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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">As filed with the Securities and Exchange Commission on October&nbsp;20, 2008</DIV>
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">Registration No.&nbsp;333-<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT UNDER</b><BR>
  <b>THE SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>ASPECT MEDICAL SYSTEMS, INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact Name of Registrant as Specified in Its Charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B><BR>
  (State or Other Jurisdiction of <BR>
  Incorporation or Organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-2985553</B><BR>
  (I.R.S. Employer<BR>
  Identification No.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><B>One Upland Road, Norwood, Massachusetts</B><BR>
  (Address of Principal Executive Offices)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>02062</B><BR>
  (Zip Code)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>2001 STOCK INCENTIVE PLAN</B><BR>
  (Full Title of the Plan)<BR>
  <B>Nassib G. Chamoun<BR>
  President and Chief Executive Officer<BR>
  Aspect Medical Systems, Inc.<BR>
  One Upland Road<BR>
  Norwood, Massachusetts 02062</B><BR>
  (Name and Address of Agent For Service)<BR>
  <B>(617)&nbsp;559-7000</B><BR>
  (Telephone Number, Including Area Code, of Agent For Service)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">With copy to:<BR>
  <B>Susan W. Murley, Esq.<BR>
  Wilmer Cutler Pickering Hale and Dorr LLP<BR>
  60 State Street<BR>
  Boston, Massachusetts 02109<BR>
  (617)&nbsp;526-6000<BR>
  CALCULATION OF REGISTRATION FEE</B></DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of Each Class</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Proposed Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Proposed Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">of Securities to be Registered</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Registered(1)</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Offering Price Per Share</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Aggregate Offering Price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Registration Fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
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      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Common Stock, $0.01 par value
  per share (including the
  associated Series&nbsp;A Junior
  Participating Preferred Stock
  purchase rights)</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">700,000 shares</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$3.92(2)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$2,744,000(2)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$108</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
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  </DIV>
  
  
  
  <DIV style="margin-top: 3pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>In accordance with Rule&nbsp;416 under the Securities Act of 1933, as
  amended, this registration statement shall be deemed to cover any
  additional securities that may from time to time be offered or issued
  to prevent dilution resulting from stock splits, stock dividends or
  similar transactions.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of calculating the registration fee
  pursuant to Rules 457(c) and 457(h) of the Securities Act of 1933, as
  amended, and based upon the average of the high and low prices of the
  Registrant&#146;s Common Stock as reported on The Nasdaq Global Market on
  October&nbsp;15, 2008.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
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  	<TD width="76%"></TD>
  </TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#000">Item&nbsp;3. Incorporation of Documents by Reference.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;8. Exhibits.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#004">INDEX TO EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b72575amexv5w1.htm">Ex-5.1 Opinion of Wilmer Cutler Pickering Hale and Dorr LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b72575amexv23w2.htm">Ex-23.2 Consent of Ernst & Young LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Statement of Incorporation by Reference</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement on Form S-8 is being filed for the purpose of registering
  additional securities of the same class as other securities for which a Registration Statement on
  Form S-8 has previously been filed and is effective. Accordingly, this Registration Statement on
  Form S-8 incorporates by reference the contents of the Registration Statement on Form S-8, File No.
  333-86048, filed by the Registrant on April&nbsp;11, 2002, the Registration Statement on Form S-8, File
  No.&nbsp;333-124728, filed by the Registrant on May&nbsp;9, 2005 and the Registration Statement on Form S-8,
  File No.&nbsp;333-148376, filed by the Registrant on December&nbsp;28, 2007 each relating to the Registrant&#146;s
  2001 Stock Incentive Plan, except for Item&nbsp;3, Incorporation of Documents by Reference, Item&nbsp;5,
  Interests of Named Experts and Counsel and Item&nbsp;8, Exhibits.
  </DIV>
  <!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference." -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Item&nbsp;3. Incorporation of Documents by Reference.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant is subject to the informational and reporting requirements of Sections&nbsp;13(a),
  14, and 15(d) of the Securities Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;), and in
  accordance therewith files reports, proxy statements and other information with the Securities and
  Exchange Commission (the &#147;Commission&#148;). The following documents, which are on file with the
  Commission, are incorporated in this registration statement by reference:
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The Registrant&#146;s latest annual report filed pursuant to Section 13(a) or 15(d) of the
  Exchange Act or the latest prospectus filed pursuant to Rule 424(b) under the Securities Act that
  contains audited financial statements for the Registrant&#146;s latest fiscal year for which such
  statements have been filed.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the
  end of the fiscal year covered by the document referred to in (a)&nbsp;above.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;The description of the securities contained in the Registrant&#146;s registration statements on
  Form 8-A filed under the Exchange Act, including any amendment or report filed for the purpose of
  updating such description.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents subsequently filed by the Registrant pursuant to Sections&nbsp;13(a), 13(c), 14 and
  15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that
  all securities offered hereby have been sold or which deregisters all securities then remaining
  unsold, shall be deemed to be incorporated by reference in this registration statement and to be
  part hereof from the date of the filing of such documents. Any statement contained in a document
  incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or
  superseded for the purposes of this registration statement to the extent that a statement contained
  herein or in any other subsequently filed document which also is or is deemed to be incorporated by
  reference herein modifies or supersedes such statement. Any statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this registration
  statement.
  </DIV>
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Wilmer Cutler Pickering Hale and Dorr LLP has opined as to the legality of the securities
  being offered by this registration statement. Certain attorneys at Wilmer Cutler Pickering Hale and
  Dorr LLP own shares of the Registrant&#146;s Common Stock.
  </DIV>
  <!-- link2 "Item&nbsp;8. Exhibits." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Item&nbsp;8. Exhibits.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Exhibit&nbsp;Index immediately preceding the exhibits is incorporated herein by reference.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  
  
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this registration statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Norwood, Massachusetts, on this 20<SUP style="font-size: 85%; vertical-align: text-top">th</SUP> day of October, 2008.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">ASPECT MEDICAL SYSTEMS, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Nassib G. Chamoun
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Nassib G. Chamoun&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">President and Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY AND SIGNATURES</B>
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We, the undersigned officers and directors of Aspect Medical Systems, Inc., hereby severally
  constitute and appoint Nassib G. Chamoun, J. Breckenridge Eagle and Michael Falvey, and each of
  them singly, our true and lawful attorneys with full power to them, and each of them singly, to
  sign for us and in our names in the capacities indicated below, the registration statement on Form
  S-8 filed herewith and any and all subsequent amendments to said registration statement, and
  generally to do all such things in our names and on our behalf in our capacities as officers and
  directors to enable Aspect Medical Systems, Inc. to comply with the provisions of the Securities
  Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby
  ratifying and confirming our signatures as they may be signed by our said attorneys, or any of
  them, to said registration statement and any and all amendments thereto.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this registration statement has
  been signed by the following persons in the capacities and on the dates indicated.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="35%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="19%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Nassib G. Chamoun
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Nassib G. Chamoun
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">President, Chief Executive Officer and Director
  <br>(Principal Executive Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ J. Breckenridge Eagle
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  J. Breckenridge Eagle
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chairman of the Board of Directors&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Michael Falvey
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Michael Falvey
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Vice President and Chief Financial Officer
  <br>(Principal Financial and Accounting Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Boudewijn L.P.M. Bollen
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Boudewijn L.P.M. Bollen
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Michael A. Esposito
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Michael A. Esposito
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ David Feigal, M.D.
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  David Feigal, M.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Edwin M. Kania
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Edwin M. Kania
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ James J. Mahoney, Jr.
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  James J. Mahoney, Jr.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ John J. O&#146;Connor
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  John J. O&#146;Connor
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Donald R. Stanski, M.D.
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Donald R. Stanski, M.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">October&nbsp;20, 2008</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->-4-<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link1 "INDEX TO EXHIBITS" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX TO EXHIBITS</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="92%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1(1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2(2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated By-Laws of the Registrant, as amended</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3(3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement dated November&nbsp;29, 2004 between the Registrant and EquiServe
  Trust Company, N.A., as rights agent</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4(4)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amendment No.&nbsp;1, dated as of May&nbsp;23, 2005, to the Rights Agreement, dated as of
  November&nbsp;29, 2004, between the Registrant and EquiServe Trust Company, N.A., as
  rights agent.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amendment No.&nbsp;2, dated as of November&nbsp;1, 2007, to the Rights Agreement, dated as
  of November&nbsp;29, 2004, between the Registrant and EquiServe Trust Company, N.A.,
  as rights agent.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.6(6)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amendment No.&nbsp;3 to Rights Agreement, dated as of June&nbsp;2, 2008, between Aspect
  Medical Systems, Inc. and Computershare Trust Company, N.A.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Registrant</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit&nbsp;5.1)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of attorney (included on the signature pages of this registration statement)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Previously filed with the Securities and Exchange Commission as
  Exhibit&nbsp;3.1 to the Registrant&#146;s Registration Statement on Form S-1, as
  amended (File No.&nbsp;333-86295), and incorporated herein by reference.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Previously filed with the Securities and Exchange Commission as
  Exhibit&nbsp;3.1 to the Registrant&#146;s Current Report on Form 8-K as filed
  with the Securities and Exchange Commission on November&nbsp;5, 2007 (File
  No.&nbsp;000-24663), and incorporated herein by reference.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>Previously filed with the Securities and Exchange Commission as
  Exhibit&nbsp;4.1 to the Registrant&#146;s Current Report on Form 8-K filed on
  December&nbsp;1, 2004 (File No.&nbsp;000-24663), and incorporated herein by
  reference.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(4)</TD>
      <TD>&nbsp;</TD>
      <TD>Previously field with the Securities and Exchange Commission as
  Exhibit&nbsp;2 to the Registrant&#146;s Registration Statement on form 8-A/A
  filed on May&nbsp;23, 2005 (File No.&nbsp;000-24663), and incorporated herein by
  reference.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(5)</TD>
      <TD>&nbsp;</TD>
      <TD>Previously field with the Securities and Exchange Commission as
  Exhibit&nbsp;3 to the Registrant&#146;s Registration Statement on form 8-A/A
  filed on November&nbsp;7, 2007 (File No.&nbsp;000-24663), and incorporated
  herein by reference.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(6)</TD>
      <TD>&nbsp;</TD>
      <TD>Previously field with the Securities and Exchange Commission as
  Exhibit&nbsp;4 to the Registrant&#146;s Registration Statement on form 8-A/A
  filed on June&nbsp;2, 2008 (File No.&nbsp;000-24663), and incorporated herein by
  reference.</TD>
  </TR>
  
  </TABLE>
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio --><!-- /Folio -->
  </DIV>
  
  
  
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on October 20, 2008
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER
  THE SECURITIES ACT OF 1933
  ASPECT MEDICAL SYSTEMS, INC.
  (Exact Name of Registrant as Specified in Its Charter)
  Delaware
  (State or Other Jurisdiction of
  Incorporation or Organization)
  04-2985553
  (I.R.S. Employer
  Identification No.)
  One Upland Road, Norwood, Massachusetts
  (Address of Principal Executive Offices)
  02062
  (Zip Code)
  2001 STOCK INCENTIVE PLAN
  (Full Title of the Plan)
  Nassib G. Chamoun
  President and Chief Executive Officer
  Aspect Medical Systems, Inc.
  One Upland Road
  Norwood, Massachusetts 02062
  (Name and Address of Agent For Service)
  (617) 559-7000
  (Telephone Number, Including Area Code, of Agent For Service)
  With copy to:
  Susan W. Murley, Esq.
  Wilmer Cutler Pickering Hale and Dorr LLP
  60 State Street
  Boston, Massachusetts 02109
  (617) 526-6000
  CALCULATION OF REGISTRATION FEE
  Title of Each Class
  Amount to be
  Proposed Maximum
  Proposed Maximum
  Amount of
  of Securities to be Registered
  Registered(1)
  Offering Price Per Share
  Aggregate Offering Price
  Registration Fee
  Common Stock, $0.01 par value
  per share (including the
  associated Series A Junior
  Participating Preferred Stock
  purchase rights)
  700,000 shares
  $3.92(2)
  $2,744,000(2)
  $108
  (1)
  In accordance with Rule 416 under the Securities Act of 1933, as
  amended, this registration statement shall be deemed to cover any
  additional securities that may from time to time be offered or issued
  to prevent dilution resulting from stock splits, stock dividends or
  similar transactions.
  (2)
  Estimated solely for the purpose of calculating the registration fee
  pursuant to Rules 457(c) and 457(h) of the Securities Act of 1933, as
  amended, and based upon the average of the high and low prices of the
  Registrant's Common Stock as reported on The Nasdaq Global Market on
  October 15, 2008.
  TABLE OF CONTENTS
  Item 3. Incorporation of Documents by Reference.
  Item 5. Interests of Named Experts and Counsel.
  Item 8. Exhibits.
  SIGNATURES
  INDEX TO EXHIBITS
  Ex-5.1 Opinion of Wilmer Cutler Pickering Hale and Dorr LLP
  Ex-23.2 Consent of Ernst & Young LLP
  Table of Contents
  Statement of Incorporation by Reference
  This Registration Statement on Form S-8 is being filed for the purpose of registering
  additional securities of the same class as other securities for which a Registration Statement on
  Form S-8 has previously been filed and is effective. Accordingly, this Registration Statement on
  Form S-8 incorporates by reference the contents of the Registration Statement on Form S-8, File No.
  333-86048, filed by the Registrant on April 11, 2002, the Registration Statement on Form S-8, File
  No. 333-124728, filed by the Registrant on May 9, 2005 and the Registration Statement on Form S-8,
  File No. 333-148376, filed by the Registrant on December 28, 2007 each relating to the Registrant's
  2001 Stock Incentive Plan, except for Item 3, Incorporation of Documents by Reference, Item 5,
  Interests of Named Experts and Counsel and Item 8, Exhibits.
  Item 3. Incorporation of Documents by Reference.
  The Registrant is subject to the informational and reporting requirements of Sections 13(a),
  14, and 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and in
  accordance therewith files reports, proxy statements and other information with the Securities and
  Exchange Commission (the "Commission"). The following documents, which are on file with the
  Commission, are incorporated in this registration statement by reference:
  (a) The Registrant's latest annual report filed pursuant to Section 13(a) or 15(d) of the
  Exchange Act or the latest prospectus filed pursuant to Rule 424(b) under the Securities Act that
  contains audited financial statements for the Registrant's latest fiscal year for which such
  statements have been filed.
  (b) All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the
  end of the fiscal year covered by the document referred to in (a) above.
  (c) The description of the securities contained in the Registrant's registration statements on
  Form 8-A filed under the Exchange Act, including any amendment or report filed for the purpose of
  updating such description.
  All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and
  15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that
  all securities offered hereby have been sold or which deregisters all securities then remaining
  unsold, shall be deemed to be incorporated by reference in this registration statement and to be
  part hereof from the date of the filing of such documents. Any statement contained in a document
  incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or
  superseded for the purposes of this registration statement to the extent that a statement contained
  herein or in any other subsequently filed document which also is or is deemed to be incorporated by
  reference herein modifies or supersedes such statement. Any statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this registration
  statement.
  Item 5. Interests of Named Experts and Counsel.
  Wilmer Cutler Pickering Hale and Dorr LLP has opined as to the legality of the securities
  being offered by this registration statement. Certain attorneys at Wilmer Cutler Pickering Hale and
  Dorr LLP own shares of the Registrant's Common Stock.
  Item 8. Exhibits.
  The Exhibit Index immediately preceding the exhibits is incorporated herein by reference.
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this registration statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Norwood, Massachusetts, on this 20
  th
  day of October, 2008.
  ASPECT MEDICAL SYSTEMS, INC.
  By:
  /s/ Nassib G. Chamoun
  Nassib G. Chamoun
  President and Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  We, the undersigned officers and directors of Aspect Medical Systems, Inc., hereby severally
  constitute and appoint Nassib G. Chamoun, J. Breckenridge Eagle and Michael Falvey, and each of
  them singly, our true and lawful attorneys with full power to them, and each of them singly, to
  sign for us and in our names in the capacities indicated below, the registration statement on Form
  S-8 filed herewith and any and all subsequent amendments to said registration statement, and
  generally to do all such things in our names and on our behalf in our capacities as officers and
  directors to enable Aspect Medical Systems, Inc. to comply with the provisions of the Securities
  Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby
  ratifying and confirming our signatures as they may be signed by our said attorneys, or any of
  them, to said registration statement and any and all amendments thereto.
  Pursuant to the requirements of the Securities Act of 1933, this registration statement has
  been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Nassib G. Chamoun
  Nassib G. Chamoun
  President, Chief Executive Officer and Director
  (Principal Executive Officer)
  October 20, 2008
  /s/ J. Breckenridge Eagle
  J. Breckenridge Eagle
  Chairman of the Board of Directors
  October 20, 2008
  /s/ Michael Falvey
  Michael Falvey
  Vice President and Chief Financial Officer
  (Principal Financial and Accounting Officer)
  October 20, 2008
  /s/ Boudewijn L.P.M. Bollen
  Boudewijn L.P.M. Bollen
  Director
  October 20, 2008
  /s/ Michael A. Esposito
  Michael A. Esposito
  Director
  October 20, 2008
  /s/ David Feigal, M.D.
  David Feigal, M.D.
  Director
  October 20, 2008
  /s/ Edwin M. Kania
  Edwin M. Kania
  Director
  October 20, 2008
  /s/ James J. Mahoney, Jr.
  James J. Mahoney, Jr.
  Director
  October 20, 2008
  /s/ John J. O'Connor
  John J. O'Connor
  Director
  October 20, 2008
  /s/ Donald R. Stanski, M.D.
  Donald R. Stanski, M.D.
  Director
  October 20, 2008
  -4-
  Table of Contents
  INDEX TO EXHIBITS
  Number
  Description
  4.1(1)
  Restated Certificate of Incorporation of the Registrant
  4.2(2)
  Amended and Restated By-Laws of the Registrant, as amended
  4.3(3)
  Rights Agreement dated November 29, 2004 between the Registrant and EquiServe
  Trust Company, N.A., as rights agent
  4.4(4)
  Amendment No. 1, dated as of May 23, 2005, to the Rights Agreement, dated as of
  November 29, 2004, between the Registrant and EquiServe Trust Company, N.A., as
  rights agent.
  4.5(5)
  Amendment No. 2, dated as of November 1, 2007, to the Rights Agreement, dated as
  of November 29, 2004, between the Registrant and EquiServe Trust Company, N.A.,
  as rights agent.
  4.6(6)
  Amendment No. 3 to Rights Agreement, dated as of June 2, 2008, between Aspect
  Medical Systems, Inc. and Computershare Trust Company, N.A.
  5.1
  Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Registrant
  23.1
  Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1)
  23.2
  Consent of Ernst & Young LLP
  24.1
  Power of attorney (included on the signature pages of this registration statement)
  (1)
  Previously filed with the Securities and Exchange Commission as
  Exhibit 3.1 to the Registrant's Registration Statement on Form S-1, as
  amended (File No. 333-86295), and incorporated herein by reference.
  (2)
  Previously filed with the Securities and Exchange Commission as
  Exhibit 3.1 to the Registrant's Current Report on Form 8-K as filed
  with the Securities and Exchange Commission on November 5, 2007 (File
  No. 000-24663), and incorporated herein by reference.
  (3)
  Previously filed with the Securities and Exchange Commission as
  Exhibit 4.1 to the Registrant's Current Report on Form 8-K filed on
  December 1, 2004 (File No. 000-24663), and incorporated herein by
  reference.
  (4)
  Previously field with the Securities and Exchange Commission as
  Exhibit 2 to the Registrant's Registration Statement on form 8-A/A
  filed on May 23, 2005 (File No. 000-24663), and incorporated herein by
  reference.
  (5)
  Previously field with the Securities and Exchange Commission as
  Exhibit 3 to the Registrant's Registration Statement on form 8-A/A
  filed on November 7, 2007 (File No. 000-24663), and incorporated
  herein by reference.
  (6)
  Previously field with the Securities and Exchange Commission as
  Exhibit 4 to the Registrant's Registration Statement on form 8-A/A
  filed on June 2, 2008 (File No. 000-24663), and incorporated herein by
  reference.