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  <TITLE>ANTIGENICS, INC.</TITLE>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <P align="center" style="font-size: 10pt">As filed with the
  Securities and Exchange Commission on May&nbsp;28, 2004
  
  
  
  <P align="right" style="font-size: 10pt">Registration
  No.&nbsp;333-<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
  
  <P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">
  
  
  
  
  
  <P align="center" style="font-size: 18pt"><B>FORM S-8</B>
  
  
  <P align="center" style="font-size: 10pt">REGISTRATION STATEMENT<BR>
  UNDER<BR>
  THE SECURITIES ACT OF 1933
  
  
  
  <P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">
  
  
  <P align="center" style="font-size: 24pt"><B>ANTIGENICS INC.</B>
  
  <DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  
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  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>06-1562417</B></TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top">State or other jurisdiction<BR>
  of incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer<BR>
  Identification No.)</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">Antigenics Inc.<BR>
  630 Fifth Avenue, Suite&nbsp;2100<BR>
  New York, NY 10111<BR>
  (Address of principal executive offices, including zip code)
  
  
  
  <P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">
  
  
  
  <P align="center" style="font-size: 10pt"><B>1999 EQUITY INCENTIVE PLAN</B><BR>
  (Full title of the plan)
  
  
  
  <P align="center" style="font-size: 10pt">Garo H. Armen<BR>
  Antigenics Inc.<BR>
  630 Fifth Avenue, Suite&nbsp;2100<BR>
  New York, NY 10111<BR>
  212-994-8200<BR>
  (Name, address and telephone number, including area code, of agent for service)
  
  
  
  <P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">
  
  
  
  <P align="center" style="font-size: 10pt">Please send copies of all communications to:<BR>
  Paul M. Kinsella<BR>
  Ropes &#038; Gray LLP<BR>
  One International Place<BR>
  Boston, MA 02110<BR>
  617-951-7000<BR>
  617-951-7050 (facsimile)
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="29%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="14%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="14%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Title of Each Class</B></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>of Securities to be</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount to be</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Offering Price Per</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Aggregate Offering</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Registered</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Registered</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Share(1)</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Price(1)</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Registration Fee</B><HR size="1" noshade></TD>
  </TR>
  
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD><DIV style="margin-left:10px; text-indent:-10px">Common Stock, $0.01
  par value per share</DIV></TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" align="center">4,000,000 shares(2)</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">8.35</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">33,400,000.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">4,231.78</TD>
      <TD>&nbsp;</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" nowrap align="right">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Pursuant to Rules 457(c) and 457(h)(1) under the Securities Act of 1933,
  the proposed maximum offering price per share and the maximum aggregate
  offering price for the shares have been calculated solely for the purpose
  of computing the registration fee on the basis of the average high and low
  prices of the Common Stock as reported by the Nasdaq National Market on
  May&nbsp;24, 2004 to be $8.60 and $8.09, respectively.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" nowrap align="right">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Pursuant to Rule 416(a) under the Securities Act of 1933, this registration
  statement also covers such additional shares of Common Stock as may be issued
  to prevent dilution from stock splits, stock dividends and similar
  transactions.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
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  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000"> SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b50690s8exv5w1.txt">OPINION OF ROPES & GRAY LLP.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b50690s8exv10w1.txt">AMENDMENT #2 TO 1999 EQUITY INCENTIVE PLAN</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b50690s8exv23w1.txt">CONSENT OF KPMG LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  
  
  <P align="center" style="font-size: 10pt">Explanatory Note
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
  Registrant hereby increases the number of shares of its Common Stock
  available for issuance under the 1999 Equity Incentive Plan &#040;the
  &#147;Plan&#148;&#041; by 4 million shares so that a total of 10 million shares
  will be available under the Plan. Pursuant to Instruction&nbsp;E to
  Form&nbsp;S-8, the Registrant incorporates by reference into this
  Registration Statement the
  entire contents of its Registration Statement on Form S-8 &#040;File
  No. 333-40442&#041; filed with the Securities and Exchange Commission
  on June 29, 2000 and amended on June 11, 2003.
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 " SIGNATURES" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>SIGNATURES</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of New York, State of New York, on this 28th day of
  May, 2004.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="48%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="46%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" valign="top" align="left">ANTIGENICS INC.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By:</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">/s/ Garo H. Armen</TD>
  </TR>
  
  <TR style="font-size: 1px">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><HR size="1" noshade>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Name: Garo H. Armen<br>
  Title: Chief Executive Officer</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Garo
  H. Armen his true and lawful attorney-in-fact and agent, with full power of
  substitution and resubstitution, severally, for him and in his name, place and
  stead, in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement, and to file the
  same, with all exhibits thereto and other documents in connection therewith,
  with the Securities and Exchange Commission, granting unto said
  attorney-in-fact and agent full power and authority to do and perform each
  and every act and thing requisite and necessary to be done, as fully to all
  intents and purposes as he might or could do in person, hereby ratifying and
  confirming all that said attorney-in-fact and agent or his substitute or
  substitutes, may lawfully do or cause to be done by virtue hereof.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933,
  this Registration Statement has been signed by the following persons in the
  capacities indicated and on May&nbsp;28, 2004.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="40%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="42%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Title</B></TD>
  </TR>
  
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
  
  <TD valign="bottom"><DIV style="margin-left:0px; text-indent:-0px">/s/
  Garo H. Armen, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chief Executive Officer and Chairman of the
  Board of Directors<br>
  (Principal Executive Officer, Principal</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade>
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Financial Officer, and Principal Accounting</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Garo H. Armen, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Officer)</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/
  Noubar Afeyan, Ph.D.<HR size="1" noshade></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Noubar Afeyan, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/
  Frank AtLee<HR size="1" noshade></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Frank AtLee
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/
  Gamil de Chadarevian<HR size="1" noshade></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Gamil de Chadarevian
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director, Vice Chairman of the Board</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="40%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="42%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Tom Dechaene<HR size="1" noshade></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Tom Dechaene
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Margaret Eisen<HR size="1" noshade></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Margaret Eisen
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Wadih Jordan<HR size="1" noshade></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Wadih Jordan
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Mark Kessel<HR size="1" noshade></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Mark Kessel
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Pramod Srivastava<HR size="1" noshade></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Pramod Srivastava
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <P align="center" style="font-size: 10pt"><B>EXHIBIT INDEX</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  
  <!-- Begin Table Head --><TR valign="bottom">
      <TD width="5%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="93%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Ropes &#038; Gray LLP.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">10.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Antigenics Inc. Amendment No.&nbsp;2 to 1999 Equity Incentive Plan.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of KPMG LLP.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ropes &#038; Gray LLP (included in the opinion filed as Exhibit&nbsp;5.1).</TD>
  </TR>
  
  
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text: ANTIGENICS, INC.
  Table of Contents
  As filed with the
  Securities and Exchange Commission on May 28, 2004
  Registration
  No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  ANTIGENICS INC.
  (Exact name of registrant as specified in its charter)
  Delaware
  06-1562417
  State or other jurisdiction
  of incorporation or organization)
  (I.R.S. Employer
  Identification No.)
  Antigenics Inc.
  630 Fifth Avenue, Suite 2100
  New York, NY 10111
  (Address of principal executive offices, including zip code)
  1999 EQUITY INCENTIVE PLAN
  (Full title of the plan)
  Garo H. Armen
  Antigenics Inc.
  630 Fifth Avenue, Suite 2100
  New York, NY 10111
  212-994-8200
  (Name, address and telephone number, including area code, of agent for service)
  Please send copies of all communications to:
  Paul M. Kinsella
  Ropes & Gray LLP
  One International Place
  Boston, MA 02110
  617-951-7000
  617-951-7050 (facsimile)
  Title of Each Class
  Proposed Maximum
  Proposed Maximum
  of Securities to be
  Amount to be
  Offering Price Per
  Aggregate Offering
  Amount of
  Registered
  Registered
  Share(1)
  Price(1)
  Registration Fee
  Common Stock, $0.01
  par value per share
  4,000,000 shares(2)
  $
  8.35
  $
  33,400,000.00
  $
  4,231.78
  (1)
  Pursuant to Rules 457(c) and 457(h)(1) under the Securities Act of 1933,
  the proposed maximum offering price per share and the maximum aggregate
  offering price for the shares have been calculated solely for the purpose
  of computing the registration fee on the basis of the average high and low
  prices of the Common Stock as reported by the Nasdaq National Market on
  May 24, 2004 to be $8.60 and $8.09, respectively.
  (2)
  Pursuant to Rule 416(a) under the Securities Act of 1933, this registration
  statement also covers such additional shares of Common Stock as may be issued
  to prevent dilution from stock splits, stock dividends and similar
  transactions.
  TABLE OF CONTENTS
  SIGNATURES
  OPINION OF ROPES & GRAY LLP.
  AMENDMENT #2 TO 1999 EQUITY INCENTIVE PLAN
  CONSENT OF KPMG LLP
  Table of Contents
  Explanatory Note
  The
  Registrant hereby increases the number of shares of its Common Stock
  available for issuance under the 1999 Equity Incentive Plan (the
  "Plan") by 4 million shares so that a total of 10 million shares
  will be available under the Plan. Pursuant to Instruction E to
  Form S-8, the Registrant incorporates by reference into this
  Registration Statement the
  entire contents of its Registration Statement on Form S-8 (File
  No. 333-40442) filed with the Securities and Exchange Commission
  on June 29, 2000 and amended on June 11, 2003.
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of New York, State of New York, on this 28th day of
  May, 2004.
  ANTIGENICS INC.
  By:
  /s/ Garo H. Armen
  Name: Garo H. Armen
  Title: Chief Executive Officer
  Each person whose signature appears below constitutes and appoints Garo
  H. Armen his true and lawful attorney-in-fact and agent, with full power of
  substitution and resubstitution, severally, for him and in his name, place and
  stead, in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement, and to file the
  same, with all exhibits thereto and other documents in connection therewith,
  with the Securities and Exchange Commission, granting unto said
  attorney-in-fact and agent full power and authority to do and perform each
  and every act and thing requisite and necessary to be done, as fully to all
  intents and purposes as he might or could do in person, hereby ratifying and
  confirming all that said attorney-in-fact and agent or his substitute or
  substitutes, may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933,
  this Registration Statement has been signed by the following persons in the
  capacities indicated and on May 28, 2004.
  Signature
  Title
  /s/
  Garo H. Armen, Ph.D.
  Chief Executive Officer and Chairman of the
  Board of Directors
  (Principal Executive Officer, Principal
  Financial Officer, and Principal Accounting
  Garo H. Armen, Ph.D.
  Officer)
  /s/
  Noubar Afeyan, Ph.D.
  Noubar Afeyan, Ph.D.
  Director
  /s/
  Frank AtLee
  Frank AtLee
  Director
  /s/
  Gamil de Chadarevian
  Gamil de Chadarevian
  Director, Vice Chairman of the Board
  Table of Contents
  /s/ Tom Dechaene
  Tom Dechaene
  Director
  /s/ Margaret Eisen
  Margaret Eisen
  Director
  /s/ Wadih Jordan
  Wadih Jordan
  Director
  /s/ Mark Kessel
  Mark Kessel
  Director
  /s/ Pramod Srivastava
  Pramod Srivastava
  Director
  Table of Contents
  EXHIBIT INDEX
  5.1
  Opinion of Ropes & Gray LLP.
  10.1
  Antigenics Inc. Amendment No. 2 to 1999 Equity Incentive Plan.
  23.1
  Consent of KPMG LLP.
  23.2
  Consent of Ropes & Gray LLP (included in the opinion filed as Exhibit 5.1).