<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2004-06-15</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000725058</issuerCik>
        <issuerName>CYTOGEN CORP</issuerName>
        <issuerTradingSymbol>CYTO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001211250</rptOwnerCik>
            <rptOwnerName>GOECKELER WILLIAM F</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CYTOGEN CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>650 COLLEGE ROAD EAST CN-5308, STE 3100</rptOwnerStreet2>
            <rptOwnerCity>PRINCETON</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08540-5308</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Sr. Vice President Operations</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Options to Purchase Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>11.50</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2004-06-15</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>30000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2005-06-15</value>
            </exerciseDate>
            <expirationDate>
                <value>2014-06-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>30000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>30000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Such options were granted pursuant to the terms of the Company's 2004 Stock Incentive Plan and vest in three equal annual
installments beginning on the first anniversary of the date of grant.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Donald L. Novajosky, Esq., by power of attorney</signatureName>
        <signatureDate>2004-06-16</signatureDate>
    </ownerSignature>
</ownershipDocument>
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X0202
4
2004-06-15
0
0000725058
CYTOGEN CORP
CYTO
0001211250
GOECKELER WILLIAM F
C/O CYTOGEN CORPORATION
650 COLLEGE ROAD EAST CN-5308, STE 3100
PRINCETON
NJ
08540-5308
0
1
0
0
Sr. Vice President Operations
Options to Purchase Common Stock
11.50
2004-06-15
4
A
0
30000
0
A
2005-06-15
2014-06-15
Common Stock
30000
30000
D
Such options were granted pursuant to the terms of the Company's 2004 Stock Incentive Plan and vest in three equal annual
installments beginning on the first anniversary of the date of grant.
/s/ Donald L. Novajosky, Esq., by power of attorney
2004-06-16