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  <P align="center"><FONT size="2"><B>As filed with the Securities and Exchange Commission on June&nbsp;14, 2002</B>
  </FONT>
  
  <P align="right"><FONT size="2"><B>REGISTRATION NO. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B>
  </FONT>
  
  <HR size="4" noshade color="#000000" style="margin-top: -5px">
  <HR size="1" noshade color="#000000" style="margin-top: -10px">
  
  
  
  
  <P align="center"><FONT size="4"><B>SECURITIES AND EXCHANGE
  COMMISSION</B></FONT><BR>
  <B><FONT size="2">WASHINGTON, D.C. 20549</FONT></B>
  
  
  <P>
  <HR width="26%" align="center" size="1" noshade>
  <P>
  
  
  <P align="center"><FONT size="5"><B>FORM S-8</B></FONT><BR>
  <FONT size="2"><B>REGISTRATION STATEMENT<BR>
  under the<BR>
  SECURITIES ACT OF 1933</B></FONT>
  
  
  <P>
  <HR width="26%" align="center" size="1" noshade>
  <P>
  
  
  <P align="center"><FONT size="5"><B>ARIAD PHARMACEUTICALS, INC.</B></FONT><BR>
  <FONT size="2"><I>(Exact name of Registrant as specified in its
  charter)</I>
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="55%">
  <TR valign="bottom">
          <TD width="50%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="45%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD align="center" valign="top"><FONT size="2"><B>Delaware</B><BR>
  (<I>State or other jurisdiction<BR>
  of incorporation or organization</I>)</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="center" valign="top"><FONT size="2">
  <B>22-3106987</B><BR>
  (<I>I.R.S. Employer<BR>
  Identification No.</I>)</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2"><B>26 Landsdowne Street<BR>
  Cambridge, Massachusetts 02139<BR>
  (617)&nbsp;494-0400</B><BR>
  <I>(Address of Principal Executive Offices)</I>
  </FONT>
  
  <P align="center"><FONT size="2"><B>THE ARIAD PHARMACEUTICALS, INC.<BR>
  2001 STOCK PLAN, AS AMENDED</B>
  </FONT>
  
  <P align="center"><FONT size="2"><B>Harvey J. Berger, M.D.<BR>
  President and Chief Executive Officer<BR>
  ARIAD Pharmaceuticals, Inc.<BR>
  26 Landsdowne Street<BR>
  Cambridge, Massachusetts 02139-4234<BR>
  (617)&nbsp;494-0400</B><BR>
  <I>(Name, address, including zip code, and telephone number, including area<BR>
  code, of agent for service)</I>
  </FONT>
  
  <P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B>
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
          <TD width="35%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="1%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="1%">&nbsp;</TD>
          <TD width="1%">&nbsp;</TD>
          <TD width="2%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="6%">&nbsp;</TD>
          <TD width="1%">&nbsp;</TD>
          <TD width="6%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="3%">&nbsp;</TD>
          <TD width="1%">&nbsp;</TD>
          <TD width="3%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
  <TD colspan="17"><HR size="4" noshade></TD>
  </TR>
  <TR valign="bottom">
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>maximum</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>maximum</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="center"><FONT size="1"><B>Title of</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount to be</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>offering price</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>aggregate</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="center"><FONT size="1"><B>securities to be registered</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>registered(1)</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>per share(2)</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>offering price(2)</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center" colspan="3"><FONT size="1"><B>registration fee</B></FONT></TD>
  </TR>
  <TR valign="bottom">
  <TD colspan="17"><HR size="1" noshade></TD>
  </TR>
  
  <TR valign="bottom">
          <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, $.001 par value</FONT></DIV></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="right"><FONT size="2">1,600,000</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="right"><FONT size="2">$</FONT></TD>
          <TD align="right"><FONT size="2">3.88</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="right"><FONT size="2">$</FONT></TD>
          <TD align="right"><FONT size="2">6,208,000</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="right"><FONT size="2">$</FONT></TD>
          <TD align="right"><FONT size="2">571.14</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
  <TD colspan="17"><HR size="4" noshade></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P>
  <HR size="1" width="18%" align="left" noshade>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR valign="top">
        <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
          <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
          <TD width="96%"><FONT size="2">The number of shares of common stock, par value $.001 per share (&#147;Common
  Stock&#148;), stated above consists of the aggregate number of additional
  shares not previously registered which may be sold upon the exercise of
  options which may hereafter be granted under The ARIAD Pharmaceuticals,
  Inc. 2001 Stock Plan, as amended (the &#147;Plan&#148;). The maximum number of
  shares which may be sold upon the exercise of such options granted under
  the Plan is subject to adjustment in accordance with certain anti-dilution
  and other provisions of the Plan. Accordingly, pursuant to Rule&nbsp;416 under
  the Securities Act of 1933, as amended (the &#147;Securities Act&#148;), this
  Registration Statement covers, in addition to the number of shares stated
  above, an indeterminate number of shares which may be subject to grant or
  otherwise issuable after the operation of any such anti-dilution and other
  provisions.</FONT></TD>
  </TR>
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
        <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
          <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
          <TD width="96%"><FONT size="2">This calculation is made solely for the purpose of determining the
  registration fee pursuant to the provisions of Rule&nbsp;457(h) under the
  Securities Act based on the average of the high and low sale prices per
  share of the Common Stock on the National Market System of the National
  Association of Securities Dealers Automated Quotation System (&#147;Nasdaq&#148;) as
  of a date (June&nbsp;10, 2002) within 5 business days prior to filing this
  Registration Statement. None of the shares being registered hereunder are
  subject to outstanding options.</FONT></TD>
  </TR>
  </TABLE>
  <P>
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  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
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  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">EXPLANATORY NOTE</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#001">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;3. Incorporation of Certain Documents by Reference.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;4. Description of Securities.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;6. Indemnification of Directors and Officers.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;7. Exemption from Registration Claimed.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;8. Exhibits.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#008">Item&nbsp;9. Undertakings.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#009">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#010">EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b43383arexv5w1.htm">Ex-5.1 Opinion and Consent of Mintz, Levin, Cohn..</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b43383arexv23w1.htm">Ex-23.1 Consent of Deloitte & Touche  LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b43383arexv99w1.htm">Ex-99.1 2001 Stock Plan, amended</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  
  <!-- link1 "EXPLANATORY NOTE" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  <P align="center"><FONT size="2"><B>EXPLANATORY NOTE</B>
  </FONT>
  
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with the instructional Note to Part I of Form&nbsp;S-8 as
  promulgated by the Securities and Exchange Commission, the information
  specified by Part I of Form&nbsp;S-8 has been omitted from this Registration
  Statement on Form&nbsp;S-8 for offers of Common Stock pursuant to the Plan. This
  Registration Statement on Form&nbsp;S-8 hereby registers 1,600,000 additional shares
  of Common Stock for issuance under the Plan. A Registration Statement on Form
  S-8 (File No.&nbsp;333-63706), registering an aggregate of 1,330,000 shares of
  Common Stock under the Plan, was filed with the Commission on June&nbsp;22, 2001.
  </FONT>
  <P align="center"><FONT size="2"></FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <!-- link1 "PART II" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  <P align="center"><FONT size="2"><B>PART II</B>
  </FONT>
  
  <P align="center"><FONT size="2"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  </FONT>
  
  <!-- link2 "Item&nbsp;3. Incorporation of Certain Documents by Reference." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;3. Incorporation of Certain Documents by Reference.</B>
  </FONT>
  
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Commission are
  incorporated herein by reference:
  </FONT>
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR>
          <TD width="2%"></TD>
          <TD width="3%"></TD>
          <TD width="95%"></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">(a)</FONT></TD>
          <TD><FONT size="2">The Registrant&#146;s Annual Report on Form&nbsp;10-K for the fiscal year
  ended December&nbsp;31, 2001;</FONT></TD>
  </TR>
  
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">(b)</FONT></TD>
          <TD><FONT size="2">The Registrant&#146;s Quarterly Report on Form&nbsp;10-Q for the fiscal
  quarter ended March&nbsp;31, 2002;</FONT></TD>
  </TR>
  
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">(c)</FONT></TD>
          <TD><FONT size="2">The Registrant&#146;s Definitive Proxy Statement filed on April&nbsp;24,
  2002;</FONT></TD>
  </TR>
  
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">(d)</FONT></TD>
          <TD><FONT size="2">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on April&nbsp;9,
  2002;</FONT></TD>
  </TR>
  
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">(e)</FONT></TD>
          <TD><FONT size="2">The description of the Common Stock contained in the
  Registrant&#146;s Registration Statement on Form&nbsp;10 (File No.&nbsp;0-21696)
  filed under the Securities Exchange Act of 1934 on June&nbsp;25, 1993,
  including any amendment or report filed for the purpose of updating
  such description; and</FONT></TD>
  </TR>
  
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">(f)</FONT></TD>
          <TD><FONT size="2">The description of the Preferred Shares Purchase Rights
  contained in the Registrant&#146;s Registration Statement on Form&nbsp;8-A
  (File No.&nbsp;0-21696) filed under the Securities and Exchange Act of
  1934 on June&nbsp;19, 2000, including any amendment or report filed for
  the purpose of updating such description.</FONT></TD>
  </TR>
  
  </TABLE>
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents filed by the Registrant after the date
  hereof pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Securities
  Exchange Act of 1934 prior to the filing of a post-effective amendment which
  indicates that all securities offered hereby have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be
  incorporated by reference herein and to be part hereof from the date of filing
  of such reports and documents.
  </FONT>
  <!-- link2 "Item&nbsp;4. Description of Securities." -->
  <DIV align="left"><A NAME="003"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;4. Description of Securities.</B>
  </FONT>
  
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </FONT>
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
  <DIV align="left"><A NAME="004"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  </FONT>
  
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the issuance of the shares of Common Stock registered
  under this Registration Statement has been passed upon for the Registrant by
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston, Massachusetts.
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm
  own an aggregate of approximately 11,500 shares of Common Stock of the
  Registrant.
  </FONT>
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers." -->
  <DIV align="left"><A NAME="005"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B>
  </FONT>
  
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(a) of the General Corporation Law of the State of Delaware
  provides that a Delaware corporation may indemnify any person who was or is a
  party or is threatened to be made a party to any threatened, pending or
  completed action, suit or proceeding, whether civil, criminal, administrative
  or investigative (other than an action by or in the right of the corporation)
  by reason of the fact that he is or was a director, officer, employee or agent
  of the corporation or is or was serving at the request of the corporation as a
  director, officer, employee or agent of another corporation or enterprise,
  against expenses, judgments, fines and amounts paid in settlement actually and
  reasonably incurred by him in connection with such action, suit or proceeding
  if he acted in good faith and in a manner he reasonably believed to be in or
  not opposed to the best interests of the corporation, and, with respect to any
  criminal action or proceeding, had no cause to believe his conduct was
  unlawful.
  </FONT>
  <P align="center"><FONT size="2"></FONT>
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  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(b) provides that a Delaware corporation may indemnify any
  person who was or is a party or is threatened to be made a party to any
  threatened, pending or completed action or suit by or in the right of the
  corporation to procure a judgment in its favor by reason of the fact that such
  person acted in any of the capacities set forth above, against expenses
  actually and reasonably incurred by him in connection with the defense or
  settlement of such action or suit if he acted under similar standards, except
  that no indemnification may be made in respect of any claim, issue or matter as
  to which such person shall have been adjudged to be liable to the corporation
  unless and only to the extent that the court in which such action or suit was
  brought shall determine that despite the adjudication of liability, such person
  is fairly and reasonably entitled to be indemnified for such expenses which the
  court shall
  deem proper.
  </FONT>
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 further provides that to the extent a director or officer of a
  corporation has been successful in the defense of any action, suit or
  proceeding referred to in subsections (a)&nbsp;and (b)&nbsp;or in the defense of any
  claim, issue or matter therein, he shall be indemnified against expenses
  actually and reasonably incurred by him in connection therewith; that
  indemnification provided for by Section&nbsp;145 shall not be deemed exclusive of
  any other rights to which the indemnified party may be entitled; and that the
  corporation may purchase and maintain insurance on behalf of a director or
  officer of the corporation against any liability asserted against him or
  incurred by him in any such capacity or arising out of his status as such
  whether or not the corporation would have the power to indemnify him against
  such liabilities under such Section&nbsp;145.
  </FONT>
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Certificate of Incorporation, as amended, and By-laws of the
  Registrant provide for indemnification of the Registrant&#146;s directors and
  officers to the fullest extent permitted by law. The By-laws also permit the
  Board of Directors to authorize the Registrant to purchase and maintain
  insurance against any liability asserted against any director, officer,
  employee or agent of the Registrant arising out of his capacity as such.
  Insofar as indemnification for liabilities under the Securities Act may be
  permitted to directors, officers, or controlling persons of the Registrant
  pursuant to the Registrant&#146;s Certificate of Incorporation, as amended, its
  By-laws and the Delaware General Corporation Law, the Registrant has been
  informed that in the opinion of the Commission such indemnification is against
  public policy as expressed in such Act and is therefore unenforceable.
  </FONT>
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As permitted by the Delaware General Corporation Law, the Registrant&#146;s
  Certificate of Incorporation, as amended, provides that directors of the
  Registrant shall not be personally liable to the Registrant or its stockholders
  for monetary damages for breach of fiduciary duty as a director, except for
  liability (i)&nbsp;for any breach of the director&#146;s duty of loyalty to the
  Registrant or its stockholders, (ii)&nbsp;for acts or omissions not in good faith or
  which involve intentional misconduct or a knowing violation of law, (iii)&nbsp;under
  Section&nbsp;174 of the Delaware General Corporation Law, relating to prohibited
  dividends or distributions or the repurchase or redemption of stock or (iv)&nbsp;for
  any transaction from which the director derives an improper personal benefit.
  As a result of this provision, the Registrant and its stockholders may be
  unable to obtain monetary damages from a director for breach of his or her duty
  of care.
  </FONT>
  <!-- link2 "Item&nbsp;7. Exemption from Registration Claimed." -->
  <DIV align="left"><A NAME="006"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;7. Exemption from Registration Claimed.</B>
  </FONT>
  
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </FONT>
  <P align="center"><FONT size="2">II-2</FONT>
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  <!-- link2 "Item&nbsp;8. Exhibits." -->
  <DIV align="left"><A NAME="007"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits.</B>
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="90%">
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="left"><FONT size="1"><B>Exhibit</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="left"><FONT size="1"><B>Number</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center"><FONT size="1"><B>Description</B></FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="center"><HR size="1" noshade></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Form of Common Stock Certificate (filed as an exhibit to
  the Registrant&#146;s Registration Statement on Form&nbsp;10, file number
  000-21696, filed with the Securities and Exchange Commission on
  June&nbsp;25, 1993 and incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.2</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Certificate of Incorporation, as amended (filed as Exhibit
  3.1 to the Registrant&#146;s Registration Statement on Form&nbsp;10, file
  number 000-21696, filed with the Securities and Exchange Commission
  on June&nbsp;25, 1993 and incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.3</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Amendment of Certificate of Incorporation dated April&nbsp;8,
  1994 (filed as Exhibit&nbsp;3.3 to the Registrant&#146;s Annual Report on
  Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 1993 filed with
  the Securities and Exchange Commission on April&nbsp;15, 1994 and
  incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.4</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Amendment of Certificate of Incorporation dated October&nbsp;4,
  1994 (filed as Exhibit&nbsp;3.4 to the Registrant&#146;s Annual Report on
  Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 1994 filed with
  the Securities and Exchange Commission on March&nbsp;30, 1995 and
  incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.5</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Restated By-laws, as amended (filed as Exhibit&nbsp;4.2 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-3, file number
  333-38664, filed with the Securities and Exchange Commission on
  June&nbsp;23, 2000 and incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.6</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Rights Agreement, dated as of June&nbsp;8, 2000, between the
  Registrant and State Street Bank and Trust Company, which includes
  the Form of Certificate of Designations in respect of the Series&nbsp;A
  Preferred Stock, as Exhibit&nbsp;A, the Form of Right Certificate as
  Exhibit&nbsp;B and the Summary of Rights to Purchase Series&nbsp;A Preferred
  Stock as Exhibit&nbsp;C (filed as Exhibit&nbsp;1 to the Registrant&#146;s
  Registration Statement on Form&nbsp;8-A, file number 000-21696, filed
  with the Securities and Exchange Commission on June&nbsp;19, 2000 and
  incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">5.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C., as to the legality of the shares being registered.</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">23.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Consent of Deloitte &#038; Touche LLP</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">23.2</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  (filed with Exhibit&nbsp;5.1)</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">24.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Power of Attorney (included on signature page).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">99.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  ARIAD Pharmaceuticals, Inc. 2001 Stock Plan, as amended.</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <!-- link2 "Item&nbsp;9. Undertakings." -->
  <DIV align="left"><A NAME="008"></A></DIV>
  <P align="left"><FONT size="2"><B>Item&nbsp;9. Undertakings.</B>
  </FONT>
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR valign="top">
          <TD width="1%" align="left" nowrap><FONT size="2">(a)</FONT></TD>
          <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
          <TD width="96%"><FONT size="2">The undersigned Registrant hereby undertakes:</FONT></TD>
  </TR>
  </TABLE>
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR>
          <TD width="3%"></TD>
          <TD width="97%"></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:</FONT></TD>
  </TR>
  
  </TABLE>
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR>
          <TD width="6%"></TD>
          <TD width="94%"></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;To include any prospectus required by Section&nbsp;10(a)(3) of
  the Securities Act of 1933;</FONT></TD>
  </TR>
  
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;To reflect in the prospectus any facts or events arising
  after the effective date of the Registration Statement (or the most
  recent post-effective amendment thereof) which, individually or in the</FONT></TD>
  </TR>
  
  </TABLE>
  <P align="center"><FONT size="2">II-3</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR>
          <TD width="6%"></TD>
          <TD width="94%"></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">aggregate, represents a fundamental change in the information
  set forth in the Registration Statement. Notwithstanding the
  foregoing, any increase or decrease in volume of securities offered
  (if the total dollar value of securities offered would not exceed
  that which was registered) and any deviation from the low or high
  end of the estimated maximum offering range may be reflected in the
  form of prospectus filed with the Commission pursuant to Rule&nbsp;424(b)
  (Section&nbsp;230.424(b) of this chapter) if, in the aggregate, the
  changes in volume and price represent no more than a 20% change in
  the maximum aggregate offering price set forth in the &#147;Calculation
  of Registration Fee&#148; table in the effective Registration Statement;</FONT></TD>
  </TR>
  
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;To include any material information with respect to the
  plan of distribution not previously disclosed in the Registration
  Statement or any material change to such information in the
  Registration Statement;</FONT></TD>
  </TR>
  
  </TABLE>
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR>
          <TD width="4%"></TD>
          <TD width="96%"></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2"><I>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Provided, however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
  apply if the information required to be included in a post-effective
  amendment by those paragraphs is contained in periodic reports filed by
  the Registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d) of the Securities
  Exchange Act of 1934 that are incorporated by reference in this
  Registration Statement.</FONT></TD>
  </TR>
  
  </TABLE>
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR>
          <TD width="4%"></TD>
          <TD width="96%"></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">(2)&nbsp;That, for the purpose of determining any liability under the
  Securities Act of 1933, each such post-effective amendment shall be deemed
  to be a new registration statement relating to the securities offered
  therein, and the offering of such securities at that time shall be deemed
  to be the initial bona fide offering thereof.</FONT></TD>
  </TR>
  
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD><FONT size="2">(3)&nbsp;To remove from registration by means of a post-effective amendment any
  of the securities being registered which remain unsold at the termination
  of the offering.</FONT></TD>
  </TR>
  
  </TABLE>
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR valign="top">
          <TD width="1%" align="left" nowrap><FONT size="2">(b)</FONT></TD>
          <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
          <TD width="96%"><FONT size="2">The undersigned Registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act of 1933, each filing of
  the Registrant&#146;s annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d)
  of the Securities Exchange Act of 1934 that is incorporated by reference
  in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of
  such securities at that time shall be deemed to be the initial bona fide
  offering thereof.</FONT></TD>
  </TR>
  <TR>
          <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
          <TD width="1%" align="left" nowrap><FONT size="2">(c)</FONT></TD>
          <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
          <TD width="96%"><FONT size="2">Insofar as indemnification for liabilities arising under the Securities
  Act of 1933 may be permitted to directors, officers and controlling
  persons of the Registrant pursuant to the foregoing provisions, or
  otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public
  policy as expressed in the Act and is, therefore, unenforceable. In the
  event that a claim for indemnification against such liabilities (other
  than the payment by the Registrant of expenses incurred or paid by a
  director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such
  director, officer or controlling person in connection with the securities
  being registered, the Registrant will, unless in the opinion of its
  counsel the matter has been settled by controlling precedent, submit to a
  court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Act and
  will be governed by the final adjudication of such issue.</FONT></TD>
  </TR>
  </TABLE>
  <P align="center"><FONT size="2">II-4</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="009"></A></DIV>
  <P align="center"><FONT size="2"><B>SIGNATURES</B>
  </FONT>
  
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>The Registrant.</I> Pursuant to the requirements of the Securities Act of
  1933, the Registrant certifies that it has reasonable grounds to believe that
  it meets all of the requirements for filing on Form&nbsp;S-8 and has duly caused
  this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Cambridge, Massachusetts on June&nbsp;14, 2002.
  </FONT>
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR valign="top">
          <TD width="50%"><FONT size="2">&nbsp;</FONT></TD>
          <TD width="50%"><FONT size="2">ARIAD PHARMACEUTICALS, INC.</FONT></TD>
  </TR>
  </TABLE>
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
  <TR valign="top">
          <TD width="50%"><FONT size="2">&nbsp;</FONT></TD>
          <TD width="50%"><FONT size="2">By: /s/ Harvey J. Berger<BR>
  &#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
  Harvey J. Berger, M.D.<BR>
  President and Chief Executive Officer</FONT></TD>
  </TR>
  </TABLE>
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Harvey
  J. Berger and Edward M. Fitzgerald, and each of them, his true and lawful
  attorneys-in-fact and agents, with full power of substitution and
  resubstitution in each of them, for him and in his name, place and stead, and
  in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement on Form&nbsp;S-8 of ARIAD
  Pharmaceuticals, Inc., or any other registration statement for the same
  offering that is to be effective upon filing pursuant to Rule&nbsp;462(b) under the
  Securities Act of 1933, as amended, and to file the same, with all exhibits
  thereto and other documents in connection therewith, with the Securities and
  Exchange Commission, granting unto said attorneys-in-fact and agents, and each
  of them, full power and authority to do and perform each and every act and
  thing requisite or necessary to be done in or about the premises, as full to
  all intents and purposes as he might or could do in person, hereby ratifying
  and confirming all that said attorneys-in-fact and agents or any of them or
  their or his substitute or substitutes may lawfully do or cause to be done by
  virtue hereof.
  </FONT>
  <P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed by the following persons in the
  capacities and on the dates indicated.
  </FONT>
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
  <TR valign="bottom">
          <TD width="29%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="41%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="20%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="left"><FONT size="1"><B>Signature</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="left"><FONT size="1"><B>Title</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="left"><FONT size="1"><B>Date</B></FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="center"><HR size="1" noshade></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center"><HR size="1" noshade></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
          <TD>&nbsp;</TD>
          <TD>&nbsp;</TD>
          <TD>&nbsp;</TD>
          <TD>&nbsp;</TD>
          <TD>&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">/s/ Harvey J. Berger<BR>
  </FONT><HR size="1" noshade><FONT size="2">
  Harvey J. Berger, M.D.</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Chairman of the Board,<BR>
  President and Chief Executive Officer<BR>
  (principal executive officer)
  </FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">June 14, 2002</FONT></TD>
  </TR>
  <TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">/s/ Edward M. Fitzgerald<BR>
  </FONT><HR size="1" noshade><FONT size="2">
  Edward M. Fitzgerald</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Senior Vice President,<BR>
  Chief Financial Officer and Treasurer<BR>
  (principal financial and accounting officer)
  </FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">June 14, 2002</FONT></TD>
  </TR>
  <TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">/s/ Jay R. LaMarche<BR>
  </FONT><HR size="1" noshade><FONT size="2">
  Jay R. LaMarche</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">June 14, 2002</FONT></TD>
  </TR>
  <TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">/s/ Sandford D. Smith<BR>
  </FONT><HR size="1" noshade><FONT size="2">
  Sandford D. Smith</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">June 14, 2002</FONT></TD>
  </TR>
  <TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">/s/ Vaughn D. Bryson<BR>
  </FONT><HR size="1" noshade><FONT size="2">
  Vaughn D. Bryson</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">June 14, 2002</FONT></TD>
  </TR>
  <TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">/s/ Raymond S. Troubh<BR>
  </FONT><HR size="1" noshade><FONT size="2">
  Raymond S. Troubh</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">June 14, 2002</FONT></TD>
  </TR>
  <TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">/s/ John M. Deutch<BR>
  </FONT><HR size="1" noshade><FONT size="2">
  John M. Deutch, Ph.D.</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">June 14, 2002</FONT></TD>
  </TR>
  <TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">/s/ Ralph Snyderman<BR>
  </FONT><HR size="1" noshade><FONT size="2">
  Ralph Snyderman, M.D.</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">June 14, 2002</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">II-5</FONT>
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <P align="center"><FONT size="2"><B>ARIAD PHARMACEUTICALS, INC.</B>
  </FONT>
  
  <P align="center"><FONT size="2"><B>INDEX TO EXHIBITS FILED WITH<BR>
  FORM S-8 REGISTRATION STATEMENT</B>
  </FONT>
  
  <!-- link1 "EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="010"></A></DIV>
  <P align="center"><FONT size="2"><B>EXHIBIT INDEX</B>
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="90%">
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="left"><FONT size="1"><B>Exhibit</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="left"><FONT size="1"><B>Number</B></FONT></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center"><FONT size="1"><B>Description</B></FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD nowrap align="center"><HR size="1" noshade></TD>
          <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Form of Common Stock Certificate (filed as an exhibit to
  the Registrant&#146;s Registration Statement on Form&nbsp;10, file number
  000-21696, filed with the Securities and Exchange Commission on
  June&nbsp;25, 1993 and incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.2</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Certificate of Incorporation, as amended (filed as Exhibit
  3.1 to the Registrant&#146;s Registration Statement on Form&nbsp;10, file
  number 000-21696, filed with the Securities and Exchange Commission
  on June&nbsp;25, 1993 and incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.3</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Amendment of Certificate of Incorporation dated April&nbsp;8,
  1994 (filed as Exhibit&nbsp;3.3 to the Registrant&#146;s Annual Report on
  Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 1993 filed with
  the Securities and Exchange Commission on April&nbsp;15, 1994 and
  incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.4</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Amendment of Certificate of Incorporation dated October&nbsp;4,
  1994 (filed as Exhibit&nbsp;3.4 to the Registrant&#146;s Annual Report on
  Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 1994 filed with
  the Securities and Exchange Commission on March&nbsp;30, 1995 and
  incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.5</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Restated By-laws, as amended (filed as Exhibit&nbsp;4.2 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-3, file number
  333-38664, filed with the Securities and Exchange Commission on
  June&nbsp;23, 2000 and incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">4.6</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Rights Agreement, dated as of June&nbsp;8, 2000, between the
  Registrant and State Street Bank and Trust Company, which includes
  the Form of Certificate of Designations in respect of the Series&nbsp;A
  Preferred Stock, as Exhibit&nbsp;A, the Form of Right Certificate as
  Exhibit&nbsp;B and the Summary of Rights to Purchase Series&nbsp;A Preferred
  Stock as Exhibit&nbsp;C (filed as Exhibit&nbsp;1 to the Registrant&#146;s
  Registration Statement on Form&nbsp;8-A, file number 000-21696, filed
  with the Securities and Exchange Commission on June&nbsp;19, 2000 and
  incorporated herein by reference).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">5.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C., as to the legality of the shares being registered.</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">23.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Consent of Deloitte &#038; Touche LLP</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">23.2</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  (filed with Exhibit&nbsp;5.1)</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">24.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  Power of Attorney (included on signature page).</FONT></TD>
  </TR>
  <TR valign="bottom">
          <TD width="8%">&nbsp;</TD>
          <TD width="5%">&nbsp;</TD>
          <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
          <TD valign="top"><FONT size="2">99.1</FONT></TD>
          <TD><FONT size="2">&nbsp;</FONT></TD>
          <TD align="left" valign="top"><FONT size="2">
  ARIAD Pharmaceuticals, Inc. 2001 Stock Plan, as amended.</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">II-6</FONT>
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on June 14, 2002
  REGISTRATION NO. 333-
  SECURITIES AND EXCHANGE
  COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  under the
  SECURITIES ACT OF 1933
  ARIAD PHARMACEUTICALS, INC.
  (Exact name of Registrant as specified in its
  charter)
  Delaware
  (
  State or other jurisdiction
  of incorporation or organization
  )
  22-3106987
  (
  I.R.S. Employer
  Identification No.
  )
  26 Landsdowne Street
  Cambridge, Massachusetts 02139
  (617) 494-0400
  (Address of Principal Executive Offices)
  THE ARIAD PHARMACEUTICALS, INC.
  2001 STOCK PLAN, AS AMENDED
  Harvey J. Berger, M.D.
  President and Chief Executive Officer
  ARIAD Pharmaceuticals, Inc.
  26 Landsdowne Street
  Cambridge, Massachusetts 02139-4234
  (617) 494-0400
  (Name, address, including zip code, and telephone number, including area
  code, of agent for service)
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  maximum
  maximum
  Title of
  Amount to be
  offering price
  aggregate
  Amount of
  securities to be registered
  registered(1)
  per share(2)
  offering price(2)
  registration fee
  Common Stock, $.001 par value
  1,600,000
  $
  3.88
  $
  6,208,000
  $
  571.14
  (1)
  The number of shares of common stock, par value $.001 per share ("Common
  Stock"), stated above consists of the aggregate number of additional
  shares not previously registered which may be sold upon the exercise of
  options which may hereafter be granted under The ARIAD Pharmaceuticals,
  Inc. 2001 Stock Plan, as amended (the "Plan"). The maximum number of
  shares which may be sold upon the exercise of such options granted under
  the Plan is subject to adjustment in accordance with certain anti-dilution
  and other provisions of the Plan. Accordingly, pursuant to Rule 416 under
  the Securities Act of 1933, as amended (the "Securities Act"), this
  Registration Statement covers, in addition to the number of shares stated
  above, an indeterminate number of shares which may be subject to grant or
  otherwise issuable after the operation of any such anti-dilution and other
  provisions.
  (2)
  This calculation is made solely for the purpose of determining the
  registration fee pursuant to the provisions of Rule 457(h) under the
  Securities Act based on the average of the high and low sale prices per
  share of the Common Stock on the National Market System of the National
  Association of Securities Dealers Automated Quotation System ("Nasdaq") as
  of a date (June 10, 2002) within 5 business days prior to filing this
  Registration Statement. None of the shares being registered hereunder are
  subject to outstanding options.
  TABLE OF CONTENTS
  EXPLANATORY NOTE
  PART II
  Item 3. Incorporation of Certain Documents by Reference.
  Item 4. Description of Securities.
  Item 5. Interests of Named Experts and Counsel.
  Item 6. Indemnification of Directors and Officers.
  Item 7. Exemption from Registration Claimed.
  Item 8. Exhibits.
  Item 9. Undertakings.
  SIGNATURES
  EXHIBIT INDEX
  Ex-5.1 Opinion and Consent of Mintz, Levin, Cohn..
  Ex-23.1 Consent of Deloitte & Touche  LLP
  Ex-99.1 2001 Stock Plan, amended
  Table of Contents
  EXPLANATORY NOTE
  In accordance with the instructional Note to Part I of Form S-8 as
  promulgated by the Securities and Exchange Commission, the information
  specified by Part I of Form S-8 has been omitted from this Registration
  Statement on Form S-8 for offers of Common Stock pursuant to the Plan. This
  Registration Statement on Form S-8 hereby registers 1,600,000 additional shares
  of Common Stock for issuance under the Plan. A Registration Statement on Form
  S-8 (File No. 333-63706), registering an aggregate of 1,330,000 shares of
  Common Stock under the Plan, was filed with the Commission on June 22, 2001.
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference.
  The following documents filed by the Registrant with the Commission are
  incorporated herein by reference:
  (a)
  The Registrant's Annual Report on Form 10-K for the fiscal year
  ended December 31, 2001;
  (b)
  The Registrant's Quarterly Report on Form 10-Q for the fiscal
  quarter ended March 31, 2002;
  (c)
  The Registrant's Definitive Proxy Statement filed on April 24,
  2002;
  (d)
  The Registrant's Current Report on Form 8-K filed on April 9,
  2002;
  (e)
  The description of the Common Stock contained in the
  Registrant's Registration Statement on Form 10 (File No. 0-21696)
  filed under the Securities Exchange Act of 1934 on June 25, 1993,
  including any amendment or report filed for the purpose of updating
  such description; and
  (f)
  The description of the Preferred Shares Purchase Rights
  contained in the Registrant's Registration Statement on Form 8-A
  (File No. 0-21696) filed under the Securities and Exchange Act of
  1934 on June 19, 2000, including any amendment or report filed for
  the purpose of updating such description.
  All reports and other documents filed by the Registrant after the date
  hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities
  Exchange Act of 1934 prior to the filing of a post-effective amendment which
  indicates that all securities offered hereby have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be
  incorporated by reference herein and to be part hereof from the date of filing
  of such reports and documents.
  Item 4. Description of Securities.
  Not applicable.
  Item 5. Interests of Named Experts and Counsel.
  The validity of the issuance of the shares of Common Stock registered
  under this Registration Statement has been passed upon for the Registrant by
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. of Boston, Massachusetts.
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm
  own an aggregate of approximately 11,500 shares of Common Stock of the
  Registrant.
  Item 6. Indemnification of Directors and Officers.
  Section 145(a) of the General Corporation Law of the State of Delaware
  provides that a Delaware corporation may indemnify any person who was or is a
  party or is threatened to be made a party to any threatened, pending or
  completed action, suit or proceeding, whether civil, criminal, administrative
  or investigative (other than an action by or in the right of the corporation)
  by reason of the fact that he is or was a director, officer, employee or agent
  of the corporation or is or was serving at the request of the corporation as a
  director, officer, employee or agent of another corporation or enterprise,
  against expenses, judgments, fines and amounts paid in settlement actually and
  reasonably incurred by him in connection with such action, suit or proceeding
  if he acted in good faith and in a manner he reasonably believed to be in or
  not opposed to the best interests of the corporation, and, with respect to any
  criminal action or proceeding, had no cause to believe his conduct was
  unlawful.
  Table of Contents
  Section 145(b) provides that a Delaware corporation may indemnify any
  person who was or is a party or is threatened to be made a party to any
  threatened, pending or completed action or suit by or in the right of the
  corporation to procure a judgment in its favor by reason of the fact that such
  person acted in any of the capacities set forth above, against expenses
  actually and reasonably incurred by him in connection with the defense or
  settlement of such action or suit if he acted under similar standards, except
  that no indemnification may be made in respect of any claim, issue or matter as
  to which such person shall have been adjudged to be liable to the corporation
  unless and only to the extent that the court in which such action or suit was
  brought shall determine that despite the adjudication of liability, such person
  is fairly and reasonably entitled to be indemnified for such expenses which the
  court shall
  deem proper.
  Section 145 further provides that to the extent a director or officer of a
  corporation has been successful in the defense of any action, suit or
  proceeding referred to in subsections (a) and (b) or in the defense of any
  claim, issue or matter therein, he shall be indemnified against expenses
  actually and reasonably incurred by him in connection therewith; that
  indemnification provided for by Section 145 shall not be deemed exclusive of
  any other rights to which the indemnified party may be entitled; and that the
  corporation may purchase and maintain insurance on behalf of a director or
  officer of the corporation against any liability asserted against him or
  incurred by him in any such capacity or arising out of his status as such
  whether or not the corporation would have the power to indemnify him against
  such liabilities under such Section 145.
  The Certificate of Incorporation, as amended, and By-laws of the
  Registrant provide for indemnification of the Registrant's directors and
  officers to the fullest extent permitted by law. The By-laws also permit the
  Board of Directors to authorize the Registrant to purchase and maintain
  insurance against any liability asserted against any director, officer,
  employee or agent of the Registrant arising out of his capacity as such.
  Insofar as indemnification for liabilities under the Securities Act may be
  permitted to directors, officers, or controlling persons of the Registrant
  pursuant to the Registrant's Certificate of Incorporation, as amended, its
  By-laws and the Delaware General Corporation Law, the Registrant has been
  informed that in the opinion of the Commission such indemnification is against
  public policy as expressed in such Act and is therefore unenforceable.
  As permitted by the Delaware General Corporation Law, the Registrant's
  Certificate of Incorporation, as amended, provides that directors of the
  Registrant shall not be personally liable to the Registrant or its stockholders
  for monetary damages for breach of fiduciary duty as a director, except for
  liability (i) for any breach of the director's duty of loyalty to the
  Registrant or its stockholders, (ii) for acts or omissions not in good faith or
  which involve intentional misconduct or a knowing violation of law, (iii) under
  Section 174 of the Delaware General Corporation Law, relating to prohibited
  dividends or distributions or the repurchase or redemption of stock or (iv) for
  any transaction from which the director derives an improper personal benefit.
  As a result of this provision, the Registrant and its stockholders may be
  unable to obtain monetary damages from a director for breach of his or her duty
  of care.
  Item 7. Exemption from Registration Claimed.
  Not applicable.
  II-2
  Table of Contents
  Item 8. Exhibits.
  Exhibit
  Number
  Description
  4.1
  Form of Common Stock Certificate (filed as an exhibit to
  the Registrant's Registration Statement on Form 10, file number
  000-21696, filed with the Securities and Exchange Commission on
  June 25, 1993 and incorporated herein by reference).
  4.2
  Certificate of Incorporation, as amended (filed as Exhibit
  3.1 to the Registrant's Registration Statement on Form 10, file
  number 000-21696, filed with the Securities and Exchange Commission
  on June 25, 1993 and incorporated herein by reference).
  4.3
  Amendment of Certificate of Incorporation dated April 8,
  1994 (filed as Exhibit 3.3 to the Registrant's Annual Report on
  Form 10-K for the fiscal year ended December 31, 1993 filed with
  the Securities and Exchange Commission on April 15, 1994 and
  incorporated herein by reference).
  4.4
  Amendment of Certificate of Incorporation dated October 4,
  1994 (filed as Exhibit 3.4 to the Registrant's Annual Report on
  Form 10-K for the fiscal year ended December 31, 1994 filed with
  the Securities and Exchange Commission on March 30, 1995 and
  incorporated herein by reference).
  4.5
  Restated By-laws, as amended (filed as Exhibit 4.2 to the
  Registrant's Registration Statement on Form S-3, file number
  333-38664, filed with the Securities and Exchange Commission on
  June 23, 2000 and incorporated herein by reference).
  4.6
  Rights Agreement, dated as of June 8, 2000, between the
  Registrant and State Street Bank and Trust Company, which includes
  the Form of Certificate of Designations in respect of the Series A
  Preferred Stock, as Exhibit A, the Form of Right Certificate as
  Exhibit B and the Summary of Rights to Purchase Series A Preferred
  Stock as Exhibit C (filed as Exhibit 1 to the Registrant's
  Registration Statement on Form 8-A, file number 000-21696, filed
  with the Securities and Exchange Commission on June 19, 2000 and
  incorporated herein by reference).
  5.1
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C., as to the legality of the shares being registered.
  23.1
  Consent of Deloitte & Touche LLP
  23.2
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  (filed with Exhibit 5.1)
  24.1
  Power of Attorney (included on signature page).
  99.1
  ARIAD Pharmaceuticals, Inc. 2001 Stock Plan, as amended.
  Item 9. Undertakings.
  (a)
  The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made, a
  post-effective amendment to this Registration Statement:
  (i) To include any prospectus required by Section 10(a)(3) of
  the Securities Act of 1933;
  (ii) To reflect in the prospectus any facts or events arising
  after the effective date of the Registration Statement (or the most
  recent post-effective amendment thereof) which, individually or in the
  II-3
  Table of Contents
  aggregate, represents a fundamental change in the information
  set forth in the Registration Statement. Notwithstanding the
  foregoing, any increase or decrease in volume of securities offered
  (if the total dollar value of securities offered would not exceed
  that which was registered) and any deviation from the low or high
  end of the estimated maximum offering range may be reflected in the
  form of prospectus filed with the Commission pursuant to Rule 424(b)
  (Section 230.424(b) of this chapter) if, in the aggregate, the
  changes in volume and price represent no more than a 20% change in
  the maximum aggregate offering price set forth in the "Calculation
  of Registration Fee" table in the effective Registration Statement;
  (iii) To include any material information with respect to the
  plan of distribution not previously disclosed in the Registration
  Statement or any material change to such information in the
  Registration Statement;
  Provided, however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not
  apply if the information required to be included in a post-effective
  amendment by those paragraphs is contained in periodic reports filed by
  the Registrant pursuant to Section 13 or Section 15(d) of the Securities
  Exchange Act of 1934 that are incorporated by reference in this
  Registration Statement.
  (2) That, for the purpose of determining any liability under the
  Securities Act of 1933, each such post-effective amendment shall be deemed
  to be a new registration statement relating to the securities offered
  therein, and the offering of such securities at that time shall be deemed
  to be the initial bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment any
  of the securities being registered which remain unsold at the termination
  of the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act of 1933, each filing of
  the Registrant's annual report pursuant to Section 13(a) or Section 15(d)
  of the Securities Exchange Act of 1934 that is incorporated by reference
  in this Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered therein, and the offering of
  such securities at that time shall be deemed to be the initial bona fide
  offering thereof.
  (c)
  Insofar as indemnification for liabilities arising under the Securities
  Act of 1933 may be permitted to directors, officers and controlling
  persons of the Registrant pursuant to the foregoing provisions, or
  otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public
  policy as expressed in the Act and is, therefore, unenforceable. In the
  event that a claim for indemnification against such liabilities (other
  than the payment by the Registrant of expenses incurred or paid by a
  director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted by such
  director, officer or controlling person in connection with the securities
  being registered, the Registrant will, unless in the opinion of its
  counsel the matter has been settled by controlling precedent, submit to a
  court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Act and
  will be governed by the final adjudication of such issue.
  II-4
  Table of Contents
  SIGNATURES
  The Registrant.
  Pursuant to the requirements of the Securities Act of
  1933, the Registrant certifies that it has reasonable grounds to believe that
  it meets all of the requirements for filing on Form S-8 and has duly caused
  this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Cambridge, Massachusetts on June 14, 2002.
  ARIAD PHARMACEUTICALS, INC.
  By: /s/ Harvey J. Berger
  ————————————————————
  Harvey J. Berger, M.D.
  President and Chief Executive Officer
  Each person whose signature appears below constitutes and appoints Harvey
  J. Berger and Edward M. Fitzgerald, and each of them, his true and lawful
  attorneys-in-fact and agents, with full power of substitution and
  resubstitution in each of them, for him and in his name, place and stead, and
  in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement on Form S-8 of ARIAD
  Pharmaceuticals, Inc., or any other registration statement for the same
  offering that is to be effective upon filing pursuant to Rule 462(b) under the
  Securities Act of 1933, as amended, and to file the same, with all exhibits
  thereto and other documents in connection therewith, with the Securities and
  Exchange Commission, granting unto said attorneys-in-fact and agents, and each
  of them, full power and authority to do and perform each and every act and
  thing requisite or necessary to be done in or about the premises, as full to
  all intents and purposes as he might or could do in person, hereby ratifying
  and confirming all that said attorneys-in-fact and agents or any of them or
  their or his substitute or substitutes may lawfully do or cause to be done by
  virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed by the following persons in the
  capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Harvey J. Berger
  Harvey J. Berger, M.D.
  Chairman of the Board,
  President and Chief Executive Officer
  (principal executive officer)
  June 14, 2002
  /s/ Edward M. Fitzgerald
  Edward M. Fitzgerald
  Senior Vice President,
  Chief Financial Officer and Treasurer
  (principal financial and accounting officer)
  June 14, 2002
  /s/ Jay R. LaMarche
  Jay R. LaMarche
  Director
  June 14, 2002
  /s/ Sandford D. Smith
  Sandford D. Smith
  Director
  June 14, 2002
  /s/ Vaughn D. Bryson
  Vaughn D. Bryson
  Director
  June 14, 2002
  /s/ Raymond S. Troubh
  Raymond S. Troubh
  Director
  June 14, 2002
  /s/ John M. Deutch
  John M. Deutch, Ph.D.
  Director
  June 14, 2002
  /s/ Ralph Snyderman
  Ralph Snyderman, M.D.
  Director
  June 14, 2002
  II-5
  Table of Contents
  ARIAD PHARMACEUTICALS, INC.
  INDEX TO EXHIBITS FILED WITH
  FORM S-8 REGISTRATION STATEMENT
  EXHIBIT INDEX
  Exhibit
  Number
  Description
  4.1
  Form of Common Stock Certificate (filed as an exhibit to
  the Registrant's Registration Statement on Form 10, file number
  000-21696, filed with the Securities and Exchange Commission on
  June 25, 1993 and incorporated herein by reference).
  4.2
  Certificate of Incorporation, as amended (filed as Exhibit
  3.1 to the Registrant's Registration Statement on Form 10, file
  number 000-21696, filed with the Securities and Exchange Commission
  on June 25, 1993 and incorporated herein by reference).
  4.3
  Amendment of Certificate of Incorporation dated April 8,
  1994 (filed as Exhibit 3.3 to the Registrant's Annual Report on
  Form 10-K for the fiscal year ended December 31, 1993 filed with
  the Securities and Exchange Commission on April 15, 1994 and
  incorporated herein by reference).
  4.4
  Amendment of Certificate of Incorporation dated October 4,
  1994 (filed as Exhibit 3.4 to the Registrant's Annual Report on
  Form 10-K for the fiscal year ended December 31, 1994 filed with
  the Securities and Exchange Commission on March 30, 1995 and
  incorporated herein by reference).
  4.5
  Restated By-laws, as amended (filed as Exhibit 4.2 to the
  Registrant's Registration Statement on Form S-3, file number
  333-38664, filed with the Securities and Exchange Commission on
  June 23, 2000 and incorporated herein by reference).
  4.6
  Rights Agreement, dated as of June 8, 2000, between the
  Registrant and State Street Bank and Trust Company, which includes
  the Form of Certificate of Designations in respect of the Series A
  Preferred Stock, as Exhibit A, the Form of Right Certificate as
  Exhibit B and the Summary of Rights to Purchase Series A Preferred
  Stock as Exhibit C (filed as Exhibit 1 to the Registrant's
  Registration Statement on Form 8-A, file number 000-21696, filed
  with the Securities and Exchange Commission on June 19, 2000 and
  incorporated herein by reference).
  5.1
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C., as to the legality of the shares being registered.
  23.1
  Consent of Deloitte & Touche LLP
  23.2
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  (filed with Exhibit 5.1)
  24.1
  Power of Attorney (included on signature page).
  99.1
  ARIAD Pharmaceuticals, Inc. 2001 Stock Plan, as amended.
  II-6