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  <TITLE>Alkermes, Inc.</TITLE>
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  <P align="right"><FONT size="2">Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  </FONT>
  
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  <P align="center"><FONT size="4"><B>SECURITIES AND EXCHANGE COMMISSION
  </B></FONT>
  
  
  <DIV align="center"><FONT size="3"><B>Washington, D.C. 20549</B>
  </FONT></DIV>
  
  
  <P align="center"><FONT size="5"><B>____________________
  </B></FONT>
  
  
  <P align="center"><FONT size="5"><B>FORM S-8<BR>
  REGISTRATION STATEMENT
  </B></FONT>
  
  
  <P align="center"><FONT size="3"><B>UNDER THE SECURITIES ACT OF 1933</B>
  </FONT>
  
  
  <P align="center"><FONT size="3"><B>___________________</B>
  </FONT>
  
  
  <P align="center"><FONT size="6"><B>ALKERMES, INC.
  </B></FONT>
  
  
  <DIV align="center"><FONT size="2">(Exact name of registrant as specified in its charter)
  </FONT></DIV>
  
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      <TD align="center" valign="top"><FONT size="2">Pennsylvania</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center" valign="top"><FONT size="2">
  23-2472830</FONT></TD>
  </TR>
  
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      <TD align="center" valign="top"><FONT size="2">(State or other jurisdiction of<BR>
  incorporation or organization)</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center" valign="top"><FONT size="2">
  (I.R.S. Employer<BR>
  Identification Number)</FONT></TD>
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  <P align="center"><FONT size="2"><B>ALKERMES, INC.<BR>
  88 SIDNEY STREET<BR>
  CAMBRIDGE, MASSACHUSETTS 02139-4234<BR>
  TELEPHONE: (617)&nbsp;494-0171</B><BR>
  (Address, including zip code, and telephone number, including area code,<BR>
  of registrant&#146;s principal executive offices)
  </FONT>
  
  
  <P align="center"><FONT size="2"><B>ALKERMES, INC. 2002 RESTRICTED STOCK AWARD PLAN</B><BR>
  (Full title of the plan)
  </FONT>
  
  
  <P align="center"><FONT size="2">Richard F. Pops<BR>
  Chief Executive Officer<BR>
  ALKERMES, INC.<BR>
  88 Sidney Street<BR>
  Cambridge, Massachusetts 02139-4234<BR>
  Telephone: (617)&nbsp;494-0171<BR>
  (Name, address, including zip code, and telephone number, including area code,<BR>
  of agent for service)
  </FONT>
  
  
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  <P align="center"><FONT size="2">Copies to:<BR>
  Jennifer L. Miller, Esquire<BR>
  Ballard Spahr Andrews &#038; Ingersoll, LLP<BR>
  1735 Market Street, 51st Floor<BR>
  Philadelphia, Pennsylvania 19103<BR>
  Telephone: (215)&nbsp;864-8619
  </FONT>
  
  
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  <P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B>
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      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD nowrap align="center"><FONT size="1"><B>Title of Securities</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount to be</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price Per</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate Offering</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>to be Registered</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered(1)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Share(2)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price(2)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration Fee</B></FONT></TD>
  </TR>
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      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock,
  Par value $.01 per
  share</FONT></DIV></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">500,000</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">12.58</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">6,290,000</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">508.86</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416(a) under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend and the like.</FONT></TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="96%"><FONT size="2">Estimated solely for the purpose of calculating the registration fee. In
  accordance with Rule&nbsp;457(h), the price shown is based upon the average of
  the high and low price of the Company&#146;s Common Stock on July&nbsp;16, 2003,
  $12.58, as reported on the Nasdaq National Market for securities of the
  same class as those to be offered.</FONT></TD>
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  </TABLE>
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  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
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  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART II &#151; INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Certain Documents by Reference.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;4. Description of Securities.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Officers and Directors.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;7. Exemption from Registration Claimed.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;8. Exhibits.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;9. Undertakings</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#008">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#009">EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47243aiexv5.txt">Ex-5 Opinion of Ballard Spahr Andrews & Ingersoll</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47243aiexv23w2.txt">Ex-23.2 Consent of Deloitte & Touche LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b47243aiexv23w3.txt">Ex-23.3 Consent of Ernst & Young LLP</A></TD></TR>
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  <!-- link1 "PART II &#151; INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="center"><FONT size="2">PART II &#151; INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  </FONT>
  
  <!-- link2 "Item&nbsp;3. Incorporation of Certain Documents by Reference." -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;3. Incorporation of Certain Documents by Reference.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed with the Securities and Exchange Commission
  (the &#147;Commission&#148;) pursuant to the Securities Exchange Act of 1934 (the
  &#147;Exchange Act&#148;) by Alkermes, Inc. (the &#147;Company&#148;) (File No.&nbsp;1-14131) or
  pursuant to the Securities Act of 1933, as amended (the &#147;Securities Act&#148;) are
  incorporated herein by reference:
  </FONT>
  
  
  <P>
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  <TR valign="top">
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(a)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%"><FONT size="2">Annual Report on Form&nbsp;10-K for the fiscal year
  ended March&nbsp;31, 2003;</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(b)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%"><FONT size="2">Item&nbsp;1 of Registration Statement of the Company
  on Form&nbsp;8-A dated June&nbsp;28, 1991, as amended by a Registration Statement of the Company on
  Form&nbsp;8-A/A dated January&nbsp;17, 1997; and</FONT></TD>
  </TR>
  <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR valign="top">
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="1%" align="left" nowrap><FONT size="2">(c)</FONT></TD>
      <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="93%"><FONT size="2">Item&nbsp;1 of Registration Statement of the Company
  on Form&nbsp;8-A dated May&nbsp;2, 2003.</FONT></TD>
  </TR>
  </TABLE>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14
  or 15(d) of the Exchange Act, after the date of this Registration Statement and
  prior to the termination of the offering, shall be deemed to be incorporated by
  reference herein and to be part hereof from the date of filing such documents.
  Any statement contained herein or in a document incorporated by reference or
  deemed to be incorporated by reference herein shall be deemed to be modified or
  superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document
  which is incorporated or is deemed to be incorporated by reference herein. Any
  such statement so modified or superseded shall not be deemed, except as so
  modified or superseded, to constitute a part of this Registration Statement.
  </FONT>
  
  <!-- link2 "Item&nbsp;4. Description of Securities." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;4. Description of Securities.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </FONT>
  
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Morris Cheston, Jr., Esquire, Secretary of the Company and Jennifer L.
  Miller, Esquire, Secretary of Alkermes Investments, Inc., a wholly-owned
  subsidiary of Alkermes, Inc., are both partners in the law firm of Ballard
  Spahr Andrews &#038; Ingersoll, LLP which has given an opinion passing upon the
  validity of the securities being registered hereby.
  </FONT>
  
  <!-- link2 "Item&nbsp;6. Indemnification of Officers and Directors." -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;6. Indemnification of Officers and Directors.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Pennsylvania Business Corporation Law of 1988, as amended, authorizes
  the Company to grant indemnification to directors and officers in terms
  sufficiently broad to permit such indemnification under certain circumstances
  for liabilities (including reimbursement for expenses incurred) arising under
  the Securities Act of 1933, as amended. In addition, the Company has also
  obtained Directors&#146; and Officers&#146; Liability Insurance in the amount of
  $20,000,000 which insures its officers and directors against certain
  liabilities such persons may incur in their capacities as officers or directors
  of the Company.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Article&nbsp;5 of the Company&#146;s By-Laws provides as follows:
  <P align="center"><FONT size="2">II-1</FONT>
  
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  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.1 INDEMNIFICATION OF DIRECTORS, OFFICERS, AND OTHER PERSONS. The
  Corporation shall indemnify any director, officer, employee or agent of the
  Corporation or any of its subsidiaries who was or is an &#147;authorized
  representative&#148; of the Corporation (which shall mean, for the purpose of this
  Article, a director or officer of the Corporation, or a person serving at the
  request of the Corporation as a director, officer, partner, fiduciary or
  trustee of another corporation, partnership, joint venture, trust, employee
  benefit plan or other enterprise) and who was or is a &#147;party&#148; (which shall
  include for purposes of this Article the giving of testimony or similar
  involvement) or is threatened to be made a party to any &#147;proceeding&#148; (which
  shall mean for purposes of this Article any threatened, pending or completed
  action, suit, appeal or other proceeding of any nature, whether civil,
  criminal, administrative or investigative, whether formal or informal, and
  whether brought by or in the right of the Corporation, its shareholders or
  otherwise) by reason of the fact that such person was or is an authorized
  representative of the Corporation to the fullest extent permitted by law,
  including without limitation indemnification against expenses (which shall
  include for purposes of this Article attorneys&#146; fees and disbursements),
  damages, punitive damages, judgments, penalties, fines and amounts paid in
  settlement actually and reasonably incurred by such person in connection with
  such proceeding unless the act or failure to act giving rise to the claim is
  finally determined by a court to have constituted willful misconduct or
  recklessness. If an authorized representative is not entitled to
  indemnification in respect of a portion of any liabilities to which such person
  may be subject, the Corporation shall nonetheless indemnify such person to the
  maximum extent for the remaining portion of the liabilities.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.2 ADVANCEMENT OF EXPENSES. The Corporation shall pay the expenses
  (including attorneys&#146; fees and disbursements) actually and reasonably incurred
  in defending a proceeding on behalf of any person entitled to indemnification
  under Section&nbsp;5.1 in advance of the final disposition of such proceeding upon
  receipt of an undertaking by or on behalf of such person to repay such amount
  if it shall ultimately be determined that such person is not entitled to be
  indemnified by the Corporation as authorized in this Article and may pay such
  expenses in advance on behalf of any employee or agent on receipt of a similar
  undertaking. The financial ability of such authorized representative to make
  such repayment shall not be prerequisite to the making of an advance.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.3 EMPLOYEE BENEFIT PLANS. For purposes of this Article, the Corporation
  shall be deemed to have requested an officer, director, employee or agent to
  serve as fiduciary with respect to an employee benefit plan where the
  performance by such person of duties to the Corporation also imposes duties on,
  or otherwise involves services by, such person as a fiduciary with respect to
  the plan; excise taxes assessed on an authorized representative with respect to
  any transaction with an employee benefit plan shall be deemed &#147;fines&#148;; and
  action taken or omitted by such person with respect to an employee benefit plan
  in the performance of duties for a purpose reasonably believed to be in the
  interest of the participants and beneficiaries of the plan shall be deemed to
  be for a purpose which is not opposed to the best interests of the Corporation.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.4 SECURITY FOR INDEMNIFICATION OBLIGATIONS. To further effect, satisfy
  or secure the indemnification obligations provided herein or otherwise, the
  Corporation may maintain insurance, obtain a letter of credit, act as
  self-insurer, create a reserve, trust, escrow, cash collateral or other fund or
  account, enter into indemnification agreements, pledge or grant a security
  interest in any assets or properties of the Corporation, or use any other
  mechanism or arrangement whatsoever in such amounts, at such costs, and upon
  such other terms and conditions as the Board of Directors shall deem
  appropriate.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.5 RELIANCE UPON PROVISIONS. Each person who shall act as an authorized
  representative of the Corporation shall be deemed to be doing so in reliance
  upon the rights of indemnification provided by this Article.
  </FONT>
  
  <P align="center"><FONT size="2">II-2</FONT>
  
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  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.6 AMENDMENT OR REPEAL. All rights of indemnification under this Article
  shall be deemed a contract between the Corporation and the person entitled to
  indemnification under this Article pursuant to which the Corporation and each
  such person intend to be legally bound. Any repeal, amendment or modification
  hereof shall be prospective only and shall not limit, but may expand, any
  rights or obligations in respect of any proceeding whether commenced prior to
  or after such change to the extent such proceeding pertains to actions or
  failures to act occurring prior to such change.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.7 SCOPE OF ARTICLE. The indemnification, as authorized by this Article,
  shall not be deemed exclusive of any other rights to which those seeking
  indemnification or advancement of expenses may be entitled under any statute,
  agreement, vote of shareholders or disinterested directors or otherwise, both
  as to action in an official capacity and as to action in any other capacity
  while holding such office. The indemnification and advancement of expenses
  provided by, or granted pursuant to, this Article shall continue as to a person
  who has ceased to be an officer, director, employee or agent in respect of
  matters arising prior to such time, and shall inure to the benefit of the
  heirs, executors and administrators of such person.
  </FONT>
  
  <!-- link2 "Item&nbsp;7. Exemption from Registration Claimed." -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;7. Exemption from Registration Claimed.</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </FONT>
  
  <!-- link2 "Item&nbsp;8. Exhibits." -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits.</B>
  </FONT>
  
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  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1 as amended (File No.&nbsp;33-40250)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Non-Voting Common Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit&nbsp;4.4 to the Registrant&#146;s
  Report on Form&nbsp;10-K for the fiscal year ended March&nbsp;31, 1999).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of 2002 Preferred Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s
  Current Report on Form&nbsp;8-K filed on December&nbsp;13, 2002).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.4</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Indenture, dated as of February&nbsp;18, 2000, between Alkermes,
  Inc. and State Street Bank and Trust Company, as Trustee (3.75%
  Subordinated Notes). (Incorporated by reference to Exhibit&nbsp;4.6 to
  the Registrant&#146;s Registration Statement on Form&nbsp;S-3, as amended
  (File No.&nbsp;333-31354)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Form of Indenture between Alkermes, Inc. and State Street
  Bank and Trust Company, as Trustee (6.52% Senior Notes).
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.
  333-101464)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.6</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Rights Agreement, dated February&nbsp;7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Registration Statement
  on Form&nbsp;8-A filed on May&nbsp;2, 2003).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Opinion of Ballard Spahr Andrews &#038; Ingersoll, LLP as to the
  legality of the securities to be offered.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Ballard Spahr Andrews &#038; Ingersoll, LLP (included as part of Exhibit&nbsp;5).</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">II-3</FONT>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Independent Auditors&#146; Consent of Deloitte &#038; Touche LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Independent Auditors of Ernst &#038; Young LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">24</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Power of Attorney (included in signature page).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">99</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Alkermes, Inc. 2002 Restricted Stock Award Plan (Incorporated
  by reference to Exhibit&nbsp;10.2 to the Registrant&#146;s Quarterly Report on
  Form&nbsp;10-Q for the quarter ended September&nbsp;30, 2002).</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <!-- link2 "Item&nbsp;9. Undertakings" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <P align="left"><FONT size="2"><B>Item&nbsp;9. Undertakings</B>
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The undersigned registrant hereby undertakes:
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp; To file, during any period in which offers or sales are being made, a
  post-effective amendment to this registration statement:
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp; To include any prospectus required by section 10(a)(3) of the
  Securities Act of 1933;
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp; To reflect in the prospectus any facts or events arising after the
  effective date of the registration statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a
  fundamental change in the information set forth in the registration statement.
  Notwithstanding the foregoing, any increase or decrease in volume of securities
  offered (if the total dollar value of securities offered would not exceed that
  which was registered) and any deviation from the low or high end of the
  estimated maximum offering range may be reflected in the form of prospectus
  filed with the Commission pursuant to Rule&nbsp;424(b) if, in the aggregate, the
  changes in volume and price represent no more than a 20% change in the maximum
  aggregate offering price set forth in the &#147;Calculation of Registration Fee&#148;
  table in the effective registration statement;
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp; To include any material information with respect to the plan of
  distribution not previously disclosed in the registration statement or any
  material change to such information in the registration statement;
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however, </I>that paragraphs (1)(i) and (1)(ii) do not apply
  if the registration statement is on Form&nbsp;S-3 or Form&nbsp;S-8, and the information
  required to be included in a post-effective amendment by those paragraphs is
  contained in periodic reports filed by the registrant pursuant to Section&nbsp;13 or
  Section&nbsp;15(d) of the Securities Exchange Act of 1934 that are incorporated by
  reference in the registration statement.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp; That, for the purpose of determining any liability under the
  Securities Act of 1933, each such post-effective amendment shall be deemed to
  be a new registration statement relating to the securities offered therein, and
  the offering of such securities at that time shall be deemed to be the initial
  bona fide offering thereof.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp; To remove from registration by means of a post-effective amendment any
  of the securities being registered which remain unsold at the termination of
  the offering.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Company hereby undertakes that, for purposes of determining any
  liability under the Securities Act of 1933, each filing of the Company&#146;s annual
  report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of the Securities Exchange
  Act of 1934 (and, where applicable, each filing of an employee benefit
  </FONT>
  
  <P align="center"><FONT size="2">II-4</FONT>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  <P align="left"><FONT size="2">plan&#146;s annual report pursuant to Section&nbsp;15(d) of the Securities Exchange
  Act of 1934) that is incorporated by reference in the registration statement
  shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be
  deemed to be the initial bona fide offering thereof.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar as indemnification for liabilities arising under the Securities
  Act of 1933 may be permitted to directors, officers and controlling persons of
  the registrant pursuant to the foregoing provisions, or otherwise, the
  registrant has been advised that in the opinion of the Securities and Exchange
  Commission such indemnification is against public policy as expressed in the
  Act and is, therefore, unenforceable. In the event that a claim for
  indemnification against such liabilities (other than the payment by the
  registrant of expenses incurred or paid by a director, officer or controlling
  person of the registrant in the successful defense of any action, suit or
  proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the registrant will, unless in
  the opinion of its counsel the matter has been settled by controlling
  precedent, submit to a court of appropriate jurisdiction the question whether
  such indemnification by it is against public policy as expressed in the Act and
  will be governed by the final adjudication of such issue.
  </FONT>
  
  <P align="center"><FONT size="2">II-5</FONT>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <P align="center"><FONT size="2">SIGNATURES
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form&nbsp;S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of Cambridge, Commonwealth of Massachusetts, on July
  21, 2003.
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="55%">
  <TR valign="bottom">
      <TD width="17%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD colspan="3" valign="top" align="left"><FONT size="2">ALKERMES, INC.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  By
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">/s/ Richard F. Pops</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Richard F. Pops</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">Chief Executive Officer</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed below by the following persons in the
  capacities and on the dates indicated.
  </FONT>
  
  <P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below in so signing also makes,
  constitutes and appoints Richard F. Pops and James M. Frates, and each of them,
  his true and lawful attorney-in-fact, with full power of substitution, for him
  in any and all capacities, to execute and cause to be filed with the Securities
  and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in
  connection therewith, and hereby ratifies and confirms all that said
  attorney-in-fact or his substitute or substitutes may do or cause to be done by
  virtue hereof.
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="85%">
  <TR valign="bottom">
      <TD width="35%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="24%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2"><BR>
  <HR size="1" noshade>
  Michael A. Wall</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director and
  Chairman of the
  Board
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"></FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Richard F. Pops
  <HR size="1" noshade>
  Richard F. Pops</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director and Chief
  Executive Officer
  (Principal
  Executive Officer)
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Robert A. Breyer
  <HR size="1" noshade>
  Robert A. Breyer</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ James M. Frates
  <HR size="1" noshade>
  James M. Frates</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Vice President, Chief
  Financial Officer and
  Treasurer
  (Principal Financial Officer
  and Principal Accounting
  Officer)
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">II-6</FONT>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="85%">
  <TR valign="bottom">
      <TD width="35%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="24%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Floyd E. Bloom
  <HR size="1" noshade>
  Floyd E. Bloom</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ John K. Clarke
  <HR size="1" noshade>
  John K. Clarke</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Alexander Rich
  <HR size="1" noshade>
  Alexander Rich</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Paul Schimmel
  <HR size="1" noshade>
  Paul Schimmel</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July&nbsp;21, 2003</FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  <TR>
      <TD valign="top"><FONT size="2">/s/ Gerri Henwood<BR>
  <HR size="1" noshade>
  Gerri Henwood</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July 21, 2003</FONT></TD>
  </TR>
  
  <TR valign="bottom">
  
      <TD valign="top"><FONT size="2"></FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR>
      <TD valign="top"><FONT size="2">/s/ Paul J. Mitchell<BR><HR size="1" noshade>
  Paul J. Mitchell</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Director
  </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">July 21, 2003</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  <P align="center"><FONT size="2">II-7</FONT>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <!-- link1 "EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="009"></A></DIV>
  
  <P align="center"><FONT size="2"><B>EXHIBIT INDEX</B>
  </FONT>
  
  <CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Number</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Exhibit</B></FONT></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by
  reference to Exhibit&nbsp;4 to the Registrant&#146;s Registration Statement on Form
  S-1 as amended (File No.&nbsp;33-40250)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of Non-Voting Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4.4 to the Registrant&#146;s Report on
  Form 10-K for the fiscal year ended March&nbsp;31, 1999).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Current
  Report on Form&nbsp;8-K filed on December&nbsp;13, 2002).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.4</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Indenture, dated as of February&nbsp;18, 2000, between Alkermes, Inc. and
  State Street Bank and Trust Company, as Trustee (3.75% Subordinated
  Notes). (Incorporated by reference to Exhibit&nbsp;4.6 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-3, as amended (File No.&nbsp;333-31354)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Form of Indenture between Alkermes, Inc. and State Street Bank and Trust
  Company, as Trustee (6.52% Senior Notes). (Incorporated by reference to
  Exhibit&nbsp;4.1 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as
  amended (File No.&nbsp;333-101464)).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">4.6</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Rights Agreement, dated February&nbsp;7, 2003, as amended, between Alkermes,
  Inc. and EquiServe Trust Co., N.A., as Rights Agent. (Incorporated by
  reference to Exhibit&nbsp;4.1 to the Registrant&#146;s Registration Statement on Form&nbsp;8-A filed on
  May&nbsp;2, 2003).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">5</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Opinion of Ballard Spahr Andrews &#038; Ingersoll, LLP as to the legality of
  the securities to be offered.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.1</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Ballard Spahr Andrews &#038; Ingersoll, LLP (included as part of Exhibit&nbsp;5).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.2</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Independent Auditors&#146; Consent of Deloitte &#038; Touche LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">23.3</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Consent of Independent Auditors of Ernst &#038; Young LLP.</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">24</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Power of Attorney (included in signature page).</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
  </TR>
  
  <TR valign="bottom">
      <TD valign="top"><FONT size="2">99</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">
  Alkermes, Inc. 2002 Restricted Stock Award Plan (Incorporated by
  reference to Exhibit&nbsp;10.2 to the Registrant&#146;s Quarterly Report on Form
  10-Q for the quarter ended September&nbsp;30, 2002).</FONT></TD>
  </TR>
  </TABLE>
  </CENTER>
  
  
  <P align="center"><FONT size="2">&nbsp;</FONT>
  
  
  
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metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "b47243aisv8.htm", "description": "ALKERMES, INC.", "secsgml_size_bytes": 54424}]
metadata_filer: {"company-data": {"conformed-name": "ALKERMES INC", "cik": "0000874663", "assigned-sic": "2834", "irs-number": "232472830", "state-of-incorporation": "PA", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-107208", "film-number": "03794934"}, "business-address": {"street1": "88 SIDNEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02139-4136", "phone": "617-494-0171"}}
text: Alkermes, Inc.
  Table of Contents
  Registration No. 333-
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  ____________________
  FORM S-8
  REGISTRATION STATEMENT
  UNDER THE SECURITIES ACT OF 1933
  ___________________
  ALKERMES, INC.
  (Exact name of registrant as specified in its charter)
  Pennsylvania
  23-2472830
  (State or other jurisdiction of
  incorporation or organization)
  (I.R.S. Employer
  Identification Number)
  ALKERMES, INC.
  88 SIDNEY STREET
  CAMBRIDGE, MASSACHUSETTS 02139-4234
  TELEPHONE: (617) 494-0171
  (Address, including zip code, and telephone number, including area code,
  of registrant's principal executive offices)
  ALKERMES, INC. 2002 RESTRICTED STOCK AWARD PLAN
  (Full title of the plan)
  Richard F. Pops
  Chief Executive Officer
  ALKERMES, INC.
  88 Sidney Street
  Cambridge, Massachusetts 02139-4234
  Telephone: (617) 494-0171
  (Name, address, including zip code, and telephone number, including area code,
  of agent for service)
  Copies to:
  Jennifer L. Miller, Esquire
  Ballard Spahr Andrews & Ingersoll, LLP
  1735 Market Street, 51st Floor
  Philadelphia, Pennsylvania 19103
  Telephone: (215) 864-8619
  CALCULATION OF REGISTRATION FEE
  Proposed Maximum
  Proposed Maximum
  Title of Securities
  Amount to be
  Offering Price Per
  Aggregate Offering
  Amount of
  to be Registered
  Registered(1)
  Share(2)
  Price(2)
  Registration Fee
  Common Stock,
  Par value $.01 per
  share
  500,000
  $
  12.58
  $
  6,290,000
  $
  508.86
  Table of Contents
  (1)
  Pursuant to Rule 416(a) under the Securities Act of 1933, this
  registration statement shall also be deemed to cover an indeterminate
  number of additional shares of Common Stock issuable in the event the
  number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend and the like.
  (2)
  Estimated solely for the purpose of calculating the registration fee. In
  accordance with Rule 457(h), the price shown is based upon the average of
  the high and low price of the Company's Common Stock on July 16, 2003,
  $12.58, as reported on the Nasdaq National Market for securities of the
  same class as those to be offered.
  TABLE OF CONTENTS
  PART II — INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference.
  Item 4. Description of Securities.
  Item 5. Interests of Named Experts and Counsel.
  Item 6. Indemnification of Officers and Directors.
  Item 7. Exemption from Registration Claimed.
  Item 8. Exhibits.
  Item 9. Undertakings
  SIGNATURES
  EXHIBIT INDEX
  Ex-5 Opinion of Ballard Spahr Andrews & Ingersoll
  Ex-23.2 Consent of Deloitte & Touche LLP
  Ex-23.3 Consent of Ernst & Young LLP
  Table of Contents
  PART II — INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Certain Documents by Reference.
  The following documents filed with the Securities and Exchange Commission
  (the "Commission") pursuant to the Securities Exchange Act of 1934 (the
  "Exchange Act") by Alkermes, Inc. (the "Company") (File No. 1-14131) or
  pursuant to the Securities Act of 1933, as amended (the "Securities Act") are
  incorporated herein by reference:
  (a)
  Annual Report on Form 10-K for the fiscal year
  ended March 31, 2003;
  (b)
  Item 1 of Registration Statement of the Company
  on Form 8-A dated June 28, 1991, as amended by a Registration Statement of the Company on
  Form 8-A/A dated January 17, 1997; and
  (c)
  Item 1 of Registration Statement of the Company
  on Form 8-A dated May 2, 2003.
  All documents filed by the Company pursuant to Sections 13(a), 13(c), 14
  or 15(d) of the Exchange Act, after the date of this Registration Statement and
  prior to the termination of the offering, shall be deemed to be incorporated by
  reference herein and to be part hereof from the date of filing such documents.
  Any statement contained herein or in a document incorporated by reference or
  deemed to be incorporated by reference herein shall be deemed to be modified or
  superseded for purposes of this Registration Statement to the extent that such
  statement is modified or superseded by any other subsequently filed document
  which is incorporated or is deemed to be incorporated by reference herein. Any
  such statement so modified or superseded shall not be deemed, except as so
  modified or superseded, to constitute a part of this Registration Statement.
  Item 4. Description of Securities.
  Not applicable.
  Item 5. Interests of Named Experts and Counsel.
  Morris Cheston, Jr., Esquire, Secretary of the Company and Jennifer L.
  Miller, Esquire, Secretary of Alkermes Investments, Inc., a wholly-owned
  subsidiary of Alkermes, Inc., are both partners in the law firm of Ballard
  Spahr Andrews & Ingersoll, LLP which has given an opinion passing upon the
  validity of the securities being registered hereby.
  Item 6. Indemnification of Officers and Directors.
  The Pennsylvania Business Corporation Law of 1988, as amended, authorizes
  the Company to grant indemnification to directors and officers in terms
  sufficiently broad to permit such indemnification under certain circumstances
  for liabilities (including reimbursement for expenses incurred) arising under
  the Securities Act of 1933, as amended. In addition, the Company has also
  obtained Directors' and Officers' Liability Insurance in the amount of
  $20,000,000 which insures its officers and directors against certain
  liabilities such persons may incur in their capacities as officers or directors
  of the Company.
  Article 5 of the Company's By-Laws provides as follows:
  II-1
  Table of Contents
  5.1 INDEMNIFICATION OF DIRECTORS, OFFICERS, AND OTHER PERSONS. The
  Corporation shall indemnify any director, officer, employee or agent of the
  Corporation or any of its subsidiaries who was or is an "authorized
  representative" of the Corporation (which shall mean, for the purpose of this
  Article, a director or officer of the Corporation, or a person serving at the
  request of the Corporation as a director, officer, partner, fiduciary or
  trustee of another corporation, partnership, joint venture, trust, employee
  benefit plan or other enterprise) and who was or is a "party" (which shall
  include for purposes of this Article the giving of testimony or similar
  involvement) or is threatened to be made a party to any "proceeding" (which
  shall mean for purposes of this Article any threatened, pending or completed
  action, suit, appeal or other proceeding of any nature, whether civil,
  criminal, administrative or investigative, whether formal or informal, and
  whether brought by or in the right of the Corporation, its shareholders or
  otherwise) by reason of the fact that such person was or is an authorized
  representative of the Corporation to the fullest extent permitted by law,
  including without limitation indemnification against expenses (which shall
  include for purposes of this Article attorneys' fees and disbursements),
  damages, punitive damages, judgments, penalties, fines and amounts paid in
  settlement actually and reasonably incurred by such person in connection with
  such proceeding unless the act or failure to act giving rise to the claim is
  finally determined by a court to have constituted willful misconduct or
  recklessness. If an authorized representative is not entitled to
  indemnification in respect of a portion of any liabilities to which such person
  may be subject, the Corporation shall nonetheless indemnify such person to the
  maximum extent for the remaining portion of the liabilities.
  5.2 ADVANCEMENT OF EXPENSES. The Corporation shall pay the expenses
  (including attorneys' fees and disbursements) actually and reasonably incurred
  in defending a proceeding on behalf of any person entitled to indemnification
  under Section 5.1 in advance of the final disposition of such proceeding upon
  receipt of an undertaking by or on behalf of such person to repay such amount
  if it shall ultimately be determined that such person is not entitled to be
  indemnified by the Corporation as authorized in this Article and may pay such
  expenses in advance on behalf of any employee or agent on receipt of a similar
  undertaking. The financial ability of such authorized representative to make
  such repayment shall not be prerequisite to the making of an advance.
  5.3 EMPLOYEE BENEFIT PLANS. For purposes of this Article, the Corporation
  shall be deemed to have requested an officer, director, employee or agent to
  serve as fiduciary with respect to an employee benefit plan where the
  performance by such person of duties to the Corporation also imposes duties on,
  or otherwise involves services by, such person as a fiduciary with respect to
  the plan; excise taxes assessed on an authorized representative with respect to
  any transaction with an employee benefit plan shall be deemed "fines"; and
  action taken or omitted by such person with respect to an employee benefit plan
  in the performance of duties for a purpose reasonably believed to be in the
  interest of the participants and beneficiaries of the plan shall be deemed to
  be for a purpose which is not opposed to the best interests of the Corporation.
  5.4 SECURITY FOR INDEMNIFICATION OBLIGATIONS. To further effect, satisfy
  or secure the indemnification obligations provided herein or otherwise, the
  Corporation may maintain insurance, obtain a letter of credit, act as
  self-insurer, create a reserve, trust, escrow, cash collateral or other fund or
  account, enter into indemnification agreements, pledge or grant a security
  interest in any assets or properties of the Corporation, or use any other
  mechanism or arrangement whatsoever in such amounts, at such costs, and upon
  such other terms and conditions as the Board of Directors shall deem
  appropriate.
  5.5 RELIANCE UPON PROVISIONS. Each person who shall act as an authorized
  representative of the Corporation shall be deemed to be doing so in reliance
  upon the rights of indemnification provided by this Article.
  II-2
  Table of Contents
  5.6 AMENDMENT OR REPEAL. All rights of indemnification under this Article
  shall be deemed a contract between the Corporation and the person entitled to
  indemnification under this Article pursuant to which the Corporation and each
  such person intend to be legally bound. Any repeal, amendment or modification
  hereof shall be prospective only and shall not limit, but may expand, any
  rights or obligations in respect of any proceeding whether commenced prior to
  or after such change to the extent such proceeding pertains to actions or
  failures to act occurring prior to such change.
  5.7 SCOPE OF ARTICLE. The indemnification, as authorized by this Article,
  shall not be deemed exclusive of any other rights to which those seeking
  indemnification or advancement of expenses may be entitled under any statute,
  agreement, vote of shareholders or disinterested directors or otherwise, both
  as to action in an official capacity and as to action in any other capacity
  while holding such office. The indemnification and advancement of expenses
  provided by, or granted pursuant to, this Article shall continue as to a person
  who has ceased to be an officer, director, employee or agent in respect of
  matters arising prior to such time, and shall inure to the benefit of the
  heirs, executors and administrators of such person.
  Item 7. Exemption from Registration Claimed.
  Not applicable.
  Item 8. Exhibits.
  4.1
  Specimen of Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4 to the Registrant's
  Registration Statement on Form S-1 as amended (File No. 33-40250)).
  4.2
  Specimen of Non-Voting Common Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit 4.4 to the Registrant's
  Report on Form 10-K for the fiscal year ended March 31, 1999).
  4.3
  Specimen of 2002 Preferred Stock Certificate of Alkermes,
  Inc. (Incorporated by reference to Exhibit 4.1 to the Registrant's
  Current Report on Form 8-K filed on December 13, 2002).
  4.4
  Indenture, dated as of February 18, 2000, between Alkermes,
  Inc. and State Street Bank and Trust Company, as Trustee (3.75%
  Subordinated Notes). (Incorporated by reference to Exhibit 4.6 to
  the Registrant's Registration Statement on Form S-3, as amended
  (File No. 333-31354)).
  4.5
  Form of Indenture between Alkermes, Inc. and State Street
  Bank and Trust Company, as Trustee (6.52% Senior Notes).
  (Incorporated by reference to Exhibit 4.1 to the Registrant's
  Registration Statement on Form S-1, as amended (File No.
  333-101464)).
  4.6
  Rights Agreement, dated February 7, 2003, as amended, between
  Alkermes, Inc. and EquiServe Trust Co., N.A., as Rights Agent.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement
  on Form 8-A filed on May 2, 2003).
  5
  Opinion of Ballard Spahr Andrews & Ingersoll, LLP as to the
  legality of the securities to be offered.
  23.1
  Consent of Ballard Spahr Andrews & Ingersoll, LLP (included as part of Exhibit 5).
  II-3
  Table of Contents
  23.2
  Independent Auditors' Consent of Deloitte & Touche LLP.
  23.3
  Consent of Independent Auditors of Ernst & Young LLP.
  24
  Power of Attorney (included in signature page).
  99
  Alkermes, Inc. 2002 Restricted Stock Award Plan (Incorporated
  by reference to Exhibit 10.2 to the Registrant's Quarterly Report on
  Form 10-Q for the quarter ended September 30, 2002).
  Item 9. Undertakings
  The undersigned registrant hereby undertakes:
  (1)  To file, during any period in which offers or sales are being made, a
  post-effective amendment to this registration statement:
  (i)  To include any prospectus required by section 10(a)(3) of the
  Securities Act of 1933;
  (ii)  To reflect in the prospectus any facts or events arising after the
  effective date of the registration statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a
  fundamental change in the information set forth in the registration statement.
  Notwithstanding the foregoing, any increase or decrease in volume of securities
  offered (if the total dollar value of securities offered would not exceed that
  which was registered) and any deviation from the low or high end of the
  estimated maximum offering range may be reflected in the form of prospectus
  filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
  changes in volume and price represent no more than a 20% change in the maximum
  aggregate offering price set forth in the "Calculation of Registration Fee"
  table in the effective registration statement;
  (iii)  To include any material information with respect to the plan of
  distribution not previously disclosed in the registration statement or any
  material change to such information in the registration statement;
  Provided, however,
  that paragraphs (1)(i) and (1)(ii) do not apply
  if the registration statement is on Form S-3 or Form S-8, and the information
  required to be included in a post-effective amendment by those paragraphs is
  contained in periodic reports filed by the registrant pursuant to Section 13 or
  Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by
  reference in the registration statement.
  (2)  That, for the purpose of determining any liability under the
  Securities Act of 1933, each such post-effective amendment shall be deemed to
  be a new registration statement relating to the securities offered therein, and
  the offering of such securities at that time shall be deemed to be the initial
  bona fide offering thereof.
  (3)  To remove from registration by means of a post-effective amendment any
  of the securities being registered which remain unsold at the termination of
  the offering.
  The Company hereby undertakes that, for purposes of determining any
  liability under the Securities Act of 1933, each filing of the Company's annual
  report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange
  Act of 1934 (and, where applicable, each filing of an employee benefit
  II-4
  Table of Contents
  plan's annual report pursuant to Section 15(d) of the Securities Exchange
  Act of 1934) that is incorporated by reference in the registration statement
  shall be deemed to be a new registration statement relating to the securities
  offered therein, and the offering of such securities at that time shall be
  deemed to be the initial bona fide offering thereof.
  Insofar as indemnification for liabilities arising under the Securities
  Act of 1933 may be permitted to directors, officers and controlling persons of
  the registrant pursuant to the foregoing provisions, or otherwise, the
  registrant has been advised that in the opinion of the Securities and Exchange
  Commission such indemnification is against public policy as expressed in the
  Act and is, therefore, unenforceable. In the event that a claim for
  indemnification against such liabilities (other than the payment by the
  registrant of expenses incurred or paid by a director, officer or controlling
  person of the registrant in the successful defense of any action, suit or
  proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the registrant will, unless in
  the opinion of its counsel the matter has been settled by controlling
  precedent, submit to a court of appropriate jurisdiction the question whether
  such indemnification by it is against public policy as expressed in the Act and
  will be governed by the final adjudication of such issue.
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  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the
  requirements for filing on Form S-8 and has duly caused this Registration
  Statement to be signed on its behalf by the undersigned, thereunto duly
  authorized, in the City of Cambridge, Commonwealth of Massachusetts, on July
  21, 2003.
  ALKERMES, INC.
  By
  /s/ Richard F. Pops
  Richard F. Pops
  Chief Executive Officer
  Pursuant to the requirements of the Securities Act of 1933, this
  Registration Statement has been signed below by the following persons in the
  capacities and on the dates indicated.
  Each person whose signature appears below in so signing also makes,
  constitutes and appoints Richard F. Pops and James M. Frates, and each of them,
  his true and lawful attorney-in-fact, with full power of substitution, for him
  in any and all capacities, to execute and cause to be filed with the Securities
  and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in
  connection therewith, and hereby ratifies and confirms all that said
  attorney-in-fact or his substitute or substitutes may do or cause to be done by
  virtue hereof.
  Signature
  Title
  Date
  Michael A. Wall
  Director and
  Chairman of the
  Board
  /s/ Richard F. Pops
  Richard F. Pops
  Director and Chief
  Executive Officer
  (Principal
  Executive Officer)
  July 21, 2003
  /s/ Robert A. Breyer
  Robert A. Breyer
  Director
  July 21, 2003
  /s/ James M. Frates
  James M. Frates
  Vice President, Chief
  Financial Officer and
  Treasurer
  (Principal Financial Officer
  and Principal Accounting
  Officer)
  July 21, 2003
  II-6
  Table of Contents
  Signature
  Title
  Date
  /s/ Floyd E. Bloom
  Floyd E. Bloom
  Director
  July 21, 2003
  /s/ John K. Clarke
  John K. Clarke
  Director
  July 21, 2003
  /s/ Alexander Rich
  Alexander Rich
  Director
  July 21, 2003
  /s/ Paul Schimmel
  Paul Schimmel
  Director
  July 21, 2003
  /s/ Gerri Henwood
  Gerri Henwood
  Director
  July 21, 2003
  /s/ Paul J. Mitchell
  Paul J. Mitchell
  Director
  July 21, 2003
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  Table of Contents
  EXHIBIT INDEX
  Number
  Exhibit
  4.1
  Specimen of Common Stock Certificate of Alkermes, Inc. (Incorporated by
  reference to Exhibit 4 to the Registrant's Registration Statement on Form
  S-1 as amended (File No. 33-40250)).
  4.2
  Specimen of Non-Voting Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4.4 to the Registrant's Report on
  Form 10-K for the fiscal year ended March 31, 1999).
  4.3
  Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's Current
  Report on Form 8-K filed on December 13, 2002).
  4.4
  Indenture, dated as of February 18, 2000, between Alkermes, Inc. and
  State Street Bank and Trust Company, as Trustee (3.75% Subordinated
  Notes). (Incorporated by reference to Exhibit 4.6 to the Registrant's
  Registration Statement on Form S-3, as amended (File No. 333-31354)).
  4.5
  Form of Indenture between Alkermes, Inc. and State Street Bank and Trust
  Company, as Trustee (6.52% Senior Notes). (Incorporated by reference to
  Exhibit 4.1 to the Registrant's Registration Statement on Form S-1, as
  amended (File No. 333-101464)).
  4.6
  Rights Agreement, dated February 7, 2003, as amended, between Alkermes,
  Inc. and EquiServe Trust Co., N.A., as Rights Agent. (Incorporated by
  reference to Exhibit 4.1 to the Registrant's Registration Statement on Form 8-A filed on
  May 2, 2003).
  5
  Opinion of Ballard Spahr Andrews & Ingersoll, LLP as to the legality of
  the securities to be offered.
  23.1
  Consent of Ballard Spahr Andrews & Ingersoll, LLP (included as part of Exhibit 5).
  23.2
  Independent Auditors' Consent of Deloitte & Touche LLP.
  23.3
  Consent of Independent Auditors of Ernst & Young LLP.
  24
  Power of Attorney (included in signature page).
  99
  Alkermes, Inc. 2002 Restricted Stock Award Plan (Incorporated by
  reference to Exhibit 10.2 to the Registrant's Quarterly Report on Form
  10-Q for the quarter ended September 30, 2002).