content: <HTML>
  <HEAD>
  <TITLE>sv8</TITLE>
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">As filed with the Securities and Exchange Commission on February&nbsp;9, 2009<BR>
  Registration No.&nbsp;333-<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT UNDER<BR>
  THE SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>ALKERMES, INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact Name of Company as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="48%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="48%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Pennsylvania</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>23-2472830</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or other jurisdiction of incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>ALKERMES, INC.<BR>
  88 SIDNEY STREET<BR>
  CAMBRIDGE, MASSACHUSETTS 02139-4234</B><BR>
  (Address, including zip code, of registrant&#146;s principal executive offices)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>ALKERMES, INC. 2008 STOCK OPTION AND INCENTIVE PLAN</B><BR>
  (Full title of the plan)<BR>
  David A. Broecker<BR>
  Chief Executive Officer<BR>
  ALKERMES, INC.<BR>
  88 Sidney Street<BR>
  Cambridge, Massachusetts 02139-4234<BR>
  Telephone: (617)&nbsp;494-0171<BR>
  (Name, address, including zip code, and telephone number, including area code,<BR>
  of agent for service)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">Copies to:</DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top">Mitchell S. Bloom, Esq.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Kathryn L. Biberstein, Esq.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Robert E. Puopolo, Esq.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Alkermes, Inc.</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Goodwin Procter LLP
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">88 Sidney Street</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">53 State Street
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Cambridge, MA 02139</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Boston, MA 02109
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Telephone: (617)&nbsp;583-6255</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Telephone: (617)&nbsp;570-1000</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer,
  or a non-accelerated filer. See definition of &#147;accelerated filer and large accelerated filer&#148; in
  Rule&nbsp;12b-2 of the Exchange Act.
  </DIV>
  
  
  
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="22%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="left" valign="top">Large accelerated filer <FONT face="Wingdings">&#254;</FONT>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Accelerated filer <FONT face="Wingdings">&#111;</FONT>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Non-accelerated filer <FONT face="Wingdings">&#111;</FONT>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" nowrap>Smaller reporting company <FONT face="Wingdings">&#111;</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" nowrap>(Do not check if a smaller reporting company)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>CALCULATION OF REGISTRATION FEE</B></DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
  
  <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%" style="border-left: 0px solid #000000">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%" style="border-right: 0px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%" style="border-left: 0px solid #000000">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Maximum</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Maximum</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%" style="border-right: 0px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%" style="border-left: 0px solid #000000">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Offering</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Aggregate</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%" style="border-right: 0px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%" style="border-left: 0px solid #000000">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>to be</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Price Per</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Offering</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
      <TD width="1%" style="border-right: 0px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%" style="border-left: 0px solid #000000">&nbsp;</TD>
  
      <TD nowrap align="center"><B>Title of Securities to be registered</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Registered (2) (5)</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Share</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Price</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Registration Fee</B></TD>
      <TD width="1%" style="border-right: 0px solid #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-left: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value $0.01 per share(1)</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">258,000</TD>
      <TD nowrap style="border-top: 1px solid #000000">(3)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">11.44</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">2,951,520</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-right: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-left: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value $0.01 per share(1)</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">109,000</TD>
      <TD nowrap style="border-top: 1px solid #000000">(3)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">10.10</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">1,100,900</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-right: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-left: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value $0.01 per share(1)</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">7,000</TD>
      <TD nowrap style="border-top: 1px solid #000000">(3)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">10.71</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">74,970</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-right: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-left: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value $0.01 per share(1)</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">313,000</TD>
      <TD nowrap style="border-top: 1px solid #000000">(3)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">11.98</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">3,749,740</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-right: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-left: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value $0.01 per share(1)</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">25,760,858</TD>
      <TD nowrap style="border-top: 1px solid #000000">(4)</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">11.04</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">284,399,873</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-right: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-left: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:30px; text-indent:-15px"><B>Total:</B></DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">26,447,858</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">292,277,003</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">11,487</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-right: 0px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 3pt; width: 18%; border-top: 0px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>This Registration Statement also relates to the Rights to purchase
  shares of Series&nbsp;A Junior Participating Preferred Stock of the
  Registrant which are attached to all shares of Common Stock pursuant
  to the terms of the Registrant&#146;s Rights Agreement dated February&nbsp;7,
  2003. Until the occurrence of certain prescribed events, the Rights
  are not exercisable, are evidenced by the certificates for the Common
  Stock and will be transferred only with such stock.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Pursuant to Rule 416(c) under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend, recapitalization, and certain other
  capital adjustments and the like.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>Such shares are issuable upon the exercise of outstanding options with
  fixed exercise prices. Pursuant to Rule&nbsp;457(h), the aggregate offering
  price and fee have been computed upon the basis of the price at which
  such options may be exercised. The offering price per share set forth
  for such shares is the exercise price per share at which such options
  are exercisable.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(4)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of calculating the registration fee.
  In accordance with Rules 457(c) and 457(h), the proposed maximum
  offering price per share, the proposed maximum aggregate offering
  price, and the registration fee shown has been computed based upon the
  average of the high and low sales price of the Company&#146;s Common Stock
  on February&nbsp;6, 2009, $11.04, as reported on the Nasdaq Global Market
  with respect to securities for which options have not been granted.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(5)</TD>
      <TD>&nbsp;</TD>
      <TD>The maximum number of shares of Common Stock reserved and available
  for issuance under the Plan includes: (i)&nbsp;6,400,000 shares, plus
  (ii)&nbsp;up to 3,070,779 shares of Common Stock which were previously
  available for grant under the Alkermes, Inc. 1999 Stock Option Plan,
  the Alkermes, Inc. 2002 Restricted Stock Award Plan and the Alkermes,
  Inc. 2006 Stock Option Plan For Non-Employee Directors (together, the
  &#147;Old Stock Plans&#148;) and now available for grant under the Plan, plus
  (iii)&nbsp;up to 16,977,079 shares of Common Stock underlying outstanding
  grants pursuant to the Old Stock Plans that may be available for grant
  under the Plan if they are forfeited, cancelled, repurchased or are
  terminated (other than by exercise).</TD>
  </TR>
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B></DIV>
  
  <!--TOC-->
  <!--/TOC-->
  
  <!-- link2 "Item&nbsp;1.Plan Information" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;1. <U>Plan Information</U>.</DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The documents containing the information specified in this Part&nbsp;I will be sent or given to
  employees, directors or others as specified by Rule&nbsp;428(b)(1). In accordance with the rules and
  regulations of the Securities and Exchange Commission (the &#147;Commission&#148;) and the Introductory Note
  to Part&nbsp;I of Form S-8, such documents are not being filed with the Commission either as part of
  this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule&nbsp;424.</DIV>
  
  <!-- link2 "Item&nbsp;2.Registrant Information and Employee Plan Annual Information" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;2. <U>Registrant Information and Employee Plan Annual Information</U>.</DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The documents containing the information specified in this Part&nbsp;I will be sent or given to
  employees, directors or others as specified by Rule&nbsp;428(b)(1). In accordance with the rules and
  regulations of the Commission and the Introductory Note to Part&nbsp;I of Form S-8, such documents are
  not being filed with the Commission either as part of this Registration Statement or as
  prospectuses or prospectus supplements pursuant to Rule&nbsp;424.</DIV>
  <!-- link1 "PART II" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B></DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  </DIV>
  <!-- link2 "Item&nbsp;3.Incorporation of Documents by Reference" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;3. <U>Incorporation of Documents by Reference</U>.</DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed with the Commission are incorporated by reference in this
  Registration Statement:</DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended March&nbsp;31, 2008 filed with the Commission on May&nbsp;30,
  2008;<br><BR style="font-size:6pt">
  The Registrant&#146;s Quarterly Report on Form 10-Q for the three months ended June&nbsp;30, 2008 filed with the Commission on
  August&nbsp;7, 2008;<br><BR style="font-size:6pt">
  The Registrant&#146;s Quarterly Report on Form 10-Q for the three months ended September&nbsp;30, 2008 filed with the Commission on
  November&nbsp;7, 2008;<br><BR style="font-size:6pt">
  The Registrant&#146;s Quarterly Report on Form 10-Q for the three months ended December&nbsp;31, 2008 filed with the Commission on
  February&nbsp;9, 2009;<br><BR style="font-size:6pt">
  The Registrant&#146;s Current Reports on Forms 8-K filed with the Commission on May&nbsp;16, 2008; May&nbsp;28, 2008; June&nbsp;16, 2008 (<I>Item
  8.01 only</I>); October&nbsp;7, 2008; November&nbsp;4, 2008; and December&nbsp;1, 2008 (<I>Item&nbsp;1.02 only</I>).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>All other reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the &#147;Exchange
  Act &#147;), since March&nbsp;31, 2008; and</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Item&nbsp;1 of Registration Statement of the Company on Form 8-A dated June&nbsp;28, 1991, as amended by a Registration Statement of
  the Company on Form 8-A/A dated January&nbsp;17, 1997; and Item&nbsp;1 of Registration Statement of the Company on Form 8-A dated
  May&nbsp;2, 2003.</TD>
  </TR>
  
  </TABLE></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14 or 15(d) of the Exchange
  Act, after the date of this Registration Statement and prior to the filing of a post-effective
  amendment which indicates that all securities offered herein have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing such documents. Any statement contained herein or in a
  document incorporated by reference or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document which is incorporated
  or is deemed to be incorporated by reference herein. Any such statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this Registration
  Statement.</DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio --></DIV>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link2 "Item&nbsp;4. Description of Securities" -->
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;4. <U>Description of Securities</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel" -->
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;5. <U>Interests of Named Experts and Counsel</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  
  
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers" -->
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;6. <U>Indemnification of Directors and Officers</U>.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">The Pennsylvania Business Corporation Law of 1988, as amended, authorizes the Company to grant
  indemnification to directors and officers in terms sufficiently broad to permit such
  indemnification under certain circumstances for liabilities (including reimbursement for expenses
  incurred) arising under the Securities Act of 1933, as amended. The Company has also obtained
  Directors&#146; and Officers&#146; Liability Insurance which insures its officers and directors against
  certain liabilities such persons may incur in their capacities as officers or directors of the
  Company. In addition, the Company&#146;s By-laws contain the following provisions:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#147;5.1 INDEMNIFICATION OF DIRECTORS, OFFICERS, AND OTHER PERSONS. The Corporation shall
  indemnify any director, officer, employee or agent of the Corporation or any of its subsidiaries
  who was or is an &#147;authorized representative&#148; of the Corporation (which shall mean, for the purpose
  of this Article, a director or officer of the Corporation, or a person serving at the request of
  the Corporation as a director, officer, partner, fiduciary or trustee of another corporation,
  partnership, joint venture, trust, employee benefit plan or other enterprise) and who was or is a
  &#147;party&#148; (which shall include for purposes of this Article the giving of testimony or similar
  involvement) or is threatened to be made a party to any &#147;proceeding&#148; (which shall mean for purposes
  of this Article any threatened, pending or completed action, suit, appeal or other proceeding of
  any nature, whether civil, criminal, administrative or investigative, whether formal or informal,
  and whether brought by or in the right of the Corporation, its shareholders or otherwise) by reason
  of the fact that such person was or is an authorized representative of the Corporation to the
  fullest extent permitted by law, including without limitation indemnification against expenses
  (which shall include for purposes of this Article attorneys&#146; fees and disbursements), damages,
  punitive damages, judgments, penalties, fines and amounts paid in settlement actually and
  reasonably incurred by such person in connection with such proceeding unless the act or failure to
  act giving rise to the claim is finally determined by a court to have constituted willful
  misconduct or recklessness. If an authorized representative is not entitled to indemnification in
  respect of a portion of any liabilities to which such person may be subject, the Corporation shall
  nonetheless indemnify such person to the maximum extent for the remaining portion of the
  liabilities.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#147;5.2 ADVANCEMENT OF EXPENSES. The Corporation shall pay the expenses (including
  attorneys&#146; fees and disbursements) actually and reasonably incurred in defending a proceeding on
  behalf of any person entitled to indemnification under Section&nbsp;5.1 in advance of the final
  disposition of such proceeding upon receipt of an undertaking by or on behalf of such person to
  repay such amount if it shall ultimately be determined that such person is not entitled to be
  indemnified by the Corporation as authorized in this Article and may pay such expenses in advance
  on behalf of any employee or agent on receipt of a similar undertaking. The financial ability of
  such authorized representative to make such repayment shall not be prerequisite to the making of an
  advance.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#147;5.3 EMPLOYEE BENEFIT PLANS. For purposes of this Article, the Corporation shall be
  deemed to have requested an officer, director, employee or agent to serve as fiduciary with respect
  to an employee benefit plan where the performance by such person of duties to the Corporation also
  imposes duties on, or otherwise involves services by, such person as a fiduciary with respect to
  the plan; excise taxes assessed on an authorized representative with respect to any transaction
  with an employee benefit plan shall be deemed &#147;fines&#148;; and action taken or omitted by such person
  with respect to an employee benefit plan in the performance of duties for a purpose reasonably
  believed to be in the interest of the participants and beneficiaries of the plan shall be deemed to
  be for a purpose which is not opposed to the best interests of the Corporation.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#147;5.4 SECURITY FOR INDEMNIFICATION OBLIGATIONS. To further effect, satisfy or secure the
  indemnification obligations provided herein or otherwise, the Corporation may maintain insurance,
  obtain a letter of credit, act as self-insurer, create a reserve, trust, escrow, cash collateral or
  other fund or account, enter into indemnification agreements, pledge or grant a security interest
  in any assets or properties of the Corporation, or use any other mechanism or arrangement
  whatsoever in such amounts, at such costs, and upon such other terms and conditions as the Board of
  Directors shall deem appropriate.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#147;5.5 RELIANCE UPON PROVISIONS. Each person who shall act as an authorized representative
  of the Corporation shall be deemed to be doing so in reliance upon the rights of indemnification
  provided by this Article.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#147;5.6 AMENDMENT OR REPEAL. All rights of indemnification under this Article shall be
  deemed a contract between the Corporation and the person entitled to indemnification under this
  Article pursuant to which the Corporation and each such person intend to be legally bound. Any
  repeal, amendment or modification hereof shall be prospective only and shall not limit, but may
  expand, any rights or obligations in respect of any proceeding whether commenced prior to or after
  such change to the extent such proceeding pertains to actions or failures to act occurring prior to
  such change.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&#147;5.7 SCOPE OF ARTICLE. The indemnification, as authorized by this Article, shall not be
  deemed exclusive of any other rights to which those seeking indemnification or advancement of
  expenses may be entitled under any statute, agreement, vote of shareholders or disinterested
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">directors or otherwise, both as to action in an official capacity and as to action in any other
  capacity while holding such office. The indemnification and advancement of expenses provided by, or
  granted pursuant to, this Article shall continue as to a person who has ceased to be an officer,
  director, employee or agent in respect of matters arising prior to such time, and shall inure to
  the benefit of the heirs, executors and administrators of such person.&#148;
  </DIV>
  
  <!-- link2 "Item&nbsp;7. Exemption From Registration Claimed" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;7. <u>Exemption From Registration Claimed</u>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;8. <u>Exhibits</u>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;See the Exhibit&nbsp;Index on the page immediately preceding the exhibits for a list of exhibits
  filed as part of this Registration Statement on Form S-8, which Exhibit&nbsp;Index is incorporated
  herein by reference.
  </DIV>
  <!-- link2 "Item&nbsp;9. Undertakings" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;9. <u>Undertakings</u>.
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">(a)&nbsp;The undersigned Registrant hereby undertakes:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of the Securities
  Act of 1933;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental
  change in the information set forth in the Registration Statement. Notwithstanding
  the foregoing, any increase or decrease in volume of securities offered (if the
  total dollar value of securities offered would not exceed that which was
  registered) and any deviation from the low or high end of the estimated maximum
  offering range may be reflected in the form of prospectus filed with the Commission
  pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price
  represent no more than 20% change in the maximum aggregate offering price set forth
  in the &#147;Calculation of Registration Fee&#148; table in the effective Registration
  Statement;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or any material
  change to such information in the Registration Statement;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 6%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>provided</I>, <I>however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if
  the Registration Statement is on Form S-8, and the information required to be
  included in a post-effective amendment by those paragraphs is contained in reports
  filed with or furnished to the Commission by the Registrant pursuant to Section&nbsp;13
  or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by
  reference in the Registration Statement.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act of
  1933, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such
  securities at that time shall be deemed to be the initial bona fide offering thereof.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the offering.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">(b)&nbsp;The undersigned Registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act of 1933, each filing of the
  Registrant&#146;s annual report pursuant to Section 13(a) or Section 15(d) of the
  Securities Exchange Act of 1934 (and, where applicable, each filing of an
  employee benefit plan&#146;s annual report pursuant to Section 15(d) of the Exchange
  Act of 1934) that is incorporated by reference in the Registration Statement
  shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be
  deemed to be the initial <I>bona fide </I>offering thereof.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">(c)&nbsp;Insofar as indemnification for liabilities arising under the Securities Act
  of 1933 may be permitted to directors, officers and controlling persons of the
  Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
  has been advised that in the opinion of the Securities and Exchange Commission
  such indemnification is against public policy as expressed in the Act and is,
  therefore, unenforceable. In the event that a claim for indemnification against
  such liabilities (other than the payment by the Registrant of expenses incurred
  or paid by a director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such
  director, officer or controlling person in connection with the securities being
  registered, the Registrant will, unless in the opinion of its counsel the
  matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is
  against public policy as expressed in the Act and will be governed by the final
  adjudication of such issue.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "SIGNATURES" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, the Company certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Cambridge, in the Commonwealth of Massachusetts, on this 9th day of
  February&nbsp;2009.
  </DIV>
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">
  ALKERMES, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">
  
  /s/ David A. Broecker
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">David A. Broecker&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>POWER OF ATTORNEY AND SIGNATURES</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been
  signed below by the following persons in the capacities and on the dates indicated.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Each person whose signature appears below in so signing also makes, constitutes and appoints David
  A. Broecker and James M. Frates, and each of them, his true and lawful attorney-in-fact, with full
  power of substitution, for him in any and all capacities, to execute and cause to be filed with the
  Securities and Exchange Commission any and all amendments and post-effective amendments to this
  Registration Statement, with exhibits thereto and other documents in connection therewith, and
  hereby ratifies and confirms all that said attorney-in-fact or his substitute or substitutes may do
  or cause to be done by virtue hereof.
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>SIGNATURE</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>TITLE</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>DATE</B></TD>
  </TR>
  <TR valign="top"><!-- Blank Space -->
   <TD><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD></TR>
  
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ Richard F. Pops
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director and Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Richard F. Pops</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ David A. Broecker
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">President and Chief Executive Officer
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">David A. Broecker
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(Principal Executive Officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ James M. Frates
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Senior Vice President, Chief Financial
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  James M. Frates
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Officer and Treasurer<BR>
  (Principal Financial and Accounting Officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ David W. Anstice
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">David W. Anstice</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ Floyd E. Bloom
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Floyd E. Bloom</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ Robert A. Breyer
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Robert A. Breyer</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ Gerri Henwood
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Gerri Henwood</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ Paul J. Mitchell
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Paul J. Mitchell</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ Alexander Rich
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Alexander Rich</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ Mark B. Skaletsky
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Mark B. Skaletsky</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">/s/ Michael A. Wall
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director and Chairman Emeritus
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">February&nbsp;9, 2009</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Michael A. Wall</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "INDEX TO EXHIBITS" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX TO EXHIBITS</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="80%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000">No.</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000">Description of Exhibit</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Third Amended and Restated Articles of Incorporation as filed with the Pennsylvania Secretary of State on
  June&nbsp;7, 2001. (Incorporated by reference to Exhibit&nbsp;3.1 to the Registrant&#146;s Report on Form&nbsp;10-K for the
  fiscal year ended March&nbsp;31, 2001 (File No.&nbsp;001-14131).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amendment to Third Amended and Restated Articles of Incorporation as filed with the Pennsylvania Secretary
  of State on December&nbsp;16, 2002 (2002 Preferred Stock Terms). (Incorporated by reference to Exhibit&nbsp;3.1 to
  the Registrant&#146;s Current Report on Form&nbsp;8-K filed on December&nbsp;16, 2002 (File No.&nbsp;001-14131).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amendment to Third Amended and Restated Articles of Incorporation as filed with the Pennsylvania Secretary
  of State on May&nbsp;14, 2003 (Incorporated by reference to Exhibit&nbsp;A to Exhibit&nbsp;4.1 to the Registrant&#146;s Report
  on Form&nbsp;8-A filed on May&nbsp;2, 2003 (File No.&nbsp;000-19267).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Second Amended and Restated By-Laws of Alkermes, Inc. (Incorporated by reference to Exhibit&nbsp;3.2 to the
  Registrant&#146;s Current Report on Form&nbsp;8-K filed on September&nbsp;28, 2005.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by reference to Exhibit&nbsp;4 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;033-40250).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.6
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, dated as of February&nbsp;7, 2003, as amended, between Alkermes, Inc. and EquiServe Trust Co.,
  N.A., as Rights Agent. (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Report on Form&nbsp;8-A
  filed May&nbsp;2, 2003 (File No.&nbsp;000-19267).)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Ballard Spahr Andrews &#038; Ingersoll, LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ballard Spahr Andrews &#038; Ingersoll, LLP (included in Exhibit&nbsp;5.1).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included in signature page).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Alkermes, Inc. 2008 Stock Option and Incentive Plan (Incorporated by reference to Exhibit&nbsp;10.1
  to the Registrant&#146;s Current Report on Form&nbsp;8-K filed on October&nbsp;7, 2008.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Alkermes, Inc. 2008 Stock Option and Incentive Plan, Stock Option Award Certificate (Incentive
  Stock Option). (Incorporated by reference to Exhibit&nbsp;10.2 to the Registrant&#146;s Report on Form
  8-K filed on October&nbsp;7, 2008.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Alkermes, Inc. 2008 Stock Option and Incentive Plan, Stock Option Award Certificate
  (Non-Qualified Option). (Incorporated by reference to Exhibit&nbsp;10.3 to the Registrant&#146;s Report
  on Form&nbsp;8-K filed on October&nbsp;7, 2008.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
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      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Alkermes, Inc. 2008 Stock Option and Incentive Plan, Stock Option Award Certificate
  (Non-Employee Director). (Incorporated by reference to Exhibit&nbsp;10.4 to the Registrant&#146;s Report
  on Form&nbsp;8-K filed on October&nbsp;7, 2008.)</TD>
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metadata_filer: {"company-data": {"conformed-name": "ALKERMES INC", "cik": "0000874663", "assigned-sic": "2834", "irs-number": "232472830", "state-of-incorporation": "PA", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-157194", "film-number": "09581853"}, "business-address": {"street1": "88 SIDNEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02139-4136", "phone": "617-494-0171"}}
text: sv8
  As filed with the Securities and Exchange Commission on February 9, 2009
  Registration No. 333-
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER
  THE SECURITIES ACT OF 1933
  ALKERMES, INC.
  (Exact Name of Company as specified in its charter)
  Pennsylvania
  23-2472830
  (State or other jurisdiction of incorporation or organization)
  (I.R.S. Employer Identification No.)
  ALKERMES, INC.
  88 SIDNEY STREET
  CAMBRIDGE, MASSACHUSETTS 02139-4234
  (Address, including zip code, of registrant's principal executive offices)
  ALKERMES, INC. 2008 STOCK OPTION AND INCENTIVE PLAN
  (Full title of the plan)
  David A. Broecker
  Chief Executive Officer
  ALKERMES, INC.
  88 Sidney Street
  Cambridge, Massachusetts 02139-4234
  Telephone: (617) 494-0171
  (Name, address, including zip code, and telephone number, including area code,
  of agent for service)
  Copies to:
  Mitchell S. Bloom, Esq.
  Kathryn L. Biberstein, Esq.
  Robert E. Puopolo, Esq.
  Alkermes, Inc.
  Goodwin Procter LLP
  88 Sidney Street
  53 State Street
  Cambridge, MA 02139
  Boston, MA 02109
  Telephone: (617) 583-6255
  Telephone: (617) 570-1000
  Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer,
  or a non-accelerated filer. See definition of "accelerated filer and large accelerated filer" in
  Rule 12b-2 of the Exchange Act.
  Large accelerated filer
  þ
  Accelerated filer
  o
  Non-accelerated filer
  o
  Smaller reporting company
  o
  (Do not check if a smaller reporting company)
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  Maximum
  Maximum
  Amount
  Offering
  Aggregate
  to be
  Price Per
  Offering
  Amount of
  Title of Securities to be registered
  Registered (2) (5)
  Share
  Price
  Registration Fee
  Common Stock, par value $0.01 per share(1)
  258,000
  (3)
  $
  11.44
  $
  2,951,520
  Common Stock, par value $0.01 per share(1)
  109,000
  (3)
  10.10
  1,100,900
  Common Stock, par value $0.01 per share(1)
  7,000
  (3)
  10.71
  74,970
  Common Stock, par value $0.01 per share(1)
  313,000
  (3)
  11.98
  3,749,740
  Common Stock, par value $0.01 per share(1)
  25,760,858
  (4)
  11.04
  284,399,873
  Total:
  26,447,858
  $
  292,277,003
  $
  11,487
  (1)
  This Registration Statement also relates to the Rights to purchase
  shares of Series A Junior Participating Preferred Stock of the
  Registrant which are attached to all shares of Common Stock pursuant
  to the terms of the Registrant's Rights Agreement dated February 7,
  2003. Until the occurrence of certain prescribed events, the Rights
  are not exercisable, are evidenced by the certificates for the Common
  Stock and will be transferred only with such stock.
  (2)
  Pursuant to Rule 416(c) under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend, recapitalization, and certain other
  capital adjustments and the like.
  (3)
  Such shares are issuable upon the exercise of outstanding options with
  fixed exercise prices. Pursuant to Rule 457(h), the aggregate offering
  price and fee have been computed upon the basis of the price at which
  such options may be exercised. The offering price per share set forth
  for such shares is the exercise price per share at which such options
  are exercisable.
  (4)
  Estimated solely for the purpose of calculating the registration fee.
  In accordance with Rules 457(c) and 457(h), the proposed maximum
  offering price per share, the proposed maximum aggregate offering
  price, and the registration fee shown has been computed based upon the
  average of the high and low sales price of the Company's Common Stock
  on February 6, 2009, $11.04, as reported on the Nasdaq Global Market
  with respect to securities for which options have not been granted.
  (5)
  The maximum number of shares of Common Stock reserved and available
  for issuance under the Plan includes: (i) 6,400,000 shares, plus
  (ii) up to 3,070,779 shares of Common Stock which were previously
  available for grant under the Alkermes, Inc. 1999 Stock Option Plan,
  the Alkermes, Inc. 2002 Restricted Stock Award Plan and the Alkermes,
  Inc. 2006 Stock Option Plan For Non-Employee Directors (together, the
  "Old Stock Plans") and now available for grant under the Plan, plus
  (iii) up to 16,977,079 shares of Common Stock underlying outstanding
  grants pursuant to the Old Stock Plans that may be available for grant
  under the Plan if they are forfeited, cancelled, repurchased or are
  terminated (other than by exercise).
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  Item 1.
  Plan Information
  .
  The documents containing the information specified in this Part I will be sent or given to
  employees, directors or others as specified by Rule 428(b)(1). In accordance with the rules and
  regulations of the Securities and Exchange Commission (the "Commission") and the Introductory Note
  to Part I of Form S-8, such documents are not being filed with the Commission either as part of
  this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424.
  Item 2.
  Registrant Information and Employee Plan Annual Information
  .
  The documents containing the information specified in this Part I will be sent or given to
  employees, directors or others as specified by Rule 428(b)(1). In accordance with the rules and
  regulations of the Commission and the Introductory Note to Part I of Form S-8, such documents are
  not being filed with the Commission either as part of this Registration Statement or as
  prospectuses or prospectus supplements pursuant to Rule 424.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference
  .
  The following documents filed with the Commission are incorporated by reference in this
  Registration Statement:
  (a)
  The Registrant's Annual Report on Form 10-K for the fiscal year ended March 31, 2008 filed with the Commission on May 30,
  2008;
  The Registrant's Quarterly Report on Form 10-Q for the three months ended June 30, 2008 filed with the Commission on
  August 7, 2008;
  The Registrant's Quarterly Report on Form 10-Q for the three months ended September 30, 2008 filed with the Commission on
  November 7, 2008;
  The Registrant's Quarterly Report on Form 10-Q for the three months ended December 31, 2008 filed with the Commission on
  February 9, 2009;
  The Registrant's Current Reports on Forms 8-K filed with the Commission on May 16, 2008; May 28, 2008; June 16, 2008 (
  Item
  8.01 only
  ); October 7, 2008; November 4, 2008; and December 1, 2008 (
  Item 1.02 only
  ).
  (b)
  All other reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange
  Act "), since March 31, 2008; and
  (c)
  Item 1 of Registration Statement of the Company on Form 8-A dated June 28, 1991, as amended by a Registration Statement of
  the Company on Form 8-A/A dated January 17, 1997; and Item 1 of Registration Statement of the Company on Form 8-A dated
  May 2, 2003.
  All documents filed by the Company pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange
  Act, after the date of this Registration Statement and prior to the filing of a post-effective
  amendment which indicates that all securities offered herein have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing such documents. Any statement contained herein or in a
  document incorporated by reference or deemed to be incorporated by reference herein shall be deemed
  to be modified or superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document which is incorporated
  or is deemed to be incorporated by reference herein. Any such statement so modified or superseded
  shall not be deemed, except as so modified or superseded, to constitute a part of this Registration
  Statement.
  Item 4.
  Description of Securities
  .
  Not applicable.
  Item 5.
  Interests of Named Experts and Counsel
  .
  Not applicable.
  Item 6.
  Indemnification of Directors and Officers
  .
  The Pennsylvania Business Corporation Law of 1988, as amended, authorizes the Company to grant
  indemnification to directors and officers in terms sufficiently broad to permit such
  indemnification under certain circumstances for liabilities (including reimbursement for expenses
  incurred) arising under the Securities Act of 1933, as amended. The Company has also obtained
  Directors' and Officers' Liability Insurance which insures its officers and directors against
  certain liabilities such persons may incur in their capacities as officers or directors of the
  Company. In addition, the Company's By-laws contain the following provisions:
  "5.1 INDEMNIFICATION OF DIRECTORS, OFFICERS, AND OTHER PERSONS. The Corporation shall
  indemnify any director, officer, employee or agent of the Corporation or any of its subsidiaries
  who was or is an "authorized representative" of the Corporation (which shall mean, for the purpose
  of this Article, a director or officer of the Corporation, or a person serving at the request of
  the Corporation as a director, officer, partner, fiduciary or trustee of another corporation,
  partnership, joint venture, trust, employee benefit plan or other enterprise) and who was or is a
  "party" (which shall include for purposes of this Article the giving of testimony or similar
  involvement) or is threatened to be made a party to any "proceeding" (which shall mean for purposes
  of this Article any threatened, pending or completed action, suit, appeal or other proceeding of
  any nature, whether civil, criminal, administrative or investigative, whether formal or informal,
  and whether brought by or in the right of the Corporation, its shareholders or otherwise) by reason
  of the fact that such person was or is an authorized representative of the Corporation to the
  fullest extent permitted by law, including without limitation indemnification against expenses
  (which shall include for purposes of this Article attorneys' fees and disbursements), damages,
  punitive damages, judgments, penalties, fines and amounts paid in settlement actually and
  reasonably incurred by such person in connection with such proceeding unless the act or failure to
  act giving rise to the claim is finally determined by a court to have constituted willful
  misconduct or recklessness. If an authorized representative is not entitled to indemnification in
  respect of a portion of any liabilities to which such person may be subject, the Corporation shall
  nonetheless indemnify such person to the maximum extent for the remaining portion of the
  liabilities.
  "5.2 ADVANCEMENT OF EXPENSES. The Corporation shall pay the expenses (including
  attorneys' fees and disbursements) actually and reasonably incurred in defending a proceeding on
  behalf of any person entitled to indemnification under Section 5.1 in advance of the final
  disposition of such proceeding upon receipt of an undertaking by or on behalf of such person to
  repay such amount if it shall ultimately be determined that such person is not entitled to be
  indemnified by the Corporation as authorized in this Article and may pay such expenses in advance
  on behalf of any employee or agent on receipt of a similar undertaking. The financial ability of
  such authorized representative to make such repayment shall not be prerequisite to the making of an
  advance.
  "5.3 EMPLOYEE BENEFIT PLANS. For purposes of this Article, the Corporation shall be
  deemed to have requested an officer, director, employee or agent to serve as fiduciary with respect
  to an employee benefit plan where the performance by such person of duties to the Corporation also
  imposes duties on, or otherwise involves services by, such person as a fiduciary with respect to
  the plan; excise taxes assessed on an authorized representative with respect to any transaction
  with an employee benefit plan shall be deemed "fines"; and action taken or omitted by such person
  with respect to an employee benefit plan in the performance of duties for a purpose reasonably
  believed to be in the interest of the participants and beneficiaries of the plan shall be deemed to
  be for a purpose which is not opposed to the best interests of the Corporation.
  "5.4 SECURITY FOR INDEMNIFICATION OBLIGATIONS. To further effect, satisfy or secure the
  indemnification obligations provided herein or otherwise, the Corporation may maintain insurance,
  obtain a letter of credit, act as self-insurer, create a reserve, trust, escrow, cash collateral or
  other fund or account, enter into indemnification agreements, pledge or grant a security interest
  in any assets or properties of the Corporation, or use any other mechanism or arrangement
  whatsoever in such amounts, at such costs, and upon such other terms and conditions as the Board of
  Directors shall deem appropriate.
  "5.5 RELIANCE UPON PROVISIONS. Each person who shall act as an authorized representative
  of the Corporation shall be deemed to be doing so in reliance upon the rights of indemnification
  provided by this Article.
  "5.6 AMENDMENT OR REPEAL. All rights of indemnification under this Article shall be
  deemed a contract between the Corporation and the person entitled to indemnification under this
  Article pursuant to which the Corporation and each such person intend to be legally bound. Any
  repeal, amendment or modification hereof shall be prospective only and shall not limit, but may
  expand, any rights or obligations in respect of any proceeding whether commenced prior to or after
  such change to the extent such proceeding pertains to actions or failures to act occurring prior to
  such change.
  "5.7 SCOPE OF ARTICLE. The indemnification, as authorized by this Article, shall not be
  deemed exclusive of any other rights to which those seeking indemnification or advancement of
  expenses may be entitled under any statute, agreement, vote of shareholders or disinterested
  directors or otherwise, both as to action in an official capacity and as to action in any other
  capacity while holding such office. The indemnification and advancement of expenses provided by, or
  granted pursuant to, this Article shall continue as to a person who has ceased to be an officer,
  director, employee or agent in respect of matters arising prior to such time, and shall inure to
  the benefit of the heirs, executors and administrators of such person."
  Item 7.
  Exemption From Registration Claimed
  .
  Not applicable.
  Item 8.
  Exhibits
  .
  See the Exhibit Index on the page immediately preceding the exhibits for a list of exhibits
  filed as part of this Registration Statement on Form S-8, which Exhibit Index is incorporated
  herein by reference.
  Item 9.
  Undertakings
  .
  (a) The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:
  (i) To include any prospectus required by Section 10(a)(3) of the Securities
  Act of 1933;
  (ii) To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental
  change in the information set forth in the Registration Statement. Notwithstanding
  the foregoing, any increase or decrease in volume of securities offered (if the
  total dollar value of securities offered would not exceed that which was
  registered) and any deviation from the low or high end of the estimated maximum
  offering range may be reflected in the form of prospectus filed with the Commission
  pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price
  represent no more than 20% change in the maximum aggregate offering price set forth
  in the "Calculation of Registration Fee" table in the effective Registration
  Statement;
  (iii) To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or any material
  change to such information in the Registration Statement;
  provided
  ,
  however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if
  the Registration Statement is on Form S-8, and the information required to be
  included in a post-effective amendment by those paragraphs is contained in reports
  filed with or furnished to the Commission by the Registrant pursuant to Section 13
  or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by
  reference in the Registration Statement.
  (2) That, for the purpose of determining any liability under the Securities Act of
  1933, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such
  securities at that time shall be deemed to be the initial bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the offering.
  (b) The undersigned Registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act of 1933, each filing of the
  Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
  Securities Exchange Act of 1934 (and, where applicable, each filing of an
  employee benefit plan's annual report pursuant to Section 15(d) of the Exchange
  Act of 1934) that is incorporated by reference in the Registration Statement
  shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be
  deemed to be the initial
  bona fide
  offering thereof.
  (c) Insofar as indemnification for liabilities arising under the Securities Act
  of 1933 may be permitted to directors, officers and controlling persons of the
  Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
  has been advised that in the opinion of the Securities and Exchange Commission
  such indemnification is against public policy as expressed in the Act and is,
  therefore, unenforceable. In the event that a claim for indemnification against
  such liabilities (other than the payment by the Registrant of expenses incurred
  or paid by a director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such
  director, officer or controlling person in connection with the securities being
  registered, the Registrant will, unless in the opinion of its counsel the
  matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is
  against public policy as expressed in the Act and will be governed by the final
  adjudication of such issue.
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Company certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the City of Cambridge, in the Commonwealth of Massachusetts, on this 9th day of
  February 2009.
  ALKERMES, INC.
  By:
  /s/ David A. Broecker
  David A. Broecker
  Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been
  signed below by the following persons in the capacities and on the dates indicated.
  Each person whose signature appears below in so signing also makes, constitutes and appoints David
  A. Broecker and James M. Frates, and each of them, his true and lawful attorney-in-fact, with full
  power of substitution, for him in any and all capacities, to execute and cause to be filed with the
  Securities and Exchange Commission any and all amendments and post-effective amendments to this
  Registration Statement, with exhibits thereto and other documents in connection therewith, and
  hereby ratifies and confirms all that said attorney-in-fact or his substitute or substitutes may do
  or cause to be done by virtue hereof.
  SIGNATURE
  TITLE
  DATE
  /s/ Richard F. Pops
  Director and Chairman of the Board
  February 9, 2009
  Richard F. Pops
  /s/ David A. Broecker
  President and Chief Executive Officer
  February 9, 2009
  David A. Broecker
  (Principal Executive Officer)
  /s/ James M. Frates
  Senior Vice President, Chief Financial
  February 9, 2009
  James M. Frates
  Officer and Treasurer
  (Principal Financial and Accounting Officer)
  /s/ David W. Anstice
  Director
  February 9, 2009
  David W. Anstice
  /s/ Floyd E. Bloom
  Director
  February 9, 2009
  Floyd E. Bloom
  /s/ Robert A. Breyer
  Director
  February 9, 2009
  Robert A. Breyer
  /s/ Gerri Henwood
  Director
  February 9, 2009
  Gerri Henwood
  /s/ Paul J. Mitchell
  Director
  February 9, 2009
  Paul J. Mitchell
  /s/ Alexander Rich
  Director
  February 9, 2009
  Alexander Rich
  /s/ Mark B. Skaletsky
  Director
  February 9, 2009
  Mark B. Skaletsky
  /s/ Michael A. Wall
  Director and Chairman Emeritus
  February 9, 2009
  Michael A. Wall
  INDEX TO EXHIBITS
  Exhibit
  No.
  Description of Exhibit
  4.1
  Third Amended and Restated Articles of Incorporation as filed with the Pennsylvania Secretary of State on
  June 7, 2001. (Incorporated by reference to Exhibit 3.1 to the Registrant's Report on Form 10-K for the
  fiscal year ended March 31, 2001 (File No. 001-14131).)
  4.2
  Amendment to Third Amended and Restated Articles of Incorporation as filed with the Pennsylvania Secretary
  of State on December 16, 2002 (2002 Preferred Stock Terms). (Incorporated by reference to Exhibit 3.1 to
  the Registrant's Current Report on Form 8-K filed on December 16, 2002 (File No. 001-14131).)
  4.3
  Amendment to Third Amended and Restated Articles of Incorporation as filed with the Pennsylvania Secretary
  of State on May 14, 2003 (Incorporated by reference to Exhibit A to Exhibit 4.1 to the Registrant's Report
  on Form 8-A filed on May 2, 2003 (File No. 000-19267).)
  4.4
  Second Amended and Restated By-Laws of Alkermes, Inc. (Incorporated by reference to Exhibit 3.2 to the
  Registrant's Current Report on Form 8-K filed on September 28, 2005.)
  4.5
  Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by reference to Exhibit 4 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 033-40250).)
  4.6
  Rights Agreement, dated as of February 7, 2003, as amended, between Alkermes, Inc. and EquiServe Trust Co.,
  N.A., as Rights Agent. (Incorporated by reference to Exhibit 4.1 to the Registrant's Report on Form 8-A
  filed May 2, 2003 (File No. 000-19267).)
  5.1
  Opinion of Ballard Spahr Andrews & Ingersoll, LLP (filed herewith).
  23.1
  Consent of Ballard Spahr Andrews & Ingersoll, LLP (included in Exhibit 5.1).
  23.2
  Consent of PricewaterhouseCoopers LLP (filed herewith).
  23.3
  Consent of Deloitte & Touche LLP (filed herewith).
  24.1
  Power of Attorney (included in signature page).
  99.1
  Alkermes, Inc. 2008 Stock Option and Incentive Plan (Incorporated by reference to Exhibit 10.1
  to the Registrant's Current Report on Form 8-K filed on October 7, 2008.)
  99.2
  Alkermes, Inc. 2008 Stock Option and Incentive Plan, Stock Option Award Certificate (Incentive
  Stock Option). (Incorporated by reference to Exhibit 10.2 to the Registrant's Report on Form
  8-K filed on October 7, 2008.)
  99.3
  Alkermes, Inc. 2008 Stock Option and Incentive Plan, Stock Option Award Certificate
  (Non-Qualified Option). (Incorporated by reference to Exhibit 10.3 to the Registrant's Report
  on Form 8-K filed on October 7, 2008.)
  99.4
  Alkermes, Inc. 2008 Stock Option and Incentive Plan, Stock Option Award Certificate
  (Non-Employee Director). (Incorporated by reference to Exhibit 10.4 to the Registrant's Report
  on Form 8-K filed on October 7, 2008.)