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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 18pt">As filed with the Securities and Exchange Commission on September&nbsp;22, 2006
  </DIV>
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 0pt">Registration No.&nbsp;333-_________<br>&nbsp;
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><b>REGISTRATION STATEMENT UNDER<BR>
  THE SECURITIES ACT OF 1933</b></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>Alkermes, Inc.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact Name of Registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="48%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="48%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Pennsylvania</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>23-2472830</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or other jurisdiction of incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>ALKERMES, INC.<BR>
  88 SIDNEY STREET<BR>
  CAMBRIDGE, MASSACHUSETTS 02139-4234<BR>
  TELEPHONE: (617)&nbsp;494-0171</B><BR>
  (Address, including zip code, and telephone number, including area code,<BR>
  of registrant&#146;s principal executive offices)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>ALKERMES, INC. 2002 RESTRICTED STOCK AWARD PLAN</B><BR>
  (Full title of the plan)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">Richard F. Pops<BR>
  Chief Executive Officer<BR>
  ALKERMES, INC.<BR>
  88 Sidney Street<BR>
  Cambridge, Massachusetts 02139-4234<BR>
  Telephone: (617)&nbsp;494-0171<BR>
  (Name, address, including zip code, and telephone number, including area code,<BR>
  of agent for service)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">Copies to:</DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="48%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="50%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Mitchell S. Bloom, Esq.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Kathryn L. Biberstein, Esq.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Robert E. Puopolo
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Alkermes, Inc.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Goodwin Procter LLP
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">88 Sidney Street</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">53 State Street
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Cambridge, MA 02139</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Boston, MA 02109
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Telephone: (617)&nbsp;583-6255</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Telephone: (617)&nbsp;570-1055</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>CALCULATION OF REGISTRATION FEE</B></DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Offering Price Per</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Aggregate Offering</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="left">Title of Securities</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Registered (1)(3)</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Share</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Registration Fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">300,000</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">14.69</TD>
      <TD nowrap style="border-top: 2px solid #000000">(2)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">4,407,000</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">471.55</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Totals:</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">300,000</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">4,407,000</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">471.55</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt; margin-top: 6pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Pursuant to Rule&nbsp;416 under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend, recapitalization, and certain other
  capital adjustments and the like.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of calculating the registration fee.
  In accordance with Rules 457(c) and 457(h), the proposed maximum
  offering price per share, the proposed maximum aggregate offering
  price, and the registration fee shown has been computed based upon the
  average of the high and low sales price of the Company&#146;s Common Stock
  on September&nbsp;15, 2006, $14.69, as reported on the Nasdaq Global Market
  with respect to securities for which options have not been granted.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>This registration statement relates 300,000 shares of Common Stock,
  $.01 par value per share, reserved for issuance under the 2002
  Restricted Stock Award Plan (the &#147;2002 Plan&#148;), which shares are in
  addition to 500,000 shares of Common Stock, $0.01 par value per share,
  previously registered pursuant to Registration Statements on Form S-8
  (Registration Nos. 333-107208) and filed with the Securities and
  Exchange Commission. The current filing is being made to register the
  300,000 shares which are issuable under the 2002 Plan.</TD>
  </TR>
  
  </TABLE>
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART I</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#001">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;3. <U>Incorporation of Documents by Reference</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;4. <U>Description of Securities</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;5. <U>Interests of Named Experts and Counsel</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;8. <U>Exhibits</U>.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#006">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#007">POWER OF ATTORNEY AND SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#008">INDEX TO EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b62447a1exv5w1.htm">Ex-5.1 Opinion of Ballard Spahr Andrews & Ingersoll</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b62447a1exv23w2.htm">Ex-23.2 Consent of Deloitte & Touche LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <!-- link1 "PART I" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Part&nbsp;I and Items 6, 7 and 9 of Part&nbsp;II of Alkermes, Inc.&#146;s Registration Statement on Form S-8
  (File No.&nbsp;333-89573) are incorporated by reference herein pursuant to Instruction E of Form S-8.
  </DIV>
  
  <!-- link1 "PART II" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  </DIV>
  
  <!-- link2 "Item&nbsp;3. <U>Incorporation of Documents by Reference</U>." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;3. <U>Incorporation of Documents by Reference</U>.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">The following documents filed with the Securities and Exchange Commission (the &#147;Commission&#148;)
  pursuant to the Securities Exchange Act of 1934 (the &#147;Exchange Act&#148;) by Alkermes, Inc. (the
  &#147;Company&#148;) (File No.&nbsp;1-14131) or pursuant to the Securities Act of 1933, as amended (the
  &#147;Securities Act&#148;) are incorporated herein by reference:
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Annual Report on Form 10-K for the fiscal year ended March&nbsp;31, 2006
  filed on June&nbsp;14, 2006 and as amended by an Amendment No.&nbsp;1 to Annual
  Report on Form 10-K/A for the fiscal year ended March&nbsp;31, 2006 filed
  on August&nbsp;14, 2006;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Quarterly Report on Form 10-Q for the period ended June&nbsp;30, 2006;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>All other documents filed by the Company pursuant to 13(a) or 15(d) of
  the Exchange Act since the end of the fiscal year covered by the
  document referred to in (a)&nbsp;above; and</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(d)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Item&nbsp;1 of Registration Statement of the Company on Form 8-A dated June
  28, 1991, as amended by a Registration Statement of the Company on
  Form 8-A/A dated January&nbsp;17, 1997; and Item&nbsp;1 of Registration
  Statement of the Company on Form 8-A dated May&nbsp;2, 2003.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14 or 15(d) of the Exchange
  Act, after the date of this Registration Statement and prior to the filing of a post-effective
  amendment which indicates that all securities offered herein have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing such documents. Any statement contained herein or in a
  document incorporated by reference or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document which is incorporated
  or is deemed to be incorporated by reference herein. Any such statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this Registration
  Statement.
  </DIV>
  
  <!-- link2 "Item&nbsp;4. <U>Description of Securities</U>." -->
  <DIV align="left"><A NAME="003"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;4. <U>Description of Securities</U>.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Not Applicable
  </DIV>
  
  <!-- link2 "Item&nbsp;5. <U>Interests of Named Experts and Counsel</U>." -->
  <DIV align="left"><A NAME="004"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;5. <U>Interests of Named Experts and Counsel</U>.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Not Applicable.
  </DIV>
  
  <!-- link2 "Item&nbsp;8. <U>Exhibits</U>." -->
  <DIV align="left"><A NAME="005"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;8. <U>Exhibits</U>.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Reference is made to the Exhibit&nbsp;Index.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  <DIV align="left"><A NAME="206"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the City of Cambridge, in the Commonwealth of Massachusetts, on this
  21<SUP style="font-size: 85%; vertical-align: text-top">st</SUP> day of September&nbsp;2006.
  </DIV>
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">ALKERMES, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Richard F. Pops
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Richard F. Pops&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  
  <!-- link1 "POWER OF ATTORNEY AND SIGNATURES" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  <DIV align="left"><A NAME="207"></A></DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY AND SIGNATURES</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed below by the following persons in the capacities and on the dates indicated.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Each person whose signature appears below in so signing also makes, constitutes and appoints
  Richard F. Pops and James M. Frates, and each of them, his true and lawful attorney-in-fact, with
  full power of substitution, for him in any and all capacities, to execute and cause to be filed
  with the Securities and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in connection therewith, and
  hereby ratifies and confirms all that said attorney-in-fact or his substitute or substitutes may do
  or cause to be done by virtue hereof.
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="34%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="20%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>SIGNATURE</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>TITLE</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>DATE</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top"><DIV style="margin-left:0px; text-indent:-15px">/s/ Michael A. Wall
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Michael A. Wall</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director and Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Richard F. Pops
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Richard F. Pops</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director and Chief Executive Officer<br>
  (Principal Executive Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ James M. Frates
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  James M. Frates</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Vice President, Chief Financial Officer and
  Treasurer
  (Principal Financial and Accounting Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Floyd E. Bloom
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Floyd E. Bloom</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Robert A. Breyer
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Robert A. Breyer</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Gerri Henwood
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Gerri Henwood</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Paul J. Mitchell
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Paul J. Mitchell</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Alexander Rich
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Alexander Rich</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Paul Schimmel
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Paul Schimmel</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Mark B. Skaletsky
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Mark B. Skaletsky</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">September 21, 2006</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "INDEX TO EXHIBITS" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  <DIV align="left"><A NAME="208"></A></DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX TO EXHIBITS</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit No.</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000">Description of Exhibit</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated
  by reference to Exhibit&nbsp;4 to the Registrant&#146;s Registration Statement
  on Form&nbsp;S-1, as amended (File No.&nbsp;33-40250).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen of Non-Voting Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4.2 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-8, as amended, filed on April&nbsp;22,
  2005).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Report
  on Form&nbsp;8-K filed on December&nbsp;13, 2002.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Indenture, dated as of February&nbsp;18, 2000, between Alkermes, Inc. and
  State Street Bank and Trust Company, as Trustee. (3.75% Subordinated
  Notes) (Incorporated by reference to Exhibit&nbsp;4.6 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-3, as amended, filed on February&nbsp;29,
  2000 (File No.&nbsp;333-31354).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of 3.75% Subordinated Note (Incorporated by reference to Exhibit
  4.6 to the Registrant&#146;s Registration Statement on Form&nbsp;S-3, as
  amended, filed on February&nbsp;29, 2000 (File No.&nbsp;333-31354).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.6
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, dated as of February&nbsp;7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Report
  on Form&nbsp;8-A filed on May&nbsp;2, 2003.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.7
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Indenture, dated February&nbsp;1, 2005, between RC Royalty Sub LLC and U.S.
  Bank National Association, as Trustee (Risperdal Consta <SUP style="font-size: 85%; vertical-align: text-top">&#174;</SUP> PhaRMA
  (SM) secured 7% Notes due 2018, Class&nbsp;A). (Incorporated by
  reference to Exhibit&nbsp;4.1 to Registrant&#146;s Report on Form&nbsp;8-K filed on
  February&nbsp;3, 2005) (File No.&nbsp;001-14131).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.8
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Risperdal Consta <SUP style="font-size: 85%; vertical-align: text-top">&#174;</SUP> PhaRMA (SM) secured 7% Notes due
  2018, Class&nbsp;A (Incorporated by reference to Exhibit&nbsp;A to Exhibit&nbsp;4.1
  to the Registrant&#146;s Report on Form&nbsp;8-K filed on February&nbsp;3, 2005)
  (File No.&nbsp;001-14131).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.9
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Alkermes, Inc. 1999 Stock Option Plan, as amended (Incorporated by
  reference to Exhibit&nbsp;10.1 to the Registrant&#146;s Report on Form&nbsp;10-Q for
  the quarter ended September&nbsp;30, 2004) (File No.&nbsp;001-14131).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.10
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Stock Option Certificate pursuant to the 1999 Stock Option
  Plan, as amended (Incorporated by reference to Exhibit&nbsp;10.36 to the
  Registrant&#146;s Report on Form&nbsp;10-K for the year ended March&nbsp;31, 2006)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Ballard Spahr Andrews &#038; Ingersoll (filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ballard Spahr Andrews &#038; Ingersoll (included in Exhibit&nbsp;5.1).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included in signature page).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on September 22, 2006
  Registration No. 333-_________
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER
  THE SECURITIES ACT OF 1933
  Alkermes, Inc.
  (Exact Name of Registrant as specified in its charter)
  Pennsylvania
  23-2472830
  (State or other jurisdiction of incorporation or organization)
  (I.R.S. Employer Identification No.)
  ALKERMES, INC.
  88 SIDNEY STREET
  CAMBRIDGE, MASSACHUSETTS 02139-4234
  TELEPHONE: (617) 494-0171
  (Address, including zip code, and telephone number, including area code,
  of registrant's principal executive offices)
  ALKERMES, INC. 2002 RESTRICTED STOCK AWARD PLAN
  (Full title of the plan)
  Richard F. Pops
  Chief Executive Officer
  ALKERMES, INC.
  88 Sidney Street
  Cambridge, Massachusetts 02139-4234
  Telephone: (617) 494-0171
  (Name, address, including zip code, and telephone number, including area code,
  of agent for service)
  Copies to:
  Mitchell S. Bloom, Esq.
  Kathryn L. Biberstein, Esq.
  Robert E. Puopolo
  Alkermes, Inc.
  Goodwin Procter LLP
  88 Sidney Street
  53 State Street
  Cambridge, MA 02139
  Boston, MA 02109
  Telephone: (617) 583-6255
  Telephone: (617) 570-1055
  CALCULATION OF REGISTRATION FEE
  Proposed Maximum
  Proposed Maximum
  Amount to be
  Offering Price Per
  Aggregate Offering
  Amount of
  Title of Securities
  Registered (1)(3)
  Share
  Price
  Registration Fee
  Common Stock
  300,000
  $
  14.69
  (2)
  $
  4,407,000
  $
  471.55
  Totals:
  300,000
  $
  4,407,000
  $
  471.55
  (1)
  Pursuant to Rule 416 under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend, recapitalization, and certain other
  capital adjustments and the like.
  (2)
  Estimated solely for the purpose of calculating the registration fee.
  In accordance with Rules 457(c) and 457(h), the proposed maximum
  offering price per share, the proposed maximum aggregate offering
  price, and the registration fee shown has been computed based upon the
  average of the high and low sales price of the Company's Common Stock
  on September 15, 2006, $14.69, as reported on the Nasdaq Global Market
  with respect to securities for which options have not been granted.
  (3)
  This registration statement relates 300,000 shares of Common Stock,
  $.01 par value per share, reserved for issuance under the 2002
  Restricted Stock Award Plan (the "2002 Plan"), which shares are in
  addition to 500,000 shares of Common Stock, $0.01 par value per share,
  previously registered pursuant to Registration Statements on Form S-8
  (Registration Nos. 333-107208) and filed with the Securities and
  Exchange Commission. The current filing is being made to register the
  300,000 shares which are issuable under the 2002 Plan.
  TABLE OF CONTENTS
  PART I
  PART II
  Item 3.
  Incorporation of Documents by Reference
  .
  Item 4.
  Description of Securities
  .
  Item 5.
  Interests of Named Experts and Counsel
  .
  Item 8.
  Exhibits
  .
  SIGNATURES
  POWER OF ATTORNEY AND SIGNATURES
  INDEX TO EXHIBITS
  Ex-5.1 Opinion of Ballard Spahr Andrews & Ingersoll
  Ex-23.2 Consent of Deloitte & Touche LLP
  Table of Contents
  PART I
  Part I and Items 6, 7 and 9 of Part II of Alkermes, Inc.'s Registration Statement on Form S-8
  (File No. 333-89573) are incorporated by reference herein pursuant to Instruction E of Form S-8.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference
  .
  The following documents filed with the Securities and Exchange Commission (the "Commission")
  pursuant to the Securities Exchange Act of 1934 (the "Exchange Act") by Alkermes, Inc. (the
  "Company") (File No. 1-14131) or pursuant to the Securities Act of 1933, as amended (the
  "Securities Act") are incorporated herein by reference:
  (a)
  Annual Report on Form 10-K for the fiscal year ended March 31, 2006
  filed on June 14, 2006 and as amended by an Amendment No. 1 to Annual
  Report on Form 10-K/A for the fiscal year ended March 31, 2006 filed
  on August 14, 2006;
  (b)
  Quarterly Report on Form 10-Q for the period ended June 30, 2006;
  (c)
  All other documents filed by the Company pursuant to 13(a) or 15(d) of
  the Exchange Act since the end of the fiscal year covered by the
  document referred to in (a) above; and
  (d)
  Item 1 of Registration Statement of the Company on Form 8-A dated June
  28, 1991, as amended by a Registration Statement of the Company on
  Form 8-A/A dated January 17, 1997; and Item 1 of Registration
  Statement of the Company on Form 8-A dated May 2, 2003.
  All documents filed by the Company pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange
  Act, after the date of this Registration Statement and prior to the filing of a post-effective
  amendment which indicates that all securities offered herein have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing such documents. Any statement contained herein or in a
  document incorporated by reference or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document which is incorporated
  or is deemed to be incorporated by reference herein. Any such statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this Registration
  Statement.
  Item 4.
  Description of Securities
  .
  Not Applicable
  Item 5.
  Interests of Named Experts and Counsel
  .
  Not Applicable.
  Item 8.
  Exhibits
  .
  Reference is made to the Exhibit Index.
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the City of Cambridge, in the Commonwealth of Massachusetts, on this
  21
  st
  day of September 2006.
  ALKERMES, INC.
  By:
  /s/ Richard F. Pops
  Richard F. Pops
  Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed below by the following persons in the capacities and on the dates indicated.
  Each person whose signature appears below in so signing also makes, constitutes and appoints
  Richard F. Pops and James M. Frates, and each of them, his true and lawful attorney-in-fact, with
  full power of substitution, for him in any and all capacities, to execute and cause to be filed
  with the Securities and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in connection therewith, and
  hereby ratifies and confirms all that said attorney-in-fact or his substitute or substitutes may do
  or cause to be done by virtue hereof.
  SIGNATURE
  TITLE
  DATE
  /s/ Michael A. Wall
  Michael A. Wall
  Director and Chairman of the Board
  September 21, 2006
  /s/ Richard F. Pops
  Richard F. Pops
  Director and Chief Executive Officer
  (Principal Executive Officer)
  September 21, 2006
  /s/ James M. Frates
  James M. Frates
  Vice President, Chief Financial Officer and
  Treasurer
  (Principal Financial and Accounting Officer)
  September 21, 2006
  /s/ Floyd E. Bloom
  Floyd E. Bloom
  Director
  September 21, 2006
  /s/ Robert A. Breyer
  Robert A. Breyer
  Director
  September 21, 2006
  /s/ Gerri Henwood
  Gerri Henwood
  Director
  September 21, 2006
  /s/ Paul J. Mitchell
  Paul J. Mitchell
  Director
  September 21, 2006
  /s/ Alexander Rich
  Alexander Rich
  Director
  September 21, 2006
  /s/ Paul Schimmel
  Paul Schimmel
  Director
  September 21, 2006
  /s/ Mark B. Skaletsky
  Mark B. Skaletsky
  Director
  September 21, 2006
  Table of Contents
  INDEX TO EXHIBITS
  Exhibit No.
  Description of Exhibit
  4.1
  Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated
  by reference to Exhibit 4 to the Registrant's Registration Statement
  on Form S-1, as amended (File No. 33-40250).)
  4.2
  Specimen of Non-Voting Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4.2 to the Registrant's
  Registration Statement on Form S-8, as amended, filed on April 22,
  2005).
  4.3
  Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's Report
  on Form 8-K filed on December 13, 2002.)
  4.4
  Indenture, dated as of February 18, 2000, between Alkermes, Inc. and
  State Street Bank and Trust Company, as Trustee. (3.75% Subordinated
  Notes) (Incorporated by reference to Exhibit 4.6 to the Registrant's
  Registration Statement on Form S-3, as amended, filed on February 29,
  2000 (File No. 333-31354).)
  4.5
  Form of 3.75% Subordinated Note (Incorporated by reference to Exhibit
  4.6 to the Registrant's Registration Statement on Form S-3, as
  amended, filed on February 29, 2000 (File No. 333-31354).)
  4.6
  Rights Agreement, dated as of February 7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's Report
  on Form 8-A filed on May 2, 2003.)
  4.7
  Indenture, dated February 1, 2005, between RC Royalty Sub LLC and U.S.
  Bank National Association, as Trustee (Risperdal Consta
  ®
  PhaRMA
  (SM) secured 7% Notes due 2018, Class A). (Incorporated by
  reference to Exhibit 4.1 to Registrant's Report on Form 8-K filed on
  February 3, 2005) (File No. 001-14131).)
  4.8
  Form of Risperdal Consta
  ®
  PhaRMA (SM) secured 7% Notes due
  2018, Class A (Incorporated by reference to Exhibit A to Exhibit 4.1
  to the Registrant's Report on Form 8-K filed on February 3, 2005)
  (File No. 001-14131).)
  4.9
  Alkermes, Inc. 1999 Stock Option Plan, as amended (Incorporated by
  reference to Exhibit 10.1 to the Registrant's Report on Form 10-Q for
  the quarter ended September 30, 2004) (File No. 001-14131).)
  4.10
  Form of Stock Option Certificate pursuant to the 1999 Stock Option
  Plan, as amended (Incorporated by reference to Exhibit 10.36 to the
  Registrant's Report on Form 10-K for the year ended March 31, 2006)
  5.1
  Opinion of Ballard Spahr Andrews & Ingersoll (filed herewith).
  23.1
  Consent of Ballard Spahr Andrews & Ingersoll (included in Exhibit 5.1).
  23.2
  Consent of Deloitte & Touche LLP (filed herewith).
  24.1
  Power of Attorney (included in signature page).