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  <TITLE>FORM S-8 ALKERMES,INC.</TITLE>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  <P align="right"><FONT size="2">Registration No.&nbsp;333-
  </FONT>
  
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  <P align="center"><FONT size="4"><B>SECURITIES AND EXCHANGE COMMISSION
  </B></FONT>
  
  
  <DIV align="center"><FONT size="3"><B>Washington, D.C. 20549</B>
  </FONT></DIV>
  
  
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  <P align="center"><FONT size="5"><B>FORM S-8
  </B></FONT>
  
  
  <P align="center"><FONT size="2"><B>REGISTRATION STATEMENT<BR>
  UNDER THE SECURITIES ACT OF 1933</B>
  </FONT>
  
  
  <P align="center"><HR align="center" size="1" width="15%" noshade>
  
  
  <P align="center"><FONT size="2"><B>ALKERMES, INC.</B><BR>
  (Exact name of registrant as specified in its charter)
  </FONT>
  
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      <TD align="center" valign="top"><FONT size="2">Pennsylvania</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center" valign="top"><FONT size="2">
  23-2472830</FONT></TD>
  </TR>
  
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      <TD align="center" valign="top"><FONT size="2">(State or other jurisdiction of</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center" valign="top"><FONT size="2">
  (I.R.S. Employer</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><FONT size="2">incorporation or organization)</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center" valign="top"><FONT size="2">
  Identification Number)</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  
  <P align="center"><FONT size="2"><B>ALKERMES, INC.<BR>
  88 SIDNEY STREET<BR>
  CAMBRIDGE, MASSACHUSETTS 02139-4234<BR>
  TELEPHONE: (617)&nbsp;494-0171</B><BR>
  (Address, including zip code, and telephone number, including area code,<BR>
  of registrant&#146;s principal executive offices)
  </FONT>
  
  
  <P align="center"><FONT size="2"><B>ALKERMES, INC. 1999 STOCK OPTION PLAN</B><BR>
  (Full title of the plan)
  </FONT>
  
  
  <P align="center"><FONT size="2">Richard F. Pops<BR>
  Chief Executive Officer<BR>
  ALKERMES, INC.<BR>
  88 Sidney Street<BR>
  Cambridge, Massachusetts 02139-4234<BR>
  Telephone: (617)&nbsp;494-0171<BR>
  (Name, address, including zip code, and telephone number, including area code,<BR>
  of agent for service)
  </FONT>
  
  
  <P align="center"><HR align="center" size="1" width="15%" noshade>
  
  
  <P align="center"><FONT size="2">Copies to:<BR>
  Jennifer L. Miller, Esquire<BR>
  Ballard Spahr Andrews &#038; Ingersoll, LLP<BR>
  1735 Market Street, 51st Floor<BR>
  Philadelphia, Pennsylvania 19103<BR>
  Telephone: (215)&nbsp;864-8619
  </FONT>
  
  
  <P align="center"><HR align="center" size="1" width="15%" noshade>
  
  
  <P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B>
  </FONT>
  
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      <TD width="3%">&nbsp;</TD>
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      <TD width="1%">&nbsp;</TD>
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      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD nowrap align="center"><FONT size="1"><B>Title of Securities</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount to be</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price Per</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate Offering</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>to be Registered</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered(1)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Share(2)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price(2)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration Fee</B></FONT></TD>
  </TR>
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      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock,
  Par value $.01 per
  share</FONT></DIV></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">1,500,000</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">12.58</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">18,870,000</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">1,526.58</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
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  <P align="center"><FONT size="2">&nbsp;</FONT>
  
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <P>
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416(a) under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend and the like.</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
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      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="96%"><FONT size="2">Estimated solely for the purpose of calculating the registration fee. In
  accordance with Rule&nbsp;457(h), the price shown is based upon the average of
  the high and low price of the Company&#146;s Common Stock on July&nbsp;16, 2003,
  $12.58, as reported on the Nasdaq National Market for securities of the
  same class as those to be offered.</FONT></TD>
  </TR>
  </TABLE>
  <P align="center"><FONT size="2">&nbsp;</FONT>
  
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  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
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  </TR>
  <TR><TD colspan="9"><A HREF="#000"> PART II &#151; INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Certain Documents by Reference.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;8. Exhibits.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#004"> SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#005"> EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47244a1exv5.txt">EX-5 OPINION OF BALLARD SPAHR ANDREWS & INGERSOLL</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47244a1exv23w2.txt">EX-23.2 CONSENT OF DELOITTE & TOUCHE LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47244a1exv23w3.txt">EX-23.3 CONSENT OF ERNST & YOUNG LLP</A></TD></TR>
  </TABLE>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Part I and Items 4, 6, 7 and 9 of Part II of Alkermes, Inc.&#146;s Registration
  Statement on Form&nbsp;S-8 (File No.&nbsp;333-89573) are incorporated by reference herein
  pursuant to Instruction E of Form&nbsp;S-8.
  </FONT>
  
  <!-- link1 " PART II &#151; INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="center"><FONT size="2">PART II &#151; INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  </FONT>
  
  <!-- link2 "Item&nbsp;3. Incorporation of Certain Documents by Reference." -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;3. Incorporation of Certain Documents by Reference.</B>
  </FONT>
  
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed with the Securities and Exchange Commission
  (the &#147;Commission&#148;) pursuant to the Securities Exchange Act of 1934 (the
  &#147;Exchange Act&#148;) by Alkermes, Inc. (the &#147;Company&#148;) (File No.&nbsp;1-14131) or
  pursuant to the Securities Act of 1933, as amended (the &#147;Securities Act&#148;) are
  incorporated herein by reference:
  </FONT>
  
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      <TD width="5%">&nbsp;</TD>
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      <TD width="85%">&nbsp;</TD>
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      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  (a)
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Annual Report on Form&nbsp;10-K for the fiscal year
  ended March&nbsp;31, 2003;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
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      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  (b)
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Item&nbsp;1 of Registration Statement of the Company
  on Form&nbsp;8-A dated June&nbsp;28, 1991, as amended by a Registration Statement of the Company on
  Form&nbsp;8-A/A dated January&nbsp;17, 1997; and</FONT></TD>
  </TR>
  
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      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
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      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  (c)
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Item&nbsp;1 of Registration Statement of the Company
  on Form&nbsp;8-A dated May&nbsp;2, 2003.</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14
  or 15(d) of the Exchange Act, after the date of this Registration Statement and
  prior to the termination of the offering, shall be deemed to be incorporated by
  reference herein and to be part hereof from the date of filing such documents.
  Any statement contained herein or in a document incorporated by reference or
  deemed to be incorporated by reference herein shall be deemed to be modified or
  superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document
  which is incorporated or is deemed to be incorporated by reference herein. Any
  such statement so modified or superseded shall not be deemed, except as so
  modified or superseded, to constitute a part of this Registration Statement.
  </FONT>
  
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  </FONT>
  
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Morris Cheston, Jr., Esquire, Secretary of the Company and Jennifer L.
  Miller, Esquire, Secretary of Alkermes Investments, Inc., a wholly-owned
  subsidiary of Alkermes, Inc., are both partners in the law firm of Ballard
  Spahr Andrews &#038; Ingersoll, LLP which has given an opinion passing upon the
  validity of the securities being registered hereby.
  </FONT>
  
  <!-- link2 "Item&nbsp;8. Exhibits." -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits.</B>
  </FONT>
  
  <CENTER>
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      <TD width="2%">&nbsp;</TD>
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      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="91%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  4.1</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Specimen of Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1 as amended (File No.&nbsp;33-40250)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  4.2</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Specimen of Non-Voting Common Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit&nbsp;4.4 to the Registrant&#146;s
  Report on Form&nbsp;10-K for the fiscal year ended March&nbsp;31, 1999).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  4.3</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Specimen of 2002 Preferred Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s
  Current Report on Form&nbsp;8-K filed on December&nbsp;13, 2002).</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">II-1</FONT>
  
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  <CENTER>
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  <TR valign="bottom">
      <TD width="2%">&nbsp;</TD>
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      <TD width="3%">&nbsp;</TD>
      <TD width="91%">&nbsp;</TD>
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      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  4.4</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Indenture, dated as of February&nbsp;18, 2000, between Alkermes,
  Inc. and State Street Bank and Trust Company, as Trustee (3.75%
  Subordinated Notes). (Incorporated by reference to Exhibit&nbsp;4.6 to
  the Registrant&#146;s Registration Statement on Form&nbsp;S-3, as amended
  (File No.&nbsp;333-31354)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  4.5</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Form of Indenture between Alkermes, Inc. and State Street
  Bank and Trust Company, as Trustee (6.52% Senior Notes).
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.
  333-101464)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  4.6</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Rights Agreement, dated February&nbsp;7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Registration Statement
  on Form&nbsp;8-A filed on May&nbsp;2, 2003).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  5</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Opinion of Ballard Spahr Andrews &#038; Ingersoll, LLP as to the
  legality of the securities to be offered.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  23.1</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Consent of Ballard Spahr Andrews &#038; Ingersoll, LLP (included as part of Exhibit&nbsp;5).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  23.2</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Independent Auditors&#146; Consent of Deloitte &#038; Touche LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  23.3</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Consent of Independent Auditors of Ernst &#038; Young LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  24</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Power of Attorney (included in signature page).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right" valign="top"><FONT size="2">
  99</FONT></TD>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Alkermes, Inc. 1999 Stock Option Plan, as amended
  (Incorporated by reference to Exhibit&nbsp;10.1 to the Registrant&#146;s
  Quarterly Report on Form&nbsp;10-Q for the quarter ended September&nbsp;30,
  2002).</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">II-2</FONT>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <!-- link1 " SIGNATURES" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <P align="center"><FONT size="2">SIGNATURES
  </FONT>
  
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form&nbsp;S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of Cambridge, Commonwealth of Massachusetts, on July
  21, 2003.
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="55%">
  <TR valign="bottom">
      <TD width="21%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="66%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD colspan="3" valign="top" align="left"><FONT size="2">ALKERMES, INC.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  By
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">/s/ Richard F. Pops</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Richard F. Pops<br>
  Chief Executive Officer</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed below by the following persons in the
  capacities and on the dates indicated.
  </FONT>
  
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below in so signing also makes,
  constitutes and appoints Richard F. Pops and James M. Frates, and each of them,
  his true and lawful attorney-in-fact, with full power of substitution, for him
  in any and all capacities, to execute and cause to be filed with the Securities
  and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in
  connection therewith, and hereby ratifies and confirms all that said
  attorney-in-fact or his substitute or substitutes may do or cause to be done by
  virtue hereof.
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="31%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="44%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director and
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"></FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">Michael A. Wall</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Chairman of the</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Board</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Richard F. Pops</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director and Chief
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Executive Officer</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">Richard F. Pops</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  (Principal</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Executive Officer)</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Robert A. Breyer</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">Robert A. Breyer</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ James M. Frates</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Vice President, Chief
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Financial Officer and</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">James M. Frates</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Treasurer</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  (Principal Financial Officer</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  and Principal Accounting</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Officer)</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">II-3</FONT>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
      <TD width="31%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="44%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Floyd E. Bloom</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">Floyd E. Bloom</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ John K. Clarke</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">John K. Clarke</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Alexander Rich</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">Alexander Rich</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Paul Schimmel</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">Paul Schimmel</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Gerri Henwood</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  
  <TD align="left" valign="top"><FONT size="2">July 21, 2003</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">Gerri Henwood</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Paul J. Mitchell</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July 21, 2003</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><HR size="1" noshade></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">Paul J. Mitchell</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">II-4</FONT>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <!-- link1 " EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <P align="center"><FONT size="2"><B>EXHIBIT INDEX</B>
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Number</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Exhibit</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by
  reference to Exhibit&nbsp;4 to the Registrant&#146;s Registration Statement on Form
  S-1 as amended (File No.&nbsp;33-40250)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Non-Voting Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4.4 to the Registrant&#146;s Report on
  Form 10-K for the fiscal year ended March&nbsp;31, 1999).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Current
  Report on Form&nbsp;8-K filed on December&nbsp;13, 2002).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.4</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Indenture, dated as of February&nbsp;18, 2000, between Alkermes, Inc. and
  State Street Bank and Trust Company, as Trustee (3.75% Subordinated
  Notes). (Incorporated by reference to Exhibit&nbsp;4.6 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-3, as amended (File No.&nbsp;333-31354)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Form of Indenture between Alkermes, Inc. and State Street Bank and Trust
  Company, as Trustee (6.52% Senior Notes). (Incorporated by reference to
  Exhibit&nbsp;4.1 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as
  amended (File No.&nbsp;333-101464)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.6</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Rights Agreement, dated February&nbsp;7, 2003, as amended, between Alkermes,
  Inc. and EquiServe Trust Co., N.A., as Rights Agent. (Incorporated by
  reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Registration Statement on Form&nbsp;8-A filed on
  May&nbsp;2, 2003).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Opinion of Ballard Spahr Andrews &#038; Ingersoll, LLP as to the legality of
  the securities to be offered.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Ballard Spahr Andrews &#038; Ingersoll, LLP (included as part of Exhibit&nbsp;5).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Independent Auditors&#146; Consent of Deloitte &#038; Touche LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Independent Auditors of Ernst &#038; Young LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">24</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Power of Attorney (included in signature page).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">99</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Alkermes, Inc. 1999 Stock Option Plan, as amended (Incorporated by
  reference to Exhibit&nbsp;10.1 to the Registrant&#146;s Quarterly Report on Form
  10-Q for the quarter ended September&nbsp;30, 2002).</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  
  
  <P align="center"><FONT size="2">&nbsp;</FONT>
  
  
  
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "b47244a1sv8.htm", "description": "FORM S-8 ALKERMES,INC.", "secsgml_size_bytes": 54082}]
metadata_filer: {"company-data": {"conformed-name": "ALKERMES INC", "cik": "0000874663", "assigned-sic": "2834", "irs-number": "232472830", "state-of-incorporation": "PA", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-107206", "film-number": "03794888"}, "business-address": {"street1": "88 SIDNEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02139-4136", "phone": "617-494-0171"}}
text: FORM S-8 ALKERMES,INC.
  Table of Contents
  Registration No. 333-
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER THE SECURITIES ACT OF 1933
  ALKERMES, INC.
  (Exact name of registrant as specified in its charter)
  Pennsylvania
  23-2472830
  (State or other jurisdiction of
  (I.R.S. Employer
  incorporation or organization)
  Identification Number)
  ALKERMES, INC.
  88 SIDNEY STREET
  CAMBRIDGE, MASSACHUSETTS 02139-4234
  TELEPHONE: (617) 494-0171
  (Address, including zip code, and telephone number, including area code,
  of registrant's principal executive offices)
  ALKERMES, INC. 1999 STOCK OPTION PLAN
  (Full title of the plan)
  Richard F. Pops
  Chief Executive Officer
  ALKERMES, INC.
  88 Sidney Street
  Cambridge, Massachusetts 02139-4234
  Telephone: (617) 494-0171
  (Name, address, including zip code, and telephone number, including area code,
  of agent for service)
  Copies to:
  Jennifer L. Miller, Esquire
  Ballard Spahr Andrews & Ingersoll, LLP
  1735 Market Street, 51st Floor
  Philadelphia, Pennsylvania 19103
  Telephone: (215) 864-8619
  CALCULATION OF REGISTRATION FEE
  Proposed Maximum
  Proposed Maximum
  Title of Securities
  Amount to be
  Offering Price Per
  Aggregate Offering
  Amount of
  to be Registered
  Registered(1)
  Share(2)
  Price(2)
  Registration Fee
  Common Stock,
  Par value $.01 per
  share
  1,500,000
  $
  12.58
  $
  18,870,000
  $
  1,526.58
  Table of Contents
  (1)
  Pursuant to Rule 416(a) under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend and the like.
  (2)
  Estimated solely for the purpose of calculating the registration fee. In
  accordance with Rule 457(h), the price shown is based upon the average of
  the high and low price of the Company's Common Stock on July 16, 2003,
  $12.58, as reported on the Nasdaq National Market for securities of the
  same class as those to be offered.
  TABLE OF CONTENTS
  PART II — INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference.
  Item 5. Interests of Named Experts and Counsel.
  Item 8. Exhibits.
  SIGNATURES
  EXHIBIT INDEX
  EX-5 OPINION OF BALLARD SPAHR ANDREWS & INGERSOLL
  EX-23.2 CONSENT OF DELOITTE & TOUCHE LLP
  EX-23.3 CONSENT OF ERNST & YOUNG LLP
  Table of Contents
  Part I and Items 4, 6, 7 and 9 of Part II of Alkermes, Inc.'s Registration
  Statement on Form S-8 (File No. 333-89573) are incorporated by reference herein
  pursuant to Instruction E of Form S-8.
  PART II — INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference.
  The following documents filed with the Securities and Exchange Commission
  (the "Commission") pursuant to the Securities Exchange Act of 1934 (the
  "Exchange Act") by Alkermes, Inc. (the "Company") (File No. 1-14131) or
  pursuant to the Securities Act of 1933, as amended (the "Securities Act") are
  incorporated herein by reference:
  (a)
  Annual Report on Form 10-K for the fiscal year
  ended March 31, 2003;
  (b)
  Item 1 of Registration Statement of the Company
  on Form 8-A dated June 28, 1991, as amended by a Registration Statement of the Company on
  Form 8-A/A dated January 17, 1997; and
  (c)
  Item 1 of Registration Statement of the Company
  on Form 8-A dated May 2, 2003.
  All documents filed by the Company pursuant to Sections 13(a), 13(c), 14
  or 15(d) of the Exchange Act, after the date of this Registration Statement and
  prior to the termination of the offering, shall be deemed to be incorporated by
  reference herein and to be part hereof from the date of filing such documents.
  Any statement contained herein or in a document incorporated by reference or
  deemed to be incorporated by reference herein shall be deemed to be modified or
  superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document
  which is incorporated or is deemed to be incorporated by reference herein. Any
  such statement so modified or superseded shall not be deemed, except as so
  modified or superseded, to constitute a part of this Registration Statement.
  Item 5. Interests of Named Experts and Counsel.
  Morris Cheston, Jr., Esquire, Secretary of the Company and Jennifer L.
  Miller, Esquire, Secretary of Alkermes Investments, Inc., a wholly-owned
  subsidiary of Alkermes, Inc., are both partners in the law firm of Ballard
  Spahr Andrews & Ingersoll, LLP which has given an opinion passing upon the
  validity of the securities being registered hereby.
  Item 8. Exhibits.
  4.1
  Specimen of Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4 to the Registrant's
  Registration Statement on Form S-1 as amended (File No. 33-40250)).
  4.2
  Specimen of Non-Voting Common Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit 4.4 to the Registrant's
  Report on Form 10-K for the fiscal year ended March 31, 1999).
  4.3
  Specimen of 2002 Preferred Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit 4.1 to the Registrant's
  Current Report on Form 8-K filed on December 13, 2002).
  II-1
  Table of Contents
  4.4
  Indenture, dated as of February 18, 2000, between Alkermes,
  Inc. and State Street Bank and Trust Company, as Trustee (3.75%
  Subordinated Notes). (Incorporated by reference to Exhibit 4.6 to
  the Registrant's Registration Statement on Form S-3, as amended
  (File No. 333-31354)).
  4.5
  Form of Indenture between Alkermes, Inc. and State Street
  Bank and Trust Company, as Trustee (6.52% Senior Notes).
  (Incorporated by reference to Exhibit 4.1 to the Registrant's
  Registration Statement on Form S-1, as amended (File No.
  333-101464)).
  4.6
  Rights Agreement, dated February 7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement
  on Form 8-A filed on May 2, 2003).
  5
  Opinion of Ballard Spahr Andrews & Ingersoll, LLP as to the
  legality of the securities to be offered.
  23.1
  Consent of Ballard Spahr Andrews & Ingersoll, LLP (included as part of Exhibit 5).
  23.2
  Independent Auditors' Consent of Deloitte & Touche LLP.
  23.3
  Consent of Independent Auditors of Ernst & Young LLP.
  24
  Power of Attorney (included in signature page).
  99
  Alkermes, Inc. 1999 Stock Option Plan, as amended
  (Incorporated by reference to Exhibit 10.1 to the Registrant's
  Quarterly Report on Form 10-Q for the quarter ended September 30,
  2002).
  II-2
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of Cambridge, Commonwealth of Massachusetts, on July
  21, 2003.
  ALKERMES, INC.
  By
  /s/ Richard F. Pops
  Richard F. Pops
  Chief Executive Officer
  Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed below by the following persons in the
  capacities and on the dates indicated.
  Each person whose signature appears below in so signing also makes,
  constitutes and appoints Richard F. Pops and James M. Frates, and each of them,
  his true and lawful attorney-in-fact, with full power of substitution, for him
  in any and all capacities, to execute and cause to be filed with the Securities
  and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in
  connection therewith, and hereby ratifies and confirms all that said
  attorney-in-fact or his substitute or substitutes may do or cause to be done by
  virtue hereof.
  Signature
  Title
  Date
  Director and
  Michael A. Wall
  Chairman of the
  Board
  /s/ Richard F. Pops
  Director and Chief
  July 21, 2003
  Executive Officer
  Richard F. Pops
  (Principal
  Executive Officer)
  /s/ Robert A. Breyer
  Director
  July 21, 2003
  Robert A. Breyer
  /s/ James M. Frates
  Vice President, Chief
  July 21, 2003
  Financial Officer and
  James M. Frates
  Treasurer
  (Principal Financial Officer
  and Principal Accounting
  Officer)
  II-3
  Table of Contents
  Signature
  Title
  Date
  /s/ Floyd E. Bloom
  Director
  July 21, 2003
  Floyd E. Bloom
  /s/ John K. Clarke
  Director
  July 21, 2003
  John K. Clarke
  /s/ Alexander Rich
  Director
  July 21, 2003
  Alexander Rich
  /s/ Paul Schimmel
  Director
  July 21, 2003
  Paul Schimmel
  /s/ Gerri Henwood
  Director
  July 21, 2003
  Gerri Henwood
  /s/ Paul J. Mitchell
  Director
  July 21, 2003
  Paul J. Mitchell
  II-4
  Table of Contents
  EXHIBIT INDEX
  Number
  Exhibit
  4.1
  Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by
  reference to Exhibit 4 to the Registrant's Registration Statement on Form
  S-1 as amended (File No. 33-40250)).
  4.2
  Specimen of Non-Voting Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4.4 to the Registrant's Report on
  Form 10-K for the fiscal year ended March 31, 1999).
  4.3
  Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's Current
  Report on Form 8-K filed on December 13, 2002).
  4.4
  Indenture, dated as of February 18, 2000, between Alkermes, Inc. and
  State Street Bank and Trust Company, as Trustee (3.75% Subordinated
  Notes). (Incorporated by reference to Exhibit 4.6 to the Registrant's
  Registration Statement on Form S-3, as amended (File No. 333-31354)).
  4.5
  Form of Indenture between Alkermes, Inc. and State Street Bank and Trust
  Company, as Trustee (6.52% Senior Notes). (Incorporated by reference to
  Exhibit 4.1 to the Registrant's Registration Statement on Form S-1, as
  amended (File No. 333-101464)).
  4.6
  Rights Agreement, dated February 7, 2003, as amended, between Alkermes,
  Inc. and EquiServe Trust Co., N.A., as Rights Agent. (Incorporated by
  reference to Exhibit 4.1 to the Registrant's Registration Statement on Form 8-A filed on
  May 2, 2003).
  5
  Opinion of Ballard Spahr Andrews & Ingersoll, LLP as to the legality of
  the securities to be offered.
  23.1
  Consent of Ballard Spahr Andrews & Ingersoll, LLP (included as part of Exhibit 5).
  23.2
  Independent Auditors' Consent of Deloitte & Touche LLP.
  23.3
  Consent of Independent Auditors of Ernst & Young LLP.
  24
  Power of Attorney (included in signature page).
  99
  Alkermes, Inc. 1999 Stock Option Plan, as amended (Incorporated by
  reference to Exhibit 10.1 to the Registrant's Quarterly Report on Form
  10-Q for the quarter ended September 30, 2002).