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  <TITLE>ANTIGENICS INC.</TITLE>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <P align="center"><FONT size="2">As filed with the Securities and Exchange Commission on June&nbsp;11, 2003
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  Registration No.&nbsp;333-</FONT></TD>
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      <TD width="14%" align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
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  <DIV align="center"><FONT size="4">UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION
  </FONT></DIV>
  
  <DIV align="center"><FONT size="3">Washington, D.C. 20549
  </FONT></DIV>
  <DIV align="center"><FONT size="2">&nbsp;
  </FONT></DIV>
  <DIV align="center"><HR align="center" size="1" width="50%" noshade></DIV>
  <P align="center"><FONT size="5">FORM S-8
  </FONT>
  
  <P align="center"><FONT size="3">REGISTRATION STATEMENT<BR>
  UNDER<BR>
  THE SECURITIES ACT OF 1933
  </FONT>
  
  <P align="center"><HR align="center" size="1" width="50%" noshade>
  
  <P align="center"><FONT size="6"><B>ANTIGENICS INC.</B>
  </FONT>
  
  <DIV align="center"><FONT size="2">(Exact name of registrant as specified in its charter)
  </FONT></DIV>
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  <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2"><B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Delaware</B></FONT></DIV></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right"><FONT size="2"><B>06-1562417</B></FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
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  <TD colspan="2"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">(State or other jurisdiction</FONT></DIV></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD colspan="3" align="center"><FONT size="2">(I.R.S. Employer</FONT></TD>
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      <TD colspan="3"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">of incorporation or organization)</FONT></DIV></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD colspan="3" align="center"><FONT size="2">Identification No.)</FONT></TD>
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  <P align="center"><FONT size="2">Antigenics Inc.<BR>
  630 Fifth Avenue, Suite&nbsp;2100<BR>
  New York, NY 10111<BR>
  (Address of principal executive offices, including zip code)
  </FONT>
  
  <P align="center"><HR align="center" size="1" width="50%" noshade>
  
  <P align="center"><FONT size="2"><B>DIRECTORS&#146; DEFERRED COMPENSATION PLAN</B><BR>
  (Full title of the plan)
  </FONT>
  
  <P align="center"><FONT size="2">Garo H. Armen, Ph.D<BR>
  Antigenics Inc.<BR>
  630 Fifth Avenue, Suite&nbsp;2100<BR>
  New York, NY 10111<BR>
  212-994-8200<BR>
  (Name, address and telephone number, including area code, of agent for service)
  </FONT>
  
  <P align="center"><HR align="center" size="1" width="50%" noshade>
  
  <P align="center"><FONT size="2">Please send copies of all communications to:<BR>
  Paul M. Kinsella, Esq.<BR>
  Ropes &#038; Gray<BR>
  One International Place<BR>
  Boston, MA 02110<BR>
  617-951-7000<BR>
  617-951-7050 (facsimile)
  </FONT>
  
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      <TD align="center" nowrap><FONT size="1"><B>Title of Each Class of Securities</B></FONT></TD>
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      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum Offering</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
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      <TD nowrap align="center"><FONT size="1"><B>to be Registered</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount to be Registered</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price Per Share(1)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate Offering Price(1)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration Fee</B></FONT></TD>
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      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD><DIV style="margin-left=10px;text-indent=-10px"><FONT size="2">Common Stock, $0.01 par<BR>
  value per share</FONT></DIV></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD colspan="3" align="center"><FONT size="2">100,000 shares(2)</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">14.94</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">1,494,000</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">121</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="96%"><FONT size="2">Pursuant to Rules&nbsp;457(c) and 457(h)(1) under the Securities Act of 1933,
  the proposed maximum offering price per share and the maximum aggregate
  offering price for the shares have been calculated solely for the purpose
  of computing the registration fee on the basis of the average high and low
  prices of the Common Stock as reported by the Nasdaq National Market on
  June&nbsp;6, 2003 to be $15.78 and $14.10, respectively.</FONT></TD>
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      <TD><FONT size="2">&nbsp;</FONT></TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416(a) under the Securities Act of 1933, this
  registration statement also covers such additional shares of
  Common Stock as may issued to prevent dilution from stock splits, stock
  dividends and similar transactions.</FONT></TD>
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  <P align="center"><FONT size="2"></FONT>
  
  
  
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  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
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  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item 3. Incorporation of Documents by Reference</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item 4. Description of Securities</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item 5. Interests of Named Experts and Counsel</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item 6. Indemnification of Directors and Officers</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item 7. Exemption From Registration Claimed</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item 8. Exhibits</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item 9. Undertakings</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#008">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#009">POWER OF ATTORNEY</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#010">EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b46833s8exv4w1.txt">EX-4.1 DIRECTORS' DEFERRED COMPENSATION PLAN</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b46833s8exv5w1.txt">EX-5.1 OPINION OF ROPES & GRAY LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b46833s8exv23w1.txt">EX-23.1 CONSENT OF KPMG LLP</A></TD></TR>
  </TABLE>
  </CENTER>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  <!-- link1 "PART II" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  <P align="center"><FONT size="2"><B>PART II</B>
  </FONT>
  
  <P align="center"><FONT size="2"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  </FONT>
  
  <!-- link2 "Item 3. Incorporation of Documents by Reference" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Antigenics Inc., a Delaware corporation (the &#147;Registrant&#148;), hereby
  incorporates the following documents herein by reference:
  </FONT>
  <P>
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      <TD width="2%"></TD>
      <TD width="98%"></TD>
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      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The Registrant&#146;s latest annual report on Form&nbsp;10-K for the
  fiscal year ended December&nbsp;31, 2002, filed with the Securities and
  Exchange Commission (the &#147;Commission&#148;) pursuant to the Securities
  Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;), on March&nbsp;27, 2003.</FONT></TD>
  </TR>
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  <P>
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      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;All other reports filed with the Commission pursuant to Section
  13(a) or 15(d) of the Exchange Act subsequent to December&nbsp;31, 2002.</FONT></TD>
  </TR>
  </TABLE>
  <P>
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      <TD width="2%"></TD>
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      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;The description of the Common Stock, $0.01 par value per share,
  contained in the Registrant&#146;s Registration Statement on Form&nbsp;8-A, filed
  with the Commission pursuant to Section&nbsp;12 of the Exchange Act on January
  24, 2000, including any amendment or report updating such description.</FONT></TD>
  </TR>
  </TABLE>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents subsequently filed by the Registrant pursuant to Sections
  13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a
  post-effective amendment to this Registration Statement that indicates that all
  securities offered have been sold or which deregisters all securities then
  remaining unsold, shall be deemed to be incorporated herein by reference from
  the date of filing of such documents.
  </FONT>
  <!-- link2 "Item 4. Description of Securities" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;4. Description of Securities.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </FONT>
  <!-- link2 "Item 5. Interests of Named Experts and Counsel" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </FONT>
  <!-- link2 "Item 6. Indemnification of Directors and Officers" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant is incorporated under the laws of the State of Delaware.
  Section&nbsp;145 (&#147;Section&nbsp;145&#148;) of the General Corporation Law of the State of
  Delaware, as the same exists or may hereafter be amended (the &#147;General
  Corporation Law&#148;), inter alia, provides that a Delaware corporation may
  indemnify any persons who were, are or are threatened to be made, parties to
  any threatened, pending or completed action, suit or proceeding, whether civil,
  criminal, administrative or investigative (other than an action by or in the
  right of such corporation), by reason of the fact that such person is or was an
  officer, director, employee or agent of such corporation, or is or was serving
  at the request of such corporation as a director, officer, employee or agent of
  another corporation or enterprise. The indemnity may include expenses
  (including attorneys&#146; fees), judgments, fines and amounts paid in settlement
  actually and reasonably incurred by such person in connection with such action,
  suit or proceeding, provided
  </FONT>
  <P align="center"><FONT size="2">&nbsp;</FONT>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <P align="left"><FONT size="2"> such person acted in good faith and in a manner he reasonably believed to
  be in or not opposed to the corporation&#146;s best interests and, with respect to
  any criminal action or proceeding, had no reasonable cause to believe that his
  conduct was illegal. In addition, the statutes of Delaware contain provisions
  to the general effect that any director shall in the performance of his duties
  be fully protected in relying in good faith upon the books of account or
  records of the corporation or statements prepared by any official of the
  corporation.
  </FONT>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 further authorizes a corporation to purchase and maintain
  insurance on behalf of any person who is or was a director, officer, employee
  or agent of the corporation, or is or was serving at the request of the
  corporation as a director, officer, employee or agent of another corporation or
  enterprise, against any liability asserted against him and incurred by him in
  any such capacity, arising out of his status as such, whether or not the
  corporation would otherwise have the power to indemnify him under Section&nbsp;145.
  </FONT>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant&#146;s amended and restated certificate of incorporation
  provides that the registrant&#146;s directors and officers shall not be liable to
  the registrant or its stockholders for monetary damages for breach of fiduciary
  duty as a director, except to the extent that the exculpation from liabilities
  is not permitted under the General Corporation Law as in effect at the time
  such liability is determined. In addition, Article&nbsp;V of the Registrant&#146;s
  by-laws provides that the Registrant shall, to the extent legally permitted,
  indemnify each person who was or is a party or is threatened to be made a party
  to any threatened, pending or completed action, suit or proceeding by reason of
  the fact that he is or was, or has agreed to become, a director or officer of
  the Registrant, or is or was serving, or has agreed to serve at the request of
  the Registrant, as a director, officer or trustee of, or in a similar capacity
  with, another corporation, partnership, joint venture, trust or other
  enterprise. The indemnification provided for in Article&nbsp;V is expressly not
  exclusive of any other rights to which those seeking indemnification may be
  entitled under any law, agreement or vote of stockholders or disinterested
  directors or otherwise, and shall inure to the benefit of the heirs, executors
  and administrators of such persons.
  </FONT>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All of the Registrant&#146;s directors and officers are covered by insurance
  policies maintained by the Registrant against specified liabilities for actions
  taken in their capacities as such, including liabilities under the Securities
  Act of 1933, as amended. In addition, the Registrant has entered into
  indemnification agreements with each of its directors and executive officers
  that provide for indemnification and expense advancement to the fullest extent
  permitted under the General Corporation Law.
  </FONT>
  <!-- link2 "Item 7. Exemption From Registration Claimed" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;7. Exemption From Registration Claimed.</B>
  </FONT>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </FONT>
  <!-- link2 "Item 8. Exhibits" -->
  <DIV align="left"><A NAME="006"></A></DIV>
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      <TD width="3%">&nbsp;</TD>
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      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="93%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
  
  <TD valign="top" nowrap colspan="5" align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits.</B></FONT></TD>
  
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
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      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
  
      <TD align="left" valign="top" colspan="2"><FONT size="2">
  &nbsp;Exhibits</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
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      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
  
      <TD align="left" valign="top" colspan="2"><FONT size="2">&nbsp;
  4.1
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Antigenics Inc. Directors&#146; Deferred Compensation Plan.</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">2</FONT>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <CENTER>
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  <TR valign="bottom">
      <TD width="3%">&nbsp;</TD>
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      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top" colspan="2"><FONT size="2">&nbsp;
  4.2
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Amended and Restated Certificate of Incorporation of
  Antigenics Inc. (previously filed as Exhibit&nbsp;3.1 to the Current
  Report on Form&nbsp;8-K dated June&nbsp;10, 2002, File No.&nbsp;000-29089).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
  
      <TD align="left" valign="top" colspan="2"><FONT size="2">&nbsp;
  4.3
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Amended and Restated By-laws of Antigenics Inc. (previously
  filed as Exhibit&nbsp;3.2 to the Current Report on Form&nbsp;8-K dated June
  10, 2002, File No.&nbsp;000-29089).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
  
      <TD align="left" valign="top" colspan="2"><FONT size="2">&nbsp;
  5.1
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Opinion of Ropes
  &#038; Gray LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
  
      <TD nowrap align="left" valign="top" colspan="2"><FONT size="2">&nbsp;
  23.1
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Consent of KPMG LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
  
      <TD align="left" valign="top" colspan="2"><FONT size="2">&nbsp;
  23.2
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Consent of Ropes
  &#038; Gray LLP (included in the opinion filed as Exhibit&nbsp;5.1).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top" colspan="2"><FONT size="2">&nbsp;
  24.1
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Powers of Attorney (included on the signature page in Part II).</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <!-- link2 "Item 9. Undertakings" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;9. Undertakings.</B>
  </FONT>
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR valign="top">
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="2%" align="left" nowrap><FONT size="2">(a)</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="94%" colspan="5"><FONT size="2">The undersigned Registrant hereby undertakes:</FONT></TD>
  </TR>
  <TR>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="top">
      <TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="2%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="91%" colspan="3"><FONT size="2">To file, during any period in which offers or
  sales are being made, a post-effective amendment to this
  Registration Statement:</FONT></TD>
  </TR>
  <TR>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  
  <TR valign="top">
      <TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="2%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(i)</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="89%"><FONT size="2">To include any prospectus required by
  Section&nbsp;10(a)(3) of the Securities Act of 1933, as
  amended (the &#147;Securities Act&#148;);</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  
  </TR>
  <TR valign="top">
      <TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="2%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(ii)</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="89%"><FONT size="2">To reflect in the prospectus any
  facts or events arising after the effective date of the
  Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the
  information set forth in the Registration Statement.
  Notwithstanding the foregoing, any increase or decrease
  in volume of securities offered (if the total dollar
  value of securities offered would not exceed that which
  was registered) and any deviation from the low or high
  end of the estimated maximum offering range may be
  reflected in the form of a prospectus filed with the
  Commission pursuant to Rule&nbsp;424(b) if, in the aggregate,
  the changes in volume and price represent no more than
  20&nbsp;percent change in the maximum aggregate offering
  price set forth in the &#147;Calculation of Registration Fee&#148;
  table in the effective registration statement;</FONT></TD>
  </TR>
  <TR>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="2%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(iii)</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="89%"><FONT size="2">To include any material information
  with respect to the plan of distribution not previously
  disclosed in the Registration Statement or any material
  change to such information in the Registration
  Statement;</FONT></TD>
  </TR>
  <TR>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="4%" align="left" nowrap><FONT size="2"><I>&nbsp;</I></FONT></TD>
      <TD width="2%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%" colspan="5"><FONT size="2"><I>provided, however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii) above
  shall not apply if the information required to be included in a
  post-effective amendment by those paragraphs is contained in
  periodic reports filed with or furnished to the</FONT></TD>
  </TR>
  </TABLE>
  <P align="center"><FONT size="2">3</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR valign="top">
      <TD width="4%" align="left" nowrap><FONT size="2"><I>&nbsp;</I></FONT></TD>
      <TD width="2%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%" colspan="5"><FONT size="2">Commission by the Registrant pursuant to Section&nbsp;13 or 15(d) of the
  Exchange Act that are incorporated by reference in the Registration
  Statement.</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="top">
      <TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="2%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="91%" colspan="3"><FONT size="2">That, for the purpose of determining any
  liability under the Securities Act, each such post-effective
  amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering
  of such securities at that time shall be deemed to be the
  initial <I>bona fide </I>offering thereof.</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="2%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="91%" colspan="3"><FONT size="2">To remove from registration by means of a
  post-effective amendment any of the securities being
  registered which remain unsold at the termination of the
  offering.</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="2%" align="left" nowrap><FONT size="2">(b)</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%" colspan="5"><FONT size="2">The undersigned Registrant hereby undertakes that, for
  purposes of determining any liability under the Securities Act, each
  filing of the Registrant&#146;s annual report pursuant to Section&nbsp;13(a)
  or 15(d) of the Exchange Act (and, where applicable, each filing of
  an employee benefit plan&#146;s annual report pursuant to Section&nbsp;15(d)
  of the Exchange Act) that is incorporated by reference in the
  Registration Statement shall be deemed to be a new Registration
  Statement relating to the securities offered therein, and the
  offering of such securities at that time shall be deemed to be the
  initial <I>bona fide </I>offering thereof.</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="2%" align="left" nowrap><FONT size="2">(c)</FONT></TD>
      <TD width="1%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%" colspan="5"><FONT size="2">Insofar as indemnification for liabilities arising under the
  Securities Act may be permitted to directors, officers and
  controlling persons of the Registrant pursuant to the foregoing
  provisions, or otherwise, the Registrant has been advised that in
  the opinion of the Commission such indemnification is against public
  policy as expressed in the Securities Act and is, therefore,
  unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant
  of expenses incurred or paid by a director, officer or controlling
  person of the Registrant in the successful defense of any action,
  suit or proceeding) is asserted by such director, officer or
  controlling person in connection with the securities being
  registered, the Registrant will, unless in the opinion of its
  counsel the matter has been settled by controlling precedent, submit
  to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the
  Securities Act and will be governed by the final adjudication of
  such issue.</FONT></TD>
  </TR>
  </TABLE>
  <P align="center"><FONT size="2">4</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  <P align="center"><FONT size="2"><B>SIGNATURES</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form&nbsp;S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of New York, State of New York, on this 11th day of
  June, 2003.
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="55%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="39%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
     <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top" colspan="4"><FONT size="2">ANTIGENICS INC.</FONT></TD>
  </TR>
  <TR valign="bottom">
     <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">By:</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top" colspan="2"><FONT size="2">
  /s/ Garo H. Armen, Ph.D.<BR>
  </FONT><HR size="1" noshade width="50%">
  </TR>
  <TR valign="bottom">
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Name:
  </FONT></TD>
   <TD align="left" valign="top" ><FONT size="2">
  Garo H. Armen, Ph.D.<BR>
  </FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Title:
  </FONT></TD>
   <TD align="left" valign="top" ><FONT size="2">
  Chief Executive Officer and Chairman<BR>
  of the Board</FONT></TD>
  </TR>
  
  </TABLE>
  </CENTER>
  <!-- link1 "POWER OF ATTORNEY" -->
  <DIV align="left"><A NAME="009"></A></DIV>
  <P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Garo
  Armen and Jeffrey Clark, and each of them singly, his or her true and lawful
  attorney-in-fact and agent with full power of substitution and resubstitution,
  for him or her and in his or her name, place and stead, in any and all
  capacities, to sign any and all amendments (including post-effective
  amendments) to this Registration Statement on Form&nbsp;S-8 to be filed by
  Antigenics Inc., and to file the same, with all exhibits thereto, and other
  documents in connection therewith, with the Securities and Exchange Commission,
  granting unto said attorneys-in-fact and agents full power and authority to be
  done in and about the premises, as fully to all intents and purposes as he or
  she might or could do in person, hereby ratifying and confirming all that said
  attorneys-in-fact and agents, or their substitutes, may lawfully do or cause to
  be done by virtue hereof.
  </FONT>
  <P align="center"><FONT size="2">* * * *
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
  this Registration Statement has been signed by the following persons in the
  capacities indicated as of June&nbsp;11, 2003.
  </FONT>
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="33%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="62%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2"><B>Signature</B></FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  <B>Title</B></FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" ><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Garo H. Armen, Ph.D.
  <HR size="1" noshade width="60%">
  Garo H. Armen, Ph.D.</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Chief Executive Officer and Chairman of <BR>
  the Board of Directors<BR>
  (Principal Executive Officer)<BR></FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Jeff D. Clark
  <HR size="1" noshade  width="50%">
  Jeff D. Clark</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Chief Financial Officer<BR>
  (Principal Financial Officer<BR>
  and Principal Accounting Officer)<BR></FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Noubar Afeyan, Ph.D.
  <HR size="1" noshade  width="60%">
  Noubar Afeyan, Ph.D</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">&nbsp;</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="33%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="62%">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Frank AtLee
  <HR size="1" noshade  width="50%">
  Frank AtLee</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Gamil de Chadarevian
  <HR size="1" noshade  width="60%">
  Gamil de Chadarevian</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director, Vice Chairman of the Board</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Tom Dechaene
  <HR size="1" noshade  width="50%">
  Tom Dechaene</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Margaret Eisen
  <HR size="1" noshade width="50%">
  Margaret Eisen</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Wadih Jordan
  <HR size="1" noshade  width="50%">
  Wadih Jordan</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Mark Kessel
  <HR size="1" noshade  width="50%">
  Mark Kessel</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top" align="left"><FONT size="2">/s/ Pramod Srivastava
  <HR size="1" noshade  width="50%">
  Pramod Srivastava</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">&nbsp;</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <!-- link1 "EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="010"></A></DIV>
  <P align="center"><FONT size="2"><B>EXHIBIT INDEX</B>
  </FONT>
  
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  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
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      <TD width="3%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="94%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Antigenics Inc. Directors&#146; Deferred Compensation Plan.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Amended and Restated Certificate of Incorporation of Antigenics Inc.
  (previously filed as Exhibit&nbsp;3.1 to the Current Report on Form&nbsp;8-K dated
  June&nbsp;10, 2002, File No.&nbsp;000-29089).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Amended and Restated By-laws of Antigenics Inc. (previously filed as
  Exhibit&nbsp;3.2 to the Current Report on Form&nbsp;8-K dated June&nbsp;10, 2002, File
  No.&nbsp;000-29089).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">5.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Opinion of Ropes &#038; Gray LLP.</FONT></TD>
  </TR>
  
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      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
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  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of KPMG LLP.</FONT></TD>
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      <TD><FONT size="2">&nbsp;</FONT></TD>
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  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Ropes &#038; Gray LLP (included in the opinion filed as Exhibit&nbsp;5.1).</FONT></TD>
  </TR>
  
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      <TD><FONT size="2">&nbsp;</FONT></TD>
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  <TR valign="bottom">
      <TD valign="top"><FONT size="2">24.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Powers of Attorney (included on the signature page in Part II).</FONT></TD>
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text: ANTIGENICS INC.
  Table of Contents
  As filed with the Securities and Exchange Commission on June 11, 2003
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  ANTIGENICS INC.
  (Exact name of registrant as specified in its charter)
  Delaware
  06-1562417
  (State or other jurisdiction
  (I.R.S. Employer
  of incorporation or organization)
  Identification No.)
  Antigenics Inc.
  630 Fifth Avenue, Suite 2100
  New York, NY 10111
  (Address of principal executive offices, including zip code)
  DIRECTORS' DEFERRED COMPENSATION PLAN
  (Full title of the plan)
  Garo H. Armen, Ph.D
  Antigenics Inc.
  630 Fifth Avenue, Suite 2100
  New York, NY 10111
  212-994-8200
  (Name, address and telephone number, including area code, of agent for service)
  Please send copies of all communications to:
  Paul M. Kinsella, Esq.
  Ropes & Gray
  One International Place
  Boston, MA 02110
  617-951-7000
  617-951-7050 (facsimile)
  Title of Each Class of Securities
  Proposed Maximum Offering
  Proposed Maximum
  Amount of
  to be Registered
  Amount to be Registered
  Price Per Share(1)
  Aggregate Offering Price(1)
  Registration Fee
  Common Stock, $0.01 par
  value per share
  100,000 shares(2)
  $
  14.94
  $
  1,494,000
  $
  121
  (1)
  Pursuant to Rules 457(c) and 457(h)(1) under the Securities Act of 1933,
  the proposed maximum offering price per share and the maximum aggregate
  offering price for the shares have been calculated solely for the purpose
  of computing the registration fee on the basis of the average high and low
  prices of the Common Stock as reported by the Nasdaq National Market on
  June 6, 2003 to be $15.78 and $14.10, respectively.
  (2)
  Pursuant to Rule 416(a) under the Securities Act of 1933, this
  registration statement also covers such additional shares of
  Common Stock as may issued to prevent dilution from stock splits, stock
  dividends and similar transactions.
  TABLE OF CONTENTS
  PART II
  Item 3. Incorporation of Documents by Reference
  Item 4. Description of Securities
  Item 5. Interests of Named Experts and Counsel
  Item 6. Indemnification of Directors and Officers
  Item 7. Exemption From Registration Claimed
  Item 8. Exhibits
  Item 9. Undertakings
  SIGNATURES
  POWER OF ATTORNEY
  EXHIBIT INDEX
  EX-4.1 DIRECTORS' DEFERRED COMPENSATION PLAN
  EX-5.1 OPINION OF ROPES & GRAY LLP
  EX-23.1 CONSENT OF KPMG LLP
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference.
  Antigenics Inc., a Delaware corporation (the "Registrant"), hereby
  incorporates the following documents herein by reference:
  (a) The Registrant's latest annual report on Form 10-K for the
  fiscal year ended December 31, 2002, filed with the Securities and
  Exchange Commission (the "Commission") pursuant to the Securities
  Exchange Act of 1934, as amended (the "Exchange Act"), on March 27, 2003.
  (b) All other reports filed with the Commission pursuant to Section
  13(a) or 15(d) of the Exchange Act subsequent to December 31, 2002.
  (c) The description of the Common Stock, $0.01 par value per share,
  contained in the Registrant's Registration Statement on Form 8-A, filed
  with the Commission pursuant to Section 12 of the Exchange Act on January
  24, 2000, including any amendment or report updating such description.
  All documents subsequently filed by the Registrant pursuant to Sections
  13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a
  post-effective amendment to this Registration Statement that indicates that all
  securities offered have been sold or which deregisters all securities then
  remaining unsold, shall be deemed to be incorporated herein by reference from
  the date of filing of such documents.
  Item 4. Description of Securities.
  Not applicable.
  Item 5. Interests of Named Experts and Counsel.
  Not applicable.
  Item 6. Indemnification of Directors and Officers.
  The Registrant is incorporated under the laws of the State of Delaware.
  Section 145 ("Section 145") of the General Corporation Law of the State of
  Delaware, as the same exists or may hereafter be amended (the "General
  Corporation Law"), inter alia, provides that a Delaware corporation may
  indemnify any persons who were, are or are threatened to be made, parties to
  any threatened, pending or completed action, suit or proceeding, whether civil,
  criminal, administrative or investigative (other than an action by or in the
  right of such corporation), by reason of the fact that such person is or was an
  officer, director, employee or agent of such corporation, or is or was serving
  at the request of such corporation as a director, officer, employee or agent of
  another corporation or enterprise. The indemnity may include expenses
  (including attorneys' fees), judgments, fines and amounts paid in settlement
  actually and reasonably incurred by such person in connection with such action,
  suit or proceeding, provided
  Table of Contents
  such person acted in good faith and in a manner he reasonably believed to
  be in or not opposed to the corporation's best interests and, with respect to
  any criminal action or proceeding, had no reasonable cause to believe that his
  conduct was illegal. In addition, the statutes of Delaware contain provisions
  to the general effect that any director shall in the performance of his duties
  be fully protected in relying in good faith upon the books of account or
  records of the corporation or statements prepared by any official of the
  corporation.
  Section 145 further authorizes a corporation to purchase and maintain
  insurance on behalf of any person who is or was a director, officer, employee
  or agent of the corporation, or is or was serving at the request of the
  corporation as a director, officer, employee or agent of another corporation or
  enterprise, against any liability asserted against him and incurred by him in
  any such capacity, arising out of his status as such, whether or not the
  corporation would otherwise have the power to indemnify him under Section 145.
  The Registrant's amended and restated certificate of incorporation
  provides that the registrant's directors and officers shall not be liable to
  the registrant or its stockholders for monetary damages for breach of fiduciary
  duty as a director, except to the extent that the exculpation from liabilities
  is not permitted under the General Corporation Law as in effect at the time
  such liability is determined. In addition, Article V of the Registrant's
  by-laws provides that the Registrant shall, to the extent legally permitted,
  indemnify each person who was or is a party or is threatened to be made a party
  to any threatened, pending or completed action, suit or proceeding by reason of
  the fact that he is or was, or has agreed to become, a director or officer of
  the Registrant, or is or was serving, or has agreed to serve at the request of
  the Registrant, as a director, officer or trustee of, or in a similar capacity
  with, another corporation, partnership, joint venture, trust or other
  enterprise. The indemnification provided for in Article V is expressly not
  exclusive of any other rights to which those seeking indemnification may be
  entitled under any law, agreement or vote of stockholders or disinterested
  directors or otherwise, and shall inure to the benefit of the heirs, executors
  and administrators of such persons.
  All of the Registrant's directors and officers are covered by insurance
  policies maintained by the Registrant against specified liabilities for actions
  taken in their capacities as such, including liabilities under the Securities
  Act of 1933, as amended. In addition, the Registrant has entered into
  indemnification agreements with each of its directors and executive officers
  that provide for indemnification and expense advancement to the fullest extent
  permitted under the General Corporation Law.
  Item 7. Exemption From Registration Claimed.
  Not applicable.
  Item 8. Exhibits.
  Exhibits
  4.1
  Antigenics Inc. Directors' Deferred Compensation Plan.
  2
  Table of Contents
  4.2
  Amended and Restated Certificate of Incorporation of
  Antigenics Inc. (previously filed as Exhibit 3.1 to the Current
  Report on Form 8-K dated June 10, 2002, File No. 000-29089).
  4.3
  Amended and Restated By-laws of Antigenics Inc. (previously
  filed as Exhibit 3.2 to the Current Report on Form 8-K dated June
  10, 2002, File No. 000-29089).
  5.1
  Opinion of Ropes
  & Gray LLP.
  23.1
  Consent of KPMG LLP.
  23.2
  Consent of Ropes
  & Gray LLP (included in the opinion filed as Exhibit 5.1).
  24.1
  Powers of Attorney (included on the signature page in Part II).
  Item 9. Undertakings.
  (a)
  The undersigned Registrant hereby undertakes:
  (1)
  To file, during any period in which offers or
  sales are being made, a post-effective amendment to this
  Registration Statement:
  (i)
  To include any prospectus required by
  Section 10(a)(3) of the Securities Act of 1933, as
  amended (the "Securities Act");
  (ii)
  To reflect in the prospectus any
  facts or events arising after the effective date of the
  Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the
  information set forth in the Registration Statement.
  Notwithstanding the foregoing, any increase or decrease
  in volume of securities offered (if the total dollar
  value of securities offered would not exceed that which
  was registered) and any deviation from the low or high
  end of the estimated maximum offering range may be
  reflected in the form of a prospectus filed with the
  Commission pursuant to Rule 424(b) if, in the aggregate,
  the changes in volume and price represent no more than
  20 percent change in the maximum aggregate offering
  price set forth in the "Calculation of Registration Fee"
  table in the effective registration statement;
  (iii)
  To include any material information
  with respect to the plan of distribution not previously
  disclosed in the Registration Statement or any material
  change to such information in the Registration
  Statement;
  provided, however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) above
  shall not apply if the information required to be included in a
  post-effective amendment by those paragraphs is contained in
  periodic reports filed with or furnished to the
  3
  Table of Contents
  Commission by the Registrant pursuant to Section 13 or 15(d) of the
  Exchange Act that are incorporated by reference in the Registration
  Statement.
  (2)
  That, for the purpose of determining any
  liability under the Securities Act, each such post-effective
  amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering
  of such securities at that time shall be deemed to be the
  initial
  bona fide
  offering thereof.
  (3)
  To remove from registration by means of a
  post-effective amendment any of the securities being
  registered which remain unsold at the termination of the
  offering.
  (b)
  The undersigned Registrant hereby undertakes that, for
  purposes of determining any liability under the Securities Act, each
  filing of the Registrant's annual report pursuant to Section 13(a)
  or 15(d) of the Exchange Act (and, where applicable, each filing of
  an employee benefit plan's annual report pursuant to Section 15(d)
  of the Exchange Act) that is incorporated by reference in the
  Registration Statement shall be deemed to be a new Registration
  Statement relating to the securities offered therein, and the
  offering of such securities at that time shall be deemed to be the
  initial
  bona fide
  offering thereof.
  (c)
  Insofar as indemnification for liabilities arising under the
  Securities Act may be permitted to directors, officers and
  controlling persons of the Registrant pursuant to the foregoing
  provisions, or otherwise, the Registrant has been advised that in
  the opinion of the Commission such indemnification is against public
  policy as expressed in the Securities Act and is, therefore,
  unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant
  of expenses incurred or paid by a director, officer or controlling
  person of the Registrant in the successful defense of any action,
  suit or proceeding) is asserted by such director, officer or
  controlling person in connection with the securities being
  registered, the Registrant will, unless in the opinion of its
  counsel the matter has been settled by controlling precedent, submit
  to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the
  Securities Act and will be governed by the final adjudication of
  such issue.
  4
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of New York, State of New York, on this 11th day of
  June, 2003.
  ANTIGENICS INC.
  By:
  /s/ Garo H. Armen, Ph.D.
  Name:
  Garo H. Armen, Ph.D.
  Title:
  Chief Executive Officer and Chairman
  of the Board
  POWER OF ATTORNEY
  Each person whose signature appears below constitutes and appoints Garo
  Armen and Jeffrey Clark, and each of them singly, his or her true and lawful
  attorney-in-fact and agent with full power of substitution and resubstitution,
  for him or her and in his or her name, place and stead, in any and all
  capacities, to sign any and all amendments (including post-effective
  amendments) to this Registration Statement on Form S-8 to be filed by
  Antigenics Inc., and to file the same, with all exhibits thereto, and other
  documents in connection therewith, with the Securities and Exchange Commission,
  granting unto said attorneys-in-fact and agents full power and authority to be
  done in and about the premises, as fully to all intents and purposes as he or
  she might or could do in person, hereby ratifying and confirming all that said
  attorneys-in-fact and agents, or their substitutes, may lawfully do or cause to
  be done by virtue hereof.
  * * * *
  Pursuant to the requirements of the Securities Act of 1933, as amended,
  this Registration Statement has been signed by the following persons in the
  capacities indicated as of June 11, 2003.
  Signature
  Title
  /s/ Garo H. Armen, Ph.D.
  Garo H. Armen, Ph.D.
  Chief Executive Officer and Chairman of
  the Board of Directors
  (Principal Executive Officer)
  /s/ Jeff D. Clark
  Jeff D. Clark
  Chief Financial Officer
  (Principal Financial Officer
  and Principal Accounting Officer)
  /s/ Noubar Afeyan, Ph.D.
  Noubar Afeyan, Ph.D
  Director
  Table of Contents
  /s/ Frank AtLee
  Frank AtLee
  Director
  /s/ Gamil de Chadarevian
  Gamil de Chadarevian
  Director, Vice Chairman of the Board
  /s/ Tom Dechaene
  Tom Dechaene
  Director
  /s/ Margaret Eisen
  Margaret Eisen
  Director
  /s/ Wadih Jordan
  Wadih Jordan
  Director
  /s/ Mark Kessel
  Mark Kessel
  Director
  /s/ Pramod Srivastava
  Pramod Srivastava
  Director
  Table of Contents
  EXHIBIT INDEX
  4.1
  Antigenics Inc. Directors' Deferred Compensation Plan.
  4.2
  Amended and Restated Certificate of Incorporation of Antigenics Inc.
  (previously filed as Exhibit 3.1 to the Current Report on Form 8-K dated
  June 10, 2002, File No. 000-29089).
  4.3
  Amended and Restated By-laws of Antigenics Inc. (previously filed as
  Exhibit 3.2 to the Current Report on Form 8-K dated June 10, 2002, File
  No. 000-29089).
  5.1
  Opinion of Ropes & Gray LLP.
  23.1
  Consent of KPMG LLP.
  23.2
  Consent of Ropes & Gray LLP (included in the opinion filed as Exhibit 5.1).
  24.1
  Powers of Attorney (included on the signature page in Part II).