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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P align="center" style="font-size: 10pt"><B>As filed with the
  Securities and Exchange Commission on June&nbsp;30, 2004</B>
  
  
  
  <P align="right" style="font-size: 10pt"><B>REGISTRATION NO. 333-</B>
  
  
  
  <HR size="4" noshade color="#000000" style="margin-top: -5px">
  <HR size="1" noshade color="#000000" style="margin-top: -10px">
  
  
  
  
  
  
  
  <P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B><HR size="1" noshade width="40%" align="center"></B>
  </DIV>
  
  <P align="center" style="font-size: 18pt"><B>FORM S-8</B>
  
  <DIV align="center" style="font-size: 12pt"><B>REGISTRATION STATEMENT</B></DIV>
  
  
  <DIV align="center" style="font-size: 13pt"><B>under the</B></DIV>
  
  
  <DIV align="center" style="font-size: 12pt"><B>SECURITIES ACT OF 1933</B></DIV>
  
  
  <DIV align="center" style="font-size: 10pt"><HR size="1" noshade width="40%" align="center"></DIV>
  
  
  <P align="center" style="font-size: 24pt"><B>ARIAD PHARMACEUTICALS, INC.</B>
  
  <DIV align="center" style="font-size: 10pt"><I>(Exact name of Registrant as specified in its charter)</I></DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="55%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B><BR>
  (<I>State or other jurisdiction<BR>
  of incorporation or organization</I>)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>22-3106987</B><BR>
  (<I>I.R.S. Employer<BR>
  Identification No.</I>)</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt"><B>26 Landsdowne Street<BR>
  Cambridge, Massachusetts 02139<BR>
  (617)&nbsp;494-0400</B><BR>
  <I>(Address of Principal Executive Offices)</I>
  
  
  
  <P align="center" style="font-size: 10pt"><B>ARIAD PHARMACEUTICALS, INC.<BR>
  2001 STOCK PLAN, AS AMENDED</B>
  
  
  
  <P align="center" style="font-size: 10pt"><B>NON-QUALIFIED STOCK OPTION AGREEMENT,<BR>
  DATED OCTOBER 1, 2003, ISSUED TO PAUL J. SEKHRI</B>
  
  
  
  <P align="center" style="font-size: 10pt"><B>Harvey J. Berger, M.D.<BR>
  Chairman and Chief Executive Officer<BR>
  ARIAD Pharmaceuticals, Inc.<BR>
  26 Landsdowne Street<BR>
  Cambridge, Massachusetts 02139-4234<BR>
  (617)&nbsp;494-0400</B><BR>
  <I>(Name, address, including zip code, and telephone number, including area<BR>
  code, of agent for service)</I>
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  <P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="37%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="6%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="6%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B> Title of</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount to be</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Offering Price</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Aggregate</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B> Securities to be Registered</B><HR noshade size="1"></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Registered<SUP>(1)</SUP></B><HR noshade size="1"></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Per Share <SUP>(2)</SUP></B><HR noshade size="1"></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Offering Price<SUP>(2)</SUP></B><HR noshade size="1"></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3"><B>Registration Fee</B><HR noshade size="1"></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD><DIV style="margin-left:10px; text-indent:-10px">Common Stock, $.001 par</DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">2,807,924</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">7.33</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">20,582,083</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">2,607.75</TD>
      <TD>&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD><DIV style="margin-left:10px; text-indent:-10px">value <SUP>(3)</SUP>
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">192,076</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">7.44</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">1,429,045</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">181.06</TD>
      <TD>&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD><DIV style="margin-left:10px; text-indent:-10px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">135,000</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">6.51</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">878,850</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">111.35</TD>
      <TD>&nbsp;</TD>
  </TR>
  
  <TR style="font-size: 1px">
      <TD><DIV style="margin-left:10px; text-indent:-10px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right"><HR size="1" noshade>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right"><HR size="1" noshade>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD><DIV style="margin-left:10px; text-indent:-10px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">3,135,000</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">$</TD>
      <TD align="right">2,900.16</TD>
      <TD>&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The number of shares of common stock, par value $.001 per share
  (&#147;Common Stock&#148;), stated above consists of (i)&nbsp;an aggregate of
  3,000,000 additional shares not previously registered, which may be
  sold upon the exercise of options which have been granted (192,076
  shares) or upon the exercise of options or issuance of stock awards
  which may hereafter be granted (2,807,924 shares) under the ARIAD
  Pharmaceuticals, Inc. 2001 Stock Plan, as amended (the &#147;Plan&#148;) and (ii)
  an aggregate of 135,000 shares, which may be sold upon the exercise of
  options granted under that certain Non-Qualified Stock Option
  Agreement, dated October&nbsp;1, 2003, issued to Paul J. Sekhri (the &#147;Sekhri
  Option Agreement&#148;). The maximum number of shares which may be sold upon
  the exercise of such options or issuance of stock awards granted under
  the Plan and the Sekhri Option Agreement is subject to adjustment in
  accordance with certain anti-dilution and other provisions of the Plan
  and the Sekhri Option Agreement. Accordingly, pursuant to Rule&nbsp;416
  under the Securities Act of 1933, as amended (the &#147;Securities Act&#148;),
  this Registration Statement covers, in addition to the number of shares
  stated above, an indeterminate number of shares which may be subject to
  grant or otherwise issuable after the operation of any such
  anti-dilution and other provisions.</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>This calculation is made solely for the purpose of determining the
  registration fee pursuant to the provisions of Rule 457(c) and (h)
  under the Securities Act as follows: (i)&nbsp;in the case of shares of
  Common Stock which may be purchased upon exercise of outstanding
  options, the fee is calculated on the basis of the price at which the
  options may be exercised; and (ii)&nbsp;in the case of shares of Common
  Stock for which options have not yet been granted and the option price
  of which is therefore unknown, the fee is calculated on the basis of
  the average of the high and low sale prices per share of the Common
  Stock on the Nasdaq Stock Market as of a date (June&nbsp;23, 2004) within
  five business days prior to filing this Registration Statement.</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Attached to each share of Common Stock is a right to purchase our
  Series&nbsp;A Preferred Stock, $.01 par value per share, which rights are
  not presently exercisable.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="center" style="font-size: 10pt"><B>EXPLANATORY NOTE</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with the instructional Note to Part&nbsp;I of Form S-8 as
  promulgated by the Securities and Exchange Commission, the information
  specified by Part&nbsp;I of Form S-8 has been omitted from this Registration
  Statement on Form S-8 for offers of Common Stock pursuant to the Plan. This
  Registration Statement on Form S-8 hereby registers 3,000,000 additional shares
  of Common Stock for issuance under the Plan and 135,000 shares of Common Stock
  for issuance under the Sekhri Option Agreement. A Registration Statement on
  Form S-8 (File No.&nbsp;333-63706), registering 1,330,000 shares of Common Stock
  under the Plan, was filed with the Commission on June&nbsp;22, 2001 and a
  Registration on Form S-8 (File No.&nbsp;333-90480), registering an additional
  1,600,000 shares of Common Stock under the Plan, was filed with the Commission
  on June&nbsp;14, 2002.
  
  
  <P align="center" style="font-size: 10pt">2
  </DIV>
  
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  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000"> PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Certain Documents by Reference.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;4. Description of Securities.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Directors and Officers.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005"> Item&nbsp;7. Exemption from Registration Claimed.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;8. Exhibits.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;9. Undertakings.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#008"> SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b51008apexv4w2.txt">Ex-4.2 Certificate of Incorporation</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b51008apexv5w1.txt">Ex-5.1 Opinion of Mintz, Levin</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b51008apexv23w1.txt">Ex-23.1 Consent of Deloitte & Touche LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b51008apexv99w1.txt">Ex-99.1 2001 Stock Incentive Plan, as amended</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  
  <!-- link1 " PART II" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>PART II</B>
  
  
  
  <P align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  
  <!-- link2 "Item&nbsp;3. Incorporation of Certain Documents by Reference." -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;3. Incorporation of Certain Documents by Reference.</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Commission are
  incorporated herein by reference:
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Annual Report on Form 10-K for the fiscal year
  ended December&nbsp;31, 2003 (File No.&nbsp;000-21696);</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Quarterly Report on Form 10-Q for the fiscal
  quarter ended March&nbsp;31, 2004 (File No.&nbsp;000-21696);</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Definitive Proxy Statement filed on April&nbsp;29, 2004
  (File No.&nbsp;000-21696);</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(d)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Reports on Form 8-K filed on February&nbsp;24,
  2004, February&nbsp;27, 2004, March&nbsp;3, 2004, March&nbsp;15, 2004, March&nbsp;24, 2004,
  March&nbsp;29, 2004, March&nbsp;29, 2004, March&nbsp;30, 2004, May&nbsp;6, 2004, May&nbsp;14,
  2004, June&nbsp;9, 2004, June&nbsp;9, 2004, June&nbsp;10, 2004, June&nbsp;15, 2004 and June
  16, 2004 (File Nos. 000-21696);</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(e)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Common Stock contained in the Registrant&#146;s
  Registration Statement on Form&nbsp;10 (File No.&nbsp;000-21696) filed under the
  Securities Exchange Act of 1934 on June&nbsp;25, 1993, including any
  amendment or report filed for the purpose of updating such description;
  and</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(f)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Preferred Share Purchase Rights contained in
  the Registrant&#146;s Registration Statement on Form 8-A (File No.
  000-21696) filed under the Securities and Exchange Act of 1934 on June
  19, 2000, including any amendment or report filed for the purpose of
  updating such description.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents filed by the Registrant after the date
  hereof pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Securities
  Exchange Act of 1934 prior to the filing of a post-effective amendment which
  indicates that all securities offered hereby have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be
  incorporated by reference herein and to be part hereof from the date of filing
  of such reports and documents.
  
  <!-- link2 "Item&nbsp;4. Description of Securities." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;4. Description of Securities.</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the issuance of the shares of Common Stock registered
  under this Registration Statement has been passed upon for the Registrant by
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston, Massachusetts.
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm
  and their families own an aggregate of approximately 5,200 shares of Common
  Stock of the Registrant and 89,285 shares of common stock of the Registrant&#146;s
  majority-owned subsidiary, ARIAD Gene Therapeutics, Inc.
  
  
  <P align="center" style="font-size: 10pt">3
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers." -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(a) of the General Corporation Law of the State of Delaware
  provides that a Delaware corporation may indemnify any person who was or is a
  party or is threatened to be made a party to any threatened, pending or
  completed action, suit or proceeding, whether civil, criminal, administrative
  or investigative (other than an action by or in the right of the corporation)
  by reason of the fact that he is or was a director, officer, employee or agent
  of the corporation or is or was serving at the request of the corporation as a
  director, officer, employee or agent of another corporation or enterprise,
  against expenses, judgments, fines and amounts paid in settlement actually and
  reasonably incurred by him in connection with such action, suit or proceeding
  if he acted in good faith and in a manner he reasonably believed to be in or
  not opposed to the best interests of the corporation, and, with respect to any
  criminal action or proceeding, had no cause to believe his conduct was
  unlawful.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(b) provides that a Delaware corporation may indemnify any
  person who was or is a party or is threatened to be made a party to any
  threatened, pending or completed action or suit by or in the right of the
  corporation to procure a judgment in its favor by reason of the fact that such
  person acted in any of the capacities set forth above, against expenses
  actually and reasonably incurred by him in connection with the defense or
  settlement of such action or suit if he acted under similar standards, except
  that no indemnification may be made in respect of any claim, issue or matter as
  to which such person shall have been adjudged to be liable to the corporation
  unless and only to the extent that the court in which such action or suit was
  brought shall determine that despite the adjudication of liability, such person
  is fairly and reasonably entitled to be indemnified for such expenses which the
  court shall deem proper.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 further provides that to the extent a director or officer of a
  corporation has been successful in the defense of any action, suit or
  proceeding referred to in subsections (a)&nbsp;and (b)&nbsp;or in the defense of any
  claim, issue or matter therein, he shall be indemnified against expenses
  actually and reasonably incurred by him in connection therewith; that
  indemnification provided for by Section&nbsp;145 shall not be deemed exclusive of
  any other rights to which the indemnified party may be entitled; and that the
  corporation may purchase and maintain insurance on behalf of a director or
  officer of the corporation against any liability asserted against him or
  incurred by him in any such capacity or arising out of his status as such
  whether or not the corporation would have the power to indemnify him against
  such liabilities under such Section&nbsp;145.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Certificate of Incorporation, as amended, and By-laws of the
  Registrant provide for indemnification of the Registrant&#146;s directors and
  officers to the fullest extent permitted by law. The By-laws also permit the
  Board of Directors to authorize the Registrant to purchase and maintain
  insurance against any liability asserted against any director, officer,
  employee or agent of the Registrant arising out of his capacity as such.
  Insofar as indemnification for liabilities under the Securities Act may be
  permitted to directors, officers, or controlling persons of the Registrant
  pursuant to the Registrant&#146;s Certificate of Incorporation, as amended, its
  By-laws and the Delaware General Corporation Law, the Registrant has been
  informed that in the opinion of the Commission such indemnification is against
  public policy as expressed in such Act and is therefore unenforceable.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As permitted by the Delaware General Corporation Law, the Registrant&#146;s
  Certificate of Incorporation, as amended, provides that directors of the
  Registrant shall not be personally liable to the Registrant or its stockholders
  for monetary damages for breach of fiduciary duty as a director, except for
  liability (i)&nbsp;for any breach of the director&#146;s duty of loyalty to the
  Registrant or its stockholders, (ii)&nbsp;for acts or omissions not in good faith or
  which involve intentional misconduct or a knowing violation of law, (iii)&nbsp;under
  Section&nbsp;174 of the Delaware General Corporation Law, relating to prohibited
  dividends or distributions or the repurchase or redemption of stock or (iv)&nbsp;for
  any transaction from which the director derives an improper personal benefit.
  As a result of this provision, the Registrant and its stockholders may be
  unable to obtain monetary damages from a director for breach of his or her duty
  of care.
  
  
  <P align="center" style="font-size: 10pt">4
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link2 " Item&nbsp;7. Exemption from Registration Claimed." -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;7. Exemption from Registration Claimed.</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  
  <!-- link2 "Item&nbsp;8. Exhibits." -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;8. Exhibits.</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B>Exhibit</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>&nbsp;</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B>Number</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Description</B><HR size="1" noshade></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Certificate (filed as an exhibit to the
  Registrant&#146;s Registration Statement on Form&nbsp;10, file number 000-21696,
  filed with the Securities and Exchange Commission on June&nbsp;25, 1993 and
  incorporated herein by reference).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Incorporation, as amended.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated By-laws, as amended (filed as Exhibit&nbsp;4.2 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-3, file number 333-38664,
  filed with the Securities and Exchange Commission on June&nbsp;23, 2000 and
  incorporated herein by reference).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, dated as of June&nbsp;8, 2000, between the Registrant
  and State Street Bank and Trust Company, which includes the Form of
  Certificate of Designations in respect of the Series&nbsp;A Preferred Stock,
  as Exhibit&nbsp;A, the Form of Right Certificate as Exhibit&nbsp;B and the Summary
  of Rights to Purchase Series&nbsp;A Preferred Stock as Exhibit&nbsp;C (filed as
  Exhibit&nbsp;1 to the Registrant&#146;s Registration Statement on Form&nbsp;8-A, file
  number 000-21696, filed with the Securities and Exchange Commission on
  June&nbsp;19, 2000 and incorporated herein by reference).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., as to
  the legality of the shares being registered.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (filed
  with Exhibit&nbsp;5.1).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included on signature page).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">ARIAD Pharmaceuticals, Inc. 2001 Stock Plan, as amended.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Non-Qualified Stock Option Agreement, dated October&nbsp;1, 2003, issued
  to Paul J. Sekhri (filed as Exhibit&nbsp;10.8 to the Registrant&#146;s Quarterly
  Report on Form&nbsp;10-Q for the quarter ended September&nbsp;30, 2003, file
  number 000-21696, filed with the Securities and Exchange Commission on
  November&nbsp;4, 2003 and incorporated herein by reference).</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <!-- link2 "Item&nbsp;9. Undertakings." -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;9. Undertakings.</B>
  
  
  
  <P align="left" style="font-size: 10pt">(a)&nbsp;The undersigned Registrant hereby undertakes:
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(i)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To include any prospectus required by Section&nbsp;10(a)(3) of the
  Securities Act of 1933;</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(ii)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the
  aggregate, represents a fundamental change in the information set forth
  in the Registration Statement. Notwithstanding the foregoing, any
  increase or decrease in volume of securities offered (if the total
  dollar value of securities offered would not exceed that which was
  registered)</TD>
  </TR>
  
  </TABLE>
  
  <P align="center" style="font-size: 10pt">5
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>and any deviation from the low or high end of the estimated maximum
  offering range may be reflected in the form of prospectus filed with the
  Commission pursuant to Rule 424(b) (Section&nbsp;230.424(b) of this chapter)
  if, in the aggregate, the changes in volume and price represent no more
  than a 20% change in the maximum aggregate offering price set forth in
  the &#147;Calculation of Registration Fee&#148; table in the effective Registration
  Statement;</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="right">(iii)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or
  any material change to such information in the Registration Statement;</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply
  if the information required to be included in a post-effective amendment by
  those paragraphs is contained in periodic reports filed by the Registrant
  pursuant to Section&nbsp;13 or Section 15(d) of the Securities Exchange Act of 1934
  that are incorporated by reference in this Registration Statement.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That, for the purpose of determining any liability under the
  Securities Act of 1933, each such post-effective amendment shall be deemed to
  be a new registration statement relating to the securities offered therein, and
  the offering of such securities at that time shall be deemed to be the initial
  bona fide offering thereof.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To remove from registration by means of a post-effective amendment any
  of the securities being registered which remain unsold at the termination of
  the offering.
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="right">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act of 1933, each filing of
  the Registrant&#146;s annual report pursuant to Section 13(a) or Section 15(d)
  of the Securities Exchange Act of 1934 that is incorporated by reference
  in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of
  such securities at that time shall be deemed to be the initial bona fide
  offering thereof.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="right">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Insofar as indemnification for liabilities arising under the Securities
  Act of 1933 may be permitted to directors, officers and controlling
  persons of the Registrant pursuant to the foregoing provisions, or
  otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public
  policy as expressed in the Act and is, therefore, unenforceable. In the
  event that a claim for indemnification against such liabilities (other
  than the payment by the Registrant of expenses incurred or paid by a
  director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such
  director, officer or controlling person in connection with the securities
  being registered, the Registrant will, unless in the opinion of its
  counsel the matter has been settled by controlling precedent, submit to a
  court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Act and
  will be governed by the final adjudication of such issue.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="center" style="font-size: 10pt">6
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 " SIGNATURES" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>SIGNATURES</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>The Registrant. </I>Pursuant to the requirements of the Securities Act of
  1933, the Registrant certifies that it has reasonable grounds to believe that
  it meets all of the requirements for filing on Form S-8 and has duly caused
  this Registration Statement to be signed on its behalf by the
  undersigned, thereunto duly authorized, in Cambridge, Massachusetts
  on June 30, 2004.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="55%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="15%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="72%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>ARIAD PHARMACEUTICALS, INC.</B></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By: /s/ Harvey J. Berger, M.D.
  <HR size="1" noshade width="100%" align="left"></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Harvey J. Berger, M.D.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chairman and Chief Executive Officer</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Harvey
  J. Berger and Edward M. Fitzgerald, and each of them, his true and lawful
  attorneys-in-fact and agents, with full power of substitution and
  resubstitution in each of them, for him and in his name, place and stead, and
  in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement on Form S-8 of ARIAD
  Pharmaceuticals, Inc., or any other registration statement for the same
  offering that is to be effective upon filing pursuant to Rule 462(b) under the
  Securities Act of 1933, as amended, and to file the same, with all exhibits
  thereto and other documents in connection therewith, with the Securities and
  Exchange Commission, granting unto said attorneys-in-fact and agents, and each
  of them, full power and authority to do and perform each and every act and
  thing requisite or necessary to be done in or about the premises, as full to
  all intents and purposes as he might or could do in person, hereby ratifying
  and confirming all that said attorneys-in-fact and agents or any of them or
  their or his substitute or substitutes may lawfully do or cause to be done by
  virtue hereof.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed by the following persons in the
  capacities and on the dates indicated.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="50%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><B>Signature</B><HR size="1" noshade width="100%" align="left">
  </TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Title</B><HR size="1" noshade width="100%" align="left">
  </TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Date</B><HR size="1" noshade width="100%" align="left">
  </TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Harvey J. Berger, M.D.
  <HR size="1" noshade width="100%" align="left">
  Harvey J. Berger, M.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chairman of the Board and Chief Executive
  Officer<BR>
  (principal executive officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;23, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Edward M. Fitzgerald
  <HR size="1" noshade width="100%" align="left">
  Edward M. Fitzgerald
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Senior Vice President,
  Chief Financial Officer and Treasurer<BR>
  (principal financial and accounting officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;23, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Jay R. LaMarche
  <HR size="1" noshade width="100%" align="left">
  Jay R. LaMarche
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;23, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade width="100%" align="left"></DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Athanase Lavidas, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Sandford D. Smith
  <HR size="1" noshade>
  Sandford D. Smith
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;23, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Burton E. Sobel, M.D.
  <HR size="1" noshade>
  Burton E. Sobel, M.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;23, 2004</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">7
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="50%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Mary C. Tanner
  <HR size="1" noshade>
  Mary C. Tanner
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;23, 2004</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Elizabeth H.S. Wyatt
  <HR size="1" noshade>
  Elizabeth H.S. Wyatt
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">June&nbsp;23, 2004</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">8
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <P align="center" style="font-size: 10pt"><B>EXHIBIT INDEX</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="6%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="91%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Exhibit</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>&nbsp;</B></TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B>Number</B><HR size="1" noshade></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Description</B><HR size="1" noshade></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Certificate (filed as an exhibit to
  the Registrant&#146;s Registration Statement on Form&nbsp;10, file
  number 000-21696, filed with the Securities and Exchange
  Commission on June&nbsp;25, 1993 and incorporated herein by
  reference).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Incorporation, as amended.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated By-laws, as amended (filed as Exhibit&nbsp;4.2 to the Registrant&#146;s Registration Statement on Form&nbsp;S-3, file number 333-38664,
  filed with the Securities and Exchange Commission on June&nbsp;23, 2000 and incorporated herein by reference).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, dated as of June&nbsp;8, 2000, between the
  Registrant and State Street Bank and Trust Company,
  which includes the Form of Certificate of Designations
  in respect of the Series&nbsp;A Preferred Stock, as Exhibit
  A, the Form of Right Certificate as Exhibit&nbsp;B and the
  Summary of Rights to Purchase Series&nbsp;A Preferred Stock
  as Exhibit&nbsp;C (filed as Exhibit&nbsp;1 to the Registrant&#146;s
  Registration Statement on Form&nbsp;8-A, file number
  000-21696, filed with the Securities and Exchange
  Commission on June&nbsp;19, 2000 and incorporated herein by
  reference).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., as to the legality of the shares being registered.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (filed with Exhibit&nbsp;5.1).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included on signature page).</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">ARIAD Pharmaceuticals, Inc. 2001 Stock Plan, as amended.</TD>
  </TR>
  
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Non-Qualified Stock Option Agreement, dated October&nbsp;1, 2003, issued to Paul J. Sekhri (filed as Exhibit&nbsp;10.8 to the Registrant&#146;s
  Quarterly Report on Form&nbsp;10-Q for the quarter ended September&nbsp;30, 2003, file number 000-21696, filed with the Securities and
  Exchange Commission on November&nbsp;4, 2003 and incorporated herein by reference).</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  
  <P align="center" style="font-size: 10pt">9
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  As filed with the
  Securities and Exchange Commission on June 30, 2004
  REGISTRATION NO. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  under the
  SECURITIES ACT OF 1933
  ARIAD PHARMACEUTICALS, INC.
  (Exact name of Registrant as specified in its charter)
  Delaware
  (
  State or other jurisdiction
  of incorporation or organization
  )
  22-3106987
  (
  I.R.S. Employer
  Identification No.
  )
  26 Landsdowne Street
  Cambridge, Massachusetts 02139
  (617) 494-0400
  (Address of Principal Executive Offices)
  ARIAD PHARMACEUTICALS, INC.
  2001 STOCK PLAN, AS AMENDED
  NON-QUALIFIED STOCK OPTION AGREEMENT,
  DATED OCTOBER 1, 2003, ISSUED TO PAUL J. SEKHRI
  Harvey J. Berger, M.D.
  Chairman and Chief Executive Officer
  ARIAD Pharmaceuticals, Inc.
  26 Landsdowne Street
  Cambridge, Massachusetts 02139-4234
  (617) 494-0400
  (Name, address, including zip code, and telephone number, including area
  code, of agent for service)
  Table of Contents
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  Maximum
  Maximum
  Title of
  Amount to be
  Offering Price
  Aggregate
  Amount of
  Securities to be Registered
  Registered
  (1)
  Per Share
  (2)
  Offering Price
  (2)
  Registration Fee
  Common Stock, $.001 par
  2,807,924
  $
  7.33
  $
  20,582,083
  $
  2,607.75
  value
  (3)
  192,076
  $
  7.44
  $
  1,429,045
  $
  181.06
  135,000
  $
  6.51
  $
  878,850
  $
  111.35
  3,135,000
  $
  2,900.16
  (1)
  The number of shares of common stock, par value $.001 per share
  ("Common Stock"), stated above consists of (i) an aggregate of
  3,000,000 additional shares not previously registered, which may be
  sold upon the exercise of options which have been granted (192,076
  shares) or upon the exercise of options or issuance of stock awards
  which may hereafter be granted (2,807,924 shares) under the ARIAD
  Pharmaceuticals, Inc. 2001 Stock Plan, as amended (the "Plan") and (ii)
  an aggregate of 135,000 shares, which may be sold upon the exercise of
  options granted under that certain Non-Qualified Stock Option
  Agreement, dated October 1, 2003, issued to Paul J. Sekhri (the "Sekhri
  Option Agreement"). The maximum number of shares which may be sold upon
  the exercise of such options or issuance of stock awards granted under
  the Plan and the Sekhri Option Agreement is subject to adjustment in
  accordance with certain anti-dilution and other provisions of the Plan
  and the Sekhri Option Agreement. Accordingly, pursuant to Rule 416
  under the Securities Act of 1933, as amended (the "Securities Act"),
  this Registration Statement covers, in addition to the number of shares
  stated above, an indeterminate number of shares which may be subject to
  grant or otherwise issuable after the operation of any such
  anti-dilution and other provisions.
  (2)
  This calculation is made solely for the purpose of determining the
  registration fee pursuant to the provisions of Rule 457(c) and (h)
  under the Securities Act as follows: (i) in the case of shares of
  Common Stock which may be purchased upon exercise of outstanding
  options, the fee is calculated on the basis of the price at which the
  options may be exercised; and (ii) in the case of shares of Common
  Stock for which options have not yet been granted and the option price
  of which is therefore unknown, the fee is calculated on the basis of
  the average of the high and low sale prices per share of the Common
  Stock on the Nasdaq Stock Market as of a date (June 23, 2004) within
  five business days prior to filing this Registration Statement.
  (3)
  Attached to each share of Common Stock is a right to purchase our
  Series A Preferred Stock, $.01 par value per share, which rights are
  not presently exercisable.
  EXPLANATORY NOTE
  In accordance with the instructional Note to Part I of Form S-8 as
  promulgated by the Securities and Exchange Commission, the information
  specified by Part I of Form S-8 has been omitted from this Registration
  Statement on Form S-8 for offers of Common Stock pursuant to the Plan. This
  Registration Statement on Form S-8 hereby registers 3,000,000 additional shares
  of Common Stock for issuance under the Plan and 135,000 shares of Common Stock
  for issuance under the Sekhri Option Agreement. A Registration Statement on
  Form S-8 (File No. 333-63706), registering 1,330,000 shares of Common Stock
  under the Plan, was filed with the Commission on June 22, 2001 and a
  Registration on Form S-8 (File No. 333-90480), registering an additional
  1,600,000 shares of Common Stock under the Plan, was filed with the Commission
  on June 14, 2002.
  2
  TABLE OF CONTENTS
  PART II
  Item 3. Incorporation of Certain Documents by Reference.
  Item 4. Description of Securities.
  Item 5. Interests of Named Experts and Counsel.
  Item 6. Indemnification of Directors and Officers.
  Item 7. Exemption from Registration Claimed.
  Item 8. Exhibits.
  Item 9. Undertakings.
  SIGNATURES
  Ex-4.2 Certificate of Incorporation
  Ex-5.1 Opinion of Mintz, Levin
  Ex-23.1 Consent of Deloitte & Touche LLP
  Ex-99.1 2001 Stock Incentive Plan, as amended
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference.
  The following documents filed by the Registrant with the Commission are
  incorporated herein by reference:
  (a)
  The Registrant's Annual Report on Form 10-K for the fiscal year
  ended December 31, 2003 (File No. 000-21696);
  (b)
  The Registrant's Quarterly Report on Form 10-Q for the fiscal
  quarter ended March 31, 2004 (File No. 000-21696);
  (c)
  The Registrant's Definitive Proxy Statement filed on April 29, 2004
  (File No. 000-21696);
  (d)
  The Registrant's Current Reports on Form 8-K filed on February 24,
  2004, February 27, 2004, March 3, 2004, March 15, 2004, March 24, 2004,
  March 29, 2004, March 29, 2004, March 30, 2004, May 6, 2004, May 14,
  2004, June 9, 2004, June 9, 2004, June 10, 2004, June 15, 2004 and June
  16, 2004 (File Nos. 000-21696);
  (e)
  The description of the Common Stock contained in the Registrant's
  Registration Statement on Form 10 (File No. 000-21696) filed under the
  Securities Exchange Act of 1934 on June 25, 1993, including any
  amendment or report filed for the purpose of updating such description;
  and
  (f)
  The description of the Preferred Share Purchase Rights contained in
  the Registrant's Registration Statement on Form 8-A (File No.
  000-21696) filed under the Securities and Exchange Act of 1934 on June
  19, 2000, including any amendment or report filed for the purpose of
  updating such description.
  All reports and other documents filed by the Registrant after the date
  hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities
  Exchange Act of 1934 prior to the filing of a post-effective amendment which
  indicates that all securities offered hereby have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be
  incorporated by reference herein and to be part hereof from the date of filing
  of such reports and documents.
  Item 4. Description of Securities.
  Not applicable.
  Item 5. Interests of Named Experts and Counsel.
  The validity of the issuance of the shares of Common Stock registered
  under this Registration Statement has been passed upon for the Registrant by
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston, Massachusetts.
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm
  and their families own an aggregate of approximately 5,200 shares of Common
  Stock of the Registrant and 89,285 shares of common stock of the Registrant's
  majority-owned subsidiary, ARIAD Gene Therapeutics, Inc.
  3
  Table of Contents
  Item 6. Indemnification of Directors and Officers.
  Section 145(a) of the General Corporation Law of the State of Delaware
  provides that a Delaware corporation may indemnify any person who was or is a
  party or is threatened to be made a party to any threatened, pending or
  completed action, suit or proceeding, whether civil, criminal, administrative
  or investigative (other than an action by or in the right of the corporation)
  by reason of the fact that he is or was a director, officer, employee or agent
  of the corporation or is or was serving at the request of the corporation as a
  director, officer, employee or agent of another corporation or enterprise,
  against expenses, judgments, fines and amounts paid in settlement actually and
  reasonably incurred by him in connection with such action, suit or proceeding
  if he acted in good faith and in a manner he reasonably believed to be in or
  not opposed to the best interests of the corporation, and, with respect to any
  criminal action or proceeding, had no cause to believe his conduct was
  unlawful.
  Section 145(b) provides that a Delaware corporation may indemnify any
  person who was or is a party or is threatened to be made a party to any
  threatened, pending or completed action or suit by or in the right of the
  corporation to procure a judgment in its favor by reason of the fact that such
  person acted in any of the capacities set forth above, against expenses
  actually and reasonably incurred by him in connection with the defense or
  settlement of such action or suit if he acted under similar standards, except
  that no indemnification may be made in respect of any claim, issue or matter as
  to which such person shall have been adjudged to be liable to the corporation
  unless and only to the extent that the court in which such action or suit was
  brought shall determine that despite the adjudication of liability, such person
  is fairly and reasonably entitled to be indemnified for such expenses which the
  court shall deem proper.
  Section 145 further provides that to the extent a director or officer of a
  corporation has been successful in the defense of any action, suit or
  proceeding referred to in subsections (a) and (b) or in the defense of any
  claim, issue or matter therein, he shall be indemnified against expenses
  actually and reasonably incurred by him in connection therewith; that
  indemnification provided for by Section 145 shall not be deemed exclusive of
  any other rights to which the indemnified party may be entitled; and that the
  corporation may purchase and maintain insurance on behalf of a director or
  officer of the corporation against any liability asserted against him or
  incurred by him in any such capacity or arising out of his status as such
  whether or not the corporation would have the power to indemnify him against
  such liabilities under such Section 145.
  The Certificate of Incorporation, as amended, and By-laws of the
  Registrant provide for indemnification of the Registrant's directors and
  officers to the fullest extent permitted by law. The By-laws also permit the
  Board of Directors to authorize the Registrant to purchase and maintain
  insurance against any liability asserted against any director, officer,
  employee or agent of the Registrant arising out of his capacity as such.
  Insofar as indemnification for liabilities under the Securities Act may be
  permitted to directors, officers, or controlling persons of the Registrant
  pursuant to the Registrant's Certificate of Incorporation, as amended, its
  By-laws and the Delaware General Corporation Law, the Registrant has been
  informed that in the opinion of the Commission such indemnification is against
  public policy as expressed in such Act and is therefore unenforceable.
  As permitted by the Delaware General Corporation Law, the Registrant's
  Certificate of Incorporation, as amended, provides that directors of the
  Registrant shall not be personally liable to the Registrant or its stockholders
  for monetary damages for breach of fiduciary duty as a director, except for
  liability (i) for any breach of the director's duty of loyalty to the
  Registrant or its stockholders, (ii) for acts or omissions not in good faith or
  which involve intentional misconduct or a knowing violation of law, (iii) under
  Section 174 of the Delaware General Corporation Law, relating to prohibited
  dividends or distributions or the repurchase or redemption of stock or (iv) for
  any transaction from which the director derives an improper personal benefit.
  As a result of this provision, the Registrant and its stockholders may be
  unable to obtain monetary damages from a director for breach of his or her duty
  of care.
  4
  Table of Contents
  Item 7. Exemption from Registration Claimed.
  Not applicable.
  Item 8. Exhibits.
  Exhibit
  Number
  Description
  4.1
  Form of Common Stock Certificate (filed as an exhibit to the
  Registrant's Registration Statement on Form 10, file number 000-21696,
  filed with the Securities and Exchange Commission on June 25, 1993 and
  incorporated herein by reference).
  4.2
  Certificate of Incorporation, as amended.
  4.3
  Restated By-laws, as amended (filed as Exhibit 4.2 to the
  Registrant's Registration Statement on Form S-3, file number 333-38664,
  filed with the Securities and Exchange Commission on June 23, 2000 and
  incorporated herein by reference).
  4.4
  Rights Agreement, dated as of June 8, 2000, between the Registrant
  and State Street Bank and Trust Company, which includes the Form of
  Certificate of Designations in respect of the Series A Preferred Stock,
  as Exhibit A, the Form of Right Certificate as Exhibit B and the Summary
  of Rights to Purchase Series A Preferred Stock as Exhibit C (filed as
  Exhibit 1 to the Registrant's Registration Statement on Form 8-A, file
  number 000-21696, filed with the Securities and Exchange Commission on
  June 19, 2000 and incorporated herein by reference).
  5.1
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., as to
  the legality of the shares being registered.
  23.1
  Consent of Deloitte & Touche LLP.
  23.2
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (filed
  with Exhibit 5.1).
  24.1
  Power of Attorney (included on signature page).
  99.1
  ARIAD Pharmaceuticals, Inc. 2001 Stock Plan, as amended.
  99.2
  Non-Qualified Stock Option Agreement, dated October 1, 2003, issued
  to Paul J. Sekhri (filed as Exhibit 10.8 to the Registrant's Quarterly
  Report on Form 10-Q for the quarter ended September 30, 2003, file
  number 000-21696, filed with the Securities and Exchange Commission on
  November 4, 2003 and incorporated herein by reference).
  Item 9. Undertakings.
  (a) The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:
  (i)
  To include any prospectus required by Section 10(a)(3) of the
  Securities Act of 1933;
  (ii)
  To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent
  post-effective amendment thereof) which, individually or in the
  aggregate, represents a fundamental change in the information set forth
  in the Registration Statement. Notwithstanding the foregoing, any
  increase or decrease in volume of securities offered (if the total
  dollar value of securities offered would not exceed that which was
  registered)
  5
  Table of Contents
  and any deviation from the low or high end of the estimated maximum
  offering range may be reflected in the form of prospectus filed with the
  Commission pursuant to Rule 424(b) (Section 230.424(b) of this chapter)
  if, in the aggregate, the changes in volume and price represent no more
  than a 20% change in the maximum aggregate offering price set forth in
  the "Calculation of Registration Fee" table in the effective Registration
  Statement;
  (iii)
  To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or
  any material change to such information in the Registration Statement;
  Provided, however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply
  if the information required to be included in a post-effective amendment by
  those paragraphs is contained in periodic reports filed by the Registrant
  pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934
  that are incorporated by reference in this Registration Statement.
  (2) That, for the purpose of determining any liability under the
  Securities Act of 1933, each such post-effective amendment shall be deemed to
  be a new registration statement relating to the securities offered therein, and
  the offering of such securities at that time shall be deemed to be the initial
  bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment any
  of the securities being registered which remain unsold at the termination of
  the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act of 1933, each filing of
  the Registrant's annual report pursuant to Section 13(a) or Section 15(d)
  of the Securities Exchange Act of 1934 that is incorporated by reference
  in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of
  such securities at that time shall be deemed to be the initial bona fide
  offering thereof.
  (c)
  Insofar as indemnification for liabilities arising under the Securities
  Act of 1933 may be permitted to directors, officers and controlling
  persons of the Registrant pursuant to the foregoing provisions, or
  otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public
  policy as expressed in the Act and is, therefore, unenforceable. In the
  event that a claim for indemnification against such liabilities (other
  than the payment by the Registrant of expenses incurred or paid by a
  director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such
  director, officer or controlling person in connection with the securities
  being registered, the Registrant will, unless in the opinion of its
  counsel the matter has been settled by controlling precedent, submit to a
  court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Act and
  will be governed by the final adjudication of such issue.
  6
  Table of Contents
  SIGNATURES
  The Registrant.
  Pursuant to the requirements of the Securities Act of
  1933, the Registrant certifies that it has reasonable grounds to believe that
  it meets all of the requirements for filing on Form S-8 and has duly caused
  this Registration Statement to be signed on its behalf by the
  undersigned, thereunto duly authorized, in Cambridge, Massachusetts
  on June 30, 2004.
  ARIAD PHARMACEUTICALS, INC.
  By: /s/ Harvey J. Berger, M.D.
  Harvey J. Berger, M.D.
  Chairman and Chief Executive Officer
  Each person whose signature appears below constitutes and appoints Harvey
  J. Berger and Edward M. Fitzgerald, and each of them, his true and lawful
  attorneys-in-fact and agents, with full power of substitution and
  resubstitution in each of them, for him and in his name, place and stead, and
  in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement on Form S-8 of ARIAD
  Pharmaceuticals, Inc., or any other registration statement for the same
  offering that is to be effective upon filing pursuant to Rule 462(b) under the
  Securities Act of 1933, as amended, and to file the same, with all exhibits
  thereto and other documents in connection therewith, with the Securities and
  Exchange Commission, granting unto said attorneys-in-fact and agents, and each
  of them, full power and authority to do and perform each and every act and
  thing requisite or necessary to be done in or about the premises, as full to
  all intents and purposes as he might or could do in person, hereby ratifying
  and confirming all that said attorneys-in-fact and agents or any of them or
  their or his substitute or substitutes may lawfully do or cause to be done by
  virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed by the following persons in the
  capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Harvey J. Berger, M.D.
  Harvey J. Berger, M.D.
  Chairman of the Board and Chief Executive
  Officer
  (principal executive officer)
  June 23, 2004
  /s/ Edward M. Fitzgerald
  Edward M. Fitzgerald
  Senior Vice President,
  Chief Financial Officer and Treasurer
  (principal financial and accounting officer)
  June 23, 2004
  /s/ Jay R. LaMarche
  Jay R. LaMarche
  Director
  June 23, 2004
  Director
  Athanase Lavidas, Ph.D.
  /s/ Sandford D. Smith
  Sandford D. Smith
  Director
  June 23, 2004
  /s/ Burton E. Sobel, M.D.
  Burton E. Sobel, M.D.
  Director
  June 23, 2004
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  Table of Contents
  /s/ Mary C. Tanner
  Mary C. Tanner
  Director
  June 23, 2004
  /s/ Elizabeth H.S. Wyatt
  Elizabeth H.S. Wyatt
  Director
  June 23, 2004
  8
  Table of Contents
  EXHIBIT INDEX
  Exhibit
  Number
  Description
  4.1
  Form of Common Stock Certificate (filed as an exhibit to
  the Registrant's Registration Statement on Form 10, file
  number 000-21696, filed with the Securities and Exchange
  Commission on June 25, 1993 and incorporated herein by
  reference).
  4.2
  Certificate of Incorporation, as amended.
  4.3
  Restated By-laws, as amended (filed as Exhibit 4.2 to the Registrant's Registration Statement on Form S-3, file number 333-38664,
  filed with the Securities and Exchange Commission on June 23, 2000 and incorporated herein by reference).
  4.4
  Rights Agreement, dated as of June 8, 2000, between the
  Registrant and State Street Bank and Trust Company,
  which includes the Form of Certificate of Designations
  in respect of the Series A Preferred Stock, as Exhibit
  A, the Form of Right Certificate as Exhibit B and the
  Summary of Rights to Purchase Series A Preferred Stock
  as Exhibit C (filed as Exhibit 1 to the Registrant's
  Registration Statement on Form 8-A, file number
  000-21696, filed with the Securities and Exchange
  Commission on June 19, 2000 and incorporated herein by
  reference).
  5.1
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., as to the legality of the shares being registered.
  23.1
  Consent of Deloitte & Touche LLP.
  23.2
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (filed with Exhibit 5.1).
  24.1
  Power of Attorney (included on signature page).
  99.1
  ARIAD Pharmaceuticals, Inc. 2001 Stock Plan, as amended.
  99.2
  Non-Qualified Stock Option Agreement, dated October 1, 2003, issued to Paul J. Sekhri (filed as Exhibit 10.8 to the Registrant's
  Quarterly Report on Form 10-Q for the quarter ended September 30, 2003, file number 000-21696, filed with the Securities and
  Exchange Commission on November 4, 2003 and incorporated herein by reference).
  9