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  <TITLE>Aspect Medical Systems, Inc.</TITLE>
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <P align="center" style="font-size: 10pt">As filed with the Securities and Exchange Commission on May&nbsp;9, 2005
  
  
  
  <P align="left" style="font-size: 10pt; margin-left: 70%">Registration No.&nbsp;333-&#95;&#95;&#95;
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
  </DIV>
  
  <P align="center" style="font-size: 18pt"><B>FORM S-8</B>
  
  
  <P align="center" style="font-size: 12pt"><B>REGISTRATION STATEMENT UNDER<BR>
  THE SECURITIES ACT OF 1933</B>
  
  <P align="center" style="font-size: 24pt"><B>ASPECT MEDICAL SYSTEMS,
  INC.</B>
  
  <DIV align="center" style="font-size: 10pt">(Exact Name of Registrant
  as Specified in Its Charter)</DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
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      <TD width="47%">&nbsp;</TD>
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      <TD width="47%">&nbsp;</TD>
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  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-2985553</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or Other Jurisdiction of
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Incorporation or Organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Identification No.)</TD>
  </TR>
  <!-- End Table Body -->
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  </DIV>
  
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  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
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  <TR valign="bottom">
      <TD align="center" valign="top"><B>141 Needham Street, Newton, Massachusetts</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>02464-1505</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(Address of Principal Executive Offices)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(Zip Code)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><B>2001 STOCK INCENTIVE PLAN</B><BR>
  (Full Title of the Plan)
  
  
  
  <P align="center" style="font-size: 10pt"><B>Nassib G. Chamoun<BR>
  President and Chief Executive Officer<BR>
  Aspect Medical Systems, Inc.<BR>
  141 Needham Street<BR>
  Newton, Massachusetts 02464-1505</B><BR>
  (Name and Address of Agent For Service)
  
  
  
  <P align="center" style="font-size: 10pt"><B>(617)&nbsp;559-7700</B><BR>
  (Telephone Number, Including Area Code, of Agent For Service)
  
  
  
  <P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>
  
  
  <P>
  <DIV style="width: 100%; border: 3px double black; padding: 1px;">
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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      <TD width="1%">&nbsp;</TD>
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      <TD width="1%">&nbsp;</TD>
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      <TD width="1%">&nbsp;</TD>
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      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Proposed</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Proposed</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Maximum</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Maximum</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Title of Securities</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Amount to be</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Offering Price Per</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Aggregate</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Amount of</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">to be Registered</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Registered(1)</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Share</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Offering Price</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Registration Fee</TD>
      <TD>&nbsp;</TD>
  </TR>
  
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      <TD colspan="1" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD>Common Stock, $0.01
  par value per share
  (including the
  associated Series&nbsp;A
  Junior
  Participating
  Preferred Stock
  purchase
  rights)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" align="center" nowrap>2,000,000 shares</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">$</TD>
      <TD align="right">26.71</TD>
      <TD nowrap>(2)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">$</TD>
      <TD align="right">53,420,000</TD>
      <TD nowrap>(2)</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">6,287.54</TD>
      <TD>&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  </DIV>
  
  
  
  <P>
  <HR size="1" width="18%" align="left" noshade color="#000000">
  
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  <TR valign="top">
      <TD width="1%" nowrap align="left">(1)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">In accordance with Rule&nbsp;416 under the Securities Act of 1933, as amended, this registration
  statement shall be deemed to cover any additional securities that may from time to time be
  offered or issued to prevent dilution resulting from stock splits, stock dividends or similar
  transactions.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="left">(2)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c)
  and 457(h) of the Securities Act of 1933, as amended, and based upon the average of the high
  and low prices of the Registrant&#146;s Common Stock as reported on the Nasdaq National Market on
  May&nbsp;5, 2005.</TD>
  </TR>
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
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  </TR>
  <TR><TD colspan="9"><A HREF="#000"> Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#001"> Item&nbsp;8. Exhibits.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#002"> SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003"> INDEX TO EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55044amexv5w1.htm">EX-5.1 Opinion of Wilmer, Cutler, Pickering, Hale and Dorr LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b55044amexv23w2.htm">EX-23.2 Consent of Ernst & Young LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  <P align="left" style="font-size: 10pt"><B>Statement of Incorporation by Reference</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This registration statement on Form S-8 is filed to register the offer and sale of an
  additional 2,000,000 shares of the Registrant&#146;s Common Stock, $0.01 par value per share, to be
  issued under the 2001 Stock Incentive Plan of Aspect Medical Systems, Inc. This registration
  statement incorporates by reference the contents of the registration statement on Form S-8, File
  No.&nbsp;333-86048, filed by the Registrant on April&nbsp;11, 2002 relating to the Registrant&#146;s 2001 Stock
  Incentive Plan, except for Item&nbsp;5, Interests of Named Experts and Counsel, and Item&nbsp;8, Exhibits.
  
  <!-- link1 " Item&nbsp;5. Interests of Named Experts and Counsel." -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Wilmer, Cutler, Pickering, Hale and Dorr LLP has opined as to the legality of the securities
  being offered by this registration statement. Certain attorneys at Wilmer, Cutler, Pickering, Hale
  and Dorr LLP own shares of the Registrant&#146;s common stock.
  
  <!-- link1 " Item&nbsp;8. Exhibits." -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Item&nbsp;8. Exhibits.</B>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Exhibit&nbsp;Index immediately preceding the exhibits is incorporated herein by reference.
  
  
  <P align="center" style="font-size: 10pt">- 1 -
  </DIV>
  
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  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 " SIGNATURES" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>SIGNATURES</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this registration statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Newton, Massachusetts, on this 9<SUP style="font-size: 85%; vertical-align: text-top">th</SUP> day of May, 2005.
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">ASPECT MEDICAL SYSTEMS, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Nassib G. Chamoun
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Nassib G. Chamoun&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">President and Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY AND SIGNATURES</B>
  
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We, the undersigned officers and directors of Aspect Medical Systems, Inc., hereby severally
  constitute and appoint Nassib G. Chamoun, J. Breckenridge Eagle and Michael Falvey, and each of
  them singly, our true and lawful attorneys with full power to them, and each of them singly, to
  sign for us and in our names in the capacities indicated below, the registration statement on Form
  S-8 filed herewith and any and all subsequent amendments to said registration statement, and
  generally to do all such things in our names and on our behalf in our capacities as officers and
  directors to enable Aspect Medical Systems, Inc. to comply with the provisions of the Securities
  Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby
  ratifying and confirming our signatures as they may be signed by our said attorneys, or any of
  them, to said registration statement and any and all amendments thereto.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this registration statement has
  been signed by the following persons in the capacities and on the dates indicated.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
      <TD width="20%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Nassib G. Chamoun
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">President, Chief Executive
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;9, 2005</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="1" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Nassib G. Chamoun
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Officer and Director (Principal
  Executive Officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ J. Breckenridge Eagle
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chairman of the Board of Directors
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;9, 2005</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="1" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">J. Breckenridge Eagle</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Michael Falvey
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Vice President and Chief
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;9, 2005</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="1" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Michael Falvey
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Financial Officer (Principal</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Financial and Accounting Officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Edwin M. Kania
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;9, 2005</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="1" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Edwin M. Kania</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">- 2 -
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
      <TD width="20%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ James J. Mahoney, Jr.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;9, 2005</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="1" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">James J. Mahoney, Jr.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Richard J. Meelia
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;9, 2005</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="1" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Richard J. Meelia</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Donald R. Stanski
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;9, 2005</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="1" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Donald R. Stanski, M.D.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ David Feigal
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;9, 2005</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="1" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">David Feigal, M.D.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">May&nbsp;9, 2005</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD colspan="1" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
  
  <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Boudewijn
  L.P.M. Bollen</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">- 3 -
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <!-- link1 " INDEX TO EXHIBITS" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  <P align="center" style="font-size: 10pt"><B>INDEX TO EXHIBITS</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="6%">&nbsp;</TD>
      <TD width="4%">&nbsp;</TD>
      <TD width="90%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1(1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2(2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated By-Laws of the Registrant</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3(3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement dated November&nbsp;29, 2004 between the Registrant and
  EquiServe Trust Company, N.A., as rights agent</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Wilmer, Cutler, Pickering, Hale and Dorr LLP, counsel to
  the Registrant</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Wilmer, Cutler, Pickering, Hale and Dorr LLP
  (included in Exhibit&nbsp;5.1)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of attorney (included on the signature pages of this
  registration statement)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P>
  <HR size="1" width="18%" align="left" noshade color="#000000">
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top">
      <TD width="1%" nowrap align="left">(1)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed with the Securities and Exchange Commission as Exhibit&nbsp;3.1 to the
  Registrant&#146;s Registration Statement on Form S-1, as amended (File No.&nbsp;333-86295), and
  incorporated herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="left">(2)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed with the Securities and Exchange Commission as Exhibit&nbsp;3.1 to the
  Registrant&#146;s Quarterly Report on Form 10-Q for the period ended March&nbsp;31, 2001 (File No.
  000-24663), and incorporated herein by reference.</TD>
  </TR>
  
  <TR><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD width="1%" nowrap align="left">(3)</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="96%">Previously filed with the Securities and Exchange Commission as Exhibit&nbsp;4.1 to the
  Registrant&#146;s Current Report on Form 8-K filed on December&nbsp;1, 2004 (File No.&nbsp;000-24663), and
  incorporated herein by reference.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  </BODY>
  </HTML>
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text: Aspect Medical Systems, Inc.
  Table of Contents
  As filed with the Securities and Exchange Commission on May 9, 2005
  Registration No. 333-___
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER
  THE SECURITIES ACT OF 1933
  ASPECT MEDICAL SYSTEMS,
  INC.
  (Exact Name of Registrant
  as Specified in Its Charter)
  Delaware
  04-2985553
  (State or Other Jurisdiction of
  (I.R.S. Employer
  Incorporation or Organization)
  Identification No.)
  141 Needham Street, Newton, Massachusetts
  02464-1505
  (Address of Principal Executive Offices)
  (Zip Code)
  2001 STOCK INCENTIVE PLAN
  (Full Title of the Plan)
  Nassib G. Chamoun
  President and Chief Executive Officer
  Aspect Medical Systems, Inc.
  141 Needham Street
  Newton, Massachusetts 02464-1505
  (Name and Address of Agent For Service)
  (617) 559-7700
  (Telephone Number, Including Area Code, of Agent For Service)
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  Maximum
  Maximum
  Title of Securities
  Amount to be
  Offering Price Per
  Aggregate
  Amount of
  to be Registered
  Registered(1)
  Share
  Offering Price
  Registration Fee
  Common Stock, $0.01
  par value per share
  (including the
  associated Series A
  Junior
  Participating
  Preferred Stock
  purchase
  rights)
  2,000,000 shares
  $
  26.71
  (2)
  $
  53,420,000
  (2)
  $
  6,287.54
  (1)
  In accordance with Rule 416 under the Securities Act of 1933, as amended, this registration
  statement shall be deemed to cover any additional securities that may from time to time be
  offered or issued to prevent dilution resulting from stock splits, stock dividends or similar
  transactions.
  (2)
  Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c)
  and 457(h) of the Securities Act of 1933, as amended, and based upon the average of the high
  and low prices of the Registrant's Common Stock as reported on the Nasdaq National Market on
  May 5, 2005.
  TABLE OF CONTENTS
  Item 5. Interests of Named Experts and Counsel.
  Item 8. Exhibits.
  SIGNATURES
  INDEX TO EXHIBITS
  EX-5.1 Opinion of Wilmer, Cutler, Pickering, Hale and Dorr LLP
  EX-23.2 Consent of Ernst & Young LLP
  Table of Contents
  Statement of Incorporation by Reference
  This registration statement on Form S-8 is filed to register the offer and sale of an
  additional 2,000,000 shares of the Registrant's Common Stock, $0.01 par value per share, to be
  issued under the 2001 Stock Incentive Plan of Aspect Medical Systems, Inc. This registration
  statement incorporates by reference the contents of the registration statement on Form S-8, File
  No. 333-86048, filed by the Registrant on April 11, 2002 relating to the Registrant's 2001 Stock
  Incentive Plan, except for Item 5, Interests of Named Experts and Counsel, and Item 8, Exhibits.
  Item 5. Interests of Named Experts and Counsel.
  Wilmer, Cutler, Pickering, Hale and Dorr LLP has opined as to the legality of the securities
  being offered by this registration statement. Certain attorneys at Wilmer, Cutler, Pickering, Hale
  and Dorr LLP own shares of the Registrant's common stock.
  Item 8. Exhibits.
  The Exhibit Index immediately preceding the exhibits is incorporated herein by reference.
  - 1 -
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this registration statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Newton, Massachusetts, on this 9
  th
  day of May, 2005.
  ASPECT MEDICAL SYSTEMS, INC.
  By:
  /s/ Nassib G. Chamoun
  Nassib G. Chamoun
  President and Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  We, the undersigned officers and directors of Aspect Medical Systems, Inc., hereby severally
  constitute and appoint Nassib G. Chamoun, J. Breckenridge Eagle and Michael Falvey, and each of
  them singly, our true and lawful attorneys with full power to them, and each of them singly, to
  sign for us and in our names in the capacities indicated below, the registration statement on Form
  S-8 filed herewith and any and all subsequent amendments to said registration statement, and
  generally to do all such things in our names and on our behalf in our capacities as officers and
  directors to enable Aspect Medical Systems, Inc. to comply with the provisions of the Securities
  Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby
  ratifying and confirming our signatures as they may be signed by our said attorneys, or any of
  them, to said registration statement and any and all amendments thereto.
  Pursuant to the requirements of the Securities Act of 1933, this registration statement has
  been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Nassib G. Chamoun
  President, Chief Executive
  May 9, 2005
  Nassib G. Chamoun
  Officer and Director (Principal
  Executive Officer)
  /s/ J. Breckenridge Eagle
  Chairman of the Board of Directors
  May 9, 2005
  J. Breckenridge Eagle
  /s/ Michael Falvey
  Vice President and Chief
  May 9, 2005
  Michael Falvey
  Financial Officer (Principal
  Financial and Accounting Officer)
  /s/ Edwin M. Kania
  Director
  May 9, 2005
  Edwin M. Kania
  - 2 -
  Table of Contents
  Signature
  Title
  Date
  /s/ James J. Mahoney, Jr.
  Director
  May 9, 2005
  James J. Mahoney, Jr.
  /s/ Richard J. Meelia
  Director
  May 9, 2005
  Richard J. Meelia
  /s/ Donald R. Stanski
  Director
  May 9, 2005
  Donald R. Stanski, M.D.
  /s/ David Feigal
  Director
  May 9, 2005
  David Feigal, M.D.
  Director
  May 9, 2005
  Boudewijn
  L.P.M. Bollen
  - 3 -
  Table of Contents
  INDEX TO EXHIBITS
  Number
  Description
  4.1(1)
  Restated Certificate of Incorporation of the Registrant
  4.2(2)
  Amended and Restated By-Laws of the Registrant
  4.3(3)
  Rights Agreement dated November 29, 2004 between the Registrant and
  EquiServe Trust Company, N.A., as rights agent
  5.1
  Opinion of Wilmer, Cutler, Pickering, Hale and Dorr LLP, counsel to
  the Registrant
  23.1
  Consent of Wilmer, Cutler, Pickering, Hale and Dorr LLP
  (included in Exhibit 5.1)
  23.2
  Consent of Ernst & Young LLP
  24.1
  Power of attorney (included on the signature pages of this
  registration statement)
  (1)
  Previously filed with the Securities and Exchange Commission as Exhibit 3.1 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-86295), and
  incorporated herein by reference.
  (2)
  Previously filed with the Securities and Exchange Commission as Exhibit 3.1 to the
  Registrant's Quarterly Report on Form 10-Q for the period ended March 31, 2001 (File No.
  000-24663), and incorporated herein by reference.
  (3)
  Previously filed with the Securities and Exchange Commission as Exhibit 4.1 to the
  Registrant's Current Report on Form 8-K filed on December 1, 2004 (File No. 000-24663), and
  incorporated herein by reference.