content: <HTML>
  <HEAD>
  <TITLE>CALIPER LIFE SCIENCES, INC.</TITLE>
  </HEAD>
  <BODY bgcolor="#FFFFFF">
  <!-- PAGEBREAK -->
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <P align="center" style="font-size: 10pt">As filed with the
  Securities and Exchange Commission on July&nbsp;9, 2004<BR>
  Registration No.&nbsp;333-
  
  
  
  <HR size="4" noshade color="#000000" style="margin-top: -5px">
  <HR size="1" noshade color="#000000" style="margin-top: -10px">
  
  
  
  
  
  <P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
  </DIV>
  
  <P align="center" style="font-size: 18pt"><B>FORM S-8</B>
  
  
  <P align="center" style="font-size: 10pt">REGISTRATION STATEMENT<BR>
  UNDER<BR>
  THE SECURITIES ACT OF 1933
  
  
  <P align="center" style="font-size: 24pt"><B>CALIPER LIFE SCIENCES, INC.</B>
  
  <DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="65%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B><BR>
  (State or other Jurisdiction of<BR>
  Incorporation or Organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>33-0675808</B><BR>
  (I.R.S. Employer Identification No.)</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt"><B>68 ELM STREET<BR>
  HOPKINTON, MA 01748</B><BR>
  (Address of principal executive offices, including zip code)
  
  
  
  <P align="center" style="font-size: 10pt"><B>1999 EQUITY INCENTIVE PLAN<BR>
  1999 EMPLOYEE STOCK PURCHASE PLAN<BR>
  1999 NON-EMPLOYEE DIRECTORS&#146; STOCK OPTION PLAN</B><BR>
  (Full title of the plans)
  
  
  
  <P align="center" style="font-size: 10pt"><B>E. Kevin Hrusovsky<BR>
  President and Chief Executive Officer<BR>
  Caliper Life Sciences, Inc.<BR>
  68 Elm Street<BR>
  Hopkinton, MA 01748<BR>
  (508)&nbsp;435-9500</B><BR>
  (Name, address, including zip code, and telephone number, including area code,<BR>
  of agent for service)
  
  
  
  <P align="center" style="font-size: 10pt"><B>Copies to:<BR>
  Brett D. White, Esq.<BR>
  COOLEY GODWARD LLP<BR>
  Five Palo Alto Square<BR>
  3000 El Camino Real<BR>
  Palo Alto, California 94306<BR>
  (650)&nbsp;843-5000</B>
  
  
  
  <P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="27%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="6%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="11%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="11%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="6%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="left"><B>Title of Each Class</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed Maximum</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed Maximum</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="left"><B>of Securities</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Offering</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Aggregate</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="left"><B>to be Registered</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount to be Registered</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Price per Share</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Offering Price</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Registration Fee</B></TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
                      <TD valign="top" style="border-top: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Common Stock (par
  value $0.001)
  </DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">458,061</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">(1)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">4.82</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">(2)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">2,205,563.70</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">(2)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">279.44</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">(2)</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD valign="top" style="border-top: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Preferred Share<BR>
  Purchase Rights
  </DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">458,061</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">(3</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">(3</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">(3</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">)</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px solid #000000">&nbsp;</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  <P>
  
  <HR size="1" width="18%" align="left" noshade>
  
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(1)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">8,845 shares to be registered pursuant to the 1999 Equity Incentive Plan,
  354,079 shares to be registered pursuant to the 1999 Employee Stock
  Purchase Plan and 95,137 shares to be registered pursuant to the 1999
  Non-Employee Directors&#146; Stock Option Plan. This Registration Statement
  shall cover any additional shares of Common Stock which become issuable
  under the plans set forth herein by reason of any stock dividend, stock
  split, recapitalization or any other similar transaction without receipt
  of consideration which results in an increase in the number of shares of
  the Registrant&#146;s outstanding Common Stock.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(2)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Estimated solely for the purpose of calculating the amount of the
  registration fee pursuant to Rule&nbsp;457(h). The price per share and
  aggregate offering price of the shares to be offered under these plans
  are based upon the average of the high and low prices of the Registrant&#146;s
  Common Stock on July&nbsp;6, 2004 as reported on the Nasdaq National Market
  (pursuant to Rule 457(c) under the Act) for shares reserved for future
  issuance under the plans.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(3)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Preferred Share Purchase Rights, which are attached to the shares of
  Common Stock to be issued but do not trade separately from the shares of
  Common Stock until a triggering event. No additional offering price
  attaches to these rights.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#000">ITEM 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">ITEM 4. DESCRIPTION OF SECURITIES</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">ITEM 8. EXHIBITS</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">ITEM 9. UNDERTAKINGS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#007">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#008">POWER OF ATTORNEY</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b51095s8exv5w1.htm">EX-5.1 OPINION OF COOLEY GODWARD LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b51095s8exv23w1.htm">EX-23.1 CONSENT OF ERNST & YOUNG LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link2 "ITEM 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>ITEM 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</B>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by Caliper Life Sciences, Inc. (the
  &#147;Company&#148;) with the Securities and Exchange Commission are incorporated by
  reference into this Registration Statement:
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(a)&nbsp;</B>The Company&#146;s Annual Report on Form 10-K for the fiscal year
  ended December&nbsp;31, 2003 filed on March&nbsp;15, 2004.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(b)&nbsp;</B>The Company&#146;s Quarterly Report on Form 10-Q for the quarter
  ended March&nbsp;31, 2004 filed on May&nbsp;10, 2004.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(c)&nbsp;</B>The description of the Company&#146;s common stock which is
  contained in the Registration Statement on Form 8-A filed November
  22, 1999, under the Exchange Act, including any amendment or report
  filed for the purpose of updating such description.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents subsequently filed by the Company pursuant
  to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing
  of a post-effective amendment which indicates that all securities offered have
  been sold or which deregisters all securities then remaining unsold, shall be
  deemed to be incorporated by reference herein and to be a part of this
  registration statement from the date of the filing of such reports and
  documents.
  
  <!-- link2 "ITEM 4. DESCRIPTION OF SECURITIES" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>ITEM 4. DESCRIPTION OF SECURITIES</B>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Preferred Share Purchase Rights (the &#147;Rights&#148;) are not currently
  registered under the Exchange Act. Each share of Common Stock issued or
  outstanding has attached to it a Right. Each Right entitles the registered
  holder to purchase from Caliper one one-hundredth of a share of Series&nbsp;A Junior
  Participating Preferred Stock, par value $0.001 per share (the &#147;Preferred
  Shares&#148;), at a price of $100.00 per one one-hundredth of a Preferred Share (the
  &#147;Purchase Price&#148;), subject to adjustment. Each one one-hundredth of a share of
  Preferred Shares has designations and powers, preferences and rights, and the
  qualifications, limitations and restrictions which make its value approximately
  equal to the value of a Common Share.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Rights are currently evidenced by the stock certificates representing
  the Common Shares outstanding, and no separate Right Certificates, as defined,
  have been distributed. Until the earlier to occur of (i)&nbsp;subject to limited
  exceptions, the date of a public announcement that a person, entity or group of
  affiliated or associated persons have acquired beneficial ownership of 15% or
  more of the outstanding Common Shares (an &#147;Acquiring Person&#148;) or (ii)&nbsp;10
  business days (or such later date as may be determined by action of the Board
  of Directors prior to such time as any person or entity becomes an Acquiring
  Person) following the commencement of, or announcement of an intention to
  commence, a tender offer or exchange offer the consummation of which would
  result in any person or entity becoming an Acquiring Person (the earlier of
  such dates being called the &#147;Distribution Date&#148;), the Rights will be evidenced,
  with respect to any of the Common Share certificates, by such Common Share
  certificate.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Until the Distribution Date, the Rights will be transferable with and only
  with the Common Shares. As soon as practicable following the Distribution Date,
  separate certificates evidencing the Rights (&#147;Right Certificates&#148;) will be
  mailed to holders of record of the Common Shares as of the close of business on
  the Distribution Date and such separate Right Certificates alone will evidence
  the Rights.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Rights are not exercisable until the Distribution Date. The Rights
  will expire on December&nbsp;17, 2011 (the &#147;Final Expiration Date&#148;), unless the
  Rights are earlier redeemed or exchanged by Caliper, in each case, as described
  below. The Rights are protected by customary anti-dilution provisions to
  protect the value of the Rights in the event of a stock dividend on, or a
  subdivision, combination or reclassification of, the Preferred Shares or the
  Common Stock, and in certain other events.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Preferred Shares purchasable upon exercise of the Rights will not be
  redeemable. Each Preferred Share will be entitled to a minimum preferential
  quarterly dividend payment of $1.00 but will be entitled to an aggregate
  dividend of 100 times the dividend declared per Common Share. In the event of
  liquidation, the holders of the Preferred Shares would be entitled to a minimum
  preferential liquidation payment of $100 per share, but would be
  entitled to receive an aggregate payment equal to 100 times the payment
  made per Common Share. Each Preferred
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <P align="left" style="font-size: 10pt">Share will have 100 votes, voting
  together with the Common Shares. Finally, in the event of any merger,
  consolidation or other transaction in which Common Shares are exchanged, each
  Preferred Share will be entitled to receive 100 times the amount of
  consideration received per Common Share. These rights are protected by
  customary anti-dilution provisions. Because of the nature of the Preferred
  Shares&#146; dividend and liquidation rights, the value of one one-hundredth of a
  Preferred Share should approximate the value of one Common Share. The Preferred
  Shares would rank junior to any other series of Caliper&#146;s preferred stock.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In the event that any person or group of affiliated or associated persons
  becomes an Acquiring Person, proper provision shall be made so that each holder
  of a Right, other than Rights beneficially owned by the Acquiring Person and
  its associates and affiliates (which will thereafter be void), will for a
  60-day period have the right to receive upon exercise that number of Common
  Shares having a market value of two times the exercise price of the Right (or,
  if such number of shares is not and cannot be authorized, Caliper may issue
  Preferred Shares, cash, debt, stock or a combination thereof in exchange for
  the Rights). This right will terminate 60&nbsp;days after the date on which the
  Rights become nonredeemable (as described below), unless there is an injunction
  or similar obstacle to exercise of the Rights, in which event this right will
  terminate 60&nbsp;days after the date on which the Rights again become exercisable.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In the event that Caliper is acquired in a merger or other business
  combination transaction or 50% or more of its consolidated assets or earning
  power are sold to an Acquiring Person, its associates or affiliates or certain
  other persons in which such persons have an interest, proper provision will be
  made so that each holder of a Right will thereafter have the right to receive,
  upon the exercise thereof at the then current exercise price of the Right, that
  number of shares of common stock of the acquiring company which at the time of
  such transaction will have a market value of two times the exercise price of
  the Right.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;At any time after an Acquiring Person becomes an Acquiring Person and
  prior to the acquisition by such Acquiring Person of 50% or more of the
  outstanding Common Shares, the Board of Directors of Caliper may exchange the
  Rights (other than Rights owned by such person or group which have become
  void), in whole or in part, at an exchange ratio of one Common Share, or one
  one-hundredth of a Preferred Share, per Right (or, at the election of Caliper,
  Caliper may issue cash, debt, stock or a combination thereof in exchange for
  the Rights), subject to adjustment.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;At any time prior to the earliest of (i)&nbsp;the day of the first public
  announcement that a person has become an Acquiring Person or (ii)&nbsp;the Final
  Expiration Date, the Board of Directors of Caliper may redeem the Rights in
  whole, but not in part, at a price of $0.01 per Right (the &#147;Redemption Price&#148;).
  Following the expiration of the above periods, the Rights become nonredeemable.
  Immediately upon any redemption of the Rights, the right to exercise the Rights
  will terminate and the only right of the holders of Rights will be to receive
  the Redemption Price.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The terms of the Rights may be amended by the Board of Directors of
  Caliper without the consent of the holders of the Rights, except that from and
  after such time as the rights are distributed no such amendment may adversely
  affect the interest of the holders of the Rights excluding the interests of an
  Acquiring Person.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Until a Right is exercised, the holder thereof, as such, will have no
  rights as a stockholder of Caliper, including, without limitation, the right to
  vote or to receive dividends.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Rights have certain anti-takeover effects. The Rights will cause
  substantial dilution to a person or group that attempts to acquire Caliper on
  terms not approved by Caliper&#146;s Board of Directors. The Rights should not
  interfere with any merger or other business combination approved by the Board
  of Directors since the Rights may be amended to permit such acquisition or
  redeemed by Caliper at $0.01 per Right prior to the earliest of (i)&nbsp;the time
  that a person or group has acquired beneficial ownership of 15% or more of the
  Common Shares or (ii)&nbsp;the final expiration date of the rights.
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link2 "ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL</B>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  
  <!-- link2 "ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS</B>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Under Section&nbsp;145 of the Delaware General Corporation Law the Company has
  broad powers to indemnify its directors and officers against liabilities they
  may incur in such capacities, including liabilities under the Securities Act.
  The Company&#146;s bylaws require the Company to indemnify its directors and
  executive officers, and permit the Company to indemnify its other officers,
  employees and other agents, to the fullest extent permitted by Delaware law.
  The bylaws also require the Company to advance litigation expenses in the case
  of stockholder derivative actions or other actions, against an undertaking by
  the indemnified party to repay such advances if it is ultimately determined
  that the indemnified party is not entitled to indemnification.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Company has entered into indemnity agreements with each of its
  directors and executive officers. Such indemnity agreements contain provisions
  which are in some respects broader than the specific indemnification provisions
  contained in Delaware law. The Company also maintains an insurance policy for
  its directors and executive officers insuring against certain liabilities
  arising in their capacities as such.
  
  <!-- link2 "ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED</B>
  
  
  <P align="left" style="font-size: 10pt">Not applicable.
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link2 "ITEM 8. EXHIBITS" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>ITEM 8. EXHIBITS</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="75%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="11%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="84%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Exhibit</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>&nbsp;</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Number</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Description</B></TD>
  </TR>
  
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1(1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3(2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated Bylaws of Caliper.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4(3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen Stock Certificate.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5(4)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, dated as of December&nbsp;18, 2001, between Registrant
  and Wells Fargo Bank Minnesota, N.A., as Rights Agent.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Cooley Godward LLP.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, registered public accounting firm.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Cooley Godward LLP. Reference is made to Exhibit&nbsp;5.1.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney. Reference is made to Signature Page.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">1999 Equity Incentive Plan.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.3(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">1999 Employee Stock Purchase Plan.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.4(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">1999 Non-Employee Directors&#146; Stock Option Plan.</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  <P>
  
  <HR size="1" width="18%" align="left" noshade>
  
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(1)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as Exhibit&nbsp;3.1 to the quarterly report on Form 10-Q for
  the quarter ended March&nbsp;31, 2004, filed May&nbsp;10, 2004, and incorporated
  herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(2)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as Exhibit&nbsp;3.3 to the quarterly report on Form 10-Q for
  the quarter ended June&nbsp;30, 2003, filed August&nbsp;14, 2003, and incorporated
  herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(3)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as Exhibit&nbsp;4.2 to the Registration Statement on Form S-1
  (No.&nbsp;333-88827), as amended, and incorporated herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(4)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as Exhibit&nbsp;99.1 to Current Report on Form 8-K filed
  December&nbsp;19, 2001, and incorporated herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(5)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as the like-numbered Exhibit to the Registration
  Statement on Form&nbsp;S-8 (No.&nbsp;333-95007), and incorporated herein by
  reference.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  <!-- link2 "ITEM 9. UNDERTAKINGS" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>ITEM 9. UNDERTAKINGS</B>
  
  <P align="left" style="font-size: 10pt"><B>A. </B>The undersigned registrant hereby undertakes:
  
  
  
  <P>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To file, during any period in which offers or sales are being
  made, a post-effective amendment to this registration statement:</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="6%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right"><B>(i)</B></TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To include any prospectus required by section
  10(a)(3) of the Securities Act;</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="6%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right"><B>(ii)</B></TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To reflect in the prospectus any facts or events
  arising after the effective date of the registration statement
  (or the most recent post-effective amendment thereof) which,
  individually or in the aggregate, represent a fundamental
  change in the information set forth in the registration
  statement. Notwithstanding the foregoing, any increase or
  decrease in volume of securities offered (if the total dollar
  value of securities offered would not exceed that which was
  registered) and any deviation from the low or high end of the
  estimated maximum offering range may be reflected in the form
  of prospectus filed with the Commission pursuant to Rule
  424(b) (&#167; 230.424(b) of this chapter) if, in the aggregate,
  the changes in volume and price represent no more than a 20%
  change in the maximum aggregate offering price set forth in
  the &#147;Calculation of Registration Fee&#148; table in the effective
  registration statement.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="6%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right"><B>(iii)</B></TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To include any material information with respect
  to the plan of distribution not previously disclosed in the
  registration statement or any material change to such
  information in the registration statement;</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however, </I>that paragraphs A(1)(i) and A(1)(ii) do not apply if
  the information required to be included in a post-effective amendment by those
  paragraphs is contained in periodic reports filed by the issuer pursuant to
  section 13 or section 15(d) of the Exchange Act that are incorporated by
  reference herein.
  
  
  <P>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>That, for the purpose of determining any liability under the
  Securities Act, each such post-effective amendment shall be deemed
  to be a new registration statement relating to the securities
  offered herein, and the offering of such securities at that time
  shall be deemed to be the initial <I>bona fide </I>offering thereof.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="1%" nowrap align="right">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To remove from registration by means of a post-effective
  amendment any of the securities being registered which remain unsold
  at the termination of the offering.</TD>
  </TR>
  
  </TABLE>
  
  <P align="left" style="font-size: 10pt"><B>B. </B>The undersigned registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act, each filing of the
  registrant&#146;s annual report pursuant to Section 13(a) or Section 15(d) of the
  Exchange Act (and, where applicable, each filing of an employee benefit plan&#146;s
  annual report pursuant to section 15(d) of the Exchange Act) that is
  incorporated by reference in the Registration Statement shall be deemed to be a
  new registration statement relating to the securities offered herein, and the
  offering of such securities at that time shall be deemed to be the initial <I>bona
  fide </I>offering thereof.
  
  
  <P align="left" style="font-size: 10pt"><B>C. </B>Insofar as indemnification for liabilities arising under the Securities Act
  may be permitted to directors, officers and controlling persons of the
  registrant pursuant to the foregoing provisions, or otherwise, the registrant
  has been advised that in the opinion of the Securities and Exchange Commission
  such indemnification is against public policy as expressed in the Securities
  Act and is, therefore, unenforceable. In the event that a claim for
  indemnification against such liabilities (other than the payment by the
  registrant of expenses incurred or paid by a director, officer or controlling
  person of the registrant in the successful defense of any action, suit or
  proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the registrant will, unless in
  the opinion of its counsel the matter has been settled by controlling
  precedent, submit to a court of appropriate jurisdiction the question whether
  such indemnification by it is against public policy as expressed in the
  Securities Act and will be governed by the final adjudication of such issue.
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>SIGNATURES</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
  the Registrant certifies that it has reasonable grounds to believe that it
  meets all of the requirements for filing on Form S-8 and has duly caused this
  Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the Town of Hopkinton, Commonwealth of
  Massachusetts, July&nbsp;9, 2004.
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top">&nbsp;</TD>
      <TD colspan="3">Caliper Life Sciences, Inc.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD>&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000">/s/ E. Kevin Hrusovsky
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2">E. Kevin Hrusovsky<BR>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2"><I>President and Chief Executive Officer</I>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  
  </TABLE>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  
  </TABLE>
  <!-- link1 "POWER OF ATTORNEY" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>
  
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
  appears below constitutes and appoints E. Kevin Hrusovsky, Peter F. McAree and
  Stephen E. Creager, and each or any one of them, his true and lawful
  attorney-in-fact and agent, with full power of substitution and resubstitution,
  for him and in his name, place and stead, in any and all capacities, to sign
  any and all amendments (including post-effective amendments) to this
  Registration Statement, and to file the same, with all exhibits thereto, and
  other documents in connection therewith, with the Securities and Exchange
  Commission, granting unto said attorneys-in-fact and agents, and each of them,
  full power and authority to do and perform each and every act and thing
  requisite and necessary to be done in connection therewith, as fully to all
  intents and purposes as he might or could do in person, hereby ratifying and
  confirming all that said attorneys-in-fact and agents, or any of them, or their
  or his substitutes or substitute, may lawfully do or cause to be done by virtue
  hereof.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed by the following persons in the
  capacities and on the dates indicated.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="20%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="50%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="25%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Signature</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Title</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Date</B><HR size="1" noshade></TD>
  </TR>
  
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" nowrap valign="top">/s/   E. Kevin Hrusovsky<BR>
  <HR size="1" noshade>
  E. Kevin Hrusovsky</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  President and Chief Executive Officer and<BR>
  Director (<I>Principal Executive Officer</I>)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;9,&nbsp;2004</TD>
  </TR>
  
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/   Peter F. McAree<BR>
  <HR size="1" noshade>
  Peter F. McAree</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Vice President, Finance and Principal<BR>
  Financial Officer<BR>
  (<I>Principal Financial Officer, Principal<BR>
  Accounting Officer</I>)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;9, 2004</TD>
  </TR>
  
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/   Daniel L. Kisner, M.D.<BR>
  <HR size="1" noshade>
  Daniel L. Kisner, M.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Chairman of the Board of Directors
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;9, 2004</TD>
  </TR>
  
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/   David V. Milligan, Ph.D.<BR>
  <HR size="1" noshade>
  David V. Milligan, Ph.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Vice Chairman of the Board of Directors
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;9, 2004</TD>
  </TR>
  
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/   Van Billet<BR>
  <HR size="1" noshade>
  Van Billet</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;9, 2004</TD>
  </TR>
  
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/   Robert C. Bishop<BR>
  <HR size="1" noshade>
  Robert C. Bishop, Ph.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;9, 2004</TD>
  </TR>
  
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">&nbsp;<BR>
  <HR size="1" noshade>
  Edgar J. Cummins</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/   Kathryn Tunstall<BR>
  <HR size="1" noshade>
  Kathryn Tunstall</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;9, 2004</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P align="left" style="font-size: 10pt"><B>EXHIBIT INDEX</B>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="75%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="11%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="84%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Exhibit</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>&nbsp;</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Number</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Description</B></TD>
  </TR>
  
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1(1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3(2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated Bylaws of Caliper.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4(3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen Stock Certificate.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5(4)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, dated as of December&nbsp;18, 2001, between Registrant
  and Wells Fargo Bank Minnesota, N.A., as Rights Agent.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Cooley Godward LLP.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, registered public accounting firm.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Cooley Godward LLP. Reference is made to Exhibit&nbsp;5.1.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney. Reference is made to Signature Page.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">1999 Equity Incentive Plan.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.3(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">1999 Employee Stock Purchase Plan.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.4(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">1999 Non-Employee Directors&#146; Stock Option Plan.</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  <P>
  
  <HR size="1" width="18%" align="left" noshade>
  
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(1)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as Exhibit&nbsp;3.1 to the quarterly report on Form 10-Q for
  the quarter ended March&nbsp;31, 2004, filed May&nbsp;10, 2004, and incorporated
  herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(2)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as Exhibit&nbsp;3.3 to the quarterly report on Form 10-Q for
  the quarter ended June&nbsp;30, 2003, filed August&nbsp;14, 2003, and incorporated
  herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(3)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as Exhibit&nbsp;4.2 to the Registration Statement on Form S-1
  (No.&nbsp;333-88827), as amended, and incorporated herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(4)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as Exhibit&nbsp;99.1 to Current Report on Form 8-K filed
  December&nbsp;19, 2001, and incorporated herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="right">(5)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed as the like-numbered Exhibit to the Registration
  Statement on Form&nbsp;S-8 (No.&nbsp;333-95007), and incorporated herein by
  reference.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  </BODY>
  </HTML>
metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "b51095s8sv8.htm", "description": "CALIPER LIFE SCIENCES, INC.", "secsgml_size_bytes": 51312}]
metadata_filer: {"company-data": {"conformed-name": "CALIPER LIFE SCIENCES INC", "cik": "0001014672", "assigned-sic": "3826", "irs-number": "330675808", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-117273", "film-number": "04908534"}, "business-address": {"street1": "68 ELM STREET", "street2": ".", "city": "HOPKINTON", "state": "MA", "zip": "01748", "phone": "508-435-9500"}, "mail-address": {"street1": "68 ELM STREET", "street2": ".", "city": "HOPKINTON", "state": "MA", "zip": "01748"}, "former-company": {"former-conformed-name": "CALIPER TECHNOLOGIES CORP", "date-changed": "19990921"}}
text: CALIPER LIFE SCIENCES, INC.
  Table of Contents
  As filed with the
  Securities and Exchange Commission on July 9, 2004
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  CALIPER LIFE SCIENCES, INC.
  (Exact name of registrant as specified in its charter)
  Delaware
  (State or other Jurisdiction of
  Incorporation or Organization)
  33-0675808
  (I.R.S. Employer Identification No.)
  68 ELM STREET
  HOPKINTON, MA 01748
  (Address of principal executive offices, including zip code)
  1999 EQUITY INCENTIVE PLAN
  1999 EMPLOYEE STOCK PURCHASE PLAN
  1999 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN
  (Full title of the plans)
  E. Kevin Hrusovsky
  President and Chief Executive Officer
  Caliper Life Sciences, Inc.
  68 Elm Street
  Hopkinton, MA 01748
  (508) 435-9500
  (Name, address, including zip code, and telephone number, including area code,
  of agent for service)
  Copies to:
  Brett D. White, Esq.
  COOLEY GODWARD LLP
  Five Palo Alto Square
  3000 El Camino Real
  Palo Alto, California 94306
  (650) 843-5000
  CALCULATION OF REGISTRATION FEE
  Title of Each Class
  Proposed Maximum
  Proposed Maximum
  of Securities
  Offering
  Aggregate
  Amount of
  to be Registered
  Amount to be Registered
  Price per Share
  Offering Price
  Registration Fee
  Common Stock (par
  value $0.001)
  458,061
  (1)
  $
  4.82
  (2)
  $
  2,205,563.70
  (2)
  $
  279.44
  (2)
  Preferred Share
  Purchase Rights
  458,061
  (3
  )
  (3
  )
  (3
  )
  (1)
  8,845 shares to be registered pursuant to the 1999 Equity Incentive Plan,
  354,079 shares to be registered pursuant to the 1999 Employee Stock
  Purchase Plan and 95,137 shares to be registered pursuant to the 1999
  Non-Employee Directors' Stock Option Plan. This Registration Statement
  shall cover any additional shares of Common Stock which become issuable
  under the plans set forth herein by reason of any stock dividend, stock
  split, recapitalization or any other similar transaction without receipt
  of consideration which results in an increase in the number of shares of
  the Registrant's outstanding Common Stock.
  (2)
  Estimated solely for the purpose of calculating the amount of the
  registration fee pursuant to Rule 457(h). The price per share and
  aggregate offering price of the shares to be offered under these plans
  are based upon the average of the high and low prices of the Registrant's
  Common Stock on July 6, 2004 as reported on the Nasdaq National Market
  (pursuant to Rule 457(c) under the Act) for shares reserved for future
  issuance under the plans.
  (3)
  Preferred Share Purchase Rights, which are attached to the shares of
  Common Stock to be issued but do not trade separately from the shares of
  Common Stock until a triggering event. No additional offering price
  attaches to these rights.
  TABLE OF CONTENTS
  ITEM 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
  ITEM 4. DESCRIPTION OF SECURITIES
  ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
  ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS
  ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED
  ITEM 8. EXHIBITS
  ITEM 9. UNDERTAKINGS
  SIGNATURES
  POWER OF ATTORNEY
  EX-5.1 OPINION OF COOLEY GODWARD LLP
  EX-23.1 CONSENT OF ERNST & YOUNG LLP
  Table of Contents
  ITEM 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
  The following documents filed by Caliper Life Sciences, Inc. (the
  "Company") with the Securities and Exchange Commission are incorporated by
  reference into this Registration Statement:
  (a)
  The Company's Annual Report on Form 10-K for the fiscal year
  ended December 31, 2003 filed on March 15, 2004.
  (b)
  The Company's Quarterly Report on Form 10-Q for the quarter
  ended March 31, 2004 filed on May 10, 2004.
  (c)
  The description of the Company's common stock which is
  contained in the Registration Statement on Form 8-A filed November
  22, 1999, under the Exchange Act, including any amendment or report
  filed for the purpose of updating such description.
  All reports and other documents subsequently filed by the Company pursuant
  to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing
  of a post-effective amendment which indicates that all securities offered have
  been sold or which deregisters all securities then remaining unsold, shall be
  deemed to be incorporated by reference herein and to be a part of this
  registration statement from the date of the filing of such reports and
  documents.
  ITEM 4. DESCRIPTION OF SECURITIES
  The Preferred Share Purchase Rights (the "Rights") are not currently
  registered under the Exchange Act. Each share of Common Stock issued or
  outstanding has attached to it a Right. Each Right entitles the registered
  holder to purchase from Caliper one one-hundredth of a share of Series A Junior
  Participating Preferred Stock, par value $0.001 per share (the "Preferred
  Shares"), at a price of $100.00 per one one-hundredth of a Preferred Share (the
  "Purchase Price"), subject to adjustment. Each one one-hundredth of a share of
  Preferred Shares has designations and powers, preferences and rights, and the
  qualifications, limitations and restrictions which make its value approximately
  equal to the value of a Common Share.
  The Rights are currently evidenced by the stock certificates representing
  the Common Shares outstanding, and no separate Right Certificates, as defined,
  have been distributed. Until the earlier to occur of (i) subject to limited
  exceptions, the date of a public announcement that a person, entity or group of
  affiliated or associated persons have acquired beneficial ownership of 15% or
  more of the outstanding Common Shares (an "Acquiring Person") or (ii) 10
  business days (or such later date as may be determined by action of the Board
  of Directors prior to such time as any person or entity becomes an Acquiring
  Person) following the commencement of, or announcement of an intention to
  commence, a tender offer or exchange offer the consummation of which would
  result in any person or entity becoming an Acquiring Person (the earlier of
  such dates being called the "Distribution Date"), the Rights will be evidenced,
  with respect to any of the Common Share certificates, by such Common Share
  certificate.
  Until the Distribution Date, the Rights will be transferable with and only
  with the Common Shares. As soon as practicable following the Distribution Date,
  separate certificates evidencing the Rights ("Right Certificates") will be
  mailed to holders of record of the Common Shares as of the close of business on
  the Distribution Date and such separate Right Certificates alone will evidence
  the Rights.
  The Rights are not exercisable until the Distribution Date. The Rights
  will expire on December 17, 2011 (the "Final Expiration Date"), unless the
  Rights are earlier redeemed or exchanged by Caliper, in each case, as described
  below. The Rights are protected by customary anti-dilution provisions to
  protect the value of the Rights in the event of a stock dividend on, or a
  subdivision, combination or reclassification of, the Preferred Shares or the
  Common Stock, and in certain other events.
  Preferred Shares purchasable upon exercise of the Rights will not be
  redeemable. Each Preferred Share will be entitled to a minimum preferential
  quarterly dividend payment of $1.00 but will be entitled to an aggregate
  dividend of 100 times the dividend declared per Common Share. In the event of
  liquidation, the holders of the Preferred Shares would be entitled to a minimum
  preferential liquidation payment of $100 per share, but would be
  entitled to receive an aggregate payment equal to 100 times the payment
  made per Common Share. Each Preferred
  Table of Contents
  Share will have 100 votes, voting
  together with the Common Shares. Finally, in the event of any merger,
  consolidation or other transaction in which Common Shares are exchanged, each
  Preferred Share will be entitled to receive 100 times the amount of
  consideration received per Common Share. These rights are protected by
  customary anti-dilution provisions. Because of the nature of the Preferred
  Shares' dividend and liquidation rights, the value of one one-hundredth of a
  Preferred Share should approximate the value of one Common Share. The Preferred
  Shares would rank junior to any other series of Caliper's preferred stock.
  In the event that any person or group of affiliated or associated persons
  becomes an Acquiring Person, proper provision shall be made so that each holder
  of a Right, other than Rights beneficially owned by the Acquiring Person and
  its associates and affiliates (which will thereafter be void), will for a
  60-day period have the right to receive upon exercise that number of Common
  Shares having a market value of two times the exercise price of the Right (or,
  if such number of shares is not and cannot be authorized, Caliper may issue
  Preferred Shares, cash, debt, stock or a combination thereof in exchange for
  the Rights). This right will terminate 60 days after the date on which the
  Rights become nonredeemable (as described below), unless there is an injunction
  or similar obstacle to exercise of the Rights, in which event this right will
  terminate 60 days after the date on which the Rights again become exercisable.
  In the event that Caliper is acquired in a merger or other business
  combination transaction or 50% or more of its consolidated assets or earning
  power are sold to an Acquiring Person, its associates or affiliates or certain
  other persons in which such persons have an interest, proper provision will be
  made so that each holder of a Right will thereafter have the right to receive,
  upon the exercise thereof at the then current exercise price of the Right, that
  number of shares of common stock of the acquiring company which at the time of
  such transaction will have a market value of two times the exercise price of
  the Right.
  At any time after an Acquiring Person becomes an Acquiring Person and
  prior to the acquisition by such Acquiring Person of 50% or more of the
  outstanding Common Shares, the Board of Directors of Caliper may exchange the
  Rights (other than Rights owned by such person or group which have become
  void), in whole or in part, at an exchange ratio of one Common Share, or one
  one-hundredth of a Preferred Share, per Right (or, at the election of Caliper,
  Caliper may issue cash, debt, stock or a combination thereof in exchange for
  the Rights), subject to adjustment.
  At any time prior to the earliest of (i) the day of the first public
  announcement that a person has become an Acquiring Person or (ii) the Final
  Expiration Date, the Board of Directors of Caliper may redeem the Rights in
  whole, but not in part, at a price of $0.01 per Right (the "Redemption Price").
  Following the expiration of the above periods, the Rights become nonredeemable.
  Immediately upon any redemption of the Rights, the right to exercise the Rights
  will terminate and the only right of the holders of Rights will be to receive
  the Redemption Price.
  The terms of the Rights may be amended by the Board of Directors of
  Caliper without the consent of the holders of the Rights, except that from and
  after such time as the rights are distributed no such amendment may adversely
  affect the interest of the holders of the Rights excluding the interests of an
  Acquiring Person.
  Until a Right is exercised, the holder thereof, as such, will have no
  rights as a stockholder of Caliper, including, without limitation, the right to
  vote or to receive dividends.
  The Rights have certain anti-takeover effects. The Rights will cause
  substantial dilution to a person or group that attempts to acquire Caliper on
  terms not approved by Caliper's Board of Directors. The Rights should not
  interfere with any merger or other business combination approved by the Board
  of Directors since the Rights may be amended to permit such acquisition or
  redeemed by Caliper at $0.01 per Right prior to the earliest of (i) the time
  that a person or group has acquired beneficial ownership of 15% or more of the
  Common Shares or (ii) the final expiration date of the rights.
  Table of Contents
  ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
  Not applicable.
  ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS
  Under Section 145 of the Delaware General Corporation Law the Company has
  broad powers to indemnify its directors and officers against liabilities they
  may incur in such capacities, including liabilities under the Securities Act.
  The Company's bylaws require the Company to indemnify its directors and
  executive officers, and permit the Company to indemnify its other officers,
  employees and other agents, to the fullest extent permitted by Delaware law.
  The bylaws also require the Company to advance litigation expenses in the case
  of stockholder derivative actions or other actions, against an undertaking by
  the indemnified party to repay such advances if it is ultimately determined
  that the indemnified party is not entitled to indemnification.
  The Company has entered into indemnity agreements with each of its
  directors and executive officers. Such indemnity agreements contain provisions
  which are in some respects broader than the specific indemnification provisions
  contained in Delaware law. The Company also maintains an insurance policy for
  its directors and executive officers insuring against certain liabilities
  arising in their capacities as such.
  ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED
  Not applicable.
  Table of Contents
  ITEM 8. EXHIBITS
  Exhibit
  Number
  Description
  4.1(1)
  Restated Certificate of Incorporation of the Registrant.
  4.3(2)
  Amended and Restated Bylaws of Caliper.
  4.4(3)
  Specimen Stock Certificate.
  4.5(4)
  Rights Agreement, dated as of December 18, 2001, between Registrant
  and Wells Fargo Bank Minnesota, N.A., as Rights Agent.
  5.1
  Opinion of Cooley Godward LLP.
  23.1
  Consent of Ernst & Young LLP, registered public accounting firm.
  23.2
  Consent of Cooley Godward LLP. Reference is made to Exhibit 5.1.
  24.1
  Power of Attorney. Reference is made to Signature Page.
  99.2(5)
  1999 Equity Incentive Plan.
  99.3(5)
  1999 Employee Stock Purchase Plan.
  99.4(5)
  1999 Non-Employee Directors' Stock Option Plan.
  (1)
  Previously filed as Exhibit 3.1 to the quarterly report on Form 10-Q for
  the quarter ended March 31, 2004, filed May 10, 2004, and incorporated
  herein by reference.
  (2)
  Previously filed as Exhibit 3.3 to the quarterly report on Form 10-Q for
  the quarter ended June 30, 2003, filed August 14, 2003, and incorporated
  herein by reference.
  (3)
  Previously filed as Exhibit 4.2 to the Registration Statement on Form S-1
  (No. 333-88827), as amended, and incorporated herein by reference.
  (4)
  Previously filed as Exhibit 99.1 to Current Report on Form 8-K filed
  December 19, 2001, and incorporated herein by reference.
  (5)
  Previously filed as the like-numbered Exhibit to the Registration
  Statement on Form S-8 (No. 333-95007), and incorporated herein by
  reference.
  Table of Contents
  ITEM 9. UNDERTAKINGS
  A.
  The undersigned registrant hereby undertakes:
  (1)
  To file, during any period in which offers or sales are being
  made, a post-effective amendment to this registration statement:
  (i)
  To include any prospectus required by section
  10(a)(3) of the Securities Act;
  (ii)
  To reflect in the prospectus any facts or events
  arising after the effective date of the registration statement
  (or the most recent post-effective amendment thereof) which,
  individually or in the aggregate, represent a fundamental
  change in the information set forth in the registration
  statement. Notwithstanding the foregoing, any increase or
  decrease in volume of securities offered (if the total dollar
  value of securities offered would not exceed that which was
  registered) and any deviation from the low or high end of the
  estimated maximum offering range may be reflected in the form
  of prospectus filed with the Commission pursuant to Rule
  424(b) (§ 230.424(b) of this chapter) if, in the aggregate,
  the changes in volume and price represent no more than a 20%
  change in the maximum aggregate offering price set forth in
  the "Calculation of Registration Fee" table in the effective
  registration statement.
  (iii)
  To include any material information with respect
  to the plan of distribution not previously disclosed in the
  registration statement or any material change to such
  information in the registration statement;
  Provided, however,
  that paragraphs A(1)(i) and A(1)(ii) do not apply if
  the information required to be included in a post-effective amendment by those
  paragraphs is contained in periodic reports filed by the issuer pursuant to
  section 13 or section 15(d) of the Exchange Act that are incorporated by
  reference herein.
  (2)
  That, for the purpose of determining any liability under the
  Securities Act, each such post-effective amendment shall be deemed
  to be a new registration statement relating to the securities
  offered herein, and the offering of such securities at that time
  shall be deemed to be the initial
  bona fide
  offering thereof.
  (3)
  To remove from registration by means of a post-effective
  amendment any of the securities being registered which remain unsold
  at the termination of the offering.
  B.
  The undersigned registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act, each filing of the
  registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
  Exchange Act (and, where applicable, each filing of an employee benefit plan's
  annual report pursuant to section 15(d) of the Exchange Act) that is
  incorporated by reference in the Registration Statement shall be deemed to be a
  new registration statement relating to the securities offered herein, and the
  offering of such securities at that time shall be deemed to be the initial
  bona
  fide
  offering thereof.
  C.
  Insofar as indemnification for liabilities arising under the Securities Act
  may be permitted to directors, officers and controlling persons of the
  registrant pursuant to the foregoing provisions, or otherwise, the registrant
  has been advised that in the opinion of the Securities and Exchange Commission
  such indemnification is against public policy as expressed in the Securities
  Act and is, therefore, unenforceable. In the event that a claim for
  indemnification against such liabilities (other than the payment by the
  registrant of expenses incurred or paid by a director, officer or controlling
  person of the registrant in the successful defense of any action, suit or
  proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the registrant will, unless in
  the opinion of its counsel the matter has been settled by controlling
  precedent, submit to a court of appropriate jurisdiction the question whether
  such indemnification by it is against public policy as expressed in the
  Securities Act and will be governed by the final adjudication of such issue.
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended,
  the Registrant certifies that it has reasonable grounds to believe that it
  meets all of the requirements for filing on Form S-8 and has duly caused this
  Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the Town of Hopkinton, Commonwealth of
  Massachusetts, July 9, 2004.
  Caliper Life Sciences, Inc.
  By:
  /s/ E. Kevin Hrusovsky
  E. Kevin Hrusovsky
  President and Chief Executive Officer
  Table of Contents
  POWER OF ATTORNEY
  KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
  appears below constitutes and appoints E. Kevin Hrusovsky, Peter F. McAree and
  Stephen E. Creager, and each or any one of them, his true and lawful
  attorney-in-fact and agent, with full power of substitution and resubstitution,
  for him and in his name, place and stead, in any and all capacities, to sign
  any and all amendments (including post-effective amendments) to this
  Registration Statement, and to file the same, with all exhibits thereto, and
  other documents in connection therewith, with the Securities and Exchange
  Commission, granting unto said attorneys-in-fact and agents, and each of them,
  full power and authority to do and perform each and every act and thing
  requisite and necessary to be done in connection therewith, as fully to all
  intents and purposes as he might or could do in person, hereby ratifying and
  confirming all that said attorneys-in-fact and agents, or any of them, or their
  or his substitutes or substitute, may lawfully do or cause to be done by virtue
  hereof.
  Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed by the following persons in the
  capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/   E. Kevin Hrusovsky
  E. Kevin Hrusovsky
  President and Chief Executive Officer and
  Director (
  Principal Executive Officer
  )
  July 9, 2004
  /s/   Peter F. McAree
  Peter F. McAree
  Vice President, Finance and Principal
  Financial Officer
  (
  Principal Financial Officer, Principal
  Accounting Officer
  )
  July 9, 2004
  /s/   Daniel L. Kisner, M.D.
  Daniel L. Kisner, M.D.
  Chairman of the Board of Directors
  July 9, 2004
  /s/   David V. Milligan, Ph.D.
  David V. Milligan, Ph.D.
  Vice Chairman of the Board of Directors
  July 9, 2004
  /s/   Van Billet
  Van Billet
  Director
  July 9, 2004
  /s/   Robert C. Bishop
  Robert C. Bishop, Ph.D.
  Director
  July 9, 2004
  Edgar J. Cummins
  Director
  /s/   Kathryn Tunstall
  Kathryn Tunstall
  Director
  July 9, 2004
  Table of Contents
  EXHIBIT INDEX
  Exhibit
  Number
  Description
  4.1(1)
  Restated Certificate of Incorporation of the Registrant.
  4.3(2)
  Amended and Restated Bylaws of Caliper.
  4.4(3)
  Specimen Stock Certificate.
  4.5(4)
  Rights Agreement, dated as of December 18, 2001, between Registrant
  and Wells Fargo Bank Minnesota, N.A., as Rights Agent.
  5.1
  Opinion of Cooley Godward LLP.
  23.1
  Consent of Ernst & Young LLP, registered public accounting firm.
  23.2
  Consent of Cooley Godward LLP. Reference is made to Exhibit 5.1.
  24.1
  Power of Attorney. Reference is made to Signature Page.
  99.2(5)
  1999 Equity Incentive Plan.
  99.3(5)
  1999 Employee Stock Purchase Plan.
  99.4(5)
  1999 Non-Employee Directors' Stock Option Plan.
  (1)
  Previously filed as Exhibit 3.1 to the quarterly report on Form 10-Q for
  the quarter ended March 31, 2004, filed May 10, 2004, and incorporated
  herein by reference.
  (2)
  Previously filed as Exhibit 3.3 to the quarterly report on Form 10-Q for
  the quarter ended June 30, 2003, filed August 14, 2003, and incorporated
  herein by reference.
  (3)
  Previously filed as Exhibit 4.2 to the Registration Statement on Form S-1
  (No. 333-88827), as amended, and incorporated herein by reference.
  (4)
  Previously filed as Exhibit 99.1 to Current Report on Form 8-K filed
  December 19, 2001, and incorporated herein by reference.
  (5)
  Previously filed as the like-numbered Exhibit to the Registration
  Statement on Form S-8 (No. 333-95007), and incorporated herein by
  reference.