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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  <P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
  </DIV>
  
  <p align="center" style="font-size: 12pt"><B><HR size="1" noshade width="20%" align="center" color="#000000"></B>
  
  
  <P align="center" style="font-size: 18pt"><B>FORM S-8</B>
  
  
  <P align="center" style="font-size: 12pt"><b>REGISTRATION STATEMENT
  UNDER THE SECURITIES ACT OF 1933</b>
  
  
  <P align="center" style="font-size: 24pt"><B>ARQULE, INC.</B>
  
  
  <DIV align="center" style="font-size: 10pt">(Exact Name of registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top">Delaware
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">58-1959440</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or other jurisdiction of
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Identification No.)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">19 Presidential Way,<BR>
  <U>Woburn, Massachusetts 01801</U><BR>
  (Address, including zip code, of principal executive offices)
  
  
  
  <P align="center" style="font-size: 10pt"><U>ArQule, Inc. Amended and Restated 1996 Director Stock Option Plan</U><BR>
  (Full title of the plan)
  
  
  
  <P align="center" style="font-size: 10pt">Dr.&nbsp;Stephen A. Hill<BR>
  President and Chief Executive Officer<BR>
  ArQule, Inc.<BR>
  19 Presidential Way,<BR>
  Woburn, Massachusetts 01801<BR>
  (781)&nbsp;994-0300
  
  
  
  <P align="center" style="font-size: 10pt">(Name, address, including zip code, and telephone number including area code, of agent for service)
  
  
  
  <P align="center" style="font-size: 10pt">Copy to:<BR>
  Richard E. Baltz, Esq.<BR>
  Arnold &#038; Porter<BR>
  555 12<SUP style="font-size: 85%; vertical-align: text-top">th</SUP> Street, N.W.<BR>
  Washington, D.C. 20004<BR>
  (202)&nbsp;942-5124
  
  
  
  <P align="center" style="font-size: 10pt"><HR size="1" noshade width="20%" align="center" color="#000000">
  
  
  
  <P align="center" style="font-size: 10pt">Calculation of Registration Fee
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="62%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
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      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD><!-- VRule -->
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%" style="border-left: 1px solid #000000">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%" style="border-right: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%" style="border-left: 1px solid #000000">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">maximum offering</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed maximum</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%" style="border-right: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%" style="border-left: 1px solid #000000">&nbsp;</TD>
  
      <TD nowrap align="center">Title of securities to be</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount to be</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">price per unit</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">aggregate offering</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%" style="border-right: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%" style="border-left: 1px solid #000000">&nbsp;</TD>
  
      <TD nowrap align="center"> registered</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">registered (1)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">(2)(3)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">price (3)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">registration fee</TD>
      <TD width="1%" style="border-right: 1px solid #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-left: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="top" style="border-top: 1px solid #000000"><DIV style="margin-center:0px; text-indent:-0px">Common Stock,
  $.01 par value
  </DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">60,000</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">$5.02</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid
  #000000">$301,200</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="right" valign="top" style="border-top: 1px solid #000000">$35.45</TD>
      <TD nowrap valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <P>
  <div><HR noshade size="1" width="15%" align="left" color="#000000">
  </div>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(1)&nbsp;&nbsp;</TD>
      <TD>Pursuant to Rule&nbsp;416, promulgated under the Securities Act of 1933, as amended, an
  additional undeterminable number of shares of Common Stock is being registered to cover any
  adjustment in the number of shares of Common Stock issuable pursuant to the anti-dilution
  provisions of the Amended and Restated 1996 Director Stock Option Plan.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(2)&nbsp;&nbsp;</TD>
      <TD>Calculated on the basis of the average of the high and low sale prices of the Registrant&#146;s
  Common Stock as reported on April 6, 2005 on the Nasdaq National Market which date is within 5
  business days prior to the date of the filing of this Registration Statement.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(3)&nbsp;&nbsp;</TD>
      <TD>Estimated solely for the purpose of determining the registration fee in accordance with Rule
  457(h).</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">The prospectus which will be part of this registration statement is a combined prospectus
  under SEC Rule&nbsp;429 intended to be used for the offering of (a)&nbsp;the shares of the Company&#146;s Common
  Stock registered hereunder, and (b)&nbsp;the shares of the Company&#146;s Common Stock remaining to be issued
  which have been previously registered by Registration Statements on Form&nbsp;S-8 File Nos. 333-25369,
  333-43046, and 333-105297.
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000"> EXPLANATORY NOTE AND INCORPORATION BY REFERENCE &#043;</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#001"> PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;3. Incorporation of Documents by Reference.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;8. Exhibits</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#004">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#005">INDEX TO EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b54242aiexv4.htm">EX-4 ArQule, Inc. Amended and Restated 1996 Director Stock Option Plan, as amended</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b54242aiexv5.htm">EX-5 Opinion of Robert J. Connaughton, Jr., filed herewith</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b54242aiexv23w2.htm">EX-23.2 Consent of PricewaterhouseCoopers LLP, filed herewith</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b54242aiexv24.htm">EX-24 Powers of Attorney of certain officers and directors of ArQule, Inc., filed herewith</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link1 " EXPLANATORY NOTE AND INCORPORATION BY REFERENCE &#043;" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="center" style="font-size: 10pt">EXPLANATORY NOTE AND INCORPORATION BY REFERENCE
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement registers additional securities of the same class as other
  securities for which a registration statement filed on Form S-8 relating to the ArQule, Inc. (the
  &#147;Company&#148;) Amended and Restated 1996 Director Stock Option Plan (the &#147;Plan&#148;) is already effective.
  In accordance with General Instruction E to Form S-8, the contents of (i)&nbsp;the Company&#146;s
  Registration Statement on Form S-8 (File No.&nbsp;333-25369) filed with the Securities Exchange
  Commission (the &#147;Commission&#148;) on April&nbsp;17, 1997, relating to the registration of 125,000 shares of
  the Company&#146;s common stock, $.01 par value per share (the &#147;Common Stock&#148;) authorized for issuance
  under the Plan, (ii)&nbsp;the Company&#146;s Registration Statement on Form S-8 (File No.&nbsp;333-43046) filed
  with the Commission on August&nbsp;4, 2000, relating to the registration of 65,500 shares of Common
  Stock authorized for issuance under the Plan, and (iii)&nbsp;the Company&#146;s Registration Statement on
  Form S-8 (File No.&nbsp;333-105297) filed with the Commission on May&nbsp;15, 2003, relating to the
  registration of 100,000 shares of Common Stock authorized for issuance under the Plan are
  incorporated by reference in their entirety in this Registration Statement.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement provides for the registration of an additional 60,000 shares of
  Common Stock authorized for issuance under the Plan.
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 " PART II" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>PART II</B>
  
  
  <DIV align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></DIV>
  
  
  <!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;3. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporation of Documents by Reference.</B>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Company (File No.&nbsp;000-20713) with the Commission under
  the Securities Exchange Act of 1934, as amended (&#147;Exchange Act&#148;), are incorporated herein by
  reference:
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(a)&nbsp;&nbsp;</TD>
      <TD>The Company&#146;s Annual Report on Form 10-K for the year ended December&nbsp;31, 2004, filed with the
  Commission on March&nbsp;16, 2005.</TD>
  </TR>
  
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)&nbsp;&nbsp;</TD>
      <TD>The description of the Company&#146;s Common Stock contained in a registration statement on Form
  8-A filed with the Commission on September&nbsp;25, 1996, and any amendments or reports filed for
  the purpose of updating such description.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Registrant after the date of this Registration Statement pursuant
  to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
  amendment which indicates that all Common Stock offered hereby has been sold or which deregisters
  such Common Stock then remaining unsold, shall be deemed to be incorporated in this Registration
  Statement by reference and shall be a part hereof from the date of filing of such documents. Any
  statement contained in a document incorporated or deemed to be incorporated by reference in this
  Registration Statement shall be deemed to be modified or superseded for purposes of this
  Registration Statement to the extent that a statement contained herein or in any other subsequently
  filed document which also is or is deemed to be incorporated by reference in this Registration
  Statement modifies or supersedes such statement. Any such statement so modified or superseded
  shall not be deemed, except as so modified or so superseded, to constitute a part of this
  Registration Statement.
  
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B>Item&nbsp;8. Exhibits</B>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="13%">&nbsp;</TD>
      <TD width="0%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">ArQule, Inc. Amended and Restated 1996 Director Stock Option Plan, as amended.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Robert J. Connaughton, Jr., filed herewith.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Robert J. Connaughton, Jr., included in the
  opinion filed as Exhibit&nbsp;5 hereto.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, filed herewith.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;24
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Powers of Attorney of certain officers and directors of ArQule, Inc., filed herewith.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B><U>SIGNATURES</U></B>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Company certifies
  that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned
  thereunto duly authorized in the City of Woburn, State of Massachusetts, on March&nbsp;16, 2005.
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">ARQULE, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Stephen A. Hill
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Stephen A. Hill&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">President and Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, this registration
  statement has been signed by the following persons in the capacities and on the dates indicated:
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="35%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="45%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="14%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><U>Signature</U>
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><U>Title</U>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><U>Date</U></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Stephen A. Hill
  <HR size="1" noshade color="#000000">
  Stephen A. Hill
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">President, Chief Executive<BR>
  Officer and Director
  (Principal<BR>
   Executive Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March&nbsp;16, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Louise A. Mawhinney
  <HR size="1" noshade color="#000000">
  Louise A. Mawhinney
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Vice President, Chief Financial<BR>
  Officer and
  Treasurer (Principal<BR>
  Accounting and Financial<br>
  Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March&nbsp;16, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Patrick Zenner
  <HR size="1" noshade color="#000000">
  Patrick Zenner
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chairman of the Board&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March&nbsp;16, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Laura Avakian
  <HR size="1" noshade color="#000000">
  Laura Avakian
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March&nbsp;16, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Timothy C. Barabe
  <HR size="1" noshade color="#000000">
  Timothy C. Barabe
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March&nbsp;16, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Werner Cautreels
  <HR size="1" noshade color="#000000">
  Werner Cautreels
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March&nbsp;16, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Tuan Ha-Ngoc
  <HR size="1" noshade color="#000000">
  Tuan Ha-Ngoc
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March&nbsp;16, 2005</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ William Messenger
  <HR size="1" noshade color="#000000">
  William Messenger
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">March&nbsp;16, 2005</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "INDEX TO EXHIBITS" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <P align="left" style="font-size: 10pt"><B><U>INDEX TO EXHIBITS</U></B>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="13%">&nbsp;</TD>
      <TD width="0%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">ArQule, Inc. Amended and Restated 1996 Director Stock Option
  Plan, as amended, filed herewith.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Robert J. Connaughton, Jr., filed herewith.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Robert J. Connaughton, Jr., included in the
  opinion filed as Exhibit&nbsp;5 hereto.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, filed herewith.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Exhibit&nbsp;24
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Powers of Attorney of certain officers and directors of
  ArQule, Inc., filed herewith.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER THE SECURITIES ACT OF 1933
  ARQULE, INC.
  (Exact Name of registrant as specified in its charter)
  Delaware
  58-1959440
  (State or other jurisdiction of
  (I.R.S. Employer
  incorporation or organization)
  Identification No.)
  19 Presidential Way,
  Woburn, Massachusetts 01801
  (Address, including zip code, of principal executive offices)
  ArQule, Inc. Amended and Restated 1996 Director Stock Option Plan
  (Full title of the plan)
  Dr. Stephen A. Hill
  President and Chief Executive Officer
  ArQule, Inc.
  19 Presidential Way,
  Woburn, Massachusetts 01801
  (781) 994-0300
  (Name, address, including zip code, and telephone number including area code, of agent for service)
  Copy to:
  Richard E. Baltz, Esq.
  Arnold & Porter
  555 12
  th
  Street, N.W.
  Washington, D.C. 20004
  (202) 942-5124
  Calculation of Registration Fee
  Proposed
  maximum offering
  Proposed maximum
  Title of securities to be
  Amount to be
  price per unit
  aggregate offering
  Amount of
  registered
  registered (1)
  (2)(3)
  price (3)
  registration fee
  Common Stock,
  $.01 par value
  60,000
  $5.02
  $301,200
  $35.45
  (1)
  Pursuant to Rule 416, promulgated under the Securities Act of 1933, as amended, an
  additional undeterminable number of shares of Common Stock is being registered to cover any
  adjustment in the number of shares of Common Stock issuable pursuant to the anti-dilution
  provisions of the Amended and Restated 1996 Director Stock Option Plan.
  (2)
  Calculated on the basis of the average of the high and low sale prices of the Registrant's
  Common Stock as reported on April 6, 2005 on the Nasdaq National Market which date is within 5
  business days prior to the date of the filing of this Registration Statement.
  (3)
  Estimated solely for the purpose of determining the registration fee in accordance with Rule
  457(h).
  The prospectus which will be part of this registration statement is a combined prospectus
  under SEC Rule 429 intended to be used for the offering of (a) the shares of the Company's Common
  Stock registered hereunder, and (b) the shares of the Company's Common Stock remaining to be issued
  which have been previously registered by Registration Statements on Form S-8 File Nos. 333-25369,
  333-43046, and 333-105297.
  TABLE OF CONTENTS
  EXPLANATORY NOTE AND INCORPORATION BY REFERENCE +
  PART II
  Item 3. Incorporation of Documents by Reference.
  Item 8. Exhibits
  SIGNATURES
  INDEX TO EXHIBITS
  EX-4 ArQule, Inc. Amended and Restated 1996 Director Stock Option Plan, as amended
  EX-5 Opinion of Robert J. Connaughton, Jr., filed herewith
  EX-23.2 Consent of PricewaterhouseCoopers LLP, filed herewith
  EX-24 Powers of Attorney of certain officers and directors of ArQule, Inc., filed herewith
  Table of Contents
  EXPLANATORY NOTE AND INCORPORATION BY REFERENCE
  This Registration Statement registers additional securities of the same class as other
  securities for which a registration statement filed on Form S-8 relating to the ArQule, Inc. (the
  "Company") Amended and Restated 1996 Director Stock Option Plan (the "Plan") is already effective.
  In accordance with General Instruction E to Form S-8, the contents of (i) the Company's
  Registration Statement on Form S-8 (File No. 333-25369) filed with the Securities Exchange
  Commission (the "Commission") on April 17, 1997, relating to the registration of 125,000 shares of
  the Company's common stock, $.01 par value per share (the "Common Stock") authorized for issuance
  under the Plan, (ii) the Company's Registration Statement on Form S-8 (File No. 333-43046) filed
  with the Commission on August 4, 2000, relating to the registration of 65,500 shares of Common
  Stock authorized for issuance under the Plan, and (iii) the Company's Registration Statement on
  Form S-8 (File No. 333-105297) filed with the Commission on May 15, 2003, relating to the
  registration of 100,000 shares of Common Stock authorized for issuance under the Plan are
  incorporated by reference in their entirety in this Registration Statement.
  This Registration Statement provides for the registration of an additional 60,000 shares of
  Common Stock authorized for issuance under the Plan.
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.      Incorporation of Documents by Reference.
  The following documents filed by the Company (File No. 000-20713) with the Commission under
  the Securities Exchange Act of 1934, as amended ("Exchange Act"), are incorporated herein by
  reference:
  (a)
  The Company's Annual Report on Form 10-K for the year ended December 31, 2004, filed with the
  Commission on March 16, 2005.
  (b)
  The description of the Company's Common Stock contained in a registration statement on Form
  8-A filed with the Commission on September 25, 1996, and any amendments or reports filed for
  the purpose of updating such description.
  All documents filed by the Registrant after the date of this Registration Statement pursuant
  to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
  amendment which indicates that all Common Stock offered hereby has been sold or which deregisters
  such Common Stock then remaining unsold, shall be deemed to be incorporated in this Registration
  Statement by reference and shall be a part hereof from the date of filing of such documents. Any
  statement contained in a document incorporated or deemed to be incorporated by reference in this
  Registration Statement shall be deemed to be modified or superseded for purposes of this
  Registration Statement to the extent that a statement contained herein or in any other subsequently
  filed document which also is or is deemed to be incorporated by reference in this Registration
  Statement modifies or supersedes such statement. Any such statement so modified or superseded
  shall not be deemed, except as so modified or so superseded, to constitute a part of this
  Registration Statement.
  Item 8. Exhibits
  Exhibit 4
  ArQule, Inc. Amended and Restated 1996 Director Stock Option Plan, as amended.
  Exhibit 5
  Opinion of Robert J. Connaughton, Jr., filed herewith.
  Exhibit 23.1
  Consent of Robert J. Connaughton, Jr., included in the
  opinion filed as Exhibit 5 hereto.
  Exhibit 23.2
  Consent of PricewaterhouseCoopers LLP, filed herewith.
  Exhibit 24
  Powers of Attorney of certain officers and directors of ArQule, Inc., filed herewith.
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the Company certifies
  that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned
  thereunto duly authorized in the City of Woburn, State of Massachusetts, on March 16, 2005.
  ARQULE, INC.
  By:
  /s/ Stephen A. Hill
  Stephen A. Hill
  President and Chief Executive Officer
  Pursuant to the requirements of the Securities Act of 1933, as amended, this registration
  statement has been signed by the following persons in the capacities and on the dates indicated:
  Signature
  Title
  Date
  /s/ Stephen A. Hill
  Stephen A. Hill
  President, Chief Executive
  Officer and Director
  (Principal
  Executive Officer)
  March 16, 2005
  /s/ Louise A. Mawhinney
  Louise A. Mawhinney
  Vice President, Chief Financial
  Officer and
  Treasurer (Principal
  Accounting and Financial
  Officer)
  March 16, 2005
  /s/ Patrick Zenner
  Patrick Zenner
  Chairman of the Board
  March 16, 2005
  /s/ Laura Avakian
  Laura Avakian
  Director
  March 16, 2005
  /s/ Timothy C. Barabe
  Timothy C. Barabe
  Director
  March 16, 2005
  /s/ Werner Cautreels
  Werner Cautreels
  Director
  March 16, 2005
  /s/ Tuan Ha-Ngoc
  Tuan Ha-Ngoc
  Director
  March 16, 2005
  /s/ William Messenger
  William Messenger
  Director
  March 16, 2005
  Table of Contents
  INDEX TO EXHIBITS
  Exhibit 4
  ArQule, Inc. Amended and Restated 1996 Director Stock Option
  Plan, as amended, filed herewith.
  Exhibit 5
  Opinion of Robert J. Connaughton, Jr., filed herewith.
  Exhibit 23.1
  Consent of Robert J. Connaughton, Jr., included in the
  opinion filed as Exhibit 5 hereto.
  Exhibit 23.2
  Consent of PricewaterhouseCoopers LLP, filed herewith.
  Exhibit 24
  Powers of Attorney of certain officers and directors of
  ArQule, Inc., filed herewith.