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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 10pt">As
  filed with the Securities and Exchange Commission on May&nbsp;24, 2006
  </DIV>
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 8pt">REGISTRATION
  NO. 333 - &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT<BR>
  under the<BR>
  SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="100%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="100%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 24pt" valign="bottom">
      <TD nowrap align="center"><B>ALTUS PHARMACEUTICALS INC.</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top">(<I>Exact Name of Registrant as Specified in Its Charter)</I></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 10pt" valign="bottom">
      <TD nowrap align="center"><B>Delaware</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>04-35732779</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top">(<I>State or Other Jurisdiction<BR>
  of Incorporation or Organization</I>)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(<I>I.R.S. Employer<BR>
  Identification No.</I>)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>125 Sidney Street<BR>
  Cambridge, MA 02139</B><BR>
  (<I>Address, Including Zip Code, of Principal Executive Offices</I>)
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Altus Pharmaceuticals Inc. 1993 Stock Option Plan<BR>
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan</B><BR>
  <I>(Full Titles of the Plans)</I>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Sheldon Berkle<BR>
  President and Chief Executive Officer<BR>
  Altus Pharmaceuticals Inc.<BR>
  125 Sidney Street<BR>
  Cambridge, MA 02139</B><BR>
  (<I>Name, Address and Telephone Number, Including Area Code, of Agent For Service</I>)
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 15pt">with copies to:
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Jonathan L. Kravetz, Esq.<BR>
  Megan N. Gates, Esq<BR>
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.<BR>
  One Financial Center<BR>
  Boston, Massachusetts 02111</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 10pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>CALCULATION OF REGISTRATION FEE</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="28%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed maximum</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed maximum</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="right" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount to be</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">offering price</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">aggregate offering </TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="left">Title of securities to be registered</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">registered<SUP style="font-size: 85%; vertical-align: text-top">(1)(2)</SUP></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">per share<SUP style="font-size: 85%; vertical-align: text-top">(3)</SUP></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">price<SUP style="font-size: 85%; vertical-align: text-top">(3)</SUP></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">registration fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom" style="background: #cceeff">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, $.01 par value</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">3,559,330</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">6.34</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">22,566,152.20</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">2,414.58</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">986,255</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">19.13</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">18,867,058.15</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">2,018.78</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="background: #cceeff">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">4,545,585</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">4,433.36</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Pursuant to Rule&nbsp;416 under the Securities Act of 1933, as amended (the &#147;Securities Act&#148;),
  this registration statement shall also cover any additional shares of common stock which
  become issuable under the above-named plans by reason of any stock dividend, stock split,
  recapitalization or any other similar transaction effected without the receipt of
  consideration which results in an increase in the number of our outstanding shares of common
  stock.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The number of shares of common stock, par value $0.01 per share (&#147;Common Stock&#148;), stated
  above consists of the aggregate number of shares which may be sold (i)&nbsp;upon the exercise of
  options which have been granted under the Altus Pharmaceuticals Inc. 1993 Stock Option Plan
  (the &#147;1993 Plan&#148;) and (ii)&nbsp;upon the exercise of options which have been granted and/or may
  hereafter be granted and the issuance of stock awards which may hereafter be granted under the
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan (the &#147;2002 Plan&#148;).</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>This estimate is calculated solely for the purpose of determining the registration fee
  pursuant to the provisions of Rule 457(c) and (h)&nbsp;under the Securities Act as follows: (i)&nbsp;in
  the case of shares of Common Stock which may be purchased upon exercise of outstanding
  options, the fee is calculated on the basis of the price at which the options may be
  exercised; and (ii)&nbsp;in the case of shares of Common Stock for which options and stock awards
  have not yet been granted and the exercise or purchase price of which is therefore unknown,
  the fee is calculated on the basis of the average of the high and low sale prices per share of
  the Common Stock on the Nasdaq National Market as of a date (May&nbsp;18, 2006) within five
  business days prior to filing this Registration Statement.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART I &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;1. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Plan Information.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;2. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Registrant Information and Employee Plan Annual Information.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003">PART II &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;3. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporation of Documents by Reference.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;4. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Description of Securities.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;5. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Interests of Named Experts and Counsel.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;6. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Indemnification of Directors and Officers.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#008">Item&nbsp;7. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exemption from Registration Claimed.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#009">Item&nbsp;8. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#010">Item&nbsp;9. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Undertakings.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#011">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#012">EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b61037apexv5.htm">EX-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo P.C.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b61037apexv23w2.htm">EX-23.2 Consent of Deloitte & Touche LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <!-- link1 "PART I &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS " -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
  </DIV>
  
  <!-- link2 "Item&nbsp;1. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Plan Information." -->
  <DIV align="left"><A NAME="001"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Item&nbsp;1.
  &nbsp;&nbsp; Plan Information</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The information required by Item&nbsp;1 is included in documents sent or given by the Registrant to
  participants in the plans covered by this registration statement pursuant to Rule&nbsp;428(b)(1) under
  the Securities Act of 1933, as amended (the &#147;Securities Act&#148;).
  </DIV>
  <!-- link2 "Item&nbsp;2. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Registrant Information and Employee Plan Annual Information." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Item&nbsp;2.
  &nbsp;&nbsp; Registrant Information and Employee Plan Annual Information</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The written statement required by Item&nbsp;2 is included in documents sent or given by the
  Registrant to participants in the plans covered by this registration statement pursuant to Rule
  428(b)(1) under the Securities Act.
  </DIV>
  
  <P align="center" style="font-size: 10pt">
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "PART II &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  </DIV>
  
  <!-- link2 "Item&nbsp;3. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporation of Documents by Reference." -->
  <DIV align="left"><A NAME="004"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Item&nbsp;3.
  &nbsp;&nbsp; Incorporation of Documents by Reference</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Securities and Exchange Commission
  (the &#147;Commission&#148;) are incorporated herein by reference:
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Registrant&#146;s Common Stock contained in the Registrant&#146;s Registration
  Statement on Form 8-A, filed with the Commission on January&nbsp;11, 2006 (File No.&nbsp;000-51711),
  including any amendment or report filed for the purpose of updating such description;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31, 2005, as
  amended (File No.&nbsp;000-51711);</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K filed on February&nbsp;15, 2006 (File No.&nbsp;000-51711);</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(4)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K filed on March&nbsp;29, 2006 (File No.&nbsp;000-51711); and</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(5)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Quarterly Report on Form 10-Q for the quarter ended March&nbsp;31, 2006 (File No.
  000-51711);</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective
  amendment which indicates that all securities offered hereby have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such reports and documents.
  </DIV>
  <!-- link2 "Item&nbsp;4. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Description of Securities." -->
  <DIV align="left"><A NAME="005"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Item&nbsp;4.
  &nbsp;&nbsp; Description of Securities</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;5. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Interests of Named Experts and Counsel." -->
  <DIV align="left"><A NAME="006"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Item&nbsp;5.
  &nbsp;&nbsp; Interests of Named Experts and Counsel</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm, their families
  and trusts for their benefit own an aggregate of 12,794 shares of Common Stock of the Registrant
  and options and warrants to purchase 1,000 shares of Common Stock of the Registrant.
  </DIV>
  <!-- link2 "Item&nbsp;6. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Indemnification of Directors and Officers." -->
  <DIV align="left"><A NAME="007"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Item&nbsp;6.
  &nbsp;&nbsp; Indemnification of Directors and Officers</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant&#146;s restated certificate of incorporation and restated bylaws provide that each
  person who was or is made a party or is threatened to be made a party to any action, suit or
  proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he
  or she is or was one of the Registrant&#146;s directors or officers or is or was serving at its request
  as a director, officer, employee or agent of another corporation, or of a partnership, joint
  venture, trust or other enterprise, shall be indemnified by the Registrant to the fullest extent
  authorized by the Delaware General Corporation Law against all expense, liability and loss
  (including attorneys&#146; fees, judgments, fines or penalties and amounts paid in
  </DIV>
  
  <P align="center" style="font-size: 10pt">II-1
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">settlement)
  reasonably incurred in connection with legal proceedings. A director or officer will not receive
  indemnification if he or she is found not to have acted in good faith and in a manner he or she
  reasonably believed to be in, or not opposed to, the Registrant&#146;s best interest.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the Delaware General Corporation Law permits a corporation to indemnify any
  director or officer of the corporation against expenses, including attorney&#146;s fees, judgments,
  fines and amounts paid in settlement actually and reasonably incurred in connection with any
  action, suit or proceeding brought by reason of the fact that such person is or was a director or
  officer of the corporation, if such person acted in good faith and in a manner that he reasonably
  believed to be in, or not opposed to, the best interests of the corporation, and, with respect to
  any criminal action or proceeding, if he or she had no reason to believe his or her conduct was
  unlawful. In a derivative action, <I>i.e</I>., one brought by or on behalf of the corporation,
  indemnification may be provided only for expenses actually and reasonably incurred by any director
  or officer in connection with the defense or settlement of such an action or suit if such person
  acted in good faith and in a manner that he or she reasonably believed to be in, or not opposed to,
  the best interests of the corporation, except that no indemnification shall be provided if such
  person shall have been adjudged to be liable to the corporation, unless and only to the extent that
  the court in which the action or suit was brought shall determine that the defendant is fairly and
  reasonably entitled to indemnity for such expenses despite such adjudication of liability.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to Section&nbsp;102(b)(7) of the Delaware General Corporation Law, Article&nbsp;NINTH of the
  Registrant&#146;s restated certificate of incorporation eliminates the liability of a director to the
  Registrant or its stockholders for monetary damages for such a breach of fiduciary duty as a
  director, except for liabilities arising:
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>from any breach of the director&#146;s duty of loyalty to the Registrant or its stockholders;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>from acts or omissions not in good faith or which involve intentional
  misconduct or a knowing violation of law;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>under Section&nbsp;174 of the Delaware General Corporation Law; and</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(4)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>from any transaction from which the director derived an improper personal benefit.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">The Registrant carries insurance policies insuring its directors and officers against certain
  liabilities that they may incur in their capacity as directors and officers. In addition, the
  Registrant has entered into indemnification agreements with each of its directors and officers,
  with respect to the Registrant&#146;s obligation to indemnify those persons under certain circumstances
  as described in the agreements.
  </DIV>
  <!-- link2 "Item&nbsp;7. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exemption from Registration Claimed." -->
  <DIV align="left"><A NAME="008"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Item&nbsp;7.
  &nbsp;&nbsp; Exemption from Registration Claimed</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;8. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits." -->
  <DIV align="left"><A NAME="009"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Item&nbsp;8.
  &nbsp;&nbsp; Exhibits</U>.
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="6%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="92%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant. Filed as Exhibit&nbsp;3.2 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Bylaws of the Registrant. Filed as Exhibit&nbsp;3.4 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">II-2
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="6%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="92%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Certificate. Filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered. Filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche
  LLP, Independent Registered Public Accounting Firm.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(24)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney to file future amendments (set forth on the signature page of this
  Registration Statement).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Altus Pharmaceuticals Inc. 1993 Stock Option Plan. Filed as Exhibit&nbsp;10.1 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan. Filed as Exhibit&nbsp;10.4 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as
  amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <!-- link2 "Item&nbsp;9. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Undertakings." -->
  <DIV align="left"><A NAME="010"></A></DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Item&nbsp;9.
  &nbsp;&nbsp; Undertakings</U>.
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes:</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="7%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(i)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To include any prospectus required by Section&nbsp;10(a)(3) of
  the Securities Act of 1933;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="6%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(ii)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To reflect in the prospectus any facts or events arising
  after the effective date of the Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate,
  represent a fundamental change in the information set forth in the
  Registration Statement. Notwithstanding the foregoing, any increase or
  decrease in volume of securities offered (if the total dollar value of
  securities offered would not exceed that which was registered) and any
  deviation from the low or high end of the estimated maximum offering range
  may be reflected in the form of prospectus filed with the Commission pursuant
  to Rule 424(b) if, in the aggregate, the changes in volume and price
  represent no more than a 20% change in the maximum aggregate offering price
  set forth in the &#147;Calculation of Registration Fee&#148; table in the effective
  Registration Statement.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="6%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(iii)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To include any material information with respect to the plan
  of distribution not previously disclosed in the Registration Statement or any
  material change to such information in the Registration Statement;</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  information required to be included in a post-effective amendment by those paragraphs is
  contained in periodic reports filed with or furnished to the Commission by the Registrant
  pursuant to Section&nbsp;13 or</TD>
  </TR>
  
  
  </TABLE>
  </DIV>
  <P align="center" style="font-size: 10pt">II-3
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Section&nbsp;15(d) of the Securities Exchange Act of 1934 that are
  incorporated by reference in this Registration Statement.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="2%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>That, for the purpose of determining any liability under the Securities Act of
  1933, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such
  securities at that time shall be deemed to be the initial bona fide offering thereof.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="2%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the offering.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant&#146;s annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by
  reference in this Registration Statement shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed
  in the Act and is, therefore, unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense
  of any action, suit or proceeding) is asserted by such director, officer or controlling person
  in connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <P align="center" style="font-size: 10pt">II-4
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  
  </TABLE>
  </DIV>
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="011"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Cambridge, Massachusetts on May&nbsp;23, 2006.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left"><FONT style="font-variant: SMALL-CAPS"><B>ALTUS PHARMACEUTICALS INC.</B></FONT><BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Sheldon Berkle
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Sheldon Berkle&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">President and Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">POWER OF ATTORNEY
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Sheldon Berkle, Jonathan I.
  Lieber and Jonathan L. Kravetz, and each of them singly, his/her true and lawful attorneys-in-fact
  and agents, with full power of substitution and resubstitution in each of them singly, for him/her
  and in his/her name, place and stead, and in any and all capacities, to sign any and all amendments
  (including post-effective amendments) to this Registration Statement on Form S-8 of Altus
  Pharmaceuticals Inc., and to file the same, with all exhibits thereto and other documents in
  connection therewith, with the Securities and Exchange Commission, granting to the
  attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and
  every act and thing requisite or necessary to be done in or about the premises, as full to all
  intents and purposes as he might or could do in person, hereby ratifying and confirming all that
  the attorneys-in-fact and agents or any of each of them or their substitute may lawfully do or
  cause to be done by virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="35%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="14%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 10pt" valign="bottom">
      <TD nowrap align="left"><B><u>Signature</u></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><u>Title</u></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><u>Date</u></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Sheldon Berkle
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Sheldon Berkle</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  President, Chief Executive Officer and Director<BR>
  (principal executive officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Jonathan I. Lieber
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Jonathan I. Lieber</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Vice President, Chief
  Financial Officer and Treasurer
  (principal financial and
  accounting officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ John P. Richard
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  John P. Richard</TD>
      <TD>&nbsp;</TD>
      <TD valign="top" align="left">
  Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">II-5
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="35%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="14%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 10pt" valign="bottom">
      <TD nowrap align="left"><B>&nbsp;</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B>&nbsp;</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B>&nbsp;</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="top" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Richard H. Aldrich
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Richard H. Aldrich</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="top" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Lynne H. Brum
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Lynne H. Brum</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="top" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Stewart Hen
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Stewart Hen</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="top" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Peter L. Lanciano
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Peter L. Lanciano</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="top" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Jonathan S. Leff
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Jonathan S. Leff</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="top" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Manuel A. Navia
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Manuel A. Navia, Ph.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Harry H. Penner
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Harry H. Penner, Jr.</TD>
      <TD>&nbsp;</TD>
      <TD valign="top" align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Jonathan D. Root
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Jonathan D. Root, M.D.</TD>
      <TD>&nbsp;</TD>
      <TD valign="top" align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="top" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Michael S. Wyzga
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Michael S. Wyzga</TD>
      <TD>&nbsp;</TD>
      <TD valign="top" align="left">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">May 23, 2006</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">II-6
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "EXHIBITS" -->
  <DIV align="left"><A NAME="012"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>ALTUS PHARMACEUTICALS INC.</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX TO EXHIBITS FILED WITH<BR>
  FORM S-8 REGISTRATION STATEMENT</B><BR>
  &nbsp;
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="90%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 10pt" valign="bottom">
      <TD nowrap align="left">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 10pt" valign="bottom">
      <TD nowrap align="left"><U>Number</U></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><U>Description</U></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant. Filed as Exhibit&nbsp;3.2 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Bylaws of the Registrant. Filed as Exhibit&nbsp;3.4 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Certificate. Filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered. Filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche
  LLP, Independent Registered Public Accounting Firm.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(24)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney to file future amendments (set forth on the signature page of this
  Registration Statement).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Altus Pharmaceuticals Inc. 1993 Stock Option Plan. Filed as Exhibit&nbsp;10.1 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan. Filed as Exhibit&nbsp;10.4 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as
  amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">II-7
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  As
  filed with the Securities and Exchange Commission on May 24, 2006
  REGISTRATION
  NO. 333 -
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  under the
  SECURITIES ACT OF 1933
  ALTUS PHARMACEUTICALS INC.
  (
  Exact Name of Registrant as Specified in Its Charter)
  Delaware
  04-35732779
  (
  State or Other Jurisdiction
  of Incorporation or Organization
  )
  (
  I.R.S. Employer
  Identification No.
  )
  125 Sidney Street
  Cambridge, MA 02139
  (
  Address, Including Zip Code, of Principal Executive Offices
  )
  Altus Pharmaceuticals Inc. 1993 Stock Option Plan
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan
  (Full Titles of the Plans)
  Sheldon Berkle
  President and Chief Executive Officer
  Altus Pharmaceuticals Inc.
  125 Sidney Street
  Cambridge, MA 02139
  (
  Name, Address and Telephone Number, Including Area Code, of Agent For Service
  )
  with copies to:
  Jonathan L. Kravetz, Esq.
  Megan N. Gates, Esq
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  One Financial Center
  Boston, Massachusetts 02111
  CALCULATION OF REGISTRATION FEE
  Proposed maximum
  Proposed maximum
  Amount to be
  offering price
  aggregate offering
  Amount of
  Title of securities to be registered
  registered
  (1)(2)
  per share
  (3)
  price
  (3)
  registration fee
  Common Stock, $.01 par value
  3,559,330
  $
  6.34
  $
  22,566,152.20
  $
  2,414.58
  986,255
  $
  19.13
  $
  18,867,058.15
  $
  2,018.78
  4,545,585
  $
  4,433.36
  (1)
  Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"),
  this registration statement shall also cover any additional shares of common stock which
  become issuable under the above-named plans by reason of any stock dividend, stock split,
  recapitalization or any other similar transaction effected without the receipt of
  consideration which results in an increase in the number of our outstanding shares of common
  stock.
  (2)
  The number of shares of common stock, par value $0.01 per share ("Common Stock"), stated
  above consists of the aggregate number of shares which may be sold (i) upon the exercise of
  options which have been granted under the Altus Pharmaceuticals Inc. 1993 Stock Option Plan
  (the "1993 Plan") and (ii) upon the exercise of options which have been granted and/or may
  hereafter be granted and the issuance of stock awards which may hereafter be granted under the
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan (the "2002 Plan").
  (3)
  This estimate is calculated solely for the purpose of determining the registration fee
  pursuant to the provisions of Rule 457(c) and (h) under the Securities Act as follows: (i) in
  the case of shares of Common Stock which may be purchased upon exercise of outstanding
  options, the fee is calculated on the basis of the price at which the options may be
  exercised; and (ii) in the case of shares of Common Stock for which options and stock awards
  have not yet been granted and the exercise or purchase price of which is therefore unknown,
  the fee is calculated on the basis of the average of the high and low sale prices per share of
  the Common Stock on the Nasdaq National Market as of a date (May 18, 2006) within five
  business days prior to filing this Registration Statement.
  TABLE OF CONTENTS
  PART I      INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  Item 1.      Plan Information.
  Item 2.      Registrant Information and Employee Plan Annual Information.
  PART II      INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.      Incorporation of Documents by Reference.
  Item 4.      Description of Securities.
  Item 5.      Interests of Named Experts and Counsel.
  Item 6.      Indemnification of Directors and Officers.
  Item 7.      Exemption from Registration Claimed.
  Item 8.      Exhibits.
  Item 9.      Undertakings.
  SIGNATURES
  EXHIBITS
  EX-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo P.C.
  EX-23.2 Consent of Deloitte & Touche LLP
  Table of Contents
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  Item 1.
     Plan Information
  .
  The information required by Item 1 is included in documents sent or given by the Registrant to
  participants in the plans covered by this registration statement pursuant to Rule 428(b)(1) under
  the Securities Act of 1933, as amended (the "Securities Act").
  Item 2.
     Registrant Information and Employee Plan Annual Information
  .
  The written statement required by Item 2 is included in documents sent or given by the
  Registrant to participants in the plans covered by this registration statement pursuant to Rule
  428(b)(1) under the Securities Act.
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
     Incorporation of Documents by Reference
  .
  The following documents filed by the Registrant with the Securities and Exchange Commission
  (the "Commission") are incorporated herein by reference:
  (1)
  The description of the Registrant's Common Stock contained in the Registrant's Registration
  Statement on Form 8-A, filed with the Commission on January 11, 2006 (File No. 000-51711),
  including any amendment or report filed for the purpose of updating such description;
  (2)
  The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2005, as
  amended (File No. 000-51711);
  (3)
  The Registrant's Current Report on Form 8-K filed on February 15, 2006 (File No. 000-51711);
  (4)
  The Registrant's Current Report on Form 8-K filed on March 29, 2006 (File No. 000-51711); and
  (5)
  The Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2006 (File No.
  000-51711);
  All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective
  amendment which indicates that all securities offered hereby have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such reports and documents.
  Item 4.
     Description of Securities
  .
  Not applicable.
  Item 5.
     Interests of Named Experts and Counsel
  .
  The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm, their families
  and trusts for their benefit own an aggregate of 12,794 shares of Common Stock of the Registrant
  and options and warrants to purchase 1,000 shares of Common Stock of the Registrant.
  Item 6.
     Indemnification of Directors and Officers
  .
  The Registrant's restated certificate of incorporation and restated bylaws provide that each
  person who was or is made a party or is threatened to be made a party to any action, suit or
  proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he
  or she is or was one of the Registrant's directors or officers or is or was serving at its request
  as a director, officer, employee or agent of another corporation, or of a partnership, joint
  venture, trust or other enterprise, shall be indemnified by the Registrant to the fullest extent
  authorized by the Delaware General Corporation Law against all expense, liability and loss
  (including attorneys' fees, judgments, fines or penalties and amounts paid in
  II-1
  Table of Contents
  settlement)
  reasonably incurred in connection with legal proceedings. A director or officer will not receive
  indemnification if he or she is found not to have acted in good faith and in a manner he or she
  reasonably believed to be in, or not opposed to, the Registrant's best interest.
  Section 145 of the Delaware General Corporation Law permits a corporation to indemnify any
  director or officer of the corporation against expenses, including attorney's fees, judgments,
  fines and amounts paid in settlement actually and reasonably incurred in connection with any
  action, suit or proceeding brought by reason of the fact that such person is or was a director or
  officer of the corporation, if such person acted in good faith and in a manner that he reasonably
  believed to be in, or not opposed to, the best interests of the corporation, and, with respect to
  any criminal action or proceeding, if he or she had no reason to believe his or her conduct was
  unlawful. In a derivative action,
  i.e
  ., one brought by or on behalf of the corporation,
  indemnification may be provided only for expenses actually and reasonably incurred by any director
  or officer in connection with the defense or settlement of such an action or suit if such person
  acted in good faith and in a manner that he or she reasonably believed to be in, or not opposed to,
  the best interests of the corporation, except that no indemnification shall be provided if such
  person shall have been adjudged to be liable to the corporation, unless and only to the extent that
  the court in which the action or suit was brought shall determine that the defendant is fairly and
  reasonably entitled to indemnity for such expenses despite such adjudication of liability.
  Pursuant to Section 102(b)(7) of the Delaware General Corporation Law, Article NINTH of the
  Registrant's restated certificate of incorporation eliminates the liability of a director to the
  Registrant or its stockholders for monetary damages for such a breach of fiduciary duty as a
  director, except for liabilities arising:
  (1)
  from any breach of the director's duty of loyalty to the Registrant or its stockholders;
  (2)
  from acts or omissions not in good faith or which involve intentional
  misconduct or a knowing violation of law;
  (3)
  under Section 174 of the Delaware General Corporation Law; and
  (4)
  from any transaction from which the director derived an improper personal benefit.
  The Registrant carries insurance policies insuring its directors and officers against certain
  liabilities that they may incur in their capacity as directors and officers. In addition, the
  Registrant has entered into indemnification agreements with each of its directors and officers,
  with respect to the Registrant's obligation to indemnify those persons under certain circumstances
  as described in the agreements.
  Item 7.
     Exemption from Registration Claimed
  .
  Not applicable.
  Item 8.
     Exhibits
  .
  (4.1)
  Restated Certificate of Incorporation of the Registrant. Filed as Exhibit 3.2 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (4.2)
  Restated Bylaws of the Registrant. Filed as Exhibit 3.4 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  II-2
  Table of Contents
  (4.3)
  Form of Common Stock Certificate. Filed as Exhibit 4.1 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered. Filed herewith.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit 5).
  (23.2)
  Consent of Deloitte & Touche
  LLP, Independent Registered Public Accounting Firm.
  (24)
  Power of Attorney to file future amendments (set forth on the signature page of this
  Registration Statement).
  (99.1)
  Altus Pharmaceuticals Inc. 1993 Stock Option Plan. Filed as Exhibit 10.1 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (99.2)
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan. Filed as Exhibit 10.4 to the Registrant's Registration Statement on Form S-1, as
  amended (File No. 333-129037) and incorporated herein by reference.
  Item 9.
     Undertakings
  .
  (a)
  The undersigned Registrant hereby undertakes:
  (1)
  To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:
  (i)
  To include any prospectus required by Section 10(a)(3) of
  the Securities Act of 1933;
  (ii)
  To reflect in the prospectus any facts or events arising
  after the effective date of the Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the aggregate,
  represent a fundamental change in the information set forth in the
  Registration Statement. Notwithstanding the foregoing, any increase or
  decrease in volume of securities offered (if the total dollar value of
  securities offered would not exceed that which was registered) and any
  deviation from the low or high end of the estimated maximum offering range
  may be reflected in the form of prospectus filed with the Commission pursuant
  to Rule 424(b) if, in the aggregate, the changes in volume and price
  represent no more than a 20% change in the maximum aggregate offering price
  set forth in the "Calculation of Registration Fee" table in the effective
  Registration Statement.
  (iii)
  To include any material information with respect to the plan
  of distribution not previously disclosed in the Registration Statement or any
  material change to such information in the Registration Statement;
  Provided, however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  information required to be included in a post-effective amendment by those paragraphs is
  contained in periodic reports filed with or furnished to the Commission by the Registrant
  pursuant to Section 13 or
  II-3
  Table of Contents
  Section 15(d) of the Securities Exchange Act of 1934 that are
  incorporated by reference in this Registration Statement.
  (2)
  That, for the purpose of determining any liability under the Securities Act of
  1933, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such
  securities at that time shall be deemed to be the initial bona fide offering thereof.
  (3)
  To remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by
  reference in this Registration Statement shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (c)
  Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed
  in the Act and is, therefore, unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense
  of any action, suit or proceeding) is asserted by such director, officer or controlling person
  in connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.
  II-4
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Cambridge, Massachusetts on May 23, 2006.
  ALTUS PHARMACEUTICALS INC.
  By:
  /s/ Sheldon Berkle
  Sheldon Berkle
  President and Chief Executive Officer
  POWER OF ATTORNEY
  Each person whose signature appears below constitutes and appoints Sheldon Berkle, Jonathan I.
  Lieber and Jonathan L. Kravetz, and each of them singly, his/her true and lawful attorneys-in-fact
  and agents, with full power of substitution and resubstitution in each of them singly, for him/her
  and in his/her name, place and stead, and in any and all capacities, to sign any and all amendments
  (including post-effective amendments) to this Registration Statement on Form S-8 of Altus
  Pharmaceuticals Inc., and to file the same, with all exhibits thereto and other documents in
  connection therewith, with the Securities and Exchange Commission, granting to the
  attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and
  every act and thing requisite or necessary to be done in or about the premises, as full to all
  intents and purposes as he might or could do in person, hereby ratifying and confirming all that
  the attorneys-in-fact and agents or any of each of them or their substitute may lawfully do or
  cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Sheldon Berkle
  Sheldon Berkle
  President, Chief Executive Officer and Director
  (principal executive officer)
  May 23, 2006
  /s/ Jonathan I. Lieber
  Jonathan I. Lieber
  Vice President, Chief
  Financial Officer and Treasurer
  (principal financial and
  accounting officer)
  May 23, 2006
  /s/ John P. Richard
  John P. Richard
  Chairman of the Board
  May 23, 2006
  II-5
  Table of Contents
  /s/ Richard H. Aldrich
  Richard H. Aldrich
  Director
  May 23, 2006
  /s/ Lynne H. Brum
  Lynne H. Brum
  Director
  May 23, 2006
  /s/ Stewart Hen
  Stewart Hen
  Director
  May 23, 2006
  /s/ Peter L. Lanciano
  Peter L. Lanciano
  Director
  May 23, 2006
  /s/ Jonathan S. Leff
  Jonathan S. Leff
  Director
  May 23, 2006
  /s/ Manuel A. Navia
  Manuel A. Navia, Ph.D.
  Director
  May 23, 2006
  /s/ Harry H. Penner
  Harry H. Penner, Jr.
  Director
  May 23, 2006
  /s/ Jonathan D. Root
  Jonathan D. Root, M.D.
  Director
  May 23, 2006
  /s/ Michael S. Wyzga
  Michael S. Wyzga
  Director
  May 23, 2006
  II-6
  Table of Contents
  ALTUS PHARMACEUTICALS INC.
  INDEX TO EXHIBITS FILED WITH
  FORM S-8 REGISTRATION STATEMENT
  Exhibit
  Number
  Description
  (4.1)
  Restated Certificate of Incorporation of the Registrant. Filed as Exhibit 3.2 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (4.2)
  Restated Bylaws of the Registrant. Filed as Exhibit 3.4 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.3)
  Form of Common Stock Certificate. Filed as Exhibit 4.1 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered. Filed herewith.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit 5).
  (23.2)
  Consent of Deloitte & Touche
  LLP, Independent Registered Public Accounting Firm.
  (24)
  Power of Attorney to file future amendments (set forth on the signature page of this
  Registration Statement).
  (99.1)
  Altus Pharmaceuticals Inc. 1993 Stock Option Plan. Filed as Exhibit 10.1 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (99.2)
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan. Filed as Exhibit 10.4 to the Registrant's Registration Statement on Form S-1, as
  amended (File No. 333-129037) and incorporated herein by reference.
  II-7