content: <HTML>
  <HEAD>
  <TITLE>sv8</TITLE>
  </HEAD>
  <BODY bgcolor="#FFFFFF">
  <!-- PAGEBREAK -->
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">As filed with the Securities and Exchange Commission on August&nbsp;8, 2007
  </DIV>
  
  
  <DIV align="right" style="font-size: 10pt; margin-top: 12pt">REGISTRATION NO. 333 -
  </DIV>
  
  <DIV align="left" style="font-size: 6pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  <DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
  SECURITIES AND EXCHANGE COMMISSION</B>
  </DIV>
  
  <DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
  </DIV>
  
  <DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
  </DIV>
  
  
  <DIV align="center" style="font-size: 12pt; margin-top: 0pt"><B>REGISTRATION STATEMENT<BR>
  under the<BR>
  SECURITIES ACT OF 1933</B>
  </DIV>
  
  <DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>ALTUS PHARMACEUTICALS INC.</B>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt">(<I>Exact Name of Registrant as Specified in Its Charter)</I></DIV>
  
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="47%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD align="center" valign="top"><B>Delaware</B>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><B>04-3573277</B></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top">(<I>State or Other Jurisdiction</I>
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top">(<I>I.R.S. Employer</I></TD>
  </TR>
  <TR valign="bottom">
      <TD align="center" valign="top"><I>of Incorporation or Organization</I>)
  </TD>
      <TD>&nbsp;</TD>
      <TD align="center" valign="top"><I>Identification No.</I>)</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>125 Sidney Street<BR>
  Cambridge, MA 02139</B><BR>
  (<I>Address, Including Zip Code, of Principal Executive Offices</I>)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended</B><BR>
  <I>(Full Title of the Plan)</I></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Sheldon Berkle<BR>
  President and Chief Executive Officer<BR>
  Altus Pharmaceuticals Inc.<BR>
  125 Sidney Street<BR>
  Cambridge, MA 02139</B><BR>
  (<I>Name, Address and Telephone Number, Including Area Code, of Agent For Service</I>)</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt">with copies to:</DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Jonathan L. Kravetz, Esq.<BR>
  Megan N. Gates, Esq.<BR>
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.<BR>
  One Financial Center<BR>
  Boston, Massachusetts 02111</B></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>CALCULATION OF REGISTRATION FEE</B></DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="1%">&nbsp;</TD>
      <TD width="47%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="8%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="6%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="13%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD><!-- VRule -->
      <TD width="2%">&nbsp;</TD>
      <TD width="8%">&nbsp;</TD>
  
      <TD width="1%">&nbsp;</TD>
  </TR><TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-bottom: 3px double #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Proposed</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">maximum</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">Title of</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount to be</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">offering price</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">aggregate</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">Amount of</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>
  
      <TD nowrap align="center">securities to be registered</TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">registered<SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">per share<SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">offering price<SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
      <TD style="border-right: 2px solid #000000">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">registration fee</TD>
      <TD width="1%">&nbsp;</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">Common Stock, $0.01 par value</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">634,601</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$14.29</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$9,068,448</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$278.40</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">273,450</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$9.19</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$2,513,006</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$77.15</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000"><DIV style="margin-left:30px; text-indent:-15px">Total:</DIV></TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">908,051</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD align="center" valign="bottom" style="border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
      <TD style="border-top: 2px solid #000000">&nbsp;</TD>
  
  <TD align="center" valign="bottom" style="border-top: 2px solid #000000">$355.55</TD>
      <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
  </TR>
  <TR style="font-size: 1px" valign="bottom">
      <TD nowrap align="left" colspan="15" style="border-top: 3px double #000000">&nbsp;</TD>
  </TR>
  
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  
  <DIV style="margin-top: 3pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  <TR>
      <TD width="3%"></TD>
      <TD width="1%"></TD>
      <TD width="96"></TD>
  </TR>
  <TR valign="top">
      <TD nowrap align="left">(1)</TD>
      <TD>&nbsp;</TD>
      <TD>The number of shares of Common Stock stated above consists of the aggregate number of
  shares which may be sold upon the exercise of options and the issuance of stock awards which
  have been granted and/or may hereafter be granted under the Altus Pharmaceuticals Inc. Amended
  and Restated 2002 Employee, Director and Consultant Stock Plan, as amended (the &#147;Plan&#148;). The
  maximum number of shares which may be sold upon the exercise of options or issuance of stock
  awards granted under the Plan is subject to adjustment in accordance with certain anti-dilution and other provisions of the Plan. Accordingly, pursuant to Rule&nbsp;416 under the
  Securities Act of 1933, as amended (the &#147;Securities Act&#148;), this Registration Statement covers,
  in addition to the number of shares stated above, an indeterminate number of shares which may
  be subject to grant or otherwise issuable upon the operation of any such anti-dilution and
  other provisions.</TD>
  </TR>
  
  <TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>
  
  <TR valign="top">
      <TD nowrap align="left">(2)</TD>
      <TD>&nbsp;</TD>
      <TD>This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(c) and (h)&nbsp;under the Securities Act as follows: (i)&nbsp;in the case
  of shares of Common Stock which may be purchased upon exercise of outstanding options, the fee
  is calculated on the basis of the price at which the options may be exercised; and (ii)&nbsp;in the
  case of shares of Common Stock for which options and stock awards have not yet been granted
  and the exercise or purchase price of which is therefore unknown, the fee is calculated on the
  basis of the average of the high and low sale prices per share of the Common Stock on The Nasdaq
  Global Market as of a date (August&nbsp;6, 2007) within five business days prior to filing this
  Registration Statement.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
  <DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
  
  
  
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- TOC -->
  <A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>
  
  <P><CENTER>
  <TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
  <TR>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="3%"></TD>
  	<TD width="76%"></TD>
  </TR>
  <TR><TD colspan="9"><A HREF="#000">PART I</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;1. Plan Information</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;2. Registrant Information and Employee Plan Annual Information</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#003">PART II</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;4. Description of Securities</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;5. Interests of Named Experts and Counsel</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#008">Item&nbsp;7. Exemption from Registration Claimed</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#009">Item&nbsp;8. Exhibits</A></TD></TR>
  <TR><TD></TD><TD colspan="8"><A HREF="#010">Item&nbsp;9. Undertakings</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#011">SIGNATURES</A></TD></TR>
  <TR><TD colspan="9"><A HREF="#012">INDEX OF EXHIBITS</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b66393apexv5.htm">Ex-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</A></TD></TR>
  <TR><TD colspan="9"><A HREF="b66393apexv23w2.htm">Ex-23.2 Consent of Deloitte & Touche LLP</A></TD></TR>
  </TABLE>
  </CENTER>
  <!-- /TOC -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  
  
  
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXPLANATORY NOTE</B>
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">The content of the previously filed Registration Statement on Form S-8 (File No.&nbsp;333-134421) of the
  Registrant is hereby incorporated by reference. The purpose of this Form S-8 Registration
  Statement is to reflect an increase of 908,051 shares of Common Stock authorized for issuance under
  the Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan, as amended.
  </DIV>
  
  <!-- link1 "PART I" -->
  <DIV align="left"><A NAME="000"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
  
  </DIV>
  <!-- link2 "Item&nbsp;1. Plan Information" -->
  <DIV align="left"><A NAME="001"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;1.</U> <U>Plan Information</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The information required by Item&nbsp;1 is included in documents sent or given by the Registrant to
  participants in the Plan covered by this Registration Statement pursuant to Rule&nbsp;428(b)(1) under
  the Securities Act.
  </DIV>
  <!-- link2 "Item&nbsp;2. Registrant Information and Employee Plan Annual Information" -->
  <DIV align="left"><A NAME="002"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;2.</U> <U>Registrant Information and Employee Plan Annual Information</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The written statement required by Item&nbsp;2 is included in documents sent or given by the
  Registrant to participants in the Plan covered by this Registration Statement pursuant to Rule
  428(b)(1) under the Securities Act.
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  <!-- link1 "PART II" -->
  <DIV align="left"><A NAME="003"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
  </DIV>
  
  
  <DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
  
  </DIV>
  <!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference" -->
  <DIV align="left"><A NAME="004"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;3. Incorporation of Documents by Reference</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="5%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="93%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Annual Report
  on Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 2006
  filed on March&nbsp;12, 2007, as amended by Form 10-K/A filed on March&nbsp;19, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on January&nbsp;3, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Quarterly Report on Form&nbsp;10-Q/A for the quarter ended September&nbsp;30, 2006 filed on January&nbsp;16, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on February&nbsp;1, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on February&nbsp;6, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(6)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on March&nbsp;1, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(7)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on March&nbsp;8, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(8)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on April&nbsp;5, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(9)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on April&nbsp;19, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(10)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on May&nbsp;9, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(11)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Quarterly Report on Form&nbsp;10-Q for the quarter ended March&nbsp;31, 2007 filed on May&nbsp;11, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(12)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on May&nbsp;21, 2007 (File No.&nbsp;000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(13)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on June&nbsp;11, 2007 (File No, 000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(14)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on June&nbsp;28, 2007 (File No, 000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(15)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on July&nbsp;3, 2007 (File No, 000-51711);</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(16)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Current Report on Form&nbsp;8-K filed on July&nbsp;17, 2007 (File No, 000-51711); and</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(17)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">The Registrant&#146;s Quarterly Report on Form&nbsp;10-Q for the quarter ended June&nbsp;30, 2007 filed on August&nbsp;8, 2007 (File No.&nbsp;000-51711).</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, prior to the filing of
  a post-effective amendment which indicates that all securities offered hereby have been sold or
  which deregisters all securities then remaining unsold, shall be deemed to be incorporated by
  reference herein and to be part
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-1<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">hereof from the date of filing of such reports and documents. Any statement contained in a
  document incorporated or deemed to be incorporated by reference herein shall be deemed to be
  modified or superseded for the purposes of this Registration Statement to the extent that a
  statement contained herein or in any other subsequently filed document which also is or is deemed
  to be incorporated by reference herein modifies or supersedes such statement. Any statement so
  modified or superseded shall not be deemed, except as so modified or superseded, to constitute a
  part of this Registration Statement.
  </DIV>
  <!-- link2 "Item&nbsp;4. Description of Securities" -->
  <DIV align="left"><A NAME="005"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;4. Description of Securities</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel" -->
  <DIV align="left"><A NAME="006"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;5. Interests of Named Experts and Counsel</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm, their families
  and trusts for their benefit own an aggregate of approximately 13,044 shares of Common Stock of
  the Registrant and options and warrants to purchase 1,000 shares of Common Stock of the
  Registrant.
  </DIV>
  <!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers" -->
  <DIV align="left"><A NAME="007"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;6. Indemnification of Directors and Officers</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporated herein by reference from Part&nbsp;II, Item&nbsp;15 &#147;Indemnification of Directors and
  Officers&#148; of the Registrant&#146;s Registration Statement on Form S-3 (File No.&nbsp;333-141414).
  </DIV>
  <!-- link2 "Item&nbsp;7. Exemption from Registration Claimed" -->
  <DIV align="left"><A NAME="008"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;7. Exemption from Registration Claimed</U>.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
  </DIV>
  <!-- link2 "Item&nbsp;8. Exhibits" -->
  <DIV align="left"><A NAME="009"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;8. Exhibits</U>.
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="5%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="93%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant. Filed as Exhibit&nbsp;3.1 to the
  Registrant&#146;s Annual Report on Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 2006, as
  amended (File No.&nbsp;000-51711) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated By-laws of the Registrant. Filed as Exhibit&nbsp;3.4 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Certificate. Filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.4)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated Investor Rights Agreement, dated as of May&nbsp;21, 2004. Filed as Exhibit
  4.3 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037)
  and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Adage Capital Partners, L.P. Filed as Exhibit&nbsp;4.5 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-3 (File No.&nbsp;333-141414) and incorporated herein
  by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.6)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to General Electric Capital Corporation. Filed as Exhibit&nbsp;4.7
  to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-2<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="5%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="93%">&nbsp;</TD>
  </TR>
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.7)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Oxford Finance Corporation. Filed as Exhibit&nbsp;4.8 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.8)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Cystic Fibrosis Foundation Therapeutics, Inc. Filed as
  Exhibit&nbsp;4.9 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.
  333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.9)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Transamerica Business Credit Corporation. Filed as Exhibit
  4.10 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037)
  and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.10)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Cowen and Company, LLC. Filed as Exhibit&nbsp;4.11 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.11)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Series&nbsp;B Preferred Stock Warrant, as amended, together with a schedule of warrant
  holders. Filed as Exhibit&nbsp;4.12 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as
  amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.12)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Series&nbsp;C Preferred Stock Warrant, together with a schedule of warrant holders.
  Filed as Exhibit&nbsp;4.13 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File
  No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered. Filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP. Filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(24)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney to file future amendments (set forth on the signature page of this
  Registration Statement).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan, as amended. Filed as Exhibit&nbsp;10.4 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for
  the fiscal year ended December&nbsp;31, 2006, as amended (File No.&nbsp;000-51711) and incorporated
  herein by reference.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  <!-- link2 "Item&nbsp;9. Undertakings" -->
  <DIV align="left"><A NAME="010"></A></DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Item&nbsp;9. Undertakings</U>.
  </DIV>
  
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="6%" nowrap align="left">(a)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes:</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 8%">(1)&nbsp;To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 10%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of the Securities
  Act of 1933;
  </DIV>
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-3<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental
  change in the information set forth in the Registration Statement. Notwithstanding
  the foregoing, any increase or decrease in volume of securities offered (if the
  total dollar value of securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated maximum offering range
  may be reflected in the form of prospectus filed with the Commission pursuant to
  Rule 424(b) if, in the aggregate, the changes in volume and price represent no more
  than a 20% change in the maximum aggregate offering price set forth in the
  &#147;Calculation of Registration Fee&#148; table in the effective Registration Statement.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or any material
  change to such information in the Registration Statement;
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however</I>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  information required to be included in a post-effective amendment by those paragraphs is
  contained in periodic reports filed with or furnished to the Commission by the Registrant
  pursuant to Section&nbsp;13 or Section 15(d) of the Securities Exchange Act of 1934 that are
  incorporated by reference in this Registration Statement.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">(2)&nbsp;That, for the purpose of determining any liability under the Securities Act of 1933,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">(3)&nbsp;To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(b)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant&#146;s annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by
  reference in this Registration Statement shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  
  <DIV style="margin-top: 6pt">
  <TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  <TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
      <TD width="1%" nowrap align="left">(c)</TD>
      <TD width="1%">&nbsp;</TD>
      <TD>Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed
  in the Act and is, therefore, unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense
  of any action, suit or proceeding) is asserted by such director, officer or controlling person
  in connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.</TD>
  </TR>
  
  </TABLE>
  </DIV>
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-4<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  
  <DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
  
  
  
  </TABLE>
  </DIV>
  <!-- link1 "SIGNATURES" -->
  <DIV align="left"><A NAME="011"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
  </DIV>
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Cambridge, Massachusetts on August&nbsp;8, 2007.
  </DIV>
  
  <TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
  <TR>
      <TD width="48%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="35%">&nbsp;</TD>
      <TD width="15%">&nbsp;</TD>
  </TR>
  <TR>
      <TD valign="top" align="left">&nbsp;</TD>
      <TD colspan="3" align="left"><FONT style="font-variant: SMALL-CAPS"><B>ALTUS PHARMACEUTICALS INC.</B></FONT><BR>
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD valign="top">By:&nbsp;&nbsp;</TD>
      <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Sheldon Berkle
  &nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">Sheldon Berkle&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR><TR>
      <TD align="left">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD colspan="2" align="left">President and Chief Executive Officer&nbsp;</TD>
      <TD>&nbsp;</TD>
  </TR>
  <TR>
      <TD colspan="5">&nbsp;</TD>
  </TR>
  </TABLE>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt">POWER OF ATTORNEY
  </DIV>
  
  
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Sheldon Berkle, Jonathan I.
  Lieber and Bruce A. Leicher, and each of them singly, his true and lawful attorneys-in-fact and
  agents, with full power of substitution and resubstitution in each of them singly, for him and in
  his name, place and stead, and in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement on Form S-8 of Altus Pharmaceuticals
  Inc., and to file the same, with all exhibits thereto and other documents in connection therewith,
  with the Securities and Exchange Commission, granting to the attorneys-in-fact and agents, and each
  of them, full power and authority to do and perform each and every act and thing requisite or
  necessary to be done in or about the premises, as full to all intents and purposes as he might or
  could do in person, hereby ratifying and confirming all that the attorneys-in-fact and agents or
  any of each of them or their substitute may lawfully do or cause to be done by virtue hereof.
  </DIV>
  
  <DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  </DIV>
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="31%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Signature</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Title</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Date</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Sheldon Berkle
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top" nowrap>President, Chief
  Executive Officer and Director
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Sheldon Berkle
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">(principal executive officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Jonathan I. Lieber
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top" nowrap>Vice President, Chief
  Financial Officer and Treasurer
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Jonathan I. Lieber
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">(principal financial and accounting officer)</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ John P. Richards
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  John P. Richard
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Chairman of the Board&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-5<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="31%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="30%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Signature</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Title</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Date</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Stewart Hen
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Stewart Hen
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Jonathan S. Leff
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Jonathan S. Leff
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Manuel A. Navia, Ph.D.
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Manuel A. Navia, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ David D. Pendergast, Ph. D.
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  David D. Pendergast, Ph.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Harry H. Penner, Jr.
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Harry H. Penner, Jr.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Jonathan D. Root, M.D.
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Jonathan D. Root, M.D.
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Michael S. Wyzga
  <DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
  Michael S. Wyzga
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Director&nbsp;
  </TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">August&nbsp;8, 2007</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-6<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <!-- link1 "INDEX OF EXHIBITS" -->
  <DIV align="left"><A NAME="012"></A></DIV>
  
  <DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX OF EXHIBITS</B>
  </DIV>
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="5%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="93%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant. Filed as Exhibit&nbsp;3.1 to the
  Registrant&#146;s Annual Report on Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 2006, as
  amended (File No.&nbsp;000-51711) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Restated By-laws of the Registrant. Filed as Exhibit&nbsp;3.4 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.3)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Certificate. Filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Registration
  Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.4)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Amended and Restated Investor Rights Agreement, dated as of May&nbsp;21, 2004. Filed as Exhibit
  4.3 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037)
  and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Adage Capital Partners, L.P. Filed as Exhibit&nbsp;4.5 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-3 (File No.&nbsp;333-141414) and incorporated herein
  by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.6)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to General Electric Capital Corporation. Filed as Exhibit&nbsp;4.7
  to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.7)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Oxford Finance Corporation. Filed as Exhibit&nbsp;4.8 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.8)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Cystic Fibrosis Foundation Therapeutics, Inc. Filed as
  Exhibit&nbsp;4.9 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.
  333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.9)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Transamerica Business Credit Corporation. Filed as Exhibit
  4.10 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037)
  and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.10)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Common Stock Warrant to Cowen and Company, LLC. Filed as Exhibit&nbsp;4.11 to the
  Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File No.&nbsp;333-129037) and
  incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.11)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Series&nbsp;B Preferred Stock Warrant, as amended, together with a schedule of warrant
  holders. Filed as Exhibit&nbsp;4.12 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as
  amended (File No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-7<!-- /Folio -->
  </DIV>
  
  <!-- PAGEBREAK -->
  <P><HR noshade><P>
  <H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
  
  <DIV style="font-family: 'Times New Roman',Times,serif">
  
  <DIV align="center">
  <TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
  <!-- Begin Table Head -->
  <TR valign="bottom">
      <TD width="5%">&nbsp;</TD>
      <TD width="2%">&nbsp;</TD>
      <TD width="93%">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left">Exhibit</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="center">&nbsp;</TD>
  </TR>
  <TR style="font-size: 8pt" valign="bottom">
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Number</TD>
      <TD>&nbsp;</TD>
      <TD nowrap align="left" style="border-bottom: 1px solid #000000">Description</TD>
  </TR>
  
  <!-- End Table Head -->
  <!-- Begin Table Body -->
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(4.12)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Form of Series&nbsp;C Preferred Stock Warrant, together with a schedule of warrant holders.
  Filed as Exhibit&nbsp;4.13 to the Registrant&#146;s Registration Statement on Form&nbsp;S-1, as amended (File
  No.&nbsp;333-129037) and incorporated herein by reference.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(5)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered. Filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit&nbsp;5).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(23.2)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Consent of Deloitte &#038; Touche LLP. Filed herewith.</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(24)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Power of Attorney to file future amendments (set forth on the signature page of this
  Registration Statement).</TD>
  </TR>
  <TR valign="bottom"><!-- Blank Space -->
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
      <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">(99.1)
  </DIV></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan, as amended. Filed as Exhibit&nbsp;10.4 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for
  the fiscal year ended December&nbsp;31, 2006, as amended (File No.&nbsp;000-51711) and incorporated
  herein by reference.</TD>
  </TR>
  <!-- End Table Body -->
  </TABLE>
  </DIV>
  
  
  <P align="center" style="font-size: 10pt"><!-- Folio -->II-8<!-- /Folio -->
  </DIV>
  
  </BODY>
  </HTML>
metadata_documents: [{"type": "S-8", "sequence": "1", "filename": "b66393apsv8.htm", "description": "ALTUS PHARMACEUTICALS INC.", "secsgml_size_bytes": 72009}]
metadata_filer: {"company-data": {"conformed-name": "Altus Pharmaceuticals Inc.", "cik": "0001340744", "assigned-sic": "2836", "irs-number": "043573277", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-145243", "film-number": "071036061"}, "business-address": {"street1": "125 SIDNEY STREET", "city": "CAMBRIDGE", "state": "MA", "zip": "02139", "phone": "617-299-2900"}, "mail-address": {"street1": "125 SIDNEY STREET", "city": "CAMBRIDGE", "state": "MA", "zip": "02139"}}
text: sv8
  Table of Contents
  As filed with the Securities and Exchange Commission on August 8, 2007
  REGISTRATION NO. 333 -
  UNITED STATES
  SECURITIES AND EXCHANGE COMMISSION
  WASHINGTON, D.C. 20549
  FORM S-8
  REGISTRATION STATEMENT
  under the
  SECURITIES ACT OF 1933
  ALTUS PHARMACEUTICALS INC.
  (
  Exact Name of Registrant as Specified in Its Charter)
  Delaware
  04-3573277
  (
  State or Other Jurisdiction
  (
  I.R.S. Employer
  of Incorporation or Organization
  )
  Identification No.
  )
  125 Sidney Street
  Cambridge, MA 02139
  (
  Address, Including Zip Code, of Principal Executive Offices
  )
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock Plan, as amended
  (Full Title of the Plan)
  Sheldon Berkle
  President and Chief Executive Officer
  Altus Pharmaceuticals Inc.
  125 Sidney Street
  Cambridge, MA 02139
  (
  Name, Address and Telephone Number, Including Area Code, of Agent For Service
  )
  with copies to:
  Jonathan L. Kravetz, Esq.
  Megan N. Gates, Esq.
  Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  One Financial Center
  Boston, Massachusetts 02111
  CALCULATION OF REGISTRATION FEE
  Proposed
  Proposed
  maximum
  maximum
  Title of
  Amount to be
  offering price
  aggregate
  Amount of
  securities to be registered
  registered
  (1)
  per share
  (2)
  offering price
  (2)
  registration fee
  Common Stock, $0.01 par value
  634,601
  $14.29
  $9,068,448
  $278.40
  273,450
  $9.19
  $2,513,006
  $77.15
  Total:
  908,051
  $355.55
  (1)
  The number of shares of Common Stock stated above consists of the aggregate number of
  shares which may be sold upon the exercise of options and the issuance of stock awards which
  have been granted and/or may hereafter be granted under the Altus Pharmaceuticals Inc. Amended
  and Restated 2002 Employee, Director and Consultant Stock Plan, as amended (the "Plan"). The
  maximum number of shares which may be sold upon the exercise of options or issuance of stock
  awards granted under the Plan is subject to adjustment in accordance with certain anti-dilution and other provisions of the Plan. Accordingly, pursuant to Rule 416 under the
  Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement covers,
  in addition to the number of shares stated above, an indeterminate number of shares which may
  be subject to grant or otherwise issuable upon the operation of any such anti-dilution and
  other provisions.
  (2)
  This calculation is made solely for the purpose of determining the registration fee pursuant
  to the provisions of Rule 457(c) and (h) under the Securities Act as follows: (i) in the case
  of shares of Common Stock which may be purchased upon exercise of outstanding options, the fee
  is calculated on the basis of the price at which the options may be exercised; and (ii) in the
  case of shares of Common Stock for which options and stock awards have not yet been granted
  and the exercise or purchase price of which is therefore unknown, the fee is calculated on the
  basis of the average of the high and low sale prices per share of the Common Stock on The Nasdaq
  Global Market as of a date (August 6, 2007) within five business days prior to filing this
  Registration Statement.
  TABLE OF CONTENTS
  PART I
  Item 1. Plan Information
  Item 2. Registrant Information and Employee Plan Annual Information
  PART II
  Item 3. Incorporation of Documents by Reference
  Item 4. Description of Securities
  Item 5. Interests of Named Experts and Counsel
  Item 6. Indemnification of Directors and Officers
  Item 7. Exemption from Registration Claimed
  Item 8. Exhibits
  Item 9. Undertakings
  SIGNATURES
  INDEX OF EXHIBITS
  Ex-5 Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
  Ex-23.2 Consent of Deloitte & Touche LLP
  Table of Contents
  EXPLANATORY NOTE
  The content of the previously filed Registration Statement on Form S-8 (File No. 333-134421) of the
  Registrant is hereby incorporated by reference. The purpose of this Form S-8 Registration
  Statement is to reflect an increase of 908,051 shares of Common Stock authorized for issuance under
  the Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan, as amended.
  PART I
  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
  Item 1.
  Plan Information
  .
  The information required by Item 1 is included in documents sent or given by the Registrant to
  participants in the Plan covered by this Registration Statement pursuant to Rule 428(b)(1) under
  the Securities Act.
  Item 2.
  Registrant Information and Employee Plan Annual Information
  .
  The written statement required by Item 2 is included in documents sent or given by the
  Registrant to participants in the Plan covered by this Registration Statement pursuant to Rule
  428(b)(1) under the Securities Act.
  Table of Contents
  PART II
  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
  Item 3. Incorporation of Documents by Reference
  .
  The following documents filed by the Registrant with the Commission are incorporated herein by
  reference:
  (1)
  The Registrant's Annual Report
  on Form 10-K for the fiscal year ended December 31, 2006
  filed on March 12, 2007, as amended by Form 10-K/A filed on March 19, 2007 (File No. 000-51711);
  (2)
  The Registrant's Current Report on Form 8-K filed on January 3, 2007 (File No. 000-51711);
  (3)
  The Registrant's Quarterly Report on Form 10-Q/A for the quarter ended September 30, 2006 filed on January 16, 2007 (File No. 000-51711);
  (4)
  The Registrant's Current Report on Form 8-K filed on February 1, 2007 (File No. 000-51711);
  (5)
  The Registrant's Current Report on Form 8-K filed on February 6, 2007 (File No. 000-51711);
  (6)
  The Registrant's Current Report on Form 8-K filed on March 1, 2007 (File No. 000-51711);
  (7)
  The Registrant's Current Report on Form 8-K filed on March 8, 2007 (File No. 000-51711);
  (8)
  The Registrant's Current Report on Form 8-K filed on April 5, 2007 (File No. 000-51711);
  (9)
  The Registrant's Current Report on Form 8-K filed on April 19, 2007 (File No. 000-51711);
  (10)
  The Registrant's Current Report on Form 8-K filed on May 9, 2007 (File No. 000-51711);
  (11)
  The Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2007 filed on May 11, 2007 (File No. 000-51711);
  (12)
  The Registrant's Current Report on Form 8-K filed on May 21, 2007 (File No. 000-51711);
  (13)
  The Registrant's Current Report on Form 8-K filed on June 11, 2007 (File No, 000-51711);
  (14)
  The Registrant's Current Report on Form 8-K filed on June 28, 2007 (File No, 000-51711);
  (15)
  The Registrant's Current Report on Form 8-K filed on July 3, 2007 (File No, 000-51711);
  (16)
  The Registrant's Current Report on Form 8-K filed on July 17, 2007 (File No, 000-51711); and
  (17)
  The Registrant's Quarterly Report on Form 10-Q for the quarter ended June 30, 2007 filed on August 8, 2007 (File No. 000-51711).
  All reports and other documents filed by the Registrant after the date hereof pursuant to
  Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, prior to the filing of
  a post-effective amendment which indicates that all securities offered hereby have been sold or
  which deregisters all securities then remaining unsold, shall be deemed to be incorporated by
  reference herein and to be part
  II-1
  Table of Contents
  hereof from the date of filing of such reports and documents. Any statement contained in a
  document incorporated or deemed to be incorporated by reference herein shall be deemed to be
  modified or superseded for the purposes of this Registration Statement to the extent that a
  statement contained herein or in any other subsequently filed document which also is or is deemed
  to be incorporated by reference herein modifies or supersedes such statement. Any statement so
  modified or superseded shall not be deemed, except as so modified or superseded, to constitute a
  part of this Registration Statement.
  Item 4. Description of Securities
  .
  Not applicable.
  Item 5. Interests of Named Experts and Counsel
  .
  The validity of the issuance of the shares of Common Stock registered under this Registration
  Statement has been passed upon for the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
  P.C. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and members of that firm, their families
  and trusts for their benefit own an aggregate of approximately 13,044 shares of Common Stock of
  the Registrant and options and warrants to purchase 1,000 shares of Common Stock of the
  Registrant.
  Item 6. Indemnification of Directors and Officers
  .
  Incorporated herein by reference from Part II, Item 15 "Indemnification of Directors and
  Officers" of the Registrant's Registration Statement on Form S-3 (File No. 333-141414).
  Item 7. Exemption from Registration Claimed
  .
  Not applicable.
  Item 8. Exhibits
  .
  (4.1)
  Restated Certificate of Incorporation of the Registrant. Filed as Exhibit 3.1 to the
  Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2006, as
  amended (File No. 000-51711) and incorporated herein by reference.
  (4.2)
  Restated By-laws of the Registrant. Filed as Exhibit 3.4 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.3)
  Form of Common Stock Certificate. Filed as Exhibit 4.1 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.4)
  Amended and Restated Investor Rights Agreement, dated as of May 21, 2004. Filed as Exhibit
  4.3 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037)
  and incorporated herein by reference.
  (4.5)
  Form of Common Stock Warrant to Adage Capital Partners, L.P. Filed as Exhibit 4.5 to the
  Registrant's Registration Statement on Form S-3 (File No. 333-141414) and incorporated herein
  by reference.
  (4.6)
  Form of Common Stock Warrant to General Electric Capital Corporation. Filed as Exhibit 4.7
  to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  II-2
  Table of Contents
  (4.7)
  Form of Common Stock Warrant to Oxford Finance Corporation. Filed as Exhibit 4.8 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (4.8)
  Form of Common Stock Warrant to Cystic Fibrosis Foundation Therapeutics, Inc. Filed as
  Exhibit 4.9 to the Registrant's Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.
  (4.9)
  Form of Common Stock Warrant to Transamerica Business Credit Corporation. Filed as Exhibit
  4.10 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037)
  and incorporated herein by reference.
  (4.10)
  Form of Common Stock Warrant to Cowen and Company, LLC. Filed as Exhibit 4.11 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (4.11)
  Form of Series B Preferred Stock Warrant, as amended, together with a schedule of warrant
  holders. Filed as Exhibit 4.12 to the Registrant's Registration Statement on Form S-1, as
  amended (File No. 333-129037) and incorporated herein by reference.
  (4.12)
  Form of Series C Preferred Stock Warrant, together with a schedule of warrant holders.
  Filed as Exhibit 4.13 to the Registrant's Registration Statement on Form S-1, as amended (File
  No. 333-129037) and incorporated herein by reference.
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered. Filed herewith.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit 5).
  (23.2)
  Consent of Deloitte & Touche LLP. Filed herewith.
  (24)
  Power of Attorney to file future amendments (set forth on the signature page of this
  Registration Statement).
  (99.1)
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan, as amended. Filed as Exhibit 10.4 to the Registrant's Annual Report on Form 10-K for
  the fiscal year ended December 31, 2006, as amended (File No. 000-51711) and incorporated
  herein by reference.
  Item 9. Undertakings
  .
  (a)
  The undersigned Registrant hereby undertakes:
  (1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
  (i) To include any prospectus required by Section 10(a)(3) of the Securities
  Act of 1933;
  II-3
  Table of Contents
  (ii) To reflect in the prospectus any facts or events arising after the
  effective date of the Registration Statement (or the most recent post-effective
  amendment thereof) which, individually or in the aggregate, represent a fundamental
  change in the information set forth in the Registration Statement. Notwithstanding
  the foregoing, any increase or decrease in volume of securities offered (if the
  total dollar value of securities offered would not exceed that which was registered)
  and any deviation from the low or high end of the estimated maximum offering range
  may be reflected in the form of prospectus filed with the Commission pursuant to
  Rule 424(b) if, in the aggregate, the changes in volume and price represent no more
  than a 20% change in the maximum aggregate offering price set forth in the
  "Calculation of Registration Fee" table in the effective Registration Statement.
  (iii) To include any material information with respect to the plan of
  distribution not previously disclosed in the Registration Statement or any material
  change to such information in the Registration Statement;
  Provided, however
  , that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
  information required to be included in a post-effective amendment by those paragraphs is
  contained in periodic reports filed with or furnished to the Commission by the Registrant
  pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are
  incorporated by reference in this Registration Statement.
  (2) That, for the purpose of determining any liability under the Securities Act of 1933,
  each such post-effective amendment shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (3) To remove from registration by means of a post-effective amendment any of the securities
  being registered which remain unsold at the termination of the offering.
  (b)
  The undersigned Registrant hereby undertakes that, for purposes of determining any liability
  under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to
  Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by
  reference in this Registration Statement shall be deemed to be a new registration statement
  relating to the securities offered therein, and the offering of such securities at that time
  shall be deemed to be the initial bona fide offering thereof.
  (c)
  Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
  permitted to directors, officers and controlling persons of the Registrant pursuant to the
  foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
  Securities and Exchange Commission such indemnification is against public policy as expressed
  in the Act and is, therefore, unenforceable. In the event that a claim for indemnification
  against such liabilities (other than the payment by the Registrant of expenses incurred or
  paid by a director, officer or controlling person of the Registrant in the successful defense
  of any action, suit or proceeding) is asserted by such director, officer or controlling person
  in connection with the securities being registered, the Registrant will, unless in the opinion
  of its counsel the matter has been settled by controlling precedent, submit to a court of
  appropriate jurisdiction the question whether such indemnification by it is against public
  policy as expressed in the Act and will be governed by the final adjudication of such issue.
  II-4
  Table of Contents
  SIGNATURES
  Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
  has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the undersigned,
  thereunto duly authorized, in Cambridge, Massachusetts on August 8, 2007.
  ALTUS PHARMACEUTICALS INC.
  By:
  /s/ Sheldon Berkle
  Sheldon Berkle
  President and Chief Executive Officer
  POWER OF ATTORNEY
  Each person whose signature appears below constitutes and appoints Sheldon Berkle, Jonathan I.
  Lieber and Bruce A. Leicher, and each of them singly, his true and lawful attorneys-in-fact and
  agents, with full power of substitution and resubstitution in each of them singly, for him and in
  his name, place and stead, and in any and all capacities, to sign any and all amendments (including
  post-effective amendments) to this Registration Statement on Form S-8 of Altus Pharmaceuticals
  Inc., and to file the same, with all exhibits thereto and other documents in connection therewith,
  with the Securities and Exchange Commission, granting to the attorneys-in-fact and agents, and each
  of them, full power and authority to do and perform each and every act and thing requisite or
  necessary to be done in or about the premises, as full to all intents and purposes as he might or
  could do in person, hereby ratifying and confirming all that the attorneys-in-fact and agents or
  any of each of them or their substitute may lawfully do or cause to be done by virtue hereof.
  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
  been signed by the following persons in the capacities and on the dates indicated.
  Signature
  Title
  Date
  /s/ Sheldon Berkle
  President, Chief
  Executive Officer and Director
  August 8, 2007
  Sheldon Berkle
  (principal executive officer)
  /s/ Jonathan I. Lieber
  Vice President, Chief
  Financial Officer and Treasurer
  August 8, 2007
  Jonathan I. Lieber
  (principal financial and accounting officer)
  /s/ John P. Richards
  John P. Richard
  Chairman of the Board
  August 8, 2007
  II-5
  Table of Contents
  Signature
  Title
  Date
  /s/ Stewart Hen
  Stewart Hen
  Director
  August 8, 2007
  /s/ Jonathan S. Leff
  Jonathan S. Leff
  Director
  August 8, 2007
  /s/ Manuel A. Navia, Ph.D.
  Manuel A. Navia, Ph.D.
  Director
  August 8, 2007
  /s/ David D. Pendergast, Ph. D.
  David D. Pendergast, Ph.D.
  Director
  August 8, 2007
  /s/ Harry H. Penner, Jr.
  Harry H. Penner, Jr.
  Director
  August 8, 2007
  /s/ Jonathan D. Root, M.D.
  Jonathan D. Root, M.D.
  Director
  August 8, 2007
  /s/ Michael S. Wyzga
  Michael S. Wyzga
  Director
  August 8, 2007
  II-6
  Table of Contents
  INDEX OF EXHIBITS
  Exhibit
  Number
  Description
  (4.1)
  Restated Certificate of Incorporation of the Registrant. Filed as Exhibit 3.1 to the
  Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2006, as
  amended (File No. 000-51711) and incorporated herein by reference.
  (4.2)
  Restated By-laws of the Registrant. Filed as Exhibit 3.4 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.3)
  Form of Common Stock Certificate. Filed as Exhibit 4.1 to the Registrant's Registration
  Statement on Form S-1, as amended (File No. 333-129037) and incorporated herein by reference.
  (4.4)
  Amended and Restated Investor Rights Agreement, dated as of May 21, 2004. Filed as Exhibit
  4.3 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037)
  and incorporated herein by reference.
  (4.5)
  Form of Common Stock Warrant to Adage Capital Partners, L.P. Filed as Exhibit 4.5 to the
  Registrant's Registration Statement on Form S-3 (File No. 333-141414) and incorporated herein
  by reference.
  (4.6)
  Form of Common Stock Warrant to General Electric Capital Corporation. Filed as Exhibit 4.7
  to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (4.7)
  Form of Common Stock Warrant to Oxford Finance Corporation. Filed as Exhibit 4.8 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (4.8)
  Form of Common Stock Warrant to Cystic Fibrosis Foundation Therapeutics, Inc. Filed as
  Exhibit 4.9 to the Registrant's Registration Statement on Form S-1, as amended (File No.
  333-129037) and incorporated herein by reference.
  (4.9)
  Form of Common Stock Warrant to Transamerica Business Credit Corporation. Filed as Exhibit
  4.10 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037)
  and incorporated herein by reference.
  (4.10)
  Form of Common Stock Warrant to Cowen and Company, LLC. Filed as Exhibit 4.11 to the
  Registrant's Registration Statement on Form S-1, as amended (File No. 333-129037) and
  incorporated herein by reference.
  (4.11)
  Form of Series B Preferred Stock Warrant, as amended, together with a schedule of warrant
  holders. Filed as Exhibit 4.12 to the Registrant's Registration Statement on Form S-1, as
  amended (File No. 333-129037) and incorporated herein by reference.
  II-7
  Table of Contents
  Exhibit
  Number
  Description
  (4.12)
  Form of Series C Preferred Stock Warrant, together with a schedule of warrant holders.
  Filed as Exhibit 4.13 to the Registrant's Registration Statement on Form S-1, as amended (File
  No. 333-129037) and incorporated herein by reference.
  (5)
  Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of shares
  being registered. Filed herewith.
  (23.1)
  Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of
  counsel filed as Exhibit 5).
  (23.2)
  Consent of Deloitte & Touche LLP. Filed herewith.
  (24)
  Power of Attorney to file future amendments (set forth on the signature page of this
  Registration Statement).
  (99.1)
  Altus Pharmaceuticals Inc. Amended and Restated 2002 Employee, Director and Consultant Stock
  Plan, as amended. Filed as Exhibit 10.4 to the Registrant's Annual Report on Form 10-K for
  the fiscal year ended December 31, 2006, as amended (File No. 000-51711) and incorporated
  herein by reference.
  II-8