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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 25%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 0pt"><B>REGISTRATION STATEMENT<BR>
  UNDER<BR>
  THE SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 25%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>CLINICAL DATA, INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact name of Registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-2573920</B></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or Other Jurisdiction <BR>
  of Incorporation or <BR>
  Organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer Identification<BR>
  Number)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>One Gateway Center, Suite&nbsp;702<BR>
  Newton, MA 02458<BR>
  (617)&nbsp;527-9933</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 1pt; width: 100%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt">(Address of Principal Executive Offices, including Zip Code<BR>
  and Telephone Number)</DIV>
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Amended and Restated 2005 Equity Incentive Plan</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 1pt; width: 100%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt">(Full Title of the Plan)</DIV>
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Andrew J. Fromkin<BR>
  President and Chief Executive Officer<BR>
  Clinical Data, Inc.<BR>
  One Gateway Center, Suite&nbsp;702<BR>
  Newton, MA 02458<BR>
  (617)&nbsp;527-9933</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 1pt; width: 100%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt">(Name, Address, including Zip Code, and Telephone Number,<BR>
  including Area Code,<BR>
  of Agent for Service)</DIV>
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">&nbsp;
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 1pt; width: 100%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt">(with a copy to)<BR>
  John Hession<BR>
  Marc Recht<BR>
  McDermott Will &#038; Emery LLP<BR>
  28 State Street<BR>
  Boston, MA 02109<BR>
  (617)&nbsp;535-4000</DIV>
  
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 25%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CALCULATION OF REGISTRATION FEE</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
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      <TD width="2%">&nbsp;</TD>
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      <TD width="2%">&nbsp;</TD>
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      <TD width="1%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="21" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Proposed Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Proposed Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Amount of</B></TD>
      <TD>&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Amount to be</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Offering Price</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Aggregate Offering</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Registration</B></TD>
      <TD>&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center" style="border-bottom: 0px solid #000000"><B>Title of Securities to be Registered</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2" style="border-bottom: 0px solid #000000"><B>Registered(1)</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2" style="border-bottom: 0px solid #000000"><B>Per Share(2)</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2" style="border-bottom: 0px solid #000000"><B>Price(2)</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2" style="border-bottom: 0px solid #000000"><B>Fee(3)</B></TD>
      <TD>&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par
  value $0.01 per share</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
  
      <TD colspan="4" align="center" style="border-top: 1px solid #000000">1,000,000 shares</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
  
      <TD colspan="2" align="center" style="border-top: 1px solid #000000">$15.35</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
  
      <TD colspan="2" align="center" style="border-top: 1px solid #000000">$15,350,000.00</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
  
      <TD colspan="2" align="center" style="border-top: 1px solid #000000">$1,643.00</TD>
      <TD style="border-top: 0px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 0px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="21" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Plus, pursuant to Rule 416(a) under the Securities Act, such additional number of shares as
  may be required in the event of a stock dividend, split-up of shares or other similar change
  in the Common Stock.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Estimated solely for the purpose of computing the amount of the registration fee under Rules
  457(c) and 457(h)(1) based on the average of the high and low price per share of the
  Registrant&#146;s Common Stock on the NASDAQ Global Market on November&nbsp;9, 2006.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>This Registration Statement registers an additional 1,000,000 shares issuable under our
  Amended and Restated 2005 Equity Incentive Plan (the &#147;<U><I>Plan</I></U>&#148;). We have previously
  registered 1,000,000 shares issuable under the Plan prior to its amendment (Registration
  Statement No.&nbsp;333-129634).</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#000">Statement Regarding Incorporation of Documents By Reference From Effective Registration Statements.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;8.&nbsp;&nbsp;&nbsp; Exhibits.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#002">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003">POWER OF ATTORNEY</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#004">EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b63107cdexv5w1.htm">Ex-5.1 Opinion of McDermott Will & Emery LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b63107cdexv23w1.htm">Ex-23.1 Consent of Deloitte & Touche LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link2 "Statement Regarding Incorporation of Documents By Reference From Effective Registration Statements." -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Statement Regarding Incorporation of Documents By Reference From Effective Registration
  Statements.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement registers additional securities of the same class as other
  securities for which a registration statement filed on Form S-8 relating to our Amended and
  Restated 2005 Equity Incentive Plan (the &#147;<U><I>Plan</I></U>&#148;) is already effective. Pursuant to
  Instruction E to Form S-8, we incorporate by reference into this Registration Statement the
  contents of the registration statement we filed on Form S-8 (File No.&nbsp;333-129634) with the
  Securities and Exchange Commission on November&nbsp;10, 2005 in its entirety, including exhibits
  thereto, relating to the registration of 1,000,000 shares of our Common Stock, $0.01 par value per
  share, authorized for issuance under the Plan. This Registration Statement provides for the
  registration of an additional 1,000,000 shares of our Common Stock authorized for issuance under
  the Plan.
  </DIV>
  <!-- link2 "Item&nbsp;8.&nbsp;&nbsp;&nbsp; Exhibits." -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8.&nbsp;&nbsp;&nbsp; Exhibits.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Exhibit&nbsp;Index immediately following the signature pages is incorporated by reference herein.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->-1-<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the
  Registrant certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on
  its behalf by the undersigned, thereunto duly authorized, in the Town of Newton, Commonwealth of
  Massachusetts, on November&nbsp;16, 2006.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">CLINICAL DATA, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="center">/s/ Andrew J. Fromkin
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="center">Andrew J. Fromkin&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="center"><I>President and Chief Executive Officer<br></I>
  <I>Principal Executive Officer</I>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="center">                                   /s/ C. Evan Ballantyne
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="center">C. Evan Ballantyne&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="center"><I>Senior Vice President and Chief Financial Officer<br>
  Principal Financial and Accounting Officer</I>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  <!-- link1 "POWER OF ATTORNEY" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>POWER OF ATTORNEY</B>
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below hereby constitutes and appoints Andrew J. Fromkin
  and Caesar J. Belbel or either of them, his true and lawful attorneys and agent, with full power of
  substitution, and with power to act alone, to sign on behalf of the undersigned any amendment or
  amendments to this registration statement on Form S-8 (including pre- and post-effective
  amendments) and to perform any acts necessary to file such amendments, with exhibits thereto and
  other documents in connection therewith, and each of the undersigned does hereby ratify and confirm
  his signature as it may be signed by his said attorneys and agents to any and all such documents
  and all that said attorneys and agents, or their substitutes, shall do or cause to be done by
  virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this registration statement has
  been signed by the following persons in the capacities and as of the dates indicated.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="20%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 10pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="right">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" nowrap valign="top"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Randal J. Kirk
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Randal J. Kirk</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">November 16, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Andrew J. Fromkin
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Andrew J. Fromkin</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  President, Chief Executive
  Officer and Director
  (Principal Executive Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">November 16, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Larry D. Horner
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Larry D. Horner</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">November 16, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Arthur B. Malman
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Arthur B. Malman</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">November 16, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Burton E. Sobel
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Burton E. Sobel, M.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">November 16, 2006</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Kevin L. Rakin
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Kevin L. Rakin</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">November 16, 2006</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-1<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link1 "EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXHIBIT INDEX</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="12%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="86%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 10pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 0px solid #000000"><B><U>Exhibit No.</U></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 0px solid #000000"><B><U>Description</U></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Incorporation. Filed as Exhibit&nbsp;3.1 to the Company&#146;s Registration
  Statement on Form&nbsp;S-1 (File No.&nbsp;2-82494), as filed with the Commission on March
  17, 1983, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Certificate of Incorporation filed with the Secretary
  of State of the State of Delaware on October&nbsp;1, 2003. Filed as Exhibit&nbsp;3.1 to
  the Company&#146;s Quarterly Report on Form&nbsp;10-Q, as filed with the Commission on
  February&nbsp;17, 2004, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Elimination of the Series&nbsp;A Nonvoting Convertible Preferred Stock
  filed with the Secretary of State of the State of Delaware on July&nbsp;7, 2005.
  Filed as Exhibit&nbsp;3.1 to the Company&#146;s Current Report on Form&nbsp;8-K, as filed with
  the Commission on July&nbsp;11, 2005, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Designation of the Series&nbsp;A Preferred Stock filed with the
  Secretary of State of the State of Delaware on October&nbsp;4, 2005. Filed as Exhibit
  3.2 to the Company&#146;s Current Report on Form&nbsp;8-K, filed with the Commission on
  October&nbsp;11, 2005, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Certificate of Incorporation filed with the Secretary
  of State of the State of Delaware on October&nbsp;6, 2005. Filed as Exhibit&nbsp;3.1 to
  the Company&#146;s Current Report on Form&nbsp;8-K, filed with the Commission on October
  11, 2005, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.6
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated By-laws of the Company, as of June&nbsp;20, 2005. Filed as
  Exhibit&nbsp;3.1 to the Company&#146;s Current Report on Form&nbsp;8-K, filed with the
  Commission on June&nbsp;24, 2005, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.7
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen Common Stock Certificate. Filed as Exhibit&nbsp;4.1 to the Company&#146;s
  Registration Statement on Form&nbsp;S-1 (File No.&nbsp;2-82494), as filed with the
  Commission on March&nbsp;17, 1983, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.8
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen Series&nbsp;A Preferred Stock Certificate. Filed as Exhibit&nbsp;4.2 to the
  Company&#146;s Annual Report on Form&nbsp;10-K, as filed with the Commission on June&nbsp;29,
  2006, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.9
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated 2005 Equity Incentive Plan. Filed as Exhibit&nbsp;10.3 to
  Clinical Data&#146;s Quarterly Report on Form&nbsp;10-Q, as filed with the Commission on
  November&nbsp;14, 2006, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of McDermott Will &#038; Emery LLP as to the validity of the common stock of
  Clinical Data being registered hereby, together with consent.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP, Clinical Data&#146;s independent registered public
  accounting firm.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of McDermott Will &#038; Emery LLP (included in Exhibit&nbsp;5.1).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included in the signature page of this registration statement).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-2<!-- /Folio -->
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  Registration No. 333-
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  CLINICAL DATA, INC.
  (Exact name of Registrant as specified in its charter)
  Delaware
  04-2573920
  (State or Other Jurisdiction
  of Incorporation or
  Organization)
  (I.R.S. Employer Identification
  Number)
  One Gateway Center, Suite 702
  Newton, MA 02458
  (617) 527-9933
  (Address of Principal Executive Offices, including Zip Code
  and Telephone Number)
  Amended and Restated 2005 Equity Incentive Plan
  (Full Title of the Plan)
  Andrew J. Fromkin
  President and Chief Executive Officer
  Clinical Data, Inc.
  One Gateway Center, Suite 702
  Newton, MA 02458
  (617) 527-9933
  (Name, Address, including Zip Code, and Telephone Number,
  including Area Code,
  of Agent for Service)
  (with a copy to)
  John Hession
  Marc Recht
  McDermott Will & Emery LLP
  28 State Street
  Boston, MA 02109
  (617) 535-4000
  CALCULATION OF REGISTRATION FEE
  Proposed Maximum
  Proposed Maximum
  Amount of
  Amount to be
  Offering Price
  Aggregate Offering
  Registration
  Title of Securities to be Registered
  Registered(1)
  Per Share(2)
  Price(2)
  Fee(3)
  Common Stock, par
  value $0.01 per share
  1,000,000 shares
  $15.35
  $15,350,000.00
  $1,643.00
  (1)
  Plus, pursuant to Rule 416(a) under the Securities Act, such additional number of shares as
  may be required in the event of a stock dividend, split-up of shares or other similar change
  in the Common Stock.
  (2)
  Estimated solely for the purpose of computing the amount of the registration fee under Rules
  457(c) and 457(h)(1) based on the average of the high and low price per share of the
  Registrant's Common Stock on the NASDAQ Global Market on November 9, 2006.
  (3)
  This Registration Statement registers an additional 1,000,000 shares issuable under our
  Amended and Restated 2005 Equity Incentive Plan (the "
  Plan
  "). We have previously
  registered 1,000,000 shares issuable under the Plan prior to its amendment (Registration
  Statement No. 333-129634).
  TABLE OF CONTENTS
  Statement Regarding Incorporation of Documents By Reference From Effective Registration Statements.
  Item 8.    Exhibits.
  SIGNATURES
  POWER OF ATTORNEY
  EXHIBIT INDEX
  Ex-5.1 Opinion of McDermott Will & Emery LLP
  Ex-23.1 Consent of Deloitte & Touche LLP
  Table of Contents
  Statement Regarding Incorporation of Documents By Reference From Effective Registration
  Statements.
  This Registration Statement registers additional securities of the same class as other
  securities for which a registration statement filed on Form S-8 relating to our Amended and
  Restated 2005 Equity Incentive Plan (the "
  Plan
  ") is already effective. Pursuant to
  Instruction E to Form S-8, we incorporate by reference into this Registration Statement the
  contents of the registration statement we filed on Form S-8 (File No. 333-129634) with the
  Securities and Exchange Commission on November 10, 2005 in its entirety, including exhibits
  thereto, relating to the registration of 1,000,000 shares of our Common Stock, $0.01 par value per
  share, authorized for issuance under the Plan. This Registration Statement provides for the
  registration of an additional 1,000,000 shares of our Common Stock authorized for issuance under
  the Plan.
  Item 8.    Exhibits.
  The Exhibit Index immediately following the signature pages is incorporated by reference herein.
  -1-
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the
  Registrant certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on
  its behalf by the undersigned, thereunto duly authorized, in the Town of Newton, Commonwealth of
  Massachusetts, on November 16, 2006.
  CLINICAL DATA, INC.
  By:
  /s/ Andrew J. Fromkin
  Andrew J. Fromkin
  President and Chief Executive Officer
  Principal Executive Officer
  By:
  /s/ C. Evan Ballantyne
  C. Evan Ballantyne
  Senior Vice President and Chief Financial Officer
  Principal Financial and Accounting Officer
  POWER OF ATTORNEY
  Each person whose signature appears below hereby constitutes and appoints Andrew J. Fromkin
  and Caesar J. Belbel or either of them, his true and lawful attorneys and agent, with full power of
  substitution, and with power to act alone, to sign on behalf of the undersigned any amendment or
  amendments to this registration statement on Form S-8 (including pre- and post-effective
  amendments) and to perform any acts necessary to file such amendments, with exhibits thereto and
  other documents in connection therewith, and each of the undersigned does hereby ratify and confirm
  his signature as it may be signed by his said attorneys and agents to any and all such documents
  and all that said attorneys and agents, or their substitutes, shall do or cause to be done by
  virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this registration statement has
  been signed by the following persons in the capacities and as of the dates indicated.
  Signature
  Title
  Date
  /s/ Randal J. Kirk
  Randal J. Kirk
  Chairman of the Board
  November 16, 2006
  /s/ Andrew J. Fromkin
  Andrew J. Fromkin
  President, Chief Executive
  Officer and Director
  (Principal Executive Officer)
  November 16, 2006
  /s/ Larry D. Horner
  Larry D. Horner
  Director
  November 16, 2006
  /s/ Arthur B. Malman
  Arthur B. Malman
  Director
  November 16, 2006
  /s/ Burton E. Sobel
  Burton E. Sobel, M.D.
  Director
  November 16, 2006
  /s/ Kevin L. Rakin
  Kevin L. Rakin
  Director
  November 16, 2006
  II-1
  Table of Contents
  EXHIBIT INDEX
  Exhibit No.
  Description
  4.1
  Certificate of Incorporation. Filed as Exhibit 3.1 to the Company's Registration
  Statement on Form S-1 (File No. 2-82494), as filed with the Commission on March
  17, 1983, and incorporated herein by reference.
  4.2
  Certificate of Amendment of Certificate of Incorporation filed with the Secretary
  of State of the State of Delaware on October 1, 2003. Filed as Exhibit 3.1 to
  the Company's Quarterly Report on Form 10-Q, as filed with the Commission on
  February 17, 2004, and incorporated herein by reference.
  4.3
  Certificate of Elimination of the Series A Nonvoting Convertible Preferred Stock
  filed with the Secretary of State of the State of Delaware on July 7, 2005.
  Filed as Exhibit 3.1 to the Company's Current Report on Form 8-K, as filed with
  the Commission on July 11, 2005, and incorporated herein by reference.
  4.4
  Certificate of Designation of the Series A Preferred Stock filed with the
  Secretary of State of the State of Delaware on October 4, 2005. Filed as Exhibit
  3.2 to the Company's Current Report on Form 8-K, filed with the Commission on
  October 11, 2005, and incorporated herein by reference.
  4.5
  Certificate of Amendment of Certificate of Incorporation filed with the Secretary
  of State of the State of Delaware on October 6, 2005. Filed as Exhibit 3.1 to
  the Company's Current Report on Form 8-K, filed with the Commission on October
  11, 2005, and incorporated herein by reference.
  4.6
  Amended and Restated By-laws of the Company, as of June 20, 2005. Filed as
  Exhibit 3.1 to the Company's Current Report on Form 8-K, filed with the
  Commission on June 24, 2005, and incorporated herein by reference.
  4.7
  Specimen Common Stock Certificate. Filed as Exhibit 4.1 to the Company's
  Registration Statement on Form S-1 (File No. 2-82494), as filed with the
  Commission on March 17, 1983, and incorporated herein by reference.
  4.8
  Specimen Series A Preferred Stock Certificate. Filed as Exhibit 4.2 to the
  Company's Annual Report on Form 10-K, as filed with the Commission on June 29,
  2006, and incorporated herein by reference.
  4.9
  Amended and Restated 2005 Equity Incentive Plan. Filed as Exhibit 10.3 to
  Clinical Data's Quarterly Report on Form 10-Q, as filed with the Commission on
  November 14, 2006, and incorporated herein by reference.
  5.1
  Opinion of McDermott Will & Emery LLP as to the validity of the common stock of
  Clinical Data being registered hereby, together with consent.
  23.1
  Consent of Deloitte & Touche LLP, Clinical Data's independent registered public
  accounting firm.
  23.2
  Consent of McDermott Will & Emery LLP (included in Exhibit 5.1).
  24.1
  Power of Attorney (included in the signature page of this registration statement).
  II-2