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  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">As filed with the Securities and Exchange Commission on February&nbsp;9, 2009<BR>
  Registration No.&nbsp;333-<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT UNDER<BR>
  THE SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>ALKERMES, INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact Name of Company as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="48%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="48%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Pennsylvania</B><BR>
  (State or other jurisdiction of incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>23-2472830</B><BR>
  (I.R.S. Employer Identification No.)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>ALKERMES, INC.<BR>
  88 SIDNEY STREET<BR>
  CAMBRIDGE, MASSACHUSETTS 02139-4234</B><BR>
  (Address, including zip code of registrant&#146;s principal executive offices)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>ALKERMES, INC. 2002 RESTRICTED STOCK AWARD PLAN</B><BR>
  (Full title of the plan)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">David A. Broecker<BR>
  Chief Executive Officer<BR>
  ALKERMES, INC.<BR>
  88 Sidney Street<BR>
  Cambridge, Massachusetts 02139-4234<BR>
  Telephone: (617)&nbsp;494-0171<BR>
  (Name, address, including zip code, and telephone number, including area code, of agent for service)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">Copies to:</DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top">Mitchell S. Bloom, Esq.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Kathryn L. Biberstein, Esq.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Robert E. Puopolo, Esq.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Alkermes, Inc.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Goodwin Procter LLP
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">88 Sidney Street</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">53 State Street
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Cambridge, MA 02139</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Boston, MA 02109
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Telephone: (617)&nbsp;583-6255</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Telephone: (617)&nbsp;570-1000</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="justify" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated
  filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &#147;large
  accelerated filer,&#148; &#147;accelerated filer&#148; and &#147;smaller reporting company&#148; in Rule&nbsp;12b-2 of the
  Exchange Act. (Check one):
  </DIV>
  
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="22%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="left" valign="top">Large accelerated filer <FONT face="Wingdings">&#254;</FONT>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Accelerated filer <FONT face="Wingdings">&#111;</FONT>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Non-accelerated filer <FONT face="Wingdings">&#111;</FONT>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" nowrap>Smaller reporting company <FONT face="Wingdings">&#111;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" nowrap>(Do not check if a smaller reporting company)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>CALCULATION OF REGISTRATION FEE</B></DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="57%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="6%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="6%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Offering Price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Aggregate Offering</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of Securities</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Registered (2)</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Per Share</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Registration Fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value $0.01 per share(1)</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">510,476</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">11.04       </TD>
      <TD nowrap style="border-top: 2px solid #000000">(3)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">5,635,656</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">222</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 3pt; width: 18%; border-top: 0px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>This Registration Statement also relates to the Rights to purchase shares of Series&nbsp;A Junior Participating Preferred Stock of the Registrant
  which are attached to all shares of Common Stock pursuant to the terms of the Registrant&#146;s Rights Agreement dated February&nbsp;7, 2003. Until
  the occurrence of certain prescribed events, the Rights are not exercisable, are evidenced by the certificates for the Common Stock and will
  be transferred only with such stock.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Pursuant to Rule 416(c) under the Securities Act of 1933, this registration statement shall also be deemed to cover an indeterminate number
  of additional shares of Common Stock issuable in the event the number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend, recapitalization, and certain other capital adjustments and the like.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of calculating the registration fee. In accordance with Rules 457(c) and 457(h), the proposed maximum
  offering price per share, the proposed maximum aggregate offering price, and the registration fee shown has been computed based upon the
  average of the high and low sales price of the Company&#146;s Common Stock on February&nbsp;6, 2009, $11.04, as reported on the Nasdaq Global Market
  with respect to securities for which options have not been granted.</TD>
  </TR>
  
  
  
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link1 "PART I" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">This Registration Statement on Form S-8 registers 510,476 shares of common stock, par value $0.01
  per share (the &#147;Common Stock&#148;), of Alkermes, Inc. (the &#147;Registrant&#148;) which may be acquired pursuant
  to the Alkermes, Inc. 2002 Restricted Stock Award Plan, as amended (the &#147;Plan&#148;). The securities
  subject to this Registration Statement are of the same class of the Registrant for which the
  Registrant previously filed Registration Statements on Form S-8 under the Securities Act of 1933,
  as amended (the &#147;Securities Act&#148;) (Registration Nos. 333-137549 and 333-107208 registering 800,000
  shares of Common Stock). Accordingly, the contents of the Registrant&#146;s Registration Statement on
  Form S-8, Registration Nos. 333-107208 and 333-137549, as filed with the Securities and Exchange
  Commission are hereby incorporated by reference pursuant to General Instruction E to Form S-8.
  After giving effect to this Registration Statement, an aggregate of 1,310,476 shares of the
  Registrant&#146;s Common Stock have been registered for issuance pursuant to the Plan.
  </DIV>
  
  <!-- link1 "PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II<BR>
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  </DIV>
  
  <!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;3. <U>Incorporation of Documents by Reference</U>.
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Annual Report on Form 10-K for the
  fiscal year ended March&nbsp;31, 2008 filed with the
  Commission on May&nbsp;30, 2008;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Quarterly Report on Form 10-Q for the
  three months ended June&nbsp;30, 2008 filed with the
  Commission on August&nbsp;7, 2008;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Quarterly Report on Form 10-Q for the
  three months ended September&nbsp;30, 2008 filed with the
  Commission on November&nbsp;7, 2008;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Quarterly Report on Form 10-Q for the
  three months ended December&nbsp;31, 2008 filed with the
  Commission on February&nbsp;9, 2009;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Reports on Forms 8-K filed
  with the Commission on May&nbsp;16, 2008; May&nbsp;28, 2008;
  June&nbsp;16, 2008 (<I>Item&nbsp;8.01 only</I>); October&nbsp;7, 2008;
  November&nbsp;4, 2008; and December&nbsp;1, 2008 (<I>Item&nbsp;1.02
  only</I>).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>All other documents filed by the Company pursuant to 13(a) or 15(d) of
  the Exchange Act since the end of the fiscal year covered by the
  document referred to in (a)&nbsp;above; and</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Item&nbsp;1 of Registration Statement of the Company on Form 8-A dated June
  28, 1991, as amended by a Registration Statement of the Company on
  Form 8-A/A dated January&nbsp;17, 1997; and Item&nbsp;1 of Registration
  Statement of the Company on Form 8-A dated May&nbsp;2, 2003.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14 or 15(d) of the Exchange
  Act, after the date of this Registration Statement and prior to the filing of a post-effective
  amendment which indicates that all securities offered herein have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing such documents. Any statement contained herein or in a
  document incorporated by reference or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document which is incorporated
  or is deemed to be incorporated by reference herein. Any such statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this Registration
  Statement.
  </DIV>
  
  <!-- link2 "Item&nbsp;4. Description of Securities" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;4. <U>Description of Securities</U>.
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Not applicable.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <!-- link2 "Item&nbsp;5.Interests of Named Experts and Counsel" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;5. <U>Interests of Named Experts and Counsel</U>.
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Not applicable.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;8. <U>Exhibits.</U>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;See the Exhibit&nbsp;Index on the page immediately preceding the exhibits for a list of exhibits
  filed as part of this Registration Statement on Form S-8, which Exhibit&nbsp;Index is incorporated
  herein by reference.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "SIGNATURES" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, the Company certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Cambridge, in the Commonwealth of Massachusetts, on this 9th day of
  February&nbsp;2009.
  </DIV>
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">
  
  ALKERMES, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">
  
  /s/ David A. Broecker
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">David A. Broecker&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>POWER OF ATTORNEY AND SIGNATURES</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been
  signed below by the following persons in the capacities and on the dates indicated.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Each person whose signature appears below in so signing also makes, constitutes and appoints David
  A. Broecker and James M. Frates, and each of them, his true and lawful attorney-in-fact, with full
  power of substitution, for him in any and all capacities, to execute and cause to be filed with the
  Securities and Exchange Commission any and all amendments and post-effective amendments to this
  Registration Statement, with exhibits thereto and other documents in connection therewith, and
  hereby ratifies and confirms all that said attorney-in-fact or his substitute or substitutes may do
  or cause to be done by virtue hereof.
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>SIGNATURE</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>TITLE</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>DATE</B></TD>
  </TR>
  <TR valign="top"><!-- Blank Space -->
   <TD><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD></TR>
  
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" nowrap valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Richard F. Pops
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Richard F. Pops</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director and Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ David A. Broecker
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  David A. Broecker</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  President and Chief Executive Officer
  (Principal Executive Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ James M. Frates
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  James M. Frates</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Senior Vice President, Chief Financial
  Officer and Treasurer
  (Principal Financial and Accounting Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ David W. Anstice
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  David W. Anstice</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Floyd E. Bloom
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Floyd E. Bloom</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Robert A. Breyer
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Robert A. Breyer</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Gerri Henwood
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Gerri Henwood</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Paul J. Mitchell
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Paul J. Mitchell</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Alexander Rich
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Alexander Rich</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Mark B. Skaletsky
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Mark B. Skaletsky</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Michael A. Wall
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Michael A. Wall</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director and Chairman Emeritus
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February 9, 2009</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "INDEX TO EXHIBITS" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX TO EXHIBITS</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="11%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="84%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit No.</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000">Description of Exhibit</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Third Amended and Restated Articles of Incorporation as filed with the
  Pennsylvania Secretary of State on June&nbsp;7, 2001. (Incorporated by reference
  to Exhibit&nbsp;3.1 to the Registrant&#146;s Report on Form&nbsp;10-K for the fiscal year
  ended March&nbsp;31, 2001 (File No.&nbsp;001-14131).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amendment to Third Amended and Restated Articles of Incorporation as filed
  with the Pennsylvania Secretary of State on December&nbsp;16, 2002 (2002
  Preferred Stock Terms). (Incorporated by reference to Exhibit&nbsp;3.1 to the
  Registrant&#146;s Current Report on Form&nbsp;8-K filed on December&nbsp;16, 2002 (File
  No.&nbsp;001-14131).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amendment to Third Amended and Restated Articles of Incorporation as filed
  with the Pennsylvania Secretary of State on May&nbsp;14, 2003 (Incorporated by
  reference to Exhibit&nbsp;A to Exhibit&nbsp;4.1 to the Registrant&#146;s Report on Form
  8-A filed on May&nbsp;2, 2003 (File No.&nbsp;000-19267).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Second Amended and Restated By-Laws of Alkermes, Inc. (Incorporated by
  reference to Exhibit&nbsp;3.2 to the Registrant&#146;s Current Report on Form&nbsp;8-K
  filed on September&nbsp;28, 2005.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by
  reference to Exhibit&nbsp;4 to the Registrant&#146;s Registration Statement on Form
  S-1, as amended (File No.&nbsp;033-40250).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.6
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, dated as of February&nbsp;7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Report on
  Form&nbsp;8-A filed on May&nbsp;2, 2003 (File No.&nbsp;000-19267).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Ballard Spahr Andrews &#038; Ingersoll, LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ballard Spahr Andrews &#038; Ingersoll, LLP (included in Exhibit&nbsp;5.1).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included in signature page).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Alkermes, Inc. 2002 Restricted Stock Award Plan as Amended and Approved on
  November&nbsp;2, 2006. (Incorporated by reference to Exhibit&nbsp;10.3 to the
  Registrant&#146;s Report on Form&nbsp;10-Q for the fiscal quarter ended December&nbsp;31,
  2006.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amendment to Alkermes, Inc. 2002 Restricted Stock Award Plan. (Incorporated
  by reference to Appendix&nbsp;B to the Registrant&#146;s Definitive Proxy Statement
  on Form&nbsp;DEF 14/A filed on July&nbsp;27, 2007.)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  
  
  </BODY>
  </HTML>
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metadata_filer: {"company-data": {"conformed-name": "ALKERMES INC", "cik": "0000874663", "assigned-sic": "2834", "irs-number": "232472830", "state-of-incorporation": "PA", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-157195", "film-number": "09581868"}, "business-address": {"street1": "88 SIDNEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02139-4136", "phone": "617-494-0171"}}
text: sv8
  As filed with the Securities and Exchange Commission on February 9, 2009
  Registration No. 333-
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER
  THE SECURITIES ACT OF 1933
  ALKERMES, INC.
  (Exact Name of Company as specified in its charter)
  Pennsylvania
  (State or other jurisdiction of incorporation or organization)
  23-2472830
  (I.R.S. Employer Identification No.)
  ALKERMES, INC.
  88 SIDNEY STREET
  CAMBRIDGE, MASSACHUSETTS 02139-4234
  (Address, including zip code of registrant's principal executive offices)
  ALKERMES, INC. 2002 RESTRICTED STOCK AWARD PLAN
  (Full title of the plan)
  David A. Broecker
  Chief Executive Officer
  ALKERMES, INC.
  88 Sidney Street
  Cambridge, Massachusetts 02139-4234
  Telephone: (617) 494-0171
  (Name, address, including zip code, and telephone number, including area code, of agent for service)
  Copies to:
  Mitchell S. Bloom, Esq.
  Kathryn L. Biberstein, Esq.
  Robert E. Puopolo, Esq.
  Alkermes, Inc.
  Goodwin Procter LLP
  88 Sidney Street
  53 State Street
  Cambridge, MA 02139
  Boston, MA 02109
  Telephone: (617) 583-6255
  Telephone: (617) 570-1000
  Indicate by check mark whether the registrant is a large accelerated filer, an accelerated
  filer, a non-accelerated filer, or a smaller reporting company. See the definitions of "large
  accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the
  Exchange Act. (Check one):
  Large accelerated filer
  þ
  Accelerated filer
  o
  Non-accelerated filer
  o
  Smaller reporting company
  o
  (Do not check if a smaller reporting company)
  CALCULATION OF REGISTRATION FEE
  Proposed
  Maximum
  Proposed Maximum
  Amount to be
  Offering Price
  Aggregate Offering
  Amount of
  Title of Securities
  Registered (2)
  Per Share
  Price
  Registration Fee
  Common Stock, par value $0.01 per share(1)
  510,476
  $
  11.04
  (3)
  $
  5,635,656
  $
  222
  (1)
  This Registration Statement also relates to the Rights to purchase shares of Series A Junior Participating Preferred Stock of the Registrant
  which are attached to all shares of Common Stock pursuant to the terms of the Registrant's Rights Agreement dated February 7, 2003. Until
  the occurrence of certain prescribed events, the Rights are not exercisable, are evidenced by the certificates for the Common Stock and will
  be transferred only with such stock.
  (2)
  Pursuant to Rule 416(c) under the Securities Act of 1933, this registration statement shall also be deemed to cover an indeterminate number
  of additional shares of Common Stock issuable in the event the number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend, recapitalization, and certain other capital adjustments and the like.
  (3)
  Estimated solely for the purpose of calculating the registration fee. In accordance with Rules 457(c) and 457(h), the proposed maximum
  offering price per share, the proposed maximum aggregate offering price, and the registration fee shown has been computed based upon the
  average of the high and low sales price of the Company's Common Stock on February 6, 2009, $11.04, as reported on the Nasdaq Global Market
  with respect to securities for which options have not been granted.
  PART I
  This Registration Statement on Form S-8 registers 510,476 shares of common stock, par value $0.01
  per share (the "Common Stock"), of Alkermes, Inc. (the "Registrant") which may be acquired pursuant
  to the Alkermes, Inc. 2002 Restricted Stock Award Plan, as amended (the "Plan"). The securities
  subject to this Registration Statement are of the same class of the Registrant for which the
  Registrant previously filed Registration Statements on Form S-8 under the Securities Act of 1933,
  as amended (the "Securities Act") (Registration Nos. 333-137549 and 333-107208 registering 800,000
  shares of Common Stock). Accordingly, the contents of the Registrant's Registration Statement on
  Form S-8, Registration Nos. 333-107208 and 333-137549, as filed with the Securities and Exchange
  Commission are hereby incorporated by reference pursuant to General Instruction E to Form S-8.
  After giving effect to this Registration Statement, an aggregate of 1,310,476 shares of the
  Registrant's Common Stock have been registered for issuance pursuant to the Plan.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference
  .
  (a)
  The Registrant's Annual Report on Form 10-K for the
  fiscal year ended March 31, 2008 filed with the
  Commission on May 30, 2008;
  The Registrant's Quarterly Report on Form 10-Q for the
  three months ended June 30, 2008 filed with the
  Commission on August 7, 2008;
  The Registrant's Quarterly Report on Form 10-Q for the
  three months ended September 30, 2008 filed with the
  Commission on November 7, 2008;
  The Registrant's Quarterly Report on Form 10-Q for the
  three months ended December 31, 2008 filed with the
  Commission on February 9, 2009;
  The Registrant's Current Reports on Forms 8-K filed
  with the Commission on May 16, 2008; May 28, 2008;
  June 16, 2008 (
  Item 8.01 only
  ); October 7, 2008;
  November 4, 2008; and December 1, 2008 (
  Item 1.02
  only
  ).
  (b)
  All other documents filed by the Company pursuant to 13(a) or 15(d) of
  the Exchange Act since the end of the fiscal year covered by the
  document referred to in (a) above; and
  (c)
  Item 1 of Registration Statement of the Company on Form 8-A dated June
  28, 1991, as amended by a Registration Statement of the Company on
  Form 8-A/A dated January 17, 1997; and Item 1 of Registration
  Statement of the Company on Form 8-A dated May 2, 2003.
  All documents filed by the Company pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange
  Act, after the date of this Registration Statement and prior to the filing of a post-effective
  amendment which indicates that all securities offered herein have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing such documents. Any statement contained herein or in a
  document incorporated by reference or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document which is incorporated
  or is deemed to be incorporated by reference herein. Any such statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this Registration
  Statement.
  Item 4.
  Description of Securities
  .
  Not applicable.
  Item 5.
  Interests of Named Experts and Counsel
  .
  Not applicable.
  Item 8.
  Exhibits.
  See the Exhibit Index on the page immediately preceding the exhibits for a list of exhibits
  filed as part of this Registration Statement on Form S-8, which Exhibit Index is incorporated
  herein by reference.
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Company certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Cambridge, in the Commonwealth of Massachusetts, on this 9th day of
  February 2009.
  ALKERMES, INC.
  By:
  /s/ David A. Broecker
  David A. Broecker
  Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been
  signed below by the following persons in the capacities and on the dates indicated.
  Each person whose signature appears below in so signing also makes, constitutes and appoints David
  A. Broecker and James M. Frates, and each of them, his true and lawful attorney-in-fact, with full
  power of substitution, for him in any and all capacities, to execute and cause to be filed with the
  Securities and Exchange Commission any and all amendments and post-effective amendments to this
  Registration Statement, with exhibits thereto and other documents in connection therewith, and
  hereby ratifies and confirms all that said attorney-in-fact or his substitute or substitutes may do
  or cause to be done by virtue hereof.
  SIGNATURE
  TITLE
  DATE
  /s/ Richard F. Pops
  Richard F. Pops
  Director and Chairman of the Board
  February 9, 2009
  /s/ David A. Broecker
  David A. Broecker
  President and Chief Executive Officer
  (Principal Executive Officer)
  February 9, 2009
  /s/ James M. Frates
  James M. Frates
  Senior Vice President, Chief Financial
  Officer and Treasurer
  (Principal Financial and Accounting Officer)
  February 9, 2009
  /s/ David W. Anstice
  David W. Anstice
  Director
  February 9, 2009
  /s/ Floyd E. Bloom
  Floyd E. Bloom
  Director
  February 9, 2009
  /s/ Robert A. Breyer
  Robert A. Breyer
  Director
  February 9, 2009
  /s/ Gerri Henwood
  Gerri Henwood
  Director
  February 9, 2009
  /s/ Paul J. Mitchell
  Paul J. Mitchell
  Director
  February 9, 2009
  /s/ Alexander Rich
  Alexander Rich
  Director
  February 9, 2009
  /s/ Mark B. Skaletsky
  Mark B. Skaletsky
  Director
  February 9, 2009
  /s/ Michael A. Wall
  Michael A. Wall
  Director and Chairman Emeritus
  February 9, 2009
  INDEX TO EXHIBITS
  Exhibit No.
  Description of Exhibit
  4.1
  Third Amended and Restated Articles of Incorporation as filed with the
  Pennsylvania Secretary of State on June 7, 2001. (Incorporated by reference
  to Exhibit 3.1 to the Registrant's Report on Form 10-K for the fiscal year
  ended March 31, 2001 (File No. 001-14131).)
  4.2
  Amendment to Third Amended and Restated Articles of Incorporation as filed
  with the Pennsylvania Secretary of State on December 16, 2002 (2002
  Preferred Stock Terms). (Incorporated by reference to Exhibit 3.1 to the
  Registrant's Current Report on Form 8-K filed on December 16, 2002 (File
  No. 001-14131).)
  4.3
  Amendment to Third Amended and Restated Articles of Incorporation as filed
  with the Pennsylvania Secretary of State on May 14, 2003 (Incorporated by
  reference to Exhibit A to Exhibit 4.1 to the Registrant's Report on Form
  8-A filed on May 2, 2003 (File No. 000-19267).)
  4.4
  Second Amended and Restated By-Laws of Alkermes, Inc. (Incorporated by
  reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K
  filed on September 28, 2005.)
  4.5
  Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by
  reference to Exhibit 4 to the Registrant's Registration Statement on Form
  S-1, as amended (File No. 033-40250).)
  4.6
  Rights Agreement, dated as of February 7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's Report on
  Form 8-A filed on May 2, 2003 (File No. 000-19267).)
  5.1
  Opinion of Ballard Spahr Andrews & Ingersoll, LLP (filed herewith).
  23.1
  Consent of Ballard Spahr Andrews & Ingersoll, LLP (included in Exhibit 5.1).
  23.2
  Consent of PricewaterhouseCoopers LLP (filed herewith).
  23.3
  Consent of Deloitte & Touche LLP (filed herewith).
  24.1
  Power of Attorney (included in signature page).
  99.1
  Alkermes, Inc. 2002 Restricted Stock Award Plan as Amended and Approved on
  November 2, 2006. (Incorporated by reference to Exhibit 10.3 to the
  Registrant's Report on Form 10-Q for the fiscal quarter ended December 31,
  2006.)
  99.2
  Amendment to Alkermes, Inc. 2002 Restricted Stock Award Plan. (Incorporated
  by reference to Appendix B to the Registrant's Definitive Proxy Statement
  on Form DEF 14/A filed on July 27, 2007.)