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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <P align="left" style="font-size: 10pt">As filed with the Securities and Exchange Commission on April&nbsp;9, 2004
  
  
  
  <div align="center" style="font-size: 10pt"><HR size="1" noshade width="100%" align="center"></div>
  
  
  <P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, DC 20549</B>
  </DIV>
  
  <P align="center" style="font-size: 18pt"><B>FORM S-8</B>
  
  <DIV align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENT<br>
  UNDER THE<br>
  SECURITIES ACT OF 1933</B></DIV>
  
  
  <P align="center" style="font-size: 24pt"><B>BIOPURE CORPORATION</B>
  
  <DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
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      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-2836871</B></TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top">(State or other jurisdiction of incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
  </TR>
  
  
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  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt"><B>11 Hurley Street<BR>
  Cambridge, Massachusetts 02141</B><BR>
  (Address of principal executive offices) (zip code)
  
  
  
  <P align="center" style="font-size: 10pt"><B>2002 OMNIBUS SECURITIES AND INCENTIVE PLAN, AS AMENDED</B><BR>
  (Full title of the plan)
  
  
  
  <P align="center" style="font-size: 10pt"><B>JANE KOBER<BR>
  SENIOR VICE PRESIDENT<BR>
  Biopure Corporation<BR>
  11 Hurley Street<BR>
  Cambridge, Massachusetts</B><BR>
  (Name and address of agent for service)
  
  
  
  <P align="center" style="font-size: 10pt"><B>(617)&nbsp;234-6500</B><BR>
  (Telephone number, including area code, of agent for service)
  
  
  
  <P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
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      <TD width="1%">&nbsp;</TD>
      <TD width="13%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Title of securities</B></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>to be</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount to be</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>offering price per</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>aggregate offering</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>registered</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>registered (1)</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>share (2)</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>price (2)</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Registration Fee</B><HR size="1" noshade></TD>
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      <TD><DIV style="margin-left:10px; text-indent:-10px">Class&nbsp;A Common
  Stock (3)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" align="center">4,000,000 shares</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">1.56</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">6,220,000</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">788.07</TD>
      <TD>&nbsp;</TD>
  </TR>
  
  
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  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="right">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>In addition, pursuant to Rule 416(a) under the Securities Act of 1933,
  this registration statement also covers any additional securities to be
  offered or issued in connection with a stock split, stock dividend or
  similar transaction.</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
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      <TD width="1%" nowrap align="right">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>This calculation is made solely for the purpose of determining the
  registration fee pursuant to the provisions of Rule 457(h) under the
  Securities Act of 1933 as follows: the fee for the shares available for
  options not yet granted is calculated pursuant to Rule 457(c) under the
  Securities Act on the basis of the average of the high and low sale prices
  per share of the common stock on The Nasdaq Stock Market on April&nbsp;6, 2004.</TD>
  </TR>
  
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  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="right">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Including the associated preferred stock purchase rights.</TD>
  </TR>
  
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  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
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  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE:</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">ITEM 8. EXHIBITS.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#005">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#006">INDEX TO EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b50185biexv5.txt">EX-5 OPINION OF JANE KOBER</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b50185biexv23w2.txt">EX-23.2 CONSENT OF ERNST & YOUNG LLP</A></TD></TR>
  </TABLE>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  
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  <P align="center" style="font-size: 10pt">PART II
  
  
  
  <P align="center" style="font-size: 10pt">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  
  
  <!-- link2 "ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE:" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="left" style="font-size: 10pt">ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE:
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by Biopure with the Commission are
  incorporated herein by reference.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Annual Report on Form 10-K/A for the year ended October&nbsp;31, 2003.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Quarterly Report on Form 10-Q for the quarter ended January&nbsp;31, 2004.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Reports on Form 8-K filed April&nbsp;7, 2004, February&nbsp;20, 2004 and
  December&nbsp;11, 2003.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;The description of the class A common stock contained in Biopure&#146;s
  Registration Statement on Form S-1 (Registration No.&nbsp;333-78829), that was
  incorporated by reference into our registration statement on Form 8-A/A filed
  on July&nbsp;26, 1999.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;The description of the preferred stock purchase rights contained in
  our registration statement on Form 8-A filed on November&nbsp;4, 1999.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by Biopure after the date hereof pursuant to Sections
  13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934 prior to the
  filing of a post-effective amendment which indicates that all securities
  offered hereby have been sold or which deregisters all securities then
  remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such documents.
  
  <!-- link2 "ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="left" style="font-size: 10pt">ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As of April&nbsp;6, 2004, Jane Kober, Esq., Senior Vice President, General
  Counsel and Secretary of the Company, held 3,290 shares of common stock and
  options to purchase 213,413 shares of common stock.
  
  <!-- link2 "ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="left" style="font-size: 10pt">ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Our Restated Certificate of Incorporation provides that each of our
  directors and officers shall be indemnified and held harmless by us, to the
  fullest extent authorized by the Delaware General Corporation Law, against all
  expense, liability and loss (including attorneys&#146; fees, judgments, fines,
  ERISA, excise taxes or penalties, and amounts paid in settlement) reasonably
  incurred by reason of the fact that he or she is a director or officer.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Delaware General Corporation Law authorizes a corporation to indemnify
  its directors and officers provided that the corporation shall not eliminate or
  limit the liability of a director as follows:
  
  
  <P>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">&#149;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>for any action brought by or in the right of a
  corporation where the director or</TD>
  </TR>
  
  </TABLE>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt"><TR valign="top" style="font-size: 10pt; color: #textcolor#; background: #bgcolor#">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>officer is adjudged to be liable to the corporation, except where
  a court determines the director or officer is entitled to
  indemnity;</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">&#149;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>for acts or omissions not in good faith or that involve
  conduct that the director or officer believes is not in the best
  interests of the corporation;</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">&#149;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>for knowing violations of the law;</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">&#149;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>for any transaction from which the directors derived an
  improper personal benefit; and</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">&#149;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>for payment of dividends or approval of stock
  repurchases or redemptions leading to liability under Section&nbsp;174
  of the Delaware General Corporation Law.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Delaware General Corporation Law requires a corporation to indemnify a
  director or officer to the extent that the director or officer has been
  successful, on the merits or otherwise, in defense of any action, suit or
  proceeding for which indemnification is lawful.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Our Restated Certificate of Incorporation also provides directors and
  officers with the right to be paid by us for expenses (including attorneys&#146;
  fees) incurred in defending any proceeding in advance of the proceeding&#146;s final
  disposition. If a claim is not promptly paid in full by us, as further
  described in the Restated Certificate of Incorporation, the director or officer
  who is entitled to indemnification may bring suit against us to recover the
  unpaid amount of the claim. These rights of indemnification and advancement of
  expenses conferred in our Restated Certificate of Incorporation are not
  exclusive of any other right which may be acquired.
  
  <!-- link2 "ITEM 8. EXHIBITS." -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <P align="left" style="font-size: 10pt">ITEM 8. EXHIBITS.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="75%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="9%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="86%">&nbsp;</TD>
  </TR>
  
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  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation*</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By-laws**</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Jane Kober, Esq., as to the legality of shares being registered.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Jane Kober (included in opinion of counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney to file future amendments (set forth on the
  signature page of this Registration Statement).</TD>
  </TR>
  
  
  <!-- End Table Body -->
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  </DIV>
  
  
  
  
  <P>
  
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  <TR valign="top">
      <TD width="98%">*Previously filed as an exhibit to Registration Statement No.&nbsp;333-30382 and
  incorporated herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="98%">**Previously filed as an exhibit to Registration Statement No.&nbsp;333-78829 and
  incorporated herein by reference.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  <P align="left" style="font-size: 10pt"><B>ITEM 9. UNDERTAKINGS.</B>
  
  
  <P>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes:</TD>
  </TR>
  
  </TABLE>
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">(1)&nbsp;To file, during any period in which offers or sales are being
  made, a post-effective amendment to this Registration Statement:
  
  
  
  <P align="left" style="margin-left:8%; font-size: 10pt">(i)&nbsp;To include any prospectus required by Section&nbsp;10(a)(3) of
  the Securities Act of 1933;
  
  
  
  <P align="left" style="margin-left:8%; font-size: 10pt">(ii)&nbsp;To reflect in the prospectus any facts or events arising
  after the effective date of the Registration Statement (or the
  most recent post-effective amendment thereof) which,
  individually or in the aggregate, represent a fundamental change
  in the information set forth in the Registration Statement.
  Notwithstanding the foregoing, any increase or decrease in
  volume of securities offered (if the total dollar value of
  securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated
  maximum offering range may be reflected in the form of
  prospectus filed with the Commission pursuant to Rule 424(b) if,
  in the aggregate, the changes in volume and price represent no
  more than a 20% change in the maximum aggregate offering price
  set forth in the &#147;Calculation of Registration Fee&#148; table in the
  effective Registration Statement.
  
  
  
  <P align="left" style="margin-left:8%; font-size: 10pt">(iii)&nbsp;To include any material information with respect to the
  plan of distribution not previously disclosed in the
  Registration Statement or any material change to such
  information in the Registration Statement.
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
  apply if the Registration Statement is on Form S-3, Form S-8 or
  Form F-3, and the information required to be included in a
  post-effective amendment by those paragraphs is contained in
  periodic reports filed with or furnished to the Commission by the
  Registrant pursuant to Section&nbsp;13 or Section 15(d) of the
  Securities Exchange Act of 1934 that are incorporated by reference
  in this Registration Statement.
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">(2)&nbsp;That, for the purpose of determining any liability under the
  Securities Act of 1933, each such post-effective amendment shall be
  deemed to be a new registration statement relating to the
  securities offered therein, and the offering of such securities at
  that time shall be deemed to be the initial bona fide offering
  thereof.
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">(3)&nbsp;To remove from registration by means of a post-effective
  amendment any of the securities being registered which remain
  unsold at the termination of the offering.
  
  
  <P>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes that, for
  purposes of determining any liability under the Securities Act of
  1933, each filing of the Registrant&#146;s annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities</TD>
  </TR>
  
  </TABLE>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt"><TR valign="top" style="font-size: 10pt; color: #textcolor#; background: #bgcolor#">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Exchange Act of 1934 that is incorporated by reference in this
  Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the
  offering of such securities at that time shall be deemed to be the
  initial bona fide offering thereof.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar as indemnification for liabilities arising under the Securities
  Act of 1933 may be permitted to directors, officers and controlling persons of
  the Registrant pursuant to the foregoing provisions, or otherwise, the
  Registrant has been advised that in the opinion of the Securities and Exchange
  Commission such indemnification is against public policy as expressed in the
  Act and is, therefore, unenforceable. In the event that a claim for
  indemnification against such liabilities (other than the payment by the
  Registrant of expenses incurred or paid by a director, officer or controlling
  person of the Registrant in the successful defense of any action, suit or
  proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the Registrant will, unless in
  the opinion of its counsel the matter has been settled by controlling
  precedent, submit to a court of appropriate jurisdiction the question whether
  such indemnification by it is against public policy as expressed in the Act and
  will be governed by the final adjudication of such issue.
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <P align="center" style="font-size: 10pt">SIGNATURES
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, the registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned thereunto duly
  authorized, in Cambridge, Massachusetts, on the 7th day of April, 2004.
  
  
  <P align="center" style="font-size: 10pt">BIOPURE CORPORATION
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="48%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="46%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By:
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">/s/ Ronald F. Richards</TD>
  </TR>
  
  <TR style="font-size: 1px">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><HR size="1" noshade>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" valign="top" align="left">Ronald F. Richards<br></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" valign="top" align="left">CHIEF FINANCIAL OFFICER<br></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" valign="top" align="left">&nbsp;(Principal financial and accounting officer)</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">POWER OF ATTORNEY
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
  appears below constitutes and appoints FRANCIS H. MURPHY, RONALD F. RICHARDS
  and JANE KOBER, and each of them, as his or her true and lawful
  attorneys-in-fact and agents, with full power of substitution and
  resubstitution, for the undersigned and in his or her name, place and stead, in
  any and all capacities, to sign any or all amendments (including post-effective
  amendments) to the Registration Statement and to file the same, with all
  exhibits thereto, and all documents in connection therewith, with the
  Securities and Exchange Commission, granting unto said attorneys-in-fact and
  agents, and each of them, full power of authority to do and perform each and
  every act and thing requisite and necessary to be done in connection therewith,
  as fully to all intents and purposes as he or she might or could do in person,
  hereby ratifying and confirming all that said attorneys-in-fact and agents,
  each acting alone, or his or her substitute or substitutes, may lawfully do or
  cause to be done by virtue hereof.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, this Registration
  Statement has been signed below by the following persons in the capacities
  indicated and on the dates indicated.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="65%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="45%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>SIGNATURES</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>TITLE</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>DATE</B></TD>
  </TR>
  
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Charles A. Sanders, M.D.
  <HR size="1" noshade>
  Charles A. Sanders, M.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director and
  Chairman of the
  Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">April&nbsp;7, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Francis H. Murphy
  <HR size="1" noshade>
  Francis H. Murphy
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Interim Chief<BR>
  Executive Officer<BR>
  (Principal executive<BR>
  officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">April 7, 2004</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="65%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="45%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>SIGNATURES</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>TITLE</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>DATE</B></TD>
  </TR>
  
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Ronald F. Richards
  <HR size="1" noshade>
  Ronald F. Richards
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Chief Financial
  Officer (Principal
  financial and
  accounting officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">April 7, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ David N. Judelson
  <HR size="1" noshade>
  David N. Judelson
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director and Vice
  Chairman of the
  Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">April 7, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Carl W. Rausch
  <HR size="1" noshade>
  Carl W. Rausch
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director, Vice
  Chairman of the
  Board and Chief
  Technology Officer
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">April 7, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Daniel P. Harrington
  <HR size="1" noshade>
  Daniel P. Harrington
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">April 7, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ C. Everett Koop, M.D.
  <HR size="1" noshade>
  C. Everett Koop, M.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">April 7, 2004</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "INDEX TO EXHIBITS" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <P align="center" style="font-size: 10pt">INDEX TO EXHIBITS
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="65%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="11%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="84%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Number</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Description of Exhibit</B><HR size="1" noshade></TD>
  </TR>
  
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation*</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By-laws**</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Jane Kober</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Jane Kober (contained in Exhibit&nbsp;5)</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (set forth on the signature page of this
  Registration Statement).</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  <P>
  
  <HR size="1" width="18%" align="left" noshade>
  
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top">
      <TD width="96%">*Previously filed as an exhibit to Registration Statement No.&nbsp;333-30382 and
  incorporated herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="96%">**Previously filed as an exhibit to Registration Statement No.&nbsp;333-78829 and
  incorporated herein by reference.</TD>
  </TR>
  
  </TABLE>
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  
  </BODY>
  </HTML>
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metadata_filer: {"company-data": {"conformed-name": "BIOPURE CORP", "cik": "0000815508", "assigned-sic": "2836", "irs-number": "042836871", "state-of-incorporation": "DE", "fiscal-year-end": "1031"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-114381", "film-number": "04727334"}, "business-address": {"street1": "11 HURLEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02141", "phone": "6172346500"}, "mail-address": {"street1": "11 HURLEY STREET", "city": "CAMBRIDGE", "state": "MA", "zip": "02141"}}
text: BIOPURE CORPORATION
  Table of Contents
  As filed with the Securities and Exchange Commission on April 9, 2004
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, DC 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER THE
  SECURITIES ACT OF 1933
  BIOPURE CORPORATION
  (Exact name of registrant as specified in its charter)
  Delaware
  04-2836871
  (State or other jurisdiction of incorporation or organization)
  (I.R.S. Employer Identification No.)
  11 Hurley Street
  Cambridge, Massachusetts 02141
  (Address of principal executive offices) (zip code)
  2002 OMNIBUS SECURITIES AND INCENTIVE PLAN, AS AMENDED
  (Full title of the plan)
  JANE KOBER
  SENIOR VICE PRESIDENT
  Biopure Corporation
  11 Hurley Street
  Cambridge, Massachusetts
  (Name and address of agent for service)
  (617) 234-6500
  (Telephone number, including area code, of agent for service)
  CALCULATION OF REGISTRATION FEE
  Title of securities
  Proposed maximum
  Proposed maximum
  to be
  Amount to be
  offering price per
  aggregate offering
  Amount of
  registered
  registered (1)
  share (2)
  price (2)
  Registration Fee
  Class A Common
  Stock (3)
  4,000,000 shares
  $
  1.56
  $
  6,220,000
  $
  788.07
  (1)
  In addition, pursuant to Rule 416(a) under the Securities Act of 1933,
  this registration statement also covers any additional securities to be
  offered or issued in connection with a stock split, stock dividend or
  similar transaction.
  (2)
  This calculation is made solely for the purpose of determining the
  registration fee pursuant to the provisions of Rule 457(h) under the
  Securities Act of 1933 as follows: the fee for the shares available for
  options not yet granted is calculated pursuant to Rule 457(c) under the
  Securities Act on the basis of the average of the high and low sale prices
  per share of the common stock on The Nasdaq Stock Market on April 6, 2004.
  (3)
  Including the associated preferred stock purchase rights.
  TABLE OF CONTENTS
  PART II
  ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE:
  ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
  ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS
  ITEM 8. EXHIBITS.
  SIGNATURES
  INDEX TO EXHIBITS
  EX-5 OPINION OF JANE KOBER
  EX-23.2 CONSENT OF ERNST & YOUNG LLP
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE:
  The following documents filed by Biopure with the Commission are
  incorporated herein by reference.
  (a) Annual Report on Form 10-K/A for the year ended October 31, 2003.
  (b) Quarterly Report on Form 10-Q for the quarter ended January 31, 2004.
  (c) Reports on Form 8-K filed April 7, 2004, February 20, 2004 and
  December 11, 2003.
  (d) The description of the class A common stock contained in Biopure's
  Registration Statement on Form S-1 (Registration No. 333-78829), that was
  incorporated by reference into our registration statement on Form 8-A/A filed
  on July 26, 1999.
  (e) The description of the preferred stock purchase rights contained in
  our registration statement on Form 8-A filed on November 4, 1999.
  All documents filed by Biopure after the date hereof pursuant to Sections
  13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934 prior to the
  filing of a post-effective amendment which indicates that all securities
  offered hereby have been sold or which deregisters all securities then
  remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such documents.
  ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
  As of April 6, 2004, Jane Kober, Esq., Senior Vice President, General
  Counsel and Secretary of the Company, held 3,290 shares of common stock and
  options to purchase 213,413 shares of common stock.
  ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS
  Our Restated Certificate of Incorporation provides that each of our
  directors and officers shall be indemnified and held harmless by us, to the
  fullest extent authorized by the Delaware General Corporation Law, against all
  expense, liability and loss (including attorneys' fees, judgments, fines,
  ERISA, excise taxes or penalties, and amounts paid in settlement) reasonably
  incurred by reason of the fact that he or she is a director or officer.
  The Delaware General Corporation Law authorizes a corporation to indemnify
  its directors and officers provided that the corporation shall not eliminate or
  limit the liability of a director as follows:
  •
  for any action brought by or in the right of a
  corporation where the director or
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  officer is adjudged to be liable to the corporation, except where
  a court determines the director or officer is entitled to
  indemnity;
  •
  for acts or omissions not in good faith or that involve
  conduct that the director or officer believes is not in the best
  interests of the corporation;
  •
  for knowing violations of the law;
  •
  for any transaction from which the directors derived an
  improper personal benefit; and
  •
  for payment of dividends or approval of stock
  repurchases or redemptions leading to liability under Section 174
  of the Delaware General Corporation Law.
  The Delaware General Corporation Law requires a corporation to indemnify a
  director or officer to the extent that the director or officer has been
  successful, on the merits or otherwise, in defense of any action, suit or
  proceeding for which indemnification is lawful.
  Our Restated Certificate of Incorporation also provides directors and
  officers with the right to be paid by us for expenses (including attorneys'
  fees) incurred in defending any proceeding in advance of the proceeding's final
  disposition. If a claim is not promptly paid in full by us, as further
  described in the Restated Certificate of Incorporation, the director or officer
  who is entitled to indemnification may bring suit against us to recover the
  unpaid amount of the claim. These rights of indemnification and advancement of
  expenses conferred in our Restated Certificate of Incorporation are not
  exclusive of any other right which may be acquired.
  ITEM 8. EXHIBITS.
  3.1
  Restated Certificate of Incorporation*
  3.2
  By-laws**
  5
  Opinion of Jane Kober, Esq., as to the legality of shares being registered.
  23.1
  Consent of Jane Kober (included in opinion of counsel filed as Exhibit 5).
  23.2
  Consent of Ernst & Young LLP.
  24
  Power of Attorney to file future amendments (set forth on the
  signature page of this Registration Statement).
  *Previously filed as an exhibit to Registration Statement No. 333-30382 and
  incorporated herein by reference.
  **Previously filed as an exhibit to Registration Statement No. 333-78829 and
  incorporated herein by reference.
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  ITEM 9. UNDERTAKINGS.
  (a)
  The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being
  made, a post-effective amendment to this Registration Statement:
  (i) To include any prospectus required by Section 10(a)(3) of
  the Securities Act of 1933;
  (ii) To reflect in the prospectus any facts or events arising
  after the effective date of the Registration Statement (or the
  most recent post-effective amendment thereof) which,
  individually or in the aggregate, represent a fundamental change
  in the information set forth in the Registration Statement.
  Notwithstanding the foregoing, any increase or decrease in
  volume of securities offered (if the total dollar value of
  securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated
  maximum offering range may be reflected in the form of
  prospectus filed with the Commission pursuant to Rule 424(b) if,
  in the aggregate, the changes in volume and price represent no
  more than a 20% change in the maximum aggregate offering price
  set forth in the "Calculation of Registration Fee" table in the
  effective Registration Statement.
  (iii) To include any material information with respect to the
  plan of distribution not previously disclosed in the
  Registration Statement or any material change to such
  information in the Registration Statement.
  Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
  apply if the Registration Statement is on Form S-3, Form S-8 or
  Form F-3, and the information required to be included in a
  post-effective amendment by those paragraphs is contained in
  periodic reports filed with or furnished to the Commission by the
  Registrant pursuant to Section 13 or Section 15(d) of the
  Securities Exchange Act of 1934 that are incorporated by reference
  in this Registration Statement.
  (2) That, for the purpose of determining any liability under the
  Securities Act of 1933, each such post-effective amendment shall be
  deemed to be a new registration statement relating to the
  securities offered therein, and the offering of such securities at
  that time shall be deemed to be the initial bona fide offering
  thereof.
  (3) To remove from registration by means of a post-effective
  amendment any of the securities being registered which remain
  unsold at the termination of the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for
  purposes of determining any liability under the Securities Act of
  1933, each filing of the Registrant's annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities
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  Exchange Act of 1934 that is incorporated by reference in this
  Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the
  offering of such securities at that time shall be deemed to be the
  initial bona fide offering thereof.
  Insofar as indemnification for liabilities arising under the Securities
  Act of 1933 may be permitted to directors, officers and controlling persons of
  the Registrant pursuant to the foregoing provisions, or otherwise, the
  Registrant has been advised that in the opinion of the Securities and Exchange
  Commission such indemnification is against public policy as expressed in the
  Act and is, therefore, unenforceable. In the event that a claim for
  indemnification against such liabilities (other than the payment by the
  Registrant of expenses incurred or paid by a director, officer or controlling
  person of the Registrant in the successful defense of any action, suit or
  proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the Registrant will, unless in
  the opinion of its counsel the matter has been settled by controlling
  precedent, submit to a court of appropriate jurisdiction the question whether
  such indemnification by it is against public policy as expressed in the Act and
  will be governed by the final adjudication of such issue.
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  SIGNATURES
  Pursuant to the requirements of the Securities Act, the registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned thereunto duly
  authorized, in Cambridge, Massachusetts, on the 7th day of April, 2004.
  BIOPURE CORPORATION
  By:
  /s/ Ronald F. Richards
  Ronald F. Richards
  CHIEF FINANCIAL OFFICER
  (Principal financial and accounting officer)
  POWER OF ATTORNEY
  KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
  appears below constitutes and appoints FRANCIS H. MURPHY, RONALD F. RICHARDS
  and JANE KOBER, and each of them, as his or her true and lawful
  attorneys-in-fact and agents, with full power of substitution and
  resubstitution, for the undersigned and in his or her name, place and stead, in
  any and all capacities, to sign any or all amendments (including post-effective
  amendments) to the Registration Statement and to file the same, with all
  exhibits thereto, and all documents in connection therewith, with the
  Securities and Exchange Commission, granting unto said attorneys-in-fact and
  agents, and each of them, full power of authority to do and perform each and
  every act and thing requisite and necessary to be done in connection therewith,
  as fully to all intents and purposes as he or she might or could do in person,
  hereby ratifying and confirming all that said attorneys-in-fact and agents,
  each acting alone, or his or her substitute or substitutes, may lawfully do or
  cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act, this Registration
  Statement has been signed below by the following persons in the capacities
  indicated and on the dates indicated.
  SIGNATURES
  TITLE
  DATE
  /s/ Charles A. Sanders, M.D.
  Charles A. Sanders, M.D.
  Director and
  Chairman of the
  Board
  April 7, 2004
  /s/ Francis H. Murphy
  Francis H. Murphy
  Interim Chief
  Executive Officer
  (Principal executive
  officer)
  April 7, 2004
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  SIGNATURES
  TITLE
  DATE
  /s/ Ronald F. Richards
  Ronald F. Richards
  Chief Financial
  Officer (Principal
  financial and
  accounting officer)
  April 7, 2004
  /s/ David N. Judelson
  David N. Judelson
  Director and Vice
  Chairman of the
  Board
  April 7, 2004
  /s/ Carl W. Rausch
  Carl W. Rausch
  Director, Vice
  Chairman of the
  Board and Chief
  Technology Officer
  April 7, 2004
  /s/ Daniel P. Harrington
  Daniel P. Harrington
  Director
  April 7, 2004
  /s/ C. Everett Koop, M.D.
  C. Everett Koop, M.D.
  Director
  April 7, 2004
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  INDEX TO EXHIBITS
  Number
  Description of Exhibit
  3.1
  Restated Certificate of Incorporation*
  3.2
  By-laws**
  5
  Opinion of Jane Kober
  23.1
  Consent of Jane Kober (contained in Exhibit 5)
  23.2
  Consent of Ernst & Young LLP
  24
  Power of Attorney (set forth on the signature page of this
  Registration Statement).
  *Previously filed as an exhibit to Registration Statement No. 333-30382 and
  incorporated herein by reference.
  **Previously filed as an exhibit to Registration Statement No. 333-78829 and
  incorporated herein by reference.