
10631
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2003-06-30
4
J
0
14000
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2011-05-31
Genzyme Molecular Oncology common stock (GZMO)
14000
0
D
Molecular Oncology NQ stock option (right to buy)
2.33
2003-06-30
4
J
0
14800
0
D
2002-05-30
2012-05-30
Genzyme Molecular Oncology common stock (GZMO)
14800
0
D
On June 30, 2003 all outstanding shares of Genzyme Biosurgery and Genzyme Molecular stock were exchanged for shares of Genzyme General Stock.  Genzyme Biosurgery shareholders received .04914 of a share of Genzyme General stock for each Biosurgery share and Genzyme Molecular Oncology shareholders received .05653 of a share of Genzyme General stock for each Molecular Oncology share.
On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.
Options vest in 20% annual increments beginning 5/18/95.
Options vest in 20% annual increments beginning 5/16/96.
Options vest in 1/3 increments on December 8, 1994, March 14, 1996 and March 4, 1997
Options vest in 20% annual increments beginning 12/16/94.
Options were granted with an exercise price 100% above fair market value, and vest in 1/3 increments on each of Janary 25, 2001, 2002 and 2003.
Options vest 20% on August 26, 1999 and in 20% annual increments beginning May 26, 2000.
Options vest in 25% annual increments on July 17, 2001, 2002, 2003 and 2004.
Options vest in 20% annual increments beginning on the original date of grant.
By: Susan P. Cogswell, Attorney-in-Fact
2003-07-02