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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <P align="center" style="font-size: 10pt"><B>As filed with the Securities and Exchange Commission on July&nbsp;20, 2005</B>
  
  
  
  <P align="right" style="font-size: 10pt"><B>REGISTRATION NO.</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  
  <P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, DC 20549</B>
  </DIV>
  
  <P align="center" style="font-size: 18pt"><B>FORM S-8</B>
  
  
  <P align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENT<BR>
  UNDER THE<BR>
  SECURITIES ACT OF 1933</B>
  
  
  <P align="center" style="font-size: 24pt"><B>BIOPURE CORPORATION</B>
  
  
  <DIV align="center" style="font-size: 10pt">(Exact Name of Registrant as Specified in Its Charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-2836871</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or Other Jurisdiction of Incorporation)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><B>11 Hurley Street, Cambridge, Massachusetts 02141</B><BR>
  (Address of Principal Executive Offices)
  
  
  
  <P align="center" style="font-size: 10pt"><B>2002 OMNIBUS SECURITIES AND INCENTIVE PLAN, AS AMENDED</B><BR>
  (Full Title of the Plan)
  
  
  
  <P align="center" style="font-size: 10pt"><B>JANE KOBER<BR>
  Senior Vice President<BR>
  Biopure Corporation<BR>
  11 Hurley Street<BR>
  Cambridge, Massachusetts<BR>
  (617)&nbsp;234-6500</B><BR>
  (Name, Address and Telephone Number of Agent for Service)
  
  
  
  <P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="20%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" colspan="9" style="border-bottom: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Proposed Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Proposed Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Title of Each Class of</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Amount To Be</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Offering Price</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Aggregate</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Amount of</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Securities to be Registered</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Registered(1)</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Per Share(2)</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Offering Price(2)</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Registration Fee</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD><DIV style="margin-left:15px; text-indent:-15px">Class&nbsp;A Common Stock(3)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">3,333,333 shares</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">$1.42</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">$4,733,333</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">$557.11</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="9" align="left" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>In addition, pursuant to Rule 416(a) under the Securities Act of 1933, this registration
  statement also covers any additional securities to be offered or issued in connection with a
  stock split, stock dividend or similar transaction.</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(h) under the Securities Act of 1933 as
  follows: the fee for the shares available for options not yet granted is calculated pursuant to Rule 457(c) under the
  Securities Act on the basis of the average of the high and low sale prices per share of the
  common stock on The Nasdaq Stock Market on July&nbsp;18, 2005.</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Including the associated preferred stock purchase rights.</TD>
  </TR>
  
  </TABLE>
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#000">ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">ITEM 8. EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#002">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003">INDEX TO EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55937bcexv5.htm">Ex-5 Opinion of Jane Kober</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55937bcexv23w2.htm">Ex-23.2 Consent of Ernst & Young LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><B>EXPLANATORY NOTE</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant hereby increases the number of shares of its common stock registered for
  issuance under its 2002 Omnibus Securities and Incentive Plan by 3,333,333 shares. Pursuant to
  Instruction E to Form S-8, the Registrant incorporates by reference into this Registration
  Statement the entire contents of its Registration Statement on Form S-8 (File No.&nbsp;333-114381) filed
  with the Securities and Exchange Commission on April&nbsp;9, 2004, other than Items 5 and 8.
  
  <!-- link2 "ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="left" style="font-size: 10pt">ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As of July&nbsp;19, 2005, Jane Kober, Esq., Senior Vice President, General Counsel and Secretary of
  the Company, held 2,215 shares of common stock and options to purchase 47,779 shares of common
  stock.
  
  <!-- link2 "ITEM 8. EXHIBITS" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="left" style="font-size: 10pt">ITEM 8. EXHIBITS
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;See Exhibit&nbsp;Index
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="center" style="font-size: 10pt">SIGNATURES
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, the registrant certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned thereunto
  duly authorized, in Cambridge, Massachusetts, on the 12<SUP style="font-size: 85%; vertical-align: text-top">th</SUP> day of July, 2005.
  
  
  <P align="center" style="font-size: 10pt">BIOPURE CORPORATION
  
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">                                              /s/ Francis H. Murphy
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Francis H. Murphy&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">CHIEF FINANCIAL OFFICER<BR>
  (Principal financial and accounting officer)&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <P align="center" style="font-size: 10pt">POWER OF ATTORNEY
  
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
  and appoints FRANCIS H. MURPHY and JANE KOBER, and each of them, as his or her true and lawful
  attorneys-in-fact and agents, with full power of substitution and resubstitution, for the
  undersigned and in his or her name, place and stead, in any and all capacities, to sign any or all
  amendments (including post-effective amendments) to the Registration Statement and to file the
  same, with all exhibits thereto, and all documents in connection therewith, with the Securities and
  Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power
  of authority to do and perform each and every act and thing requisite and necessary to be done in
  connection therewith, as fully to all intents and purposes as he or she might or could do in
  person, hereby ratifying and confirming all that said attorneys-in-fact and agents, each acting
  alone, or his or her substitute or substitutes, may lawfully do or cause to be done by virtue
  hereof.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, this Registration Statement has been
  signed below by the following persons in the capacities indicated and on July&nbsp;12, 2005.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="18%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="77%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="left" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Zafiris G. Zafirelis
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director, President and Chief Executive Officer</DIV></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">Zafiris G. Zafirelis
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(Principal executive officer)</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Francis H. Murphy
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Chief Financial Officer</DIV></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">Francis H. Murphy
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(Principal financial and accounting officer)</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top" nowrap>/s/ Charles A Sanders, M.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director and Chairman of the Board</DIV></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top" nowrap>Charles A. Sanders, M.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Daniel P. Harrington
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director</DIV></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">Daniel P. Harrington
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">II-1
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="18%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="77%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="left" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ David N. Judelson
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director</DIV></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">David N. Judelson
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ C. Everett Koop, M.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director</DIV></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">C. Everett Koop, M.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Jay B. Pieper
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director</DIV></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">Jay B. Pieper
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Carl W. Rausch
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director</DIV></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">Carl W. Rausch
  </TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">II-2
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "INDEX TO EXHIBITS" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="center" style="font-size: 10pt">INDEX TO EXHIBITS
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="5%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="90%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000">Description of Exhibit</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation<SUP style="font-size: 85%; vertical-align: text-top">*</SUP></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By-laws, as amended<SUP style="font-size: 85%; vertical-align: text-top">**</SUP></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Jane Kober</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Jane Kober (contained in Exhibit&nbsp;5)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (set forth on the signature page of this
  Registration Statement).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top">
      <TD width="3%" nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">*</SUP></TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="96%">Previously filed as an exhibit to the
  Registrant&#146;s Quarterly Report on Form 10-Q for the quarter ended April&nbsp;30, 2005
  (File No.&nbsp;001-15167) and incorporated herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="3%" nowrap align="left"><SUP style="font-size: 85%; vertical-align: text-top">**</SUP></TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="96%">Previously filed as an exhibit to the
  Registrant&#146;s Registration Statement No.&nbsp;333-78829 and incorporated herein
  by reference.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="center" style="font-size: 10pt">II-3
  </DIV>
  
  </BODY>
  </HTML>
metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "b55937bcsv8.htm", "description": "BIOPURE CORPORATION", "secsgml_size_bytes": 25342}]
metadata_filer: {"company-data": {"conformed-name": "BIOPURE CORP", "cik": "0000815508", "assigned-sic": "2836", "irs-number": "042836871", "state-of-incorporation": "DE", "fiscal-year-end": "1031"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-126735", "film-number": "05964238"}, "business-address": {"street1": "11 HURLEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02141", "phone": "6172346500"}, "mail-address": {"street1": "11 HURLEY STREET", "city": "CAMBRIDGE", "state": "MA", "zip": "02141"}}
text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on July 20, 2005
  REGISTRATION NO.
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, DC 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER THE
  SECURITIES ACT OF 1933
  BIOPURE CORPORATION
  (Exact Name of Registrant as Specified in Its Charter)
  Delaware
  04-2836871
  (State or Other Jurisdiction of Incorporation)
  (I.R.S. Employer Identification No.)
  11 Hurley Street, Cambridge, Massachusetts 02141
  (Address of Principal Executive Offices)
  2002 OMNIBUS SECURITIES AND INCENTIVE PLAN, AS AMENDED
  (Full Title of the Plan)
  JANE KOBER
  Senior Vice President
  Biopure Corporation
  11 Hurley Street
  Cambridge, Massachusetts
  (617) 234-6500
  (Name, Address and Telephone Number of Agent for Service)
  CALCULATION OF REGISTRATION FEE
  Proposed Maximum
  Proposed Maximum
  Title of Each Class of
  Amount To Be
  Offering Price
  Aggregate
  Amount of
  Securities to be Registered
  Registered(1)
  Per Share(2)
  Offering Price(2)
  Registration Fee
  Class A Common Stock(3)
  3,333,333 shares
  $1.42
  $4,733,333
  $557.11
  (1)
  In addition, pursuant to Rule 416(a) under the Securities Act of 1933, this registration
  statement also covers any additional securities to be offered or issued in connection with a
  stock split, stock dividend or similar transaction.
  (2)
  This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(h) under the Securities Act of 1933 as
  follows: the fee for the shares available for options not yet granted is calculated pursuant to Rule 457(c) under the
  Securities Act on the basis of the average of the high and low sale prices per share of the
  common stock on The Nasdaq Stock Market on July 18, 2005.
  (3)
  Including the associated preferred stock purchase rights.
  TABLE OF CONTENTS
  ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
  ITEM 8. EXHIBITS
  SIGNATURES
  INDEX TO EXHIBITS
  Ex-5 Opinion of Jane Kober
  Ex-23.2 Consent of Ernst & Young LLP
  Table of Contents
  EXPLANATORY NOTE
  The Registrant hereby increases the number of shares of its common stock registered for
  issuance under its 2002 Omnibus Securities and Incentive Plan by 3,333,333 shares. Pursuant to
  Instruction E to Form S-8, the Registrant incorporates by reference into this Registration
  Statement the entire contents of its Registration Statement on Form S-8 (File No. 333-114381) filed
  with the Securities and Exchange Commission on April 9, 2004, other than Items 5 and 8.
  ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
  As of July 19, 2005, Jane Kober, Esq., Senior Vice President, General Counsel and Secretary of
  the Company, held 2,215 shares of common stock and options to purchase 47,779 shares of common
  stock.
  ITEM 8. EXHIBITS
  See Exhibit Index
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act, the registrant certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned thereunto
  duly authorized, in Cambridge, Massachusetts, on the 12
  th
  day of July, 2005.
  BIOPURE CORPORATION
  By:
  /s/ Francis H. Murphy
  Francis H. Murphy
  CHIEF FINANCIAL OFFICER
  (Principal financial and accounting officer)
  POWER OF ATTORNEY
  KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
  and appoints FRANCIS H. MURPHY and JANE KOBER, and each of them, as his or her true and lawful
  attorneys-in-fact and agents, with full power of substitution and resubstitution, for the
  undersigned and in his or her name, place and stead, in any and all capacities, to sign any or all
  amendments (including post-effective amendments) to the Registration Statement and to file the
  same, with all exhibits thereto, and all documents in connection therewith, with the Securities and
  Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power
  of authority to do and perform each and every act and thing requisite and necessary to be done in
  connection therewith, as fully to all intents and purposes as he or she might or could do in
  person, hereby ratifying and confirming all that said attorneys-in-fact and agents, each acting
  alone, or his or her substitute or substitutes, may lawfully do or cause to be done by virtue
  hereof.
  Pursuant to the requirements of the Securities Act, this Registration Statement has been
  signed below by the following persons in the capacities indicated and on July 12, 2005.
  Signature
  Title
  /s/ Zafiris G. Zafirelis
  Director, President and Chief Executive Officer
  Zafiris G. Zafirelis
  (Principal executive officer)
  /s/ Francis H. Murphy
  Chief Financial Officer
  Francis H. Murphy
  (Principal financial and accounting officer)
  /s/ Charles A Sanders, M.D.
  Director and Chairman of the Board
  Charles A. Sanders, M.D.
  /s/ Daniel P. Harrington
  Director
  Daniel P. Harrington
  II-1
  Table of Contents
  Signature
  Title
  /s/ David N. Judelson
  Director
  David N. Judelson
  /s/ C. Everett Koop, M.D.
  Director
  C. Everett Koop, M.D.
  /s/ Jay B. Pieper
  Director
  Jay B. Pieper
  /s/ Carl W. Rausch
  Director
  Carl W. Rausch
  II-2
  Table of Contents
  INDEX TO EXHIBITS
  Number
  Description of Exhibit
  4.1
  Restated Certificate of Incorporation
  *
  4.2
  By-laws, as amended
  **
  5
  Opinion of Jane Kober
  23.1
  Consent of Jane Kober (contained in Exhibit 5)
  23.2
  Consent of Ernst & Young LLP
  24
  Power of Attorney (set forth on the signature page of this
  Registration Statement).
  *
  Previously filed as an exhibit to the
  Registrant's Quarterly Report on Form 10-Q for the quarter ended April 30, 2005
  (File No. 001-15167) and incorporated herein by reference.
  **
  Previously filed as an exhibit to the
  Registrant's Registration Statement No. 333-78829 and incorporated herein
  by reference.
  II-3