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  <H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>As filed with the Securities and Exchange Commission on November&nbsp;21, 2005<BR>
  Registration No.&nbsp;333-</B></DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT<BR>
  UNDER<BR>
  THE SECURITIES ACT OF 1933</B></DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>CALIPER LIFE SCIENCES, INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>33-0675808</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or other Jurisdiction of</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Incorporation or Organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>68 ELM STREET<BR>
  HOPKINTON, MA 01748</B><BR>
  (Address of principal executive offices, including zip code)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>1999 EMPLOYEE STOCK PURCHASE PLAN</B><BR>
  (Full title of plan)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>E. Kevin Hrusovsky<BR>
  President and Chief Executive Officer<BR>
  Caliper Life Sciences, Inc.<BR>
  68 Elm Street<BR>
  Hopkinton, MA 01748<BR>
  (508)&nbsp;435-9500</B><BR>
  (Name, address, including zip code, and telephone number, including area code, of agent for service)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Copies to:<BR>
  William T. Whelan, Esq.<BR>
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.<BR>
  One Financial Center<BR>
  Boston, Massachusetts 02111<BR>
  (617)&nbsp;542-6000</B></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>CALCULATION OF REGISTRATION FEE</B></DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center"><B>Title of Each Class of</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed Maximum</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed Maximum</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center"><B>Securities</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Offering</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Aggregate</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center"><B>to be Registered</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount to be Registered</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Price per Share</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Offering Price</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Registration Fee</B></TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock (par
  value $0.001)</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">292,161</TD>
      <TD nowrap style="border-top: 2px solid #000000">(1)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">$</TD>
  
  <TD align="right" style="border-top: 2px solid #000000">7.13</TD>
      <TD nowrap style="border-top: 2px solid #000000">(2)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">$</TD>
  
  <TD align="right" style="border-top: 2px solid #000000">2,083,107.93</TD>
      <TD nowrap style="border-top: 2px solid #000000">(2)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">$</TD>
  
  <TD align="right" style="border-top: 2px solid #000000">245.18</TD>
      <TD nowrap style="border-top: 2px solid #000000">(2)</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:30px; text-indent:-15px">Preferred Share
  Purchase Rights</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">292,161</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">(3</TD>
      <TD nowrap style="border-top: 2px solid #000000">)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">(3</TD>
      <TD nowrap style="border-top: 2px solid #000000">)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">(3</TD>
      <TD nowrap style="border-top: 2px solid #000000">)</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px solid #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV style="margin-top: 3pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>292,161 shares to be registered pursuant to the 1999 Employee Stock Purchase Plan. This
  Registration Statement shall cover any additional shares of Common Stock which become issuable
  under the plan set forth herein by reason of any stock dividend, stock split, recapitalization
  or any other similar transaction without receipt of consideration which results in an increase
  in the number of shares of the Registrant&#146;s outstanding Common Stock.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of calculating the amount of the registration fee pursuant
  to Rule&nbsp;457(h). The price per share and aggregate offering price of the shares to be offered
  under the plan are based upon the average of the high and low prices of the Registrant&#146;s
  Common Stock on November&nbsp;18, 2005 as reported on the Nasdaq National Market (pursuant to Rule
  457(c) under the Act) for shares reserved for future issuance under the plans.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>Preferred Share Purchase Rights, which are attached to the shares of Common Stock to be
  issued but do not trade separately from the shares of Common Stock until a triggering event.
  No additional offering price attaches to these rights.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="left">
  <!-- TOC -->
  </DIV>
  <DIV align="left">
  <A name="tocpage"></A>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>TABLE OF CONTENTS</B></U>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="10%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="89%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><A href="#101">Item&nbsp;3.
  </A></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><A href="#101">Incorporation of Documents by Reference</A></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><A href="#102">Item&nbsp;4.
  </A></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><A href="#102">Description of Securities</A></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><A href="#103">Item&nbsp;5.
  </A></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><A href="#103">Interests of Named Experts and Counsel</A></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><A href="#104">Item&nbsp;6.
  </A></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><A href="#104">Indemnification of Directors and Officers</A></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><A href="#105">Item&nbsp;7.
  </A></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><A href="#105">Exemption From Registration Claimed</A></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><A href="#106">Item&nbsp;8.
  </A></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><A href="#106">Exhibits</A></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><A href="#107">Item&nbsp;9.
  </A></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><A href="#107">Undertakings</A></TD>
  </TR>
  <TR valign="bottom">
      <TD colspan="3" valign="top" align="left"><A href="#108">Signatures</A></TD>
  </TR>
  <TR valign="bottom">
      <TD colspan="3" valign="top" align="left">Power of Attorney</TD>
  </TR>
  <!-- End Table Body -->
  <TR><TD colspan="9"><FONT size="2">&nbsp;<A HREF="b57897lsexv5w1.htm">EX-5.1 - Opinion of Mintz, Levin, Cohn, Ferris & Popeo, P.C.</A></FONT></TD></TR>
  <TR><TD colspan="9"><FONT size="2">&nbsp;<A HREF="b57897lsexv23w1.htm">EX-23.1 - Consent of Ernst & Young LLP</A></FONT></TD></TR>
  </TABLE>
  </DIV>
  
  <DIV align="left">
  <!-- /TOC -->
  </DIV>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U>EXPLANATORY NOTES</U>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">1. In accordance with General Instruction E to Part&nbsp;I of Form S-8 as promulgated by the
  Securities and Exchange
  Commission, the information specified by Part&nbsp;I of Form S-8 has been omitted from this Registration
  Statement on Form S-8 for offers of Common Stock pursuant to the Registrant&#146;s 1999 Employee
  Stock Purchase Plan.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">2. The contents of the previously filed Registration Statements on Form S-8
  (File Nos. 333-117273, 333-106436, 333-91276, 333-69722, 333-40466 and 333-95007) of the Registrant
  are hereby incorporated by reference. The purpose of this Form S-8 is to reflect an increase in
  the number of shares authorized for issuance under the 1999 Employee Stock Purchase Plan.
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The document(s) containing the information specified in Part&nbsp;I will be sent or given to
  employees as specified by Rule&nbsp;428(b)(1) of the Securities Act of 1933, as amended (the &#147;Securities
  Act&#148;). Such documents are not being filed with the Securities and Exchange Commission (the
  &#147;Commission&#148;) either as part of this Registration Statement or as prospectuses or prospectus
  supplements pursuant to Rule&nbsp;424 of the Securities Act. Such documents and the documents
  incorporated by reference in this Registration Statement pursuant to Item&nbsp;3 of Part&nbsp;II of this
  Form, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the
  Securities Act.
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  </DIV>
  
  <DIV align="left">
  <A name="101"></A>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by Caliper Life Sciences, Inc. (the &#147;Registrant&#148;) with the
  Commission are incorporated by reference into this Registration Statement:
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left"><B>(a)</B></TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December
  31, 2004, filed on March&nbsp;16, 2005 and amended on April&nbsp;29, 2005.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left"><B>(b)</B></TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Quarterly Reports on Form 10-Q for the quarters ended March
  31, 2005, June&nbsp;30, 2005 and September&nbsp;30, 2005 and Current Reports on Form 8-K filed
  February&nbsp;23, 2005, March&nbsp;16, 2005, April&nbsp;26, 2005, April&nbsp;28, 2005, September&nbsp;12, 2005,
  September&nbsp;28, 2005, October&nbsp;5, 2005 and October&nbsp;21, 2005.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left"><B>(c)</B></TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Registrant&#146;s Common Stock which is contained in the
  Registration Statement on Form 8-A, filed November&nbsp;22, 1999, under the Securities
  Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;), including any amendment or
  report filed for the purpose of updating such description.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents subsequently filed by the Registrant pursuant to Sections
  13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment
  which indicates that all securities offered have been sold or which deregisters all securities then
  remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this
  Registration Statement from the date of the filing of such reports and documents.
  </DIV>
  <DIV align="left">
  <A name="102"></A>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>ITEM 4. DESCRIPTION OF SECURITIES</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Preferred Share Purchase Rights (the &#147;Rights&#148;) are not currently registered under the
  Exchange Act. Each share of Common Stock issued or outstanding has attached to it a Right. Each
  Right entitles the registered
  </DIV>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">holder to purchase from Caliper one one-hundredth of a share of
  Series&nbsp;A Junior Participating Preferred Stock, par value $0.001 per share (the &#147;Preferred Shares&#148;),
  at a price of $100.00 per one one-hundredth of a Preferred Share (the &#147;Purchase Price&#148;), subject to
  adjustment. Each one one-hundredth of a share of Preferred Shares has designations and powers,
  preferences and rights, and the qualifications, limitations and restrictions which make its value
  approximately equal to the value of a Common Share.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Rights are currently evidenced by the stock certificates representing the Common Shares
  outstanding, and no separate Right Certificates, as defined, have been distributed. Until the
  earlier to occur of (i)&nbsp;subject to limited exceptions, the date of a public announcement that a
  person, entity or group of affiliated or associated persons have acquired beneficial ownership of
  15% or more of the outstanding Common Shares (an &#147;Acquiring Person&#148;) or (ii)&nbsp;10 business days (or
  such later date as may be determined by action of the Board of Directors prior to such time as any
  person or entity becomes an Acquiring Person) following the commencement of, or announcement of an
  intention to commence, a tender offer or exchange offer the consummation of which would result in
  any person or entity becoming an Acquiring Person (the earlier of such dates being called the
  &#147;Distribution Date&#148;), the Rights will be evidenced, with respect to any of the Common Share
  certificates, by such Common Share certificate.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Until the Distribution Date, the Rights will be transferable with and only with the Common
  Shares. As soon as practicable following the Distribution Date, separate certificates evidencing
  the Rights (&#147;Right Certificates&#148;) will be mailed to holders of record of the Common Shares as of
  the close of business on the Distribution Date and such separate Right Certificates alone will
  evidence the Rights.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Rights are not exercisable until the Distribution Date. The Rights will expire on December
  17, 2011 (the &#147;Final Expiration Date&#148;), unless the Rights are earlier redeemed or exchanged by
  Caliper, in each case, as described below. The Rights are protected by customary anti-dilution
  provisions to protect the value of the Rights in the event of a stock dividend on, or a
  subdivision, combination or reclassification of, the Preferred Shares or the Common Stock, and in
  certain other events.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Preferred Shares purchasable upon exercise of the Rights will not be redeemable. Each
  Preferred Share will be entitled to a minimum preferential quarterly dividend payment of $1.00 but
  will be entitled to an aggregate dividend of 100 times the dividend declared per Common Share. In
  the event of liquidation, the holders of the Preferred Shares would be entitled to a minimum
  preferential liquidation payment of $100 per share, but would be entitled to receive an aggregate
  payment equal to 100 times the payment made per Common Share. Each Preferred Share will have 100
  votes, voting together with the Common Shares. Finally, in the event of any merger, consolidation
  or other transaction in which Common Shares are exchanged, each Preferred Share will be entitled to
  receive 100 times the amount of consideration received per Common Share. These rights are protected
  by customary anti-dilution provisions. Because of the nature of the Preferred Shares&#146; dividend and
  liquidation rights, the value of one one-hundredth of a Preferred Share should approximate the
  value of one Common Share. The Preferred Shares would rank junior to any other series of Caliper&#146;s
  preferred stock.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In the event that any person or group of affiliated or associated persons becomes an Acquiring
  Person, proper provision shall be made so that each holder of a Right, other than Rights
  beneficially owned by the Acquiring Person and its associates and affiliates (which will thereafter
  be void), will for a 60-day period have the right to receive upon exercise that number of Common
  Shares having a market value of two times the exercise price of the Right (or, if such number of
  shares is not and cannot be authorized, Caliper may issue Preferred Shares, cash, debt, stock or a
  combination thereof in exchange for the Rights). This right will terminate 60&nbsp;days after the date
  on which the Rights become nonredeemable (as described below), unless there is an injunction or
  similar obstacle to exercise of the Rights, in which event this right will terminate 60&nbsp;days after
  the date on which the Rights again become exercisable.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In the event that Caliper is acquired in a merger or other business combination transaction or
  50% or more of its consolidated assets or earning power are sold to an Acquiring Person, its
  associates or affiliates or certain other persons in which such persons have an interest, proper
  provision will be made so that each holder of a Right will thereafter have the right to receive,
  upon the exercise thereof at the then current exercise price of the Right, that number of shares of
  common stock of the acquiring company which at the time of such transaction will have a market
  value of two times the exercise price of the Right.
  </DIV>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;At any time after an Acquiring Person becomes an Acquiring Person and prior to the acquisition
  by such Acquiring Person of 50% or more of the outstanding Common Shares, the Board of Directors of
  Caliper may exchange the Rights (other than Rights owned by such person or group which have become
  void), in whole or in part, at an exchange ratio of one Common Share, or one one-hundredth of a
  Preferred Share, per Right (or, at the election of Caliper, Caliper may issue cash, debt, stock or
  a combination thereof in exchange for the Rights), subject to adjustment.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;At any time prior to the earliest of (i)&nbsp;the day of the first public announcement that a
  person has become an Acquiring Person or (ii)&nbsp;the Final Expiration Date, the Board of Directors of
  Caliper may redeem the Rights in whole, but not in part, at a price of $0.01 per Right (the
  &#147;Redemption Price&#148;). Following the expiration of the above periods, the Rights become
  nonredeemable. Immediately upon any redemption of the Rights, the right to exercise the Rights will
  terminate and the only right of the holders of Rights will be to receive the Redemption Price.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The terms of the Rights may be amended by the Board of Directors of Caliper without the
  consent of the holders of the Rights, except that from and after such time as the rights are
  distributed no such amendment may adversely affect the interest of the holders of the Rights
  excluding the interests of an Acquiring Person.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Until a Right is exercised, the holder thereof, as such, will have no rights as a stockholder
  of Caliper, including, without limitation, the right to vote or to receive dividends.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Rights have certain anti-takeover effects. The Rights will cause substantial dilution to a
  person or group that attempts to acquire Caliper on terms not approved by Caliper&#146;s Board of
  Directors. The Rights should not interfere with any merger or other business combination approved
  by the Board of Directors since the Rights may be amended to permit such acquisition or redeemed by
  Caliper at $0.01 per Right prior to the earliest of (i)&nbsp;the time that a person or group has
  acquired beneficial ownership of 15% or more of the Common Shares or (ii)&nbsp;the final expiration date
  of the rights.
  </DIV>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="left">
  <A name="103"></A>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. of Boston, Massachusetts.
  </DIV>
  <DIV align="left">
  <A name="104"></A>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporated herein by reference from Part&nbsp;II, Item&nbsp;15 of the Registrant&#146;s Registration
  Statement on Form S-3 (File No.&nbsp;333-129192) filed with the Commission on October&nbsp;21, 2005.
  </DIV>
  <DIV align="left">
  <A name="105"></A>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Not applicable.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
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  <H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV align="left">
  <A name="106"></A>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>ITEM 8. EXHIBITS</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="11%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="84%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B>Exhibit</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B>Number</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Description</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, independent registered public accounting firm.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  Reference is made to Exhibit&nbsp;5.1<FONT style="font-variant: SMALL-CAPS">.</FONT></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney. Reference is made to Signature Page.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.3(1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">1999 Employee Stock Purchase Plan.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  <DIV style="margin-top: 3pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="bottom">
  <TD colspan="3">
  <DIV style="width:18%; margin-top: 16px; font-size: 3pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  </TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Previously filed as the like-numbered Exhibit to the Registration Statement on Form&nbsp;S-8 (No.
  333-95007), and incorporated herein by reference.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  <DIV align="left">
  <A name="107"></A>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>ITEM 9. UNDERTAKINGS</B>
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">A.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes:</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="6%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(i)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To include any prospectus required by Section&nbsp;10(a)(3) of the
  Securities Act;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="6%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(ii)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To reflect in the prospectus any facts or events arising after
  the effective date of the Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate,
  represent a fundamental change in the information set forth in the Registration
  Statement. Notwithstanding the foregoing, any increase or decrease in volume
  of securities offered (if the total dollar value of securities offered would
  not exceed that which was registered) and any deviation from the low or high
  end of the estimated maximum offering range may be reflected in the form of
  prospectus filed with the Commission pursuant to Rule 424(b) if, in the
  aggregate, the changes in volume and price represent no more than a 20% change
  in the maximum aggregate offering price set forth in the &#147;Calculation of
  Registration Fee&#148; table in the effective Registration Statement.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="6%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(iii)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To include any material information with respect to the plan
  of distribution not previously disclosed in the Registration Statement or any
  material change to such information in the Registration Statement;</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however, </I>that paragraphs A(1)(i) and A(1)(ii) do not apply if the information
  required to be included in a post-effective amendment by those paragraphs is contained in periodic
  reports filed by the issuer pursuant to Section&nbsp;13 or Section 15(d) of the Exchange Act that are
  incorporated by reference herein.
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>That, for the purpose of determining any liability under the Securities Act,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that
  time shall be deemed to be the initial <I>bona fide </I>offering thereof.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the offering.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">B. The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act, each filing of the Registrant&#146;s annual report pursuant to Section 13(a)
  or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit
  plan&#146;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by
  reference in the Registration Statement shall be deemed to be a new registration statement relating
  to the securities offered therein, and the offering of such securities at that time shall be deemed
  to be the initial <I>bona fide </I>offering thereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to
  directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions,
  or otherwise, the Registrant has been advised that in the opinion of the Commission such
  indemnification is against public policy as expressed in the Securities Act and is, therefore,
  unenforceable. In the event that a claim for indemnification against such liabilities (other than
  the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
  person of the Registrant in the successful defense of any action, suit or proceeding) is asserted
  by such director, officer or controlling person in connection with the securities being registered,
  the Registrant will, unless in the opinion of its counsel the matter has been settled by
  controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities Act and will be
  governed by the final adjudication of such issue.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
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  <H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV align="left">
  <A name="108"></A>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, the Registrant certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the Town of Hopkinton, Commonwealth of Massachusetts, on November&nbsp;21, 2005.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="50%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="50%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Caliper Life Sciences, Inc.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By: /s/ E. Kevin Hrusovsky</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">E. Kevin Hrusovsky</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><I>President and Chief Executive Officer</I></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
  and appoints E. Kevin Hrusovsky, Thomas T. Higgins, Peter F. McAree and Stephen E. Creager, and
  each or any one of them, his true and lawful attorney-in-fact and agent, with full power of
  substitution and resubstitution, for him and in his name, place and stead, in any and all
  capacities, to sign any and all amendments (including post-effective amendments) to this
  Registration Statement, and to file the same, with all exhibits thereto, and other documents in
  connection therewith, with the Commission, granting unto said attorneys-in-fact and agents, and
  each of them, full power and authority to do and perform each and every act and thing requisite and
  necessary to be done in connection therewith, as fully to all intents and purposes as he might or
  could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or
  any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by
  virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  </DIV>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="28%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="45%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="20%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD>&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ E. Kevin Hrusovsky
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">President and Chief Executive Officer and Director</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;E. Kevin Hrusovsky
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">(<I>Principal Executive Officer</I>)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;November&nbsp;21,
  2005</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Thomas T. Higgins
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Executive Vice President and Chief Financial Officer</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Thomas T. Higgins
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">(<I>Principal Financial Officer</I>)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;November&nbsp;21,
  2005</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Peter F. McAree
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Vice President, Finance</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Peter F. McAree
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">(<I>Principal Accounting Officer</I>)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;November&nbsp;21,
  2005</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Daniel L. Kisner, M.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Daniel L. Kisner, M.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px"> Chairman of the Board of Directors
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;November&nbsp;21,
  2005</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ David V. Milligan, Ph.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;David V.
  Milligan, Ph.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Vice Chairman of the Board of Directors
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;November&nbsp;21,
  2005</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Van Billet
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Van Billet
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;November&nbsp;21,
  2005</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Robert C. Bishop, Ph.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Robert C.
  Bishop, Ph.D.
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;November&nbsp;21,
  2005</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Allan L. Comstock
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Allan L.Comstock
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;November&nbsp;21,
  2005</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Kathryn Tunstall
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="left" valign="top"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Kathryn Tunstall
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">Director
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;November&nbsp;21,
  2005</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>EXHIBIT INDEX</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="11%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="84%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B>Exhibit</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B>Number</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Description</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, independent registered public accounting firm.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  Reference is made to Exhibit&nbsp;5.1<FONT style="font-variant: SMALL-CAPS">.</FONT></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney. Reference is made to Signature Page.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.3(1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">1999 Employee Stock Purchase Plan.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  <DIV style="margin-top: 3pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR>
  <TD colspan="3">
  <DIV style="width:18%; margin-top: 16px; font-size: 3pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  </TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Previously filed as the like-numbered Exhibit to the Registration Statement on Form&nbsp;S-8 (No.
  333-95007), and incorporated herein by reference.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on November 21, 2005
  Registration No. 333-
  UNITED STATES SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  CALIPER LIFE SCIENCES, INC.
  (Exact name of registrant as specified in its charter)
  Delaware
  33-0675808
  (State or other Jurisdiction of
  (I.R.S. Employer Identification No.)
  Incorporation or Organization)
  68 ELM STREET
  HOPKINTON, MA 01748
  (Address of principal executive offices, including zip code)
  1999 EMPLOYEE STOCK PURCHASE PLAN
  (Full title of plan)
  E. Kevin Hrusovsky
  President and Chief Executive Officer
  Caliper Life Sciences, Inc.
  68 Elm Street
  Hopkinton, MA 01748
  (508) 435-9500
  (Name, address, including zip code, and telephone number, including area code, of agent for service)
  Copies to:
  William T. Whelan, Esq.
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  One Financial Center
  Boston, Massachusetts 02111
  (617) 542-6000
  CALCULATION OF REGISTRATION FEE
  Title of Each Class of
  Proposed Maximum
  Proposed Maximum
  Securities
  Offering
  Aggregate
  Amount of
  to be Registered
  Amount to be Registered
  Price per Share
  Offering Price
  Registration Fee
  Common Stock (par
  value $0.001)
  292,161
  (1)
  $
  7.13
  (2)
  $
  2,083,107.93
  (2)
  $
  245.18
  (2)
  Preferred Share
  Purchase Rights
  292,161
  (3
  )
  (3
  )
  (3
  )
  (1)
  292,161 shares to be registered pursuant to the 1999 Employee Stock Purchase Plan. This
  Registration Statement shall cover any additional shares of Common Stock which become issuable
  under the plan set forth herein by reason of any stock dividend, stock split, recapitalization
  or any other similar transaction without receipt of consideration which results in an increase
  in the number of shares of the Registrant's outstanding Common Stock.
  (2)
  Estimated solely for the purpose of calculating the amount of the registration fee pursuant
  to Rule 457(h). The price per share and aggregate offering price of the shares to be offered
  under the plan are based upon the average of the high and low prices of the Registrant's
  Common Stock on November 18, 2005 as reported on the Nasdaq National Market (pursuant to Rule
  457(c) under the Act) for shares reserved for future issuance under the plans.
  (3)
  Preferred Share Purchase Rights, which are attached to the shares of Common Stock to be
  issued but do not trade separately from the shares of Common Stock until a triggering event.
  No additional offering price attaches to these rights.
  TABLE OF CONTENTS
  Item 3.
  Incorporation of Documents by Reference
  Item 4.
  Description of Securities
  Item 5.
  Interests of Named Experts and Counsel
  Item 6.
  Indemnification of Directors and Officers
  Item 7.
  Exemption From Registration Claimed
  Item 8.
  Exhibits
  Item 9.
  Undertakings
  Signatures
  Power of Attorney
  EX-5.1 - Opinion of Mintz, Levin, Cohn, Ferris & Popeo, P.C.
  EX-23.1 - Consent of Ernst & Young LLP
  Table of Contents
  EXPLANATORY NOTES
  1. In accordance with General Instruction E to Part I of Form S-8 as promulgated by the
  Securities and Exchange
  Commission, the information specified by Part I of Form S-8 has been omitted from this Registration
  Statement on Form S-8 for offers of Common Stock pursuant to the Registrant's 1999 Employee
  Stock Purchase Plan.
  2. The contents of the previously filed Registration Statements on Form S-8
  (File Nos. 333-117273, 333-106436, 333-91276, 333-69722, 333-40466 and 333-95007) of the Registrant
  are hereby incorporated by reference. The purpose of this Form S-8 is to reflect an increase in
  the number of shares authorized for issuance under the 1999 Employee Stock Purchase Plan.
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  The document(s) containing the information specified in Part I will be sent or given to
  employees as specified by Rule 428(b)(1) of the Securities Act of 1933, as amended (the "Securities
  Act"). Such documents are not being filed with the Securities and Exchange Commission (the
  "Commission") either as part of this Registration Statement or as prospectuses or prospectus
  supplements pursuant to Rule 424 of the Securities Act. Such documents and the documents
  incorporated by reference in this Registration Statement pursuant to Item 3 of Part II of this
  Form, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the
  Securities Act.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE
  The following documents filed by Caliper Life Sciences, Inc. (the "Registrant") with the
  Commission are incorporated by reference into this Registration Statement:
  (a)
  The Registrant's Annual Report on Form 10-K for the fiscal year ended December
  31, 2004, filed on March 16, 2005 and amended on April 29, 2005.
  (b)
  The Registrant's Quarterly Reports on Form 10-Q for the quarters ended March
  31, 2005, June 30, 2005 and September 30, 2005 and Current Reports on Form 8-K filed
  February 23, 2005, March 16, 2005, April 26, 2005, April 28, 2005, September 12, 2005,
  September 28, 2005, October 5, 2005 and October 21, 2005.
  (c)
  The description of the Registrant's Common Stock which is contained in the
  Registration Statement on Form 8-A, filed November 22, 1999, under the Securities
  Exchange Act of 1934, as amended (the "Exchange Act"), including any amendment or
  report filed for the purpose of updating such description.
  All reports and other documents subsequently filed by the Registrant pursuant to Sections
  13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment
  which indicates that all securities offered have been sold or which deregisters all securities then
  remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this
  Registration Statement from the date of the filing of such reports and documents.
  ITEM 4. DESCRIPTION OF SECURITIES
  The Preferred Share Purchase Rights (the "Rights") are not currently registered under the
  Exchange Act. Each share of Common Stock issued or outstanding has attached to it a Right. Each
  Right entitles the registered
  Table of Contents
  holder to purchase from Caliper one one-hundredth of a share of
  Series A Junior Participating Preferred Stock, par value $0.001 per share (the "Preferred Shares"),
  at a price of $100.00 per one one-hundredth of a Preferred Share (the "Purchase Price"), subject to
  adjustment. Each one one-hundredth of a share of Preferred Shares has designations and powers,
  preferences and rights, and the qualifications, limitations and restrictions which make its value
  approximately equal to the value of a Common Share.
  The Rights are currently evidenced by the stock certificates representing the Common Shares
  outstanding, and no separate Right Certificates, as defined, have been distributed. Until the
  earlier to occur of (i) subject to limited exceptions, the date of a public announcement that a
  person, entity or group of affiliated or associated persons have acquired beneficial ownership of
  15% or more of the outstanding Common Shares (an "Acquiring Person") or (ii) 10 business days (or
  such later date as may be determined by action of the Board of Directors prior to such time as any
  person or entity becomes an Acquiring Person) following the commencement of, or announcement of an
  intention to commence, a tender offer or exchange offer the consummation of which would result in
  any person or entity becoming an Acquiring Person (the earlier of such dates being called the
  "Distribution Date"), the Rights will be evidenced, with respect to any of the Common Share
  certificates, by such Common Share certificate.
  Until the Distribution Date, the Rights will be transferable with and only with the Common
  Shares. As soon as practicable following the Distribution Date, separate certificates evidencing
  the Rights ("Right Certificates") will be mailed to holders of record of the Common Shares as of
  the close of business on the Distribution Date and such separate Right Certificates alone will
  evidence the Rights.
  The Rights are not exercisable until the Distribution Date. The Rights will expire on December
  17, 2011 (the "Final Expiration Date"), unless the Rights are earlier redeemed or exchanged by
  Caliper, in each case, as described below. The Rights are protected by customary anti-dilution
  provisions to protect the value of the Rights in the event of a stock dividend on, or a
  subdivision, combination or reclassification of, the Preferred Shares or the Common Stock, and in
  certain other events.
  Preferred Shares purchasable upon exercise of the Rights will not be redeemable. Each
  Preferred Share will be entitled to a minimum preferential quarterly dividend payment of $1.00 but
  will be entitled to an aggregate dividend of 100 times the dividend declared per Common Share. In
  the event of liquidation, the holders of the Preferred Shares would be entitled to a minimum
  preferential liquidation payment of $100 per share, but would be entitled to receive an aggregate
  payment equal to 100 times the payment made per Common Share. Each Preferred Share will have 100
  votes, voting together with the Common Shares. Finally, in the event of any merger, consolidation
  or other transaction in which Common Shares are exchanged, each Preferred Share will be entitled to
  receive 100 times the amount of consideration received per Common Share. These rights are protected
  by customary anti-dilution provisions. Because of the nature of the Preferred Shares' dividend and
  liquidation rights, the value of one one-hundredth of a Preferred Share should approximate the
  value of one Common Share. The Preferred Shares would rank junior to any other series of Caliper's
  preferred stock.
  In the event that any person or group of affiliated or associated persons becomes an Acquiring
  Person, proper provision shall be made so that each holder of a Right, other than Rights
  beneficially owned by the Acquiring Person and its associates and affiliates (which will thereafter
  be void), will for a 60-day period have the right to receive upon exercise that number of Common
  Shares having a market value of two times the exercise price of the Right (or, if such number of
  shares is not and cannot be authorized, Caliper may issue Preferred Shares, cash, debt, stock or a
  combination thereof in exchange for the Rights). This right will terminate 60 days after the date
  on which the Rights become nonredeemable (as described below), unless there is an injunction or
  similar obstacle to exercise of the Rights, in which event this right will terminate 60 days after
  the date on which the Rights again become exercisable.
  In the event that Caliper is acquired in a merger or other business combination transaction or
  50% or more of its consolidated assets or earning power are sold to an Acquiring Person, its
  associates or affiliates or certain other persons in which such persons have an interest, proper
  provision will be made so that each holder of a Right will thereafter have the right to receive,
  upon the exercise thereof at the then current exercise price of the Right, that number of shares of
  common stock of the acquiring company which at the time of such transaction will have a market
  value of two times the exercise price of the Right.
  Table of Contents
  At any time after an Acquiring Person becomes an Acquiring Person and prior to the acquisition
  by such Acquiring Person of 50% or more of the outstanding Common Shares, the Board of Directors of
  Caliper may exchange the Rights (other than Rights owned by such person or group which have become
  void), in whole or in part, at an exchange ratio of one Common Share, or one one-hundredth of a
  Preferred Share, per Right (or, at the election of Caliper, Caliper may issue cash, debt, stock or
  a combination thereof in exchange for the Rights), subject to adjustment.
  At any time prior to the earliest of (i) the day of the first public announcement that a
  person has become an Acquiring Person or (ii) the Final Expiration Date, the Board of Directors of
  Caliper may redeem the Rights in whole, but not in part, at a price of $0.01 per Right (the
  "Redemption Price"). Following the expiration of the above periods, the Rights become
  nonredeemable. Immediately upon any redemption of the Rights, the right to exercise the Rights will
  terminate and the only right of the holders of Rights will be to receive the Redemption Price.
  The terms of the Rights may be amended by the Board of Directors of Caliper without the
  consent of the holders of the Rights, except that from and after such time as the rights are
  distributed no such amendment may adversely affect the interest of the holders of the Rights
  excluding the interests of an Acquiring Person.
  Until a Right is exercised, the holder thereof, as such, will have no rights as a stockholder
  of Caliper, including, without limitation, the right to vote or to receive dividends.
  The Rights have certain anti-takeover effects. The Rights will cause substantial dilution to a
  person or group that attempts to acquire Caliper on terms not approved by Caliper's Board of
  Directors. The Rights should not interfere with any merger or other business combination approved
  by the Board of Directors since the Rights may be amended to permit such acquisition or redeemed by
  Caliper at $0.01 per Right prior to the earliest of (i) the time that a person or group has
  acquired beneficial ownership of 15% or more of the Common Shares or (ii) the final expiration date
  of the rights.
  Table of Contents
  ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL
  The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. of Boston, Massachusetts.
  ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS
  Incorporated herein by reference from Part II, Item 15 of the Registrant's Registration
  Statement on Form S-3 (File No. 333-129192) filed with the Commission on October 21, 2005.
  ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED
  Not applicable.
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  ITEM 8. EXHIBITS
  Exhibit
  Number
  Description
  5.1
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  23.1
  Consent of Ernst & Young LLP, independent registered public accounting firm.
  23.2
  Consent of Mintz Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  Reference is made to Exhibit 5.1
  .
  24.1
  Power of Attorney. Reference is made to Signature Page.
  99.3(1)
  1999 Employee Stock Purchase Plan.
  (1)
  Previously filed as the like-numbered Exhibit to the Registration Statement on Form S-8 (No.
  333-95007), and incorporated herein by reference.
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  ITEM 9. UNDERTAKINGS
  A.
  The undersigned Registrant hereby undertakes:
  (1)
  To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:
  (i)
  To include any prospectus required by Section 10(a)(3) of the
  Securities Act;
  (ii)
  To reflect in the prospectus any facts or events arising after
  the effective date of the Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate,
  represent a fundamental change in the information set forth in the Registration
  Statement. Notwithstanding the foregoing, any increase or decrease in volume
  of securities offered (if the total dollar value of securities offered would
  not exceed that which was registered) and any deviation from the low or high
  end of the estimated maximum offering range may be reflected in the form of
  prospectus filed with the Commission pursuant to Rule 424(b) if, in the
  aggregate, the changes in volume and price represent no more than a 20% change
  in the maximum aggregate offering price set forth in the "Calculation of
  Registration Fee" table in the effective Registration Statement.
  (iii)
  To include any material information with respect to the plan
  of distribution not previously disclosed in the Registration Statement or any
  material change to such information in the Registration Statement;
  Provided, however,
  that paragraphs A(1)(i) and A(1)(ii) do not apply if the information
  required to be included in a post-effective amendment by those paragraphs is contained in periodic
  reports filed by the issuer pursuant to Section 13 or Section 15(d) of the Exchange Act that are
  incorporated by reference herein.
  (2)
  That, for the purpose of determining any liability under the Securities Act,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that
  time shall be deemed to be the initial
  bona fide
  offering thereof.
  (3)
  To remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the offering.
  B. The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a)
  or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit
  plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by
  reference in the Registration Statement shall be deemed to be a new registration statement relating
  to the securities offered therein, and the offering of such securities at that time shall be deemed
  to be the initial
  bona fide
  offering thereof.
  C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to
  directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions,
  or otherwise, the Registrant has been advised that in the opinion of the Commission such
  indemnification is against public policy as expressed in the Securities Act and is, therefore,
  unenforceable. In the event that a claim for indemnification against such liabilities (other than
  the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
  person of the Registrant in the successful defense of any action, suit or proceeding) is asserted
  by such director, officer or controlling person in connection with the securities being registered,
  the Registrant will, unless in the opinion of its counsel the matter has been settled by
  controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities Act and will be
  governed by the final adjudication of such issue.
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  SIGNATURES
  Pursuant to the requirements of the Securities Act, the Registrant certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in the Town of Hopkinton, Commonwealth of Massachusetts, on November 21, 2005.
  Caliper Life Sciences, Inc.
  By: /s/ E. Kevin Hrusovsky
  E. Kevin Hrusovsky
  President and Chief Executive Officer
  POWER OF ATTORNEY
  KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
  and appoints E. Kevin Hrusovsky, Thomas T. Higgins, Peter F. McAree and Stephen E. Creager, and
  each or any one of them, his true and lawful attorney-in-fact and agent, with full power of
  substitution and resubstitution, for him and in his name, place and stead, in any and all
  capacities, to sign any and all amendments (including post-effective amendments) to this
  Registration Statement, and to file the same, with all exhibits thereto, and other documents in
  connection therewith, with the Commission, granting unto said attorneys-in-fact and agents, and
  each of them, full power and authority to do and perform each and every act and thing requisite and
  necessary to be done in connection therewith, as fully to all intents and purposes as he might or
  could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or
  any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by
  virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
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  Signature
  Title
  Date
  /s/ E. Kevin Hrusovsky
  President and Chief Executive Officer and Director
  E. Kevin Hrusovsky
  (
  Principal Executive Officer
  )
  November 21,
  2005
  /s/ Thomas T. Higgins
  Executive Vice President and Chief Financial Officer
  Thomas T. Higgins
  (
  Principal Financial Officer
  )
  November 21,
  2005
  /s/ Peter F. McAree
  Vice President, Finance
  Peter F. McAree
  (
  Principal Accounting Officer
  )
  November 21,
  2005
  /s/ Daniel L. Kisner, M.D.
  Daniel L. Kisner, M.D.
  Chairman of the Board of Directors
  November 21,
  2005
  /s/ David V. Milligan, Ph.D.
  David V.
  Milligan, Ph.D.
  Vice Chairman of the Board of Directors
  November 21,
  2005
  /s/ Van Billet
  Van Billet
  Director
  November 21,
  2005
  /s/ Robert C. Bishop, Ph.D.
  Robert C.
  Bishop, Ph.D.
  Director
  November 21,
  2005
  /s/ Allan L. Comstock
  Allan L.Comstock
  Director
  November 21,
  2005
  /s/ Kathryn Tunstall
  Kathryn Tunstall
  Director
  November 21,
  2005
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  EXHIBIT INDEX
  Exhibit
  Number
  Description
  5.1
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  23.1
  Consent of Ernst & Young LLP, independent registered public accounting firm.
  23.2
  Consent of Mintz Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  Reference is made to Exhibit 5.1
  .
  24.1
  Power of Attorney. Reference is made to Signature Page.
  99.3(1)
  1999 Employee Stock Purchase Plan.
  (1)
  Previously filed as the like-numbered Exhibit to the Registration Statement on Form S-8 (No.
  333-95007), and incorporated herein by reference.