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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">As filed with the Securities and Exchange Commission on January&nbsp;29, 2008<BR>
  Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>REGISTRATION STATEMENT<BR>
  Under<BR>
  The Securities Act of 1933</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>VANDA PHARMACEUTICALS INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B><BR>
  (State or other jurisdiction of <BR>
  incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>03-0491827</B><BR>
  (IRS Employer<BR>
  Identification No.)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>9605 Medical Center Drive<BR>
  Suite&nbsp;300<BR>
  Rockville, Maryland 20850</B><BR>
  (Address of principal executive offices) (Zip Code)<BR>
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>VANDA PHARMACEUTICALS INC. 2006 EQUITY INCENTIVE PLAN</B><BR>
  (Full title of the Plan)<BR>
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Mihael H. Polymeropoulos, M.D.<BR>
  Chief Executive Officer<BR>
  Vanda Pharmaceuticals Inc.<BR>
  9605 Medical Center Drive<BR>
  Suite&nbsp;300<BR>
  Rockville, Maryland 20850</B><BR>
  (Name and address of agent for service)<BR>
  <B>(240)&nbsp;599-4500</B><BR>
  (Name, address and telephone number, including area code, of agent for service)<BR>
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CALCULATION OF REGISTRATION FEE</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Proposed</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Proposed Maximum</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Amount to be</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Maximum Offering</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Aggregate Offering</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Amount of Registration</B></TD>
      <TD>&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center"><B>Title of Securities to be Registered</B></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Registered(1)</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Price per Share(2)</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Price(2)</B></TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2"><B>Fee</B></TD>
      <TD>&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Stock Options and Common Stock,
  $0.001 par value</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD colspan="3" align="center" style="border-top: 2px solid #000000">1,066,109&nbsp;shares</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD colspan="2" align="center" style="border-top: 2px solid #000000">$4.62</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD colspan="2" align="center" style="border-top: 2px solid #000000">$4,925,423.58</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD colspan="2" align="center" style="border-top: 2px solid #000000">$193.57</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="23" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV style="margin-top: 3pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>This Registration Statement shall also cover any additional shares of Common Stock
  which become issuable under the 2006 Equity Incentive Plan by reason of any stock dividend,
  stock split, recapitalization or other similar transaction effected without the receipt of
  consideration which results in an increase in the number of the outstanding shares of
  Common Stock of Vanda Pharmaceuticals Inc.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of calculating the amount of the registration fee
  pursuant to Rule 457(c) and (h)(1) under the Securities Act. The offering price per share
  and aggregate offering price for the unissued stock options and shares of common stock are
  based upon the average of the high and low prices of the Registrant&#146;s common stock as
  reported on The Nasdaq Global Market on January&nbsp;28, 2008.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
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  	<TD width="3%"></TD>
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  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART II Information Required in the Registration Statement</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#001">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#002">POWER OF ATTORNEY</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003">EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b68333vpexv5w1.htm">EX-5.1 Consent of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b68333vpexv23w2.htm">EX-23.2 Consent of PricewaterhouseCoopers LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <!-- link1 "PART II Information Required in the Registration Statement" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Information Required in the Registration Statement</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="4%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="94%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Item&nbsp;3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><U>Incorporation of Documents by Reference</U></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Vanda Pharmaceuticals Inc. (the &#147;Registrant&#148;) hereby incorporates by reference into this
  Registration Statement the following documents previously filed with the Securities and Exchange
  Commission (the &#147;SEC&#148;):
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The Registrant&#146;s Annual Report on Form 10-K for its fiscal year ended December
  31, 2006, filed on March&nbsp;16, 2007 in accordance with the Securities Exchange Act of
  1934 (the &#147;1934 Act&#148;);</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>(1)&nbsp;The Registrant&#146;s Quarterly Reports on Form 10-Q for the fiscal quarters
  ended March&nbsp;31, 2007, June&nbsp;30, 2007 and September&nbsp;30, 2007 filed on May&nbsp;8, 2007, August
  8, 2007 and November&nbsp;8, 2007, respectively, in accordance with the 1934 Act;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>(2)&nbsp;The Registrant&#146;s Current Reports on Form 8-K filed with the SEC on April&nbsp;25.
  2007, May&nbsp;1, 2007, June 5. 2007, July&nbsp;27, 2007, August 2. 2007, September&nbsp;27, 2007,
  October&nbsp;29, 2007, October&nbsp;31, 2007, November&nbsp;2, 2007, November&nbsp;8, 2007 and December
  13, 2007.</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="4%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The description of the Registrant&#146;s outstanding Common Stock contained in the
  Registrant&#146;s Registration Statement No.&nbsp;000-51863 on Form 8-A filed with the SEC on
  March&nbsp;28, 2006, pursuant to Section&nbsp;12 of the 1934 Act, including any amendment or
  report filed for the purpose of updating such description.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and definitive proxy or information statements filed pursuant to Section&nbsp;13(a),
  13(c), 14 or 15(d) of the 1934 Act after the date of this Registration Statement and prior to the
  filing of a post-effective amendment which indicates that all securities offered hereby have been
  sold or which deregisters all securities then remaining unsold shall be deemed to be incorporated
  by reference into this Registration Statement and to be a part hereof from the date of filing of
  such documents. Any statement contained in a document incorporated or deemed to be incorporated by
  reference herein shall be deemed to be modified or superseded for purposes of this Registration
  Statement to the extent that a statement contained herein, or in any other subsequently filed
  document that also is or is deemed to be incorporated by reference herein, modifies or supersedes
  such statement. Any such statement so modified or superseded shall not be deemed, except as so
  modified or superseded, to constitute a part of this Registration Statement.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="4%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="94%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Item&nbsp;4.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><U>Description of Securities</U></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Not Applicable.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Item&nbsp;5.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><U>Interests of Named Experts and Counsel</U></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Not Applicable.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Item&nbsp;6.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><U>Indemnification of Directors and Officers</U></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the Delaware General Corporation Law authorizes a court to award or a
  corporation&#146;s Board of Directors to grant indemnification to directors and officers in terms
  sufficiently broad to permit such indemnification under certain circumstances for liabilities
  (including reimbursement for expenses incurred) arising under the 1933 Act. The Registrant&#146;s
  Bylaws provide for mandatory indemnification of its directors and officers to the maximum extent
  permitted by the Delaware General Corporation Law. The Registrant&#146;s Certificate of Incorporation
  provides that, pursuant to Delaware law, its directors shall not be liable for monetary damages for
  breach of their fiduciary duty as directors to the Registrant and its stockholders. This provision
  in the Certificate of Incorporation does not eliminate the fiduciary duty of the directors, and, in
  appropriate circumstances, equitable remedies such as injunctive or other forms of non-monetary
  relief will remain available under Delaware law. In addition, each director will continue to be
  subject to liability for breach of the director&#146;s duty of loyalty to the
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-1<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Registrant for acts or omissions not in good faith or involving intentional misconduct, for
  knowing violations of law, for actions leading to improper personal benefit to the director and for
  payment of dividends or approval of stock repurchases or redemptions that are unlawful under
  Delaware law. The provision also does not affect a director&#146;s responsibilities under any other
  law, such as the federal securities laws or state or federal environmental laws. The Registrant
  has entered into Indemnification Agreements with its directors and officers. The Indemnification
  Agreements provide the Registrant&#146;s directors and officers with further indemnification to the
  maximum extent permitted by the Delaware General Corporation Law.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="4%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="94%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Item&nbsp;7.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><U>Exemption from Registration Claimed</U></TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Not Applicable.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Item&nbsp;8.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><U>Exhibits</U></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="10%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Reference is made to Vanda Pharmaceuticals Inc.&#146;s Registration Statement No.
  000-51863 on Form&nbsp;8-A, together with all amendments and exhibits thereto, which
  is incorporated herein by reference under Item&nbsp;3(c) of this Registration
  Statement</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion and consent of Gunderson Dettmer Stough Villeneuve Franklin &#038; Hachigian
  LLP</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Gunderson Dettmer Stough Villeneuve Franklin &#038; Hachigian, LLP
  (included in Exhibit&nbsp;5)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting
  Firm</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney: Reference is made to page II-4 of this Registration Statement</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="4%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="94%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Item&nbsp;9.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><U>Undertakings</U></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A.&nbsp;The undersigned Registrant hereby undertakes: (1)&nbsp;to file, during any period in which
  offers or sales are being made, a post-effective amendment to this Registration Statement (i)&nbsp;to
  include any prospectus required by Section&nbsp;10(a)(3) of the 1933 Act, (ii)&nbsp;to reflect in the
  prospectus any facts or events arising after the effective date of this Registration Statement (or
  the most recent post-effective amendment thereof) which, individually or in the aggregate,
  represent a fundamental change in the information set forth in this Registration Statement and
  (iii)&nbsp;to include any material information with respect to the plan of distribution not previously
  disclosed in this Registration Statement or any material change to such information in this
  Registration Statement; <U>provided</U>, however, that clauses (1)(i) and (1)(ii) shall not apply
  if the information required to be included in a post-effective amendment by those paragraphs is
  contained in reports filed with or furnished to the SEC by the Registrant pursuant to Section&nbsp;13 or
  Section 15(d) of the 1934 Act that are incorporated by reference in this Registration Statement;
  (2)&nbsp;that for the purpose of determining any liability under the 1933 Act each such post-effective
  amendment shall be deemed to be a new registration statement relating to the securities offered
  therein and the offering of such securities at that time shall be deemed to be the initial bona
  fide offering thereof and (3)&nbsp;to remove from registration by means of a post-effective amendment
  any of the securities being registered which remain unsold at the termination of the Registrant&#146;s
  2006 Equity Incentive Plan.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B.&nbsp;The undersigned Registrant hereby undertakes that, for purposes of determining any
  liability under the 1933 Act, each filing of the Registrant&#146;s annual report pursuant to Section
  13(a) or Section 15(d) of the 1934 Act that is incorporated by reference in this Registration
  Statement shall be deemed to be a new registration statement relating to the securities offered
  therein, and the offering of such securities at that time shall be deemed to be the initial bona
  fide offering thereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C.&nbsp;Insofar as indemnification for liabilities arising under the 1933 Act may be permitted to
  directors, officers or controlling persons of the Registrant pursuant to the indemnification
  provisions summarized in Item&nbsp;6 or otherwise, the Registrant has been advised that, in the opinion
  of the SEC, such indemnification is against public policy as expressed in the 1933 Act, and is,
  therefore, unenforceable. In the event that a claim for indemnification
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-2<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense of
  any action, suit or proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the Registrant will, unless in the opinion of its
  counsel the matter has been settled by controlling precedent, submit to a court of appropriate
  jurisdiction the question whether such indemnification by it is against public policy as expressed
  in the 1933 Act and will be governed by the final adjudication of such issue.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-3<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
  the undersigned, thereunto duly authorized, in the City of Rockville, State of Maryland on this
  29<SUP style="font-size: 85%; vertical-align: text-top">th</SUP> day of January, 2008.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left"><B>VANDA PHARMACEUTICALS INC.</B><BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Mihael H. Polymeropoulos
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Mihael H. Polymeropoulos, M.D.&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <!-- link1 "POWER OF ATTORNEY" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>POWER OF ATTORNEY</B></U>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>KNOW ALL PERSONS BY THESE PRESENTS:</B>
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The undersigned officers and directors of Vanda Pharmaceuticals Inc. hereby constitute Mihael
  H. Polymeropoulos, M.D., and Steven A. Shallcross, and each of them singly, with full power of
  substitution, our true and lawful attorneys-in-fact and agents to take any actions to enable Vanda
  Pharmaceuticals Inc. to comply with the Securities Act, and any rules, regulations and requirements
  of the Securities and Exchange Commission, in connection with this registration statement,
  including the power and authority to sign for us in our names in the capacities indicated below any
  and all amendments (including post-effective amendments) to this registration statement and any
  other registration statement filed pursuant to the provisions of Rule&nbsp;462 under the Securities Act
  and the power to file the same, with all exhibits thereto, and all other documents in connection
  therewith, with the Securities and Exchange Commission, granting unto each said attorney-in-fact
  and agents full power and authority to perform each and every act in person, hereby ratifying and
  confirming all that said attorneys-in-fact and agents or either of them or their or his substitute
  or substitutes may lawfully do or cause to be done by virtue hereof. This Power of Attorney may be
  signed in several counterparts.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>IN WITNESS WHEREOF</B>, each of the undersigned has executed this Power of Attorney as of the date
  indicated.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration
  Statement has been signed below by the following persons in the capacities and on the dates
  indicated.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="14%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000; border-top: 1px solid #000000"><B>Name</B></TD>
      <TD style="border-bottom: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000; border-top: 1px solid #000000"><B>Title</B></TD>
      <TD style="border-bottom: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000; border-top: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Mihael H. Polymeropoulos
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  <DIV align="center">Mihael H. Polymeropoulos, M.D.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  President and Chief Executive
  Officer and Director<BR>(principal
  executive officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 29, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Steven A. Shallcross
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  <DIV align="center">Steven A. Shallcross</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Senior Vice President, and Chief
  Financial Officer and<BR>Treasurer
  (principal financial and
  accounting officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 29, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Argeris N. Karabelas
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  <DIV align="center">Argeris N. Karabelas, Ph.D.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director and Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 29, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Brian K. Halak
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  <DIV align="center">Brian K. Halak, Ph.D.</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 29, 2008</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-4<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="14%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000; border-top: 1px solid #000000"><B>Name</B></TD>
      <TD style="border-bottom: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000; border-top: 1px solid #000000"><B>Title</B></TD>
      <TD style="border-bottom: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000; border-top: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ H. Thomas Watkins
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  <DIV align="center">H. Thomas Watkins</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 29, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ David Ramsay
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  <DIV align="center">David Ramsay</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 29, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Howard H. Pien
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  <DIV align="center">Howard H. Pien</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 29, 2008</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="left" nowrap valign="top">/s/ Richard W. Dugan
  <DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
  <DIV align="center">Richard W. Dugan</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">January 29, 2008</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-5<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXHIBIT INDEX</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="10%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Reference is made to Vanda Pharmaceuticals Inc.&#146;s Registration Statement No.
  000-51863 on Form&nbsp;8-A, together with all amendments and exhibits thereto, which
  is incorporated herein by reference under Item&nbsp;3(c) of this Registration
  Statement</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion and consent of Gunderson Dettmer Stough Villeneuve Franklin &#038; Hachigian,
  LLP</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Gunderson Dettmer Stough Villeneuve Franklin &#038; Hachigian, LLP.
  (included in Exhibit&nbsp;5)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting
  Firm</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney: Reference is made to page II-4 of this Registration Statement</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  </BODY>
  </HTML>
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text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on January 29, 2008
  Registration No. 333-
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  Under
  The Securities Act of 1933
  VANDA PHARMACEUTICALS INC.
  (Exact name of registrant as specified in its charter)
  Delaware
  (State or other jurisdiction of
  incorporation or organization)
  03-0491827
  (IRS Employer
  Identification No.)
  9605 Medical Center Drive
  Suite 300
  Rockville, Maryland 20850
  (Address of principal executive offices) (Zip Code)
  VANDA PHARMACEUTICALS INC. 2006 EQUITY INCENTIVE PLAN
  (Full title of the Plan)
  Mihael H. Polymeropoulos, M.D.
  Chief Executive Officer
  Vanda Pharmaceuticals Inc.
  9605 Medical Center Drive
  Suite 300
  Rockville, Maryland 20850
  (Name and address of agent for service)
  (240) 599-4500
  (Name, address and telephone number, including area code, of agent for service)
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed Maximum
  Amount to be
  Maximum Offering
  Aggregate Offering
  Amount of Registration
  Title of Securities to be Registered
  Registered(1)
  Price per Share(2)
  Price(2)
  Fee
  Stock Options and Common Stock,
  $0.001 par value
  1,066,109 shares
  $4.62
  $4,925,423.58
  $193.57
  (1)
  This Registration Statement shall also cover any additional shares of Common Stock
  which become issuable under the 2006 Equity Incentive Plan by reason of any stock dividend,
  stock split, recapitalization or other similar transaction effected without the receipt of
  consideration which results in an increase in the number of the outstanding shares of
  Common Stock of Vanda Pharmaceuticals Inc.
  (2)
  Estimated solely for the purpose of calculating the amount of the registration fee
  pursuant to Rule 457(c) and (h)(1) under the Securities Act. The offering price per share
  and aggregate offering price for the unissued stock options and shares of common stock are
  based upon the average of the high and low prices of the Registrant's common stock as
  reported on The Nasdaq Global Market on January 28, 2008.
  TABLE OF CONTENTS
  PART II Information Required in the Registration Statement
  SIGNATURES
  POWER OF ATTORNEY
  EXHIBIT INDEX
  EX-5.1 Consent of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP
  EX-23.2 Consent of PricewaterhouseCoopers LLP
  Table of Contents
  PART II
  Information Required in the Registration Statement
  Item 3
  Incorporation of Documents by Reference
  Vanda Pharmaceuticals Inc. (the "Registrant") hereby incorporates by reference into this
  Registration Statement the following documents previously filed with the Securities and Exchange
  Commission (the "SEC"):
  (a)
  The Registrant's Annual Report on Form 10-K for its fiscal year ended December
  31, 2006, filed on March 16, 2007 in accordance with the Securities Exchange Act of
  1934 (the "1934 Act");
  (b)
  (1) The Registrant's Quarterly Reports on Form 10-Q for the fiscal quarters
  ended March 31, 2007, June 30, 2007 and September 30, 2007 filed on May 8, 2007, August
  8, 2007 and November 8, 2007, respectively, in accordance with the 1934 Act;
  (2) The Registrant's Current Reports on Form 8-K filed with the SEC on April 25.
  2007, May 1, 2007, June 5. 2007, July 27, 2007, August 2. 2007, September 27, 2007,
  October 29, 2007, October 31, 2007, November 2, 2007, November 8, 2007 and December
  13, 2007.
  (c)
  The description of the Registrant's outstanding Common Stock contained in the
  Registrant's Registration Statement No. 000-51863 on Form 8-A filed with the SEC on
  March 28, 2006, pursuant to Section 12 of the 1934 Act, including any amendment or
  report filed for the purpose of updating such description.
  All reports and definitive proxy or information statements filed pursuant to Section 13(a),
  13(c), 14 or 15(d) of the 1934 Act after the date of this Registration Statement and prior to the
  filing of a post-effective amendment which indicates that all securities offered hereby have been
  sold or which deregisters all securities then remaining unsold shall be deemed to be incorporated
  by reference into this Registration Statement and to be a part hereof from the date of filing of
  such documents. Any statement contained in a document incorporated or deemed to be incorporated by
  reference herein shall be deemed to be modified or superseded for purposes of this Registration
  Statement to the extent that a statement contained herein, or in any other subsequently filed
  document that also is or is deemed to be incorporated by reference herein, modifies or supersedes
  such statement. Any such statement so modified or superseded shall not be deemed, except as so
  modified or superseded, to constitute a part of this Registration Statement.
  Item 4.
  Description of Securities
  Not Applicable.
  Item 5.
  Interests of Named Experts and Counsel
  Not Applicable.
  Item 6.
  Indemnification of Directors and Officers
  Section 145 of the Delaware General Corporation Law authorizes a court to award or a
  corporation's Board of Directors to grant indemnification to directors and officers in terms
  sufficiently broad to permit such indemnification under certain circumstances for liabilities
  (including reimbursement for expenses incurred) arising under the 1933 Act. The Registrant's
  Bylaws provide for mandatory indemnification of its directors and officers to the maximum extent
  permitted by the Delaware General Corporation Law. The Registrant's Certificate of Incorporation
  provides that, pursuant to Delaware law, its directors shall not be liable for monetary damages for
  breach of their fiduciary duty as directors to the Registrant and its stockholders. This provision
  in the Certificate of Incorporation does not eliminate the fiduciary duty of the directors, and, in
  appropriate circumstances, equitable remedies such as injunctive or other forms of non-monetary
  relief will remain available under Delaware law. In addition, each director will continue to be
  subject to liability for breach of the director's duty of loyalty to the
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  Registrant for acts or omissions not in good faith or involving intentional misconduct, for
  knowing violations of law, for actions leading to improper personal benefit to the director and for
  payment of dividends or approval of stock repurchases or redemptions that are unlawful under
  Delaware law. The provision also does not affect a director's responsibilities under any other
  law, such as the federal securities laws or state or federal environmental laws. The Registrant
  has entered into Indemnification Agreements with its directors and officers. The Indemnification
  Agreements provide the Registrant's directors and officers with further indemnification to the
  maximum extent permitted by the Delaware General Corporation Law.
  Item 7.
  Exemption from Registration Claimed
  Not Applicable.
  Item 8.
  Exhibits
  Exhibit Number
  Exhibit
  4.1
  Reference is made to Vanda Pharmaceuticals Inc.'s Registration Statement No.
  000-51863 on Form 8-A, together with all amendments and exhibits thereto, which
  is incorporated herein by reference under Item 3(c) of this Registration
  Statement
  5.1
  Opinion and consent of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian
  LLP
  23.1
  Consent of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP
  (included in Exhibit 5)
  23.2
  Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting
  Firm
  24.1
  Power of Attorney: Reference is made to page II-4 of this Registration Statement
  Item 9.
  Undertakings
  A. The undersigned Registrant hereby undertakes: (1) to file, during any period in which
  offers or sales are being made, a post-effective amendment to this Registration Statement (i) to
  include any prospectus required by Section 10(a)(3) of the 1933 Act, (ii) to reflect in the
  prospectus any facts or events arising after the effective date of this Registration Statement (or
  the most recent post-effective amendment thereof) which, individually or in the aggregate,
  represent a fundamental change in the information set forth in this Registration Statement and
  (iii) to include any material information with respect to the plan of distribution not previously
  disclosed in this Registration Statement or any material change to such information in this
  Registration Statement;
  provided
  , however, that clauses (1)(i) and (1)(ii) shall not apply
  if the information required to be included in a post-effective amendment by those paragraphs is
  contained in reports filed with or furnished to the SEC by the Registrant pursuant to Section 13 or
  Section 15(d) of the 1934 Act that are incorporated by reference in this Registration Statement;
  (2) that for the purpose of determining any liability under the 1933 Act each such post-effective
  amendment shall be deemed to be a new registration statement relating to the securities offered
  therein and the offering of such securities at that time shall be deemed to be the initial bona
  fide offering thereof and (3) to remove from registration by means of a post-effective amendment
  any of the securities being registered which remain unsold at the termination of the Registrant's
  2006 Equity Incentive Plan.
  B. The undersigned Registrant hereby undertakes that, for purposes of determining any
  liability under the 1933 Act, each filing of the Registrant's annual report pursuant to Section
  13(a) or Section 15(d) of the 1934 Act that is incorporated by reference in this Registration
  Statement shall be deemed to be a new registration statement relating to the securities offered
  therein, and the offering of such securities at that time shall be deemed to be the initial bona
  fide offering thereof.
  C. Insofar as indemnification for liabilities arising under the 1933 Act may be permitted to
  directors, officers or controlling persons of the Registrant pursuant to the indemnification
  provisions summarized in Item 6 or otherwise, the Registrant has been advised that, in the opinion
  of the SEC, such indemnification is against public policy as expressed in the 1933 Act, and is,
  therefore, unenforceable. In the event that a claim for indemnification
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  against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense of
  any action, suit or proceeding) is asserted by such director, officer or controlling person in
  connection with the securities being registered, the Registrant will, unless in the opinion of its
  counsel the matter has been settled by controlling precedent, submit to a court of appropriate
  jurisdiction the question whether such indemnification by it is against public policy as expressed
  in the 1933 Act and will be governed by the final adjudication of such issue.
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  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
  certifies that it has reasonable grounds to believe that it meets all of the requirements for
  filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
  the undersigned, thereunto duly authorized, in the City of Rockville, State of Maryland on this
  29
  th
  day of January, 2008.
  VANDA PHARMACEUTICALS INC.
  By:
  /s/ Mihael H. Polymeropoulos
  Mihael H. Polymeropoulos, M.D.
  Chief Executive Officer
  POWER OF ATTORNEY
  KNOW ALL PERSONS BY THESE PRESENTS:
  The undersigned officers and directors of Vanda Pharmaceuticals Inc. hereby constitute Mihael
  H. Polymeropoulos, M.D., and Steven A. Shallcross, and each of them singly, with full power of
  substitution, our true and lawful attorneys-in-fact and agents to take any actions to enable Vanda
  Pharmaceuticals Inc. to comply with the Securities Act, and any rules, regulations and requirements
  of the Securities and Exchange Commission, in connection with this registration statement,
  including the power and authority to sign for us in our names in the capacities indicated below any
  and all amendments (including post-effective amendments) to this registration statement and any
  other registration statement filed pursuant to the provisions of Rule 462 under the Securities Act
  and the power to file the same, with all exhibits thereto, and all other documents in connection
  therewith, with the Securities and Exchange Commission, granting unto each said attorney-in-fact
  and agents full power and authority to perform each and every act in person, hereby ratifying and
  confirming all that said attorneys-in-fact and agents or either of them or their or his substitute
  or substitutes may lawfully do or cause to be done by virtue hereof. This Power of Attorney may be
  signed in several counterparts.
  IN WITNESS WHEREOF
  , each of the undersigned has executed this Power of Attorney as of the date
  indicated.
  Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration
  Statement has been signed below by the following persons in the capacities and on the dates
  indicated.
  Name
  Title
  Date
  /s/ Mihael H. Polymeropoulos
  Mihael H. Polymeropoulos, M.D.
  President and Chief Executive
  Officer and Director
  (principal
  executive officer)
  January 29, 2008
  /s/ Steven A. Shallcross
  Steven A. Shallcross
  Senior Vice President, and Chief
  Financial Officer and
  Treasurer
  (principal financial and
  accounting officer)
  January 29, 2008
  /s/ Argeris N. Karabelas
  Argeris N. Karabelas, Ph.D.
  Director and Chairman of the Board
  January 29, 2008
  /s/ Brian K. Halak
  Brian K. Halak, Ph.D.
  Director
  January 29, 2008
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  Name
  Title
  Date
  /s/ H. Thomas Watkins
  H. Thomas Watkins
  Director
  January 29, 2008
  /s/ David Ramsay
  David Ramsay
  Director
  January 29, 2008
  /s/ Howard H. Pien
  Howard H. Pien
  Director
  January 29, 2008
  /s/ Richard W. Dugan
  Richard W. Dugan
  Director
  January 29, 2008
  II-5
  Table of Contents
  EXHIBIT INDEX
  Exhibit Number
  Exhibit
  4.1
  Reference is made to Vanda Pharmaceuticals Inc.'s Registration Statement No.
  000-51863 on Form 8-A, together with all amendments and exhibits thereto, which
  is incorporated herein by reference under Item 3(c) of this Registration
  Statement
  5.1
  Opinion and consent of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian,
  LLP
  23.1
  Consent of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP.
  (included in Exhibit 5)
  23.2
  Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting
  Firm
  24.1
  Power of Attorney: Reference is made to page II-4 of this Registration Statement