<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-06-14</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000725058</issuerCik>
        <issuerName>CYTOGEN CORP</issuerName>
        <issuerTradingSymbol>CYTO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001211250</rptOwnerCik>
            <rptOwnerName>GOECKELER WILLIAM F</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>650 COLLEGE ROAD EAST</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3100</rptOwnerStreet2>
            <rptOwnerCity>PRINCETON</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08540-5308</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Senior VP, Operations</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, $0.01 par value per share</value>
            </securityTitle>
            <transactionDate>
                <value>2005-06-14</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>12000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>13027</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Options to purchase common stock</value>
                <footnoteId id="F3"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>5.15</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-06-14</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>18000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2006-06-14</value>
            </exerciseDate>
            <expirationDate>
                <value>2015-06-14</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>18000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>18000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Such shares of restricted common stock were issued as a long-term incentive pursuant to the terms of the Company's 2004 Stock
Incentive Plan and vest over a period of six years.</footnote>
        <footnote id="F2">Includes 537 shares of common stock acquired under the Company's Employee Stock Purchase Plan.</footnote>
        <footnote id="F3">Such options were granted pursuant to the terms of the Company's 2004 Stock Incentive Plan and vest in three equal annual
installments beginning on the first anniversary of the date of grant.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ William F. Goeckeler</signatureName>
        <signatureDate>2005-06-16</signatureDate>
    </ownerSignature>
</ownershipDocument>
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X0202
4
2005-06-14
0
0000725058
CYTOGEN CORP
CYTO
0001211250
GOECKELER WILLIAM F
650 COLLEGE ROAD EAST
SUITE 3100
PRINCETON
NJ
08540-5308
0
1
0
0
Senior VP, Operations
Common Stock, $0.01 par value per share
2005-06-14
4
A
0
12000
0
A
13027
D
Options to purchase common stock
5.15
2005-06-14
4
A
0
18000
0
A
2006-06-14
2015-06-14
Common Stock
18000
18000
D
Such shares of restricted common stock were issued as a long-term incentive pursuant to the terms of the Company's 2004 Stock
Incentive Plan and vest over a period of six years.
Includes 537 shares of common stock acquired under the Company's Employee Stock Purchase Plan.
Such options were granted pursuant to the terms of the Company's 2004 Stock Incentive Plan and vest in three equal annual
installments beginning on the first anniversary of the date of grant.
/s/ William F. Goeckeler
2005-06-16