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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">As filed with the Securities and Exchange Commission on March&nbsp;11, 2009
  </DIV>
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 3pt">REGISTRATION
  NO. 333 - &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 6pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT<BR>
  under the<BR>
  SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>ALTUS PHARMACEUTICALS INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(<I>Exact Name of Registrant as Specified in Its Charter)</I></DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-3573277</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(<I>State or Other Jurisdiction <BR>
  of Incorporation or Organization</I>)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(<I>I.R.S. Employer<BR>
  Identification No.</I>)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>333 Wyman Street<BR>
  Waltham, MA 02451</B><BR>
  (<I>Address, Including Zip Code, of Principal Executive Offices</I>)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan,
  as <BR>amended<BR>
  Inducement Option Grant Outside of a Plan</B><BR>
  <I>(Full Title of the Plan)</I></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Georges Gemayel, Ph.D.<BR>
  President and Chief Executive Officer<BR>
  Altus Pharmaceuticals Inc.<BR>
  333 Wyman Street<BR>
  Waltham, MA 02451<BR>
  (781)&nbsp;373-6000</B><BR>
  (<I>Name, Address and Telephone Number, Including Area Code, of Agent For Service</I>)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">with copies to:<BR>
  <B>Paul M. Kinsella, Esq.<BR>
  Ropes &#038; Gray LLP<BR>
  One International Place<BR>
  Boston, Massachusetts 02110</B></DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &#147;large accelerated filer,&#148; &#147;accelerated filer&#148; and &#147;smaller reporting company&#148; in Rule 12b-2 of the Exchange Act. (Check one):</DIV>
  
  <TABLE width="100%" style="font-size: 10pt; margin-top: 0pt">
  <TR>
  <TD>Large accelerated filer&nbsp;<FONT face="Wingdings">&#111;</FONT></TD>
  <TD align="center">Accelerated filer&nbsp;<FONT face="Wingdings">&#254;</FONT>&nbsp;</TD>
  <TD align="center"><br>Non-accelerated filer&nbsp;<FONT face="Wingdings">&#111;</FONT>
  <BR>(Do not check if a smaller reporting company)</TD>
  <TD align="right">Smaller reporting company&nbsp;<FONT face="Wingdings">&#111;</FONT></TD>
  </TR>
  </TABLE>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CALCULATION OF REGISTRATION FEE</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom" style="font-size: 1pt">
      <TD width="1%">&nbsp;</TD>
      <TD width="34%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">offering price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">aggregate</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">securities to be registered</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">registered</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">per share</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">offering price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="3">registration fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, $0.01 par value</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">1,150,617</TD>
  
  <TD nowrap style="border-top: 2px solid #000000"><SUP style="font-size: 85%; vertical-align: text-bottom">(1)</SUP></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">0.20</TD>
  
  <TD nowrap style="border-top: 2px solid #000000"><SUP style="font-size: 85%; vertical-align: text-bottom">(2)</SUP></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">230,123</TD>
  
  <TD nowrap style="border-top: 2px solid #000000"><SUP style="font-size: 85%; vertical-align: text-bottom">(2)</SUP></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">10.00</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, $0.01 par value</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD nowrap align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">340,000</TD>
  
  <TD nowrap style="border-top: 2px solid #000000"><SUP style="font-size: 85%; vertical-align: text-bottom">(3)</SUP></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">4.07</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">1,383,800</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">55.00</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Total</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">1,490,617</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">1,613,923</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="right" style="border-top: 2px solid #000000">$</TD>
      <TD align="right" style="border-top: 2px solid #000000">65.00</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Represents additional shares which may be sold upon the exercise of options and the issuance of stock awards which may
  hereafter be granted under the Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan, as amended (the &#147;Plan&#148;). The maximum number of shares which may be sold upon the exercise of options or issuance of
  stock awards granted under the Plan is subject to adjustment in accordance with certain anti-dilution and other provisions of
  the Plan. Accordingly, pursuant to Rule&nbsp;416 under the Securities Act of 1933, as amended (the &#147;Securities Act&#148;), this
  Registration Statement covers, in addition to the number of shares stated above, an indeterminate number of shares which may
  be subject to grant or otherwise issuable upon the operation of any such anti-dilution and other provisions.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>This calculation is made solely for the purpose of determining the registration fee pursuant to the provisions of Rule 457(c)
  and (h)&nbsp;under the Securities Act. The fee is calculated on the basis of the average of the high and low sale prices per share
  of the Common Stock on The Nasdaq Global Market as of a date (March&nbsp;4, 2009) within five business days prior to filing this
  Registration Statement.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>Represents shares of Common Stock reserved for issuance upon the exercise of inducement options (the &#147;Inducement Grant&#148;)
  granted on June&nbsp;2, 2008 to Dr.&nbsp;Georges Gemayel in connection with his employment.</TD>
  </TR>
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
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  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART I</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#001">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;3. Incorporation of Documents by Reference.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;4. Description of Securities.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;6. Indemnification of Directors and Officers.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;7. Exemption from Registration Claimed.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;8. Exhibits.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#008">Item&nbsp;9. Undertakings.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#009">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#010">INDEX OF EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b74610apexv5w1.htm">Ex-5.1 Opinion of Ropes & Gray LLP.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b74610apexv23w2.htm">Ex-23.2 Consent of Deloitte & Touche LLP.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b74610apexv23w3.htm">Ex-23.3 Consent of Ernst & Young LLP.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b74610apexv99w3.htm">Ex-99.3 Non-Qualified Stock Option Agreement</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link1 "PART I" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
  
  </DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Information required by Part&nbsp;I to be contained in the Section 10(a) prospectus is omitted from this
  Registration Statement in accordance with Rule&nbsp;428 under the
  Securities Act of 1933, as amended, and
  the Note to Part&nbsp;I of Form S-8.
  </DIV>
  
  <!-- link1 "PART II" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  </DIV>
  <!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(1)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended
  December&nbsp;31, 2008 filed on March&nbsp;11, 2009 (File No.&nbsp;000-51711);</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(2)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Current Reports on Form 8-K filed on January&nbsp;6, 2009,
  January&nbsp;26, 2009 and February&nbsp;26, 2009 (File No.&nbsp;000-51711); and</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="3%" nowrap align="left">(3)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Registrant&#146;s Common Stock contained in the
  Registrant&#146;s Registration Statement on Form 8-A, filed with the
  Commission on January&nbsp;11, 2006 (File No.&nbsp;000-51711), including any
  amendment or report filed for the purpose of updating such
  description.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">All reports and other documents filed by the Registrant after the date hereof pursuant to Sections
  13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, prior to the filing of a
  post-effective amendment which indicates that all securities offered hereby have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference
  herein and to be part hereof from the date of filing of such reports and documents. Any statement
  contained in a document incorporated or deemed to be incorporated by reference herein shall be
  deemed to be modified or superseded for the purposes of this Registration Statement to the extent
  that a statement contained herein or in any other subsequently filed document which also is or is
  deemed to be
  incorporated by reference herein modifies or supersedes such statement. Any statement so modified
  or superseded shall not be deemed, except as so modified or superseded, to constitute a part of
  this Registration Statement.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link2 "Item&nbsp;4. Description of Securities." -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;4. Description of Securities.</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Not applicable.
  </DIV>
  
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Not applicable.
  </DIV>
  
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers." -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the Delaware General Corporation Law (&#147;DGCL&#148;) provides that a corporation may
  indemnify any person who was or is a party or is threatened to be made a party to any threatened,
  pending or completed action, suit or proceeding, whether civil, criminal or investigative (other
  than an action by or in the right of the corporation) by reason of the fact that he is or was a
  director, officer, employee or agent of the corporation, or is or was serving at the request of the
  corporation as a director, officer, employee or agent of another corporation, partnership, joint
  venture, trust or other enterprise, against expenses (including attorney&#146;s fees), judgments, fines
  and amounts paid in settlement actually and reasonably incurred by him in connection with such
  action, suit or proceeding if he acted in good faith and in a manner he reasonably believed to be
  in or not opposed to the best interests of the corporation, and, with respect to any criminal
  action or proceeding, had no reasonable cause to believe his conduct was unlawful. Section&nbsp;145
  further provides that a corporation similarly may indemnify any such person serving in any such
  capacity who was or is a party or is threatened to be made a party to any threatened, pending or
  completed action or suit by or in the right of the corporation to procure a judgment in its favor,
  against expenses actually and reasonably incurred in connection with the defense or settlement of
  such action or suit if he acted in good faith and in a manner he reasonably believed to be in or
  not opposed to the best interests of the corporation and except that no indemnification shall be
  made in respect of any claim, issue or matter as to which such person shall have been adjudged to
  be liable to the corporation unless and only to the extent that the Delaware Court of Chancery or
  such other court in which such action or suit was brought shall determine upon application that,
  despite the adjudication of liability but in view of all the circumstances of the case, such person
  is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or
  such other court shall deem proper.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;102(b)(7) of the DGCL permits a corporation to include in its certificate of
  incorporation a provision eliminating or limiting the personal liability of a director to the
  corporation or its stockholders for monetary damages for breach of fiduciary duty as a director,
  provided that such provision shall not eliminate or limit the liability of a director (i)&nbsp;for any
  breach of the director&#146;s duty of loyalty to the corporation or its stockholders, (ii)&nbsp;for acts or
  omissions not in good faith or which involve intentional misconduct or a knowing violation of law,
  (iii)&nbsp;under Section&nbsp;174 of the DGCL (relating to unlawful payment of dividends and unlawful stock
  purchase and redemption) or (iv)&nbsp;for any transaction from which the director derived an improper
  personal benefit.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant&#146;s restated certificate of incorporation and restated bylaws provide that each
  person who was or is made a party or is threatened to be made a party to any action, suit or
  proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he
  or she is or was one of the Registrant&#146;s directors or officers or is or was serving at the
  Registrant&#146;s request as a director, officer, employee or agent of another corporation, or of a
  partnership, joint venture, trust or other enterprise, shall be indemnified by the Registrant to
  the fullest extent authorized by the DGCL against all expense, liability and loss (including
  attorneys&#146; fees, judgments, fines or penalties and amounts paid in settlement) reasonably incurred
  in connection with legal proceedings. A director or officer will not receive indemnification if he
  or she is found not to have acted in good faith and in a manner he or she reasonably believed to be
  in, or not opposed to, the Registrant&#146;s best interest.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant carries insurance policies insuring its directors and officers against certain
  liabilities that they may incur in their capacity as directors and officers. In addition, the
  Registrant has entered into indemnification agreements with its directors and executive officers.
  These agreements contain presumptions and procedures
  designed to ensure that the indemnification and advancement rights granted to each indemnitee in
  these agreements will be provided on a timely basis. Each agreement provides that the Registrant&#146;s
  obligations under the agreement
  will continue during the time the indemnitee serves the Registrant
  and continues thereafter so long as the indemnitee is subject to any possible proceeding by reason
  of the indemnitee&#146;s service to the Registrant.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link2 "Item&nbsp;7. Exemption from Registration Claimed." -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;7. Exemption from Registration Claimed.</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Not Applicable.
  </DIV>
  
  <!-- link2 "Item&nbsp;8. Exhibits." -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8. Exhibits.</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="88%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" colspan="3">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" colspan="3">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR style="font-size: 1px">
      <TD colspan="3" nowrap valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" nowrap valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.1</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Restated Certificate of Incorporation of the Registrant. Filed as
  Exhibit&nbsp;3.1 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for the
  fiscal year ended December&nbsp;31, 2006, as amended (File No.
  000-51711) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.2</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Restated By-laws of the Registrant. Filed as Exhibit&nbsp;3.4 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File
  No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.3</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Common Stock Certificate. Filed as Exhibit&nbsp;4.1 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File
  No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.4</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Amended and Restated Investor Rights Agreement, dated as of May&nbsp;21,
  2004. Filed as Exhibit&nbsp;4.3 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.5</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Common Stock Warrant to Cystic Fibrosis Foundation
  Therapeutics, Inc. Filed as Exhibit&nbsp;4.9 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.
  333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.6</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Common Stock Warrant to SG Cowen &#038; Co. Filed as Exhibit
  4.11 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as
  amended (File No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.7</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Series&nbsp;B Preferred Stock Warrant, as amended, together with
  a schedule of warrant holders. Filed as Exhibit&nbsp;4.12 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File
  No.&nbsp;333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.8</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Series&nbsp;C Preferred Stock Warrant, together with a schedule
  of warrant holders. Filed as Exhibit&nbsp;4.13 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.
  333-129037) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.9</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Common Stock Purchase Agreement, dated as of December&nbsp;19, 2006,
  between the Registrant and Genentech, Inc. Filed as Exhibit&nbsp;10.1 to
  the Registrant&#146;s Form&nbsp;8-K filed with the Securities and Exchange
  Commission on March&nbsp;1, 2007 (File No.&nbsp;000-51711) and incorporated
  herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.10</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Registration Rights Agreement, dated as of February&nbsp;27, 2007,
  between the Registrant and Genentech, Inc. Filed as Exhibit&nbsp;10.2 to
  the Registrant&#146;s Form&nbsp;8-K filed with the Securities and Exchange
  Commission on March&nbsp;1, 2007 (File No.&nbsp;000-51711) and incorporated
  herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(4.11</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Common Stock Warrant issued to Adage Capital Partners, L.P.
  Filed as Exhibit&nbsp;4.5 to the Registrant&#146;s Registration Statement on
  Form&nbsp;S-3 (File No.&nbsp;333-141414) and incorporated herein by
  reference.</DIV></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="88%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" colspan="3">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" colspan="3">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR style="font-size: 1px">
      <TD colspan="3" nowrap valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" nowrap valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(5.1</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Opinion of Ropes &#038; Gray LLP. (Filed herewith).</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(23.1</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Ropes &#038; Gray LLP. (Contained in Exhibit&nbsp;5.1).</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(23.2</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Deloitte &#038; Touche LLP. (Filed herewith).</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(23.3</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Ernst &#038; Young LLP. (Filed herewith).</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(24.1</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Power of Attorney to file future amendments. (Set forth on the signature page of this Registration Statement).</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(99.1</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee,
  Director and Consultant Stock Plan, as amended. Filed as Exhibit
  10.4 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for the fiscal
  year ended December&nbsp;31, 2006, as amended (File No.&nbsp;000-51711) and
  incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(99.2</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Offer Agreement between the Registrant and Georges Gemayel, Ph.D.,
  dated May&nbsp;21, 2008. Filed as Exhibit&nbsp;10.1 to the Registrant&#146;s Form
  8-K filed with the Securities and Exchange Commission on May&nbsp;27,
  2008 (File No.&nbsp;000-51711) and incorporated herein by reference.</DIV></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">&nbsp;</TD>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
  </TR>
  <TR valign="bottom">
      <TD nowrap align="right" valign="top">&nbsp;</TD>
      <TD align="right" valign="top">(99.3</TD>
      <TD nowrap valign="top">)</TD>
      <TD>&nbsp;</TD>
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Altus Pharmaceuticals, Inc. Non-Qualified Stock Option Agreement, dated June&nbsp;2, 2008. (Filed herewith).</DIV></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <!-- link2 "Item&nbsp;9. Undertakings." -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;9. Undertakings.</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">(a)&nbsp;&nbsp;The undersigned registrant hereby undertakes:
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">1. To file, during any period in which offers or sales are being made, a post-effective amendment
  to this registration statement:
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">(i)&nbsp;To include any prospectus required by section 10(a)(3) of the Securities Act of 1933;
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">(ii)&nbsp;To reflect in the prospectus any facts or events arising after the effective date of the
  registration statement (or the most recent post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the information set forth in the registration
  statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
  (if the total dollar value of securities offered would not exceed that which was registered) and
  any deviation from the low or high end of the estimated maximum offering range may be reflected in
  the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
  changes in volume and price represent no more than 20&nbsp;percent change in the maximum aggregate
  offering price set forth in the &#147;Calculation of Registration Fee&#148; table in the effective
  registration statement.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">(iii)&nbsp;To include any material information with respect to the plan of distribution not previously
  disclosed in the registration statement or any material change to such information in the
  registration statement.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt"><I>Provided, however</I>, That paragraphs (a)(1)(i) and (a)(1)(ii) above do not apply if the information
  required to be included in a post-effective amendment by those paragraphs is contained in reports
  filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d)
  of the Securities Exchange Act of 1934 that are incorporated by reference in the registration
  statement.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">2.&nbsp;That, for the purpose of determining any liability under the Securities Act of 1933, each such
  post-effective amendment shall be deemed to be a new registration statement relating to the
  securities offered therein, and the offering of such securities at that time shall be deemed to be
  the initial bona fide offering thereof.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">3. To remove from registration by means of a post-effective amendment any of the securities being
  registered which remain unsold at the termination of the offering.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">(b)&nbsp;&nbsp;The undersigned registrant hereby undertakes that, for purposes of determining any liability under
  the Securities Act of 1933, each filing of the registrant&#146;s annual report pursuant to section 13(a)
  or section 15(d) of the Securities Exchange Act of 1934 that is incorporated by reference in the
  registration statement shall be deemed to be a new registration statement relating to the
  securities offered therein, and the offering of such securities at that time shall be deemed to be
  the initial bona fide offering thereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">(c)&nbsp;&nbsp;Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the registrant pursuant to the
  foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the
  Commission such indemnification is against public policy as expressed in the Act and is, therefore,
  unenforceable. In the event that a claim for indemnification against such liabilities (other than
  the payment by the registrant of expenses incurred or paid by a director, officer or controlling
  person of the registrant in the successful defense of any action, suit or proceeding) is asserted
  by such director, officer or controlling person in connection with the securities being registered,
  the registrant will, unless in the opinion of its counsel the matter has been settled by
  controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Act and will be governed by the
  final adjudication of such issue.
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="009"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in Waltham, Massachusetts on March 10, 2009.
  </DIV>
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">ALTUS PHARMACEUTICALS INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ GEORGES GEMAYEL
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Georges Gemayel, Ph.D.&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">Power Of Attorney
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Each person whose signature appears below constitutes and appoints Georges Gemayel, Ph. D. and
  Thomas J. Phair, Jr., and each of them singly, his true and lawful attorneys-in-fact and agents,
  with full power of substitution and resubstitution in each of them singly, for him and in his name,
  place and stead, and in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement on Form S-8 of Altus Pharmaceuticals
  Inc., and to file the same, with all exhibits thereto and other documents in connection therewith,
  with the Securities and Exchange Commission, granting to the attorneys-in-fact and agents, and each
  of them, full power and authority to do and perform each and every act and thing requisite or
  necessary to be done in or about the premises, as full to all intents and purposes as he might or
  could do in person, hereby ratifying and confirming all that the attorneys-in-fact and agents or
  any of each of them or their substitute may lawfully do or cause to be done by virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been
  signed by the following persons in the capacities and on the dates indicated.
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="38%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="38%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="20%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ GEORGES GEMAYEL
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">President, Chief Executive Officer and
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">March&nbsp;10, 2009</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Georges Gemayel, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;Director
  (principal executive officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ JONATHAN I. LIEBER
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Senior Vice President, Chief Financial Officer and
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">March&nbsp;10, 2009</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Jonathan I. Lieber
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;Treasurer
  (principal
  financial and accounting officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ DAVID D. PENDERGAST
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">March&nbsp;10, 2009</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  David D. Pendergast, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ MANUEL A. NAVIA
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">March&nbsp;10, 2009</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Manuel A. Navia, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ HARRY H. PENNER, JR.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">March&nbsp;10, 2009</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Harry H. Penner, Jr.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ JOHN P. RICHARD
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">March&nbsp;10, 2009</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  John P. Richard
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ JONATHAN D. ROOT
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">March&nbsp;10, 2009</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Jonathan D. Root, M.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ MICHAEL S. WYZGA
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">March&nbsp;10, 2009</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Michael S. Wyzga
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "INDEX OF EXHIBITS" -->
  <DIV align="left"><A NAME="010"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX OF EXHIBITS</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="7%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="91%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant. Filed as
  Exhibit&nbsp;3.1 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for the
  fiscal year ended December&nbsp;31, 2006, as amended (File No.
  000-51711) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated By-laws of the Registrant. Filed as Exhibit&nbsp;3.4 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File
  No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Certificate. Filed as Exhibit&nbsp;4.1 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File
  No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.4)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated Investor Rights Agreement, dated as of May&nbsp;21,
  2004. Filed as Exhibit&nbsp;4.3 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Cystic Fibrosis Foundation
  Therapeutics, Inc. Filed as Exhibit&nbsp;4.9 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.
  333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.6)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to SG Cowen &#038; Co. Filed as Exhibit
  4.11 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as
  amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.7)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Series&nbsp;B Preferred Stock Warrant, as amended, together with
  a schedule of warrant holders. Filed as Exhibit&nbsp;4.12 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File
  No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.8)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Series&nbsp;C Preferred Stock Warrant, together with a schedule
  of warrant holders. Filed as Exhibit&nbsp;4.13 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.
  333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.9)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Common Stock Purchase Agreement, dated as of December&nbsp;19, 2006,
  between the Registrant and Genentech, Inc. Filed as Exhibit&nbsp;10.1 to
  the Registrant&#146;s Form&nbsp;8-K filed with the Securities and Exchange
  Commission on March&nbsp;1, 2007 (File No.&nbsp;000-51711) and incorporated
  herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.10)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Registration Rights Agreement, dated as of February&nbsp;27, 2007,
  between the Registrant and Genentech, Inc. Filed as Exhibit&nbsp;10.2 to
  the Registrant&#146;s Form&nbsp;8-K filed with the Securities and Exchange
  Commission on March&nbsp;1, 2007 (File No.&nbsp;000-51711) and incorporated
  herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.11)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant issued to Adage Capital Partners, L.P.
  Filed as Exhibit&nbsp;4.5 to the Registrant&#146;s Registration Statement on
  Form&nbsp;S-3 (File No.&nbsp;333-141414) and incorporated herein by
  reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(5.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Ropes &#038; Gray LLP. (Filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ropes &#038; Gray LLP.
  (Contained in Exhibit&nbsp;5.1).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP. (Filed herewith).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="7%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="91%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP. (Filed herewith).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(24.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney to file future amendments. (Set forth on the
  signature page of this Registration Statement).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee,
  Director and Consultant Stock Plan, as amended. Filed as Exhibit
  10.4 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for the fiscal
  year ended December&nbsp;31, 2006, as amended (File No.&nbsp;000-51711) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Offer Agreement between the Registrant and Georges Gemayel, Ph.D.,
  dated May&nbsp;21, 2008. Filed as Exhibit&nbsp;10.1 to the Registrant&#146;s Form
  8-K filed with the Securities and Exchange Commission on May&nbsp;27,
  2008 (File No.&nbsp;000-51711) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Altus Pharmaceuticals, Inc. Non-Qualified Stock Option Agreement,
  dated June&nbsp;2, 2008. (Filed herewith).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
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  </HTML>
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text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on March 11, 2009
  REGISTRATION
  NO. 333 -
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  under the
  SECURITIES ACT OF 1933
  ALTUS PHARMACEUTICALS INC.
  (
  Exact Name of Registrant as Specified in Its Charter)
  Delaware
  04-3573277
  (
  State or Other Jurisdiction
  of Incorporation or Organization
  )
  (
  I.R.S. Employer
  Identification No.
  )
  333 Wyman Street
  Waltham, MA 02451
  (
  Address, Including Zip Code, of Principal Executive Offices
  )
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan,
  as
  amended
  Inducement Option Grant Outside of a Plan
  (Full Title of the Plan)
  Georges Gemayel, Ph.D.
  President and Chief Executive Officer
  Altus Pharmaceuticals Inc.
  333 Wyman Street
  Waltham, MA 02451
  (781) 373-6000
  (
  Name, Address and Telephone Number, Including Area Code, of Agent For Service
  )
  with copies to:
  Paul M. Kinsella, Esq.
  Ropes & Gray LLP
  One International Place
  Boston, Massachusetts 02110
  Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act. (Check one):
  Large accelerated filer
  o
  Accelerated filer
  þ
  Non-accelerated filer
  o
  (Do not check if a smaller reporting company)
  Smaller reporting company
  o
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  maximum
  maximum
  Title of
  Amount to be
  offering price
  aggregate
  Amount of
  securities to be registered
  registered
  per share
  offering price
  registration fee
  Common Stock, $0.01 par value
  1,150,617
  (1)
  $
  0.20
  (2)
  $
  230,123
  (2)
  $
  10.00
  Common Stock, $0.01 par value
  340,000
  (3)
  $
  4.07
  $
  1,383,800
  $
  55.00
  Total
  1,490,617
  $
  1,613,923
  $
  65.00
  (1)
  Represents additional shares which may be sold upon the exercise of options and the issuance of stock awards which may
  hereafter be granted under the Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan, as amended (the "Plan"). The maximum number of shares which may be sold upon the exercise of options or issuance of
  stock awards granted under the Plan is subject to adjustment in accordance with certain anti-dilution and other provisions of
  the Plan. Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this
  Registration Statement covers, in addition to the number of shares stated above, an indeterminate number of shares which may
  be subject to grant or otherwise issuable upon the operation of any such anti-dilution and other provisions.
  (2)
  This calculation is made solely for the purpose of determining the registration fee pursuant to the provisions of Rule 457(c)
  and (h) under the Securities Act. The fee is calculated on the basis of the average of the high and low sale prices per share
  of the Common Stock on The Nasdaq Global Market as of a date (March 4, 2009) within five business days prior to filing this
  Registration Statement.
  (3)
  Represents shares of Common Stock reserved for issuance upon the exercise of inducement options (the "Inducement Grant")
  granted on June 2, 2008 to Dr. Georges Gemayel in connection with his employment.
  TABLE OF CONTENTS
  PART I
  PART II
  Item 3. Incorporation of Documents by Reference.
  Item 4. Description of Securities.
  Item 5. Interests of Named Experts and Counsel.
  Item 6. Indemnification of Directors and Officers.
  Item 7. Exemption from Registration Claimed.
  Item 8. Exhibits.
  Item 9. Undertakings.
  SIGNATURES
  INDEX OF EXHIBITS
  Ex-5.1 Opinion of Ropes & Gray LLP.
  Ex-23.2 Consent of Deloitte & Touche LLP.
  Ex-23.3 Consent of Ernst & Young LLP.
  Ex-99.3 Non-Qualified Stock Option Agreement
  Table of Contents
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  Information required by Part I to be contained in the Section 10(a) prospectus is omitted from this
  Registration Statement in accordance with Rule 428 under the
  Securities Act of 1933, as amended, and
  the Note to Part I of Form S-8.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference.
  The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  (1)
  The Registrant's Annual Report on Form 10-K for the fiscal year ended
  December 31, 2008 filed on March 11, 2009 (File No. 000-51711);
  (2)
  The Registrant's Current Reports on Form 8-K filed on January 6, 2009,
  January 26, 2009 and February 26, 2009 (File No. 000-51711); and
  (3)
  The description of the Registrant's Common Stock contained in the
  Registrant's Registration Statement on Form 8-A, filed with the
  Commission on January 11, 2006 (File No. 000-51711), including any
  amendment or report filed for the purpose of updating such
  description.
  All reports and other documents filed by the Registrant after the date hereof pursuant to Sections
  13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, prior to the filing of a
  post-effective amendment which indicates that all securities offered hereby have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference
  herein and to be part hereof from the date of filing of such reports and documents. Any statement
  contained in a document incorporated or deemed to be incorporated by reference herein shall be
  deemed to be modified or superseded for the purposes of this Registration Statement to the extent
  that a statement contained herein or in any other subsequently filed document which also is or is
  deemed to be
  incorporated by reference herein modifies or supersedes such statement. Any statement so modified
  or superseded shall not be deemed, except as so modified or superseded, to constitute a part of
  this Registration Statement.
  Table of Contents
  Item 4. Description of Securities.
  Not applicable.
  Item 5. Interests of Named Experts and Counsel.
  Not applicable.
  Item 6. Indemnification of Directors and Officers.
  Section 145 of the Delaware General Corporation Law ("DGCL") provides that a corporation may
  indemnify any person who was or is a party or is threatened to be made a party to any threatened,
  pending or completed action, suit or proceeding, whether civil, criminal or investigative (other
  than an action by or in the right of the corporation) by reason of the fact that he is or was a
  director, officer, employee or agent of the corporation, or is or was serving at the request of the
  corporation as a director, officer, employee or agent of another corporation, partnership, joint
  venture, trust or other enterprise, against expenses (including attorney's fees), judgments, fines
  and amounts paid in settlement actually and reasonably incurred by him in connection with such
  action, suit or proceeding if he acted in good faith and in a manner he reasonably believed to be
  in or not opposed to the best interests of the corporation, and, with respect to any criminal
  action or proceeding, had no reasonable cause to believe his conduct was unlawful. Section 145
  further provides that a corporation similarly may indemnify any such person serving in any such
  capacity who was or is a party or is threatened to be made a party to any threatened, pending or
  completed action or suit by or in the right of the corporation to procure a judgment in its favor,
  against expenses actually and reasonably incurred in connection with the defense or settlement of
  such action or suit if he acted in good faith and in a manner he reasonably believed to be in or
  not opposed to the best interests of the corporation and except that no indemnification shall be
  made in respect of any claim, issue or matter as to which such person shall have been adjudged to
  be liable to the corporation unless and only to the extent that the Delaware Court of Chancery or
  such other court in which such action or suit was brought shall determine upon application that,
  despite the adjudication of liability but in view of all the circumstances of the case, such person
  is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or
  such other court shall deem proper.
  Section 102(b)(7) of the DGCL permits a corporation to include in its certificate of
  incorporation a provision eliminating or limiting the personal liability of a director to the
  corporation or its stockholders for monetary damages for breach of fiduciary duty as a director,
  provided that such provision shall not eliminate or limit the liability of a director (i) for any
  breach of the director's duty of loyalty to the corporation or its stockholders, (ii) for acts or
  omissions not in good faith or which involve intentional misconduct or a knowing violation of law,
  (iii) under Section 174 of the DGCL (relating to unlawful payment of dividends and unlawful stock
  purchase and redemption) or (iv) for any transaction from which the director derived an improper
  personal benefit.
  The Registrant's restated certificate of incorporation and restated bylaws provide that each
  person who was or is made a party or is threatened to be made a party to any action, suit or
  proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he
  or she is or was one of the Registrant's directors or officers or is or was serving at the
  Registrant's request as a director, officer, employee or agent of another corporation, or of a
  partnership, joint venture, trust or other enterprise, shall be indemnified by the Registrant to
  the fullest extent authorized by the DGCL against all expense, liability and loss (including
  attorneys' fees, judgments, fines or penalties and amounts paid in settlement) reasonably incurred
  in connection with legal proceedings. A director or officer will not receive indemnification if he
  or she is found not to have acted in good faith and in a manner he or she reasonably believed to be
  in, or not opposed to, the Registrant's best interest.
  The Registrant carries insurance policies insuring its directors and officers against certain
  liabilities that they may incur in their capacity as directors and officers. In addition, the
  Registrant has entered into indemnification agreements with its directors and executive officers.
  These agreements contain presumptions and procedures
  designed to ensure that the indemnification and advancement rights granted to each indemnitee in
  these agreements will be provided on a timely basis. Each agreement provides that the Registrant's
  obligations under the agreement
  will continue during the time the indemnitee serves the Registrant
  and continues thereafter so long as the indemnitee is subject to any possible proceeding by reason
  of the indemnitee's service to the Registrant.
  Table of Contents
  Item 7. Exemption from Registration Claimed.
  Not Applicable.
  Item 8. Exhibits.
  Exhibit
  Number
  Description
  (4.1
  )
  Restated Certificate of Incorporation of the Registrant. Filed as
  Exhibit 3.1 to the Registrant's Annual Report on Form 10-K for the
  fiscal year ended December 31, 2006, as amended (File No.
  000-51711) and incorporated herein by reference.
  (4.2
  )
  Restated By-laws of the Registrant. Filed as Exhibit 3.4 to the
  Registrant's Registration Statement on Form S-1, as amended (File
  No. 333-129037) and incorporated herein by reference.
  (4.3
  )
  Form of Common Stock Certificate. Filed as Exhibit 4.1 to the
  Registrant's Registration Statement on Form S-1, as amended (File
  No. 333-129037) and incorporated herein by reference.
  (4.4
  )
  Amended and Restated Investor Rights Agreement, dated as of May 21,
  2004. Filed as Exhibit 4.3 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (4.5
  )
  Form of Common Stock Warrant to Cystic Fibrosis Foundation
  Therapeutics, Inc. Filed as Exhibit 4.9 to the Registrant's
  Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.
  (4.6
  )
  Form of Common Stock Warrant to SG Cowen & Co. Filed as Exhibit
  4.11 to the Registrant's Registration Statement on Form S-1, as
  amended (File No. 333-129037) and incorporated herein by reference.
  (4.7
  )
  Form of Series B Preferred Stock Warrant, as amended, together with
  a schedule of warrant holders. Filed as Exhibit 4.12 to the
  Registrant's Registration Statement on Form S-1, as amended (File
  No. 333-129037) and incorporated herein by reference.
  (4.8
  )
  Form of Series C Preferred Stock Warrant, together with a schedule
  of warrant holders. Filed as Exhibit 4.13 to the Registrant's
  Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.
  (4.9
  )
  Common Stock Purchase Agreement, dated as of December 19, 2006,
  between the Registrant and Genentech, Inc. Filed as Exhibit 10.1 to
  the Registrant's Form 8-K filed with the Securities and Exchange
  Commission on March 1, 2007 (File No. 000-51711) and incorporated
  herein by reference.
  (4.10
  )
  Registration Rights Agreement, dated as of February 27, 2007,
  between the Registrant and Genentech, Inc. Filed as Exhibit 10.2 to
  the Registrant's Form 8-K filed with the Securities and Exchange
  Commission on March 1, 2007 (File No. 000-51711) and incorporated
  herein by reference.
  (4.11
  )
  Form of Common Stock Warrant issued to Adage Capital Partners, L.P.
  Filed as Exhibit 4.5 to the Registrant's Registration Statement on
  Form S-3 (File No. 333-141414) and incorporated herein by
  reference.
  Table of Contents
  Exhibit
  Number
  Description
  (5.1
  )
  Opinion of Ropes & Gray LLP. (Filed herewith).
  (23.1
  )
  Consent of Ropes & Gray LLP. (Contained in Exhibit 5.1).
  (23.2
  )
  Consent of Deloitte & Touche LLP. (Filed herewith).
  (23.3
  )
  Consent of Ernst & Young LLP. (Filed herewith).
  (24.1
  )
  Power of Attorney to file future amendments. (Set forth on the signature page of this Registration Statement).
  (99.1
  )
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee,
  Director and Consultant Stock Plan, as amended. Filed as Exhibit
  10.4 to the Registrant's Annual Report on Form 10-K for the fiscal
  year ended December 31, 2006, as amended (File No. 000-51711) and
  incorporated herein by reference.
  (99.2
  )
  Offer Agreement between the Registrant and Georges Gemayel, Ph.D.,
  dated May 21, 2008. Filed as Exhibit 10.1 to the Registrant's Form
  8-K filed with the Securities and Exchange Commission on May 27,
  2008 (File No. 000-51711) and incorporated herein by reference.
  (99.3
  )
  Altus Pharmaceuticals, Inc. Non-Qualified Stock Option Agreement, dated June 2, 2008. (Filed herewith).
  Item 9. Undertakings.
  (a)  The undersigned registrant hereby undertakes:
  1. To file, during any period in which offers or sales are being made, a post-effective amendment
  to this registration statement:
  (i) To include any prospectus required by section 10(a)(3) of the Securities Act of 1933;
  (ii) To reflect in the prospectus any facts or events arising after the effective date of the
  registration statement (or the most recent post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the information set forth in the registration
  statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
  (if the total dollar value of securities offered would not exceed that which was registered) and
  any deviation from the low or high end of the estimated maximum offering range may be reflected in
  the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
  changes in volume and price represent no more than 20 percent change in the maximum aggregate
  offering price set forth in the "Calculation of Registration Fee" table in the effective
  registration statement.
  (iii) To include any material information with respect to the plan of distribution not previously
  disclosed in the registration statement or any material change to such information in the
  registration statement.
  Provided, however
  , That paragraphs (a)(1)(i) and (a)(1)(ii) above do not apply if the information
  required to be included in a post-effective amendment by those paragraphs is contained in reports
  filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d)
  of the Securities Exchange Act of 1934 that are incorporated by reference in the registration
  statement.
  2. That, for the purpose of determining any liability under the Securities Act of 1933, each such
  post-effective amendment shall be deemed to be a new registration statement relating to the
  securities offered therein, and the offering of such securities at that time shall be deemed to be
  the initial bona fide offering thereof.
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  3. To remove from registration by means of a post-effective amendment any of the securities being
  registered which remain unsold at the termination of the offering.
  (b)  The undersigned registrant hereby undertakes that, for purposes of determining any liability under
  the Securities Act of 1933, each filing of the registrant's annual report pursuant to section 13(a)
  or section 15(d) of the Securities Exchange Act of 1934 that is incorporated by reference in the
  registration statement shall be deemed to be a new registration statement relating to the
  securities offered therein, and the offering of such securities at that time shall be deemed to be
  the initial bona fide offering thereof.
  (c)  Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the registrant pursuant to the
  foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the
  Commission such indemnification is against public policy as expressed in the Act and is, therefore,
  unenforceable. In the event that a claim for indemnification against such liabilities (other than
  the payment by the registrant of expenses incurred or paid by a director, officer or controlling
  person of the registrant in the successful defense of any action, suit or proceeding) is asserted
  by such director, officer or controlling person in connection with the securities being registered,
  the registrant will, unless in the opinion of its counsel the matter has been settled by
  controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Act and will be governed by the
  final adjudication of such issue.
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  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has
  reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
  duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
  duly authorized, in Waltham, Massachusetts on March 10, 2009.
  ALTUS PHARMACEUTICALS INC.
  By
  /s/ GEORGES GEMAYEL
  Georges Gemayel, Ph.D.
  Chief Executive Officer
  Power Of Attorney
  Each person whose signature appears below constitutes and appoints Georges Gemayel, Ph. D. and
  Thomas J. Phair, Jr., and each of them singly, his true and lawful attorneys-in-fact and agents,
  with full power of substitution and resubstitution in each of them singly, for him and in his name,
  place and stead, and in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement on Form S-8 of Altus Pharmaceuticals
  Inc., and to file the same, with all exhibits thereto and other documents in connection therewith,
  with the Securities and Exchange Commission, granting to the attorneys-in-fact and agents, and each
  of them, full power and authority to do and perform each and every act and thing requisite or
  necessary to be done in or about the premises, as full to all intents and purposes as he might or
  could do in person, hereby ratifying and confirming all that the attorneys-in-fact and agents or
  any of each of them or their substitute may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been
  signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ GEORGES GEMAYEL
  President, Chief Executive Officer and
  March 10, 2009
  Georges Gemayel, Ph.D.
  Director
  (principal executive officer)
  /s/ JONATHAN I. LIEBER
  Senior Vice President, Chief Financial Officer and
  March 10, 2009
  Jonathan I. Lieber
  Treasurer
  (principal
  financial and accounting officer)
  /s/ DAVID D. PENDERGAST
  Chairman of the Board
  March 10, 2009
  David D. Pendergast, Ph.D.
  /s/ MANUEL A. NAVIA
  Director
  March 10, 2009
  Manuel A. Navia, Ph.D.
  /s/ HARRY H. PENNER, JR.
  Director
  March 10, 2009
  Harry H. Penner, Jr.
  /s/ JOHN P. RICHARD
  Director
  March 10, 2009
  John P. Richard
  /s/ JONATHAN D. ROOT
  Director
  March 10, 2009
  Jonathan D. Root, M.D.
  /s/ MICHAEL S. WYZGA
  Director
  March 10, 2009
  Michael S. Wyzga
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  INDEX OF EXHIBITS
  Exhibit
  Number
  Description
  (4.1)
  Restated Certificate of Incorporation of the Registrant. Filed as
  Exhibit 3.1 to the Registrant's Annual Report on Form 10-K for the
  fiscal year ended December 31, 2006, as amended (File No.
  000-51711) and incorporated herein by reference.
  (4.2)
  Restated By-laws of the Registrant. Filed as Exhibit 3.4 to the
  Registrant's Registration Statement on Form S-1, as amended (File
  No. 333-129037) and incorporated herein by reference.
  (4.3)
  Form of Common Stock Certificate. Filed as Exhibit 4.1 to the
  Registrant's Registration Statement on Form S-1, as amended (File
  No. 333-129037) and incorporated herein by reference.
  (4.4)
  Amended and Restated Investor Rights Agreement, dated as of May 21,
  2004. Filed as Exhibit 4.3 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (4.5)
  Form of Common Stock Warrant to Cystic Fibrosis Foundation
  Therapeutics, Inc. Filed as Exhibit 4.9 to the Registrant's
  Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.
  (4.6)
  Form of Common Stock Warrant to SG Cowen & Co. Filed as Exhibit
  4.11 to the Registrant's Registration Statement on Form S-1, as
  amended (File No. 333-129037) and incorporated herein by reference.
  (4.7)
  Form of Series B Preferred Stock Warrant, as amended, together with
  a schedule of warrant holders. Filed as Exhibit 4.12 to the
  Registrant's Registration Statement on Form S-1, as amended (File
  No. 333-129037) and incorporated herein by reference.
  (4.8)
  Form of Series C Preferred Stock Warrant, together with a schedule
  of warrant holders. Filed as Exhibit 4.13 to the Registrant's
  Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.
  (4.9)
  Common Stock Purchase Agreement, dated as of December 19, 2006,
  between the Registrant and Genentech, Inc. Filed as Exhibit 10.1 to
  the Registrant's Form 8-K filed with the Securities and Exchange
  Commission on March 1, 2007 (File No. 000-51711) and incorporated
  herein by reference.
  (4.10)
  Registration Rights Agreement, dated as of February 27, 2007,
  between the Registrant and Genentech, Inc. Filed as Exhibit 10.2 to
  the Registrant's Form 8-K filed with the Securities and Exchange
  Commission on March 1, 2007 (File No. 000-51711) and incorporated
  herein by reference.
  (4.11)
  Form of Common Stock Warrant issued to Adage Capital Partners, L.P.
  Filed as Exhibit 4.5 to the Registrant's Registration Statement on
  Form S-3 (File No. 333-141414) and incorporated herein by
  reference.
  (5.1)
  Opinion of Ropes & Gray LLP. (Filed herewith).
  (23.1)
  Consent of Ropes & Gray LLP.
  (Contained in Exhibit 5.1).
  (23.2)
  Consent of Deloitte & Touche LLP. (Filed herewith).
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  Exhibit
  Number
  Description
  (23.3)
  Consent of Ernst & Young LLP. (Filed herewith).
  (24.1)
  Power of Attorney to file future amendments. (Set forth on the
  signature page of this Registration Statement).
  (99.1)
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee,
  Director and Consultant Stock Plan, as amended. Filed as Exhibit
  10.4 to the Registrant's Annual Report on Form 10-K for the fiscal
  year ended December 31, 2006, as amended (File No. 000-51711) and
  incorporated herein by reference.
  (99.2)
  Offer Agreement between the Registrant and Georges Gemayel, Ph.D.,
  dated May 21, 2008. Filed as Exhibit 10.1 to the Registrant's Form
  8-K filed with the Securities and Exchange Commission on May 27,
  2008 (File No. 000-51711) and incorporated herein by reference.
  (99.3)
  Altus Pharmaceuticals, Inc. Non-Qualified Stock Option Agreement,
  dated June 2, 2008. (Filed herewith).