<?xml version="1.0"?>
<!-- - EDGAR Ease Plus 1.0                                   04/22/03  TZ    -->
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType>
   <periodOfReport>2003-06-11</periodOfReport>
    <issuer>
        <issuerCik>0000725058</issuerCik>
        <issuerName>CYTOGEN CORP</issuerName>
        <issuerTradingSymbol>CYTO</issuerTradingSymbol>
   </issuer>
   <reportingOwner>
      <reportingOwnerId>
            <rptOwnerCik>0001211256</rptOwnerCik>
            <rptOwnerName>LOKAY KEVIN G</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
         <isDirector>1</isDirector>
         <isOfficer>0</isOfficer>
         <isTenPercentOwner>0</isTenPercentOwner>
         <isOther>0</isOther>
       </reportingOwnerRelationship>
   </reportingOwner>
   <derivativeSecurity>
      <securityTitle>
         <value>Common Stock Option (right to buy)</value>
      </securityTitle>
      <conversionOrExercisePrice>
         <value>5.84</value>
      </conversionOrExercisePrice>
      <transactionDate>
         <value>2003-06-11</value>
      </transactionDate>
      <transactionCoding>
         <transactionFormType>4</transactionFormType>
         <transactionCode>A</transactionCode>
         <equitySwapInvolved>0</equitySwapInvolved>
      </transactionCoding>
      <transactionAmounts>
         <transactionShares>
           <value>1000</value>
         </transactionShares>
         <transactionValue>
           <value>0</value>
         </transactionValue>
         <transactionAcquiredDisposedCode>
           <value>A</value>
         </transactionAcquiredDisposedCode>
      </transactionAmounts>
      <exerciseDate>
         <value>2004-06-11</value>
            <footnoteId id="F1"/>
      </exerciseDate>
      <expirationDate>
         <value>2013-06-11</value>
      </expirationDate>
      <underlyingSecurity>
         <underlyingSecurityTitle>
           <value>Common Stock</value>
         </underlyingSecurityTitle>
         <underlyingSecurityShares>
           <value>1000</value>
         </underlyingSecurityShares>
      </underlyingSecurity>
      <postTransactionAmounts>
         <sharesOwnedFollowingTransaction>
           <value>4333</value>
            <footnoteId id="F2"/>
         </sharesOwnedFollowingTransaction>
      </postTransactionAmounts>
      <ownershipNature>
         <directOrIndirectOwnership>
           <value>D</value>
         </directOrIndirectOwnership>
      </ownershipNature>
   </derivativeSecurity>
   <footnotes>
<footnote id="F1"> These options vest 100% after one year from the date of grant.</footnote>

<footnote id="F2"> Includes multiple option grants with different option prices and vesting dates.  Such number has been adjusted to reflect the one for ten stock split that occured on October 28, 2002.</footnote>
   </footnotes>
   <ownerSignature>
      <signatureName>Kevin G. Lokay</signatureName>
      <signatureDate>2003-06-13</signatureDate>
   </ownerSignature>
</ownershipDocument>
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X0101
4
2003-06-11
0000725058
CYTOGEN CORP
CYTO
0001211256
LOKAY KEVIN G
1
0
0
0
Common Stock Option (right to buy)
5.84
2003-06-11
4
A
0
1000
0
A
2004-06-11
2013-06-11
Common Stock
1000
4333
D
These options vest 100% after one year from the date of grant.
Includes multiple option grants with different option prices and vesting dates.  Such number has been adjusted to reflect the one for ten stock split that occured on October 28, 2002.
Kevin G. Lokay
2003-06-13