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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center" style="font-size: 10pt; margin-top: 2pt">As filed with the Securities and Exchange Commission on May&nbsp;29, 2009</DIV>
  
  <DIV align="right" style="font-size: 10pt; margin-top: 6pt">REGISTRATION NO. 333 -&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</DIV>
  <DIV style="margin-top: 3pt; width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV align="center" style="font-size: 14pt; margin-top: 11pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B></DIV>
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B></DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 11pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  <DIV align="center" style="font-size: 18pt; margin-top: 11pt"><B>FORM S-8</B></DIV>
  
  <DIV align="center" style="font-size: 12pt; margin-top: 11pt"><B>REGISTRATION STATEMENT<BR>
  under the<BR>
  SECURITIES ACT OF 1933</B></DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 11pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  <DIV align="center" style="font-size: 24pt; margin-top: 11pt"><B>OXiGENE, INC.</B></DIV>
  <DIV align="center" style="font-size: 10pt">(<I>Exact Name of Registrant as Specified in Its Charter)</I></DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B><BR>
  (<I>State or Other Jurisdiction <BR>
  of Incorporation or Organization</I>)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>13-3679168</B><BR>
  (<I>I.R.S. Employer<BR>
  Identification No.</I>)</TD>
  </TR>
  </TABLE></DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 11pt"><B>230 Third Avenue<BR>
  Waltham, MA 02451</B><BR>
  (<I>Address, Including Zip Code, of Principal Executive Offices</I>)</DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 11pt"><B>OXiGENE, INC. 2005 STOCK PLAN<BR>
  OXiGENE, INC. 2009 EMPLOYEE STOCK PURCHASE PLAN</B><BR>
  <I>(Full Titles of the Plans)</I></DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 11pt"><B>John A. Kollins<BR>
  Chief Executive Officer<BR>
  OXiGENE, Inc.<BR>
  230 Third Avenue<BR>
  Waltham, MA 02451<BR>
  781-547-5900</B><BR>
  (<I>Name, Address and Telephone Number, Including<BR>
  Area Code, of Agent For Service</I>)</DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 11pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Indicate by check mark whether the registrant is a large
   accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
   of &#147;large accelerated filer,&#148; &#147;accelerated filer&#148; and &#147;smaller reporting
   company&#148; in Rule&nbsp;12b-2 of the
   Exchange Act. (Check one):</DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="22%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Large accelerated filer <FONT face="Wingdings">&#111;</FONT></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Accelerated filer <FONT face="Wingdings">&#111;</FONT></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Non-accelerated filer <FONT face="Wingdings">&#111;</FONT></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" nowrap>Smaller reporting company <FONT face="Wingdings">&#254;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" nowrap>(Do not check if a smaller reporting company)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  </TABLE></DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>CALCULATION OF REGISTRATION FEE</B></DIV>
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
      <TD nowrap align="center">Title of</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Offering Price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Aggregate</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #ffffff">Securities to be Registered</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3" style="border-bottom: 1px solid #ffffff">Registered<SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Per Share<SUP style="font-size: 85%; vertical-align: text-top"> (2)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Offering Price<SUP style="font-size: 85%; vertical-align: text-top"> (2)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3" style="border-bottom: 1px solid #ffffff">Registration Fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, $0.01 par value</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">7,000,000</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">2.04</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">14,280,000</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">796.82</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Rights to purchase Common Stock</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">(3</TD>
      <TD nowrap style="border-top: 2px solid #000000">)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">(3</TD>
      <TD nowrap style="border-top: 2px solid #000000">)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">(3</TD>
      <TD nowrap style="border-top: 2px solid #000000">)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD colspan="3" nowrap align="center" style="border-top: 2px solid #000000">None</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  </TABLE></DIV>
  
  <DIV style="font-size: 1pt; margin-top: 3pt; width: 18%; border-top: 0px solid #000000">&nbsp;</DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>The number of shares of common stock, par value $0.01 per share (&#147;Common Stock&#148;) of OXiGENE,
  Inc. (the &#147;Registrant&#148;), stated above consists of the aggregate number of shares which may be
  sold (i)&nbsp;upon the exercise of options or issuance of stock awards which may hereafter be
  granted under the OXiGENE, Inc. 2005 Stock Plan (the &#147;Stock Plan&#148;) and (ii)&nbsp;under the OXiGENE,
  Inc. 2009 Employee Stock Purchase Plan (the &#147;Purchase Plan&#148; and together with the Stock Plan,
  the &#147;Plans&#148;). The maximum number of shares which may be sold upon the exercise of such
  options or issuance of stock awards granted under the Plans are subject to adjustment in
  accordance with certain anti-dilution and other provisions of the Plans. Accordingly,
  pursuant to Rule&nbsp;416 under the Securities Act of 1933, as amended (the &#147;Securities Act&#148;), this
  Registration Statement covers, in addition to the number of shares stated above, an
  indeterminate number of shares which may be subject to grant or otherwise issuable after the
  operation of any such anti-dilution and other provisions.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(c) and (h)&nbsp;under the Securities Act on the basis of the average
  of the high and low sale prices per share of the Common Stock on the NASDAQ Global Market as
  of a date (May&nbsp;26, 2009) within five business days prior to filing this Registration Statement.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>No separate consideration will be received for the Rights.</TD>
  </TR>
  </TABLE>
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 8pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U>EXPLANATORY NOTE</U>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with the instructional Note to Part&nbsp;I of Form S-8 as promulgated by the
  Securities and Exchange Commission, the information specified by Part&nbsp;I of Form S-8 has been
  omitted from this Registration Statement on Form S-8 for offers of Common Stock pursuant to the
  Plans.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B><I>Stock Plan</I></B><I>. </I>This Registration Statement on Form S-8 hereby registers 5,000,000 additional
  shares of Common Stock for issuance under the Stock Plan, as approved at the Annual Meeting of
  Stockholders held on May&nbsp;28, 2009. On July&nbsp;15, 2005, the Registrant filed a registration statement
  on Form S-8 (File No.&nbsp;333-126636) to register 2,500,000 shares of Common Stock reserved for
  issuance under the Stock Plan.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B><I>Purchase Plan. </I></B>This Registration Statement on Form S-8 hereby registers 2,000,000 shares of
  Common Stock under the Purchase Plan, as approved at the Annual Meeting of Stockholders held on May
  28, 2009.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Certain Documents by Reference</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;4. Description of Securities</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;7. Exemption from Registration Claimed</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;8. Exhibits</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;9. Undertakings</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#008">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b75681oiexv5.htm">Ex-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares being registered</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b75681oiexv23w2.htm">Ex-23.2 Consent of Ernst & Young LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link1 "PART II" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  </DIV>
  <!-- link2 "Item&nbsp;3. Incorporation of Certain Documents by Reference" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;3. Incorporation of Certain Documents by Reference</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31, 2008
  filed on March&nbsp;30, 2009 (File No.&nbsp;000-21990).
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;The Registrant&#146;s Quarterly Report on Form 10-Q for the quarter ended March&nbsp;31, 2009 filed
  on May&nbsp;15, 2009 (File No.&nbsp;000-21990).
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;The Registrant&#146;s Current Report on Form 8-K filed on January&nbsp;9, 2009 (File No.&nbsp;000-21990).
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;The Registrant&#146;s Current Report on Form 8-K filed on March&nbsp;25, 2009 (File No.&nbsp;000-21990).
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;The Registrant&#146;s Current Report on Form 8-K filed on May&nbsp;4, 2009 (File No.&nbsp;000-21990).
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;The description of the Common Stock contained in the Registrant&#146;s Registration Statement
  on Form 8-A (File No.&nbsp;000-21990) filed under the Exchange Act, with the Commission on June&nbsp;25,
  1993, including any amendment or report filed for the purpose of updating such description.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)&nbsp;The description of the Rights under the Stockholder Rights Agreement (which are currently
  transferred with the Registrant&#146;s Common Stock) contained in the Registrant&#146;s Registration
  Statement on Form 8-A12G (File No.&nbsp;000-21990) filed under the Exchange Act with the Commission on
  March&nbsp;30, 2005, including any amendment or report filed for the purpose of updating such
  description.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective
  amendment which indicates that all securities offered hereby have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such reports and documents.
  </DIV>
  <!-- link2 "Item&nbsp;4. Description of Securities" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;4. Description of Securities</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;5. Interests of Named Experts and Counsel</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C., and members of that firm, their families and trusts for their benefit own an aggregate of
  approximately 350 shares of Common Stock of the Registrant.
  </DIV>
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;6. Indemnification of Directors and Officers</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporated by reference from the Registrant&#146;s Registration Statement on Form S-3, filed on
  November&nbsp;14, 2008 (File No.&nbsp;333-155372).
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->1<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link2 "Item&nbsp;7. Exemption from Registration Claimed" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <DIV style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;7. Exemption from Registration Claimed</U>.</DIV>
  
  <DIV style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</DIV>
  
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <DIV style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;8. Exhibits</U>.</DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(4.1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Restated Certificate of Incorporation of the Registrant (Filed as Exhibit to
  the Registrant&#146;s Registration Statement on Form S-1, as amended (File No.&nbsp;033-64968),
  and incorporated herein by reference).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(4.2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Certificates of Amendment of Restated Certificate of Incorporation of the
  Registrant dated June&nbsp;21, 2995 and November&nbsp;15, 1996 (Filed as Exhibits to the
  Registrant&#146;s Annual Report of Form 10-K for the fiscal year ended December&nbsp;31, 1996
  (File No.&nbsp;000-21990), and incorporated herein by reference).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(4.3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Certificate of Amendment of Restated Certificate of Incorporation of the
  Registrant, dated July&nbsp;14, 2005 (Filed as Exhibit to the Registrant&#146;s Registration
  Statement on Form S-8 (File No.&nbsp;333-126636), and incorporated herein by reference).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(4.4)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Amended and Restated By-Laws of the Registrant (Filed as Exhibit to the
  Registrant&#146;s Quarterly Report on Form 8-K, filed on December&nbsp;20, 2007 (File No.
  000-21990), and incorporated herein by reference).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(4.5)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Form of Common Stock Certificate (Filed as Exhibit to the Registrant&#146;s
  Registration Statement on Form S-1, as amended (File No.&nbsp;033-64968), and incorporated
  herein by reference).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(4.6)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Stockholder Rights Agreement (Filed as Exhibit to the Registrant&#146;s
  Registration Statement on Form 8-A, dated March&nbsp;30, 2005 (File No.&nbsp;000-21990), and
  incorporated herein by reference).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(5)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the
  legality of shares being registered.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(23.1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion
  of counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(23.2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Consent of Ernst &#038; Young LLP.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(24)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Power of Attorney to file future amendments (set forth on the signature page of
  this Registration Statement).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap>(99.1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>OXiGENE, Inc. 2005 Stock Plan, as amended (Filed as Appendix&nbsp;B to the Registrant&#146;s
  Definitive Proxy Statement on Schedule&nbsp;14A, filed on April&nbsp;7, 2009 (File No.
  000-21990), and incorporated herein by reference).</TD>
  </TR>
  
  </TABLE></DIV>
  <P align="center" style="font-size: 10pt"><!-- Folio -->2<!-- /Folio --></DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(99.2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>OXiGENE, Inc. 2009 Employee Stock Purchase Plan (Filed as Appendix&nbsp;C to the
  Registrant&#146;s Definitive Proxy Statement on Schedule&nbsp;14A, filed on April&nbsp;7, 2009 (File
  No.&nbsp;000-21990), and incorporated herein by reference).</TD>
  </TR>
  </TABLE></DIV>
  <!-- link2 "Item&nbsp;9. Undertakings" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;9. Undertakings</U>.</DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes:</TD>
  </TR>
  </TABLE></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">(1)&nbsp;To file, during any period in which offers or sales are being made, a post-effective
  amendment to this Registration Statement:</DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of the Securities
  Act of 1933;</DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental
  change in the information set forth in the Registration Statement. Notwithstanding
  the foregoing, any increase or decrease in volume of securities offered (if the
  total dollar value of securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated maximum offering range
  may be reflected in the form of prospectus filed with the Commission pursuant to
  Rule 424(b) if, in the aggregate, the changes in volume and price represent no more
  than a 20% change in the maximum aggregate offering price set forth in the
  &#147;Calculation of Registration Fee&#148; table in the effective Registration Statement.</DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or any material
  change to such information in the Registration Statement;</DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however</I>, that Paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  registration statement is on Form S-8, Form S-3 or Form F-3, and the information required to
  be included in a post-effective amendment by those paragraphs is contained in reports filed
  with or furnished to the Commission by the Registrant pursuant to Section&nbsp;13 or Section
  15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the
  Registration Statement.</DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">(2)&nbsp;That, for the purpose of determining any liability under the Securities Act of 1933,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.</DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">(3)&nbsp;To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.</DIV>
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant&#146;s annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by
  reference in this Registration Statement shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.</TD>
  </TR>
  </TABLE></DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->3<!-- /Folio --></DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed
  in the Act and is, therefore, unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense
  of any action, suit or proceeding) is asserted by such director, officer or controlling person
  in connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <P align="center" style="font-size: 10pt"><!-- Folio -->4<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>The Registrant</I>. Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
  the undersigned, thereunto duly authorized, in the City of Waltham, Massachusetts on May&nbsp;29, 2009.</DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="52%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="31%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left"><FONT style="font-variant: SMALL-CAPS"><B>OX</B></FONT><B>i</B><FONT style="font-variant: SMALL-CAPS"><B>GENE, INC.</B></FONT><BR>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ John A. Kollins&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left"><B>John A. Kollins</B>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left"><B>Chief Executive Officer</B>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints John A. Kollins and James
  B. Murphy, and each of them singly, his true and lawful attorneys-in-fact and agents, with full
  power of substitution and resubstitution in each of them singly, for him and in his name, place and
  stead, and in any and all capacities, to sign any and all amendments (including post-effective
  amendments) to this Registration Statement on Form S-8 of OXiGENE, Inc., and to file the same, with
  all exhibits thereto and other documents in connection therewith, with the Securities and Exchange
  Commission, granting to the attorneys-in-fact and agents, and each of them, full power and
  authority to do and perform each and every act and thing requisite or necessary to be done in or
  about the premises, as full to all intents and purposes as he might or could do in person, hereby
  ratifying and confirming all that the attorneys-in-fact and agents or any of each of them or their
  substitute may lawfully do or cause to be done by virtue hereof.</DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.</DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="28%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="45%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="25%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ John A. Kollins
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  John A. Kollins</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Chief Executive Officer and Director<BR>
  
  (Principal executive officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;29, 2009</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ James B. Murphy
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  James B. Murphy</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Vice President and Chief Financial Officer<BR>
  
  (Principal financial officer and <BR>
  
  principal accounting officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;29, 2009</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ William N. Shiebler
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  William N. Shiebler</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Chairman of the Board of Directors&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;29, 2009</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Roy H. Fickling
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Roy H. Fickling</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;29, 2009</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Mark Kessel
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Mark Kessel</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;29, 2009</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE></DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->5<!-- /Folio --></DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="28%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="45%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="25%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Arthur B. Laffer
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Arthur B. Laffer, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;29, 2009</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ William D. Schweiterman
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  William D. Schweiterman
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;29, 2009</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Alastair J.J. Wood
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Alastair J.J. Wood
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;29, 2009</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->6<!-- /Folio -->
  </DIV>
  
  
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>OXiGENE, Inc.</B></DIV>
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INDEX TO EXHIBITS FILED WITH<BR>
  FORM S-8 REGISTRATION STATEMENT</B></DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="7%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="88%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
  
  <TD nowrap align="left" style="border-bottom: 0px solid #000000"><U>Number</U></TD>
      <TD>&nbsp;</TD>
  
  <TD nowrap align="left" style="border-bottom: 0px solid #000000"><U>Description</U></TD>
  </TR>
  <TR valign="bottom" style="font-size:6pt"><TD>&nbsp;</TD></TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.1)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant (Filed as Exhibit to
  the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;033-64968),
  and incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.2)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificates of Amendment of Restated Certificate of Incorporation of the
  Registrant dated June&nbsp;21, 2995 and November&nbsp;15, 1996 (Filed as Exhibits to the
  Registrant&#146;s Annual Report of Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 1996
  (File No.&nbsp;000-21990), and incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.3)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Restated Certificate of Incorporation of the
  Registrant, dated July&nbsp;14, 2005 (Filed as Exhibit to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-8 (File No.&nbsp;333-126636), and incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.4)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated By-Laws of the Registrant (Filed as Exhibit to the
  Registrant&#146;s Quarterly Report on Form&nbsp;8-K, filed on December&nbsp;20, 2007 (File No.
  000-21990), and incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.5)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Certificate (Filed as Exhibit to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;033-64968), and incorporated
  herein by reference).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.6)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Stockholder Rights Agreement (Filed as Exhibit to the Registrant&#146;s
  Registration Statement on Form&nbsp;8-A, dated March&nbsp;30, 2005 (File No.&nbsp;000-21990), and
  incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(5)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the
  legality of shares being registered.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.1)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion
  of counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.2)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(24)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney to file future amendments (set forth on the signature page of
  this Registration Statement).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.1)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">OXiGENE, Inc. 2005 Stock Plan, as amended (Filed as Appendix&nbsp;B to the Registrant&#146;s
  Definitive Proxy Statement on Schedule&nbsp;14A, filed on April&nbsp;7, 2009 (File No.
  000-21990), and incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.2)</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">OXiGENE, Inc. 2009 Employee Stock Purchase Plan (Filed as Appendix&nbsp;C to the
  Registrant&#146;s Definitive Proxy Statement on Schedule&nbsp;14A, filed on April&nbsp;7, 2009 (File
  No.&nbsp;000-21990), and incorporated herein by reference).</TD>
  </TR>
  </TABLE></DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->7<!-- /Folio --></DIV>
  
  </BODY>
  </HTML>
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metadata_filer: {"company-data": {"conformed-name": "OXIGENE INC", "cik": "0000908259", "assigned-sic": "2836", "irs-number": "133679168", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-159585", "film-number": "09861393"}, "business-address": {"street1": "321 ARSENAL STREET", "city": "WATERTOWN", "state": "MA", "zip": "02472", "phone": "6176737800"}}
text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on May 29, 2009
  REGISTRATION NO. 333 -
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  under the
  SECURITIES ACT OF 1933
  OXiGENE, INC.
  (
  Exact Name of Registrant as Specified in Its Charter)
  Delaware
  (
  State or Other Jurisdiction
  of Incorporation or Organization
  )
  13-3679168
  (
  I.R.S. Employer
  Identification No.
  )
  230 Third Avenue
  Waltham, MA 02451
  (
  Address, Including Zip Code, of Principal Executive Offices
  )
  OXiGENE, INC. 2005 STOCK PLAN
  OXiGENE, INC. 2009 EMPLOYEE STOCK PURCHASE PLAN
  (Full Titles of the Plans)
  John A. Kollins
  Chief Executive Officer
  OXiGENE, Inc.
  230 Third Avenue
  Waltham, MA 02451
  781-547-5900
  (
  Name, Address and Telephone Number, Including
  Area Code, of Agent For Service
  )
  Indicate by check mark whether the registrant is a large
   accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
   of "large accelerated filer," "accelerated filer" and "smaller reporting
   company" in Rule 12b-2 of the
   Exchange Act. (Check one):
  Large accelerated filer
  o
  Accelerated filer
  o
  Non-accelerated filer
  o
  Smaller reporting company
  þ
  (Do not check if a smaller reporting company)
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  Maximum
  Maximum
  Title of
  Amount to be
  Offering Price
  Aggregate
  Amount of
  Securities to be Registered
  Registered
  (1)
  Per Share
  (2)
  Offering Price
  (2)
  Registration Fee
  Common Stock, $0.01 par value
  7,000,000
  $
  2.04
  $
  14,280,000
  $
  796.82
  Rights to purchase Common Stock
  (3
  )
  (3
  )
  (3
  )
  None
  (1)
  The number of shares of common stock, par value $0.01 per share ("Common Stock") of OXiGENE,
  Inc. (the "Registrant"), stated above consists of the aggregate number of shares which may be
  sold (i) upon the exercise of options or issuance of stock awards which may hereafter be
  granted under the OXiGENE, Inc. 2005 Stock Plan (the "Stock Plan") and (ii) under the OXiGENE,
  Inc. 2009 Employee Stock Purchase Plan (the "Purchase Plan" and together with the Stock Plan,
  the "Plans"). The maximum number of shares which may be sold upon the exercise of such
  options or issuance of stock awards granted under the Plans are subject to adjustment in
  accordance with certain anti-dilution and other provisions of the Plans. Accordingly,
  pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this
  Registration Statement covers, in addition to the number of shares stated above, an
  indeterminate number of shares which may be subject to grant or otherwise issuable after the
  operation of any such anti-dilution and other provisions.
  (2)
  This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(c) and (h) under the Securities Act on the basis of the average
  of the high and low sale prices per share of the Common Stock on the NASDAQ Global Market as
  of a date (May 26, 2009) within five business days prior to filing this Registration Statement.
  (3)
  No separate consideration will be received for the Rights.
  Table of Contents
  EXPLANATORY NOTE
  In accordance with the instructional Note to Part I of Form S-8 as promulgated by the
  Securities and Exchange Commission, the information specified by Part I of Form S-8 has been
  omitted from this Registration Statement on Form S-8 for offers of Common Stock pursuant to the
  Plans.
  Stock Plan
  .
  This Registration Statement on Form S-8 hereby registers 5,000,000 additional
  shares of Common Stock for issuance under the Stock Plan, as approved at the Annual Meeting of
  Stockholders held on May 28, 2009. On July 15, 2005, the Registrant filed a registration statement
  on Form S-8 (File No. 333-126636) to register 2,500,000 shares of Common Stock reserved for
  issuance under the Stock Plan.
  Purchase Plan.
  This Registration Statement on Form S-8 hereby registers 2,000,000 shares of
  Common Stock under the Purchase Plan, as approved at the Annual Meeting of Stockholders held on May
  28, 2009.
  TABLE OF CONTENTS
  PART II
  Item 3. Incorporation of Certain Documents by Reference
  Item 4. Description of Securities
  Item 5. Interests of Named Experts and Counsel
  Item 6. Indemnification of Directors and Officers
  Item 7. Exemption from Registration Claimed
  Item 8. Exhibits
  Item 9. Undertakings
  SIGNATURES
  Ex-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares being registered
  Ex-23.2 Consent of Ernst & Young LLP
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference
  .
  The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  (a) The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2008
  filed on March 30, 2009 (File No. 000-21990).
  (b) The Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2009 filed
  on May 15, 2009 (File No. 000-21990).
  (c) The Registrant's Current Report on Form 8-K filed on January 9, 2009 (File No. 000-21990).
  (d) The Registrant's Current Report on Form 8-K filed on March 25, 2009 (File No. 000-21990).
  (e) The Registrant's Current Report on Form 8-K filed on May 4, 2009 (File No. 000-21990).
  (f) The description of the Common Stock contained in the Registrant's Registration Statement
  on Form 8-A (File No. 000-21990) filed under the Exchange Act, with the Commission on June 25,
  1993, including any amendment or report filed for the purpose of updating such description.
  (g) The description of the Rights under the Stockholder Rights Agreement (which are currently
  transferred with the Registrant's Common Stock) contained in the Registrant's Registration
  Statement on Form 8-A12G (File No. 000-21990) filed under the Exchange Act with the Commission on
  March 30, 2005, including any amendment or report filed for the purpose of updating such
  description.
  All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective
  amendment which indicates that all securities offered hereby have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such reports and documents.
  Item 4. Description of Securities
  .
  Not applicable.
  Item 5. Interests of Named Experts and Counsel
  .
  The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C., and members of that firm, their families and trusts for their benefit own an aggregate of
  approximately 350 shares of Common Stock of the Registrant.
  Item 6. Indemnification of Directors and Officers
  .
  Incorporated by reference from the Registrant's Registration Statement on Form S-3, filed on
  November 14, 2008 (File No. 333-155372).
  1
  Table of Contents
  Item 7. Exemption from Registration Claimed
  .
  Not applicable.
  Item 8. Exhibits
  .
  (4.1)
  Restated Certificate of Incorporation of the Registrant (Filed as Exhibit to
  the Registrant's Registration Statement on Form S-1, as amended (File No. 033-64968),
  and incorporated herein by reference).
  (4.2)
  Certificates of Amendment of Restated Certificate of Incorporation of the
  Registrant dated June 21, 2995 and November 15, 1996 (Filed as Exhibits to the
  Registrant's Annual Report of Form 10-K for the fiscal year ended December 31, 1996
  (File No. 000-21990), and incorporated herein by reference).
  (4.3)
  Certificate of Amendment of Restated Certificate of Incorporation of the
  Registrant, dated July 14, 2005 (Filed as Exhibit to the Registrant's Registration
  Statement on Form S-8 (File No. 333-126636), and incorporated herein by reference).
  (4.4)
  Amended and Restated By-Laws of the Registrant (Filed as Exhibit to the
  Registrant's Quarterly Report on Form 8-K, filed on December 20, 2007 (File No.
  000-21990), and incorporated herein by reference).
  (4.5)
  Form of Common Stock Certificate (Filed as Exhibit to the Registrant's
  Registration Statement on Form S-1, as amended (File No. 033-64968), and incorporated
  herein by reference).
  (4.6)
  Stockholder Rights Agreement (Filed as Exhibit to the Registrant's
  Registration Statement on Form 8-A, dated March 30, 2005 (File No. 000-21990), and
  incorporated herein by reference).
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the
  legality of shares being registered.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion
  of counsel filed as Exhibit 5).
  (23.2)
  Consent of Ernst & Young LLP.
  (24)
  Power of Attorney to file future amendments (set forth on the signature page of
  this Registration Statement).
  (99.1)
  OXiGENE, Inc. 2005 Stock Plan, as amended (Filed as Appendix B to the Registrant's
  Definitive Proxy Statement on Schedule 14A, filed on April 7, 2009 (File No.
  000-21990), and incorporated herein by reference).
  2
  Table of Contents
  (99.2)
  OXiGENE, Inc. 2009 Employee Stock Purchase Plan (Filed as Appendix C to the
  Registrant's Definitive Proxy Statement on Schedule 14A, filed on April 7, 2009 (File
  No. 000-21990), and incorporated herein by reference).
  Item 9. Undertakings
  .
  (a)
  The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made, a post-effective
  amendment to this Registration Statement:
  (i) To include any prospectus required by Section 10(a)(3) of the Securities
  Act of 1933;
  (ii) To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental
  change in the information set forth in the Registration Statement. Notwithstanding
  the foregoing, any increase or decrease in volume of securities offered (if the
  total dollar value of securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated maximum offering range
  may be reflected in the form of prospectus filed with the Commission pursuant to
  Rule 424(b) if, in the aggregate, the changes in volume and price represent no more
  than a 20% change in the maximum aggregate offering price set forth in the
  "Calculation of Registration Fee" table in the effective Registration Statement.
  (iii) To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or any material
  change to such information in the Registration Statement;
  Provided, however
  , that Paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  registration statement is on Form S-8, Form S-3 or Form F-3, and the information required to
  be included in a post-effective amendment by those paragraphs is contained in reports filed
  with or furnished to the Commission by the Registrant pursuant to Section 13 or Section
  15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the
  Registration Statement.
  (2) That, for the purpose of determining any liability under the Securities Act of 1933,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by
  reference in this Registration Statement shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  3
  Table of Contents
  (c)
  Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed
  in the Act and is, therefore, unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense
  of any action, suit or proceeding) is asserted by such director, officer or controlling person
  in connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.
  4
  Table of Contents
  SIGNATURES
  The Registrant
  . Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
  the undersigned, thereunto duly authorized, in the City of Waltham, Massachusetts on May 29, 2009.
  OX
  i
  GENE, INC.
  By
  /s/ John A. Kollins
  John A. Kollins
  Chief Executive Officer
  Each person whose signature appears below constitutes and appoints John A. Kollins and James
  B. Murphy, and each of them singly, his true and lawful attorneys-in-fact and agents, with full
  power of substitution and resubstitution in each of them singly, for him and in his name, place and
  stead, and in any and all capacities, to sign any and all amendments (including post-effective
  amendments) to this Registration Statement on Form S-8 of OXiGENE, Inc., and to file the same, with
  all exhibits thereto and other documents in connection therewith, with the Securities and Exchange
  Commission, granting to the attorneys-in-fact and agents, and each of them, full power and
  authority to do and perform each and every act and thing requisite or necessary to be done in or
  about the premises, as full to all intents and purposes as he might or could do in person, hereby
  ratifying and confirming all that the attorneys-in-fact and agents or any of each of them or their
  substitute may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ John A. Kollins
  John A. Kollins
  Chief Executive Officer and Director
  (Principal executive officer)
  May 29, 2009
  /s/ James B. Murphy
  James B. Murphy
  Vice President and Chief Financial Officer
  (Principal financial officer and
  principal accounting officer)
  May 29, 2009
  /s/ William N. Shiebler
  William N. Shiebler
  Chairman of the Board of Directors
  May 29, 2009
  /s/ Roy H. Fickling
  Roy H. Fickling
  Director
  May 29, 2009
  /s/ Mark Kessel
  Mark Kessel
  Director
  May 29, 2009
  5
  Table of Contents
  Signature
  Title
  Date
  /s/ Arthur B. Laffer
  Arthur B. Laffer, Ph.D.
  Director
  May 29, 2009
  /s/ William D. Schweiterman
  William D. Schweiterman
  Director
  May 29, 2009
  /s/ Alastair J.J. Wood
  Alastair J.J. Wood
  Director
  May 29, 2009
  6
  Table of Contents
  OXiGENE, Inc.
  INDEX TO EXHIBITS FILED WITH
  FORM S-8 REGISTRATION STATEMENT
  Exhibit
  Number
  Description
  (4.1)
  Restated Certificate of Incorporation of the Registrant (Filed as Exhibit to
  the Registrant's Registration Statement on Form S-1, as amended (File No. 033-64968),
  and incorporated herein by reference).
  (4.2)
  Certificates of Amendment of Restated Certificate of Incorporation of the
  Registrant dated June 21, 2995 and November 15, 1996 (Filed as Exhibits to the
  Registrant's Annual Report of Form 10-K for the fiscal year ended December 31, 1996
  (File No. 000-21990), and incorporated herein by reference).
  (4.3)
  Certificate of Amendment of Restated Certificate of Incorporation of the
  Registrant, dated July 14, 2005 (Filed as Exhibit to the Registrant's Registration
  Statement on Form S-8 (File No. 333-126636), and incorporated herein by reference).
  (4.4)
  Amended and Restated By-Laws of the Registrant (Filed as Exhibit to the
  Registrant's Quarterly Report on Form 8-K, filed on December 20, 2007 (File No.
  000-21990), and incorporated herein by reference).
  (4.5)
  Form of Common Stock Certificate (Filed as Exhibit to the Registrant's
  Registration Statement on Form S-1, as amended (File No. 033-64968), and incorporated
  herein by reference).
  (4.6)
  Stockholder Rights Agreement (Filed as Exhibit to the Registrant's
  Registration Statement on Form 8-A, dated March 30, 2005 (File No. 000-21990), and
  incorporated herein by reference).
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the
  legality of shares being registered.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion
  of counsel filed as Exhibit 5).
  (23.2)
  Consent of Ernst & Young LLP.
  (24)
  Power of Attorney to file future amendments (set forth on the signature page of
  this Registration Statement).
  (99.1)
  OXiGENE, Inc. 2005 Stock Plan, as amended (Filed as Appendix B to the Registrant's
  Definitive Proxy Statement on Schedule 14A, filed on April 7, 2009 (File No.
  000-21990), and incorporated herein by reference).
  (99.2)
  OXiGENE, Inc. 2009 Employee Stock Purchase Plan (Filed as Appendix C to the
  Registrant's Definitive Proxy Statement on Schedule 14A, filed on April 7, 2009 (File
  No. 000-21990), and incorporated herein by reference).
  7