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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <P align="center" style="font-size: 10pt">As filed with the Securities and Exchange Commission on July&nbsp;15, 2005
  
  
  
  <P align="right" style="font-size: 10pt; margin-right: 10%">REGISTRATION NO. 333 -
  
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B></DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  
  <P align="center" style="font-size: 18pt"><B>FORM S-8</B>
  
  
  <DIV align="center" style="font-size: 12pt"><B>REGISTRATION STATEMENT</B></DIV>
  
  
  <DIV align="center" style="font-size: 12pt"><B>under the</B></DIV>
  
  
  <DIV align="center" style="font-size: 12pt"><B>SECURITIES ACT OF 1933</B></DIV>
  
  
  <DIV align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  
  <P align="center" style="font-size: 24pt"><B>OXiGENE, INC.</B>
  
  
  <DIV align="center" style="font-size: 10pt">(<I>Exact Name of Registrant as Specified in Its Charter</I>)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B><BR>
  (<I>State or Other Jurisdiction<BR>
  of Incorporation or Organization</I>)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>13-3679168</B><BR>
  (<I>I.R.S. Employer<BR>
  Identification No.</I>)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><B>230 Third Avenue<BR>
  Waltham, MA 02451</B><BR>
  (<I>Address, Including Zip Code, of Principal Executive Offices</I>)
  
  
  
  <P align="center" style="font-size: 10pt"><B>OXiGENE, INC. 2005 STOCK PLAN</B><BR>
  <I>(Full Titles of the Plans)</I>
  
  
  
  <P align="center" style="font-size: 10pt"><B>Frederick W. Driscoll<BR>
  OXiGENE, Inc.<BR>
  230 Third Avenue<BR>
  Waltham, MA 02451<BR>
  781-547-5900</B><BR>
  (<I>Name, Address and Telephone Number, Including<BR>
  Area Code, of Agent For Service</I>)
  
  
  <DIV align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  
  
  <P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="33%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
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      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
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      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="21" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Maximum</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Maximum</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount to be</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Offering Price</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Aggregate</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Securities to be Registered</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Registered<SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Per Share<SUP style="font-size: 85%; vertical-align: text-top"> (2)</SUP></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Offering Price<SUP style="font-size: 85%; vertical-align: text-top"> (2)</SUP></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Registration Fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
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      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
                      <TD valign="top" style="border-top: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Common Stock, $0.01 par value
  </DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap colspan="3" align="center" valign="top" style="border-top: 1px solid #000000">2,500,000 shares
  </TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">4.43</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">11,075,000</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="center" valign="top" style="border-top: 1px solid #000000">$1,303.53<BR></TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD valign="top" style="border-top: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Rights to purchase Common
  Stock
  </DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">(3</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">(3</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">(3</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="center" valign="top" style="border-top: 1px solid #000000">None</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="21" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top">
      <TD width="3%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="96%">The number of common shares, par value $0.01 per share (&#147;Common Stock&#148;), stated above
  consists of the aggregate number of shares which may be sold upon the exercise of options or
  issuance of stock awards which may hereafter be granted under the OXiGENE, Inc. 2005 Stock
  Plan (the &#147;Stock Plan&#148;). The maximum number of shares which may be sold upon the exercise of
  such options or issuance of stock awards granted under the Stock Plan are subject to
  adjustment in accordance with certain anti-dilution and other provisions of the Stock Plan.
  Accordingly, pursuant to Rule&nbsp;416 under the Securities Act of 1933, as amended (the
  &#147;Securities Act&#148;), this Registration Statement covers, in addition to the number of shares
  stated above, an indeterminate number of shares which may be subject to grant or otherwise
  issuable after the operation of any such anti-dilution and other provisions.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="3%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="96%">This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(c) and (h)&nbsp;under the Securities Act as follows: (i)&nbsp;in the case
  of shares of Common Stock which may be purchased upon exercise of outstanding options, the fee
  is calculated on the basis of the price at which the options may be exercised; and (ii)&nbsp;in the
  case of shares of Common Stock for which options and stock awards have not yet been granted
  and the price of which is therefore unknown, the fee is calculated on the basis of the average
  of the high and low sale prices per share of the Common Stock on the Nasdaq National Market as
  of a date (July&nbsp;11, 2005) within five business days prior to filing this Registration
  Statement.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="3%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="96%">No separate consideration will be received for the Rights.</TD>
  </TR>
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><U>EXPLANATORY NOTE</U>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with the instructional Note to Part&nbsp;I of Form S-8 as promulgated by the
  Securities and Exchange Commission, the information specified by Part&nbsp;I of Form S-8 has been
  omitted from this Registration Statement on Form S-8 for offers of Common Stock pursuant to the
  Stock Plan.
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Certain Documents by Reference</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;4. Description of Securities</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;7. Exemption from Registration Claimed</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;8. Exhibits</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;9. Undertakings</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#008">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#009"> INDEX TO EXHIBITS FILED WITH FORM S-8 REGISTRATION STATEMENT</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55882oiexv4w4.txt">Ex-4.4 Certificate of Amendment of Restated Certificate of Inc.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55882oiexv5.txt">Ex-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55882oiexv23w2.txt">Ex-23.2 Consent of Ernst & Young LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link1 "PART II" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>PART II</B>
  
  
  
  <P align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  
  <!-- link2 "Item&nbsp;3. Incorporation of Certain Documents by Reference" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><U>Item&nbsp;3. Incorporation of Certain Documents by Reference</U>.
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31, 2004
  filed on March&nbsp;15, 2005.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Amendment No.&nbsp;1 on Form 10-K/A to the Registrant&#146;s Annual Report on Form 10-K for the
  fiscal year ended December&nbsp;31, 2004 filed on April&nbsp;29, 2005.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;The Registrant&#146;s Quarterly Report on Form 10-Q for the quarter ended March&nbsp;31, 2005 filed
  on April&nbsp;29, 2005.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Amendment No.&nbsp;1 on Form 10-Q/A to the Registrant&#146;s Quarterly Report on Form 10-Q for the
  quarter ended March&nbsp;31, 2005 filed on June&nbsp;7, 2005.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;The Registrant&#146;s Current Report on Form 8-K filed on March&nbsp;7, 2005.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;The Registrant&#146;s Current Report on Form 8-K filed on March&nbsp;30, 2005.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)&nbsp;The Registrant&#146;s Current Report on Form 8-K filed on July&nbsp;11, 2005.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h)&nbsp;The description of the Common Stock contained in the Registrant&#146;s Registration Statement
  on Form 8-A (File No.&nbsp;000-21990) filed under the Securities Exchange Act of 1934, as amended (the
  &#147;Exchange Act&#148;), with the Commission on June&nbsp;25, 1993, including any amendment or report filed for
  the purpose of updating such description.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;The description of the Rights under the Stockholder Rights Agreement (which are currently
  transferred with the Registrant&#146;s Common Stock) contained in the Registrant&#146;s Registration
  Statement on Form 8-A12G (File No.&nbsp;000-21990) filed under the Exchange Act with the Commission on
  March&nbsp;30, 2005, including any amendment or report filed for the purpose of updating such
  description.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective
  amendment which indicates that all securities offered hereby have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such reports and documents.
  
  <!-- link2 "Item&nbsp;4. Description of Securities" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><U>Item&nbsp;4. Description of Securities</U>.
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><U>Item&nbsp;5. Interests of Named Experts and Counsel</U>.
  
  
  
  <P align="center" style="font-size: 10pt">1
  </DIV>
  
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  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm, their families
  and trusts for their benefit own an aggregate of approximately 373 shares of Common Stock of the
  Registrant.
  
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><U>Item&nbsp;6. Indemnification of Directors and Officers</U>.
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporated by reference from the Registrant&#146;s Registration Statement on Form&nbsp;S-3, No.
  333-109433 filed on October&nbsp;3, 2003.
  
  <!-- link2 "Item&nbsp;7. Exemption from Registration Claimed" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><U>Item&nbsp;7. Exemption from Registration Claimed</U>.
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><U>Item&nbsp;8. Exhibits</U>.
  
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(4.1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Form of Common Stock Certificate (Filed as Exhibit to the Registrant&#146;s
  Registration Statement on Form S-1, as amended, No.&nbsp;033-64968, and incorporated herein
  by reference).</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(4.2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Restated Certificate of Incorporation of the Registrant (Filed as Exhibit to
  the Registrant&#146;s Registration Statement on Form S-1, as amended, No.&nbsp;033-64968, and
  incorporated herein by reference).</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(4.3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Certificate of Amendment of Restated Certificate of Incorporation of the
  Registrant (Filed as Exhibit to the Registrant&#146;s Annual Report of Form 10-K for the
  fiscal year ended December&nbsp;31, 1996, No.&nbsp;000-21990, and incorporated herein by
  reference).</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(4.4)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Certificate of Amendment of Restated Certificate of Incorporation of the
  Registrant.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(4.5)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Amended and Restated By-Laws of the Registrant (Filed as Exhibit to the
  Registrant&#146;s Quarterly Report on Form 10-Q for the quarter ended March&nbsp;31, 2004, No.
  000-21990, and incorporated herein by reference).</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(4.6)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Stockholder Rights Agreement (Filed as Exhibit to the Registrant&#146;s
  Registration Statement on Form 8-A12G, File No.&nbsp;000-21990, and incorporated herein by
  reference).</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(5)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the
  legality of shares being registered.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(23.1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion
  of counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(23.2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Consent of Ernst &#038; Young LLP.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(24)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Power of Attorney to file future amendments (set forth on the signature page of
  this Registration Statement).</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(99.1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>OXiGENE, Inc. 2005 Stock Plan (Filed as Exhibit to the Registrant&#146;s Current Report on
  Form 8-K, File No.&nbsp;000-21990, and incorporated herein by reference).</TD>
  </TR>
  
  </TABLE>
  
  <P align="center" style="font-size: 10pt">2
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  
  </TABLE>
  
  <!-- link2 "Item&nbsp;9. Undertakings" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><U>Item&nbsp;9. Undertakings</U>.
  
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes:</TD>
  </TR>
  
  </TABLE>
  
  
  
  <P align="left" style="margin-left:4%; font-size: 10pt">(1)&nbsp;To file, during any period in which offers or sales are being made, a post-effective
  amendment to this Registration Statement:
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of the Securities
  Act of 1933;
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represents a fundamental
  change in the information set forth in the Registration Statement. Notwithstanding
  the foregoing, any increase or decrease in volume of securities offered (if the
  total dollar value of securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated maximum offering range
  may be reflected in the form of prospectus filed with the Commission pursuant to
  Rule 424(b) if, in the aggregate, the changes in volume and price represent no more
  than a 20% change in the maximum aggregate offering price set forth in the
  &#147;Calculation of Registration Fee&#148; table in the effective Registration Statement.
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or any material
  change to such information in the Registration Statement;
  
  
  
  <P align="left" style="margin-left:4%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  Registration Statement is on Form S-3, Form S-8 or Form F-3, and the information required to
  be included in a post-effective amendment by those paragraphs is contained in periodic
  reports filed with or furnished to the Commission by the Registrant pursuant to Section&nbsp;13
  or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference
  in this Registration Statement.
  
  
  
  <P align="left" style="margin-left:4%; font-size: 10pt">(2)&nbsp;That, for the purpose of determining any liability under the Securities Act of 1933,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  
  
  
  <P align="left" style="margin-left:4%; font-size: 10pt">(3)&nbsp;To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant&#146;s annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by
  reference in this Registration Statement shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange</TD>
  </TR>
  
  </TABLE>
  
  <P align="center" style="font-size: 10pt">3
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Commission such indemnification is against public policy as expressed in the Act and is,
  therefore, unenforceable. In the event that a claim for indemnification against such
  liabilities (other than the payment by the Registrant of expenses incurred or paid by a
  director, officer or controlling person of the Registrant in the successful defense of any
  action, suit or proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.</TD>
  </TR>
  
  </TABLE>
  
  <P align="center" style="font-size: 10pt">4
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  
  </TABLE>
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>SIGNATURES</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>The Registrant</I>. Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
  the undersigned, thereunto duly authorized, in Waltham, Massachusetts on July&nbsp;15, 2005.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="48%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="16%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" valign="top" align="left"><B>OXiGENE, </B><FONT style="font-variant: SMALL-CAPS"><B>Inc.</B></FONT></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">/s/ Frederick W. Driscoll</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>Frederick W. Driscoll</B></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>President and Chief Executive Officer</B></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Frederick W. Driscoll and
  James B. Murphy, and each of them singly, his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them
  singly, for him and in his name, place and stead, and in any and all capacities, to sign any and
  all amendments (including post-effective amendments) to this Registration Statement on Form S-8 of
  OXiGENE, Inc., and to file the same, with all exhibits thereto and other documents in connection
  therewith, with the Securities and Exchange Commission, granting to the attorneys-in-fact and
  agents, and each of them, full power and authority to do and perform each and every act and thing
  requisite or necessary to be done in or about the premises, as full to all intents and purposes as
  he might or could do in person, hereby ratifying and confirming all that the attorneys-in-fact and
  agents or any of each of them or their substitute may lawfully do or cause to be done by virtue
  hereof.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="28%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top" style="border-bottom: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">/s/ Joel-Tomas Citron
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Chairman of the Board and Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;15, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Joel-Tomas Citron</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top" style="border-bottom: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">/s/ Frederick W. Driscoll
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" nowrap>President, Chief Executive
  Officer and Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;15, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Frederick W. Driscoll
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(Principal executive officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top" style="border-bottom: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">/s/ James B. Murphy
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Chief Financial Officer</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;15, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">James B. Murphy
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" nowrap>(Principal financial officer and principal accounting officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top" style="border-bottom: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">/s/ Arthur B. Laffer
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;15, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Arthur B. Laffer</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top" style="border-bottom: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">/s/ William N. Shiebler
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;15, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">William N. Shiebler</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">5
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="28%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top" style="border-bottom: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">/s/ Per-Olof S&#246;derberg
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;15, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Per-Olof S&#246;derberg</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top" style="border-bottom: 1px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">/s/ J. Richard Zecher
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">July&nbsp;15, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">J. Richard Zecher</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">6
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P align="center" style="font-size: 10pt"><B>OXiGENE, Inc.</B>
  
  
  <!-- link1 " INDEX TO EXHIBITS FILED WITH FORM S-8 REGISTRATION STATEMENT" -->
  <DIV align="left"><A NAME="009"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>INDEX TO EXHIBITS FILED WITH<BR>
  FORM S-8 REGISTRATION STATEMENT</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="6%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="92%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Certificate (Filed as Exhibit to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended, No.
  033-64968, and incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant (Filed as
  Exhibit to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as
  amended, No.&nbsp;033-64968, and incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Restated Certificate of Incorporation of
  the Registrant (Filed as Exhibit to the Registrant&#146;s Annual Report
  of Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 1996, No.
  000-21990, and incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.4)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Restated Certificate of Incorporation of
  the Registrant.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated By-Laws of the Registrant (Filed as Exhibit to
  the Registrant&#146;s Quarterly Report on Form&nbsp;10-Q for the quarter ended
  March&nbsp;31, 2004, No.&nbsp;000-21990, and incorporated herein by
  reference).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.6)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Stockholder Rights Agreement (Filed as Exhibit to the Registrant&#146;s
  Registration Statement on Form&nbsp;8-A12G, File No.&nbsp;000-21990, and
  incorporated herein by reference).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to
  the legality of shares being registered.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  (included in opinion of counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(24)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney to file future amendments (set forth on the
  signature page of this Registration Statement).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">OXiGENE, Inc. 2005 Stock Plan (Filed as Exhibit to the Registrant&#146;s
  Current Report on Form&nbsp;8-K, File No.&nbsp;000-21990, and incorporated
  herein by reference).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">7
  </DIV>
  
  </BODY>
  </HTML>
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metadata_filer: {"company-data": {"conformed-name": "OXIGENE INC", "cik": "0000908259", "assigned-sic": "2836", "irs-number": "133679168", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-126636", "film-number": "05957747"}, "business-address": {"street1": "321 ARSENAL STREET", "city": "WATERTOWN", "state": "MA", "zip": "02472", "phone": "6176737800"}}
text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on July 15, 2005
  REGISTRATION NO. 333 -
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  under the
  SECURITIES ACT OF 1933
  OXiGENE, INC.
  (
  Exact Name of Registrant as Specified in Its Charter
  )
  Delaware
  (
  State or Other Jurisdiction
  of Incorporation or Organization
  )
  13-3679168
  (
  I.R.S. Employer
  Identification No.
  )
  230 Third Avenue
  Waltham, MA 02451
  (
  Address, Including Zip Code, of Principal Executive Offices
  )
  OXiGENE, INC. 2005 STOCK PLAN
  (Full Titles of the Plans)
  Frederick W. Driscoll
  OXiGENE, Inc.
  230 Third Avenue
  Waltham, MA 02451
  781-547-5900
  (
  Name, Address and Telephone Number, Including
  Area Code, of Agent For Service
  )
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  Maximum
  Maximum
  Title of
  Amount to be
  Offering Price
  Aggregate
  Amount of
  Securities to be Registered
  Registered
  (1)
  Per Share
  (2)
  Offering Price
  (2)
  Registration Fee
  Common Stock, $0.01 par value
  2,500,000 shares
  $
  4.43
  $
  11,075,000
  $1,303.53
  Rights to purchase Common
  Stock
  (3
  )
  (3
  )
  (3
  )
  None
  (1)
  The number of common shares, par value $0.01 per share ("Common Stock"), stated above
  consists of the aggregate number of shares which may be sold upon the exercise of options or
  issuance of stock awards which may hereafter be granted under the OXiGENE, Inc. 2005 Stock
  Plan (the "Stock Plan"). The maximum number of shares which may be sold upon the exercise of
  such options or issuance of stock awards granted under the Stock Plan are subject to
  adjustment in accordance with certain anti-dilution and other provisions of the Stock Plan.
  Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as amended (the
  "Securities Act"), this Registration Statement covers, in addition to the number of shares
  stated above, an indeterminate number of shares which may be subject to grant or otherwise
  issuable after the operation of any such anti-dilution and other provisions.
  (2)
  This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(c) and (h) under the Securities Act as follows: (i) in the case
  of shares of Common Stock which may be purchased upon exercise of outstanding options, the fee
  is calculated on the basis of the price at which the options may be exercised; and (ii) in the
  case of shares of Common Stock for which options and stock awards have not yet been granted
  and the price of which is therefore unknown, the fee is calculated on the basis of the average
  of the high and low sale prices per share of the Common Stock on the Nasdaq National Market as
  of a date (July 11, 2005) within five business days prior to filing this Registration
  Statement.
  (3)
  No separate consideration will be received for the Rights.
  Table of Contents
  EXPLANATORY NOTE
  In accordance with the instructional Note to Part I of Form S-8 as promulgated by the
  Securities and Exchange Commission, the information specified by Part I of Form S-8 has been
  omitted from this Registration Statement on Form S-8 for offers of Common Stock pursuant to the
  Stock Plan.
  TABLE OF CONTENTS
  PART II
  Item 3. Incorporation of Certain Documents by Reference
  Item 4. Description of Securities
  Item 5. Interests of Named Experts and Counsel
  Item 6. Indemnification of Directors and Officers
  Item 7. Exemption from Registration Claimed
  Item 8. Exhibits
  Item 9. Undertakings
  SIGNATURES
  INDEX TO EXHIBITS FILED WITH FORM S-8 REGISTRATION STATEMENT
  Ex-4.4 Certificate of Amendment of Restated Certificate of Inc.
  Ex-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  Ex-23.2 Consent of Ernst & Young LLP
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference
  .
  The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  (a) The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2004
  filed on March 15, 2005.
  (b) Amendment No. 1 on Form 10-K/A to the Registrant's Annual Report on Form 10-K for the
  fiscal year ended December 31, 2004 filed on April 29, 2005.
  (c) The Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2005 filed
  on April 29, 2005.
  (d) Amendment No. 1 on Form 10-Q/A to the Registrant's Quarterly Report on Form 10-Q for the
  quarter ended March 31, 2005 filed on June 7, 2005.
  (e) The Registrant's Current Report on Form 8-K filed on March 7, 2005.
  (f) The Registrant's Current Report on Form 8-K filed on March 30, 2005.
  (g) The Registrant's Current Report on Form 8-K filed on July 11, 2005.
  (h) The description of the Common Stock contained in the Registrant's Registration Statement
  on Form 8-A (File No. 000-21990) filed under the Securities Exchange Act of 1934, as amended (the
  "Exchange Act"), with the Commission on June 25, 1993, including any amendment or report filed for
  the purpose of updating such description.
  (i) The description of the Rights under the Stockholder Rights Agreement (which are currently
  transferred with the Registrant's Common Stock) contained in the Registrant's Registration
  Statement on Form 8-A12G (File No. 000-21990) filed under the Exchange Act with the Commission on
  March 30, 2005, including any amendment or report filed for the purpose of updating such
  description.
  All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective
  amendment which indicates that all securities offered hereby have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such reports and documents.
  Item 4. Description of Securities
  .
  Not applicable.
  Item 5. Interests of Named Experts and Counsel
  .
  1
  Table of Contents
  The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm, their families
  and trusts for their benefit own an aggregate of approximately 373 shares of Common Stock of the
  Registrant.
  Item 6. Indemnification of Directors and Officers
  .
  Incorporated by reference from the Registrant's Registration Statement on Form S-3, No.
  333-109433 filed on October 3, 2003.
  Item 7. Exemption from Registration Claimed
  .
  Not applicable.
  Item 8. Exhibits
  .
  (4.1)
  Form of Common Stock Certificate (Filed as Exhibit to the Registrant's
  Registration Statement on Form S-1, as amended, No. 033-64968, and incorporated herein
  by reference).
  (4.2)
  Restated Certificate of Incorporation of the Registrant (Filed as Exhibit to
  the Registrant's Registration Statement on Form S-1, as amended, No. 033-64968, and
  incorporated herein by reference).
  (4.3)
  Certificate of Amendment of Restated Certificate of Incorporation of the
  Registrant (Filed as Exhibit to the Registrant's Annual Report of Form 10-K for the
  fiscal year ended December 31, 1996, No. 000-21990, and incorporated herein by
  reference).
  (4.4)
  Certificate of Amendment of Restated Certificate of Incorporation of the
  Registrant.
  (4.5)
  Amended and Restated By-Laws of the Registrant (Filed as Exhibit to the
  Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2004, No.
  000-21990, and incorporated herein by reference).
  (4.6)
  Stockholder Rights Agreement (Filed as Exhibit to the Registrant's
  Registration Statement on Form 8-A12G, File No. 000-21990, and incorporated herein by
  reference).
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the
  legality of shares being registered.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion
  of counsel filed as Exhibit 5).
  (23.2)
  Consent of Ernst & Young LLP.
  (24)
  Power of Attorney to file future amendments (set forth on the signature page of
  this Registration Statement).
  (99.1)
  OXiGENE, Inc. 2005 Stock Plan (Filed as Exhibit to the Registrant's Current Report on
  Form 8-K, File No. 000-21990, and incorporated herein by reference).
  2
  Table of Contents
  Item 9. Undertakings
  .
  (a)
  The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made, a post-effective
  amendment to this Registration Statement:
  (i) To include any prospectus required by Section 10(a)(3) of the Securities
  Act of 1933;
  (ii) To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represents a fundamental
  change in the information set forth in the Registration Statement. Notwithstanding
  the foregoing, any increase or decrease in volume of securities offered (if the
  total dollar value of securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated maximum offering range
  may be reflected in the form of prospectus filed with the Commission pursuant to
  Rule 424(b) if, in the aggregate, the changes in volume and price represent no more
  than a 20% change in the maximum aggregate offering price set forth in the
  "Calculation of Registration Fee" table in the effective Registration Statement.
  (iii) To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or any material
  change to such information in the Registration Statement;
  Provided, however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  Registration Statement is on Form S-3, Form S-8 or Form F-3, and the information required to
  be included in a post-effective amendment by those paragraphs is contained in periodic
  reports filed with or furnished to the Commission by the Registrant pursuant to Section 13
  or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference
  in this Registration Statement.
  (2) That, for the purpose of determining any liability under the Securities Act of 1933,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by
  reference in this Registration Statement shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (c)
  Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange
  3
  Table of Contents
  Commission such indemnification is against public policy as expressed in the Act and is,
  therefore, unenforceable. In the event that a claim for indemnification against such
  liabilities (other than the payment by the Registrant of expenses incurred or paid by a
  director, officer or controlling person of the Registrant in the successful defense of any
  action, suit or proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.
  4
  Table of Contents
  SIGNATURES
  The Registrant
  . Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
  the undersigned, thereunto duly authorized, in Waltham, Massachusetts on July 15, 2005.
  OXiGENE,
  Inc.
  By
  /s/ Frederick W. Driscoll
  Frederick W. Driscoll
  President and Chief Executive Officer
  Each person whose signature appears below constitutes and appoints Frederick W. Driscoll and
  James B. Murphy, and each of them singly, his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them
  singly, for him and in his name, place and stead, and in any and all capacities, to sign any and
  all amendments (including post-effective amendments) to this Registration Statement on Form S-8 of
  OXiGENE, Inc., and to file the same, with all exhibits thereto and other documents in connection
  therewith, with the Securities and Exchange Commission, granting to the attorneys-in-fact and
  agents, and each of them, full power and authority to do and perform each and every act and thing
  requisite or necessary to be done in or about the premises, as full to all intents and purposes as
  he might or could do in person, hereby ratifying and confirming all that the attorneys-in-fact and
  agents or any of each of them or their substitute may lawfully do or cause to be done by virtue
  hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Joel-Tomas Citron
  Chairman of the Board and Director
  July 15, 2005
  Joel-Tomas Citron
  /s/ Frederick W. Driscoll
  President, Chief Executive
  Officer and Director
  July 15, 2005
  Frederick W. Driscoll
  (Principal executive officer)
  /s/ James B. Murphy
  Chief Financial Officer
  July 15, 2005
  James B. Murphy
  (Principal financial officer and principal accounting officer)
  /s/ Arthur B. Laffer
  Director
  July 15, 2005
  Arthur B. Laffer
  /s/ William N. Shiebler
  Director
  July 15, 2005
  William N. Shiebler
  5
  Table of Contents
  Signature
  Title
  Date
  /s/ Per-Olof Söderberg
  Director
  July 15, 2005
  Per-Olof Söderberg
  /s/ J. Richard Zecher
  Director
  July 15, 2005
  J. Richard Zecher
  6
  Table of Contents
  OXiGENE, Inc.
  INDEX TO EXHIBITS FILED WITH
  FORM S-8 REGISTRATION STATEMENT
  Exhibit
  Number
  Description
  (4.1)
  Form of Common Stock Certificate (Filed as Exhibit to the
  Registrant's Registration Statement on Form S-1, as amended, No.
  033-64968, and incorporated herein by reference).
  (4.2)
  Restated Certificate of Incorporation of the Registrant (Filed as
  Exhibit to the Registrant's Registration Statement on Form S-1, as
  amended, No. 033-64968, and incorporated herein by reference).
  (4.3)
  Certificate of Amendment of Restated Certificate of Incorporation of
  the Registrant (Filed as Exhibit to the Registrant's Annual Report
  of Form 10-K for the fiscal year ended December 31, 1996, No.
  000-21990, and incorporated herein by reference).
  (4.4)
  Certificate of Amendment of Restated Certificate of Incorporation of
  the Registrant.
  (4.5)
  Amended and Restated By-Laws of the Registrant (Filed as Exhibit to
  the Registrant's Quarterly Report on Form 10-Q for the quarter ended
  March 31, 2004, No. 000-21990, and incorporated herein by
  reference).
  (4.6)
  Stockholder Rights Agreement (Filed as Exhibit to the Registrant's
  Registration Statement on Form 8-A12G, File No. 000-21990, and
  incorporated herein by reference).
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to
  the legality of shares being registered.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  (included in opinion of counsel filed as Exhibit 5).
  (23.2)
  Consent of Ernst & Young LLP.
  (24)
  Power of Attorney to file future amendments (set forth on the
  signature page of this Registration Statement).
  (99.1)
  OXiGENE, Inc. 2005 Stock Plan (Filed as Exhibit to the Registrant's
  Current Report on Form 8-K, File No. 000-21990, and incorporated
  herein by reference).
  7