content: <HTML>
  <HEAD>
  <TITLE>sv8</TITLE>
  </HEAD>
  <BODY bgcolor="#FFFFFF">
  <!-- PAGEBREAK -->
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P align="center" style="font-size: 10pt"><B>As filed with the
  Securities and Exchange Commission on June&nbsp;14, 2005</B>
  
  
  
  <DIV align="right" style="font-size: 10pt"><B>File No.&nbsp;333-______</B></DIV>
  
  
  <P>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  
  
  <P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, DC 20549</B>
  </DIV>
  
  <P>
  <HR noshade size="1" width="26%" align="center" color="#000000">
  
  <div align="center" style="font-size: 18pt"><B>FORM S-8</B>
  </div>
  
  <P align="center" style="font-size: 12pt"><B>REGISTRATION STATEMENT<BR>
  UNDER<BR>
  THE SECURITIES ACT OF 1933</B>
  <div align="center" style="font-size: 12pt"><HR size="1" noshade width="26%" align="center" color="#000000">
  </div>
  
  <DIV align="center" style="font-size: 24pt"><B>ACCESS
  PHARMACEUTICALS, INC.</B></DIV>
  
  
  <DIV align="center" style="font-size: 10pt"><I>(Exact Name of Registrant as Specified in Its Charter)</I></DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>DELAWARE</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>83-0221517</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><I>(State or Other Jurisdiction of Incorporation or</I>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><I>(I.R.S. Employer</I></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><I>Organization)</I>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><I>Identification No.)</I></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><B>2600 Stemmons Freeway, Suite&nbsp;176<BR>
  Dallas, Texas 75207</B><BR>
  <I>(Address of Principal Executive Offices) (Zip Code)</I>
  
  
  
  <DIV align="center" style="font-size: 10pt"><HR size="1" noshade width="26%" align="center" color="#000000"></DIV>
  
  
  
  <div align="center" style="font-size: 10pt"><B>ACCESS PHARMACEUTICALS, INC.<BR>
  2005 EQUITY INCENTIVE PLAN<BR>
  2001 RESTRICTED STOCK PLAN</B><BR>
  <I>(Full Title of the Plan)</I>
  </div>
  
  
  <div align="center" style="font-size: 10pt"><HR size="1" noshade width="26%" align="center" color="#000000">
  </div>
  
  
  <DIV align="center" style="font-size: 10pt"><B>Stephen B. Thompson<BR>
  Chief Financial Officer<BR>
  Access Pharmaceuticals, Inc.<BR>
  2600 Stemmons Freeway, Suite&nbsp;176<BR>
  Dallas, Texas 75207</B><BR>
  <I>(Name and Address of Agent For Service)</I></DIV>
  
  
  
  <P align="center" style="font-size: 10pt"><B>(214)&nbsp;905-5100</B><BR>
  <I>Telephone Number, Including Area Code, of Agent for Service</I>
  
  
  
  <div align="center" style="font-size: 10pt"><HR size="1" noshade width="26%" align="center" color="#000000">
  </div>
  
  
  <div align="center" style="font-size: 10pt"><I>Copies to:</I><BR><BR>
  <B>John J. Concannon III, Esq.</B><BR>
  Bingham McCutchen LLP<BR>
  150 Federal Street<BR>
  Boston, MA 02110-1726<BR>
  (617)&nbsp;951-8000
  </div>
  
  <P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="62%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD>&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Proposed</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Proposed</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">       <TD>&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Amount</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Amount Of</B></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">       <TD>&nbsp;</TD>
  
      <TD nowrap align="center"><B>Title Of</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>To Be</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Offering Price</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Aggregate</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Registration</B></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">       <TD>&nbsp;</TD>
  
      <TD nowrap align="center"><B>Securities To Be Registered</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Registered</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Per Share</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Offering Price </B><SUP style="font-size: 85%; vertical-align: text-top"><B>(1)</B></SUP></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Fee</B></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock,
  $0.01 par value</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">900,000</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="left" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">2.20</TD>
      <TD nowrap style="border-top: 1px solid #000000"><SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">1,980,000</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">233.05</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P>
  <HR size="1" width="18%" align="left" noshade color="#000000">
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top">
      <TD width="1%" nowrap align="left">(1)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Estimated solely for purposes of computing the registration fee pursuant to Rule
  457(h) under the Securities Act of 1933, as amended, based on the average of the high
  and low prices of the Registrant&#146;s Common Stock, $0.01 par value per share, reported
  by the American Stock Exchange on June&nbsp;9, 2005.</TD>
  </TR>
  
  </TABLE>
  
  
  
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000"> PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;4. Description of Securities</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;5. Interests of Named Experts or Counsel</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;7. Exemption From Registration Claimed</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;8. Exhibits</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;9. Undertakings</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#008"> SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#009"> EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55431apexv4w5.htm">EX-4.5 FORM OF 2005 EQUITY INCENTIVE PLAN STOCK OPTION AGREEMENT</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55431apexv4w6.htm">EX-4.6 FORM OF 2005 EQUITY INCENTIVE PLAN RESTRICTED STOCK GRANT AGREEMENT</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55431apexv4w7.htm">EX-4.7 FORM OF 1995 STOCK AWARDS GRANT</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55431apexv5.htm">EX-5 OPINION OF BINGHAM MCCUTCHEN LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55431apexv23w1.htm">EX-23.1 CONSENT OF GRANT THORNTON LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link1 " PART II " -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>PART II</B>
  
  
  
  <P align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  
  <!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;3. </B><B><I>Incorporation of Documents by Reference.</I></B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Access Pharmaceuticals, Inc. (the &#147;Registrant&#148;) incorporates by reference the documents listed
  below and any future filings the Registrant will make with the SEC under Section&nbsp;13(a), 13(c), 14
  or 15(d) of the Securities Exchange Act of 1934, as amended:
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">--&nbsp;&nbsp;</TD>
      <TD>Annual Report on Form 10-K for the year ended December&nbsp;31, 2004;</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">--&nbsp;&nbsp;</TD>
      <TD>Quarterly Report on Form 10-Q for the quarter ended March&nbsp;31, 2005;</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">--&nbsp;&nbsp;</TD>
      <TD>Current Reports on Form 8-K filed on January&nbsp;31, 2005, March&nbsp;16, 2005,
  April&nbsp;1, 2005, May&nbsp;4, 2005 and May&nbsp;16, 2005; and</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">--&nbsp;&nbsp;</TD>
      <TD>the description of the Registrant&#146;s common stock contained in its
  registration statement on Form 8-A filed with the SEC on March&nbsp;29,
  2000, including any amendments or reports filed for the purpose of
  updating that description.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;You may request a copy of these filings at no cost (other than exhibits unless those exhibits
  are specifically incorporated by reference herein) by writing or telephoning us at the following
  address:
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="20%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
      <TD width="62%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>Access Pharmaceuticals, Inc.</B></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>Attn: Investor Relations</B></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>2600 Stemmons Freeway, Suite&nbsp;176</B></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>Dallas, Texas 75207</B></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>(214)&nbsp;905-5100</B></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  <!-- link2 "Item&nbsp;4. Description of Securities" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;4. </B><B><I>Description of Securities</I></B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  
  <!-- link2 "Item&nbsp;5. Interests of Named Experts or Counsel" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;5. </B><B><I>Interests of Named Experts or Counsel</I></B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the securities registered hereby is being passed upon for us by Bingham
  McCutchen LLP 150 Federal Street, Boston, Massachusetts 02110. Several partners of Bingham
  McCutchen LLP, beneficially own shares of our common stock. John J. Concannon III, Esq. is our
  corporate Secretary.
  
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Item&nbsp;6. </B><B><I>Indemnification of Directors and Officers</I></B>.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the Delaware General Corporation Law (the &#147;DGCL&#148;) empowers a Delaware
  corporation to indemnify any person who was or is, or is threatened to be made, a party to any
  threatened, pending or completed action, suit or proceeding, whether civil, criminal,
  administrative or investigative (other than an action by or in the right of such corporation) by
  reason of the fact that such person is or was a director, officer, employee or agent of such
  corporation, or is or was serving at the request of such corporation as a director, officer,
  employee or agent of another corporation, partnership, joint venture, trust or other enterprise,
  provided that such person acted in good faith and in a manner that such person reasonably believed
  to be in or not opposed to the best interests of the corporation, and, with respect to any criminal
  action or proceeding, such person had no reasonable cause to believe his conduct was unlawful. The
  indemnity may include expenses (including attorneys&#146; fees), judgments, fines and amounts paid in
  settlement actually and reasonably incurred by such person in connection with such action, suit or
  proceeding. A Delaware corporation may also indemnify such persons against expenses (including
  attorneys&#146; fees) in actions brought by or in the right of the corporation to procure a judgment in
  its favor, subject to the same conditions set forth in the immediately preceding sentences, except
  that no indemnification is permitted in respect of any claim, issue or matter as to which such
  person
  
  
  
  
  
  
  
  <P align="center" style="font-size: 10pt">-2-
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <P align="left" style="font-size: 10pt">shall have been adjudged to be liable to the corporation unless and to the extent the Court of
  Chancery of the State of Delaware or the court in which such action or suit was brought shall
  determine upon application that, despite the adjudication of liability but in view of all the
  circumstances of the case, such person is fairly and reasonably entitled to indemnity for such
  expenses as the Court of Chancery or other such court shall deem proper. To the extent such person
  has been successful on the merits or otherwise in defense of any action to above, or in defense of
  any claim, issue or matter therein, the corporation must indemnify such person against expenses
  (including attorneys&#146; fees) actually and reasonably incurred by such person in connection
  therewith. The indemnification and advancement of expenses provided for in, or granted pursuant
  to, Section&nbsp;145 is not exclusive of any other rights to which those seeking indemnification or
  advancement of expenses may be entitled under any by-law, agreement, vote of stockholders or
  disinterested directors or otherwise.
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the DGCL also provides that a corporation may maintain insurance against
  liabilities for which indemnification is not expressly provided by the statute. The Registrant is
  insured against liabilities which it may incur by reason of its indemnification obligations under
  its Certificate of Incorporation, Bylaws and indemnification agreements.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Article&nbsp;X of the Registrant&#146;s Certificate of Incorporation provides that the Registrant will
  indemnify, defend and hold harmless directors, officers, employees and agents or the Registrant to
  the fullest extent currently permitted under the DGCL.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In addition, Article&nbsp;X of the Registrant&#146;s Certificate of Incorporation, provides that neither
  the Registrant nor its stockholders may recover monetary damages from the Registrant&#146;s directors
  for a breach of their fiduciary duty in the performance of their duties as directors of the
  Registrant, unless such breach relates to (i)&nbsp;the director&#146;s duty of loyalty, (ii)&nbsp;acts or
  omissions not in good faith or which involve intentional misconduct or a knowing violation of law,
  (iii)&nbsp;unlawful payments of dividends or unlawful stock repurchases or redemptions as provided in
  Section&nbsp;174 of the DGCL or (iv)&nbsp;any transactions for which the director derived an improper
  personal benefit. The By-Laws of the Registrant provide for indemnification of the Registrant&#146;s
  directors, officers, employees and agents on the terms permitted under Section&nbsp;145 of the DGCL
  described above.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant has entered into indemnification agreements with certain of its directors and
  executive officers. These agreements provide rights of indemnification to the full extent allowed
  and provided for by Section&nbsp;145 of the DGCL and the Certificate of Incorporation and Bylaws of
  Access.
  
  <!-- link2 "Item&nbsp;7. Exemption From Registration Claimed" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;7. </B><B><I>Exemption From Registration Claimed.</I></B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;8. </B><B><I>Exhibits</I></B><B>.</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following exhibits are filed as part of or incorporated by reference into this
  Registration Statement:
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.1&nbsp;&nbsp;</TD>
      <TD>Certificate of Incorporation (incorporated by reference to Exhibit 3(a) of the
  Registrant&#146;s Form 8-B dated July&nbsp;12, 1989, Commission File Number 9-9134)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.2&nbsp;&nbsp;</TD>
      <TD>Certificate of Amendment of Certificate of Incorporation filed August&nbsp;21, 1992</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.3&nbsp;&nbsp;</TD>
      <TD>Certificate of Merger filed January&nbsp;25, 1996 (incorporated by reference to
  Exhibit&nbsp;E of the Registrant&#146;s Registration Statement on Form S-4 dated December&nbsp;21,
  1995, Commission File No.&nbsp;33-64031)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.4&nbsp;&nbsp;</TD>
      <TD>Certificate of Amendment of Certificate of Incorporation filed January&nbsp;25, 1996
  (incorporated by reference to Exhibit&nbsp;E of the Registrant&#146;s Registration Statement on
  Form S-4 dated December&nbsp;21, 1995, Commission File No.&nbsp;33-64031)</TD>
  </TR>
  
  </TABLE>
  
  
  
  
  <P align="center" style="font-size: 10pt">-3-
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <P><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.5&nbsp;&nbsp;</TD>
      <TD>Certificate of Amendment of Certificate of Incorporation filed July&nbsp;18, 1996
  (incorporated by reference to Exhibit&nbsp;3.8 of the Registrant&#146;s Form 10-K for the year
  ended December&nbsp;31, 1996)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.6&nbsp;&nbsp;</TD>
      <TD>Certificate of Amendment of Certificate of Incorporation filed June&nbsp;18, 1998
  (incorporated by reference to Exhibit&nbsp;3.8 of the Registrant&#146;s Form 10-Q for the quarter
  ended June&nbsp;30, 1998)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.7&nbsp;&nbsp;</TD>
      <TD>Certificate of Amendment of Certificate of Incorporation filed July&nbsp;31, 2000
  (incorporated by reference to Exhibit&nbsp;3.8 of our form 10-Q for the quarter ended March
  31, 2001)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.8&nbsp;&nbsp;</TD>
      <TD>Amended and Restated Bylaws (incorporated by reference to Exhibit&nbsp;3.1 of the
  Registrant&#146;s Form 10-Q for the quarter ended June&nbsp;30, 1996)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.9&nbsp;&nbsp;</TD>
      <TD>Certificate of Designations of Series&nbsp;A Junior Participating Preferred Stock
  filed November&nbsp;7, 2001 (incorporated by reference to Exhibit&nbsp;4.1.h of our Registration
  Statement on Form S-8, dated December&nbsp;14, 2001, Commission File No.&nbsp;333-75136)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">3.10&nbsp;&nbsp;</TD>
      <TD>1995 Stock Option Plan (incorporated by reference to Exhibit&nbsp;F of our
  Registration Statement on Form S-4 dated December&nbsp;21, 1995, Commission File No.
  33-64031)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">4.1&nbsp;&nbsp;</TD>
      <TD>2000 Special Stock Option Plan and Agreement (incorporated by reference to
  Exhibit&nbsp;10.24 of our Form 10-Q for the quarter ended September&nbsp;30, 2000)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">4.3&nbsp;&nbsp;</TD>
      <TD>2001 Restricted Stock Plan (incorporated by reference to Exhibit&nbsp;2 of our Proxy
  Statement filed on April&nbsp;18, 2005)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">4.4&nbsp;&nbsp;</TD>
      <TD>2005 Equity Incentive Plan (incorporated by reference to Exhibit&nbsp;1 of our Proxy
  Statement filed on April&nbsp;18, 2005)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">4.5&nbsp;&nbsp;</TD>
      <TD>Form of 2005 Equity Incentive Plan Stock Option Agreement</TD>
  </TR>
  
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">4.6&nbsp;&nbsp;</TD>
      <TD>Form of 2005 Equity Incentive Plan Restricted Stock Grant Agreement</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">4.7&nbsp;&nbsp;</TD>
      <TD>Form of 1995 Stock Awards Grant</TD>
  
  </TR>
  
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">5&nbsp;&nbsp;</TD>
      <TD>Opinion of Bingham McCutchen LLP as to the legality of the securities being registered</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">23.1&nbsp;&nbsp;</TD>
      <TD>Consent of Grant Thornton LLP</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">23.2&nbsp;&nbsp;</TD>
      <TD>Consent of Bingham McCutchen LLP (included in Exhibit&nbsp;5)</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" style="background: transparent">&nbsp;</TD>
      <TD width="4%" nowrap align="left">24&nbsp;&nbsp;</TD>
      <TD>Power of Attorney (included on the signature page of this Registration Statement)</TD>
  </TR>
  
  </TABLE>
  
  <!-- link2 "Item&nbsp;9. Undertakings" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;9. </B><B><I>Undertakings.</I></B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant hereby undertakes:
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made pursuant
  to this Registration Statement, a post-effective amendment to this Registration
  Statement to include any material information with respect to the plan of
  distribution not previously disclosed in this Registration Statement or any material
  change to such information in this Registration Statement.
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act
  of 1933, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such
  securities at that time shall be deemed to be the initial <I>bona fide </I>offering
  thereof.
  
  
  
  <P align="left" style="margin-left:6%; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of
  the securities being registered which remain unsold at the termination of the
  offering.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the registrant&#146;s annual report pursuant to Section
  13(a) or 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit
  plan&#146;s annual
  
  
  <P align="center" style="font-size: 10pt">-4-
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <P align="left" style="font-size: 10pt">report pursuant to Section&nbsp;15(d) of the Securities Exchange Act of 1934) that is
  incorporated by reference in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such securities at that
  time shall be deemed to be the initial <I>bona fide </I>offering thereof.
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions described in Item&nbsp;6 above, or otherwise, the Registrant has been advised that
  in the opinion of the Securities and Exchange Commission such indemnification is against public
  policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a
  claim for indemnification against such liabilities (other than the payment by the Registrant of
  expenses incurred or paid by a director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such director, officer or
  controlling person in connection with the securities being registered, the Registrant will, unless
  in the opinion of its counsel the matter has been settled by controlling precedent, submit to a
  court of appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Securities Act and will be governed by the final adjudication of such
  issue.
  
  
  
  
  <P align="center" style="font-size: 10pt">-5-
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <!-- link1 " SIGNATURES" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <P align="center" style="font-size: 10pt">SIGNATURES
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
  the undersigned, thereunto duly authorized, in the City of Dallas, Texas, on
  this 14th day of June,
  2005.
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">ACCESS PHARMACEUTICALS, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">Date: June 14, 2005&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Rosemary Mazanet
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Rosemary Mazanet&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Acting Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">Date: June 14, 2005&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Stephen B. Thompson
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Stephen B. Thompson&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" align="left">Vice President, Chief Financial Officer and Treasurer</TD>
  
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <P align="center" style="font-size: 10pt">POWER OF ATTORNEY
  
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below hereby appoints Rosemary Mazanet, David Nowotnick,
  and Stephen B. Thompson, and each of them severally as his true and lawful attorney-in-fact with
  the authority to execute in the name of each such person, and to file with the Securities and
  Exchange Commission, together with any exhibits thereto and other documents therewith, any and all
  amendments (including without limitation post-effective amendments) to this Registration Statement
  on Form S-8 necessary or advisable to enable the Registrant to comply with the Securities Act of
  1933, as amended, and any rules, regulations, and requirements of the Securities and Exchange
  Commission in respect thereof, which amendments may make such other changes in the Registration
  Statement as the aforesaid attorney-in-fact executing the same deems appropriate.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration
  Statement has been signed by the following persons in the capacities and on the dates indicated.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="20%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Signature</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Title</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Date</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Rosemary Mazanet
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Acting Chief Executive,
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;14, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Officer and Director</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Rosemary Mazanet
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">(Principal Executive Officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Stephen B. Thompson
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Vice President, Chief
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;14, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Financial Officer, Treasurer</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Stephen B. Thompson
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">and Director (Principal</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Financial and Accounting Officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Stuart M. Duty
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;14, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Stuart M. Duty</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ J. Michael Flinn
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;14, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">J. Michael Flinn</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Stephen B. Howell
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;14, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Stephen B. Howell</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  <P align="center" style="font-size: 10pt">-6-
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="20%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Signature</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Title</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Date</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Max Link
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;14, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Max Link</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Herbert H. McDade, Jr.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;14, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Herbert H. McDade, Jr.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ John J. Meakem, Jr.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;14, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">John J. Meakem, Jr.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">-7-
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 " EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="009"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>EXHIBIT INDEX</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="90%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit No.</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000">Description of Documents</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Incorporation (incorporated by reference to Exhibit&nbsp;3(a) of the
  Registrant&#146;s Form&nbsp;8-B dated July&nbsp;12, 1989, Commission File Number 9-9134)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Certificate of Incorporation filed August&nbsp;21, 1992</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Merger filed January&nbsp;25, 1996 (incorporated by reference to
  Exhibit&nbsp;E of the Registrant&#146;s Registration Statement on Form&nbsp;S-4 dated December&nbsp;21,
  1995, Commission File No.&nbsp;33-64031)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Certificate of Incorporation filed January&nbsp;25, 1996
  (incorporated by reference to Exhibit&nbsp;E of the Registrant&#146;s Registration Statement on
  Form&nbsp;S-4 dated December&nbsp;21, 1995, Commission File No.&nbsp;33-64031)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Certificate of Incorporation filed July&nbsp;18, 1996
  (incorporated by reference to Exhibit&nbsp;3.8 of the Registrant&#146;s Form&nbsp;10-K for the year
  ended December&nbsp;31, 1996)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.6
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Certificate of Incorporation filed June&nbsp;18, 1998
  (incorporated by reference to Exhibit&nbsp;3.8 of the Registrant&#146;s Form&nbsp;10-Q for the quarter
  ended June&nbsp;30, 1998)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.7
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Certificate of Incorporation filed July&nbsp;31, 2000
  (incorporated by reference to Exhibit&nbsp;3.8 of our form 10-Q for the quarter ended March
  31, 2001)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.11
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated Bylaws (incorporated by reference to Exhibit&nbsp;3.1 of the
  Registrant&#146;s Form&nbsp;10-Q for the quarter ended June&nbsp;30, 1996)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.12
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Designations of Series&nbsp;A Junior Participating Preferred Stock
  filed November&nbsp;7, 2001 (incorporated by reference to Exhibit&nbsp;4.1.h of our Registration
  Statement on Form&nbsp;S-8, dated December&nbsp;14, 2001, Commission File No.&nbsp;333-75136)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">3.13
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">1995 Stock Option Plan (incorporated by reference to Exhibit&nbsp;F of our
  Registration Statement on Form&nbsp;S-4 dated December&nbsp;21, 1995, Commission File No.
  33-64031)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">2000 Special Stock Option Plan and Agreement (incorporated by reference to
  Exhibit&nbsp;10.24 of our Form&nbsp;10-Q for the quarter ended September&nbsp;30, 2000)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">2001 Restricted Stock Plan (incorporated by reference to Exhibit&nbsp;2 of our Proxy
  Statement filed on April&nbsp;18, 2005)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">2005 Equity Incentive Plan (incorporated by reference to Exhibit&nbsp;1 of our Proxy
  Statement filed on April&nbsp;18, 2005)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of 2005 Equity Incentive Plan Stock Option Agreement</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.6
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of 2005 Equity Incentive Plan
  Restricted Stock Grant Agreement</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.7
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of 1995 Stock Awards Grant</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Bingham McCutchen LLP as to the legality of the securities being registered</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Grant Thornton LLP</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Bingham McCutchen LLP (included in Exhibit&nbsp;5)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included on the signature page of this Registration Statement)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  </BODY>
  </HTML>
metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "b55431apsv8.htm", "description": "ACCESS PHARMACEUTICALS FORM S-8", "secsgml_size_bytes": 61217}]
metadata_filer: {"company-data": {"conformed-name": "ACCESS PHARMACEUTICALS INC", "cik": "0000318306", "assigned-sic": "2834", "irs-number": "830221517", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-125796", "film-number": "05894559"}, "business-address": {"street1": "2600 N STEMMONS FRWY", "street2": "STE 176", "city": "DALLAS", "state": "TX", "zip": "75207", "phone": "2149055100"}, "mail-address": {"street1": "2600 N STEMMONS FRWY", "street2": "STE 176", "city": "DALLAS", "state": "TX", "zip": "75207"}, "former-company": [{"former-conformed-name": "CHEMEX PHARMACEUTICALS INC", "date-changed": "19920703"}, {"former-conformed-name": "CHEMEX CORP/WY", "date-changed": "19831102"}]}
text: sv8
  Table of Contents
  As filed with the
  Securities and Exchange Commission on June 14, 2005
  File No. 333-______
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, DC 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  ACCESS
  PHARMACEUTICALS, INC.
  (Exact Name of Registrant as Specified in Its Charter)
  DELAWARE
  83-0221517
  (State or Other Jurisdiction of Incorporation or
  (I.R.S. Employer
  Organization)
  Identification No.)
  2600 Stemmons Freeway, Suite 176
  Dallas, Texas 75207
  (Address of Principal Executive Offices) (Zip Code)
  ACCESS PHARMACEUTICALS, INC.
  2005 EQUITY INCENTIVE PLAN
  2001 RESTRICTED STOCK PLAN
  (Full Title of the Plan)
  Stephen B. Thompson
  Chief Financial Officer
  Access Pharmaceuticals, Inc.
  2600 Stemmons Freeway, Suite 176
  Dallas, Texas 75207
  (Name and Address of Agent For Service)
  (214) 905-5100
  Telephone Number, Including Area Code, of Agent for Service
  Copies to:
  John J. Concannon III, Esq.
  Bingham McCutchen LLP
  150 Federal Street
  Boston, MA 02110-1726
  (617) 951-8000
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  Amount
  Maximum
  Maximum
  Amount Of
  Title Of
  To Be
  Offering Price
  Aggregate
  Registration
  Securities To Be Registered
  Registered
  Per Share
  Offering Price
  (1)
  Fee
  Common Stock,
  $0.01 par value
  900,000
  $
  2.20
  (1)
  $
  1,980,000
  $
  233.05
  (1)
  Estimated solely for purposes of computing the registration fee pursuant to Rule
  457(h) under the Securities Act of 1933, as amended, based on the average of the high
  and low prices of the Registrant's Common Stock, $0.01 par value per share, reported
  by the American Stock Exchange on June 9, 2005.
  TABLE OF CONTENTS
  PART II
  Item 3. Incorporation of Documents by Reference
  Item 4. Description of Securities
  Item 5. Interests of Named Experts or Counsel
  Item 6. Indemnification of Directors and Officers
  Item 7. Exemption From Registration Claimed
  Item 8. Exhibits
  Item 9. Undertakings
  SIGNATURES
  EXHIBIT INDEX
  EX-4.5 FORM OF 2005 EQUITY INCENTIVE PLAN STOCK OPTION AGREEMENT
  EX-4.6 FORM OF 2005 EQUITY INCENTIVE PLAN RESTRICTED STOCK GRANT AGREEMENT
  EX-4.7 FORM OF 1995 STOCK AWARDS GRANT
  EX-5 OPINION OF BINGHAM MCCUTCHEN LLP
  EX-23.1 CONSENT OF GRANT THORNTON LLP
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference.
  Access Pharmaceuticals, Inc. (the "Registrant") incorporates by reference the documents listed
  below and any future filings the Registrant will make with the SEC under Section 13(a), 13(c), 14
  or 15(d) of the Securities Exchange Act of 1934, as amended:
  --
  Annual Report on Form 10-K for the year ended December 31, 2004;
  --
  Quarterly Report on Form 10-Q for the quarter ended March 31, 2005;
  --
  Current Reports on Form 8-K filed on January 31, 2005, March 16, 2005,
  April 1, 2005, May 4, 2005 and May 16, 2005; and
  --
  the description of the Registrant's common stock contained in its
  registration statement on Form 8-A filed with the SEC on March 29,
  2000, including any amendments or reports filed for the purpose of
  updating that description.
  You may request a copy of these filings at no cost (other than exhibits unless those exhibits
  are specifically incorporated by reference herein) by writing or telephoning us at the following
  address:
  Access Pharmaceuticals, Inc.
  Attn: Investor Relations
  2600 Stemmons Freeway, Suite 176
  Dallas, Texas 75207
  (214) 905-5100
  Item 4.
  Description of Securities
  Not applicable.
  Item 5.
  Interests of Named Experts or Counsel
  The validity of the securities registered hereby is being passed upon for us by Bingham
  McCutchen LLP 150 Federal Street, Boston, Massachusetts 02110. Several partners of Bingham
  McCutchen LLP, beneficially own shares of our common stock. John J. Concannon III, Esq. is our
  corporate Secretary.
  Item 6.
  Indemnification of Directors and Officers
  .
  Section 145 of the Delaware General Corporation Law (the "DGCL") empowers a Delaware
  corporation to indemnify any person who was or is, or is threatened to be made, a party to any
  threatened, pending or completed action, suit or proceeding, whether civil, criminal,
  administrative or investigative (other than an action by or in the right of such corporation) by
  reason of the fact that such person is or was a director, officer, employee or agent of such
  corporation, or is or was serving at the request of such corporation as a director, officer,
  employee or agent of another corporation, partnership, joint venture, trust or other enterprise,
  provided that such person acted in good faith and in a manner that such person reasonably believed
  to be in or not opposed to the best interests of the corporation, and, with respect to any criminal
  action or proceeding, such person had no reasonable cause to believe his conduct was unlawful. The
  indemnity may include expenses (including attorneys' fees), judgments, fines and amounts paid in
  settlement actually and reasonably incurred by such person in connection with such action, suit or
  proceeding. A Delaware corporation may also indemnify such persons against expenses (including
  attorneys' fees) in actions brought by or in the right of the corporation to procure a judgment in
  its favor, subject to the same conditions set forth in the immediately preceding sentences, except
  that no indemnification is permitted in respect of any claim, issue or matter as to which such
  person
  -2-
  Table of Contents
  shall have been adjudged to be liable to the corporation unless and to the extent the Court of
  Chancery of the State of Delaware or the court in which such action or suit was brought shall
  determine upon application that, despite the adjudication of liability but in view of all the
  circumstances of the case, such person is fairly and reasonably entitled to indemnity for such
  expenses as the Court of Chancery or other such court shall deem proper. To the extent such person
  has been successful on the merits or otherwise in defense of any action to above, or in defense of
  any claim, issue or matter therein, the corporation must indemnify such person against expenses
  (including attorneys' fees) actually and reasonably incurred by such person in connection
  therewith. The indemnification and advancement of expenses provided for in, or granted pursuant
  to, Section 145 is not exclusive of any other rights to which those seeking indemnification or
  advancement of expenses may be entitled under any by-law, agreement, vote of stockholders or
  disinterested directors or otherwise.
  Section 145 of the DGCL also provides that a corporation may maintain insurance against
  liabilities for which indemnification is not expressly provided by the statute. The Registrant is
  insured against liabilities which it may incur by reason of its indemnification obligations under
  its Certificate of Incorporation, Bylaws and indemnification agreements.
  Article X of the Registrant's Certificate of Incorporation provides that the Registrant will
  indemnify, defend and hold harmless directors, officers, employees and agents or the Registrant to
  the fullest extent currently permitted under the DGCL.
  In addition, Article X of the Registrant's Certificate of Incorporation, provides that neither
  the Registrant nor its stockholders may recover monetary damages from the Registrant's directors
  for a breach of their fiduciary duty in the performance of their duties as directors of the
  Registrant, unless such breach relates to (i) the director's duty of loyalty, (ii) acts or
  omissions not in good faith or which involve intentional misconduct or a knowing violation of law,
  (iii) unlawful payments of dividends or unlawful stock repurchases or redemptions as provided in
  Section 174 of the DGCL or (iv) any transactions for which the director derived an improper
  personal benefit. The By-Laws of the Registrant provide for indemnification of the Registrant's
  directors, officers, employees and agents on the terms permitted under Section 145 of the DGCL
  described above.
  The Registrant has entered into indemnification agreements with certain of its directors and
  executive officers. These agreements provide rights of indemnification to the full extent allowed
  and provided for by Section 145 of the DGCL and the Certificate of Incorporation and Bylaws of
  Access.
  Item 7.
  Exemption From Registration Claimed.
  Not applicable.
  Item 8.
  Exhibits
  .
  The following exhibits are filed as part of or incorporated by reference into this
  Registration Statement:
  3.1
  Certificate of Incorporation (incorporated by reference to Exhibit 3(a) of the
  Registrant's Form 8-B dated July 12, 1989, Commission File Number 9-9134)
  3.2
  Certificate of Amendment of Certificate of Incorporation filed August 21, 1992
  3.3
  Certificate of Merger filed January 25, 1996 (incorporated by reference to
  Exhibit E of the Registrant's Registration Statement on Form S-4 dated December 21,
  1995, Commission File No. 33-64031)
  3.4
  Certificate of Amendment of Certificate of Incorporation filed January 25, 1996
  (incorporated by reference to Exhibit E of the Registrant's Registration Statement on
  Form S-4 dated December 21, 1995, Commission File No. 33-64031)
  -3-
  Table of Contents
  3.5
  Certificate of Amendment of Certificate of Incorporation filed July 18, 1996
  (incorporated by reference to Exhibit 3.8 of the Registrant's Form 10-K for the year
  ended December 31, 1996)
  3.6
  Certificate of Amendment of Certificate of Incorporation filed June 18, 1998
  (incorporated by reference to Exhibit 3.8 of the Registrant's Form 10-Q for the quarter
  ended June 30, 1998)
  3.7
  Certificate of Amendment of Certificate of Incorporation filed July 31, 2000
  (incorporated by reference to Exhibit 3.8 of our form 10-Q for the quarter ended March
  31, 2001)
  3.8
  Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 of the
  Registrant's Form 10-Q for the quarter ended June 30, 1996)
  3.9
  Certificate of Designations of Series A Junior Participating Preferred Stock
  filed November 7, 2001 (incorporated by reference to Exhibit 4.1.h of our Registration
  Statement on Form S-8, dated December 14, 2001, Commission File No. 333-75136)
  3.10
  1995 Stock Option Plan (incorporated by reference to Exhibit F of our
  Registration Statement on Form S-4 dated December 21, 1995, Commission File No.
  33-64031)
  4.1
  2000 Special Stock Option Plan and Agreement (incorporated by reference to
  Exhibit 10.24 of our Form 10-Q for the quarter ended September 30, 2000)
  4.3
  2001 Restricted Stock Plan (incorporated by reference to Exhibit 2 of our Proxy
  Statement filed on April 18, 2005)
  4.4
  2005 Equity Incentive Plan (incorporated by reference to Exhibit 1 of our Proxy
  Statement filed on April 18, 2005)
  4.5
  Form of 2005 Equity Incentive Plan Stock Option Agreement
  4.6
  Form of 2005 Equity Incentive Plan Restricted Stock Grant Agreement
  4.7
  Form of 1995 Stock Awards Grant
  5
  Opinion of Bingham McCutchen LLP as to the legality of the securities being registered
  23.1
  Consent of Grant Thornton LLP
  23.2
  Consent of Bingham McCutchen LLP (included in Exhibit 5)
  24
  Power of Attorney (included on the signature page of this Registration Statement)
  Item 9.
  Undertakings.
  The Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made pursuant
  to this Registration Statement, a post-effective amendment to this Registration
  Statement to include any material information with respect to the plan of
  distribution not previously disclosed in this Registration Statement or any material
  change to such information in this Registration Statement.
  (2) That, for the purpose of determining any liability under the Securities Act
  of 1933, each such post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such
  securities at that time shall be deemed to be the initial
  bona fide
  offering
  thereof.
  (3) To remove from registration by means of a post-effective amendment any of
  the securities being registered which remain unsold at the termination of the
  offering.
  The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the registrant's annual report pursuant to Section
  13(a) or 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit
  plan's annual
  -4-
  Table of Contents
  report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is
  incorporated by reference in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of such securities at that
  time shall be deemed to be the initial
  bona fide
  offering thereof.
  Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions described in Item 6 above, or otherwise, the Registrant has been advised that
  in the opinion of the Securities and Exchange Commission such indemnification is against public
  policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a
  claim for indemnification against such liabilities (other than the payment by the Registrant of
  expenses incurred or paid by a director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such director, officer or
  controlling person in connection with the securities being registered, the Registrant will, unless
  in the opinion of its counsel the matter has been settled by controlling precedent, submit to a
  court of appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Securities Act and will be governed by the final adjudication of such
  issue.
  -5-
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
  the undersigned, thereunto duly authorized, in the City of Dallas, Texas, on
  this 14th day of June,
  2005.
  ACCESS PHARMACEUTICALS, INC.
  Date: June 14, 2005
  By:
  /s/ Rosemary Mazanet
  Rosemary Mazanet
  Acting Chief Executive Officer
  Date: June 14, 2005
  By:
  /s/ Stephen B. Thompson
  Stephen B. Thompson
  Vice President, Chief Financial Officer and Treasurer
  POWER OF ATTORNEY
  Each person whose signature appears below hereby appoints Rosemary Mazanet, David Nowotnick,
  and Stephen B. Thompson, and each of them severally as his true and lawful attorney-in-fact with
  the authority to execute in the name of each such person, and to file with the Securities and
  Exchange Commission, together with any exhibits thereto and other documents therewith, any and all
  amendments (including without limitation post-effective amendments) to this Registration Statement
  on Form S-8 necessary or advisable to enable the Registrant to comply with the Securities Act of
  1933, as amended, and any rules, regulations, and requirements of the Securities and Exchange
  Commission in respect thereof, which amendments may make such other changes in the Registration
  Statement as the aforesaid attorney-in-fact executing the same deems appropriate.
  Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration
  Statement has been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Rosemary Mazanet
  Acting Chief Executive,
  June 14, 2005
  Officer and Director
  Rosemary Mazanet
  (Principal Executive Officer)
  /s/ Stephen B. Thompson
  Vice President, Chief
  June 14, 2005
  Financial Officer, Treasurer
  Stephen B. Thompson
  and Director (Principal
  Financial and Accounting Officer)
  /s/ Stuart M. Duty
  Director
  June 14, 2005
  Stuart M. Duty
  /s/ J. Michael Flinn
  Director
  June 14, 2005
  J. Michael Flinn
  /s/ Stephen B. Howell
  Director
  June 14, 2005
  Stephen B. Howell
  -6-
  Table of Contents
  Signature
  Title
  Date
  /s/ Max Link
  Director
  June 14, 2005
  Max Link
  /s/ Herbert H. McDade, Jr.
  Director
  June 14, 2005
  Herbert H. McDade, Jr.
  /s/ John J. Meakem, Jr.
  Director
  June 14, 2005
  John J. Meakem, Jr.
  -7-
  Table of Contents
  EXHIBIT INDEX
  Exhibit No.
  Description of Documents
  3.1
  Certificate of Incorporation (incorporated by reference to Exhibit 3(a) of the
  Registrant's Form 8-B dated July 12, 1989, Commission File Number 9-9134)
  3.2
  Certificate of Amendment of Certificate of Incorporation filed August 21, 1992
  3.3
  Certificate of Merger filed January 25, 1996 (incorporated by reference to
  Exhibit E of the Registrant's Registration Statement on Form S-4 dated December 21,
  1995, Commission File No. 33-64031)
  3.4
  Certificate of Amendment of Certificate of Incorporation filed January 25, 1996
  (incorporated by reference to Exhibit E of the Registrant's Registration Statement on
  Form S-4 dated December 21, 1995, Commission File No. 33-64031)
  3.5
  Certificate of Amendment of Certificate of Incorporation filed July 18, 1996
  (incorporated by reference to Exhibit 3.8 of the Registrant's Form 10-K for the year
  ended December 31, 1996)
  3.6
  Certificate of Amendment of Certificate of Incorporation filed June 18, 1998
  (incorporated by reference to Exhibit 3.8 of the Registrant's Form 10-Q for the quarter
  ended June 30, 1998)
  3.7
  Certificate of Amendment of Certificate of Incorporation filed July 31, 2000
  (incorporated by reference to Exhibit 3.8 of our form 10-Q for the quarter ended March
  31, 2001)
  3.11
  Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 of the
  Registrant's Form 10-Q for the quarter ended June 30, 1996)
  3.12
  Certificate of Designations of Series A Junior Participating Preferred Stock
  filed November 7, 2001 (incorporated by reference to Exhibit 4.1.h of our Registration
  Statement on Form S-8, dated December 14, 2001, Commission File No. 333-75136)
  3.13
  1995 Stock Option Plan (incorporated by reference to Exhibit F of our
  Registration Statement on Form S-4 dated December 21, 1995, Commission File No.
  33-64031)
  4.2
  2000 Special Stock Option Plan and Agreement (incorporated by reference to
  Exhibit 10.24 of our Form 10-Q for the quarter ended September 30, 2000)
  4.3
  2001 Restricted Stock Plan (incorporated by reference to Exhibit 2 of our Proxy
  Statement filed on April 18, 2005)
  4.4
  2005 Equity Incentive Plan (incorporated by reference to Exhibit 1 of our Proxy
  Statement filed on April 18, 2005)
  4.5
  Form of 2005 Equity Incentive Plan Stock Option Agreement
  4.6
  Form of 2005 Equity Incentive Plan
  Restricted Stock Grant Agreement
  4.7
  Form of 1995 Stock Awards Grant
  5
  Opinion of Bingham McCutchen LLP as to the legality of the securities being registered
  23.1
  Consent of Grant Thornton LLP
  23.2
  Consent of Bingham McCutchen LLP (included in Exhibit 5)
  24
  Power of Attorney (included on the signature page of this Registration Statement)