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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549<BR>
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>ARQULE, INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact Name of registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top">Delaware
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">58-1959440</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or other jurisdiction of
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Identification No.)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">19 Presidential Way,<BR>
  <U>Woburn, Massachusetts 01801 </U><BR>
  (Address, including zip code, of principal executive offices)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><U>ArQule, Inc. 2005 Director Stock Compensation Plan</U><BR>
  (Full title of the plan)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">Dr.&nbsp;Stephen A. Hill<BR>
  President and Chief Executive Officer<BR>
  ArQule, Inc.<BR>
  19 Presidential Way,<BR>
  Woburn, Massachusetts 01801<BR>
  (781)&nbsp;994-0300</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">(Name, address, including zip code, and telephone number including area code, of agent for service)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">Copy to:<BR>
  Richard E. Baltz, Esq.<BR>
  Arnold &#038; Porter<BR>
  555 12<SUP style="font-size: 85%; vertical-align: text-top">th</SUP> Street, N.W.<BR>
  Washington, D.C. 20004<BR>
  (202)&nbsp;942-5124<BR>
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">Calculation of Registration Fee</DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
  
  <TD nowrap align="left" colspan="23" style="border-bottom: 3px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of securities to be</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount to be</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed maximum</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center" style="border-bottom: 0px solid #000000"> registered</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3" style="border-bottom: 0px solid #000000">registered (1)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">maximum offering</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">aggregate offering</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3" style="border-bottom: 0px solid #000000">registration fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">price per unit (2)(3)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">price (3)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock,
  $.01 par value</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">250,000</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">7.03</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">1,757,500</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 1px solid #000000">$</TD>
      <TD align="right" style="border-top: 1px solid #000000">188.05</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px solid #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 0px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Pursuant to Rule&nbsp;416, promulgated under the Securities Act of 1933, as amended, an
  additional undeterminable number of shares of Common Stock is being registered to cover any
  adjustment in the number of shares of Common Stock issuable pursuant to the anti-dilution
  provisions of the 2005 Director Stock Compensation Plan.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Calculated on the basis of the average of the high and low sale prices of the Registrant&#146;s
  Common Stock as reported on December&nbsp;1, 2005 on the Nasdaq National Market which date is
  within 5 business days prior to the date of the filing of this Registration Statement.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of determining the registration fee in accordance with Rule
  457(h).</TD>
  </TR>
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000"> PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;8. Exhibits</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#004">INDEX TO EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b58042aiexv4.htm">EX-4 2005 DIRECTOR STOCK COMPENSATION PLAN</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b58042aiexv5.htm">EX-5 OPINION OF ROBERT J. CONNAUGHTON, JR.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b58042aiexv23w2.htm">EX-23.2 CONSENT OF PRICEWATERHOUSECOOPERS LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b58042aiexv24.htm">EX-24 POWER OF ATTORNEY</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link1 " PART II " -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></DIV>
  
  
  <!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;3. </B><U><B>Incorporation of Documents by Reference</B></U><B>.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Company (File No.&nbsp;000-21429) with the Commission under
  the Securities Exchange Act of 1934, as amended (&#147;Exchange Act&#148;), are incorporated herein by
  reference:
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Company&#146;s Annual Report on Form 10-K for the year ended December&nbsp;31, 2004, filed with the
  Commission on March&nbsp;16, 2005;</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Company&#146;s Quarterly Report on Form 10-Q for the quarter ended March&nbsp;31, 2005, filed with
  the Commission on April&nbsp;29, 2005;</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Company&#146;s Quarterly Report on Form 10-Q for the quarter ended June&nbsp;30, 2005, filed with
  the Commission on August&nbsp;5, 2005;</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(d)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Company&#146;s Quarterly Report on Form 10-Q for the quarter ended September&nbsp;30, 2005, filed
  with the Commission on November&nbsp;4, 2005;</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(e)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Company&#146;s Current Reports on Form 8-K filed with the Commission on January&nbsp;24, 2005,
  January&nbsp;25, 2005, January&nbsp;31, 2005, February&nbsp;18, 2005, April&nbsp;7, 2005, April&nbsp;11, 2005, May&nbsp;6,
  2005, June&nbsp;15, 2005; September&nbsp;16, 2005, September&nbsp;30, 2005, October&nbsp;17, 2005, and November
  17, 2005; and</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(f)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Company&#146;s Common Stock contained in a registration statement on Form
  8-A filed with the Commission on September&nbsp;25, 1996, and any amendments or reports filed for
  the purpose of updating such description.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Registrant after the date of this Registration Statement pursuant
  to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
  amendment which indicates that all Common Stock offered hereby has been sold or which deregisters
  such Common Stock then remaining unsold, shall be deemed to be incorporated in this Registration
  Statement by reference and shall be a part hereof from the date of filing of such documents. Any
  statement contained in a document incorporated or deemed to be incorporated by reference in this
  Registration Statement shall be deemed to be modified or superseded for purposes of this
  Registration Statement to the extent that a statement contained herein or in any other subsequently
  filed document which also is or is deemed to be incorporated by reference in this Registration
  Statement modifies or supersedes such statement. Any such statement so modified or superseded
  shall not be deemed, except as so modified or so superseded, to constitute a part of this
  Registration Statement.
  </DIV>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8.
  </B>&nbsp;&nbsp;&nbsp;<U><B>Exhibits</B></U>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="7%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="90%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">ArQule, Inc. 2005 Director Stock Compensation Plan.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Robert J. Connaughton, Jr., filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Robert J. Connaughton, Jr., included in the
  opinion filed as Exhibit&nbsp;5 hereto.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, independent registered
  public accounting firm, filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;24
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Powers of Attorney of certain officers and directors of ArQule, Inc., filed herewith.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U><B>SIGNATURES</B></U>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Company certifies
  that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned
  thereunto duly authorized in the City of Woburn,
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Commonwealth
  of Massachusetts, on December&nbsp;5, 2005.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">ARQULE, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Stephen A. Hill
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Stephen A. Hill&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">President and Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, this registration
  statement has been signed by the following persons in the capacities and on the dates indicated:
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Signature</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Title</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Date</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="left" valign="top">/s/ Stephen A. Hill
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Stephen A. Hill</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  President, Chief Executive
  Officer and Director
  (Principal Executive
  Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Louise A. Mawhinney
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Louise A. Mawhinney</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Vice President, Chief
  Financial Officer,
  Treasurer and Secretary
  (Principal Accounting and
  Financial Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Patrick J. Zenner
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Patrick J. Zenner</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Michael J. Astrue
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Michael J. Astrue</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Laura Avakian
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Laura Avakian</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Timothy C. Barabe
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Timothy C. Barabe</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Werner Cautreels
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Werner Cautreels</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Tuan Ha-Ngoc
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Tuan Ha-Ngoc</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ Ronald M. Lindsay
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  Ronald M. Lindsay</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" valign="top">/s/ William G. Messenger
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  William G. Messenger</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">December 5, 2005</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "INDEX TO EXHIBITS" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U><B>INDEX TO EXHIBITS</B></U>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="7%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="90%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">ArQule, Inc. 2005 Director Stock Compensation Plan, filed
  herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Robert J. Connaughton, Jr., filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Robert J. Connaughton, Jr., included in the
  opinion filed as Exhibit&nbsp;5 hereto.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, independent registered
  public accounting firm, filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;24
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Powers of Attorney of certain officers and directors of
  ArQule, Inc., filed herewith.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
  ARQULE, INC.
  (Exact Name of registrant as specified in its charter)
  Delaware
  58-1959440
  (State or other jurisdiction of
  (I.R.S. Employer
  incorporation or organization)
  Identification No.)
  19 Presidential Way,
  Woburn, Massachusetts 01801
  (Address, including zip code, of principal executive offices)
  ArQule, Inc. 2005 Director Stock Compensation Plan
  (Full title of the plan)
  Dr. Stephen A. Hill
  President and Chief Executive Officer
  ArQule, Inc.
  19 Presidential Way,
  Woburn, Massachusetts 01801
  (781) 994-0300
  (Name, address, including zip code, and telephone number including area code, of agent for service)
  Copy to:
  Richard E. Baltz, Esq.
  Arnold & Porter
  555 12
  th
  Street, N.W.
  Washington, D.C. 20004
  (202) 942-5124
  Calculation of Registration Fee
  Title of securities to be
  Amount to be
  Proposed
  Proposed maximum
  Amount of
  registered
  registered (1)
  maximum offering
  aggregate offering
  registration fee
  price per unit (2)(3)
  price (3)
  Common Stock,
  $.01 par value
  250,000
  $
  7.03
  $
  1,757,500
  $
  188.05
  (1)
  Pursuant to Rule 416, promulgated under the Securities Act of 1933, as amended, an
  additional undeterminable number of shares of Common Stock is being registered to cover any
  adjustment in the number of shares of Common Stock issuable pursuant to the anti-dilution
  provisions of the 2005 Director Stock Compensation Plan.
  (2)
  Calculated on the basis of the average of the high and low sale prices of the Registrant's
  Common Stock as reported on December 1, 2005 on the Nasdaq National Market which date is
  within 5 business days prior to the date of the filing of this Registration Statement.
  (3)
  Estimated solely for the purpose of determining the registration fee in accordance with Rule
  457(h).
  TABLE OF CONTENTS
  PART II
  Item 3. Incorporation of Documents by Reference
  Item 8. Exhibits
  SIGNATURES
  INDEX TO EXHIBITS
  EX-4 2005 DIRECTOR STOCK COMPENSATION PLAN
  EX-5 OPINION OF ROBERT J. CONNAUGHTON, JR.
  EX-23.2 CONSENT OF PRICEWATERHOUSECOOPERS LLP
  EX-24 POWER OF ATTORNEY
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference
  .
  The following documents filed by the Company (File No. 000-21429) with the Commission under
  the Securities Exchange Act of 1934, as amended ("Exchange Act"), are incorporated herein by
  reference:
  (a)
  The Company's Annual Report on Form 10-K for the year ended December 31, 2004, filed with the
  Commission on March 16, 2005;
  (b)
  The Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2005, filed with
  the Commission on April 29, 2005;
  (c)
  The Company's Quarterly Report on Form 10-Q for the quarter ended June 30, 2005, filed with
  the Commission on August 5, 2005;
  (d)
  The Company's Quarterly Report on Form 10-Q for the quarter ended September 30, 2005, filed
  with the Commission on November 4, 2005;
  (e)
  The Company's Current Reports on Form 8-K filed with the Commission on January 24, 2005,
  January 25, 2005, January 31, 2005, February 18, 2005, April 7, 2005, April 11, 2005, May 6,
  2005, June 15, 2005; September 16, 2005, September 30, 2005, October 17, 2005, and November
  17, 2005; and
  (f)
  The description of the Company's Common Stock contained in a registration statement on Form
  8-A filed with the Commission on September 25, 1996, and any amendments or reports filed for
  the purpose of updating such description.
  All documents filed by the Registrant after the date of this Registration Statement pursuant
  to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
  amendment which indicates that all Common Stock offered hereby has been sold or which deregisters
  such Common Stock then remaining unsold, shall be deemed to be incorporated in this Registration
  Statement by reference and shall be a part hereof from the date of filing of such documents. Any
  statement contained in a document incorporated or deemed to be incorporated by reference in this
  Registration Statement shall be deemed to be modified or superseded for purposes of this
  Registration Statement to the extent that a statement contained herein or in any other subsequently
  filed document which also is or is deemed to be incorporated by reference in this Registration
  Statement modifies or supersedes such statement. Any such statement so modified or superseded
  shall not be deemed, except as so modified or so superseded, to constitute a part of this
  Registration Statement.
  Table of Contents
  Item 8.
  Exhibits
  Exhibit 4
  ArQule, Inc. 2005 Director Stock Compensation Plan.
  Exhibit 5
  Opinion of Robert J. Connaughton, Jr., filed herewith.
  Exhibit 23.1
  Consent of Robert J. Connaughton, Jr., included in the
  opinion filed as Exhibit 5 hereto.
  Exhibit 23.2
  Consent of PricewaterhouseCoopers LLP, independent registered
  public accounting firm, filed herewith.
  Exhibit 24
  Powers of Attorney of certain officers and directors of ArQule, Inc., filed herewith.
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the Company certifies
  that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned
  thereunto duly authorized in the City of Woburn,
  Commonwealth
  of Massachusetts, on December 5, 2005.
  ARQULE, INC.
  By:
  /s/ Stephen A. Hill
  Stephen A. Hill
  President and Chief Executive Officer
  Pursuant to the requirements of the Securities Act of 1933, as amended, this registration
  statement has been signed by the following persons in the capacities and on the dates indicated:
  Signature
  Title
  Date
  /s/ Stephen A. Hill
  Stephen A. Hill
  President, Chief Executive
  Officer and Director
  (Principal Executive
  Officer)
  December 5, 2005
  /s/ Louise A. Mawhinney
  Louise A. Mawhinney
  Vice President, Chief
  Financial Officer,
  Treasurer and Secretary
  (Principal Accounting and
  Financial Officer)
  December 5, 2005
  /s/ Patrick J. Zenner
  Patrick J. Zenner
  Chairman of the Board
  December 5, 2005
  /s/ Michael J. Astrue
  Michael J. Astrue
  Director
  December 5, 2005
  /s/ Laura Avakian
  Laura Avakian
  Director
  December 5, 2005
  /s/ Timothy C. Barabe
  Timothy C. Barabe
  Director
  December 5, 2005
  /s/ Werner Cautreels
  Werner Cautreels
  Director
  December 5, 2005
  /s/ Tuan Ha-Ngoc
  Tuan Ha-Ngoc
  Director
  December 5, 2005
  /s/ Ronald M. Lindsay
  Ronald M. Lindsay
  Director
  December 5, 2005
  /s/ William G. Messenger
  William G. Messenger
  Director
  December 5, 2005
  Table of Contents
  INDEX TO EXHIBITS
  Exhibit 4
  ArQule, Inc. 2005 Director Stock Compensation Plan, filed
  herewith.
  Exhibit 5
  Opinion of Robert J. Connaughton, Jr., filed herewith.
  Exhibit 23.1
  Consent of Robert J. Connaughton, Jr., included in the
  opinion filed as Exhibit 5 hereto.
  Exhibit 23.2
  Consent of PricewaterhouseCoopers LLP, independent registered
  public accounting firm, filed herewith.
  Exhibit 24
  Powers of Attorney of certain officers and directors of
  ArQule, Inc., filed herewith.