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  <TITLE>Alkermes, Inc.</TITLE>
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  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <P align="right" style="font-size: 10pt">As filed with the Securities and Exchange Commission on April&nbsp;22, 2005
  
  
  
  <P align="right" style="font-size: 10pt">Registration No.&nbsp;333-______
  
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><HR size="1" noshade width="26%" align="center" color="#000000">
  
  
  <P align="center" style="font-size: 18pt"><B>FORM S-8</B>
  
  
  <P align="center" style="font-size: 10pt">REGISTRATION STATEMENT UNDER<BR>
  THE SECURITIES ACT OF 1933
  
  
  
  <P align="center" style="font-size: 10pt"><HR size="1" noshade width="26%" align="center" color="#000000">
  
  
  <P align="center" style="font-size: 24pt"><B>Alkermes, Inc.</B>
  
  
  <DIV align="center" style="font-size: 10pt">(Exact Name of Registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
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  <!-- Begin Table Head -->
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      <TD width="47%">&nbsp;</TD>
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      <TD width="47%">&nbsp;</TD>
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      <TD align="center" valign="top"><B>Pennsylvania</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>23-2472830</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or other jurisdiction of incorporation or
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">organization)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
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  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><B>ALKERMES, INC.<BR>
  88 SIDNEY STREET<BR>
  CAMBRIDGE, MASSACHUSETTS 02139-4234<BR>
  TELEPHONE: (617)&nbsp;494-0171</B><BR>
  (Address, including zip code, and telephone number, including area code,<BR>
  of registrant&#146;s principal executive offices)
  
  
  
  <P align="center" style="font-size: 10pt"><B>ALKERMES, INC. 1999 STOCK OPTION PLAN</B><BR>
  (Full title of the plan)
  
  
  
  <P align="center" style="font-size: 10pt">Richard F. Pops<BR>
  Chief Executive Officer<BR>
  ALKERMES, INC.<BR>
  88 Sidney Street<BR>
  Cambridge, Massachusetts 02139-4234<BR>
  Telephone: (617)&nbsp;494-0171<BR>
  (Name, address, including zip code, and telephone number, including area code,<BR>
  of agent for service)
  
  
  
  <P align="center" style="font-size: 10pt"><HR size="1" noshade width="26%" align="center" color="#000000">
  
  
  
  <P align="center" style="font-size: 10pt">Copies to:
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="70%">
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      <TD width="45%">&nbsp;</TD>
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  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Mitchell S. Bloom, Esq.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Kathryn L. Biberstein, Esq.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Goodwin Procter LLP
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Alkermes, Inc.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">53 State Street
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">88 Sidney Street</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Boston, MA 02109
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Cambridge, MA 02139</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Telephone: (617)&nbsp;570-1055
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Telephone: (617)&nbsp;583-6255</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;</DIV>
  
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  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>
  
  
  
  <P align="center" style="font-size: 10pt"><DIV style="border-bottom: 1px solid #000000; font-size: 1px">&nbsp;</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="44%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Proposed</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Maximum</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Proposed</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Offering</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Maximum</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Title of Securities</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Amount to be</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Price Per</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Aggregate</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2">Amount of</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">to be Registered</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2" style="border-bottom: 1px solid #000000">Registered<SUP style="font-size: 85%; vertical-align: text-top">(1)(4)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2" style="border-bottom: 1px solid #000000">Share</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2" style="border-bottom: 1px solid #000000">Offering Price</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="2" style="border-bottom: 1px solid #000000">Registration Fee</TD>
      <TD>&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="background: #cceeff">
      <TD><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value $.01 per share</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">1,058,676</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">14.90</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">15,774,272.40</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">1,856.63</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">250</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">14.89</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">3,722.50</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">0.44</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="background: #cceeff">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">6,500</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">13.12</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">85,280.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">10.04</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">6,500</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">12.63</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">82,095.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">9.66</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="background: #cceeff">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">750</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">12.75</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">9,562.50</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">1.13</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">2,500</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">12.73</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">31,825.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">3.75</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="background: #cceeff">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">500</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">11.54</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">5,770.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">0.68</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">80,000</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">11.63</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">930,400.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">109.51</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="background: #cceeff">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">6,750</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">11.20</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">75,600.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">8.90</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">1,000</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">10.63</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">10,630.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">1.25</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="background: #cceeff">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">6,000</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">10.25</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">61,500.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">7.24</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">10,000</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">10.60</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">106,000.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">12.48</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="background: #cceeff">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">&nbsp;</TD>
      <TD align="right">1,000</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">11.03</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">11,030.00</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">1.30</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">1,319,574</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left">$</TD>
      <TD align="right">11.67</TD>
      <TD nowrap><SUP style="font-size: 85%; vertical-align: text-top">(3)</SUP></TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">15,399,428.58</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">1,812.51</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD nowrap colspan="2" align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap colspan="2" align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap colspan="2" align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap colspan="2" align="right" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="background: #cceeff">
      <TD><DIV style="margin-left:15px; text-indent:-15px">TOTALS:</DIV></TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="right">2,500,000</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">32,587,115.98</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left">$</TD>
      <TD align="right">3,835.50</TD>
      <TD>&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><DIV style="border-bottom: 1px solid #000000; font-size: 1px">&nbsp;</DIV>
  
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(1)&nbsp;&nbsp;</TD>
      <TD>Pursuant to Rule&nbsp;416 under the Securities Act of 1933, this registration statement shall
  also be deemed to cover an indeterminate number of additional shares of Common Stock issuable
  in the event the number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend, recapitalization, and certain other capital adjustments and
  the like.</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(2)&nbsp;&nbsp;</TD>
      <TD>Such shares are issuable upon the exercise of outstanding options with fixed exercise prices.
  Pursuant to Rule&nbsp;457(h), the aggregate offering price and fee have been computed upon the
  basis of the price at which such options may be exercised. The offering price per share set
  forth for such shares is the exercise price per share at which such options are exercisable.</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(3)&nbsp;&nbsp;</TD>
      <TD>Estimated solely for the purpose of calculating the registration fee. In accordance with
  Rules&nbsp;457 (c)&nbsp;and 457(h), the proposed maximum offering price per share, the proposed maximum
  aggregate offering price, and the registration fee shown has been computed based upon the
  average of the high and low price of the Company&#146;s Common Stock on April&nbsp;20, 2005, $11.67, as
  reported on the Nasdaq National Market with respect to securities for which options have not
  been granted.</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(4)&nbsp;&nbsp;</TD>
      <TD>This registration statement relates 2,500,000 shares of Common Stock, $.01 par value per
  share, reserved for issuance under the 1999 Stock Option Plan (the &#147;1999 Plan&#148;), which shares
  are in addition to 14,400,000 shares of Common Stock, $.01 par value per share, previously
  registered pursuant to Registration Statements on Form S-8 (Registration Nos. 333-89573,
  333-48772, 333-72988, 333-107206 and 333-109376) and filed with the Securities and Exchange
  Commission. The current filing is being made to register the 2,500,000 shares which are
  issuable under the 1999 Plan.</TD>
  </TR>
  
  </TABLE>
  
  <P align="center" style="font-size: 10pt">-2-</DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <P><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  
  </TABLE>
  
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART I</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#001">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;3. <U>Incorporation of Documents by Reference</U>.</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;4. <U>Description of Securities.</U></A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;5. <U>Interests of Named Experts and Counsel.</U></A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;8. <U>Exhibits</U>.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#006">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#007">INDEX TO EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b54748akexv4w2.txt">Ex-4.2 Specimen of Non-Voting Common Stock Certificate</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b54748akexv5w1.txt">Ex-5.1 Opinion of Goodwin Proctor LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b54748akexv23w2.txt">Ex-23.2 Consent of Deloitte & Touche LLP</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b54748akexv23w3.txt">Ex-23.3 Consent of Ernst & Young LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  <!-- link1 "PART I" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>PART I</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Part&nbsp;I and Items 6, 7 and 9 of Part&nbsp;II of Alkermes, Inc.&#146;s Registration Statement on Form S-8
  (File No.&nbsp;333-89573) are incorporated by reference herein pursuant to Instruction E of Form S-8.
  
  <!-- link1 "PART II" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>PART II</B>
  
  
  
  <P align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  
  <!-- link2 "Item&nbsp;3. <U>Incorporation of Documents by Reference</U>." -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <P align="left" style="font-size: 10pt">Item&nbsp;3. <U>Incorporation of Documents by Reference</U>.
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed with the Securities and Exchange Commission (the &#147;Commission&#148;)
  pursuant to the Securities Exchange Act of 1934 (the &#147;Exchange Act&#148;) by Alkermes, Inc. (the
  &#147;Company&#148;) (File No.&nbsp;1-14131) or pursuant to the Securities Act of 1933, as amended (the
  &#147;Securities Act&#148;) are incorporated herein by reference:
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(a)&nbsp;&nbsp;</TD>
      <TD>Annual Report on Form 10-K for the fiscal year ended March&nbsp;31, 2004;</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)&nbsp;&nbsp;</TD>
      <TD>Quarterly Reports on Form 10-Q for the periods ended June&nbsp;30, 2004, September&nbsp;30, 2004 and
  December&nbsp;31, 2004;</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(c)&nbsp;&nbsp;</TD>
      <TD>All other documents filed by the Company pursuant to 13(a) or 15(d) of the Exchange Act since
  the end of the fiscal year covered by the document referred to in (a)&nbsp;above; and</TD>
  </TR>
  
  </TABLE>
  
  
  <P>
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(d)&nbsp;&nbsp;</TD>
      <TD>Item&nbsp;1 of Registration Statement of the Company on Form 8-A dated June&nbsp;28, 1991, as amended
  by a Registration Statement of the Company on Form 8-A/A dated January&nbsp;17, 1997; and Item&nbsp;1 of
  Registration Statement of the Company on Form 8-A dated May&nbsp;2, 2003.</TD>
  </TR>
  
  </TABLE>
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14 or 15(d) of the
  Exchange Act, after the date of this Registration Statement and prior to the filing of a
  post-effective amendment which indicates that all securities offered herein have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference
  herein and to be part hereof from the date of filing such documents. Any statement contained herein
  or in a document incorporated by reference or deemed to be incorporated by reference herein shall
  be deemed to be modified or superseded for purposes of this Registration Statement to the extent
  that such statement is modified or superseded by any other subsequently filed document which is
  incorporated or is deemed to be incorporated by reference herein. Any such statement so modified or
  superseded shall not be deemed, except as so modified or superseded, to constitute a part of this
  Registration Statement.
  
  <!-- link2 "Item&nbsp;4. <U>Description of Securities.</U>" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <P align="left" style="font-size: 10pt">Item&nbsp;4. <U>Description of Securities.</U>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable
  
  <!-- link2 "Item&nbsp;5. <U>Interests of Named Experts and Counsel.</U>" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <P align="left" style="font-size: 10pt">Item&nbsp;5. <U>Interests of Named Experts and Counsel.</U>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable.
  
  <!-- link2 "Item&nbsp;8. <U>Exhibits</U>." -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <P align="left" style="font-size: 10pt">Item&nbsp;8. <U>Exhibits</U>.
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Reference is made to the Exhibit&nbsp;Index.
  
  
  
  <P align="center" style="font-size: 10pt">-3-</DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>SIGNATURES</B>
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the City of Cambridge, in the Commonwealth of Massachusetts, on this
  22nd day of April, 2005.
  
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left">ALKERMES, INC.<BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
  
  <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/
  Richard&nbsp;F. Pops
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Richard F. Pops&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <P align="CENTER" style="font-size: 10pt"><B>POWER OF ATTORNEY AND SIGNATURES</B>
  
  
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed below by the following persons in the capacities and on the dates indicated.
  
  
  <P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below in so signing also makes, constitutes and appoints
  Richard F. Pops and James M. Frates, and each of them, his true and lawful attorney-in-fact, with
  full power of substitution, for him in any and all capacities, to execute and cause to be filed
  with the Securities and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in connection therewith, and
  hereby ratifies and confirms all that said attorney-in-fact or his substitute or substitutes may do
  or cause to be done by virtue hereof.
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="25%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="45%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center"><U><B>SIGNATURE</B></U></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><U><B>TITLE</B></U></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><U><B>DATE</B></U></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" nowrap valign="top"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Michael&nbsp;A. Wall
  <HR size="1" noshade color="#000000">
  Michael A. Wall</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director and Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Richard&nbsp;F. Pops
  <HR size="1" noshade color="#000000">
  Richard F. Pops</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director and Chief Executive Officer<BR>
  (Principal Executive Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ James&nbsp;M. Frates
  <HR size="1" noshade color="#000000">
  James M. Frates</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Vice President, Chief Financial Officer and
  Treasurer<BR>
  (Principal Financial and Accounting Officer)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Floyd E. Bloom
  <HR size="1" noshade color="#000000">
  Floyd E. Bloom</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Robert&nbsp;A. Breyer
  <HR size="1" noshade color="#000000">
  Robert A. Breyer</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Gerri Henwood
  <HR size="1" noshade color="#000000">
  Gerri Henwood</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;</DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="25%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="45%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" nowrap valign="top">/s/ Paul&nbsp;J. Mitchell
  <HR size="1" noshade color="#000000">
  Paul J. Mitchell</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Alexander Rich
  <HR size="1" noshade color="#000000">
  Alexander Rich</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Paul Schimmel
  <HR size="1" noshade color="#000000">
  Paul Schimmel</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <TR valign="bottom" style="padding-top: 1em">
      <TD align="center" nowrap valign="top">/s/ Mark&nbsp;B. Skaletsky
  <HR size="1" noshade color="#000000">
  Mark B. Skaletsky</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">
  Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">April 22, 2005</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;</DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "INDEX TO EXHIBITS" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <P align="center" style="font-size: 10pt"><B>INDEX TO EXHIBITS</B>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="10%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="85%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left"><U>Exhibit No.</U></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><U>Description of Exhibit</U></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen of Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4 to the Registrant&#146;s
  Registration Statement on Form&nbsp;S-1, as amended (File No.
  33-40250).)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen of Non-Voting Common Stock Certificate of Alkermes,
  Inc. (filed herewith).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit&nbsp;4.1 to the Registrant&#146;s
  Report on Form&nbsp;8-K filed on December&nbsp;13, 2002.)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Indenture, dated as of February&nbsp;18, 2000, between Alkermes,
  Inc. and State Street Bank and Trust Company, as Trustee.
  (3.75% Subordinated Notes) (Incorporated by reference to
  Exhibit&nbsp;4.6 to the Registrant&#146;s Registration Statement on Form
  S-3, as amended filed on February&nbsp;29, 2000 (File No.
  333-31354).)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of 3.75% Subordinated Note (Incorporated by reference to
  Exhibit&nbsp;4.6 to the Registrant&#146;s Registration Statement on Form
  S-3, as amended filed on February&nbsp;29, 2000 (File No.
  333-31354).)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.6
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Rights Agreement, dated as of February&nbsp;7, 2003, as amended,
  between Alkermes, Inc. and EquiServe Trust Co., N.A., as
  Rights Agent. (Incorporated by reference to Exhibit&nbsp;4.1 to the
  Registrant&#146;s Report on Form&nbsp;8-A filed on May&nbsp;2, 2003.)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.7
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Indenture, dated August&nbsp;22, 2003, between Alkermes, Inc. and
  U.S. Bank National Association, as Trustee (2<FONT style="font-size: 70%"><SUP>1</SUP></FONT>/<FONT style="font-size: 60%">2</FONT>% Subordinated
  Notes.) (Incorporated by reference to Exhibit&nbsp;4.7 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended
  filed on September&nbsp;3, 2003 (File No.&nbsp;333-108483).)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.8
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of 2<FONT style="font-size: 70%"><SUP>1</SUP></FONT>/<FONT style="font-size: 60%">2</FONT>% Subordinated Note (Incorporated by reference to
  Exhibit&nbsp;4.7 to the Registrant&#146;s Registration Statement on Form
  S-1, as amended filed on September&nbsp;3, 2003 (File No.
  333-108483).)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.9
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Indenture, dated February&nbsp;1, 2005, between RC Royalty Sub LLC
  and U.S. Bank National Association, as Trustee (Risperdal
  Consta &#174; PhaRMA <SUP style="font-size: 85%; vertical-align: text-top">(SM)</SUP> secured 7% Notes due 2018,
  Class&nbsp;A). (Incorporated by reference to Exhibit&nbsp;4.1 to
  Registrant&#146;s Report on Form&nbsp;8-K filed on February&nbsp;3, 2005)
  (File No.&nbsp;001-14131).)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.10
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Risperdal Consta &#174; PhaRMA <SUP style="font-size: 85%; vertical-align: text-top">(SM)</SUP> secured 7%
  Notes due 2018, Class&nbsp;A (Incorporated by reference to Exhibit
  A to Exhibit&nbsp;4.1 to the Registrant&#146;s Report on Form&nbsp;8-K filed
  on February&nbsp;3, 2005) (File No.&nbsp;001-14131).)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">&nbsp;</DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="10%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="85%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.11
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Alkermes, Inc. 1999 Stock Option Plan, as amended
  (Incorporated by reference to Exhibit&nbsp;10.1 to the Registrant&#146;s
  Report on Form&nbsp;10-Q for the quarter ended September&nbsp;30, 2004)
  (File No.&nbsp;001-14131).)</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Goodwin Procter LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Goodwin Procter LLP (included in Exhibit&nbsp;5.1).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Ernst &#038; Young LLP (filed herewith).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included in signature page).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  
  </BODY>
  </HTML>
metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "b54748aksv8.htm", "description": "ALKERMES, INC.", "secsgml_size_bytes": 46947}]
metadata_filer: {"company-data": {"conformed-name": "ALKERMES INC", "cik": "0000874663", "assigned-sic": "2834", "irs-number": "232472830", "state-of-incorporation": "PA", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-124269", "film-number": "05768213"}, "business-address": {"street1": "88 SIDNEY ST", "city": "CAMBRIDGE", "state": "MA", "zip": "02139-4136", "phone": "617-494-0171"}}
text: Alkermes, Inc.
  Table of Contents
  As filed with the Securities and Exchange Commission on April 22, 2005
  Registration No. 333-______
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT UNDER
  THE SECURITIES ACT OF 1933
  Alkermes, Inc.
  (Exact Name of Registrant as specified in its charter)
  Pennsylvania
  23-2472830
  (State or other jurisdiction of incorporation or
  (I.R.S. Employer Identification No.)
  organization)
  ALKERMES, INC.
  88 SIDNEY STREET
  CAMBRIDGE, MASSACHUSETTS 02139-4234
  TELEPHONE: (617) 494-0171
  (Address, including zip code, and telephone number, including area code,
  of registrant's principal executive offices)
  ALKERMES, INC. 1999 STOCK OPTION PLAN
  (Full title of the plan)
  Richard F. Pops
  Chief Executive Officer
  ALKERMES, INC.
  88 Sidney Street
  Cambridge, Massachusetts 02139-4234
  Telephone: (617) 494-0171
  (Name, address, including zip code, and telephone number, including area code,
  of agent for service)
  Copies to:
  Mitchell S. Bloom, Esq.
  Kathryn L. Biberstein, Esq.
  Goodwin Procter LLP
  Alkermes, Inc.
  53 State Street
  88 Sidney Street
  Boston, MA 02109
  Cambridge, MA 02139
  Telephone: (617) 570-1055
  Telephone: (617) 583-6255
  Table of Contents
  CALCULATION OF REGISTRATION FEE
  Proposed
  Maximum
  Proposed
  Offering
  Maximum
  Title of Securities
  Amount to be
  Price Per
  Aggregate
  Amount of
  to be Registered
  Registered
  (1)(4)
  Share
  Offering Price
  Registration Fee
  Common Stock, par value $.01 per share
  1,058,676
  (2)
  $
  14.90
  $
  15,774,272.40
  $
  1,856.63
  250
  (2)
  $
  14.89
  $
  3,722.50
  $
  0.44
  6,500
  (2)
  $
  13.12
  $
  85,280.00
  $
  10.04
  6,500
  (2)
  $
  12.63
  $
  82,095.00
  $
  9.66
  750
  (2)
  $
  12.75
  $
  9,562.50
  $
  1.13
  2,500
  (2)
  $
  12.73
  $
  31,825.00
  $
  3.75
  500
  (2)
  $
  11.54
  $
  5,770.00
  $
  0.68
  80,000
  (2)
  $
  11.63
  $
  930,400.00
  $
  109.51
  6,750
  (2)
  $
  11.20
  $
  75,600.00
  $
  8.90
  1,000
  (2)
  $
  10.63
  $
  10,630.00
  $
  1.25
  6,000
  (2)
  $
  10.25
  $
  61,500.00
  $
  7.24
  10,000
  (2)
  $
  10.60
  $
  106,000.00
  $
  12.48
  1,000
  (2)
  $
  11.03
  $
  11,030.00
  $
  1.30
  1,319,574
  $
  11.67
  (3)
  $
  15,399,428.58
  $
  1,812.51
  TOTALS:
  2,500,000
  $
  32,587,115.98
  $
  3,835.50
  (1)
  Pursuant to Rule 416 under the Securities Act of 1933, this registration statement shall
  also be deemed to cover an indeterminate number of additional shares of Common Stock issuable
  in the event the number of outstanding shares of the Company is increased by split-up,
  reclassification, stock dividend, recapitalization, and certain other capital adjustments and
  the like.
  (2)
  Such shares are issuable upon the exercise of outstanding options with fixed exercise prices.
  Pursuant to Rule 457(h), the aggregate offering price and fee have been computed upon the
  basis of the price at which such options may be exercised. The offering price per share set
  forth for such shares is the exercise price per share at which such options are exercisable.
  (3)
  Estimated solely for the purpose of calculating the registration fee. In accordance with
  Rules 457 (c) and 457(h), the proposed maximum offering price per share, the proposed maximum
  aggregate offering price, and the registration fee shown has been computed based upon the
  average of the high and low price of the Company's Common Stock on April 20, 2005, $11.67, as
  reported on the Nasdaq National Market with respect to securities for which options have not
  been granted.
  (4)
  This registration statement relates 2,500,000 shares of Common Stock, $.01 par value per
  share, reserved for issuance under the 1999 Stock Option Plan (the "1999 Plan"), which shares
  are in addition to 14,400,000 shares of Common Stock, $.01 par value per share, previously
  registered pursuant to Registration Statements on Form S-8 (Registration Nos. 333-89573,
  333-48772, 333-72988, 333-107206 and 333-109376) and filed with the Securities and Exchange
  Commission. The current filing is being made to register the 2,500,000 shares which are
  issuable under the 1999 Plan.
  -2-
  TABLE OF CONTENTS
  PART I
  PART II
  Item 3.
  Incorporation of Documents by Reference
  .
  Item 4.
  Description of Securities.
  Item 5.
  Interests of Named Experts and Counsel.
  Item 8.
  Exhibits
  .
  SIGNATURES
  INDEX TO EXHIBITS
  Ex-4.2 Specimen of Non-Voting Common Stock Certificate
  Ex-5.1 Opinion of Goodwin Proctor LLP
  Ex-23.2 Consent of Deloitte & Touche LLP
  Ex-23.3 Consent of Ernst & Young LLP
  Table of Contents
  PART I
  Part I and Items 6, 7 and 9 of Part II of Alkermes, Inc.'s Registration Statement on Form S-8
  (File No. 333-89573) are incorporated by reference herein pursuant to Instruction E of Form S-8.
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3.
  Incorporation of Documents by Reference
  .
  The following documents filed with the Securities and Exchange Commission (the "Commission")
  pursuant to the Securities Exchange Act of 1934 (the "Exchange Act") by Alkermes, Inc. (the
  "Company") (File No. 1-14131) or pursuant to the Securities Act of 1933, as amended (the
  "Securities Act") are incorporated herein by reference:
  (a)
  Annual Report on Form 10-K for the fiscal year ended March 31, 2004;
  (b)
  Quarterly Reports on Form 10-Q for the periods ended June 30, 2004, September 30, 2004 and
  December 31, 2004;
  (c)
  All other documents filed by the Company pursuant to 13(a) or 15(d) of the Exchange Act since
  the end of the fiscal year covered by the document referred to in (a) above; and
  (d)
  Item 1 of Registration Statement of the Company on Form 8-A dated June 28, 1991, as amended
  by a Registration Statement of the Company on Form 8-A/A dated January 17, 1997; and Item 1 of
  Registration Statement of the Company on Form 8-A dated May 2, 2003.
  All documents filed by the Company pursuant to Sections 13(a), 13(c), 14 or 15(d) of the
  Exchange Act, after the date of this Registration Statement and prior to the filing of a
  post-effective amendment which indicates that all securities offered herein have been sold or which
  deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference
  herein and to be part hereof from the date of filing such documents. Any statement contained herein
  or in a document incorporated by reference or deemed to be incorporated by reference herein shall
  be deemed to be modified or superseded for purposes of this Registration Statement to the extent
  that such statement is modified or superseded by any other subsequently filed document which is
  incorporated or is deemed to be incorporated by reference herein. Any such statement so modified or
  superseded shall not be deemed, except as so modified or superseded, to constitute a part of this
  Registration Statement.
  Item 4.
  Description of Securities.
  Not Applicable
  Item 5.
  Interests of Named Experts and Counsel.
  Not Applicable.
  Item 8.
  Exhibits
  .
  Reference is made to the Exhibit Index.
  -3-
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the City of Cambridge, in the Commonwealth of Massachusetts, on this
  22nd day of April, 2005.
  ALKERMES, INC.
  By:
  /s/
  Richard F. Pops
  Richard F. Pops
  Chief Executive Officer
  POWER OF ATTORNEY AND SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed below by the following persons in the capacities and on the dates indicated.
  Each person whose signature appears below in so signing also makes, constitutes and appoints
  Richard F. Pops and James M. Frates, and each of them, his true and lawful attorney-in-fact, with
  full power of substitution, for him in any and all capacities, to execute and cause to be filed
  with the Securities and Exchange Commission any and all amendments and post-effective amendments to
  this Registration Statement, with exhibits thereto and other documents in connection therewith, and
  hereby ratifies and confirms all that said attorney-in-fact or his substitute or substitutes may do
  or cause to be done by virtue hereof.
  SIGNATURE
  TITLE
  DATE
  /s/ Michael A. Wall
  Michael A. Wall
  Director and Chairman of the Board
  April 22, 2005
  /s/ Richard F. Pops
  Richard F. Pops
  Director and Chief Executive Officer
  (Principal Executive Officer)
  April 22, 2005
  /s/ James M. Frates
  James M. Frates
  Vice President, Chief Financial Officer and
  Treasurer
  (Principal Financial and Accounting Officer)
  April 22, 2005
  /s/ Floyd E. Bloom
  Floyd E. Bloom
  Director
  April 22, 2005
  /s/ Robert A. Breyer
  Robert A. Breyer
  Director
  April 22, 2005
  /s/ Gerri Henwood
  Gerri Henwood
  Director
  April 22, 2005
  Table of Contents
  /s/ Paul J. Mitchell
  Paul J. Mitchell
  Director
  April 22, 2005
  /s/ Alexander Rich
  Alexander Rich
  Director
  April 22, 2005
  /s/ Paul Schimmel
  Paul Schimmel
  Director
  April 22, 2005
  /s/ Mark B. Skaletsky
  Mark B. Skaletsky
  Director
  April 22, 2005
  Table of Contents
  INDEX TO EXHIBITS
  Exhibit No.
  Description of Exhibit
  4.1
  Specimen of Common Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4 to the Registrant's
  Registration Statement on Form S-1, as amended (File No.
  33-40250).)
  4.2
  Specimen of Non-Voting Common Stock Certificate of Alkermes,
  Inc. (filed herewith).
  4.3
  Specimen of 2002 Preferred Stock Certificate of Alkermes, Inc.
  (Incorporated by reference to Exhibit 4.1 to the Registrant's
  Report on Form 8-K filed on December 13, 2002.)
  4.4
  Indenture, dated as of February 18, 2000, between Alkermes,
  Inc. and State Street Bank and Trust Company, as Trustee.
  (3.75% Subordinated Notes) (Incorporated by reference to
  Exhibit 4.6 to the Registrant's Registration Statement on Form
  S-3, as amended filed on February 29, 2000 (File No.
  333-31354).)
  4.5
  Form of 3.75% Subordinated Note (Incorporated by reference to
  Exhibit 4.6 to the Registrant's Registration Statement on Form
  S-3, as amended filed on February 29, 2000 (File No.
  333-31354).)
  4.6
  Rights Agreement, dated as of February 7, 2003, as amended,
  between Alkermes, Inc. and EquiServe Trust Co., N.A., as
  Rights Agent. (Incorporated by reference to Exhibit 4.1 to the
  Registrant's Report on Form 8-A filed on May 2, 2003.)
  4.7
  Indenture, dated August 22, 2003, between Alkermes, Inc. and
  U.S. Bank National Association, as Trustee (2
  1
  /
  2
  % Subordinated
  Notes.) (Incorporated by reference to Exhibit 4.7 to the
  Registrant's Registration Statement on Form S-1, as amended
  filed on September 3, 2003 (File No. 333-108483).)
  4.8
  Form of 2
  1
  /
  2
  % Subordinated Note (Incorporated by reference to
  Exhibit 4.7 to the Registrant's Registration Statement on Form
  S-1, as amended filed on September 3, 2003 (File No.
  333-108483).)
  4.9
  Indenture, dated February 1, 2005, between RC Royalty Sub LLC
  and U.S. Bank National Association, as Trustee (Risperdal
  Consta ® PhaRMA
  (SM)
  secured 7% Notes due 2018,
  Class A). (Incorporated by reference to Exhibit 4.1 to
  Registrant's Report on Form 8-K filed on February 3, 2005)
  (File No. 001-14131).)
  4.10
  Form of Risperdal Consta ® PhaRMA
  (SM)
  secured 7%
  Notes due 2018, Class A (Incorporated by reference to Exhibit
  A to Exhibit 4.1 to the Registrant's Report on Form 8-K filed
  on February 3, 2005) (File No. 001-14131).)
  Table of Contents
  4.11
  Alkermes, Inc. 1999 Stock Option Plan, as amended
  (Incorporated by reference to Exhibit 10.1 to the Registrant's
  Report on Form 10-Q for the quarter ended September 30, 2004)
  (File No. 001-14131).)
  5.1
  Opinion of Goodwin Procter LLP (filed herewith).
  23.1
  Consent of Goodwin Procter LLP (included in Exhibit 5.1).
  23.2
  Consent of Deloitte & Touche LLP (filed herewith).
  23.3
  Consent of Ernst & Young LLP (filed herewith).
  24.1
  Power of Attorney (included in signature page).