<?xml version="1.0"?>
<!-- - EDGAR Ease Plus 1.0                                   07/25/03  TT    -->
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType>
   <periodOfReport>2003-09-04</periodOfReport>
   <notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000725058</issuerCik>
        <issuerName>CYTOGEN CORP</issuerName>
        <issuerTradingSymbol>CYTO</issuerTradingSymbol>
   </issuer>
   <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001127785</rptOwnerCik>
            <rptOwnerName>SCHNITTKER CHRISTOPHER P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CYTOGEN CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>650 COLLEGE ROAD EAST CN-5308</rptOwnerStreet2>
            <rptOwnerCity>PRINCETON</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08540</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
         <isDirector>0</isDirector>
         <isOfficer>1</isOfficer>
         <isTenPercentOwner>0</isTenPercentOwner>
         <isOther>0</isOther>
         <officerTitle>VP and Chief Financial Officer</officerTitle>
      </reportingOwnerRelationship>
   </reportingOwner>
 <derivativeTable>
   <derivativeTransaction>
      <securityTitle>
         <value>Options to Purchase Common Stock</value>
      </securityTitle>
      <conversionOrExercisePrice>
         <value>9.30</value>
      </conversionOrExercisePrice>
      <transactionDate>
         <value>2003-09-04</value>
      </transactionDate>
      <transactionCoding>
         <transactionFormType>4</transactionFormType>
         <transactionCode>A</transactionCode>
         <equitySwapInvolved>0</equitySwapInvolved>
      </transactionCoding>
      <transactionAmounts>
         <transactionShares>
           <value>20000</value>
         </transactionShares>
         <transactionPricePerShare>
           <value>0</value>
         </transactionPricePerShare>
         <transactionAcquiredDisposedCode>
           <value>A</value>
         </transactionAcquiredDisposedCode>
      </transactionAmounts>
      <exerciseDate>
         <value>2004-09-04</value>
            <footnoteId id="F1"/>
      </exerciseDate>
      <expirationDate>
         <value>2013-09-04</value>
      </expirationDate>
      <underlyingSecurity>
         <underlyingSecurityTitle>
           <value>Common Stock, par value $0.01 per share</value>
         </underlyingSecurityTitle>
         <underlyingSecurityShares>
           <value>20000</value>
         </underlyingSecurityShares>
      </underlyingSecurity>
      <postTransactionAmounts>
         <sharesOwnedFollowingTransaction>
           <value>20000</value>
         </sharesOwnedFollowingTransaction>
      </postTransactionAmounts>
      <ownershipNature>
         <directOrIndirectOwnership>
           <value>D</value>
         </directOrIndirectOwnership>
      </ownershipNature>
   </derivativeTransaction>
 </derivativeTable>
   <footnotes>
      <footnote id="F1"> Mr. Schnittker did not hold any derivative or non-derivative securities of the company prior to his commencement of employment on 09/04/2003. Such options were granted to Mr. Schnittker upon his commencement of employment, and vest, subject to certain criteria, as follows: (i) 6,667 on 09/04/2004; (ii) 6,666 on 09/04/2005; and (iii) 6,667 on 09/04/2006.</footnote>
   </footnotes>
   <ownerSignature>
      <signatureName>Donald L. Novajosky, as Power of Attorney</signatureName>
      <signatureDate>2003-09-08</signatureDate>
   </ownerSignature>
</ownershipDocument>
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X0201
4
2003-09-04
0
0000725058
CYTOGEN CORP
CYTO
0001127785
SCHNITTKER CHRISTOPHER P
C/O CYTOGEN CORPORATION
650 COLLEGE ROAD EAST CN-5308
PRINCETON
NJ
08540
0
1
0
0
VP and Chief Financial Officer
Options to Purchase Common Stock
9.30
2003-09-04
4
A
0
20000
0
A
2004-09-04
2013-09-04
Common Stock, par value $0.01 per share
20000
20000
D
Mr. Schnittker did not hold any derivative or non-derivative securities of the company prior to his commencement of employment on 09/04/2003. Such options were granted to Mr. Schnittker upon his commencement of employment, and vest, subject to certain criteria, as follows: (i) 6,667 on 09/04/2004; (ii) 6,666 on 09/04/2005; and (iii) 6,667 on 09/04/2006.
Donald L. Novajosky, as Power of Attorney
2003-09-08