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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">As
  filed with the Securities and Exchange Commission on August&nbsp;12, 2008</DIV>
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">Registration No.&nbsp;333-<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549<BR>
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: pt"><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933<BR>
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>Molecular Insight Pharmaceuticals, Inc.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Massachusetts</B><BR>
  (State or other jurisdiction of <BR>
  incorporation or organization)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-0562086</B><BR>
  (I.R.S. Employer<BR>
  Identification No.)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><B>160 Second Street <BR>
  Cambridge, MA</B><BR>
  (Address of principal executive offices)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>02142</B><BR>
  (Zip Code)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Molecular Insight Pharmaceuticals, Inc.<BR>
  Amended and Restated 2006 Equity Incentive Plan</B><BR>
  (Full title of the plans)</DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top">David S. Barlow
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Copy to:</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Chairman and Chief Executive Officer <BR>
  160 Second Street <BR>
  Cambridge, MA 02142<BR>
  (617)&nbsp;492-5554<BR>
  (617)&nbsp;492-5664 - Fax<BR>
  (Name, address, including zip code, and telephone number, <BR>
  including area code, of agent for service)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Gabor Garai<BR>
  David W. Kantaros<BR>
  Foley &#038; Lardner LLP<BR>
  111 Huntington Avenue<BR>
  Boston, Massachusetts 02199<BR>
  (617)&nbsp;342-4000<BR>
  (617)&nbsp;342-4001 - Fax</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer,
  a non-accelerated filer, or a smaller reporting company.
  See the definitions of &#147;large
  accelerated filer,&#148; &#147;accelerated filer&#148; and &#147;smaller reporting company&#148; in Rule 12b-2 of the Exchange Act. (Check one):</DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="22%"></TD>
      <TD width="3%"></TD>
      <TD width="19%"></TD>
      <TD width="3%"></TD>
      <TD width="28%"></TD>
      <TD width="3%"></TD>
      <TD width="22%"></TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><FONT face="Wingdings">&#111;</FONT>&nbsp;&nbsp;&nbsp;Large accelerated filer
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><FONT face="Wingdings">&#111;</FONT>&nbsp;&nbsp;&nbsp;Accelerated filer&nbsp;&nbsp;&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><FONT face="Wingdings">&#254;</FONT> Non-accelerated filer
  </TD>
      <TD>&nbsp;</TD>
      <TD align="right" valign="top" nowrap><FONT face="Wingdings">&#111;</FONT>&nbsp;&nbsp;&nbsp;Smaller reporting company&nbsp;&nbsp;&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" colspan="0" nowrap>(Do not check if a smaller reporting company)</TD>
      <TD align="center" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt"></DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">CALCULATION OF REGISTRATION FEE</DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="26%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="27%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="9%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of Securities</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Offering Price Per</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Aggregate Offering</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">to be Registered</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Registered (1)</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Share (3)</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Price (3)</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Registration Fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD align="center" style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock,
  $.01 par value</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">998,126 shares (2)</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$8.30</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$8,284,446</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$325.58</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left">
  <DIV style="font-size: 6pt; margin-top: 1pt; width: 18%; border-top: 0px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>The provisions of Rule&nbsp;416 under the Securities Act of 1933, as amended shall apply to this
  Registration Statement and the number of shares registered on this Registration Statement shall
  increase or decrease as a result of stock splits, stock dividends, or similar transactions.
  Includes an indeterminate number of additional shares that may be issued to adjust the number of
  shares issued pursuant to the Plan described herein as the result of any future stock split, stock
  dividend, or similar adjustment of Registrant&#146;s outstanding common stock.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Represents 998,126 additional shares issuable pursuant to the grant or exercise of awards under
  the Registrant&#146;s Amended and Restated 2006 Equity Incentive Plan, which represents an automatic
  increase effective January&nbsp;1, 2008 equal to 4.0% of the total outstanding shares of the
  Registrant&#146;s common stock as of December&nbsp;31, 2007.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(3)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of calculating the registration fee. The fee is calculated
  pursuant to Rules 457(c) and 457(h) under the Securities Act of 1933 upon the basis of the average
  between the high and low sales prices for shares of common stock of the Registrant as reported on
  the Nasdaq Global Market on August&nbsp;8, 2008, which was $8.30.</TD>
  </TR>
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
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  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART I&nbsp;INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#001">PART II&nbsp;INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;4. Description of Securities</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;7. Exemption from Registration Claimed</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;8. Exhibits</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#008">Item&nbsp;9. Undertakings</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#009">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#010">EXHIBIT INDEX</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b70896miexv5w1.htm">EX-5.1 Opinion of Foley & Lardner LLP regarding legality of common stock.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b70896miexv23w1.htm">EX-23.1 Consent of Deloitte & Touche LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Explanatory Note</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Molecular Insight Pharmaceuticals, Inc. (the &#147;Company&#148; or &#147;Registrant&#148;) is filing this
  registration statement with the Securities and Exchange Commission
  (the &#147;Commission&#148;) to register an additional
  998,126 shares of common stock of the Registrant reserved for issuance under the Registrant&#146;s
  Amended and Restated 2006 Equity Incentive Plan (the &#147;Plan&#148;), authorized pursuant to annual
  automatic increase provisions of the Plan for the 2008 fiscal year. This Registration Statement
  has been prepared in accordance with General Instruction E to<BR>Form S-8.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant has previously registered 2,300,000 shares of the Registrant&#146;s common stock for
  issuance under the Plan pursuant to a Registration Statement on Form S-8 filed on May&nbsp;17, 2007
  (File No.&nbsp;333-143065).
  </DIV>
  &nbsp;
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "PART I&nbsp;INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART
  I</b></div>
  <DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The contents of the Registrant&#146;s previously filed Registration Statement on Forms S-8 (File
  Nos. 333-143065) relating to shares of common stock covered under the Registrant&#146;s Amended and
  Restated 2006 Equity Incentive Plan are hereby incorporated by reference.
  </DIV>
  <!-- link1 "PART II&nbsp;INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</b></div>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  </DIV>
  
  <!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;3. <U>Incorporation of Documents by Reference</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents have been previously filed by
  the Registrant with the Commission and are incorporated herein by reference:
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31, 2007,
  filed with the Commission on April&nbsp;1, 2008;
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;The Registrant&#146;s Definitive Proxy Statement for an annual meeting of stockholders
  held on May&nbsp;12, 2008, filed with the Commission on April&nbsp;11, 2008;
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;The Registrant&#146;s Quarterly Report on Form 10-Q for the fiscal quarter ended March&nbsp;31,
  2008, filed with the Commission on May&nbsp;14, 2008;
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;The Registrant&#146;s Current Reports on Form 8-K and Form 8-K/A, filed with the Commission on
  January&nbsp;25, 2008, March&nbsp;31, 2008, April&nbsp;1, 2008, May&nbsp;8, 2008, May&nbsp;14, 2008 and May&nbsp;21, 2008,
  respectively;
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;The section entitled &#147;Description of Registrant&#146;s Securities to be Registered&#148; contained
  in the Registrant&#146;s Registration Statement on Form 8-A, filed with the Commission pursuant to
  Section&nbsp;12(b) of the Securities Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;) on January
  30, 2007, and any amendments or reports filed for the purpose of updating such description.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents subsequently filed by the Registrant pursuant to Sections
  13(a), 13(c), 14, or 15(d) of the Exchange Act, after the date of filing of this Registration
  Statement and prior to the filing of a post-effective amendment to this Registration Statement that
  indicates that all securities offered hereby have been sold or which deregisters all securities
  then remaining unsold, shall be deemed to be incorporated by reference into this Registration
  Statement and to be a part hereof from the date of filing of such reports and documents. The
  information contained in any such reports and documents will automatically update and supersede any information
  previously incorporated by reference into this Registration Statement. Any such information so
  modified or superseded shall not be deemed, except as so modified or superseded, to constitute part
  of this Registration Statement.
  </DIV>
  <!-- link2 "Item&nbsp;4. Description of Securities" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;4. <U>Description of Securities</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;5. <U>Interests of Named Experts and Counsel</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;6. <U>Indemnification of Directors and Officers</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We are a Massachusetts corporation. Section&nbsp;2.02 of the Massachusetts Business Corporation
  Act, or MBCA, permits a corporation to eliminate or limit the personal liability of a director for
  monetary damages for
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->2<!-- /Folio -->
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">violations of the director&#146;s fiduciary duty, except for (i)&nbsp;any breach of the director&#146;s duty
  of loyalty to the corporation or its stockholders, (ii)&nbsp;acts or omissions not in good faith or
  which involve intentional misconduct or a knowing violation of law, (iii)&nbsp;for authorizing
  unauthorized distributions and for making loans to directors, officers and certain shareholders
  pursuant to Section&nbsp;6.40 of the MBCA or (iv)&nbsp;any transaction from which a director derived an
  improper personal benefit.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;8 of the MBCA provides that a corporation may indemnify directors, officers,
  employees and other agents and persons who serve at its request as directors, officers, employees
  or agents of another organization or who serve at its request in any capacity with respect to any
  employee benefit plan, to the extent specified or authorized by the articles of organization, any
  bylaw adopted by the stockholders or a vote adopted by the holders of a majority of the shares of
  stock entitled to vote on the election of directors. Such indemnification may include payment by the corporation of expenses incurred in defending
  a civil or criminal action or proceeding in advance of the final disposition of such action or
  proceeding, upon receipt of any undertaking by the person indemnified to repay such payment if he
  shall be adjudicated to be not entitled to indemnification under Section&nbsp;8 which undertaking may be
  accepted without reference to the financial ability of such person to make repayment. Any such
  indemnification may be provided although the person to be indemnified is no longer an officer,
  director, employee or agent of the corporation or of such other organization or no longer serves
  with respect to such employee benefit plan. No indemnification shall be provided, however, for any
  person with respect to any matter where there is a court determination that such person, in the
  matter in question, did not act in good faith in the reasonable belief that his action was in the
  best interest of the corporation or, to the extent that the matter relates to service with respect
  to an employee benefit plan, that such person did not act in the best interest of the participants
  or beneficiaries of such employee benefit plan.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We have also
  adopted provisions in our Restated Articles of Organization providing that our
  directors, officers, employees, and agents shall be indemnified to the fullest extent permitted by
  Massachusetts law. In addition to the indemnification granted to officers and directors under the MBCA,
  Article&nbsp;VI of our Restated Articles of Organization provides that each person who was or is made a
  party or is threatened to be made a party to or is otherwise involved in any action, suit or
  proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he
  or she is or was a director or an officer of the corporation or is or was serving at the request of
  the corporation as a director, officer, employee or agent of another corporation or of a
  partnership, joint venture, trust or other enterprise, including service with respect to an
  employee benefit plan, whether the basis of such proceeding is alleged action in an official
  capacity as a director, officer, employee or agent or in any other capacity while serving as a
  director, officer, employee or agent, shall be indemnified and held harmless by the corporation to
  the fullest extent authorized by the MBCA, as the same exists or may hereafter be amended against
  all expense, liability and loss (including attorneys&#146; fees, judgments, fines, ERISA excise taxes or
  penalties and amounts paid in settlement) reasonably incurred or suffered by such indemnitee in
  connection therewith.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The right to indemnification conferred in our Restated Articles of Organization includes, in
  the case of a director or officer at the level of vice president or above, and in the case of any
  other officer or any employee may include (in the discretion of the Board of Directors), the right
  to be paid by the Company the expenses incurred in defending any such proceeding in advance of its
  final disposition. The rights to indemnification and to the advancement of expenses conferred in
  our Restated Articles of Organization continue as to an indemnitee who has ceased to be a director,
  officer, employee or agent and inure to the benefit of the indemnitee&#146;s heirs, executors and
  administrators. We believe that these provisions are
  necessary to attract and retain qualified persons as directors and
  executive officers. Additionally, the Amended and Restated Bylaws permit us to secure insurance on
  behalf of any officer, director, employee, or other agent for any liability arising out of his or
  her actions in connection with their services to us, regardless of whether our articles or
  incorporation or bylaws permit such indemnification. We have obtained such insurance.
  
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->3<!-- /Folio -->
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;There is no pending litigation or proceeding involving our directors, officers, employees or
  agents pending for which indemnification is sought, nor are we aware of any pending or threatened
  litigation that may result in claims for indemnification by any director, officer, employee or
  other agent.
  </DIV>
  <!-- link2 "Item&nbsp;7. Exemption from Registration Claimed" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;7. <U>Exemption from Registration Claimed</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable.
  </DIV>
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;8. <U>Exhibits</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following exhibits have been filed (except where otherwise indicated) as part of this
  Registration Statement:
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="90%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B><I>Exhibit No.</I></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><I>Exhibit Description</I></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1(1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen certificate representing the Common Stock</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Foley &#038; Lardner LLP regarding legality of common stock</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Foley &#038; Lardner LLP (contained in Exhibit&nbsp;5.1 hereto)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney relating to subsequent amendments (included on
  the signature page to this Registration Statement)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1(2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Molecular Insight Pharmaceuticals, Inc.&#146;s Amended and Restated
  2006 Equity Incentive Plan</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Incorporated by reference to Exhibit&nbsp;4.2 previously filed with the Registrant&#146;s
  Registration Statement on Form S-1 filed with the Commission, as amended (Registration
  No.&nbsp;333-129570), as declared effective on February&nbsp;1, 2007.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Incorporated by reference to Exhibit&nbsp;10.19 previously filed with the
  Registrant&#146;s Registration Statement on Form S-1 filed with the Commission, as amended
  (Registration No.&nbsp;333-129570), as declared effective on February&nbsp;1, 2007.</TD>
  </TR>
  
  </TABLE>
  
  
  <!-- link2 "Item&nbsp;9. Undertakings" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt">Item&nbsp;9. <U>Undertakings</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.&nbsp;The undersigned Registrant hereby undertakes:
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;To file, during any period in which offers or sales are being made, a post-effective
  amendment to this registration statement:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;To
  include any prospectus required by section 10(a)(3) of the Securities
  Act of 1933, as amended (the &#147;Securities
  Act&#148;);
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;To reflect in the prospectus any facts or events arising after the effective date of this
  registration statement (or the most recent post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the information set forth in this registration
  statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
  (if the total dollar value of securities offered would not exceed that which was registered) and
  any deviation from the low or high end of the estimated maximum offering range may be reflected in
  the form of prospectus filed with the Commission pursuant to Rule 424(b) of the
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->4<!-- /Folio -->
  </DIV>
  
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Securities Act, if, in the aggregate, the changes in volume and price represent no more than a
  20% change in the maximum aggregate offering price set forth in the &#147;Calculation of Registration
  Fee&#148; table in this Registration Statement; and
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;To include any material information with respect to the plan of distribution not
  previously disclosed in this Registration Statement or any material change to such information in
  this Registration Statement.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;PROVIDED, HOWEVER, that paragraphs (a)(i) and (a)(ii) above do not apply if the registration
  statement is on Form&nbsp;S-8 and the information required to be included in a
  post-effective amendment by those paragraphs is contained in periodic
  reports filed with or furnished to the Commission by the
  Registrant pursuant to Section&nbsp;13 or Section 15(d) of the Exchange Act that are incorporated by
  reference herein.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;That, for the purpose of determining any liability under the Securities Act, each such
  post-effective amendment shall be deemed to be a new registration statement relating to the
  securities offered herein, and the offering of such securities at that time shall be deemed to be
  the initial bona fide offering thereof.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;The undersigned Registrant hereby undertakes that, for purposes of determining any
  liability under the Securities Act, each filing of the registrant&#146;s annual report pursuant to
  Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an
  employee benefit plan&#146;s annual report pursuant to section 15(d) of the Exchange Act) that is
  incorporated by reference in the Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered herein, and the offering of such securities at that
  time shall be deemed to be the initial bona fide offering thereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.&nbsp;Insofar as indemnification for liabilities arising under the Securities Act may be
  permitted to directors, officers and controlling persons of the registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Commission such indemnification is against public policy as expressed in the Securities Act and is,
  therefore, unenforceable. In the event that a claim for indemnification against such liabilities
  (other than the payment by the registrant of expenses incurred or paid by a director, officer or
  controlling person of the Registrant in the successful defense of any action, suit or proceeding)
  is asserted by such director, officer or controlling person in connection with the securities being
  registered, the Registrant will, unless in the opinion of its counsel the matter has been settled
  by controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities Act and will be
  governed by the final adjudication of such issue.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->5<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
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  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="009"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
  certifies that it has reasonable grounds to believe that it meets all the requirements for filing
  on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the
  undersigned, thereunto duly authorized, in the City of Boston, and Commonwealth of Massachusetts,
  on this
  12th&nbsp;day of August, 2008.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left" nowrap>MOLECULAR INSIGHT PHARMACEUTICALS, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ David S. Barlow
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">David S. Barlow&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Chairman and Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY AND SIGNATURES</B>
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints David S. Barlow his true
  and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him
  in his name, place and stead, in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement and any Rule 462(b) Registration
  Statement and to file the same, with all exhibits thereto, and other documents in connection
  therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and
  agent full power and authority to do and perform each and every act and thing requisite and
  necessary to be done in connection therewith, as fully to all intents and purposes as he might or
  could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or
  his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration
  Statement has been signed by the following persons in the capacities
  below on the 12th&nbsp;day of
  August, 2008.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="35%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="60%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B><I>Signature</I></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><I>Title</I></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ David S. Barlow
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  David S. Barlow
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chairman of the Board and Chief Executive Officer
  (Principal Executive Officer)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ John W. Babich
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  John W. Babich
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director; President and Chief Scientific Officer&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Donald E. Wallroth
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Donald E. Wallroth
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chief Financial Officer (Principal Financial Officer
  and Principal Accounting Officer)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Daniel Frank
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Daniel Frank
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ David M. Stack
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  David M. Stack
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->6<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="35%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="60%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B><I>Signature</I></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><I>Title</I></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Harry Stylli
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Harry Stylli
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Lionel Sterling
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Lionel Sterling
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Scott Gottlieb
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Scott Gottlieb
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->7<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "EXHIBIT INDEX" -->
  <DIV align="left"><A NAME="010"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXHIBIT INDEX</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="90%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><B><I>Exhibit No.</I></B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left"><B><I>Exhibit Description</I></B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1(1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen certificate representing the Common Stock</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Foley &#038; Lardner LLP regarding legality of common stock</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Foley &#038; Lardner LLP (contained in Exhibit&nbsp;5.1 hereto)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney relating to subsequent amendments (included on
  the signature page to this Registration Statement)</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1(2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Molecular Insight Pharmaceuticals, Inc.&#146;s Amended and Restated
  2006 Equity Incentive Plan</TD>
  </TR>
  <!-- End Table Body -->
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  </DIV>
  
  
  
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      <TD width="1%"></TD>
      <TD width="96"></TD>
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      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Incorporated by reference to Exhibit&nbsp;4.2 previously filed with the Registrant&#146;s Registration
  Statement on Form S-1 filed with the Commission, as amended (Registration No.&nbsp;333-129570), as
  declared effective on February&nbsp;1, 2007.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Incorporated by reference to Exhibit&nbsp;10.19 previously filed with the Registrant&#146;s
  Registration Statement on Form S-1 filed with the Commission, as amended (Registration No.
  333-129570), as declared effective on February&nbsp;1, 2007.</TD>
  </TR>
  
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text: sv8
  Table of Contents
  As
  filed with the Securities and Exchange Commission on August 12, 2008
  Registration No. 333-
  SECURITIES AND EXCHANGE COMMISSION
  Washington, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
  Molecular Insight Pharmaceuticals, Inc.
  (Exact name of registrant as specified in its charter)
  Massachusetts
  (State or other jurisdiction of
  incorporation or organization)
  04-0562086
  (I.R.S. Employer
  Identification No.)
  160 Second Street
  Cambridge, MA
  (Address of principal executive offices)
  02142
  (Zip Code)
  Molecular Insight Pharmaceuticals, Inc.
  Amended and Restated 2006 Equity Incentive Plan
  (Full title of the plans)
  David S. Barlow
  Copy to:
  Chairman and Chief Executive Officer
  160 Second Street
  Cambridge, MA 02142
  (617) 492-5554
  (617) 492-5664 - Fax
  (Name, address, including zip code, and telephone number,
  including area code, of agent for service)
  Gabor Garai
  David W. Kantaros
  Foley & Lardner LLP
  111 Huntington Avenue
  Boston, Massachusetts 02199
  (617) 342-4000
  (617) 342-4001 - Fax
  Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer,
  a non-accelerated filer, or a smaller reporting company.
  See the definitions of "large
  accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act. (Check one):
  o
  Large accelerated filer
  o
  Accelerated filer
  þ
  Non-accelerated filer
  o
  Smaller reporting company
  (Do not check if a smaller reporting company)
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  Maximum
  Maximum
  Title of Securities
  Amount to be
  Offering Price Per
  Aggregate Offering
  Amount of
  to be Registered
  Registered (1)
  Share (3)
  Price (3)
  Registration Fee
  Common Stock,
  $.01 par value
  998,126 shares (2)
  $8.30
  $8,284,446
  $325.58
  (1)
  The provisions of Rule 416 under the Securities Act of 1933, as amended shall apply to this
  Registration Statement and the number of shares registered on this Registration Statement shall
  increase or decrease as a result of stock splits, stock dividends, or similar transactions.
  Includes an indeterminate number of additional shares that may be issued to adjust the number of
  shares issued pursuant to the Plan described herein as the result of any future stock split, stock
  dividend, or similar adjustment of Registrant's outstanding common stock.
  (2)
  Represents 998,126 additional shares issuable pursuant to the grant or exercise of awards under
  the Registrant's Amended and Restated 2006 Equity Incentive Plan, which represents an automatic
  increase effective January 1, 2008 equal to 4.0% of the total outstanding shares of the
  Registrant's common stock as of December 31, 2007.
  (3)
  Estimated solely for the purpose of calculating the registration fee. The fee is calculated
  pursuant to Rules 457(c) and 457(h) under the Securities Act of 1933 upon the basis of the average
  between the high and low sales prices for shares of common stock of the Registrant as reported on
  the Nasdaq Global Market on August 8, 2008, which was $8.30.
  TABLE OF CONTENTS
  PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference
  Item 4. Description of Securities
  Item 5. Interests of Named Experts and Counsel
  Item 6. Indemnification of Directors and Officers
  Item 7. Exemption from Registration Claimed
  Item 8. Exhibits
  Item 9. Undertakings
  SIGNATURES
  EXHIBIT INDEX
  EX-5.1 Opinion of Foley & Lardner LLP regarding legality of common stock.
  EX-23.1 Consent of Deloitte & Touche LLP
  Table of Contents
  Explanatory Note
  Molecular Insight Pharmaceuticals, Inc. (the "Company" or "Registrant") is filing this
  registration statement with the Securities and Exchange Commission
  (the "Commission") to register an additional
  998,126 shares of common stock of the Registrant reserved for issuance under the Registrant's
  Amended and Restated 2006 Equity Incentive Plan (the "Plan"), authorized pursuant to annual
  automatic increase provisions of the Plan for the 2008 fiscal year. This Registration Statement
  has been prepared in accordance with General Instruction E to
  Form S-8.
  The Registrant has previously registered 2,300,000 shares of the Registrant's common stock for
  issuance under the Plan pursuant to a Registration Statement on Form S-8 filed on May 17, 2007
  (File No. 333-143065).
  Table of Contents
  PART
  I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  The contents of the Registrant's previously filed Registration Statement on Forms S-8 (File
  Nos. 333-143065) relating to shares of common stock covered under the Registrant's Amended and
  Restated 2006 Equity Incentive Plan are hereby incorporated by reference.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference
  .
  The following documents have been previously filed by
  the Registrant with the Commission and are incorporated herein by reference:
  (a) The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2007,
  filed with the Commission on April 1, 2008;
  (b) The Registrant's Definitive Proxy Statement for an annual meeting of stockholders
  held on May 12, 2008, filed with the Commission on April 11, 2008;
  (c) The Registrant's Quarterly Report on Form 10-Q for the fiscal quarter ended March 31,
  2008, filed with the Commission on May 14, 2008;
  (d) The Registrant's Current Reports on Form 8-K and Form 8-K/A, filed with the Commission on
  January 25, 2008, March 31, 2008, April 1, 2008, May 8, 2008, May 14, 2008 and May 21, 2008,
  respectively;
  (e) The section entitled "Description of Registrant's Securities to be Registered" contained
  in the Registrant's Registration Statement on Form 8-A, filed with the Commission pursuant to
  Section 12(b) of the Securities Exchange Act of 1934, as amended (the "Exchange Act") on January
  30, 2007, and any amendments or reports filed for the purpose of updating such description.
  All reports and other documents subsequently filed by the Registrant pursuant to Sections
  13(a), 13(c), 14, or 15(d) of the Exchange Act, after the date of filing of this Registration
  Statement and prior to the filing of a post-effective amendment to this Registration Statement that
  indicates that all securities offered hereby have been sold or which deregisters all securities
  then remaining unsold, shall be deemed to be incorporated by reference into this Registration
  Statement and to be a part hereof from the date of filing of such reports and documents. The
  information contained in any such reports and documents will automatically update and supersede any information
  previously incorporated by reference into this Registration Statement. Any such information so
  modified or superseded shall not be deemed, except as so modified or superseded, to constitute part
  of this Registration Statement.
  Item 4.
  Description of Securities
  .
  Not applicable.
  Item 5.
  Interests of Named Experts and Counsel
  .
  Not applicable.
  Item 6.
  Indemnification of Directors and Officers
  .
  We are a Massachusetts corporation. Section 2.02 of the Massachusetts Business Corporation
  Act, or MBCA, permits a corporation to eliminate or limit the personal liability of a director for
  monetary damages for
  2
  Table of Contents
  violations of the director's fiduciary duty, except for (i) any breach of the director's duty
  of loyalty to the corporation or its stockholders, (ii) acts or omissions not in good faith or
  which involve intentional misconduct or a knowing violation of law, (iii) for authorizing
  unauthorized distributions and for making loans to directors, officers and certain shareholders
  pursuant to Section 6.40 of the MBCA or (iv) any transaction from which a director derived an
  improper personal benefit.
  Section 8 of the MBCA provides that a corporation may indemnify directors, officers,
  employees and other agents and persons who serve at its request as directors, officers, employees
  or agents of another organization or who serve at its request in any capacity with respect to any
  employee benefit plan, to the extent specified or authorized by the articles of organization, any
  bylaw adopted by the stockholders or a vote adopted by the holders of a majority of the shares of
  stock entitled to vote on the election of directors. Such indemnification may include payment by the corporation of expenses incurred in defending
  a civil or criminal action or proceeding in advance of the final disposition of such action or
  proceeding, upon receipt of any undertaking by the person indemnified to repay such payment if he
  shall be adjudicated to be not entitled to indemnification under Section 8 which undertaking may be
  accepted without reference to the financial ability of such person to make repayment. Any such
  indemnification may be provided although the person to be indemnified is no longer an officer,
  director, employee or agent of the corporation or of such other organization or no longer serves
  with respect to such employee benefit plan. No indemnification shall be provided, however, for any
  person with respect to any matter where there is a court determination that such person, in the
  matter in question, did not act in good faith in the reasonable belief that his action was in the
  best interest of the corporation or, to the extent that the matter relates to service with respect
  to an employee benefit plan, that such person did not act in the best interest of the participants
  or beneficiaries of such employee benefit plan.
  We have also
  adopted provisions in our Restated Articles of Organization providing that our
  directors, officers, employees, and agents shall be indemnified to the fullest extent permitted by
  Massachusetts law. In addition to the indemnification granted to officers and directors under the MBCA,
  Article VI of our Restated Articles of Organization provides that each person who was or is made a
  party or is threatened to be made a party to or is otherwise involved in any action, suit or
  proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he
  or she is or was a director or an officer of the corporation or is or was serving at the request of
  the corporation as a director, officer, employee or agent of another corporation or of a
  partnership, joint venture, trust or other enterprise, including service with respect to an
  employee benefit plan, whether the basis of such proceeding is alleged action in an official
  capacity as a director, officer, employee or agent or in any other capacity while serving as a
  director, officer, employee or agent, shall be indemnified and held harmless by the corporation to
  the fullest extent authorized by the MBCA, as the same exists or may hereafter be amended against
  all expense, liability and loss (including attorneys' fees, judgments, fines, ERISA excise taxes or
  penalties and amounts paid in settlement) reasonably incurred or suffered by such indemnitee in
  connection therewith.
  The right to indemnification conferred in our Restated Articles of Organization includes, in
  the case of a director or officer at the level of vice president or above, and in the case of any
  other officer or any employee may include (in the discretion of the Board of Directors), the right
  to be paid by the Company the expenses incurred in defending any such proceeding in advance of its
  final disposition. The rights to indemnification and to the advancement of expenses conferred in
  our Restated Articles of Organization continue as to an indemnitee who has ceased to be a director,
  officer, employee or agent and inure to the benefit of the indemnitee's heirs, executors and
  administrators. We believe that these provisions are
  necessary to attract and retain qualified persons as directors and
  executive officers. Additionally, the Amended and Restated Bylaws permit us to secure insurance on
  behalf of any officer, director, employee, or other agent for any liability arising out of his or
  her actions in connection with their services to us, regardless of whether our articles or
  incorporation or bylaws permit such indemnification. We have obtained such insurance.
  3
  Table of Contents
  There is no pending litigation or proceeding involving our directors, officers, employees or
  agents pending for which indemnification is sought, nor are we aware of any pending or threatened
  litigation that may result in claims for indemnification by any director, officer, employee or
  other agent.
  Item 7.
  Exemption from Registration Claimed
  .
  Not Applicable.
  Item 8.
  Exhibits
  .
  The following exhibits have been filed (except where otherwise indicated) as part of this
  Registration Statement:
  Exhibit No.
  Exhibit Description
  4.1(1)
  Specimen certificate representing the Common Stock
  5.1
  Opinion of Foley & Lardner LLP regarding legality of common stock
  23.1
  Consent of Deloitte & Touche LLP
  23.2
  Consent of Foley & Lardner LLP (contained in Exhibit 5.1 hereto)
  24.1
  Power of Attorney relating to subsequent amendments (included on
  the signature page to this Registration Statement)
  99.1(2)
  Molecular Insight Pharmaceuticals, Inc.'s Amended and Restated
  2006 Equity Incentive Plan
  (1)
  Incorporated by reference to Exhibit 4.2 previously filed with the Registrant's
  Registration Statement on Form S-1 filed with the Commission, as amended (Registration
  No. 333-129570), as declared effective on February 1, 2007.
  (2)
  Incorporated by reference to Exhibit 10.19 previously filed with the
  Registrant's Registration Statement on Form S-1 filed with the Commission, as amended
  (Registration No. 333-129570), as declared effective on February 1, 2007.
  Item 9.
  Undertakings
  .
  1. The undersigned Registrant hereby undertakes:
  (a) To file, during any period in which offers or sales are being made, a post-effective
  amendment to this registration statement:
  (i) To
  include any prospectus required by section 10(a)(3) of the Securities
  Act of 1933, as amended (the "Securities
  Act");
  (ii) To reflect in the prospectus any facts or events arising after the effective date of this
  registration statement (or the most recent post-effective amendment thereof) which, individually or
  in the aggregate, represent a fundamental change in the information set forth in this registration
  statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
  (if the total dollar value of securities offered would not exceed that which was registered) and
  any deviation from the low or high end of the estimated maximum offering range may be reflected in
  the form of prospectus filed with the Commission pursuant to Rule 424(b) of the
  4
  Table of Contents
  Securities Act, if, in the aggregate, the changes in volume and price represent no more than a
  20% change in the maximum aggregate offering price set forth in the "Calculation of Registration
  Fee" table in this Registration Statement; and
  (iii) To include any material information with respect to the plan of distribution not
  previously disclosed in this Registration Statement or any material change to such information in
  this Registration Statement.
  PROVIDED, HOWEVER, that paragraphs (a)(i) and (a)(ii) above do not apply if the registration
  statement is on Form S-8 and the information required to be included in a
  post-effective amendment by those paragraphs is contained in periodic
  reports filed with or furnished to the Commission by the
  Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by
  reference herein.
  (b) That, for the purpose of determining any liability under the Securities Act, each such
  post-effective amendment shall be deemed to be a new registration statement relating to the
  securities offered herein, and the offering of such securities at that time shall be deemed to be
  the initial bona fide offering thereof.
  (c) To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  2. The undersigned Registrant hereby undertakes that, for purposes of determining any
  liability under the Securities Act, each filing of the registrant's annual report pursuant to
  Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an
  employee benefit plan's annual report pursuant to section 15(d) of the Exchange Act) that is
  incorporated by reference in the Registration Statement shall be deemed to be a new registration
  statement relating to the securities offered herein, and the offering of such securities at that
  time shall be deemed to be the initial bona fide offering thereof.
  3. Insofar as indemnification for liabilities arising under the Securities Act may be
  permitted to directors, officers and controlling persons of the registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Commission such indemnification is against public policy as expressed in the Securities Act and is,
  therefore, unenforceable. In the event that a claim for indemnification against such liabilities
  (other than the payment by the registrant of expenses incurred or paid by a director, officer or
  controlling person of the Registrant in the successful defense of any action, suit or proceeding)
  is asserted by such director, officer or controlling person in connection with the securities being
  registered, the Registrant will, unless in the opinion of its counsel the matter has been settled
  by controlling precedent, submit to a court of appropriate jurisdiction the question whether such
  indemnification by it is against public policy as expressed in the Securities Act and will be
  governed by the final adjudication of such issue.
  5
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
  certifies that it has reasonable grounds to believe that it meets all the requirements for filing
  on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the
  undersigned, thereunto duly authorized, in the City of Boston, and Commonwealth of Massachusetts,
  on this
  12th day of August, 2008.
  MOLECULAR INSIGHT PHARMACEUTICALS, INC.
  By:
  /s/ David S. Barlow
  David S. Barlow
  Chairman and Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  Each person whose signature appears below constitutes and appoints David S. Barlow his true
  and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him
  in his name, place and stead, in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement and any Rule 462(b) Registration
  Statement and to file the same, with all exhibits thereto, and other documents in connection
  therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and
  agent full power and authority to do and perform each and every act and thing requisite and
  necessary to be done in connection therewith, as fully to all intents and purposes as he might or
  could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or
  his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration
  Statement has been signed by the following persons in the capacities
  below on the 12th day of
  August, 2008.
  Signature
  Title
  /s/ David S. Barlow
  David S. Barlow
  Chairman of the Board and Chief Executive Officer
  (Principal Executive Officer)
  /s/ John W. Babich
  John W. Babich
  Director; President and Chief Scientific Officer
  /s/ Donald E. Wallroth
  Donald E. Wallroth
  Chief Financial Officer (Principal Financial Officer
  and Principal Accounting Officer)
  /s/ Daniel Frank
  Daniel Frank
  Director
  /s/ David M. Stack
  David M. Stack
  Director
  6
  Table of Contents
  Signature
  Title
  /s/ Harry Stylli
  Harry Stylli
  Director
  /s/ Lionel Sterling
  Lionel Sterling
  Director
  /s/ Scott Gottlieb
  Scott Gottlieb
  Director
  7
  Table of Contents
  EXHIBIT INDEX
  Exhibit No.
  Exhibit Description
  4.1(1)
  Specimen certificate representing the Common Stock
  5.1
  Opinion of Foley & Lardner LLP regarding legality of common stock
  23.1
  Consent of Deloitte & Touche LLP
  23.2
  Consent of Foley & Lardner LLP (contained in Exhibit 5.1 hereto)
  24.1
  Power of Attorney relating to subsequent amendments (included on
  the signature page to this Registration Statement)
  99.1(2)
  Molecular Insight Pharmaceuticals, Inc.'s Amended and Restated
  2006 Equity Incentive Plan
  (1)
  Incorporated by reference to Exhibit 4.2 previously filed with the Registrant's Registration
  Statement on Form S-1 filed with the Commission, as amended (Registration No. 333-129570), as
  declared effective on February 1, 2007.
  (2)
  Incorporated by reference to Exhibit 10.19 previously filed with the Registrant's
  Registration Statement on Form S-1 filed with the Commission, as amended (Registration No.
  333-129570), as declared effective on February 1, 2007.
  8