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  <TITLE>Alkermes, Inc.</TITLE>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <P align="right"><FONT size="2">Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<BR>&nbsp;</FONT>
  
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  <DIV align="center"><FONT size="4"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  </FONT></DIV>
  <DIV align="center"><FONT size="3"><B>Washington, D.C. 20549</B>
  </FONT></DIV>
  <P align="center"><HR align="center" size="1" width="23%" noshade>
  
  <DIV align="center"><FONT size="5"><B>FORM S-8</B>
  </FONT></DIV>
  <DIV align="center"><FONT size="3"><B>REGISTRATION STATEMENT<BR>
  UNDER THE SECURITIES ACT OF 1933</B>
  </FONT></DIV>
  <P align="center"><HR align="center" size="1" width="23%" noshade>
  
  <P align="center"><FONT size="6"><B>ALKERMES, INC.</B>
  </FONT>
  
  <DIV align="center"><FONT size="2">(Exact name of registrant as specified in its charter)
  </FONT></DIV>
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      <TD width="51%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="44%">&nbsp;</TD>
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      <TD align="center" valign="top"><FONT size="2">Pennsylvania</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center" valign="top"><FONT size="2">
  23-2472830</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><FONT size="2">(State or other jurisdiction of</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center" valign="top"><FONT size="2">
  (I.R.S. Employer</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><FONT size="2">incorporation or organization)</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center" valign="top"><FONT size="2">
  Identification Number)</FONT></TD>
  </TR>
  </TABLE>
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  <P align="center"><FONT size="2"><B>ALKERMES, INC.<BR>
  88 SIDNEY STREET<BR>
  CAMBRIDGE, MASSACHUSETTS 02139-4234<BR>
  TELEPHONE: (617)&nbsp;494-0171</B><BR>
  (Address, including zip code, and telephone number, including area code,<BR>
  of registrant&#146;s principal executive offices)
  </FONT>
  
  <P align="center"><FONT size="2"><B>ALKERMES, INC. 1999 STOCK OPTION PLAN<BR>
  ALKERMES, INC. STOCK OPTION PLAN<BR>
  FOR NON-EMPLOYEE DIRECTORS</B><BR>
  (Full title of the plan)
  </FONT>
  
  <P align="center"><FONT size="2">Richard F. Pops<BR>
  Chief Executive Officer<BR>
  ALKERMES, INC.<BR>
  88 Sidney Street<BR>
  Cambridge, Massachusetts 02139-4234<BR>
  Telephone: (617)&nbsp;494-0171<BR>
  (Name, address, including zip code, and telephone number, including area code,<BR>
  of agent for service)
  </FONT>
  
  <P align="center"><HR align="center" size="1" width="23%" noshade>
  
  <DIV align="center"><FONT size="2">Copies to:<BR>
  Jennifer L. Miller, Esquire<BR>
  Ballard Spahr Andrews &#038; Ingersoll, LLP<BR>
  1735 Market Street, 51<SUP>st</SUP> Floor<BR>
  Philadelphia, Pennsylvania 19103<BR>
  Telephone: (215)&nbsp;864-8619
  </FONT></DIV>
  <p align="center"><HR align="center" size="1" width="23%" noshade>
  <P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B>
  </FONT>
  
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      <TD width="34%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="11%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
  </TR>
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      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
  </TR>
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      <TD nowrap align="center"><FONT size="1"><B>Title of Securities</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount to be</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price Per</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate Offering</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>to be Registered</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered(1)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Share(2)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price(2)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration Fee</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD colspan="3"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD colspan="3"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD colspan="3"><HR size="1" noshade></TD>
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      <TD colspan="3"><HR size="1" noshade></TD>
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      <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock,
  Par value $.01 per
  share</FONT></DIV></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">3,500,000</FONT></TD>
      <TD nowrap><FONT size="2"><SUP>(3)</SUP></FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$13.08</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$45,780,000</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$3,704</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416(a) under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend and the like.</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="96%"><FONT size="2">Estimated solely for the purpose of calculating the registration fee. In
  accordance with Rule&nbsp;457(h), the price shown is based upon the average of
  the high and low price of the Company&#146;s Common Stock on
  September 29,
  2003, $13.08, as reported on the Nasdaq National Market for securities
  of the same class as those to be offered.</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="96%"><FONT size="2">This registration statement relates to 500,000 shares of Common Stock,
  $.01 par value per share, reserved for issuance under the Stock Option
  Plan for Non-Employee Directors (the &#147;Director Plan&#148;), which shares are in
  addition to 500,000 shares of Common Stock, $.01 par value per share,
  previously registered pursuant to Registration Statements on Form&nbsp;S-8 and
  filed with the Securities and Exchange Commission (Registration Nos.
  333-13283 and 333-48768) and 3,000,000 shares of Common Stock, $.01 par
  value per share, reserved for issuance under the 1999 Stock Option Plan
  (the &#147;1999 Plan&#148;), which shares are in addition to 11,400,000 shares of
  Common Stock, $.01 par value per share, previously registered pursuant to
  Registration Statements on Form&nbsp;S-8 (Registration Nos. 333-89573,
  333-48722, 333-72988 and 333-107206) and filed with the Securities and
  Exchange Commission. The current filing is being made to register the
  500,000 shares which are issuable under the Director Plan and the
  3,000,000 shares which are issuable under the 1999 Plan.</FONT></TD>
  </TR>
  </TABLE>
  <P align="center"><FONT size="2">&nbsp;</FONT>
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  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
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  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART II - INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Certain Documents by Reference</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;8. Exhibits</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#004">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#005">EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47924aiexv5.txt">Opinion of Ballard Spahr</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47924aiexv23w2.txt">Consent of Deloitte & Touche</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47924aiexv23w3.txt">Consent of Ernst & Young</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47924aiexv99w1.txt">1999 Stock Option Plan</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47924aiexv99w2.txt">Stock Option Plan</A></TD></TR>
  </TABLE>
  </CENTER>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Part I and Items 4, 6, 7 and 9 of Part II of Alkermes, Inc.&#146;s Registration
  Statements on Form&nbsp;S-8 (File Nos. 333-89573 and 333-13283) are incorporated by
  reference herein pursuant to Instruction E of Form&nbsp;S-8.
  </FONT>
  
  <!-- link1 "PART II - INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  <P align="center"><FONT size="2">PART II - INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  </FONT>
  
  <!-- link2 "Item&nbsp;3. Incorporation of Certain Documents by Reference" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;3. Incorporation of Certain Documents by Reference.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed with the Securities and Exchange Commission
  (the &#147;Commission&#148;) pursuant to the Securities Exchange Act of 1934 (the
  &#147;Exchange Act&#148;) by Alkermes, Inc. (the &#147;Company&#148;) (File No.&nbsp;1-14131) or
  pursuant to the Securities Act of 1933, as amended (the &#147;Securities Act&#148;) are
  incorporated herein by reference:
  </FONT>
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR valign="top">
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(a)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%"><FONT size="2">Annual Report on Form&nbsp;10-K for the fiscal year
  ended March&nbsp;31, 2003;</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(b)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%"><FONT size="2">Quarterly Report on Form&nbsp;10-Q for the period
  ended June&nbsp;30, 2003;</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(c)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%"><FONT size="2">Item&nbsp;1 of Registration Statement of the Company
  on Form&nbsp;8-A dated June&nbsp;28, 1991, as amended by a Registration
  Statement of the Company on Form&nbsp;8-A/A dated January&nbsp;17, 1997;
  and</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(d)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%"><FONT size="2">Item&nbsp;1 of Registration Statement of the Company
  on Form&nbsp;8-A dated May&nbsp;2, 2003.</FONT></TD>
  </TR>
  </TABLE>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14
  or 15(d) of the Exchange Act, after the date of this Registration Statement and
  prior to the termination of the offering, shall be deemed to be incorporated by
  reference herein and to be part hereof from the date of filing such documents.
  Any statement contained herein or in a document incorporated by reference or
  deemed to be incorporated by reference herein shall be deemed to be modified or
  superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document
  which is incorporated or is deemed to be incorporated by reference herein. Any
  such statement so modified or superseded shall not be deemed, except as so
  modified or superseded, to constitute a part of this Registration Statement.
  </FONT>
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Morris Cheston, Jr., Esquire, Secretary of the Company and Jennifer L.
  Miller, Esquire, Secretary of Alkermes Investments, Inc., a wholly-owned
  subsidiary of Alkermes, Inc., are both partners in the law firm of Ballard
  Spahr Andrews &#038; Ingersoll, LLP which has given an opinion passing upon the
  validity of the securities being registered hereby.
  </FONT>
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits.</B>
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1 as amended (File No.&nbsp;33-40250)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Non-Voting Common Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit&nbsp;4.4 to the Registrant&#146;s
  Report on Form&nbsp;10-K for the fiscal year ended March&nbsp;31, 1999).</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">&nbsp;</FONT>
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  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of 2002 Preferred Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s
  Current Report on Form&nbsp;8-K filed on December&nbsp;13, 2002).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.4</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Indenture, dated as of February&nbsp;18, 2000, between Alkermes,
  Inc. and State Street Bank and Trust Company, as Trustee (3.75%
  Subordinated Notes). (Incorporated by reference to Exhibit&nbsp;4.6 to
  the Registrant&#146;s Registration Statement on Form&nbsp;S-3, as amended
  (File No.&nbsp;333-31354)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Indenture, dated August&nbsp;22, 2003, between Alkermes, Inc. and
  U.S. Bank National Association as Trustee (2&#189;% Subordinated
  Notes) (Incorporated by reference to Exhibit&nbsp;4.7 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1 (File No.&nbsp;333-108483)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.6</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Rights Agreement, dated February&nbsp;7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s
  Registration Statement on Form&nbsp;8-A filed on May&nbsp;2, 2003).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Opinion of Ballard Spahr Andrews &#038; Ingersoll, LLP as to the
  legality of the securities to be offered.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Ballard Spahr Andrews &#038; Ingersoll, LLP (included as part of Exhibit&nbsp;5).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Independent Auditors&#146; Consent of Deloitte &#038; Touche LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Independent Auditors of Ernst &#038; Young LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">24</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Power of Attorney (included in signature page).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">99.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Alkermes, Inc. 1999 Stock Option Plan, as amended.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">99.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Alkermes, Inc. Stock Option Plan for Non-Employee Directors, as amended.</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">&nbsp;</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  <P align="center"><FONT size="2">SIGNATURES
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form&nbsp;S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of Cambridge, Commonwealth of Massachusetts, on October&nbsp;1, 2003.
  </FONT>
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="55%">
  <TR valign="bottom">
      <TD width="40%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="60%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD colspan="3" valign="top" align="left"><FONT size="2">ALKERMES, INC.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  By
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">/s/ Richard F. Pops</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Richard F. Pops</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Chief Executive Officer</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed below by the following persons in the
  capacities and on the dates indicated.
  </FONT>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below in so signing also makes,
  constitutes and appoints Richard F. Pops and James M. Frates, and each of them,
  his true and lawful attorney-in-fact, with full power of substitution, for him
  in any and all capacities, to execute and cause to be filed with the Securities
  and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in
  connection therewith, and hereby ratifies and confirms all that said
  attorney-in-fact or his substitute or substitutes may do or cause to be done by
  virtue hereof.
  </FONT>
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="24%">&nbsp;</TD>
      <TD width="8%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="8%">&nbsp;</TD>
      <TD width="25%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Michael A. Wall
  <HR size="1" noshade>
  Michael A. Wall</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director and
  Chairman of the
  Board
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">October&nbsp;1, 2003</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Richard F. Pops
  <HR size="1" noshade>
  Richard F. Pops</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director and Chief
  Executive Officer<BR>
  (Principal
  Executive Officer)
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">October&nbsp;1, 2003</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ James M. Frates
  <HR size="1" noshade>
  James M. Frates</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Vice President, Chief
  Financial Officer and
  Treasurer<BR>
  (Principal Financial Officer
  and Principal Accounting
  Officer)
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">October&nbsp;1, 2003</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Floyd E. Bloom
  <HR size="1" noshade>
  Floyd E. Bloom</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">October&nbsp;1, 2003</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">&nbsp;</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="24%">&nbsp;</TD>
      <TD width="8%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="8%">&nbsp;</TD>
      <TD width="25%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Robert A. Breyer
  <HR size="1" noshade>
  Robert A. Breyer</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">October&nbsp;1, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Gerri Henwood
  <HR size="1" noshade>
  Gerri Henwood</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">October&nbsp;1, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Paul J. Mitchell
  <HR size="1" noshade>
  Paul J. Mitchell</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">October&nbsp;1, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Alexander Rich
  <HR size="1" noshade>
  Alexander Rich</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">October&nbsp;1, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Paul Schimmel
  <HR size="1" noshade></FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">October&nbsp;1, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">Paul Schimmel</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">&nbsp;</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <!-- link1 "EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  <P align="center"><FONT size="2"><B>EXHIBIT INDEX</B>
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Number</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Exhibit</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by
  reference to Exhibit&nbsp;4 to the Registrant&#146;s Registration Statement on Form
  S-1 as amended (File No.&nbsp;33-40250)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Non-Voting Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4.4 to the Registrant&#146;s Report on
  Form&nbsp;10-K for the fiscal year ended March&nbsp;31, 1999).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Current
  Report on Form&nbsp;8-K filed on December&nbsp;13, 2002).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.4</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Indenture, dated as of February&nbsp;18, 2000, between Alkermes, Inc. and
  State Street Bank and Trust Company, as Trustee (3.75% Subordinated
  Notes). (Incorporated by reference to Exhibit&nbsp;4.6 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-3, as amended (File No.&nbsp;333-31354)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Indenture, dated August&nbsp;22, 2003, between Alkermes, Inc. and U.S. Bank
  National Association as Trustee (2&#189;% Subordinated Notes) (Incorporated
  by reference to Exhibit&nbsp;4.7 to the Registrant&#146;s Registration Statement on
  Form&nbsp;S-1 (File No.&nbsp;333-108483)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.6</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Rights Agreement, dated February&nbsp;7, 2003, as amended, between Alkermes,
  Inc. and EquiServe Trust Co., N.A., as Rights Agent. (Incorporated by
  reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Registration Statement on
  Form&nbsp;8-A filed on May&nbsp;2, 2003).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Opinion of Ballard Spahr Andrews &#038; Ingersoll, LLP as to the legality of
  the securities to be offered.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Ballard Spahr Andrews &#038; Ingersoll, LLP (included as part of Exhibit&nbsp;5).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Independent Auditors&#146; Consent of Deloitte &#038; Touche LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Independent Auditors of Ernst &#038; Young LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">24</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Power of Attorney (included in signature page).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">99.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Alkermes, Inc. 1999 Stock Option Plan, as amended.</FONT></TD>
  </TR>
  
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      <TD valign="top"><FONT size="2">99.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Alkermes, Inc. Stock Option Plan for Non-Employee Directors, as amended.</FONT></TD>
  </TR>
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metadata_filer: {"company-data": {"conformed-name": "ALKERMES INC", "cik": "0000874663", "assigned-sic": "2834", "irs-number": "232472830", "state-of-incorporation": "PA", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-109376", "film-number": "03921619"}, "business-address": {"street1": "88 SIDNEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02139-4136", "phone": "617-494-0171"}}
text: Alkermes, Inc.
  Table of Contents
  Registration No. 333-
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER THE SECURITIES ACT OF 1933
  ALKERMES, INC.
  (Exact name of registrant as specified in its charter)
  Pennsylvania
  23-2472830
  (State or other jurisdiction of
  (I.R.S. Employer
  incorporation or organization)
  Identification Number)
  ALKERMES, INC.
  88 SIDNEY STREET
  CAMBRIDGE, MASSACHUSETTS 02139-4234
  TELEPHONE: (617) 494-0171
  (Address, including zip code, and telephone number, including area code,
  of registrant's principal executive offices)
  ALKERMES, INC. 1999 STOCK OPTION PLAN
  ALKERMES, INC. STOCK OPTION PLAN
  FOR NON-EMPLOYEE DIRECTORS
  (Full title of the plan)
  Richard F. Pops
  Chief Executive Officer
  ALKERMES, INC.
  88 Sidney Street
  Cambridge, Massachusetts 02139-4234
  Telephone: (617) 494-0171
  (Name, address, including zip code, and telephone number, including area code,
  of agent for service)
  Copies to:
  Jennifer L. Miller, Esquire
  Ballard Spahr Andrews & Ingersoll, LLP
  1735 Market Street, 51
  st
  Floor
  Philadelphia, Pennsylvania 19103
  Telephone: (215) 864-8619
  CALCULATION OF REGISTRATION FEE
  Proposed Maximum
  Proposed Maximum
  Title of Securities
  Amount to be
  Offering Price Per
  Aggregate Offering
  Amount of
  to be Registered
  Registered(1)
  Share(2)
  Price(2)
  Registration Fee
  Common Stock,
  Par value $.01 per
  share
  3,500,000
  (3)
  $13.08
  $45,780,000
  $3,704
  Table of Contents
  (1)
  Pursuant to Rule 416(a) under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend and the like.
  (2)
  Estimated solely for the purpose of calculating the registration fee. In
  accordance with Rule 457(h), the price shown is based upon the average of
  the high and low price of the Company's Common Stock on
  September 29,
  2003, $13.08, as reported on the Nasdaq National Market for securities
  of the same class as those to be offered.
  (3)
  This registration statement relates to 500,000 shares of Common Stock,
  $.01 par value per share, reserved for issuance under the Stock Option
  Plan for Non-Employee Directors (the "Director Plan"), which shares are in
  addition to 500,000 shares of Common Stock, $.01 par value per share,
  previously registered pursuant to Registration Statements on Form S-8 and
  filed with the Securities and Exchange Commission (Registration Nos.
  333-13283 and 333-48768) and 3,000,000 shares of Common Stock, $.01 par
  value per share, reserved for issuance under the 1999 Stock Option Plan
  (the "1999 Plan"), which shares are in addition to 11,400,000 shares of
  Common Stock, $.01 par value per share, previously registered pursuant to
  Registration Statements on Form S-8 (Registration Nos. 333-89573,
  333-48722, 333-72988 and 333-107206) and filed with the Securities and
  Exchange Commission. The current filing is being made to register the
  500,000 shares which are issuable under the Director Plan and the
  3,000,000 shares which are issuable under the 1999 Plan.
  TABLE OF CONTENTS
  PART II - INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference
  Item 5. Interests of Named Experts and Counsel
  Item 8. Exhibits
  SIGNATURES
  EXHIBIT INDEX
  Opinion of Ballard Spahr
  Consent of Deloitte & Touche
  Consent of Ernst & Young
  1999 Stock Option Plan
  Stock Option Plan
  Table of Contents
  Part I and Items 4, 6, 7 and 9 of Part II of Alkermes, Inc.'s Registration
  Statements on Form S-8 (File Nos. 333-89573 and 333-13283) are incorporated by
  reference herein pursuant to Instruction E of Form S-8.
  PART II - INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference.
  The following documents filed with the Securities and Exchange Commission
  (the "Commission") pursuant to the Securities Exchange Act of 1934 (the
  "Exchange Act") by Alkermes, Inc. (the "Company") (File No. 1-14131) or
  pursuant to the Securities Act of 1933, as amended (the "Securities Act") are
  incorporated herein by reference:
  (a)
  Annual Report on Form 10-K for the fiscal year
  ended March 31, 2003;
  (b)
  Quarterly Report on Form 10-Q for the period
  ended June 30, 2003;
  (c)
  Item 1 of Registration Statement of the Company
  on Form 8-A dated June 28, 1991, as amended by a Registration
  Statement of the Company on Form 8-A/A dated January 17, 1997;
  and
  (d)
  Item 1 of Registration Statement of the Company
  on Form 8-A dated May 2, 2003.
  All documents filed by the Company pursuant to Sections 13(a), 13(c), 14
  or 15(d) of the Exchange Act, after the date of this Registration Statement and
  prior to the termination of the offering, shall be deemed to be incorporated by
  reference herein and to be part hereof from the date of filing such documents.
  Any statement contained herein or in a document incorporated by reference or
  deemed to be incorporated by reference herein shall be deemed to be modified or
  superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document
  which is incorporated or is deemed to be incorporated by reference herein. Any
  such statement so modified or superseded shall not be deemed, except as so
  modified or superseded, to constitute a part of this Registration Statement.
  Item 5. Interests of Named Experts and Counsel.
  Morris Cheston, Jr., Esquire, Secretary of the Company and Jennifer L.
  Miller, Esquire, Secretary of Alkermes Investments, Inc., a wholly-owned
  subsidiary of Alkermes, Inc., are both partners in the law firm of Ballard
  Spahr Andrews & Ingersoll, LLP which has given an opinion passing upon the
  validity of the securities being registered hereby.
  Item 8. Exhibits.
  4.1
  Specimen of Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4 to the Registrant's
  Registration Statement on Form S-1 as amended (File No. 33-40250)).
  4.2
  Specimen of Non-Voting Common Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit 4.4 to the Registrant's
  Report on Form 10-K for the fiscal year ended March 31, 1999).
  Table of Contents
  4.3
  Specimen of 2002 Preferred Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit 4.1 to the Registrant's
  Current Report on Form 8-K filed on December 13, 2002).
  4.4
  Indenture, dated as of February 18, 2000, between Alkermes,
  Inc. and State Street Bank and Trust Company, as Trustee (3.75%
  Subordinated Notes). (Incorporated by reference to Exhibit 4.6 to
  the Registrant's Registration Statement on Form S-3, as amended
  (File No. 333-31354)).
  4.5
  Indenture, dated August 22, 2003, between Alkermes, Inc. and
  U.S. Bank National Association as Trustee (2½% Subordinated
  Notes) (Incorporated by reference to Exhibit 4.7 to the Registrant's
  Registration Statement on Form S-1 (File No. 333-108483)).
  4.6
  Rights Agreement, dated February 7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's
  Registration Statement on Form 8-A filed on May 2, 2003).
  5
  Opinion of Ballard Spahr Andrews & Ingersoll, LLP as to the
  legality of the securities to be offered.
  23.1
  Consent of Ballard Spahr Andrews & Ingersoll, LLP (included as part of Exhibit 5).
  23.2
  Independent Auditors' Consent of Deloitte & Touche LLP.
  23.3
  Consent of Independent Auditors of Ernst & Young LLP.
  24
  Power of Attorney (included in signature page).
  99.1
  Alkermes, Inc. 1999 Stock Option Plan, as amended.
  99.2
  Alkermes, Inc. Stock Option Plan for Non-Employee Directors, as amended.
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of Cambridge, Commonwealth of Massachusetts, on October 1, 2003.
  ALKERMES, INC.
  By
  /s/ Richard F. Pops
  Richard F. Pops
  Chief Executive Officer
  Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed below by the following persons in the
  capacities and on the dates indicated.
  Each person whose signature appears below in so signing also makes,
  constitutes and appoints Richard F. Pops and James M. Frates, and each of them,
  his true and lawful attorney-in-fact, with full power of substitution, for him
  in any and all capacities, to execute and cause to be filed with the Securities
  and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in
  connection therewith, and hereby ratifies and confirms all that said
  attorney-in-fact or his substitute or substitutes may do or cause to be done by
  virtue hereof.
  Signature
  Title
  Date
  /s/ Michael A. Wall
  Michael A. Wall
  Director and
  Chairman of the
  Board
  October 1, 2003
  /s/ Richard F. Pops
  Richard F. Pops
  Director and Chief
  Executive Officer
  (Principal
  Executive Officer)
  October 1, 2003
  /s/ James M. Frates
  James M. Frates
  Vice President, Chief
  Financial Officer and
  Treasurer
  (Principal Financial Officer
  and Principal Accounting
  Officer)
  October 1, 2003
  /s/ Floyd E. Bloom
  Floyd E. Bloom
  Director
  October 1, 2003
  Table of Contents
  Signature
  Title
  Date
  /s/ Robert A. Breyer
  Robert A. Breyer
  Director
  October 1, 2003
  /s/ Gerri Henwood
  Gerri Henwood
  Director
  October 1, 2003
  /s/ Paul J. Mitchell
  Paul J. Mitchell
  Director
  October 1, 2003
  /s/ Alexander Rich
  Alexander Rich
  Director
  October 1, 2003
  /s/ Paul Schimmel
  Director
  October 1, 2003
  Paul Schimmel
  Table of Contents
  EXHIBIT INDEX
  Number
  Exhibit
  4.1
  Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by
  reference to Exhibit 4 to the Registrant's Registration Statement on Form
  S-1 as amended (File No. 33-40250)).
  4.2
  Specimen of Non-Voting Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4.4 to the Registrant's Report on
  Form 10-K for the fiscal year ended March 31, 1999).
  4.3
  Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's Current
  Report on Form 8-K filed on December 13, 2002).
  4.4
  Indenture, dated as of February 18, 2000, between Alkermes, Inc. and
  State Street Bank and Trust Company, as Trustee (3.75% Subordinated
  Notes). (Incorporated by reference to Exhibit 4.6 to the Registrant's
  Registration Statement on Form S-3, as amended (File No. 333-31354)).
  4.5
  Indenture, dated August 22, 2003, between Alkermes, Inc. and U.S. Bank
  National Association as Trustee (2½% Subordinated Notes) (Incorporated
  by reference to Exhibit 4.7 to the Registrant's Registration Statement on
  Form S-1 (File No. 333-108483)).
  4.6
  Rights Agreement, dated February 7, 2003, as amended, between Alkermes,
  Inc. and EquiServe Trust Co., N.A., as Rights Agent. (Incorporated by
  reference to Exhibit 4.1 to the Registrant's Registration Statement on
  Form 8-A filed on May 2, 2003).
  5
  Opinion of Ballard Spahr Andrews & Ingersoll, LLP as to the legality of
  the securities to be offered.
  23.1
  Consent of Ballard Spahr Andrews & Ingersoll, LLP (included as part of Exhibit 5).
  23.2
  Independent Auditors' Consent of Deloitte & Touche LLP.
  23.3
  Consent of Independent Auditors of Ernst & Young LLP.
  24
  Power of Attorney (included in signature page).
  99.1
  Alkermes, Inc. 1999 Stock Option Plan, as amended.
  99.2
  Alkermes, Inc. Stock Option Plan for Non-Employee Directors, as amended.