<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType>
	<periodOfReport>2003-06-30</periodOfReport>
	<notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000732485</issuerCik>
        <issuerName>GENZYME CORP</issuerName>
        <issuerTradingSymbol>GENZ</issuerTradingSymbol>
	</issuer>
	<reportingOwner>
		<reportingOwnerId>
            <rptOwnerCik>0001021040</rptOwnerCik>
            <rptOwnerName>VAN HEEK G JAN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
			<isDirector>0</isDirector>
			<isOfficer>1</isOfficer>
			<isTenPercentOwner>0</isTenPercentOwner>
			<isOther>0</isOther>
			<officerTitle>Executive Vice President</officerTitle>
		</reportingOwnerRelationship>
	</reportingOwner>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Biosurgery common stock (GZBX)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
		</transactionCoding>
		<transactionAmounts>
			<transactionShares>
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			</transactionShares>
			<transactionValue>
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			</transactionValue>
			<transactionAcquiredDisposedCode>
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			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>0</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
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			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Biosurgery common stock (GZBX)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
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		<transactionAmounts>
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			</transactionShares>
			<transactionValue>
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			</transactionValue>
			<transactionAcquiredDisposedCode>
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			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<postTransactionAmounts>
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			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value>By 401(k)</value>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Biosurgery common stock (GZBX)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
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			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			</transactionShares>
			<transactionValue>
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			</transactionValue>
			<transactionAcquiredDisposedCode>
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			</transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
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			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
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			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Biosurgery common stock (GZBX)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
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			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			</transactionShares>
			<transactionValue>
				<value>0</value>
			</transactionValue>
			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
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			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value>By Spouse</value>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
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			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>2578</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			</transactionShares>
			<transactionValue>
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			<transactionAcquiredDisposedCode>
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			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>2701</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
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			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
		</securityTitle>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<deemedExecutionDate>
			<value>2003-06-30</value>
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		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>M</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
		</transactionCoding>
		<transactionAmounts>
			<transactionShares>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
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		<ownershipNature>
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			<natureOfOwnership>
				<value/>
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	<nonDerivativeSecurity>
		<securityTitle>
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		<transactionDate>
			<value>2003-06-30</value>
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		<deemedExecutionDate>
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			<transactionCode>S</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
			<footnoteId id="F2"/>
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		<transactionAmounts>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
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		<ownershipNature>
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			<natureOfOwnership>
				<value/>
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	<nonDerivativeSecurity>
		<securityTitle>
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		<transactionDate>
			<value>2003-06-30</value>
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			<footnoteId id="F1"/>
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			<transactionShares>
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			<transactionValue>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>806</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
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			<natureOfOwnership>
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			</natureOfOwnership>
		</ownershipNature>
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	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
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		<transactionDate>
			<value>2003-06-30</value>
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			<transactionShares>
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			<transactionValue>
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		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
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			</natureOfOwnership>
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	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme General common stock (GENZ)</value>
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		<transactionDate>
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			<transactionShares>
				<value>27</value>
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			<sharesOwnedFollowingTransaction>
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		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
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			<natureOfOwnership>
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	<nonDerivativeSecurity>
		<securityTitle>
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		<transactionDate>
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		<transactionAmounts>
			<transactionShares>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>3534</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
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			<natureOfOwnership>
				<value>By Spouse</value>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Molecular Oncology common stock (GZMO)</value>
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		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
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			<transactionFormType>4</transactionFormType>
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			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
				<value>2181</value>
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			<transactionValue>
				<value>0</value>
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			<transactionAcquiredDisposedCode>
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		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>0</value>
			</sharesOwnedFollowingTransaction>
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		<ownershipNature>
			<directOrIndirectOwnership>
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			<natureOfOwnership>
				<value/>
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	<nonDerivativeSecurity>
		<securityTitle>
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		<transactionDate>
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			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			<transactionAcquiredDisposedCode>
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		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
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		</ownershipNature>
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	<nonDerivativeSecurity>
		<securityTitle>
			<value>Genzyme Molecular Oncology common stock (GZMO)</value>
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		<transactionDate>
			<value>2003-06-30</value>
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			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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	<nonDerivativeSecurity>
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		<transactionDate>
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			<footnoteId id="F1"/>
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		<transactionAmounts>
			<transactionShares>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<ownershipNature>
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			<natureOfOwnership>
				<value>By Spouse</value>
			</natureOfOwnership>
		</ownershipNature>
	</nonDerivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
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		<conversionOrExercisePrice>
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		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
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			<transactionCode>J</transactionCode>
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		<transactionAmounts>
			<transactionShares>
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				<footnoteId id="F3"/>
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			<transactionAcquiredDisposedCode>
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			<value>2003-06-30</value>
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		<expirationDate>
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		<postTransactionAmounts>
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		<ownershipNature>
			<directOrIndirectOwnership>
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			<natureOfOwnership>
				<value/>
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				<footnoteId id="F3"/>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<exerciseDate>
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			<footnoteId id="F4"/>
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		<expirationDate>
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		<underlyingSecurity>
			<underlyingSecurityTitle>
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				<value>0</value>
			</transactionValue>
			<transactionAcquiredDisposedCode>
				<value>D</value>
			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<exerciseDate>
			<value>2000-05-25</value>
		</exerciseDate>
		<expirationDate>
			<value>2010-05-25</value>
		</expirationDate>
		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Molecular Oncology common stock (GZMO)</value>
			</underlyingSecurityTitle>
			<underlyingSecurityShares>
				<value>4063</value>
			</underlyingSecurityShares>
		</underlyingSecurity>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>0</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>I</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value>By Spouse</value>
			</natureOfOwnership>
		</ownershipNature>
	</derivativeSecurity>
	<footnotes>
		<footnote id="F1">On June 30, 2003 all outstanding shares of Genzyme Biosurgery and Genzyme Molecular stock were exchanged for shares of Genzyme General Stock.  Genzyme Biosurgery shareholders received .04914 of a share of Genzyme General stock for each Biosurgery share and Genzyme Molecular Oncology shareholders received .05653 of a share of Genzyme General stock for each Molecular Oncology share.</footnote>
		<footnote id="F2">The sales reported were effected pursuant to a Rule 10b5-1 trading plan adpoted by the reporting person on June 16, 2003.</footnote>
		<footnote id="F3">On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.</footnote>
		<footnote id="F4">Options vest in 1/3 increments on December 8, 1994, March 14, 1996 and March 4, 1997</footnote>
		<footnote id="F5">Options vest in 20% annual increments beginning 12/16/94.</footnote>
		<footnote id="F6">Options vest in 25% annual increments on July 17, 2001, 2002, 2003 and 2004.</footnote>
		<footnote id="F7">Options vest in 20% annual increments beginning on the original date of grant.</footnote>
		<footnote id="F8">These options have a converted exercise price of $1,055.82 per share.</footnote>
		<footnote id="F9">The exercise of this stock option resulted in a distribution of 125 shares of Genzyme Biosurgery Division common stock.  In connection with the formation of Genzyme Biosurgery in December 2000, shares of Genzyme Tissue Repair were converted at a rate of 0.3352 of a share of Genzyme Biosugery for each share of Genzyme Tissue Repair.  The original distribution of Genzyme Tissue Repair was paid on July 22, 1997 to Genzyme General Division stockholders at a rate of 0.015.</footnote>
		<footnote id="F10">Options were granted with an exercise price 100% above fair market value, and vest in 1/3 increments on each of Janary 25, 2001, 2002 and 2003.</footnote>
		<footnote id="F11">Options vest in 1/3 annual increments beginning on the second year anniversary of the date of grant.</footnote>
		<footnote id="F12">Options vest 20% on October 16, 1997 and in 20% annual increments beginning May 16, 1998.</footnote>
	</footnotes>
	<ownerSignature>
		<signatureName>By: Susan P. Cogswell, Attorney-in-Fact</signatureName>
		<signatureDate>2003-07-02</signatureDate>
	</ownerSignature>
</ownershipDocument>
[{"type": "4", "sequence": "1", "filename": "van47.xml", "secsgml_size_bytes": 65086}]
X0101
4
2003-06-30
0
0000732485
GENZYME CORP
GENZ
0001021040
VAN HEEK G JAN
0
1
0
0
Executive Vice President
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
4980
0
D
0
D
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
497
0
D
0
I
By 401(k)
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
430
0
D
0
I
By 401(k) by spouse
Genzyme Biosurgery common stock (GZBX)
2003-06-30
4
J
0
558
0
D
0
I
By Spouse
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
244
0
A
2578
D
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
123
0
A
2701
D
Genzyme General common stock (GENZ)
2003-06-30
2003-06-30
4
M
0
25000
7.27
A
27701
D
Genzyme General common stock (GENZ)
2003-06-30
2003-06-30
4
S
0
25000
43.11
D
2701
D
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
24
0
A
806
I
By 401(k)
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
21
0
A
1664
I
By 401(k) by spouse
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
27
0
A
3532
I
By Spouse
Genzyme General common stock (GENZ)
2003-06-30
4
J
0
2
0
A
3534
I
By Spouse
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
4
J
0
2181
0
D
0
D
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
4
J
0
5
0
D
0
I
By 401(k)
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
4
J
0
5
0
D
0
I
By 401(k) by spouse
Genzyme Molecular Oncology common stock (GZMO)
2003-06-30
4
J
0
42
0
D
0
I
By Spouse
Biosurgery NQ stock option (right to buy)
15.12
2003-06-30
4
J
0
1131
0
D
2003-06-30
2003-12-08
Genzyme Biosurgery common stock (GZBX)
1131
0
D
Biosurgery NQ stock option (right to buy)
14.10
2003-06-30
4
J
0
452
0
D
1994-12-08
2004-12-08
Genzyme Biosurgery common stock (GZBX)
452
0
D
Biosurgery NQ stock option (right to buy)
14.17
2003-06-30
4
J
0
5028
0
D
1994-12-16
2004-12-16
Genzyme Biosurgery common stock (GZBX)
5028
0
D
Biosurgery NQ stock option (right to buy)
52.21
2003-06-30
4
J
0
7448
0
D
2005-06-30
2005-12-15
Genzyme Biosurgery common stock (GZBX)
7448
0
D
Biosurgery NQ stock option (right to buy)
6.69
2003-06-30
4
J
0
8157
0
D
2001-07-17
2011-02-09
Genzyme Biosurgery common stock (GZBX)
8157
0
D
Biosurgery NQ stock option (right to buy)
4.24
2003-06-30
4
J
0
26700
0
D
2002-05-30
2012-05-30
Genzyme Biosurgery common stock (GZBX)
26700
0
D
Genzyme General NQ stock option (right to buy)
305.77
2003-06-30
4
J
0
55
0
A
2003-06-30
2003-12-08
Genzyme General common stock (GENZ)
55
55
D
Genzyme General NQ stock option (right to buy)
7.27
2003-06-30
2003-06-30
4
M
0
25000
7.27
D
2003-06-30
2003-12-08
Genzyme General common stock (GENZ)
25000
75000
D
Genzyme General NQ stock option (right to buy)
285.14
2003-06-30
4
J
0
22
0
A
1994-12-08
2004-12-08
Genzyme General common stock (GENZ)
22
22
D
Genzyme General NQ stock option (right to buy)
286.56
2003-06-30
4
J
0
248
0
A
1994-12-16
2004-12-16
Genzyme General common stock (GENZ)
248
248
D
Genzyme General NQ stock option (right to buy)
0.00
2003-06-30
4
J
0
368
0
A
2005-06-30
2005-12-15
Genzyme General common stock (GENZ)
368
368
D
Genzyme General NQ stock option (right to buy)
124.69
2003-06-30
4
J
0
421
0
A
1997-10-16
2007-10-16
Genzyme General common stock (GENZ)
421
421
D
Genzyme General NQ stock option (right to buy)
124.69
2003-06-30
4
J
0
259
0
A
1998-05-28
2008-05-28
Genzyme General common stock (GENZ)
259
259
D
Genzyme General NQ stock option (right to buy)
95.84
2003-06-30
4
J
0
1573
0
A
2001-01-25
2009-01-25
Genzyme General common stock (GENZ)
1573
1573
D
Genzyme General NQ stock option (right to buy)
226.76
2003-06-30
4
J
0
468
0
A
2000-05-25
2010-05-25
Genzyme General common stock (GENZ)
468
468
D
Genzyme General NQ stock option (right to buy)
135.29
2003-06-30
4
J
0
403
0
A
2001-07-17
2011-02-09
Genzyme General common stock (GENZ)
403
403
D
Genzyme General NQ stock option (right to buy)
274.32
2003-06-30
4
J
0
505
0
A
2001-05-31
2011-05-31
Genzyme General common stock (GENZ)
505
505
D
Genzyme General NQ stock option (right to buy)
85.75
2003-06-30
4
J
0
1320
0
A
2002-05-30
2012-05-30
Genzyme General common stock (GENZ)
1320
1320
D
Genzyme General NQ stock option (right to buy)
41.51
2003-06-30
4
J
0
651
0
A
2002-05-30
2012-05-30
Genzyme General common stock (GENZ)
651
651
D
Genzyme General NQ stock option (right to buy)
478.27
2003-06-30
4
J
0
634
0
A
2002-03-24
2010-03-24
Genzyme General common stock (GENZ)
634
634
I
By Spouse
Genzyme General NQ stock option (right to buy)
226.76
2003-06-30
4
J
0
228
0
A
2000-05-25
2010-05-25
Genzyme General common stock (GENZ)
228
228
I
By Spouse
Molecular Oncology NQ stock option (right to buy)
7.00
2003-06-30
4
J
0
7500
0
D
1997-10-16
2007-10-16
Genzyme Molecular Oncology common stock (GZMO)
7500
0
D
Molecular Oncology NQ stock option (right to buy)
7.00
2003-06-30
4
J
0
4625
0
D
1998-05-28
2008-05-28
Genzyme Molecular Oncology common stock (GZMO)
4625
0
D
Molecular Oncology NQ stock option (right to buy)
5.38
2003-06-30
4
J
0
28027
0
D
2001-01-25
2009-01-25
Genzyme Molecular Oncology common stock (GZMO)
28027
0
D
Molecular Oncology NQ stock option (right to buy)
12.73
2003-06-30
4
J
0
8345
0
D
2000-05-25
2010-05-25
Genzyme Molecular Oncology common stock (GZMO)
8345
0
D
Molecular Oncology NQ stock option (right to buy)
15.40
2003-06-30
4
J
0
9000
0
D
2001-05-31
2011-05-31
Genzyme Molecular Oncology common stock (GZMO)
9000
0
D
Molecular Oncology NQ stock option (right to buy)
2.33
2003-06-30
4
J
0
11600
0
D
2002-05-30
2012-05-30
Genzyme Molecular Oncology common stock (GZMO)
11600
0
D
Molecular Oncology NQ Stock Option (right to buy)
26.85
2003-06-30
4
J
0
11302
0
D
2002-03-24
2010-03-24
Genzyme Molecular Oncology common stock (GZMO)
11302
0
I
By Spouse
Molecular Oncology NQ stock option (right to buy)
12.73
2003-06-30
4
J
0
4063
0
D
2000-05-25
2010-05-25
Genzyme Molecular Oncology common stock (GZMO)
4063
0
I
By Spouse
On June 30, 2003 all outstanding shares of Genzyme Biosurgery and Genzyme Molecular stock were exchanged for shares of Genzyme General Stock.  Genzyme Biosurgery shareholders received .04914 of a share of Genzyme General stock for each Biosurgery share and Genzyme Molecular Oncology shareholders received .05653 of a share of Genzyme General stock for each Molecular Oncology share.
The sales reported were effected pursuant to a Rule 10b5-1 trading plan adpoted by the reporting person on June 16, 2003.
On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.
Options vest in 1/3 increments on December 8, 1994, March 14, 1996 and March 4, 1997
Options vest in 20% annual increments beginning 12/16/94.
Options vest in 25% annual increments on July 17, 2001, 2002, 2003 and 2004.
Options vest in 20% annual increments beginning on the original date of grant.
These options have a converted exercise price of $1,055.82 per share.
The exercise of this stock option resulted in a distribution of 125 shares of Genzyme Biosurgery Division common stock.  In connection with the formation of Genzyme Biosurgery in December 2000, shares of Genzyme Tissue Repair were converted at a rate of 0.3352 of a share of Genzyme Biosugery for each share of Genzyme Tissue Repair.  The original distribution of Genzyme Tissue Repair was paid on July 22, 1997 to Genzyme General Division stockholders at a rate of 0.015.
Options were granted with an exercise price 100% above fair market value, and vest in 1/3 increments on each of Janary 25, 2001, 2002 and 2003.
Options vest in 1/3 annual increments beginning on the second year anniversary of the date of grant.
Options vest 20% on October 16, 1997 and in 20% annual increments beginning May 16, 1998.
By: Susan P. Cogswell, Attorney-in-Fact
2003-07-02