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  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">Registration No.&nbsp;333-<u>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt; margin-top: 6pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>Molecular Insight Pharmaceuticals, Inc.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Massachusetts</B><BR>
  (State or other jurisdiction of <BR>
  incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-0562086</B><BR>
  (I.R.S. Employer<BR>
  Identification No.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><B>160 Second Street <BR>
  Cambridge, MA</B><BR>
  (Address of principal executive offices)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><br><B>02142</B><BR>
  (Zip Code)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Molecular Insight Pharmaceuticals, Inc.<BR>
  Amended and Restated 2006 Equity Incentive Plan</B><BR>
  (Full title of the plans)</DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>John W. Babich</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Copy to:</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><B>President and Chief Executive Officer <BR>
  160 Second Street <BR>
  Cambridge, MA 02142<BR>
  (617)&nbsp;492-5554<BR>
  (617)&nbsp;492-5664 &#151; Fax</B><BR>
  (Name, address, including zip code, and telephone number, <BR>
  including area code, of agent for service)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>Gabor Garai<BR>
  David W. Kantaros<BR>
  Foley &#038; Lardner LLP<BR>
  111 Huntington Avenue<BR>
  Boston, Massachusetts 02199<BR>
  (617)&nbsp;342-4000<BR>
  (617)&nbsp;342-4001 &#151; Fax</B></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Indicate by check mark whether
  the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company.
  See the definitions of &#147;large accelerated filer,&#148; &#147;accelerated filer&#148; and &#147;smaller reporting
  company&#148; in Rule 12b-2 of the Exchange Act. (Check one):
  </DIV>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 0pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<TABLE width="100%" style="font-size: 10pt; margin-top: 0pt">
  <TR><TD valign="top">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Large accelerated filer&nbsp;<FONT face="Wingdings">&#111;</FONT></TD>
  <TD valign="top" align="center">Accelerated filer&nbsp;<FONT face="Wingdings">&#254;</FONT>&nbsp;</TD>
  <TD align="center">Non-accelerated filer&nbsp;<FONT face="Wingdings">&#111;</FONT><BR>(Do not check if a smaller reporting company)</TD>
  <TD valign="top" align="right">Smaller reporting company&nbsp;<FONT face="Wingdings">&#111;</FONT></TD></TR></TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 0pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></div>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">CALCULATION OF REGISTRATION FEE
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom" style="font-size: 1pt">
      <TD width="1%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="21" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="left">Title of Securities</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Offering Price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Aggregate Offering</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="left">to be Registered</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Registered (1)</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Per Share (3)</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Price (3)</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Registration Fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD valign="top" style="border-top: 2px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Common Stock,
  $.01 par value
  </DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="left" valign="top" style="border-top: 2px solid #000000">1,002,776 shares (2)
  </TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="center" valign="top" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 2px solid #000000">$1.85</TD>
      <TD nowrap valign="top" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" valign="top" style="border-top: 2px solid #000000">1,855,136</TD>
      <TD nowrap valign="top" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" valign="top" style="border-top: 2px solid #000000">72.91</TD>
      <TD nowrap valign="top" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="21" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>The provisions of Rule&nbsp;416 under the Securities Act of 1933, as amended shall apply to this
  Registration Statement and the number of shares registered on this Registration Statement shall
  increase or decrease as a result of stock splits, stock dividends, or similar transactions.
  Includes an indeterminate number of additional shares that may be issued to adjust the number of
  shares issued pursuant to the Plan described herein as the result of any future stock split, stock
  dividend, or similar adjustment of Registrant&#146;s outstanding common stock.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Represents 1,002,776 additional shares issuable pursuant to the grant or exercise of awards
  under the Registrant&#146;s Amended and Restated 2006 Equity Incentive Plan, which represents an
  automatic increase effective January&nbsp;1, 2009 equal to 4.0% of the total outstanding shares of the
  Registrant&#146;s common stock as of December&nbsp;31, 2008.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of calculating the registration fee. The fee is calculated
  pursuant to Rules 457(c) and 457(h) under the Securities Act of 1933 upon the basis of the average
  between the high and low sales prices for shares of common stock of the Registrant as reported on
  the Nasdaq Global Market on March&nbsp;6, 2009, which was $1.85.</TD>
  </TR>
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Explanatory Note</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Molecular Insight Pharmaceuticals, Inc. (the &#147;Company&#148; or &#147;Registrant&#148;) is filing this
  registration statement with the Securities and Exchange Commission (the &#147;Commission&#146;) to register
  an additional 1,002,776 shares of common stock of the Registrant reserved for issuance under the
  Registrant&#146;s Amended and Restated 2006 Equity Incentive Plan (the &#147;Plan&#148;), authorized pursuant to
  annual automatic increase provisions of the Plan for the 2009 fiscal year. This Registration
  Statement has been prepared in accordance with General Instruction E to Form S-8.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant has previously registered (i)&nbsp;2,300,000 shares of the Registrant&#146;s common stock
  for issuance under the Plan pursuant to a Registration Statement on Form S-8 filed on May&nbsp;17, 2007
  (File No.&nbsp;333-143065) and (ii)&nbsp;additional 998,126 shares of the Registrant&#146;s common stock for
  issuance under the Plan pursuant to a Registration Statement on Form S-8 files on August&nbsp;12, 2008
  (File No.&nbsp;333-152972).
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "PART I" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
  
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The contents of the Registrant&#146;s previously filed Registration Statement on Forms S-8 (File
  Nos. 333-143065 and 333-152972) relating to shares of common stock covered under the Registrant&#146;s
  Amended and Restated 2006 Equity Incentive Plan are hereby incorporated by reference.
  </DIV>
  <!-- link1 "PART II" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  </DIV>
  <!-- link2 "Item&nbsp;3. <U>Incorporation of Documents by Reference</U>." -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;3. <U>Incorporation of Documents by Reference</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents have been previously filed by the Registrant with the Commission and
  are incorporated herein by reference:
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31, 2008,
  filed with the Commission on March&nbsp;13, 2009;
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;The Registrant&#146;s Definitive Proxy Statement for an annual meeting of stockholders held on
  May&nbsp;12, 2008, filed with the Commission on April&nbsp;11, 2008;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;The Registrant&#146;s Current Reports on Form 8-K, filed with the
  Commission on January 5, 2009 and February&nbsp;2, 2009, respectively;
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;The section entitled &#147;Description of Registrant&#146;s Securities to be Registered&#148; contained
  in the Registrant&#146;s Registration Statement on Form 8-A, filed with the Commission pursuant to
  Section 12(b) of the Securities Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;) on January
  30, 2007, and any amendments or reports filed for the purpose of updating such description.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents subsequently filed by the Registrant pursuant to Sections
  13(a), 13(c), 14, or 15(d) of the Exchange Act, after the date of filing of this Registration
  Statement and prior to the filing of a post-effective amendment to this Registration Statement that
  indicates that all securities offered hereby have been sold or which deregisters all securities
  then remaining unsold, shall be deemed to be incorporated by reference into this Registration
  Statement and to be a part hereof from the date of filing of such reports and documents. The
  information contained in any such reports and documents will automatically update and supersede any
  information previously incorporated by reference into this Registration Statement. Any such
  information so modified or superseded shall not be deemed, except as so modified or superseded, to
  constitute part of this Registration Statement.
  </DIV>
  <!-- link2 "Item&nbsp;4. <U>Description of Securities</U>." -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;4. <U>Description of Securities</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;5. <U>Interests of Named Experts and Counsel</U>." -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;5. <U>Interests of Named Experts and Counsel</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->2<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link2 "Item&nbsp;6. <U>Indemnification of Directors and Officers</U>." -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;6. <U>Indemnification of Directors and Officers</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We are a Massachusetts corporation. Section&nbsp;2.02 of the Massachusetts Business Corporation
  Act, or MBCA, permits a corporation to eliminate or limit the personal liability of a director for
  monetary damages for violations of the director&#146;s fiduciary duty, except for (i)&nbsp;any breach of the
  director&#146;s duty of loyalty to the corporation or its stockholders, (ii)&nbsp;any acts or omissions not
  in good faith or which involve intentional misconduct or a knowing violation of law, (iii)
  authorizing unauthorized distributions and making loans to directors, officers and certain
  shareholders pursuant to Section&nbsp;6.40 of the MBCA, or (iv)&nbsp;any transaction from which a director
  derived an improper personal benefit.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;8 of the MBCA provides that a corporation may indemnify directors, officers, employees
  and other agents and persons who serve at its request as directors, officers, employees or agents
  of another organization or who serve at its request in any capacity with respect to any employee
  benefit plan, to the extent specified or authorized by the articles of organization, any bylaw
  adopted by the stockholders or a vote adopted by the holders of a majority of the shares of stock
  entitled to vote on the election of directors. Such indemnification may include payment by the
  corporation of expenses incurred in defending a civil or criminal action or proceeding in advance
  of the final disposition of such action or proceeding, upon receipt of any undertaking by the
  person indemnified to repay such payment if he shall be adjudicated to be not entitled to
  indemnification under Section&nbsp;8 which undertaking may be accepted without reference to the
  financial ability of such person to make repayment. Any such indemnification may be provided
  although the person to be indemnified is no longer an officer, director, employee or agent of the
  corporation or of such other organization or no longer serves with respect to such employee benefit
  plan. No indemnification shall be provided, however, for any person with respect to any matter
  where there is a court determination that such person, in the matter in question, did not act in
  good faith in the reasonable belief that his action was in the best interest of the corporation or,
  to the extent that the matter relates to service with respect to an employee benefit plan, that
  such person did not act in the best interest of the participants or beneficiaries of such employee
  benefit plan.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We have also adopted provisions in our Restated Articles of Organization providing that our
  directors, officers, employees, and agents shall be indemnified to the fullest extent permitted by
  Massachusetts law. In addition to the indemnification granted to officers and directors under the
  MBCA, Article&nbsp;VI of our Restated Articles of Organization provides that each person who was or is
  made a party or is threatened to be made a party to or is otherwise involved in any action, suit or
  proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he
  or she is or was a director or an officer of the corporation or is or was serving at the request of
  the corporation as a director, officer, employee or agent of another corporation or of a
  partnership, joint venture, trust or other enterprise, including service with respect to an
  employee benefit plan, whether the basis of such proceeding is alleged action in an official
  capacity as a director, officer, employee or agent or in any other capacity while serving as a
  director, officer, employee or agent, shall be indemnified and held harmless by the corporation to
  the fullest extent authorized by the MBCA, as the same exists or may hereafter be amended against
  all expense, liability and loss (including attorneys&#146; fees, judgments, fines, ERISA excise taxes or
  penalties and amounts paid in settlement) reasonably incurred or suffered by such indemnitee in
  connection therewith.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The right to indemnification conferred in our Restated Articles of Organization includes, in
  the case of a director or officer at the level of vice president or above, and in the case of any
  other officer or any employee may include (in the discretion of the Board of Directors), the right
  to be paid by the Company the expenses incurred in defending any such proceeding in advance of its
  final disposition. The rights to indemnification and to the advancement of expenses conferred in
  our Restated Articles of Organization continue as to an indemnitee who has ceased to be a director,
  officer, employee or agent and inure to the benefit of the indemnitee&#146;s heirs, executors and
  administrators. We believe that these provisions are necessary to attract and retain qualified
  persons as directors and executive officers. Additionally, the Amended and Restated Bylaws permit
  us to secure insurance on behalf of any officer, director, employee, or other agent for any
  liability arising out of his or her actions in connection with their services to us, regardless of
  whether our articles or incorporation or bylaws permit such indemnification. We have obtained such
  insurance.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;There is no pending litigation or proceeding involving our directors, officers, employees or
  agents for which indemnification is sought, nor are we aware of any pending or threatened
  litigation that may result in claims for indemnification by any director, officer, employee or
  other agent.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->3<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link2 "Item&nbsp;7. <U>Exemption from Registration Claimed</U>." -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;7. <U>Exemption from Registration Claimed</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable.
  </DIV>
  <!-- link2 "Item&nbsp;8. <U>Exhibits</U>." -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;8. <U>Exhibits</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following exhibits have been filed (except where otherwise indicated) as part of this
  Registration Statement:
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="88%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B><I>Exhibit No.</I></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><I>Exhibit Description</I></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">4.1(1)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Specimen certificate representing the Common Stock</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">5.1</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Opinion of Foley &#038; Lardner LLP regarding legality of common stock</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">23.1</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Deloitte &#038; Touche LLP</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">23.2</TD>
      <TD nowrap valign="top">&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Foley &#038; Lardner LLP (contained in Exhibit&nbsp;5.1 hereto)</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">24.1</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Power of Attorney relating to subsequent amendments (included on
  the signature page to this Registration Statement)</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">99.1(2)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Molecular Insight Pharmaceuticals, Inc.&#146;s Amended and Restated
  2006 Equity Incentive Plan</DIV></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Incorporated by reference to Exhibit&nbsp;4.2 previously filed with the Registrant&#146;s
  Annual Report on Form 10-K for the year ended December&nbsp;31, 2008 as filed with the
  Commission on March&nbsp;13, 2009.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Incorporated by reference to Exhibit&nbsp;10.19 previously filed with the
  Registrant&#146;s Registration Statement on Form S-1 filed with the Commission, as amended
  (Registration No.&nbsp;333-129570), as declared effective on February&nbsp;1, 2007.</TD>
  </TR>
  
  </TABLE>
  
  
  <!-- link2 "Item&nbsp;9. <U>Undertakings</U>." -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;9. <U>Undertakings</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.&nbsp;The undersigned Registrant hereby undertakes:
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;To file, during any period in which offers or sales are being made, a post-effective
  amendment to this registration statement:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;To include any prospectus required by section 10(a)(3) of the Securities Act of 1933, as
  amended (the &#147;<U>Securities Act</U>&#148;);
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;To reflect in the prospectus any facts or events arising after the effective date of this
  registration statement (or the most recent post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the information set forth in this registration
  statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
  (if the total dollar value of securities offered would not exceed that which was registered) and
  any deviation from the low or high end of the estimated maximum offering range may be reflected in
  the form of prospectus filed with the Commission pursuant to Rule 424(b) of the Securities Act, if,
  in the aggregate, the changes in volume and price represent no more than a 20% change in the
  maximum aggregate offering price set forth in the &#147;Calculation of Registration Fee&#148; table in this
  Registration Statement; and
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;To include any material information with respect to the plan of distribution not
  previously disclosed in this Registration Statement or any material change to such information in
  this Registration Statement.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->4<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;PROVIDED, HOWEVER, that paragraphs (a)(i) and (a)(ii) above do not apply if the registration
  statement is on Form S-8 and the information required to be included in a post-effective amendment
  by those paragraphs is contained in periodic reports filed with or furnished to the Commission by
  the Registrant pursuant to Section&nbsp;13 or Section 15(d) of the Exchange Act that are incorporated by
  reference herein.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;That, for the purpose of determining any liability under the Securities Act, each such
  post-effective amendment shall be deemed to be a new registration statement relating to the
  securities offered herein, and the offering of such securities at that time shall be deemed to be
  the initial bona fide offering thereof.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;The undersigned Registrant hereby undertakes that, for purposes of determining any
  liability under the Securities Act, each filing of the registrant&#146;s annual report pursuant to
  Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an
  employee benefit plan&#146;s annual report pursuant to section 15(d) of the Exchange Act) that is
  incorporated by reference in the Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered herein, and the offering of such securities at that
  time shall be deemed to be the initial bona fide offering thereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.&nbsp;Insofar as indemnification for liabilities arising under the Securities Act may be
  permitted to directors, officers and controlling persons of the registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Commission such indemnification is against public policy as expressed in the Securities Act and is,
  therefore, unenforceable. In the event that a claim for indemnification against such liabilities
  (other than the payment by the registrant of expenses incurred or paid by a director, officer or
  controlling person of the Registrant in the successful defense of any action, suit or proceeding)
  is asserted by such director, officer or controlling person in connection with the securities being
  registered, the Registrant will, unless in the opinion of its counsel the matter has been settled
  by controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities Act and will be
  governed by the final adjudication of such issue.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->5<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
  certifies that it has reasonable grounds to believe that it meets all the requirements for filing
  on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the
  undersigned, thereunto duly authorized, in the City of Boston, and Commonwealth of Massachusetts,
  on this 13th day of March, 2009.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD nowrap colspan="3" align="left">MOLECULAR INSIGHT PHARMACEUTICALS, INC.<br>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
  
  <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/
  John W. Babich, Ph.D.
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">John W. Babich, Ph.D.&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">President and Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY AND SIGNATURES</B>
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints John W. Babich his true and
  lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him/her
  in his/her name, place and stead, in any and all capacities, to sign any and all amendments
  (including post-effective amendments) to this Registration Statement and any Rule 462(b)
  Registration Statement and to file the same, with all exhibits thereto, and other documents in
  connection therewith, with the Securities and Exchange Commission, granting unto said
  attorney-in-fact and agent full power and authority to do and perform each and every act and thing
  requisite and necessary to be done in connection therewith, as fully to all intents and purposes as
  he/she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact
  and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration
  Statement has been signed by the following persons in the capacities below on the 13th day of
  March, 2009.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B><I>Signature</I></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><I>Title</I></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
  
  <TD align="left" nowrap valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ John W. Babich, Ph.D.
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  John W. Babich, Ph.D.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director; President and Chief Executive Officer (Principal Executive
  Officer)</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Paul A. Looney
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Paul A. Looney</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Chief Operating Officer</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Donald E. Wallroth
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Donald E. Wallroth</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Chief Financial Officer (Principal Financial
  Officer and Principal Accounting Officer)</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Anthony Martin, Ph.D.
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Anthony Martin, Ph.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director; Chairman of the Board of Directors</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ David Epstein
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  David Epstein</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Daniel Frank
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Daniel Frank</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->6<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "Signature" -->
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B><I>Signature</I></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><I>Title</I></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Scott Gottlieb, M.D.
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Scott Gottlieb, M.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Yvonne Greenstreet, M.D.
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Yvonne Greenstreet, M.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Joseph Limber
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Joseph Limber</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ David M. Stack
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  David M. Stack</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Lionel Sterling
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Lionel Sterling</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Harry Stylli, Ph.D.
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Harry Stylli, Ph.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->7<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "EXHIBIT INDEX" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXHIBIT INDEX</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="88%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B><I>Exhibit No.</I></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><I>Exhibit Description</I></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">4.1(1)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Specimen certificate representing the Common Stock</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">5.1</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Opinion of Foley &#038; Lardner LLP regarding legality of common stock</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">23.1</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Deloitte &#038; Touche LLP</DIV></TD>
  </TR>
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      <TD nowrap align="right" valign="top">&nbsp;</TD>
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  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">23.2</TD>
      <TD nowrap valign="top">&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Foley &#038; Lardner LLP (contained in Exhibit&nbsp;5.1 hereto)</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">24.1</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Power of Attorney relating to subsequent amendments (included on
  the signature page to this Registration Statement)</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">99.1(2)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Molecular Insight Pharmaceuticals, Inc.&#146;s Amended and Restated
  2006 Equity Incentive Plan</DIV></TD>
  </TR>
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      <TD>&nbsp;</TD>
      <TD>Incorporated by reference to Exhibit&nbsp;4.2 previously filed with the Registrant&#146;s Annual Report
  on Form 10-K for the year ended December&nbsp;31, 2008 as filed with the Commission on March&nbsp;13,
  2009.</TD>
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      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Incorporated by reference to Exhibit&nbsp;10.19 previously filed with the Registrant&#146;s
  Registration Statement on Form S-1 filed with the Commission, as amended (Registration No.
  333-129570), as declared effective on February&nbsp;1, 2007.</TD>
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text: sv8
  Registration No. 333-
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
  Molecular Insight Pharmaceuticals, Inc.
  (Exact name of registrant as specified in its charter)
  Massachusetts
  (State or other jurisdiction of
  incorporation or organization)
  04-0562086
  (I.R.S. Employer
  Identification No.)
  160 Second Street
  Cambridge, MA
  (Address of principal executive offices)
  02142
  (Zip Code)
  Molecular Insight Pharmaceuticals, Inc.
  Amended and Restated 2006 Equity Incentive Plan
  (Full title of the plans)
  John W. Babich
  Copy to:
  President and Chief Executive Officer
  160 Second Street
  Cambridge, MA 02142
  (617) 492-5554
  (617) 492-5664 — Fax
  (Name, address, including zip code, and telephone number,
  including area code, of agent for service)
  Gabor Garai
  David W. Kantaros
  Foley & Lardner LLP
  111 Huntington Avenue
  Boston, Massachusetts 02199
  (617) 342-4000
  (617) 342-4001 — Fax
  Indicate by check mark whether
  the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company.
  See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting
  company" in Rule 12b-2 of the Exchange Act. (Check one):
  Large accelerated filer
  o
  Accelerated filer
  þ
  Non-accelerated filer
  o
  (Do not check if a smaller reporting company)
  Smaller reporting company
  o
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  Maximum
  Maximum
  Title of Securities
  Amount to be
  Offering Price
  Aggregate Offering
  Amount of
  to be Registered
  Registered (1)
  Per Share (3)
  Price (3)
  Registration Fee
  Common Stock,
  $.01 par value
  1,002,776 shares (2)
  $1.85
  $
  1,855,136
  $
  72.91
  (1)
  The provisions of Rule 416 under the Securities Act of 1933, as amended shall apply to this
  Registration Statement and the number of shares registered on this Registration Statement shall
  increase or decrease as a result of stock splits, stock dividends, or similar transactions.
  Includes an indeterminate number of additional shares that may be issued to adjust the number of
  shares issued pursuant to the Plan described herein as the result of any future stock split, stock
  dividend, or similar adjustment of Registrant's outstanding common stock.
  (2)
  Represents 1,002,776 additional shares issuable pursuant to the grant or exercise of awards
  under the Registrant's Amended and Restated 2006 Equity Incentive Plan, which represents an
  automatic increase effective January 1, 2009 equal to 4.0% of the total outstanding shares of the
  Registrant's common stock as of December 31, 2008.
  (3)
  Estimated solely for the purpose of calculating the registration fee. The fee is calculated
  pursuant to Rules 457(c) and 457(h) under the Securities Act of 1933 upon the basis of the average
  between the high and low sales prices for shares of common stock of the Registrant as reported on
  the Nasdaq Global Market on March 6, 2009, which was $1.85.
  Explanatory Note
  Molecular Insight Pharmaceuticals, Inc. (the "Company" or "Registrant") is filing this
  registration statement with the Securities and Exchange Commission (the "Commission') to register
  an additional 1,002,776 shares of common stock of the Registrant reserved for issuance under the
  Registrant's Amended and Restated 2006 Equity Incentive Plan (the "Plan"), authorized pursuant to
  annual automatic increase provisions of the Plan for the 2009 fiscal year. This Registration
  Statement has been prepared in accordance with General Instruction E to Form S-8.
  The Registrant has previously registered (i) 2,300,000 shares of the Registrant's common stock
  for issuance under the Plan pursuant to a Registration Statement on Form S-8 filed on May 17, 2007
  (File No. 333-143065) and (ii) additional 998,126 shares of the Registrant's common stock for
  issuance under the Plan pursuant to a Registration Statement on Form S-8 files on August 12, 2008
  (File No. 333-152972).
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  The contents of the Registrant's previously filed Registration Statement on Forms S-8 (File
  Nos. 333-143065 and 333-152972) relating to shares of common stock covered under the Registrant's
  Amended and Restated 2006 Equity Incentive Plan are hereby incorporated by reference.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference
  .
  The following documents have been previously filed by the Registrant with the Commission and
  are incorporated herein by reference:
  (a) The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2008,
  filed with the Commission on March 13, 2009;
  (b) The Registrant's Definitive Proxy Statement for an annual meeting of stockholders held on
  May 12, 2008, filed with the Commission on April 11, 2008;
  (c) The Registrant's Current Reports on Form 8-K, filed with the
  Commission on January 5, 2009 and February 2, 2009, respectively;
  (d) The section entitled "Description of Registrant's Securities to be Registered" contained
  in the Registrant's Registration Statement on Form 8-A, filed with the Commission pursuant to
  Section 12(b) of the Securities Exchange Act of 1934, as amended (the "Exchange Act") on January
  30, 2007, and any amendments or reports filed for the purpose of updating such description.
  All reports and other documents subsequently filed by the Registrant pursuant to Sections
  13(a), 13(c), 14, or 15(d) of the Exchange Act, after the date of filing of this Registration
  Statement and prior to the filing of a post-effective amendment to this Registration Statement that
  indicates that all securities offered hereby have been sold or which deregisters all securities
  then remaining unsold, shall be deemed to be incorporated by reference into this Registration
  Statement and to be a part hereof from the date of filing of such reports and documents. The
  information contained in any such reports and documents will automatically update and supersede any
  information previously incorporated by reference into this Registration Statement. Any such
  information so modified or superseded shall not be deemed, except as so modified or superseded, to
  constitute part of this Registration Statement.
  Item 4.
  Description of Securities
  .
  Not applicable.
  Item 5.
  Interests of Named Experts and Counsel
  .
  Not applicable.
  2
  Item 6.
  Indemnification of Directors and Officers
  .
  We are a Massachusetts corporation. Section 2.02 of the Massachusetts Business Corporation
  Act, or MBCA, permits a corporation to eliminate or limit the personal liability of a director for
  monetary damages for violations of the director's fiduciary duty, except for (i) any breach of the
  director's duty of loyalty to the corporation or its stockholders, (ii) any acts or omissions not
  in good faith or which involve intentional misconduct or a knowing violation of law, (iii)
  authorizing unauthorized distributions and making loans to directors, officers and certain
  shareholders pursuant to Section 6.40 of the MBCA, or (iv) any transaction from which a director
  derived an improper personal benefit.
  Section 8 of the MBCA provides that a corporation may indemnify directors, officers, employees
  and other agents and persons who serve at its request as directors, officers, employees or agents
  of another organization or who serve at its request in any capacity with respect to any employee
  benefit plan, to the extent specified or authorized by the articles of organization, any bylaw
  adopted by the stockholders or a vote adopted by the holders of a majority of the shares of stock
  entitled to vote on the election of directors. Such indemnification may include payment by the
  corporation of expenses incurred in defending a civil or criminal action or proceeding in advance
  of the final disposition of such action or proceeding, upon receipt of any undertaking by the
  person indemnified to repay such payment if he shall be adjudicated to be not entitled to
  indemnification under Section 8 which undertaking may be accepted without reference to the
  financial ability of such person to make repayment. Any such indemnification may be provided
  although the person to be indemnified is no longer an officer, director, employee or agent of the
  corporation or of such other organization or no longer serves with respect to such employee benefit
  plan. No indemnification shall be provided, however, for any person with respect to any matter
  where there is a court determination that such person, in the matter in question, did not act in
  good faith in the reasonable belief that his action was in the best interest of the corporation or,
  to the extent that the matter relates to service with respect to an employee benefit plan, that
  such person did not act in the best interest of the participants or beneficiaries of such employee
  benefit plan.
  We have also adopted provisions in our Restated Articles of Organization providing that our
  directors, officers, employees, and agents shall be indemnified to the fullest extent permitted by
  Massachusetts law. In addition to the indemnification granted to officers and directors under the
  MBCA, Article VI of our Restated Articles of Organization provides that each person who was or is
  made a party or is threatened to be made a party to or is otherwise involved in any action, suit or
  proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he
  or she is or was a director or an officer of the corporation or is or was serving at the request of
  the corporation as a director, officer, employee or agent of another corporation or of a
  partnership, joint venture, trust or other enterprise, including service with respect to an
  employee benefit plan, whether the basis of such proceeding is alleged action in an official
  capacity as a director, officer, employee or agent or in any other capacity while serving as a
  director, officer, employee or agent, shall be indemnified and held harmless by the corporation to
  the fullest extent authorized by the MBCA, as the same exists or may hereafter be amended against
  all expense, liability and loss (including attorneys' fees, judgments, fines, ERISA excise taxes or
  penalties and amounts paid in settlement) reasonably incurred or suffered by such indemnitee in
  connection therewith.
  The right to indemnification conferred in our Restated Articles of Organization includes, in
  the case of a director or officer at the level of vice president or above, and in the case of any
  other officer or any employee may include (in the discretion of the Board of Directors), the right
  to be paid by the Company the expenses incurred in defending any such proceeding in advance of its
  final disposition. The rights to indemnification and to the advancement of expenses conferred in
  our Restated Articles of Organization continue as to an indemnitee who has ceased to be a director,
  officer, employee or agent and inure to the benefit of the indemnitee's heirs, executors and
  administrators. We believe that these provisions are necessary to attract and retain qualified
  persons as directors and executive officers. Additionally, the Amended and Restated Bylaws permit
  us to secure insurance on behalf of any officer, director, employee, or other agent for any
  liability arising out of his or her actions in connection with their services to us, regardless of
  whether our articles or incorporation or bylaws permit such indemnification. We have obtained such
  insurance.
  There is no pending litigation or proceeding involving our directors, officers, employees or
  agents for which indemnification is sought, nor are we aware of any pending or threatened
  litigation that may result in claims for indemnification by any director, officer, employee or
  other agent.
  3
  Item 7.
  Exemption from Registration Claimed
  .
  Not Applicable.
  Item 8.
  Exhibits
  .
  The following exhibits have been filed (except where otherwise indicated) as part of this
  Registration Statement:
  Exhibit No.
  Exhibit Description
  4.1(1)
  Specimen certificate representing the Common Stock
  5.1
  Opinion of Foley & Lardner LLP regarding legality of common stock
  23.1
  Consent of Deloitte & Touche LLP
  23.2
  Consent of Foley & Lardner LLP (contained in Exhibit 5.1 hereto)
  24.1
  Power of Attorney relating to subsequent amendments (included on
  the signature page to this Registration Statement)
  99.1(2)
  Molecular Insight Pharmaceuticals, Inc.'s Amended and Restated
  2006 Equity Incentive Plan
  (1)
  Incorporated by reference to Exhibit 4.2 previously filed with the Registrant's
  Annual Report on Form 10-K for the year ended December 31, 2008 as filed with the
  Commission on March 13, 2009.
  (2)
  Incorporated by reference to Exhibit 10.19 previously filed with the
  Registrant's Registration Statement on Form S-1 filed with the Commission, as amended
  (Registration No. 333-129570), as declared effective on February 1, 2007.
  Item 9.
  Undertakings
  .
  1. The undersigned Registrant hereby undertakes:
  (a) To file, during any period in which offers or sales are being made, a post-effective
  amendment to this registration statement:
  (i) To include any prospectus required by section 10(a)(3) of the Securities Act of 1933, as
  amended (the "
  Securities Act
  ");
  (ii) To reflect in the prospectus any facts or events arising after the effective date of this
  registration statement (or the most recent post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the information set forth in this registration
  statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
  (if the total dollar value of securities offered would not exceed that which was registered) and
  any deviation from the low or high end of the estimated maximum offering range may be reflected in
  the form of prospectus filed with the Commission pursuant to Rule 424(b) of the Securities Act, if,
  in the aggregate, the changes in volume and price represent no more than a 20% change in the
  maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in this
  Registration Statement; and
  (iii) To include any material information with respect to the plan of distribution not
  previously disclosed in this Registration Statement or any material change to such information in
  this Registration Statement.
  4
  PROVIDED, HOWEVER, that paragraphs (a)(i) and (a)(ii) above do not apply if the registration
  statement is on Form S-8 and the information required to be included in a post-effective amendment
  by those paragraphs is contained in periodic reports filed with or furnished to the Commission by
  the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by
  reference herein.
  (b) That, for the purpose of determining any liability under the Securities Act, each such
  post-effective amendment shall be deemed to be a new registration statement relating to the
  securities offered herein, and the offering of such securities at that time shall be deemed to be
  the initial bona fide offering thereof.
  (c) To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  2. The undersigned Registrant hereby undertakes that, for purposes of determining any
  liability under the Securities Act, each filing of the registrant's annual report pursuant to
  Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an
  employee benefit plan's annual report pursuant to section 15(d) of the Exchange Act) that is
  incorporated by reference in the Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered herein, and the offering of such securities at that
  time shall be deemed to be the initial bona fide offering thereof.
  3. Insofar as indemnification for liabilities arising under the Securities Act may be
  permitted to directors, officers and controlling persons of the registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Commission such indemnification is against public policy as expressed in the Securities Act and is,
  therefore, unenforceable. In the event that a claim for indemnification against such liabilities
  (other than the payment by the registrant of expenses incurred or paid by a director, officer or
  controlling person of the Registrant in the successful defense of any action, suit or proceeding)
  is asserted by such director, officer or controlling person in connection with the securities being
  registered, the Registrant will, unless in the opinion of its counsel the matter has been settled
  by controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities Act and will be
  governed by the final adjudication of such issue.
  5
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
  certifies that it has reasonable grounds to believe that it meets all the requirements for filing
  on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the
  undersigned, thereunto duly authorized, in the City of Boston, and Commonwealth of Massachusetts,
  on this 13th day of March, 2009.
  MOLECULAR INSIGHT PHARMACEUTICALS, INC.
  By:
  /s/
  John W. Babich, Ph.D.
  John W. Babich, Ph.D.
  President and Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  Each person whose signature appears below constitutes and appoints John W. Babich his true and
  lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him/her
  in his/her name, place and stead, in any and all capacities, to sign any and all amendments
  (including post-effective amendments) to this Registration Statement and any Rule 462(b)
  Registration Statement and to file the same, with all exhibits thereto, and other documents in
  connection therewith, with the Securities and Exchange Commission, granting unto said
  attorney-in-fact and agent full power and authority to do and perform each and every act and thing
  requisite and necessary to be done in connection therewith, as fully to all intents and purposes as
  he/she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact
  and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration
  Statement has been signed by the following persons in the capacities below on the 13th day of
  March, 2009.
  Signature
  Title
  /s/ John W. Babich, Ph.D.
  John W. Babich, Ph.D.
  Director; President and Chief Executive Officer (Principal Executive
  Officer)
  /s/ Paul A. Looney
  Paul A. Looney
  Chief Operating Officer
  /s/ Donald E. Wallroth
  Donald E. Wallroth
  Chief Financial Officer (Principal Financial
  Officer and Principal Accounting Officer)
  /s/ Anthony Martin, Ph.D.
  Anthony Martin, Ph.D.
  Director; Chairman of the Board of Directors
  /s/ David Epstein
  David Epstein
  Director
  /s/ Daniel Frank
  Daniel Frank
  Director
  6
  Signature
  Title
  /s/ Scott Gottlieb, M.D.
  Scott Gottlieb, M.D.
  Director
  /s/ Yvonne Greenstreet, M.D.
  Yvonne Greenstreet, M.D.
  Director
  /s/ Joseph Limber
  Joseph Limber
  Director
  /s/ David M. Stack
  David M. Stack
  Director
  /s/ Lionel Sterling
  Lionel Sterling
  Director
  /s/ Harry Stylli, Ph.D.
  Harry Stylli, Ph.D.
  Director
  7
  EXHIBIT INDEX
  Exhibit No.
  Exhibit Description
  4.1(1)
  Specimen certificate representing the Common Stock
  5.1
  Opinion of Foley & Lardner LLP regarding legality of common stock
  23.1
  Consent of Deloitte & Touche LLP
  23.2
  Consent of Foley & Lardner LLP (contained in Exhibit 5.1 hereto)
  24.1
  Power of Attorney relating to subsequent amendments (included on
  the signature page to this Registration Statement)
  99.1(2)
  Molecular Insight Pharmaceuticals, Inc.'s Amended and Restated
  2006 Equity Incentive Plan
  (1)
  Incorporated by reference to Exhibit 4.2 previously filed with the Registrant's Annual Report
  on Form 10-K for the year ended December 31, 2008 as filed with the Commission on March 13,
  2009.
  (2)
  Incorporated by reference to Exhibit 10.19 previously filed with the Registrant's
  Registration Statement on Form S-1 filed with the Commission, as amended (Registration No.
  333-129570), as declared effective on February 1, 2007.
  8