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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">As filed with the Securities and Exchange Commission on July&nbsp;31, 2007</DIV>
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">REGISTRATION NO. 333 &#151;
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT<BR>
  under the<BR>
  SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>AMICAS, Inc.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(<I>Exact Name of Registrant as Specified in Its Charter)</I></DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>59-2248411</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(<I>State or Other Jurisdiction <BR>
  of Incorporation or Organization</I>)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(<I>I.R.S. Employer<BR>
  Identification No.</I>)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>20 Guest Street, Suite&nbsp;400<BR>
  Boston, Massachusetts 02135</B><BR>
  (<I>Address, Including Zip Code, of Principal Executive Offices</I>)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>AMICAS, INC. 2007 EMPLOYEE STOCK PURCHASE PLAN</B><BR>
  <I>(Full Titles of the Plan)</I></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Stephen N. Kahane, M.D., M.S.<BR>
  20 Guest Street, Suite&nbsp;400<BR>
  Boston, Massachusetts 02135</B></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">(<I>Name, Address and Telephone Number, Including<BR>
  Area Code, of Agent For Service</I>)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Copies to:</B></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Darin P. Smith, Esq.<BR>
  Wendy B. Silverman, Esq.<BR>
  Mintz, Levin, Cohn, Ferris, Glovsky<BR>
  and Popeo, P.C.<BR>
  One Financial Center<BR>
  Boston, Massachusetts 02111<BR>
  (617)&nbsp;542-6000</B></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>CALCULATION OF REGISTRATION FEE</B></DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="34%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="21%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of </TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Securities to be </TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Offering Price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Aggregate</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Registration</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Registered</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Registered<SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Per Share<SUP style="font-size: 85%; vertical-align: text-top"> (2)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Offering Price<SUP style="font-size: 85%; vertical-align: text-top"> (2)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock,
  $0.001 par value</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">750,000 shares</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$3.47</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$2,602,500</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$79.90</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Rights to purchase
  Series&nbsp;B Preferred
  Stock</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">(3)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">(3)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">(3)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">None</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
   <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>The number of shares of common stock, par value $0.001 per share (&#147;Common Stock&#148;), stated
  above consists of the aggregate number of shares which may be purchased under the AMICAS, Inc.
  2007 Employee Stock Purchase Plan (the &#147;2007 Stock Plan&#148;). The maximum number of shares which
  may be purchased under the 2007 Stock Plan is subject to adjustment in accordance with certain
  anti-dilution and other provisions of the 2007 Stock Plan. Accordingly, pursuant to Rule&nbsp;416
  under the Securities Act of 1933, as amended (the &#147;Securities Act&#148;), this Registration
  Statement covers, in addition to the number of shares stated above, an indeterminate number of
  shares which may be otherwise issuable after the operation of any such anti-dilution and other
  provisions of the 2007 Stock Plan.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(c) and (h)&nbsp;under the Securities Act, and based upon the average
  of the high and low prices of the Registrant&#146;s Common Stock as reported on the Nasdaq Global
  Market on July&nbsp;27, 2007.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>No separate consideration will be received for the Rights to purchase Series&nbsp;B Preferred
  Stock (the &#147;Rights&#148;).</TD>
  </TR>
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U>EXPLANATORY NOTE</U>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with the instructional Note to Part&nbsp;I of Form S-8 as promulgated by the
  Securities and Exchange Commission (the &#147;Commission&#148;), the information specified by Part&nbsp;I of Form
  S-8 has been omitted from this Registration Statement on Form S-8 for offers to purchase Common
  Stock pursuant to the 2007 Stock Plan.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;4. Description of Securities</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;7. Exemption from Registration Claimed</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;8. Exhibits</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;9. Undertakings</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#008">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#009">EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b66325aiexv5w1.htm">Ex-5.1 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b66325aiexv23w2.htm">Ex-23.2 Consent of BDO Seidman, LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <!-- link1 "PART II" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  </DIV>
  
  
  
  
  <!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;3. Incorporation of Documents by Reference</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">1.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Annual Report on Form 10-K for the year ended December&nbsp;31, 2006, filed
  with the Commission on March&nbsp;16, 2007 (File No.&nbsp;000-25311).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">2.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Quarterly Report on Form 10-Q for the quarterly period ended March&nbsp;31,
  2007, filed with the Commission on May&nbsp;10, 2007 (File No.&nbsp;000-25311).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">3.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K, filed with the Commission on July&nbsp;10, 2007
  (File No.&nbsp;000-25311).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">4.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K, filed with the Commission on June&nbsp;15, 2007
  (File No.&nbsp;000-25311).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">5.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K, filed with the Commission on April&nbsp;30, 2007
  (except with respect to the items reported under Item&nbsp;2.02 of such Form 8-K) (File No.&nbsp;000-
  25311).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">6.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K, filed with the Commission on March&nbsp;1, 2007
  (except with respect to the items reported under Item&nbsp;2.02 of such Form 8-K) (File No.&nbsp;000-
  25311).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">7.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Report on Form 8-K, filed with the Commission on February&nbsp;7,
  2007 (File No.&nbsp;000-25311).</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">8.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Registrant&#146;s Common Stock contained in the Registrant&#146;s
  Registration Statement on Form 8-A (File No.&nbsp;000-25311) filed with the Commission on January
  28, 1999 under the Securities Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;),
  including any amendment or report filed for the purpose of updating such description.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">9.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Registrant&#146;s Common Stock contained in the Registrant&#146;s
  Registration Statement on Form 8-A (File No.&nbsp;000-12799) filed with the Commission on March
  12, 1997 under the Exchange Act, including any amendment or report filed for the purpose of
  updating such description.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">10.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Rights under the Registrant&#146;s Rights Agreement (which are
  currently transferred with the Registrant&#146;s Common Stock) contained in the Registrant&#146;s
  Registration Statement on Form 8-A (File No.&nbsp;000-25311) filed with the Commission on April
  2, 2003 under the Exchange Act, including any amendment or report for the purpose of
  updating such description.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">11.</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Rights under the Registrant&#146;s Rights Agreement (which are
  currently transferred with the Registrant&#146;s Common Stock) contained in the Registrant&#146;s
  Registration Statement on Form 8-A (File No.&nbsp;000-12799) filed with the Commission on January
  3, 2003 under the Exchange Act, including any amendment or report for the purpose of
  updating such description.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
  amendment which indicates that all securities offered hereby have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such reports and documents. Any statement contained in a
  document incorporated or deemed to be incorporated by reference herein shall be deemed
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-1<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">to be modified or superseded for the purposes of this registration statement to the extent that a
  statement contained herein or in any other subsequently filed document which also is or is deemed
  to be incorporated by reference herein modifies or supersedes such statement. Any statement so
  modified or superseded shall not be deemed, except as so modified or superseded, to constitute a
  part of this registration statement.
  </DIV>
  
  <!-- link2 "Item&nbsp;4. Description of Securities" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;4. Description of Securities</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;5. Interests of Named Experts and Counsel</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C., (&#147;Mintz Levin&#148;).
  </DIV>
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;6. Indemnification of Directors and Officers</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant&#146;s bylaws provide that the Registrant shall, to the full extent and under the
  circumstances permitted by Section&nbsp;145 of the General Corporation Law of the State of Delaware,
  indemnify any person, made or threatened to be made a party to any threatened, pending or completed
  action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of
  the fact that such person is, was or is about to become an officer, director, employee or agent of
  the Registrant or another enterprise in which the Registrant owns or owned, directly or indirectly,
  an equity interest or of which it may be a creditor. The Registrant shall pay the expenses
  (including attorneys&#146; fees) incurred by a person in defending any proceeding in advance of its
  final disposition, provided, however, that, to the extent required by law, such payment of expenses
  in advance of the final disposition of the proceeding shall be made by the Registrant only upon
  receipt of an undertaking by the person to repay all amounts advanced if it should be ultimately
  determined that the person is not entitled to be indemnified.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In addition, the Registrant&#146;s certificate of incorporation eliminates or limits personal
  liability of its directors to the full extent permitted by Section&nbsp;102(b)(7) of the General
  Corporation Law of the State of Delaware.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;102(b)(7) of the General Corporation Law of the State of Delaware provides that a
  corporation may eliminate or limit the personal liability of a director to the corporation or its
  stockholders for monetary damages for breach of fiduciary duty as a director, provided that such
  provision shall not eliminate or limit the liability of a director (i)&nbsp;for any breach of the
  director&#146;s duty of loyalty to the corporation or its stockholders, (ii)&nbsp;for acts or omissions not
  in good faith or which involve intentional misconduct or a knowing violation of law, (iii)&nbsp;for
  willful or negligent conduct in paying dividends, repurchasing stock or redeeming stock out of
  other than lawfully available funds or (iv)&nbsp;for any transaction from which the director derived an
  improper personal benefit. This Section further provides that a corporation shall not eliminate or
  limit the liability of a director for any act or omission occurring prior to the date when the
  applicable provision in the Registrant&#146;s certificate of incorporation became effective.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the General Corporation Law of the State of Delaware provides that a
  corporation has the power to indemnify a director, officer, employee or agent of the corporation
  and certain other persons serving at the request of the corporation in related capacities against
  amounts paid and expenses incurred in connection with an action, suit or proceeding to which such
  person is or is threatened to be made a party by reason of such position, if such person shall have
  acted in good faith and in a manner he reasonably believed to be in or not opposed to the best
  interests of the corporation, and, in any criminal proceeding, if such person had no reasonable
  cause to believe his conduct was unlawful; provided that, in the case of actions brought by or in
  the right of the corporation, no indemnification shall be made with respect to any matter as to
  which such person shall have been adjudged to be liable to the corporation unless and only to the
  extent that the adjudicating court determines that such person is fairly and reasonably entitled to
  indemnification or as the court deems proper.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As permitted under Delaware law, the Registrant has agreements under which it indemnifies its
  executive officers and directors for certain events or occurrences while the officer or director is
  or was serving at the Registrant&#146;s request in such capacity. The term of the indemnification period
  is for the officer&#146;s or director&#146;s lifetime. The maximum potential amount of future payments the
  Registrant could be required to make under these indemnification agreements is unlimited; however,
  the Registrant maintains a director and officer insurance policy that limits its exposure and
  enables it to recover a portion of any future amounts paid.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-2<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link2 "Item&nbsp;7. Exemption from Registration Claimed" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;7. Exemption from Registration Claimed</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;8. Exhibits</U>.
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="4%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="70%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Incorporation of InfoCure Corporation with all amendments (incorporated by
  reference to Exhibit&nbsp;3.1 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended
  December&nbsp;31, 1999, filed with the Commission on March&nbsp;30, 2000) (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Second Amended and Restated Bylaws of InfoCure (incorporated by reference to Exhibit&nbsp;3.2 to
  the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 1999, filed with
  the Commission on March&nbsp;30, 2000) (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen Certificate for shares of common stock (incorporated by reference to Exhibit&nbsp;4.2 to
  the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2004, filed with
  the Commission on March&nbsp;30, 2005) (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, including all exhibits, dated as of December&nbsp;5, 2002, between VitalWorks,
  Inc. and StockTrans, Inc., as Rights Agent (incorporated by reference to Exhibit&nbsp;4 to the
  Registrant&#146;s Current Report on Form&nbsp;8-K, filed with the Commission on December&nbsp;9, 2002)
  (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1*
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1*
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2*
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of BDO Seidman, LLP, Independent Accountants.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1*
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included on the signature page of this Registration Statement).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">AMICAS, Inc. 2007 Employee Stock Purchase Plan (incorporated by reference to the Registrant&#146;s
  definitive Proxy Statement on Schedule&nbsp;14A filed with the Commission on April&nbsp;30, 2007
  (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
  <TD nowrap>*&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Filed herewith</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
  
  </TR>
  
  </TABLE>
  
  
  <!-- link2 "Item&nbsp;9. Undertakings" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;9. Undertakings</U>.
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes:</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">(1)&nbsp;To file, during any period in which offers or sales are being made, a post-effective
  amendment to this registration statement:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act of
  1933;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date of the
  registration statement (or the most recent post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the information set forth in the registration
  statement. Notwithstanding the foregoing, any increase or any decrease in volume of securities
  offered (if the total dollar value of securities offered would not exceed that which was
  registered) and any deviation from the low or high end of the estimated maximum offering range may
  be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
  aggregate, the changes in volume and price
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-3<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">represent no more than a 20% change in the maximum aggregate offering price set forth in the
  &#147;Calculation of Registration Fee&#148; table in the effective Registration Statement;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution
  not previously disclosed in the registration statement or any material change to such information in the
  Registration Statement;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however, </I>That:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) Paragraphs (a)(1)(i) and (a)(1)(ii) of this section do not apply if the Registration
  Statement is on Form S-8, and the information required to be included in a post-effective amendment
  by those paragraphs is contained in reports filed with or furnished to the Commission by the
  Registrant pursuant to Section&nbsp;13 or Section 15(d) of the Securities Exchange Act of 1934 that are
  incorporated by reference in the Registration Statement; and
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) Paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) of this section do not apply if the
  Registration Statement is on Form S-3 or Form F-3 and the information required to be included in a
  post-effective amendment by those paragraphs is contained in reports filed with or furnished to the
  Commission by the Registrant pursuant to Section&nbsp;13 or Section 15(d) of the Securities Exchange Act
  of 1934 that are incorporated by reference in the registration statement, or is contained in a form
  of prospectus filed pursuant to Rule 424(b) that is part of the Registration Statement.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">(2)&nbsp;That, for the purpose of determining any liability under the Securities Act of 1933,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">(3)&nbsp;To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)</TD>
      <TD width="2%">&nbsp;&nbsp;&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant&#146;s annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable,
  each filing of an employee benefit plan&#146;s annual report pursuant to Section 15(d) of the
  Securities Exchange Act of 1934) that is incorporated by reference in this registration
  statement shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be deemed to be the
  initial bona fide offering thereof.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed
  in the Act and is, therefore, unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense
  of any action, suit or proceeding) is asserted by such director, officer or controlling person
  in connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-4<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  
  </TABLE>
  </DIV>
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the City of Boston, Commonwealth of Massachusetts on July&nbsp;31, 2007
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left"><FONT style="font-variant: SMALL-CAPS"><B>AMICAS, INC.</B></FONT><BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
  
  <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Stephen N. Kahane, M.D., M.S.
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top">Name:&nbsp;&nbsp;</TD>
      <TD align="left">Stephen N. Kahane, M.D., M.S.&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top">Title:&nbsp;&nbsp;</TD>
      <TD align="left">Chief Executive Officer and Chairman&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Stephen N. Kahane, M.D.,
  M.S. and Joseph D. Hill, and each of them singly, his true and lawful attorney or attorneys-in-fact
  and agents, with full power to act with or without the others and with full power of substitution
  and resubstitution, to execute in his name, place and stead, in any and all capacities, any or all
  amendments (including post-effective amendments) to this Registration Statement on Form S-8 of
  AMICAS, Inc., and to file the same, with all exhibits thereto and other documents in connection
  therewith, with the Securities and Exchange Commission, granting to the attorneys-in-fact and
  agents, and each of them, full power and authority to do and perform each and every act and thing
  requisite or necessary to be done in or about the premises, as full to all intents and purposes as
  he might or could do in person, hereby ratifying and confirming all that the attorneys-in-fact and
  agents or any of each of them or their substitute may lawfully do or cause to be done by virtue
  hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="25%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;<DIV style="font-size: 10pt; border-bottom: 1px solid #000000">/s/
  Stephen N. Kahane, M.D., M.S.&nbsp;</DIV>
  Stephen
  N. Kahane, M.D., M.S.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="bottom">Chairman of the Board and
  Chief Executive Officer
  (Principal Executive Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="middle">July&nbsp;31, 2007</TD>
  </TR>
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;&nbsp;<DIV style="font-size: 10pt; border-bottom: 1px solid #000000">/s/ Joseph
  D. Hill&nbsp;</DIV>
  Joseph
  D. Hill
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD valign="bottom" align="left">Senior Vice President and
  Chief Financial Officer
  (Principal Financial
  and Accounting Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="middle">July&nbsp;31, 2007</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 10pt; border-bottom: 1px solid #000000">/s/
  Phillip M. Berman, M.D.&nbsp;</DIV>
  Phillip M. Berman, M.D.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">July&nbsp;31, 2007&nbsp;</TD>
  </TR>
  
  
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 10pt; border-bottom: 1px solid #000000">/s/
  Stephen J. Denelsky
  &nbsp;</DIV>
  Stephen J. Denelsky
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">July&nbsp;31, 2007&nbsp;</TD>
  </TR>
  <tr><td>&nbsp;</td></tr>
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 10pt; border-bottom: 1px solid #000000">/s/ Stephen J. Lifshatz
  &nbsp;</DIV>
  Stephen J. Lifshatz
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">July&nbsp;31, 2007</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-5<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="25%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ David B. Shepherd&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">July&nbsp;31, 2007</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  David B. Shepherd
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ John J. Sviokla&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">July&nbsp;31, 2007</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  John J. Sviokla
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-6<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="009"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXHIBIT INDEX</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="4%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="70%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Incorporation of InfoCure Corporation with all amendments (incorporated by
  reference to Exhibit&nbsp;3.1 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended
  December&nbsp;31, 1999, filed with the Commission on March&nbsp;30, 2000) (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Second Amended and Restated Bylaws of InfoCure (incorporated by reference to Exhibit&nbsp;3.2 to
  the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 1999, filed with
  the Commission on March&nbsp;30, 2000) (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen Certificate for shares of common stock (incorporated by reference to Exhibit&nbsp;4.2 to
  the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2004, filed with
  the Commission on March&nbsp;30, 2005) (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, including all exhibits, dated as of December&nbsp;5, 2002, between VitalWorks,
  Inc. and StockTrans, Inc., as Rights Agent (incorporated by reference to Exhibit&nbsp;4 to the
  Registrant&#146;s Current Report on Form&nbsp;8-K, filed with the Commission on December&nbsp;9, 2002)
  (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1*
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1*
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2*
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of BDO Seidman, LLP, Independent Accountants.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1*
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included on the signature page of this Registration Statement).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">AMICAS, Inc. 2007 Employee Stock Purchase Plan (incorporated by reference to the Registrant&#146;s
  definitive Proxy Statement on Schedule&nbsp;14A filed with the Commission on April&nbsp;30, 2007
  (Registration No.&nbsp;000-25311).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
  <TD nowrap>*&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Filed herewith</TD>
  <TD nowrap align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
  
  </TR>
  
  </TABLE>
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-7<!-- /Folio -->
  </DIV>
  
  
  </BODY>
  </HTML>
metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "b66325aisv8.htm", "description": "AMICAS, INC.", "secsgml_size_bytes": 58585}]
metadata_filer: {"company-data": {"conformed-name": "AMICAS, Inc.", "cik": "0001028584", "assigned-sic": "7372", "irs-number": "592248411", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-144995", "film-number": "071013399"}, "business-address": {"street1": "20 GUEST STREET", "street2": "SUITE 400", "city": "BOSTON", "state": "MA", "zip": "02135", "phone": "617-779-7221"}, "mail-address": {"street1": "20 GUEST STREET", "street2": "SUITE 400", "city": "BOSTON", "state": "MA", "zip": "02135"}, "former-company": [{"former-conformed-name": "VITALWORKS INC", "date-changed": "20010809"}, {"former-conformed-name": "VITAL WORKS INC", "date-changed": "20010806"}, {"former-conformed-name": "INFOCURE CORP", "date-changed": "19961209"}]}
text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on July 31, 2007
  REGISTRATION NO. 333 —
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  under the
  SECURITIES ACT OF 1933
  AMICAS, Inc.
  (
  Exact Name of Registrant as Specified in Its Charter)
  Delaware
  59-2248411
  (
  State or Other Jurisdiction
  of Incorporation or Organization
  )
  (
  I.R.S. Employer
  Identification No.
  )
  20 Guest Street, Suite 400
  Boston, Massachusetts 02135
  (
  Address, Including Zip Code, of Principal Executive Offices
  )
  AMICAS, INC. 2007 EMPLOYEE STOCK PURCHASE PLAN
  (Full Titles of the Plan)
  Stephen N. Kahane, M.D., M.S.
  20 Guest Street, Suite 400
  Boston, Massachusetts 02135
  (
  Name, Address and Telephone Number, Including
  Area Code, of Agent For Service
  )
  Copies to:
  Darin P. Smith, Esq.
  Wendy B. Silverman, Esq.
  Mintz, Levin, Cohn, Ferris, Glovsky
  and Popeo, P.C.
  One Financial Center
  Boston, Massachusetts 02111
  (617) 542-6000
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  Title of
  Maximum
  Maximum
  Amount of
  Securities to be
  Amount to be
  Offering Price
  Aggregate
  Registration
  Registered
  Registered
  (1)
  Per Share
  (2)
  Offering Price
  (2)
  Fee
  Common Stock,
  $0.001 par value
  750,000 shares
  $3.47
  $2,602,500
  $79.90
  Rights to purchase
  Series B Preferred
  Stock
  (3)
  (3)
  (3)
  None
  (1)
  The number of shares of common stock, par value $0.001 per share ("Common Stock"), stated
  above consists of the aggregate number of shares which may be purchased under the AMICAS, Inc.
  2007 Employee Stock Purchase Plan (the "2007 Stock Plan"). The maximum number of shares which
  may be purchased under the 2007 Stock Plan is subject to adjustment in accordance with certain
  anti-dilution and other provisions of the 2007 Stock Plan. Accordingly, pursuant to Rule 416
  under the Securities Act of 1933, as amended (the "Securities Act"), this Registration
  Statement covers, in addition to the number of shares stated above, an indeterminate number of
  shares which may be otherwise issuable after the operation of any such anti-dilution and other
  provisions of the 2007 Stock Plan.
  (2)
  This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(c) and (h) under the Securities Act, and based upon the average
  of the high and low prices of the Registrant's Common Stock as reported on the Nasdaq Global
  Market on July 27, 2007.
  (3)
  No separate consideration will be received for the Rights to purchase Series B Preferred
  Stock (the "Rights").
  Table of Contents
  EXPLANATORY NOTE
  In accordance with the instructional Note to Part I of Form S-8 as promulgated by the
  Securities and Exchange Commission (the "Commission"), the information specified by Part I of Form
  S-8 has been omitted from this Registration Statement on Form S-8 for offers to purchase Common
  Stock pursuant to the 2007 Stock Plan.
  TABLE OF CONTENTS
  PART II
  Item 3. Incorporation of Documents by Reference
  Item 4. Description of Securities
  Item 5. Interests of Named Experts and Counsel
  Item 6. Indemnification of Directors and Officers
  Item 7. Exemption from Registration Claimed
  Item 8. Exhibits
  Item 9. Undertakings
  SIGNATURES
  EXHIBIT INDEX
  Ex-5.1 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  Ex-23.2 Consent of BDO Seidman, LLP
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference
  .
  The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  1.
  The Registrant's Annual Report on Form 10-K for the year ended December 31, 2006, filed
  with the Commission on March 16, 2007 (File No. 000-25311).
  2.
  The Registrant's Quarterly Report on Form 10-Q for the quarterly period ended March 31,
  2007, filed with the Commission on May 10, 2007 (File No. 000-25311).
  3.
  The Registrant's Current Report on Form 8-K, filed with the Commission on July 10, 2007
  (File No. 000-25311).
  4.
  The Registrant's Current Report on Form 8-K, filed with the Commission on June 15, 2007
  (File No. 000-25311).
  5.
  The Registrant's Current Report on Form 8-K, filed with the Commission on April 30, 2007
  (except with respect to the items reported under Item 2.02 of such Form 8-K) (File No. 000-
  25311).
  6.
  The Registrant's Current Report on Form 8-K, filed with the Commission on March 1, 2007
  (except with respect to the items reported under Item 2.02 of such Form 8-K) (File No. 000-
  25311).
  7.
  The Registrant's Current Report on Form 8-K, filed with the Commission on February 7,
  2007 (File No. 000-25311).
  8.
  The description of the Registrant's Common Stock contained in the Registrant's
  Registration Statement on Form 8-A (File No. 000-25311) filed with the Commission on January
  28, 1999 under the Securities Exchange Act of 1934, as amended (the "Exchange Act"),
  including any amendment or report filed for the purpose of updating such description.
  9.
  The description of the Registrant's Common Stock contained in the Registrant's
  Registration Statement on Form 8-A (File No. 000-12799) filed with the Commission on March
  12, 1997 under the Exchange Act, including any amendment or report filed for the purpose of
  updating such description.
  10.
  The description of the Rights under the Registrant's Rights Agreement (which are
  currently transferred with the Registrant's Common Stock) contained in the Registrant's
  Registration Statement on Form 8-A (File No. 000-25311) filed with the Commission on April
  2, 2003 under the Exchange Act, including any amendment or report for the purpose of
  updating such description.
  11.
  The description of the Rights under the Registrant's Rights Agreement (which are
  currently transferred with the Registrant's Common Stock) contained in the Registrant's
  Registration Statement on Form 8-A (File No. 000-12799) filed with the Commission on January
  3, 2003 under the Exchange Act, including any amendment or report for the purpose of
  updating such description.
  All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
  amendment which indicates that all securities offered hereby have been sold or which deregisters
  all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to
  be part hereof from the date of filing of such reports and documents. Any statement contained in a
  document incorporated or deemed to be incorporated by reference herein shall be deemed
  II-1
  Table of Contents
  to be modified or superseded for the purposes of this registration statement to the extent that a
  statement contained herein or in any other subsequently filed document which also is or is deemed
  to be incorporated by reference herein modifies or supersedes such statement. Any statement so
  modified or superseded shall not be deemed, except as so modified or superseded, to constitute a
  part of this registration statement.
  Item 4. Description of Securities
  .
  Not applicable.
  Item 5. Interests of Named Experts and Counsel
  .
  The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C., ("Mintz Levin").
  Item 6. Indemnification of Directors and Officers
  .
  The Registrant's bylaws provide that the Registrant shall, to the full extent and under the
  circumstances permitted by Section 145 of the General Corporation Law of the State of Delaware,
  indemnify any person, made or threatened to be made a party to any threatened, pending or completed
  action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of
  the fact that such person is, was or is about to become an officer, director, employee or agent of
  the Registrant or another enterprise in which the Registrant owns or owned, directly or indirectly,
  an equity interest or of which it may be a creditor. The Registrant shall pay the expenses
  (including attorneys' fees) incurred by a person in defending any proceeding in advance of its
  final disposition, provided, however, that, to the extent required by law, such payment of expenses
  in advance of the final disposition of the proceeding shall be made by the Registrant only upon
  receipt of an undertaking by the person to repay all amounts advanced if it should be ultimately
  determined that the person is not entitled to be indemnified.
  In addition, the Registrant's certificate of incorporation eliminates or limits personal
  liability of its directors to the full extent permitted by Section 102(b)(7) of the General
  Corporation Law of the State of Delaware.
  Section 102(b)(7) of the General Corporation Law of the State of Delaware provides that a
  corporation may eliminate or limit the personal liability of a director to the corporation or its
  stockholders for monetary damages for breach of fiduciary duty as a director, provided that such
  provision shall not eliminate or limit the liability of a director (i) for any breach of the
  director's duty of loyalty to the corporation or its stockholders, (ii) for acts or omissions not
  in good faith or which involve intentional misconduct or a knowing violation of law, (iii) for
  willful or negligent conduct in paying dividends, repurchasing stock or redeeming stock out of
  other than lawfully available funds or (iv) for any transaction from which the director derived an
  improper personal benefit. This Section further provides that a corporation shall not eliminate or
  limit the liability of a director for any act or omission occurring prior to the date when the
  applicable provision in the Registrant's certificate of incorporation became effective.
  Section 145 of the General Corporation Law of the State of Delaware provides that a
  corporation has the power to indemnify a director, officer, employee or agent of the corporation
  and certain other persons serving at the request of the corporation in related capacities against
  amounts paid and expenses incurred in connection with an action, suit or proceeding to which such
  person is or is threatened to be made a party by reason of such position, if such person shall have
  acted in good faith and in a manner he reasonably believed to be in or not opposed to the best
  interests of the corporation, and, in any criminal proceeding, if such person had no reasonable
  cause to believe his conduct was unlawful; provided that, in the case of actions brought by or in
  the right of the corporation, no indemnification shall be made with respect to any matter as to
  which such person shall have been adjudged to be liable to the corporation unless and only to the
  extent that the adjudicating court determines that such person is fairly and reasonably entitled to
  indemnification or as the court deems proper.
  As permitted under Delaware law, the Registrant has agreements under which it indemnifies its
  executive officers and directors for certain events or occurrences while the officer or director is
  or was serving at the Registrant's request in such capacity. The term of the indemnification period
  is for the officer's or director's lifetime. The maximum potential amount of future payments the
  Registrant could be required to make under these indemnification agreements is unlimited; however,
  the Registrant maintains a director and officer insurance policy that limits its exposure and
  enables it to recover a portion of any future amounts paid.
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  Table of Contents
  Item 7. Exemption from Registration Claimed
  .
  Not applicable.
  Item 8. Exhibits
  .
  Exhibit
  Number
  Description
  4.1
  Certificate of Incorporation of InfoCure Corporation with all amendments (incorporated by
  reference to Exhibit 3.1 to the Registrant's Annual Report on Form 10-K for the year ended
  December 31, 1999, filed with the Commission on March 30, 2000) (Registration No. 000-25311).
  4.2
  Second Amended and Restated Bylaws of InfoCure (incorporated by reference to Exhibit 3.2 to
  the Registrant's Annual Report on Form 10-K for the year ended December 31, 1999, filed with
  the Commission on March 30, 2000) (Registration No. 000-25311).
  4.3
  Specimen Certificate for shares of common stock (incorporated by reference to Exhibit 4.2 to
  the Registrant's Annual Report on Form 10-K for the year ended December 31, 2004, filed with
  the Commission on March 30, 2005) (Registration No. 000-25311).
  4.4
  Rights Agreement, including all exhibits, dated as of December 5, 2002, between VitalWorks,
  Inc. and StockTrans, Inc., as Rights Agent (incorporated by reference to Exhibit 4 to the
  Registrant's Current Report on Form 8-K, filed with the Commission on December 9, 2002)
  (Registration No. 000-25311).
  5.1*
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered.
  23.1*
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit 5).
  23.2*
  Consent of BDO Seidman, LLP, Independent Accountants.
  24.1*
  Power of Attorney (included on the signature page of this Registration Statement).
  99.1
  AMICAS, Inc. 2007 Employee Stock Purchase Plan (incorporated by reference to the Registrant's
  definitive Proxy Statement on Schedule 14A filed with the Commission on April 30, 2007
  (Registration No. 000-25311).
  *     Filed herewith
  Item 9. Undertakings
  .
  (a)
  The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made, a post-effective
  amendment to this registration statement:
  (i) To include any prospectus required by Section 10(a)(3) of the Securities Act of
  1933;
  (ii) To reflect in the prospectus any facts or events arising after the effective date of the
  registration statement (or the most recent post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the information set forth in the registration
  statement. Notwithstanding the foregoing, any increase or any decrease in volume of securities
  offered (if the total dollar value of securities offered would not exceed that which was
  registered) and any deviation from the low or high end of the estimated maximum offering range may
  be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
  aggregate, the changes in volume and price
  II-3
  Table of Contents
  represent no more than a 20% change in the maximum aggregate offering price set forth in the
  "Calculation of Registration Fee" table in the effective Registration Statement;
  (iii) To include any material information with respect to the plan of distribution
  not previously disclosed in the registration statement or any material change to such information in the
  Registration Statement;
  Provided, however,
  That:
  (A) Paragraphs (a)(1)(i) and (a)(1)(ii) of this section do not apply if the Registration
  Statement is on Form S-8, and the information required to be included in a post-effective amendment
  by those paragraphs is contained in reports filed with or furnished to the Commission by the
  Registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are
  incorporated by reference in the Registration Statement; and
  (B) Paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) of this section do not apply if the
  Registration Statement is on Form S-3 or Form F-3 and the information required to be included in a
  post-effective amendment by those paragraphs is contained in reports filed with or furnished to the
  Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act
  of 1934 that are incorporated by reference in the registration statement, or is contained in a form
  of prospectus filed pursuant to Rule 424(b) that is part of the Registration Statement.
  (2) That, for the purpose of determining any liability under the Securities Act of 1933,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable,
  each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the
  Securities Exchange Act of 1934) that is incorporated by reference in this registration
  statement shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be deemed to be the
  initial bona fide offering thereof.
  (c)
  Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed
  in the Act and is, therefore, unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense
  of any action, suit or proceeding) is asserted by such director, officer or controlling person
  in connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.
  II-4
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the City of Boston, Commonwealth of Massachusetts on July 31, 2007
  AMICAS, INC.
  By:
  /s/ Stephen N. Kahane, M.D., M.S.
  Name:
  Stephen N. Kahane, M.D., M.S.
  Title:
  Chief Executive Officer and Chairman
  Each person whose signature appears below constitutes and appoints Stephen N. Kahane, M.D.,
  M.S. and Joseph D. Hill, and each of them singly, his true and lawful attorney or attorneys-in-fact
  and agents, with full power to act with or without the others and with full power of substitution
  and resubstitution, to execute in his name, place and stead, in any and all capacities, any or all
  amendments (including post-effective amendments) to this Registration Statement on Form S-8 of
  AMICAS, Inc., and to file the same, with all exhibits thereto and other documents in connection
  therewith, with the Securities and Exchange Commission, granting to the attorneys-in-fact and
  agents, and each of them, full power and authority to do and perform each and every act and thing
  requisite or necessary to be done in or about the premises, as full to all intents and purposes as
  he might or could do in person, hereby ratifying and confirming all that the attorneys-in-fact and
  agents or any of each of them or their substitute may lawfully do or cause to be done by virtue
  hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/
  Stephen N. Kahane, M.D., M.S.
  Stephen
  N. Kahane, M.D., M.S.
  Chairman of the Board and
  Chief Executive Officer
  (Principal Executive Officer)
  July 31, 2007
  /s/ Joseph
  D. Hill
  Joseph
  D. Hill
  Senior Vice President and
  Chief Financial Officer
  (Principal Financial
  and Accounting Officer)
  July 31, 2007
  /s/
  Phillip M. Berman, M.D.
  Phillip M. Berman, M.D.
  Director
  July 31, 2007
  /s/
  Stephen J. Denelsky
  Stephen J. Denelsky
  Director
  July 31, 2007
  /s/ Stephen J. Lifshatz
  Stephen J. Lifshatz
  Director
  July 31, 2007
  II-5
  Table of Contents
  Signature
  Title
  Date
  /s/ David B. Shepherd
  Director
  July 31, 2007
  David B. Shepherd
  /s/ John J. Sviokla
  Director
  July 31, 2007
  John J. Sviokla
  II-6
  Table of Contents
  EXHIBIT INDEX
  Exhibit
  Number
  Description
  4.1
  Certificate of Incorporation of InfoCure Corporation with all amendments (incorporated by
  reference to Exhibit 3.1 to the Registrant's Annual Report on Form 10-K for the year ended
  December 31, 1999, filed with the Commission on March 30, 2000) (Registration No. 000-25311).
  4.2
  Second Amended and Restated Bylaws of InfoCure (incorporated by reference to Exhibit 3.2 to
  the Registrant's Annual Report on Form 10-K for the year ended December 31, 1999, filed with
  the Commission on March 30, 2000) (Registration No. 000-25311).
  4.3
  Specimen Certificate for shares of common stock (incorporated by reference to Exhibit 4.2 to
  the Registrant's Annual Report on Form 10-K for the year ended December 31, 2004, filed with
  the Commission on March 30, 2005) (Registration No. 000-25311).
  4.4
  Rights Agreement, including all exhibits, dated as of December 5, 2002, between VitalWorks,
  Inc. and StockTrans, Inc., as Rights Agent (incorporated by reference to Exhibit 4 to the
  Registrant's Current Report on Form 8-K, filed with the Commission on December 9, 2002)
  (Registration No. 000-25311).
  5.1*
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered.
  23.1*
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit 5).
  23.2*
  Consent of BDO Seidman, LLP, Independent Accountants.
  24.1*
  Power of Attorney (included on the signature page of this Registration Statement).
  99.1
  AMICAS, Inc. 2007 Employee Stock Purchase Plan (incorporated by reference to the Registrant's
  definitive Proxy Statement on Schedule 14A filed with the Commission on April 30, 2007
  (Registration No. 000-25311).
  *     Filed herewith
  II-7