content: <HTML>
  <HEAD>
  <TITLE>sv8</TITLE>
  </HEAD>
  <BODY bgcolor="#FFFFFF">
  <!-- PAGEBREAK -->
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">Registration No.&nbsp;333-
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT<BR>
  UNDER<BR>
  THE SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>CLINICAL DATA, INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(Exact name of Registrant as specified in its charter)</DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-2573920</B></TD>
  </TR>
  <TR style="font-size: 1px">
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(State or Other Jurisdiction
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(I.R.S. Employer Identification</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">of Incorporation or
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Number)</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">Organization)</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>One Gateway Center, Suite&nbsp;411<BR>
  Newton, MA 02458<BR>
  (617)&nbsp;527-9933</B></DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 1pt; width: 50%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt">(Address of Principal Executive Offices, including Zip<br>
  Code and Telephone Number)</DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>2005 Equity Incentive Plan</B></DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 1pt; width: 50%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt">(Full Title of the Plan)</DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Israel M. Stein, M.D.<BR>
  President and Chief Executive Officer<BR>
  Clinical Data, Inc.<BR>
  One Gateway Center, Suite&nbsp;411<BR>
  Newton, MA 02458<BR>
  (617)&nbsp;527-9933</B></DIV>
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 1pt; width: 50%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt">(Name, Address, including Zip Code, and Telephone Number,<br>
  including Area Code,<br>
  of Agent for Service)</DIV>
  
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 50%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt">(with a copy to)<br>
  John Hession<br>
  Marc Recht<br>
  McDermott Will &#038; Emery LLP<br>
  28 State Street<br>
  Boston, MA 02109<br>
  (617)&nbsp;535-4000</DIV>
  
  
  <DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CALCULATION OF REGISTRATION FEE</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="33%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="22%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="6%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="6%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-bottom: 3px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Proposed Maximum</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Proposed Maximum</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Amount of</B></TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 0px solid #000000"><B>Amount to be</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Offering Price</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Aggregate Offering</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Registration</B></TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center"><B>Title of Securities to be Registered</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" colspan="1"><B>Registered(1)</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Per Share(2)</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Price(2)</B></TD>
      <TD style="border-right: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center"><B>Fee</B></TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par
  value $0.01 per share</DIV></TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 1px solid #000000">1,000,000 shares</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 1px solid #000000">$19.45</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 1px solid #000000">$19,450,000</TD>
      <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
      <TD style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 1px solid #000000">$2,290</TD>
      <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-top: 3px solid #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left">
  <DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV>
  
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>Plus, pursuant to Rule 416(a) under the Securities Act, such additional number of shares as
  may be required in the event of a stock dividend, split-up of shares or other similar change
  in the Common Stock.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>Estimated solely for the purpose of computing the amount of the registration fee under Rules
  457(c) and 457(h)(1) based on the average of the high and low price per share of the
  Registrant&#146;s Common Stock on the NASDAQ Capital Market on November&nbsp;9, 2005.</TD>
  </TR>
  
  </TABLE>
  
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt">&nbsp;
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  <!-- link1 " PART I" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The information required by Part&nbsp;I is included in the documents sent or given to participants
  in the 2005 Equity Incentive Plan of Clinical Data, Inc. (the &#147;<U><I>Registrant</I></U>&#148;) pursuant to
  Rule&nbsp;428(b)(1) of the Securities Act of 1933, as amended (the &#147;<U><I>Securities Act</I></U>&#148;).
  </DIV>
  <!-- link1 " PART II" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  </DIV>
  
  <!-- link2 "Item&nbsp;3. Incorporation of Documents By Reference" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;3. Incorporation of Documents By Reference.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Securities and Exchange Commission
  (the &#147;<U><I>Commission</I></U>&#148;), pursuant to the Securities Exchange Act of 1934, as amended (the
  &#147;<U><I>Exchange Act</I></U>&#148;), are incorporated by reference herein and shall be deemed as part hereof:
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>the Registrant&#146;s Annual Report on Form 10-KSB for the fiscal year ended March
  31, 2005;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>the Registrant&#146;s Quarterly Report on Form 10-Q for the quarter ended June&nbsp;30,
  2005;</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>the Registrant&#146;s Current Reports on Form 8-K, filed on April&nbsp;21, 2005, June&nbsp;21,
  2005, June&nbsp;24, 2005, July&nbsp;11, 2005, August&nbsp;2, 2005, September&nbsp;20, 2005, September&nbsp;22,
  2005, September&nbsp;28, 2005, October&nbsp;11, 2005 (as amended on November&nbsp;9, 2005), October
  21, 2005 and November&nbsp;1, 2005 (as to Item&nbsp;8.01 only); and</TD>
  </TR>
  
  <TR>
      <TD style="font-size: 6pt">&nbsp;</TD>
  </TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="2%" style="background: transparent">&nbsp;</TD>
      <TD width="3%" nowrap align="left">(d)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>the description of the Registrant&#146;s Common Stock, par value $0.01 per share,
  contained in the Section entitled &#147;Description of Clinical Data Capital Stock &#150;
  Clinical Data Common Stock&#148;, incorporated by reference from the Registrant&#146;s Proxy
  Statement/Prospectus filed with the Commission on October&nbsp;27, 2005, including any
  amendment or report filed hereafter for the purpose of updating such description.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents subsequently filed by the Registrant pursuant to Sections&nbsp;13(a), 13(c), 14 and
  15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that
  all securities offered have been sold or which deregisters all securities then remaining unsold,
  shall be deemed to be incorporated by reference herein and to be a part hereof from the date of
  filing of such documents.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any statement contained in a document incorporated or deemed to be incorporated by reference
  herein shall be deemed to be modified or superseded for purposes of this Registration Statement to
  the extent that a statement contained herein or in any other subsequently filed document which also
  is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any
  such statement so modified or superseded shall not be deemed, except as so modified or superseded,
  to constitute a part of this Registration Statement.
  </DIV>
  <!-- link2 " Item&nbsp;4. Description of Securities" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;4. Description of Securities.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 " Item&nbsp;5. Interests of Named Experts and Counsel" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 " Item&nbsp;6. Indemnification of Directors and Officers" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant&#146;s certificate of incorporation provides that the Registrant shall, to the
  fullest extent permitted by Section&nbsp;145 of the Delaware General Corporation Law, indemnify any and
  all directors and officers which it shall have the power to indemnify from and against any and all
  of the expenses, liabilities or other matters
  </DIV>
  
  <P align="center" style="font-size: 10pt">-1-
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">referred to in or covered by Section&nbsp;145 of the Delaware General Corporation Law. The
  Registrant&#146;s certificate of incorporation also provides that such indemnification rights shall not
  be exclusive of any other rights to which those seeking indemnification may be entitled under any
  bylaw, agreement, vote of its stockholders or disinterested directors or otherwise. The
  Registrant&#146;s certificate of incorporation additionally provides that, to the fullest extent
  permitted by Delaware law, a director of the Registrant shall not be liable to the Registrant or
  its stockholders for monetary damages for breach of fiduciary duty as a director.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant&#146;s amended and restated bylaws provide that the Registrant shall, to the fullest
  extent authorized by the General Corporation Law of the state of Delaware, indemnify any person who
  was or is a party or is threatened to be made a party to or is otherwise involved in any
  threatened, pending or completed action, suit or proceeding, whether civil, criminal,
  administrative, investigative or otherwise, and whether by or in the right of the Registrant, its
  stockholders, a third party or otherwise, by reason of the fact that such person is or was a
  director or officer of the Registrant, or is or was serving at the request of the Registrant as a
  director, officer, employee or agent of another corporation, partnership, joint venture, trust or
  other enterprise, including, without limitation, a charity or a non-profit organization or person,
  against all expenses (including, but not limited to attorneys&#146; fees), liability, loss, judgments,
  fines, excise taxes, penalties and amounts paid in settlement actually and reasonably incurred by
  such person in connection with such action, suit or proceeding, including expenses incurred in
  seeking indemnification. No indemnification is available with respect to: (i)&nbsp;indemnification of
  any improper personal benefit which a director or officer is determined to have received and of the
  expenses of defending against an improper personal benefit claim unless the director or officer is
  successful on the merits in said defense, and (ii)&nbsp;indemnification of present or former officers,
  directors, employees or agents of a constituent corporation absorbed in a merger or consolidation
  transaction with the Registrant with respect to their activities prior to said transaction, unless
  specifically authorized by the Registrant&#146;s board of directors or stockholders. The Registrant&#146;s
  bylaws also provide that such indemnification rights shall not be exclusive of other
  indemnification rights to which those seeking indemnification may be entitled by law or under any
  bylaw, agreement, vote of its stockholders or directors or otherwise.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant has entered into indemnification agreements with each of its current directors
  and officers, pursuant to which the Registrant agreed to indemnify each director and officer with
  respect to any expenses, judgments, fines, penalties, and amounts paid in settlement in connection
  with any claim, pending or completed action, suit or proceeding, or any inquiry or investigation,
  related to any actions taken by the director or officer related to their service to the Registrant
  as a director or officer.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant maintains insurance on behalf of any person who is a director or officer
  against any loss arising from any claim asserted against him or her and incurred by him or her in
  any such capacity, subject to certain exclusions.
  </DIV>
  <!-- link2 "Item&nbsp;7. Exemption from Registration Claimed" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;7. Exemption from Registration Claimed.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8. Exhibits.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Exhibit&nbsp;Index immediately following the signature pages is incorporated by reference herein.
  </DIV>
  <!-- link2 "Item&nbsp;9. Undertakings" -->
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;9. Undertakings.</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The undersigned Registrant hereby undertakes:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 3%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made, a
  post-effective amendment to this registration statement:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 3%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act of
  1933;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 3%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date
  of this registration statement (or the most recent post-effective amendment thereof) which,
  individually or in the aggregate, represent a fundamental change in the information set
  forth in the registration statement. Notwithstanding the foregoing, any increase or
  decrease in volume of securities offered (if the total dollar
  </DIV>
  
  <P align="center" style="font-size: 10pt">-2-
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 3%">value of securities offered would not exceed that which was registered) and any
  deviation from the low or high end of the estimated maximum offering range may be reflected
  in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
  aggregate, the changes in volume and price represent no more than a 20&nbsp;percent change in the
  maximum aggregate offering price set forth in the &#147;Calculation of Registration Fee&#148; table in
  the registration statement;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 3%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution not
  previously disclosed in the registration statement or any material change to such
  information in the registration statement.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 3%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided</I>, <I>however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  registration statement is on Form S-3, Form S-8 or Form F-3, and the information required to
  be included in a post-effective amendment by those paragraphs is contained in periodic
  reports filed with or furnished to the Commission by the registrant pursuant to Section&nbsp;13
  or 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the
  registration statement.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 3%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act of
  1933, each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 3%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the offering.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;The undersigned Registrant hereby undertakes that, for purposes of determining any
  liability under the Securities Act of 1933, each filing of the Registrant&#146;s annual report pursuant
  to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable,
  each filing of an employee benefit plan&#146;s annual report pursuant to Section 15(d) of the Securities
  Exchange Act of 1934) that is incorporated by reference in the registration statement shall be
  deemed to be a new registration statement relating to the securities offered therein, and the
  offering of such securities at that time shall be deemed to be the initial bona fide offering
  thereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h)&nbsp;Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed in
  the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for
  indemnification against such liabilities (other than the payment by the Registrant of expenses
  incurred or paid by a director, officer or controlling person of the Registrant in the successful
  defense of any action, suit or proceeding) is asserted by such director, officer or controlling
  person in connection with the securities being registered, the Registrant will, unless in the
  opinion of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public policy
  as expressed in the Act and will be governed by the final adjudication of such issue.
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">-3-
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link1 " SIGNATURES" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies
  that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the Town of Smithfield, State of Rhode Island, on November&nbsp;10, 2005.
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="48%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="13%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="3" valign="top" align="left">CLINICAL DATA, INC.</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By:
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">/s/ Israel M. Stein</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Israel M. Stein, M.D.</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><I>President and Chief Executive Officer</I></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><I>Principal Executive Officer</I></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">By:
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">/s/ Mark D. Shooman</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">Mark D. Shooman</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top" nowrap><I>Senior Vice President and Chief Financial Officer</I></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><I>Principal Financial and Accounting Officer</I></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below hereby constitutes and appoints Israel M. Stein,
  M.D. and Caesar J. Belbel or either of them, his true and lawful attorneys and agent, with full
  power of substitution, and with power to act alone, to sign on behalf of the undersigned any
  amendment or amendments to this registration statement on Form S-8 (including pre- and
  post-effective amendments) and to perform any acts necessary to file such amendments, with exhibits
  thereto and other documents in connection therewith, and each of the undersigned does hereby ratify
  and confirm his signature as it may be signed by his said attorneys and agents to any and all such
  documents and all that said attorneys and agents, or their substitutes, shall do or cause to be
  done by virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this registration statement has
  been signed by the following persons in the capacities and as of the dates indicated.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="28%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="40%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"> <B>Signature</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ RANDAL J. KIRK
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Randal J. Kirk
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chairman of the Board
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>November&nbsp;10, 2005</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ ISRAEL M. STEIN
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Israel M. Stein, M.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">President, Chief Executive
  Officer and Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>November&nbsp;10, 2005</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">(Principal Executive Officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ LARRY D. HORNER
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Larry D. Horner
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>November&nbsp;10, 2005</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ ARTHUR B. MALMAN
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Arthur B. Malman
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>November&nbsp;10, 2005</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ BURTON SOBEL
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Burton Sobel
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>November&nbsp;10, 2005</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ JOSEPH KLEIN III
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Joseph Klein III
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>November&nbsp;10, 2005</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ KEVIN RAKIN
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Kevin Rakin
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><B>November&nbsp;10, 2005</B></TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <P align="center" style="font-size: 10pt">II-1
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <!-- link1 " EXHIBIT INDEX" -->
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXHIBIT INDEX</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="8%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="87%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Exhibit No.</B></TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">4.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Incorporation. Filed as Exhibit&nbsp;3.1 to Clinical Data&#146;s
  Registration Statement on Form&nbsp;S-1 (File No.&nbsp;2-82494) filed on March&nbsp;17, 1983,
  and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">4.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment of Certificate of Incorporation. Filed as Exhibit&nbsp;3.1
  to Clinical Data&#146;s Quarterly Report on Form&nbsp;10-QSB (File No.&nbsp;000-12716) filed on
  February&nbsp;17, 2004, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">4.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Certificate of Amendment to Certificate of Incorporation Filed as Exhibit&nbsp;3.1 to
  Clinical Data&#146;s Current Report on Form&nbsp;8-K (File No.&nbsp;000-12716) filed on October
  11, 2005, and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">4.4
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated Bylaws of Clinical Data. Filed as Exhibit&nbsp;3.1 to Clinical
  Data&#146;s Current Report on Form&nbsp;8-K (File No.&nbsp;000-12716) filed on June&nbsp;24, 2005,
  and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">4.5
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">2005 Equity Incentive Plan. Filed as Exhibit&nbsp;99.1 to Clinical Data&#146;s Current
  Report on Form&nbsp;8-K (File No.&nbsp;000-12716) filed on October&nbsp;11, 2005 and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">5.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of McDermott Will &#038; Emery LLP as to the validity of the common stock of
  Clinical Data being registered hereby, together with consent.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">23.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP, Clinical Data&#146;s independent registered public
  accounting firm.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">23.2
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of PricewaterhouseCoopers, LLP, Genaissance&#146;s independent registered
  public accounting firm.</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">23.3
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of McDermott Will &#038; Emery LLP (included in Exhibit&nbsp;5.1).</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:18px; text-indent:-0px">24.1
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney (included in the signature page of this registration statement).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt">II-2
  </DIV>
  
  </BODY>
  </HTML>
metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "b57791epsv8.htm", "description": "CLINICAL DATA, INC.", "secsgml_size_bytes": 45191}]
metadata_filer: {"company-data": {"conformed-name": "CLINICAL DATA INC", "cik": "0000716646", "assigned-sic": "3826", "irs-number": "042573920", "state-of-incorporation": "DE", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-129634", "film-number": "051194431"}, "business-address": {"street1": "ONE GATEWAY CENTER", "street2": "SUITE 411", "city": "NEWTON", "state": "MA", "zip": "02158", "phone": "6172619933"}, "mail-address": {"street1": "ONE GATEWAY CENTER", "street2": "SUITE 411", "city": "NEWTON", "state": "MA", "zip": "02158"}, "former-company": [{"former-conformed-name": "NOVITRON INTERNATIONAL INC", "date-changed": "19940727"}, {"former-conformed-name": "CLINICAL DATA INC", "date-changed": "19920703"}]}
text: sv8
  Registration No. 333-
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  UNDER
  THE SECURITIES ACT OF 1933
  CLINICAL DATA, INC.
  (Exact name of Registrant as specified in its charter)
  Delaware
  04-2573920
  (State or Other Jurisdiction
  (I.R.S. Employer Identification
  of Incorporation or
  Number)
  Organization)
  One Gateway Center, Suite 411
  Newton, MA 02458
  (617) 527-9933
  (Address of Principal Executive Offices, including Zip
  Code and Telephone Number)
  2005 Equity Incentive Plan
  (Full Title of the Plan)
  Israel M. Stein, M.D.
  President and Chief Executive Officer
  Clinical Data, Inc.
  One Gateway Center, Suite 411
  Newton, MA 02458
  (617) 527-9933
  (Name, Address, including Zip Code, and Telephone Number,
  including Area Code,
  of Agent for Service)
  (with a copy to)
  John Hession
  Marc Recht
  McDermott Will & Emery LLP
  28 State Street
  Boston, MA 02109
  (617) 535-4000
  CALCULATION OF REGISTRATION FEE
  Proposed Maximum
  Proposed Maximum
  Amount of
  Amount to be
  Offering Price
  Aggregate Offering
  Registration
  Title of Securities to be Registered
  Registered(1)
  Per Share(2)
  Price(2)
  Fee
  Common Stock, par
  value $0.01 per share
  1,000,000 shares
  $19.45
  $19,450,000
  $2,290
  (1)
  Plus, pursuant to Rule 416(a) under the Securities Act, such additional number of shares as
  may be required in the event of a stock dividend, split-up of shares or other similar change
  in the Common Stock.
  (2)
  Estimated solely for the purpose of computing the amount of the registration fee under Rules
  457(c) and 457(h)(1) based on the average of the high and low price per share of the
  Registrant's Common Stock on the NASDAQ Capital Market on November 9, 2005.
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  The information required by Part I is included in the documents sent or given to participants
  in the 2005 Equity Incentive Plan of Clinical Data, Inc. (the "
  Registrant
  ") pursuant to
  Rule 428(b)(1) of the Securities Act of 1933, as amended (the "
  Securities Act
  ").
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents By Reference.
  The following documents filed by the Registrant with the Securities and Exchange Commission
  (the "
  Commission
  "), pursuant to the Securities Exchange Act of 1934, as amended (the
  "
  Exchange Act
  "), are incorporated by reference herein and shall be deemed as part hereof:
  (a)
  the Registrant's Annual Report on Form 10-KSB for the fiscal year ended March
  31, 2005;
  (b)
  the Registrant's Quarterly Report on Form 10-Q for the quarter ended June 30,
  2005;
  (c)
  the Registrant's Current Reports on Form 8-K, filed on April 21, 2005, June 21,
  2005, June 24, 2005, July 11, 2005, August 2, 2005, September 20, 2005, September 22,
  2005, September 28, 2005, October 11, 2005 (as amended on November 9, 2005), October
  21, 2005 and November 1, 2005 (as to Item 8.01 only); and
  (d)
  the description of the Registrant's Common Stock, par value $0.01 per share,
  contained in the Section entitled "Description of Clinical Data Capital Stock –
  Clinical Data Common Stock", incorporated by reference from the Registrant's Proxy
  Statement/Prospectus filed with the Commission on October 27, 2005, including any
  amendment or report filed hereafter for the purpose of updating such description.
  All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and
  15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that
  all securities offered have been sold or which deregisters all securities then remaining unsold,
  shall be deemed to be incorporated by reference herein and to be a part hereof from the date of
  filing of such documents.
  Any statement contained in a document incorporated or deemed to be incorporated by reference
  herein shall be deemed to be modified or superseded for purposes of this Registration Statement to
  the extent that a statement contained herein or in any other subsequently filed document which also
  is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any
  such statement so modified or superseded shall not be deemed, except as so modified or superseded,
  to constitute a part of this Registration Statement.
  Item 4. Description of Securities.
  Not applicable.
  Item 5. Interests of Named Experts and Counsel.
  Not applicable.
  Item 6. Indemnification of Directors and Officers.
  The Registrant's certificate of incorporation provides that the Registrant shall, to the
  fullest extent permitted by Section 145 of the Delaware General Corporation Law, indemnify any and
  all directors and officers which it shall have the power to indemnify from and against any and all
  of the expenses, liabilities or other matters
  -1-
  referred to in or covered by Section 145 of the Delaware General Corporation Law. The
  Registrant's certificate of incorporation also provides that such indemnification rights shall not
  be exclusive of any other rights to which those seeking indemnification may be entitled under any
  bylaw, agreement, vote of its stockholders or disinterested directors or otherwise. The
  Registrant's certificate of incorporation additionally provides that, to the fullest extent
  permitted by Delaware law, a director of the Registrant shall not be liable to the Registrant or
  its stockholders for monetary damages for breach of fiduciary duty as a director.
  The Registrant's amended and restated bylaws provide that the Registrant shall, to the fullest
  extent authorized by the General Corporation Law of the state of Delaware, indemnify any person who
  was or is a party or is threatened to be made a party to or is otherwise involved in any
  threatened, pending or completed action, suit or proceeding, whether civil, criminal,
  administrative, investigative or otherwise, and whether by or in the right of the Registrant, its
  stockholders, a third party or otherwise, by reason of the fact that such person is or was a
  director or officer of the Registrant, or is or was serving at the request of the Registrant as a
  director, officer, employee or agent of another corporation, partnership, joint venture, trust or
  other enterprise, including, without limitation, a charity or a non-profit organization or person,
  against all expenses (including, but not limited to attorneys' fees), liability, loss, judgments,
  fines, excise taxes, penalties and amounts paid in settlement actually and reasonably incurred by
  such person in connection with such action, suit or proceeding, including expenses incurred in
  seeking indemnification. No indemnification is available with respect to: (i) indemnification of
  any improper personal benefit which a director or officer is determined to have received and of the
  expenses of defending against an improper personal benefit claim unless the director or officer is
  successful on the merits in said defense, and (ii) indemnification of present or former officers,
  directors, employees or agents of a constituent corporation absorbed in a merger or consolidation
  transaction with the Registrant with respect to their activities prior to said transaction, unless
  specifically authorized by the Registrant's board of directors or stockholders. The Registrant's
  bylaws also provide that such indemnification rights shall not be exclusive of other
  indemnification rights to which those seeking indemnification may be entitled by law or under any
  bylaw, agreement, vote of its stockholders or directors or otherwise.
  The Registrant has entered into indemnification agreements with each of its current directors
  and officers, pursuant to which the Registrant agreed to indemnify each director and officer with
  respect to any expenses, judgments, fines, penalties, and amounts paid in settlement in connection
  with any claim, pending or completed action, suit or proceeding, or any inquiry or investigation,
  related to any actions taken by the director or officer related to their service to the Registrant
  as a director or officer.
  The Registrant maintains insurance on behalf of any person who is a director or officer
  against any loss arising from any claim asserted against him or her and incurred by him or her in
  any such capacity, subject to certain exclusions.
  Item 7. Exemption from Registration Claimed.
  Not applicable.
  Item 8. Exhibits.
  The Exhibit Index immediately following the signature pages is incorporated by reference herein.
  Item 9. Undertakings.
  (a) The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made, a
  post-effective amendment to this registration statement:
  (i) To include any prospectus required by Section 10(a)(3) of the Securities Act of
  1933;
  (ii) To reflect in the prospectus any facts or events arising after the effective date
  of this registration statement (or the most recent post-effective amendment thereof) which,
  individually or in the aggregate, represent a fundamental change in the information set
  forth in the registration statement. Notwithstanding the foregoing, any increase or
  decrease in volume of securities offered (if the total dollar
  -2-
  value of securities offered would not exceed that which was registered) and any
  deviation from the low or high end of the estimated maximum offering range may be reflected
  in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
  aggregate, the changes in volume and price represent no more than a 20 percent change in the
  maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in
  the registration statement;
  (iii) To include any material information with respect to the plan of distribution not
  previously disclosed in the registration statement or any material change to such
  information in the registration statement.
  Provided
  ,
  however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  registration statement is on Form S-3, Form S-8 or Form F-3, and the information required to
  be included in a post-effective amendment by those paragraphs is contained in periodic
  reports filed with or furnished to the Commission by the registrant pursuant to Section 13
  or 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the
  registration statement.
  (2) That, for the purpose of determining any liability under the Securities Act of
  1933, each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment any of the
  securities being registered which remain unsold at the termination of the offering.
  (b) The undersigned Registrant hereby undertakes that, for purposes of determining any
  liability under the Securities Act of 1933, each filing of the Registrant's annual report pursuant
  to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable,
  each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities
  Exchange Act of 1934) that is incorporated by reference in the registration statement shall be
  deemed to be a new registration statement relating to the securities offered therein, and the
  offering of such securities at that time shall be deemed to be the initial bona fide offering
  thereof.
  (h) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed in
  the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for
  indemnification against such liabilities (other than the payment by the Registrant of expenses
  incurred or paid by a director, officer or controlling person of the Registrant in the successful
  defense of any action, suit or proceeding) is asserted by such director, officer or controlling
  person in connection with the securities being registered, the Registrant will, unless in the
  opinion of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public policy
  as expressed in the Act and will be governed by the final adjudication of such issue.
  -3-
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies
  that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
  S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in the Town of Smithfield, State of Rhode Island, on November 10, 2005.
  CLINICAL DATA, INC.
  By:
  /s/ Israel M. Stein
  Israel M. Stein, M.D.
  President and Chief Executive Officer
  Principal Executive Officer
  By:
  /s/ Mark D. Shooman
  Mark D. Shooman
  Senior Vice President and Chief Financial Officer
  Principal Financial and Accounting Officer
  POWER OF ATTORNEY
  Each person whose signature appears below hereby constitutes and appoints Israel M. Stein,
  M.D. and Caesar J. Belbel or either of them, his true and lawful attorneys and agent, with full
  power of substitution, and with power to act alone, to sign on behalf of the undersigned any
  amendment or amendments to this registration statement on Form S-8 (including pre- and
  post-effective amendments) and to perform any acts necessary to file such amendments, with exhibits
  thereto and other documents in connection therewith, and each of the undersigned does hereby ratify
  and confirm his signature as it may be signed by his said attorneys and agents to any and all such
  documents and all that said attorneys and agents, or their substitutes, shall do or cause to be
  done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this registration statement has
  been signed by the following persons in the capacities and as of the dates indicated.
  Signature
  Title
  Date
  /s/ RANDAL J. KIRK
  Randal J. Kirk
  Chairman of the Board
  November 10, 2005
  /s/ ISRAEL M. STEIN
  Israel M. Stein, M.D.
  President, Chief Executive
  Officer and Director
  November 10, 2005
  (Principal Executive Officer)
  /s/ LARRY D. HORNER
  Larry D. Horner
  Director
  November 10, 2005
  /s/ ARTHUR B. MALMAN
  Arthur B. Malman
  Director
  November 10, 2005
  /s/ BURTON SOBEL
  Burton Sobel
  Director
  November 10, 2005
  /s/ JOSEPH KLEIN III
  Joseph Klein III
  Director
  November 10, 2005
  /s/ KEVIN RAKIN
  Kevin Rakin
  Director
  November 10, 2005
  II-1
  EXHIBIT INDEX
  Exhibit No.
  Description
  4.1
  Certificate of Incorporation. Filed as Exhibit 3.1 to Clinical Data's
  Registration Statement on Form S-1 (File No. 2-82494) filed on March 17, 1983,
  and incorporated herein by reference.
  4.2
  Certificate of Amendment of Certificate of Incorporation. Filed as Exhibit 3.1
  to Clinical Data's Quarterly Report on Form 10-QSB (File No. 000-12716) filed on
  February 17, 2004, and incorporated herein by reference.
  4.3
  Certificate of Amendment to Certificate of Incorporation Filed as Exhibit 3.1 to
  Clinical Data's Current Report on Form 8-K (File No. 000-12716) filed on October
  11, 2005, and incorporated herein by reference.
  4.4
  Amended and Restated Bylaws of Clinical Data. Filed as Exhibit 3.1 to Clinical
  Data's Current Report on Form 8-K (File No. 000-12716) filed on June 24, 2005,
  and incorporated herein by reference.
  4.5
  2005 Equity Incentive Plan. Filed as Exhibit 99.1 to Clinical Data's Current
  Report on Form 8-K (File No. 000-12716) filed on October 11, 2005 and
  incorporated herein by reference.
  5.1
  Opinion of McDermott Will & Emery LLP as to the validity of the common stock of
  Clinical Data being registered hereby, together with consent.
  23.1
  Consent of Deloitte & Touche LLP, Clinical Data's independent registered public
  accounting firm.
  23.2
  Consent of PricewaterhouseCoopers, LLP, Genaissance's independent registered
  public accounting firm.
  23.3
  Consent of McDermott Will & Emery LLP (included in Exhibit 5.1).
  24.1
  Power of Attorney (included in the signature page of this registration statement).
  II-2