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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 0pt">As filed
  with the Securities and Exchange Commission on January&nbsp;9, 2008
  </DIV>
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: pt"><B>Registration Statement No.&nbsp;333-</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 25%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT<BR>
  UNDER<BR>
  THE SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 25%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 20pt; margin-top: 12pt"><B>INVERNESS MEDICAL INNOVATIONS, INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt"><B>(Exact Name of Registrant as Specified in Its Charter)</B></DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware<BR>
  (State or Other Jurisdiction of <BR>
  Incorporation or Organization)</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-3565120<BR>
  (I.R.S. Employer Identification No.)</B></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>51 Sawyer Road, Suite&nbsp;200<BR>
  Waltham, Massachusetts 02453</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 8pt"><B>(Address of Principal Executive Offices) (Zip Code)</B></DIV>
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Inverness Medical Innovations, Inc. 2001
  Stock Option and Incentive Plan</B>
  </DIV>
  <DIV align="center" style="font-size: 8pt; margin-top: 2pt"><B>(Full Title of Plan)</B>
  </DIV>
  
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 25%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Ron Zwanziger<BR>
  Chairman, President and Chief Executive Officer<BR>
  Inverness Medical Innovations, Inc.<BR>
  51 Sawyer Road, Suite&nbsp;200<BR>
  Waltham, Massachusetts 02453</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt"><B>(Name and Address of Agent For Service)</B></DIV>
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>(781)&nbsp;647-3900<BR>
  (Telephone Number, Including Area Code, of Agent for Service)</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 25%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">With a copy to:<BR>
  <B>Jay McNamara<BR>
  Senior Counsel, Corporate and Finance<BR>
  Inverness Medical Innovations, Inc.<BR>
  51 Sawyer Road, Suite&nbsp;200<BR>
  Waltham, Massachusetts 02453<BR>
  (781)&nbsp;647-3900</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 25%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">CALCULATION OF REGISTRATION FEE
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
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      <TD width="1%">&nbsp;</TD>
      <TD width="9%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of Securities To Be</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount To Be</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed Maximum</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed Maximum</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Registered</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Registered (1)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Offering Price Per Share (2)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Aggregate Offering Price (2)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Registration Fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
                      <TD valign="top" style="border-top: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Common Stock, $.001 par value
  per share
  </DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">3,000,000</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">54.79</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">$</TD>
  
  <TD align="right" valign="top" style="border-top: 1px solid #000000">164,370,000</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">$</TD>
  
  <TD align="right" valign="top" style="border-top: 1px solid #000000">6,459.74</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Pursuant to Rule&nbsp;416 under the Securities Act of 1933, as amended (the &#147;<U>Securities
  Act</U>&#148;), This registration statement also relates to such indeterminate number of additional
  shares of the registrant&#146;s Common Stock as may be required pursuant to the Inverness Medical
  Innovations, Inc. 2001 Stock Option and Incentive Plan, as amended, in the event of a stock
  dividend, stock split, split-up, recapitalization, forfeiture of stock under the plan or other
  similar event.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>This estimate is made pursuant to Rule 457(c) and 457(h)(1) under the Securities Act, solely
  for the purpose of determining the registration fee. The price per share and aggregate
  offering price are based on the average of the high and low prices of the registrant&#146;s Common
  Stock as reported on the American Stock Exchange on January&nbsp;3, 2008.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#000">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;8. Exhibits.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#002">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003">EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b68004imexv5w1.htm">EX-5.1 Opinion of Jay McNamara</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b68004imexv23w1.htm">EX-23.1 Consent of BDO Seidman, LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b68004imexv23w2.htm">EX-23.2 Consent of PricewaterhouseCoopers LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b68004imexv23w3.htm">EX-23.3 Consent of Ernst & Young LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b68004imexv23w4.htm">EX-23.4 Consent of Colby & Company, PLC</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement on Form S-8 is being filed by Inverness Medical Innovations, Inc.
  (the &#147;Company&#148;) for the purpose of registering an additional 3,000,000 shares of common stock, par
  value $.001 per share, to be issued pursuant to the Inverness Medical Innovations, Inc. 2001 Stock
  Option and Incentive Plan, as amended (the &#147;Plan&#148;). The contents of the Company&#146;s Registration
  Statements on Form S-8 (Registration No.&nbsp;333-74032, Registration No.&nbsp;333-90530, Registration No.
  333-106996, Registration No.&nbsp;333-128937 and Registration No.&nbsp;333-139878) relating to the Plan are
  incorporated by reference into this Registration Statement in accordance with General Instruction E
  to Form S-8.
  </DIV>
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the securities the Company is offering is being passed upon by Jay McNamara,
  Esq., Senior Counsel, Corporate &#038; Finance, of the Company. Mr.&nbsp;McNamara owns an aggregate of
  approximately 2,663 shares of common stock of the Company, as well as options to purchase an
  additional 20,079 shares of common stock of the Company.
  </DIV>
  <!-- link2 "Item&nbsp;8. Exhibits." -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8. Exhibits.</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="11%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="84%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B><u>Exhibit&nbsp;No.</u></B>
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B><u>Description</u></B></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>&nbsp;&nbsp;*5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Jay McNamara, Esq, Senior Counsel,
  Corporate &#038; Finance, of Inverness Medical
  Innovations, Inc.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>*23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of BDO Seidman, LLP</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>*23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, Independent
  Registered Public Accounting Firm.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>*23.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, Independent Registered
  Public Accounting Firm.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>*23.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Colby &#038; Company, PLC.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>&nbsp;&nbsp;23.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Jay McNamara, Esq., Senior Counsel,
  Corporate &#038; Finance, of Inverness Medical
  Innovations, Inc. (included in Exhibit&nbsp;5.1)</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>&nbsp;&nbsp;24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (contained in signature page)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">*</TD>
      <TD>&nbsp;</TD>
      <TD>Filed herewith.</TD>
  </TR>
  
  </TABLE>
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->2<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this registration statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the City of Waltham, The Commonwealth of Massachusetts, on January&nbsp;7,
  2008.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left"><B>INVERNESS MEDICAL INNOVATIONS, INC.</B><BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Ron Zwanziger
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Ron Zwanziger&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Chairman, President and Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">POWER OF ATTORNEY
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL BY THESE PRESENTS that each individual whose signature appears below constitutes and
  appoints each of Ron Zwanziger and David Teitel as such person&#146;s true and lawful attorney-in-fact
  and agent with full power of substitution and resubstitution, for such person in such person&#146;s
  name, place and stead, in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this registration statement (or any registration statement for the
  same offering that is to be effective upon filing pursuant to Rule 462(b) under the Securities Act
  of 1933), and to file the same, with all exhibits thereto, and all documents in connection
  therewith, with the Securities and Exchange Commission, granting unto each said attorney-in-fact
  and agent full power and authority to do and perform each and every act and thing requisite and
  necessary to be done in and about the premises, as fully to all intents and purposes as such person
  might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and
  agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by
  virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="20%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 10pt" valign="bottom">
      <TD nowrap align="center"><u><B>Signature</B></u></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><u><B>Title</B></u></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><u><B>Date</B></u></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Ron Zwanziger
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Ron Zwanziger</TD>
      <TD>&nbsp;</TD>
      <TD align="left" nowrap valign="top">
  Chairman, Chief Executive
  Officer and President
  <br>(Principal Executive Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 7, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ David Teitel
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  David Teitel</TD>
      <TD>&nbsp;</TD>
      <TD align="left" nowrap valign="top">
  Chief Financial Officer
  <br>(Principal Financial Officer
  and Principal Accounting
  Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 7, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Carol R. Goldberg
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Carol R. Goldberg</TD>
      <TD>&nbsp;</TD>
      <TD align="left" nowrap valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 7, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Robert P. Khederian
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Robert P. Khederian</TD>
      <TD>&nbsp;</TD>
      <TD align="left" nowrap valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 7, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ John F. Levy
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  John F. Levy</TD>
      <TD>&nbsp;</TD>
      <TD align="left" nowrap valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 7, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Jerry McAleer
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Jerry McAleer, Ph.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left" nowrap valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 7, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ John A. Quelch
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  John A. Quelch</TD>
      <TD>&nbsp;</TD>
      <TD align="left" nowrap valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 7, 2008</TD>
  </TR>
  
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000"></DIV>
  </TD>
      <TD></TD>
      <TD align="left" nowrap valign="top">
  
  </TD>
      <TD></TD>
      <TD align="center" valign="top"></TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">&nbsp;
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  David Scott Ph.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left" nowrap valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January&nbsp;&nbsp;&nbsp;, 2008</TD>
  </TR>
  
  
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000"></DIV>
  </TD>
      <TD></TD>
      <TD align="left" nowrap valign="top">
  
  </TD>
      <TD></TD>
      <TD align="center" valign="top"></TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Peter Townsend
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Peter Townsend</TD>
      <TD>&nbsp;</TD>
      <TD align="left" nowrap valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 7, 2008</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXHIBIT INDEX</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="11%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="84%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B><u>Exhibit&nbsp;No.</u></B>
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B><u>Description</u></B></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>&nbsp;&nbsp;*5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Jay McNamara, Esq, Senior Counsel,
  Corporate &#038; Finance, of Inverness Medical
  Innovations, Inc.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>*23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of BDO Seidman, LLP</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>*23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, Independent
  Registered Public Accounting Firm.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>*23.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, Independent Registered
  Public Accounting Firm.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>*23.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Colby &#038; Company, PLC.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>&nbsp;&nbsp;23.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Jay McNamara, Esq., Senior Counsel,
  Corporate &#038; Finance, of Inverness Medical
  Innovations, Inc. (included in Exhibit&nbsp;5.1)</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B></B>&nbsp;&nbsp;24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&#151;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (contained in signature page)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">*</TD>
      <TD>&nbsp;</TD>
      <TD>Filed herewith.</TD>
  </TR>
  
  </TABLE>
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  As filed
  with the Securities and Exchange Commission on January 9, 2008
  Registration Statement No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  INVERNESS MEDICAL INNOVATIONS, INC.
  (Exact Name of Registrant as Specified in Its Charter)
  Delaware
  (State or Other Jurisdiction of
  Incorporation or Organization)
  04-3565120
  (I.R.S. Employer Identification No.)
  51 Sawyer Road, Suite 200
  Waltham, Massachusetts 02453
  (Address of Principal Executive Offices) (Zip Code)
  Inverness Medical Innovations, Inc. 2001
  Stock Option and Incentive Plan
  (Full Title of Plan)
  Ron Zwanziger
  Chairman, President and Chief Executive Officer
  Inverness Medical Innovations, Inc.
  51 Sawyer Road, Suite 200
  Waltham, Massachusetts 02453
  (Name and Address of Agent For Service)
  (781) 647-3900
  (Telephone Number, Including Area Code, of Agent for Service)
  With a copy to:
  Jay McNamara
  Senior Counsel, Corporate and Finance
  Inverness Medical Innovations, Inc.
  51 Sawyer Road, Suite 200
  Waltham, Massachusetts 02453
  (781) 647-3900
  CALCULATION OF REGISTRATION FEE
  Title of Securities To Be
  Amount To Be
  Proposed Maximum
  Proposed Maximum
  Amount of
  Registered
  Registered (1)
  Offering Price Per Share (2)
  Aggregate Offering Price (2)
  Registration Fee
  Common Stock, $.001 par value
  per share
  3,000,000
  $
  54.79
  $
  164,370,000
  $
  6,459.74
  (1)
  Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "
  Securities
  Act
  "), This registration statement also relates to such indeterminate number of additional
  shares of the registrant's Common Stock as may be required pursuant to the Inverness Medical
  Innovations, Inc. 2001 Stock Option and Incentive Plan, as amended, in the event of a stock
  dividend, stock split, split-up, recapitalization, forfeiture of stock under the plan or other
  similar event.
  (2)
  This estimate is made pursuant to Rule 457(c) and 457(h)(1) under the Securities Act, solely
  for the purpose of determining the registration fee. The price per share and aggregate
  offering price are based on the average of the high and low prices of the registrant's Common
  Stock as reported on the American Stock Exchange on January 3, 2008.
  TABLE OF CONTENTS
  Item 5. Interests of Named Experts and Counsel.
  Item 8. Exhibits.
  SIGNATURES
  EXHIBIT INDEX
  EX-5.1 Opinion of Jay McNamara
  EX-23.1 Consent of BDO Seidman, LLP
  EX-23.2 Consent of PricewaterhouseCoopers LLP
  EX-23.3 Consent of Ernst & Young LLP
  EX-23.4 Consent of Colby & Company, PLC
  Table of Contents
  This Registration Statement on Form S-8 is being filed by Inverness Medical Innovations, Inc.
  (the "Company") for the purpose of registering an additional 3,000,000 shares of common stock, par
  value $.001 per share, to be issued pursuant to the Inverness Medical Innovations, Inc. 2001 Stock
  Option and Incentive Plan, as amended (the "Plan"). The contents of the Company's Registration
  Statements on Form S-8 (Registration No. 333-74032, Registration No. 333-90530, Registration No.
  333-106996, Registration No. 333-128937 and Registration No. 333-139878) relating to the Plan are
  incorporated by reference into this Registration Statement in accordance with General Instruction E
  to Form S-8.
  Item 5. Interests of Named Experts and Counsel.
  The validity of the securities the Company is offering is being passed upon by Jay McNamara,
  Esq., Senior Counsel, Corporate & Finance, of the Company. Mr. McNamara owns an aggregate of
  approximately 2,663 shares of common stock of the Company, as well as options to purchase an
  additional 20,079 shares of common stock of the Company.
  Item 8. Exhibits.
  Exhibit No.
  Description
  *5.1
  —
  Opinion of Jay McNamara, Esq, Senior Counsel,
  Corporate & Finance, of Inverness Medical
  Innovations, Inc.
  *23.1
  —
  Consent of BDO Seidman, LLP
  *23.2
  —
  Consent of PricewaterhouseCoopers LLP, Independent
  Registered Public Accounting Firm.
  *23.3
  —
  Consent of Ernst & Young LLP, Independent Registered
  Public Accounting Firm.
  *23.4
  —
  Consent of Colby & Company, PLC.
  23.5
  —
  Consent of Jay McNamara, Esq., Senior Counsel,
  Corporate & Finance, of Inverness Medical
  Innovations, Inc. (included in Exhibit 5.1)
  24.1
  —
  Power of Attorney (contained in signature page)
  *
  Filed herewith.
  2
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this registration statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the City of Waltham, The Commonwealth of Massachusetts, on January 7,
  2008.
  INVERNESS MEDICAL INNOVATIONS, INC.
  By:
  /s/ Ron Zwanziger
  Ron Zwanziger
  Chairman, President and Chief Executive Officer
  POWER OF ATTORNEY
  KNOW ALL BY THESE PRESENTS that each individual whose signature appears below constitutes and
  appoints each of Ron Zwanziger and David Teitel as such person's true and lawful attorney-in-fact
  and agent with full power of substitution and resubstitution, for such person in such person's
  name, place and stead, in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this registration statement (or any registration statement for the
  same offering that is to be effective upon filing pursuant to Rule 462(b) under the Securities Act
  of 1933), and to file the same, with all exhibits thereto, and all documents in connection
  therewith, with the Securities and Exchange Commission, granting unto each said attorney-in-fact
  and agent full power and authority to do and perform each and every act and thing requisite and
  necessary to be done in and about the premises, as fully to all intents and purposes as such person
  might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and
  agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by
  virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Ron Zwanziger
  Ron Zwanziger
  Chairman, Chief Executive
  Officer and President
  (Principal Executive Officer)
  January 7, 2008
  /s/ David Teitel
  David Teitel
  Chief Financial Officer
  (Principal Financial Officer
  and Principal Accounting
  Officer)
  January 7, 2008
  /s/ Carol R. Goldberg
  Carol R. Goldberg
  Director
  January 7, 2008
  /s/ Robert P. Khederian
  Robert P. Khederian
  Director
  January 7, 2008
  /s/ John F. Levy
  John F. Levy
  Director
  January 7, 2008
  /s/ Jerry McAleer
  Jerry McAleer, Ph.D.
  Director
  January 7, 2008
  /s/ John A. Quelch
  John A. Quelch
  Director
  January 7, 2008
  David Scott Ph.D.
  Director
  January   , 2008
  /s/ Peter Townsend
  Peter Townsend
  Director
  January 7, 2008
  Table of Contents
  EXHIBIT INDEX
  Exhibit No.
  Description
  *5.1
  —
  Opinion of Jay McNamara, Esq, Senior Counsel,
  Corporate & Finance, of Inverness Medical
  Innovations, Inc.
  *23.1
  —
  Consent of BDO Seidman, LLP
  *23.2
  —
  Consent of PricewaterhouseCoopers LLP, Independent
  Registered Public Accounting Firm.
  *23.3
  —
  Consent of Ernst & Young LLP, Independent Registered
  Public Accounting Firm.
  *23.4
  —
  Consent of Colby & Company, PLC.
  23.5
  —
  Consent of Jay McNamara, Esq., Senior Counsel,
  Corporate & Finance, of Inverness Medical
  Innovations, Inc. (included in Exhibit 5.1)
  24.1
  —
  Power of Attorney (contained in signature page)
  *
  Filed herewith.