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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">As filed with the Securities and Exchange Commission on
  March 11, 2008
  </DIV>
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">REGISTRATION NO. 333 -
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT<BR>
  under the<BR>
  SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>ALTUS PHARMACEUTICALS INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(<I>Exact Name of Registrant as Specified in Its Charter)</I></DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B><BR>
  ( <I>State or Other Jurisdiction <BR>
  of Incorporation or Organization </I>)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-3573277</B><BR>
  ( <I>I.R.S. Employer<BR>
  Identification No. </I>)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>640 Memorial Drive<BR>
  Cambridge, MA 02139</B><BR>
  ( <I>Address, Including Zip Code, of Principal Executive Offices </I>)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended</B><BR>
  <I>(Full Title of the Plan)</I></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>David D. Pendergast, Ph.D.<BR>
  Executive Chairman<BR>
  Altus Pharmaceuticals Inc.<BR>
  640 Memorial Drive<BR>
  Cambridge, MA 02139<BR>
  (617)&nbsp;299-2900</B><BR>
  ( <I>Name, Address and Telephone Number, Including Area Code, of Agent For Service </I>)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">with copies to:<BR>
  <B>Jonathan L. Kravetz, Esq.<BR>
  Megan N. Gates, Esq.<BR>
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.<BR>
  One Financial Center<BR>
  Boston, Massachusetts 02111</B></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer,
  a non-accelerated filer, or a smaller reporting company. See the definitions of &#147;large accelerated filer,&#148; &#147;accelerated filer&#148; and &#147;smaller reporting company&#148; in
  Rule&nbsp;12b-2 of the Exchange Act. (Check one):
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="23%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="23%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="23%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="23%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top">Large accelerated filer&nbsp;<FONT face="Wingdings">&#111;</FONT>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Accelerated filer&nbsp;<FONT face="Wingdings">&#254;</FONT>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Non-accelerated filer&nbsp;<FONT face="Wingdings">&#111;</FONT>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Smaller reporting company&nbsp;<FONT face="Wingdings">&#111;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD colspan="5" align="center" valign="top">(Do not check if a smaller reporting company)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>CALCULATION OF REGISTRATION FEE</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">offering price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">aggregate</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">securities to be registered</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">registered<SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">per share<SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">offering price<SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">registration fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, $0.01 par value</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">1,144,157</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">5.61</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">6,418,721</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">252.26</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV style="margin-top: 3pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>The number of shares of Common Stock stated above consists of 1,144,157 additional shares which may be sold upon the exercise of options and the issuance of stock
  awards which may hereafter be granted under the Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended (the
  &#147;Plan&#148;). The maximum number of shares which may be sold upon the exercise of options or issuance of stock awards granted under the Plan is subject to adjustment in
  accordance with certain anti-dilution and other provisions of the Plan. Accordingly, pursuant to Rule&nbsp;416 under the Securities Act of 1933, as amended (the
  &#147;Securities Act&#148;), this Registration Statement covers, in addition to the number of shares stated above, an indeterminate number of shares which may be subject to
  grant or otherwise issuable upon the operation of any such anti-dilution and other provisions.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>This calculation is made solely for the purpose of determining the registration fee pursuant to the provisions of Rule 457(c) and (h)&nbsp;under the Securities Act. The
  fee is calculated on the basis of the average of the high and low sale prices per share of the Common Stock on The Nasdaq Global Market as of a date (March&nbsp;6, 2008)
  within five business days prior to filing this Registration Statement.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;1.</U> <U>Plan Information</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;2.</U> <U>Registrant Information and Employee Plan Annual Information</U>.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003">PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;3. Incorporation of Documents by Reference</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;4. Description of Securities</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;5. Interests of Named Experts and Counsel</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;6. Indemnification of Directors and Officers</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#008">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;7. Exemption from Registration Claimed</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#009">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;8. Exhibits</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#010">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;9. Undertakings</U>.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#011">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#012">INDEX OF EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b68988apexv5.htm">EX-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b68988apexv23w2.htm">EX-23.2 Consent of Deloitte & Touche LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXPLANATORY NOTE</B>
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">The contents of the previously filed Registration Statements on Form S-8 (File No.&nbsp;333-134421 and
  File No.&nbsp;333-145243) of the Registrant are hereby incorporated by reference. The purpose of this
  Form S-8 Registration Statement is to reflect an increase of 1,144,157 shares of Common Stock
  authorized for issuance under the Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee,
  Director and Consultant Stock Plan, as amended (the &#147;Plan&#148;).
  </DIV>
  <!-- link1 "PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
  
  </DIV>
  <!-- link2 "&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;1.</U> <U>Plan Information</U>." -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;1.</U> <U>Plan Information</U>.
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The information required by Item&nbsp;1 is included in documents sent or given by the Registrant to
  participants in the Plan covered by this Registration Statement pursuant to Rule&nbsp;428(b)(1) under
  the Securities Act.
  </DIV>
  <!-- link2 "&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;2.</U> <U>Registrant Information and Employee Plan Annual Information</U>." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;2.</U> <U>Registrant Information and Employee Plan Annual Information</U>.
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The written statement required by Item&nbsp;2 is included in documents sent or given by the
  Registrant to participants in the Plan covered by this Registration Statement pursuant to Rule
  428(b)(1) under the Securities Act.
  </DIV>
  <!-- link1 "PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  </DIV>
  <!-- link2 "&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;3. Incorporation of Documents by Reference</U>." -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;3. Incorporation of Documents by Reference</U>.
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31, 2007
  filed on March 11, 2008 (File No.&nbsp;000-51711);</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K filed on January&nbsp;30, 2008 (File No.&nbsp;000-51711);</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K filed on February&nbsp;7, 2008 (File No.&nbsp;000-51711);</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K filed on February&nbsp;28, 2008 (File No.&nbsp;000-51711);</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(5)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K filed on March&nbsp;11, 2008 (File No.&nbsp;000-51711); and</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(6)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Registrant&#146;s Common Stock contained in the Registrant&#146;s Registration
  Statement on Form 8-A, filed with the Commission on January&nbsp;11, 2006 (File No.&nbsp;000-51711),
  including any amendment or report filed for the purpose of updating such description.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, prior to the filing of
  a post-effective amendment which indicates that all securities offered hereby have been sold or
  which deregisters all securities then remaining unsold, shall be deemed to be incorporated by
  reference herein and to be part hereof from the date of filing of such reports and documents. Any
  statement contained in a document incorporated or deemed to be incorporated by reference herein
  shall be deemed to be modified or superseded for the purposes of this Registration Statement to the
  extent that a statement contained herein or in any other subsequently filed document which also is
  or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any
  statement so modified or superseded shall not be deemed, except as so modified or superseded, to
  constitute a part of this Registration Statement.
  </DIV>
  <!-- link2 "&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;4. Description of Securities</U>." -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;4. Description of Securities</U>.
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link2 "&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;5. Interests of Named Experts and Counsel</U>." -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;5. Interests of Named Experts and Counsel</U>.
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm, their families
  and trusts for their benefit own an aggregate of approximately 12,794 shares of Common Stock of the
  Registrant and options and warrants to purchase 1,000 shares of Common Stock of the Registrant.
  </DIV>
  <!-- link2 "&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;6. Indemnification of Directors and Officers</U>." -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;6. Indemnification of Directors and Officers</U>.
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporated herein by reference from Part&nbsp;II, Item&nbsp;15 &#147;Indemnification of Directors and
  Officers&#148; of the Registrant&#146;s Registration Statement on Form S-3 (File No.&nbsp;333-141414).
  </DIV>
  <!-- link2 "&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;7. Exemption from Registration Claimed</U>." -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;7. Exemption from Registration Claimed</U>.
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;8. Exhibits</U>." -->
  <DIV align="left"><A NAME="009"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;8. Exhibits</U>.
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4.1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Restated Certificate of Incorporation of the Registrant. Filed as Exhibit&nbsp;3.1 to the Registrant&#146;s Annual Report on Form 10-K for the fiscal
  year ended December&nbsp;31, 2006, as amended (File No.&nbsp;000-51711) and incorporated herein by reference.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4.2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Restated By-laws of the Registrant. Filed as Exhibit&nbsp;3.4 to the Registrant&#146;s Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4.3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Form of Common Stock Certificate. Filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4.4)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Amended and Restated Investor Rights Agreement, dated as of May&nbsp;21, 2004. Filed as Exhibit&nbsp;4.3 to the Registrant&#146;s Registration Statement on
  Form S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4.5)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Form of Common Stock Warrant to Adage Capital Partners, L.P. Filed as Exhibit&nbsp;4.5 to the Registrant&#146;s Registration Statement on Form S-3
  (File No.&nbsp;333-141414) and incorporated herein by reference.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4.6)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Form of Common Stock Warrant to Cystic Fibrosis Foundation Therapeutics, Inc. Filed as Exhibit&nbsp;4.9 to the Registrant&#146;s
  Registration Statement on Form S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4.7)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Form of Common Stock Warrant to Cowen and Company, LLC. Filed as Exhibit&nbsp;4.11 to the Registrant&#146;s Registration Statement on
  Form S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4.8)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Form of Series&nbsp;B Preferred Stock Warrant, as amended, together with a schedule of warrant holders. Filed as Exhibit&nbsp;4.12 to
  the Registrant&#146;s Registration Statement on Form S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(4.9)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Form of Series&nbsp;C Preferred Stock Warrant, together with a schedule of warrant holders. Filed as Exhibit&nbsp;4.13 to the
  Registrant&#146;s Registration Statement on Form S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(5)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares being registered. Filed herewith.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(23.1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(23.2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Consent of Deloitte &#038; Touche LLP. Filed herewith.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(24)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Power of Attorney to file future amendments (set forth on the signature page of this Registration Statement).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(99.1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended. Filed as</TD>
  </TR>
  
  
  </TABLE>
  </DIV>
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Exhibit&nbsp;10.4 to the Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31, 2006, as amended (File
  No.&nbsp;000-51711) and incorporated herein by reference.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <!-- link2 "&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Item&nbsp;9. Undertakings</U>." -->
  <DIV align="left"><A NAME="010"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  <U>Item&nbsp;9. Undertakings</U>.
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes:</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">(1)&nbsp;To file, during any period in which offers or sales are being made, a post-effective
  amendment to this Registration Statement:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 8%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act of 1933;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 8%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date of
  the Registration Statement (or the most recent post-effective amendment thereof) which,
  individually or in the aggregate, represent a fundamental change in the information set forth
  in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in
  volume of securities offered (if the total dollar value of securities offered would not exceed
  that which was registered) and any deviation from the low or high end of the estimated maximum
  offering range may be reflected in the form of prospectus filed with the Commission pursuant to
  Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20%
  change in the maximum aggregate offering price set forth in the &#147;Calculation of Registration
  Fee&#148; table in the effective Registration Statement.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 8%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution not
  previously disclosed in the Registration Statement or any material change to such information
  in the Registration Statement;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 8%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however </I>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information
  required to be included in a post-effective amendment by those paragraphs is contained in reports
  filed with or furnished to the Commission by the Registrant pursuant to Section&nbsp;13 or Section
  15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in this
  Registration Statement.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">(2)&nbsp;That, for the purpose of determining any liability under the Securities Act of 1933, each
  such post-effective amendment shall be deemed to be a new registration statement relating to the
  securities offered therein, and the offering of such securities at that time shall be deemed to
  be the initial bona fide offering thereof.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">(3)&nbsp;To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act of 1933, each
  filing of the Registrant&#146;s annual report pursuant to Section 13(a) or
  Section 15(d) of the Securities Exchange Act of 1934 that is
  incorporated by reference in this Registration Statement shall be
  deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Insofar as indemnification for liabilities arising under the
  Securities Act of 1933 may be permitted to directors, officers and
  controlling persons of the Registrant pursuant to the foregoing
  provisions, or otherwise, the Registrant has been advised that in the
  opinion of the Securities and Exchange Commission such indemnification
  is against public policy as expressed in the Act and is, therefore,
  unenforceable. In the event that a claim for indemnification against
  such liabilities (other than the payment by the Registrant of expenses
  incurred or paid by a director, officer or controlling person of the
  Registrant in the successful defense of any action, suit or
  proceeding) is asserted by such director, officer or controlling
  person in connection with the securities being registered, the
  Registrant will, unless in the opinion of its counsel the matter has
  been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by
  it is against public policy as expressed in the Act and will be
  governed by the final adjudication of such issue.</TD>
  </TR>
  
  
  </TABLE>
  </DIV>
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  
  </TABLE>
  </DIV>
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="011"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Cambridge, Massachusetts on March 11, 2008.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left"><FONT style="font-variant: SMALL-CAPS"><B>ALTUS PHARMACEUTICALS INC.</B></FONT><BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ David D. Pendergast, Ph.D.
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">David D. Pendergast, Ph.D.&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Executive Chairman&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">POWER OF ATTORNEY
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints David D. Pendergast,
  Jonathan I. Lieber and Bruce A. Leicher, and each of them singly, his true and lawful
  attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them
  singly, for him and in his name, place and stead, and in any and all capacities, to sign any and
  all amendments (including post-effective amendments) to this Registration Statement on Form S-8 of
  Altus Pharmaceuticals Inc., and to file the same, with all exhibits thereto and other documents in
  connection therewith, with the Securities and Exchange Commission, granting to the
  attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and
  every act and thing requisite or necessary to be done in or about the premises, as full to all
  intents and purposes as he might or could do in person, hereby ratifying and confirming all that
  the attorneys-in-fact and agents or any of each of them or their substitute may lawfully do or
  cause to be done by virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="14%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Signature</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Title</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Date</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ David D. Pendergast, Ph.D.
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  David D. Pendergast, Ph.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Executive Chairman and Chairman of the Board
  (principal executive officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March 11, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Jonathan I. Lieber
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Jonathan I. Lieber</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Vice President, Chief Financial Officer and
  Treasurer
  (principal financial and accounting officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March 11, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Stewart Hen
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Stewart Hen</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March 11, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Jonathan S. Leff
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Jonathan S. Leff</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March 11, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Manuel A. Navia, Ph.D.
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Manuel A. Navia, Ph.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March 11, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Harry H. Penner, Jr.
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Harry H. Penner, Jr.</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March 11, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ John P. Richard
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  John P. Richard</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March 11, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Jonathan D. Root, M.D.
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Jonathan D. Root, M.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March 11, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Michael S. Wyzga
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Michael S. Wyzga</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March 11, 2008</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "INDEX OF EXHIBITS" -->
  <DIV align="left"><A NAME="012"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX OF EXHIBITS</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="91%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" colspan="2">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" colspan="2" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">(4.1)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Restated Certificate of Incorporation of the Registrant. Filed as Exhibit&nbsp;3.1 to the Registrant&#146;s Annual Report on Form&nbsp;10-K
  for the fiscal year ended December&nbsp;31, 2006, as amended (File No.&nbsp;000-51711) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">(4.2)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Restated By-laws of the Registrant. Filed as Exhibit&nbsp;3.4 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended
  (File No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(4.3)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Common Stock Certificate. Filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended
  (File No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">(4.4)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Amended and Restated Investor Rights Agreement, dated as of May&nbsp;21, 2004. Filed as Exhibit&nbsp;4.3 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(4.5)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Common Stock Warrant to Adage Capital Partners, L.P. Filed as Exhibit&nbsp;4.5 to the Registrant&#146;s Registration Statement
  on Form&nbsp;S-3 (File No.&nbsp;333-141414) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
  
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(4.6)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Common Stock Warrant to Cystic Fibrosis Foundation Therapeutics, Inc. Filed as Exhibit&nbsp;4.9 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
  
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(4.7)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Common Stock Warrant to Cowen and Company, LLC. Filed as Exhibit&nbsp;4.11 to the Registrant&#146;s Registration Statement on
  Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
  
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(4.8)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Series&nbsp;B Preferred Stock Warrant, as amended, together with a schedule of warrant holders. Filed as Exhibit&nbsp;4.12 to
  the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
  
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(4.9)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Series&nbsp;C Preferred Stock Warrant, together with a schedule of warrant holders. Filed as Exhibit&nbsp;4.13 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
  
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(5)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares being registered. Filed herewith.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
  
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(23.1)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of counsel filed as Exhibit&nbsp;5).</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
  
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(23.2)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Deloitte &#038; Touche LLP. Filed herewith.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
  
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="left" valign="top">(24)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Power of Attorney to file future amendments (set forth on the signature page of this Registration Statement).</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
  
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
  
      <TD align="right" valign="top">(99.1)</TD>
      <TD nowrap valign="top"></TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended. Filed as
  Exhibit&nbsp;10.4 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 2006, as amended (File
  No.&nbsp;000-51711) and incorporated herein by reference.</DIV></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on
  March 11, 2008
  REGISTRATION NO. 333 -
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  under the
  SECURITIES ACT OF 1933
  ALTUS PHARMACEUTICALS INC.
  (
  Exact Name of Registrant as Specified in Its Charter)
  Delaware
  (
  State or Other Jurisdiction
  of Incorporation or Organization
  )
  04-3573277
  (
  I.R.S. Employer
  Identification No.
  )
  640 Memorial Drive
  Cambridge, MA 02139
  (
  Address, Including Zip Code, of Principal Executive Offices
  )
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended
  (Full Title of the Plan)
  David D. Pendergast, Ph.D.
  Executive Chairman
  Altus Pharmaceuticals Inc.
  640 Memorial Drive
  Cambridge, MA 02139
  (617) 299-2900
  (
  Name, Address and Telephone Number, Including Area Code, of Agent For Service
  )
  with copies to:
  Jonathan L. Kravetz, Esq.
  Megan N. Gates, Esq.
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  One Financial Center
  Boston, Massachusetts 02111
  Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer,
  a non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in
  Rule 12b-2 of the Exchange Act. (Check one):
  Large accelerated filer
  o
  Accelerated filer
  þ
  Non-accelerated filer
  o
  Smaller reporting company
  o
  (Do not check if a smaller reporting company)
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  maximum
  maximum
  Title of
  Amount to be
  offering price
  aggregate
  Amount of
  securities to be registered
  registered
  (1)
  per share
  (2)
  offering price
  (2)
  registration fee
  Common Stock, $0.01 par value
  1,144,157
  $
  5.61
  $
  6,418,721
  $
  252.26
  (1)
  The number of shares of Common Stock stated above consists of 1,144,157 additional shares which may be sold upon the exercise of options and the issuance of stock
  awards which may hereafter be granted under the Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended (the
  "Plan"). The maximum number of shares which may be sold upon the exercise of options or issuance of stock awards granted under the Plan is subject to adjustment in
  accordance with certain anti-dilution and other provisions of the Plan. Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as amended (the
  "Securities Act"), this Registration Statement covers, in addition to the number of shares stated above, an indeterminate number of shares which may be subject to
  grant or otherwise issuable upon the operation of any such anti-dilution and other provisions.
  (2)
  This calculation is made solely for the purpose of determining the registration fee pursuant to the provisions of Rule 457(c) and (h) under the Securities Act. The
  fee is calculated on the basis of the average of the high and low sale prices per share of the Common Stock on The Nasdaq Global Market as of a date (March 6, 2008)
  within five business days prior to filing this Registration Statement.
  TABLE OF CONTENTS
  PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  Item 1.
  Plan Information
  .
  Item 2.
  Registrant Information and Employee Plan Annual Information
  .
  PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference
  .
  Item 4. Description of Securities
  .
  Item 5. Interests of Named Experts and Counsel
  .
  Item 6. Indemnification of Directors and Officers
  .
  Item 7. Exemption from Registration Claimed
  .
  Item 8. Exhibits
  .
  Item 9. Undertakings
  .
  SIGNATURES
  INDEX OF EXHIBITS
  EX-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  EX-23.2 Consent of Deloitte & Touche LLP
  Table of Contents
  EXPLANATORY NOTE
  The contents of the previously filed Registration Statements on Form S-8 (File No. 333-134421 and
  File No. 333-145243) of the Registrant are hereby incorporated by reference. The purpose of this
  Form S-8 Registration Statement is to reflect an increase of 1,144,157 shares of Common Stock
  authorized for issuance under the Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee,
  Director and Consultant Stock Plan, as amended (the "Plan").
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  Item 1.
  Plan Information
  .
  The information required by Item 1 is included in documents sent or given by the Registrant to
  participants in the Plan covered by this Registration Statement pursuant to Rule 428(b)(1) under
  the Securities Act.
  Item 2.
  Registrant Information and Employee Plan Annual Information
  .
  The written statement required by Item 2 is included in documents sent or given by the
  Registrant to participants in the Plan covered by this Registration Statement pursuant to Rule
  428(b)(1) under the Securities Act.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference
  .
  The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  (1)
  The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2007
  filed on March 11, 2008 (File No. 000-51711);
  (2)
  The Registrant's Current Report on Form 8-K filed on January 30, 2008 (File No. 000-51711);
  (3)
  The Registrant's Current Report on Form 8-K filed on February 7, 2008 (File No. 000-51711);
  (4)
  The Registrant's Current Report on Form 8-K filed on February 28, 2008 (File No. 000-51711);
  (5)
  The Registrant's Current Report on Form 8-K filed on March 11, 2008 (File No. 000-51711); and
  (6)
  The description of the Registrant's Common Stock contained in the Registrant's Registration
  Statement on Form 8-A, filed with the Commission on January 11, 2006 (File No. 000-51711),
  including any amendment or report filed for the purpose of updating such description.
  All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, prior to the filing of
  a post-effective amendment which indicates that all securities offered hereby have been sold or
  which deregisters all securities then remaining unsold, shall be deemed to be incorporated by
  reference herein and to be part hereof from the date of filing of such reports and documents. Any
  statement contained in a document incorporated or deemed to be incorporated by reference herein
  shall be deemed to be modified or superseded for the purposes of this Registration Statement to the
  extent that a statement contained herein or in any other subsequently filed document which also is
  or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any
  statement so modified or superseded shall not be deemed, except as so modified or superseded, to
  constitute a part of this Registration Statement.
  Item 4. Description of Securities
  .
  Not applicable.
  Table of Contents
  Item 5. Interests of Named Experts and Counsel
  .
  The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm, their families
  and trusts for their benefit own an aggregate of approximately 12,794 shares of Common Stock of the
  Registrant and options and warrants to purchase 1,000 shares of Common Stock of the Registrant.
  Item 6. Indemnification of Directors and Officers
  .
  Incorporated herein by reference from Part II, Item 15 "Indemnification of Directors and
  Officers" of the Registrant's Registration Statement on Form S-3 (File No. 333-141414).
  Item 7. Exemption from Registration Claimed
  .
  Not applicable.
  Item 8. Exhibits
  .
  (4.1)
  Restated Certificate of Incorporation of the Registrant. Filed as Exhibit 3.1 to the Registrant's Annual Report on Form 10-K for the fiscal
  year ended December 31, 2006, as amended (File No. 000-51711) and incorporated herein by reference.
  (4.2)
  Restated By-laws of the Registrant. Filed as Exhibit 3.4 to the Registrant's Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.
  (4.3)
  Form of Common Stock Certificate. Filed as Exhibit 4.1 to the Registrant's Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.
  (4.4)
  Amended and Restated Investor Rights Agreement, dated as of May 21, 2004. Filed as Exhibit 4.3 to the Registrant's Registration Statement on
  Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.5)
  Form of Common Stock Warrant to Adage Capital Partners, L.P. Filed as Exhibit 4.5 to the Registrant's Registration Statement on Form S-3
  (File No. 333-141414) and incorporated herein by reference.
  (4.6)
  Form of Common Stock Warrant to Cystic Fibrosis Foundation Therapeutics, Inc. Filed as Exhibit 4.9 to the Registrant's
  Registration Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.7)
  Form of Common Stock Warrant to Cowen and Company, LLC. Filed as Exhibit 4.11 to the Registrant's Registration Statement on
  Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.8)
  Form of Series B Preferred Stock Warrant, as amended, together with a schedule of warrant holders. Filed as Exhibit 4.12 to
  the Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.9)
  Form of Series C Preferred Stock Warrant, together with a schedule of warrant holders. Filed as Exhibit 4.13 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares being registered. Filed herewith.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of counsel filed as Exhibit 5).
  (23.2)
  Consent of Deloitte & Touche LLP. Filed herewith.
  (24)
  Power of Attorney to file future amendments (set forth on the signature page of this Registration Statement).
  (99.1)
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended. Filed as
  Table of Contents
  Exhibit 10.4 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2006, as amended (File
  No. 000-51711) and incorporated herein by reference.
  Item 9. Undertakings
  .
  (a)
  The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made, a post-effective
  amendment to this Registration Statement:
  (i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
  (ii) To reflect in the prospectus any facts or events arising after the effective date of
  the Registration Statement (or the most recent post-effective amendment thereof) which,
  individually or in the aggregate, represent a fundamental change in the information set forth
  in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in
  volume of securities offered (if the total dollar value of securities offered would not exceed
  that which was registered) and any deviation from the low or high end of the estimated maximum
  offering range may be reflected in the form of prospectus filed with the Commission pursuant to
  Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20%
  change in the maximum aggregate offering price set forth in the "Calculation of Registration
  Fee" table in the effective Registration Statement.
  (iii) To include any material information with respect to the plan of distribution not
  previously disclosed in the Registration Statement or any material change to such information
  in the Registration Statement;
  Provided, however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information
  required to be included in a post-effective amendment by those paragraphs is contained in reports
  filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section
  15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in this
  Registration Statement.
  (2) That, for the purpose of determining any liability under the Securities Act of 1933, each
  such post-effective amendment shall be deemed to be a new registration statement relating to the
  securities offered therein, and the offering of such securities at that time shall be deemed to
  be the initial bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act of 1933, each
  filing of the Registrant's annual report pursuant to Section 13(a) or
  Section 15(d) of the Securities Exchange Act of 1934 that is
  incorporated by reference in this Registration Statement shall be
  deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (c)
  Insofar as indemnification for liabilities arising under the
  Securities Act of 1933 may be permitted to directors, officers and
  controlling persons of the Registrant pursuant to the foregoing
  provisions, or otherwise, the Registrant has been advised that in the
  opinion of the Securities and Exchange Commission such indemnification
  is against public policy as expressed in the Act and is, therefore,
  unenforceable. In the event that a claim for indemnification against
  such liabilities (other than the payment by the Registrant of expenses
  incurred or paid by a director, officer or controlling person of the
  Registrant in the successful defense of any action, suit or
  proceeding) is asserted by such director, officer or controlling
  person in connection with the securities being registered, the
  Registrant will, unless in the opinion of its counsel the matter has
  been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by
  it is against public policy as expressed in the Act and will be
  governed by the final adjudication of such issue.
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Cambridge, Massachusetts on March 11, 2008.
  ALTUS PHARMACEUTICALS INC.
  By:
  /s/ David D. Pendergast, Ph.D.
  David D. Pendergast, Ph.D.
  Executive Chairman
  POWER OF ATTORNEY
  Each person whose signature appears below constitutes and appoints David D. Pendergast,
  Jonathan I. Lieber and Bruce A. Leicher, and each of them singly, his true and lawful
  attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them
  singly, for him and in his name, place and stead, and in any and all capacities, to sign any and
  all amendments (including post-effective amendments) to this Registration Statement on Form S-8 of
  Altus Pharmaceuticals Inc., and to file the same, with all exhibits thereto and other documents in
  connection therewith, with the Securities and Exchange Commission, granting to the
  attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and
  every act and thing requisite or necessary to be done in or about the premises, as full to all
  intents and purposes as he might or could do in person, hereby ratifying and confirming all that
  the attorneys-in-fact and agents or any of each of them or their substitute may lawfully do or
  cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ David D. Pendergast, Ph.D.
  David D. Pendergast, Ph.D.
  Executive Chairman and Chairman of the Board
  (principal executive officer)
  March 11, 2008
  /s/ Jonathan I. Lieber
  Jonathan I. Lieber
  Vice President, Chief Financial Officer and
  Treasurer
  (principal financial and accounting officer)
  March 11, 2008
  /s/ Stewart Hen
  Stewart Hen
  Director
  March 11, 2008
  /s/ Jonathan S. Leff
  Jonathan S. Leff
  Director
  March 11, 2008
  /s/ Manuel A. Navia, Ph.D.
  Manuel A. Navia, Ph.D.
  Director
  March 11, 2008
  /s/ Harry H. Penner, Jr.
  Harry H. Penner, Jr.
  Director
  March 11, 2008
  /s/ John P. Richard
  John P. Richard
  Director
  March 11, 2008
  /s/ Jonathan D. Root, M.D.
  Jonathan D. Root, M.D.
  Director
  March 11, 2008
  /s/ Michael S. Wyzga
  Michael S. Wyzga
  Director
  March 11, 2008
  Table of Contents
  INDEX OF EXHIBITS
  Exhibit
  Number
  Description
  (4.1)
  Restated Certificate of Incorporation of the Registrant. Filed as Exhibit 3.1 to the Registrant's Annual Report on Form 10-K
  for the fiscal year ended December 31, 2006, as amended (File No. 000-51711) and incorporated herein by reference.
  (4.2)
  Restated By-laws of the Registrant. Filed as Exhibit 3.4 to the Registrant's Registration Statement on Form S-1, as amended
  (File No. 333-129037) and incorporated herein by reference.
  (4.3)
  Form of Common Stock Certificate. Filed as Exhibit 4.1 to the Registrant's Registration Statement on Form S-1, as amended
  (File No. 333-129037) and incorporated herein by reference.
  (4.4)
  Amended and Restated Investor Rights Agreement, dated as of May 21, 2004. Filed as Exhibit 4.3 to the Registrant's
  Registration Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.5)
  Form of Common Stock Warrant to Adage Capital Partners, L.P. Filed as Exhibit 4.5 to the Registrant's Registration Statement
  on Form S-3 (File No. 333-141414) and incorporated herein by reference.
  (4.6)
  Form of Common Stock Warrant to Cystic Fibrosis Foundation Therapeutics, Inc. Filed as Exhibit 4.9 to the Registrant's
  Registration Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.7)
  Form of Common Stock Warrant to Cowen and Company, LLC. Filed as Exhibit 4.11 to the Registrant's Registration Statement on
  Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.8)
  Form of Series B Preferred Stock Warrant, as amended, together with a schedule of warrant holders. Filed as Exhibit 4.12 to
  the Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.9)
  Form of Series C Preferred Stock Warrant, together with a schedule of warrant holders. Filed as Exhibit 4.13 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares being registered. Filed herewith.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of counsel filed as Exhibit 5).
  (23.2)
  Consent of Deloitte & Touche LLP. Filed herewith.
  (24)
  Power of Attorney to file future amendments (set forth on the signature page of this Registration Statement).
  (99.1)
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended. Filed as
  Exhibit 10.4 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2006, as amended (File
  No. 000-51711) and incorporated herein by reference.