<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2024-11-19</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000109177</issuerCik>
        <issuerName>Spectrum Brands Holdings, Inc.</issuerName>
        <issuerTradingSymbol>SPB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001231601</rptOwnerCik>
            <rptOwnerName>POLISTINA TERRY</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SPECTRUM BRANDS HOLDINGS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>3001 DEMING WAY</rptOwnerStreet2>
            <rptOwnerCity>MIDDLETON</rptOwnerCity>
            <rptOwnerState>WI</rptOwnerState>
            <rptOwnerZipCode>53562</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2024-11-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3379</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>90.26</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>50740</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Reporting Person was awarded restricted stock units which are settled in shares of common stock of the Issuer and which are scheduled to vest on October 1, 2025 if Reporting Person is a director of the Issuer on such date.</footnote>
    </footnotes>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Laurel McKellips, Attorney-in-fact for Terry Polistina</signatureName>
        <signatureDate>2024-11-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
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X0508
4
2024-11-19
0
0000109177
Spectrum Brands Holdings, Inc.
SPB
0001231601
POLISTINA TERRY
C/O SPECTRUM BRANDS HOLDINGS, INC.
3001 DEMING WAY
MIDDLETON
WI
53562
1
0
0
0
0
Common Stock
2024-11-19
4
A
0
3379
90.26
A
50740
D
Reporting Person was awarded restricted stock units which are settled in shares of common stock of the Issuer and which are scheduled to vest on October 1, 2025 if Reporting Person is a director of the Issuer on such date.
Exhibit 24 - Power of Attorney
/s/ Laurel McKellips, Attorney-in-fact for Terry Polistina
2024-11-20