Datasets:

yashm
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pubmed-bioinformatics-abstracts_all_years

pmid string	title string	abstract string	year string	journal string	source string	slice string
2128846	[The k-locus of human immunoglobulin and its significance for other programs studying the human genome].	A review presented in Moscow on December 4, 1989 at the 5th Engelhardt Memorial Lecture on the occasion of the 30th anniversary of the Engelhardt Institute of Molecular Biology. This article was adapted from another review lecture delivered in September 1989 in (H.G. Zachau/Biol. Chem. Hoppe-Seyler, 1990. V. 371. P. 1-...	1990	Molekuliarnaia biologiia	pubmed	1990
1698801	The cystic fibrosis gene: isolation and significance.	The identification and cloning of the CF gene, which codes for a membrane protein that appears to regulate transmembrane ion transport, may lead to an understanding of the basic defect in the disease and to more effective treatment. More broadly, the cloning of the CF gene provides a fast start in the international eff...	1990	Hospital practice (Office ed.)	pubmed	1990
2218527	Mapping the human genome: current status.	The human genome has already been the subject of extensive research activity even though the Human Genome Project is only just officially starting. This review and the accompanying wall chart attempt to provide an integrated, quantitative, and detailed summary of the status of knowledge on the human genome in mid-1990....	1990	Science (New York, N.Y.)	pubmed	1990
2226409	Internal sequence analysis of proteins separated on polyacrylamide gels at the submicrogram level: improved methods, applications and gene cloning strategies.	The fields of protein chemistry and molecular biology are currently merging for study of biologically relevant events and conditions. To obtain partial sequences of microamounts of protein, efficient integration of high resolution separation and sequencing technologies is required. We report here on improved methods th...	1990	Electrophoresis	pubmed	1990
2379835	Proposal for sequencing DNA using ligation of hexamers to generate sequential elongation primers (SPEL-6).	The efficiency of the directed-priming proposal of Studier [Proc. Natl. Acad. Sci. USA 86 (1989) 6917-1921] can be improved upon by employing a library of less than 4094 hexamers, allowing for the easy construction of all required primers using template-directed automated ligation. This 'top-down' sequencing procedure ...	1990	Gene	pubmed	1990
2181666	Orchestrating the Human Genome Project.	The Human Genome Project is under way. The Department of Energy and the National Institutes of Health are cooperating effectively to develop organizational structures and scientific priorities that should keep the project on schedule and within its budget.	1990	Science (New York, N.Y.)	pubmed	1990
2181665	The human genome project: past, present, and future.	This article presents a short discussion of the development of the human genome program in the United States, a summary of the current status of the organization and administration of the National Institutes of Health component of the program, and some prospects for the future directions of the program and the applicat...	1990	Science (New York, N.Y.)	pubmed	1990
1691007	Reverse genetics and cystic fibrosis.	The protein responsible for cystic fibrosis has been identified using an approach called "reverse" genetics. This approach relies on the chromosomal map position to direct the search for a disease gene, several novel cloning strategies to isolate the gene, and the gene's sequence to define the abnormal protein. Reverse...	1990	American journal of respiratory cell and molecular biology	pubmed	1990
2309696	The human genome project--some implications of extensive "reverse genetic" medicine.	Impressive progress has been made during the past several decades in understanding the pathogenesis of human genetic disease. The tools of molecular biology have allowed the isolation of many disease-related genes by forward and a few by reverse genetics, and the imminent completion of a complete human genetic linkage ...	1990	American journal of human genetics	pubmed	1990
2317378	A two-dimensional acrylamide gel electrophoresis/computer software approach to decoding the human genome.	The human genome sequencing initiative is sure to be an expensive and time-consuming project. To maximize the quality of the initial thrust, it is necessary to concentrate on sequencing those genes that are actively involved in crucial biological processes, both normal and otherwise. To identify the protein products of...	1990	BioTechniques	pubmed	1990
2200458	Nutrition science from vitamins to molecular biology.	Nutrition is a science of great importance. Indeed, unless one studies it, one might be afraid to eat anything, in view of all the scare stories about food. Today is the age of molecular biology and above all of DNA. The human genome project will bring new understanding of genetic diseases, and many of these will be "i...	1990	Annual review of nutrition	pubmed	1990
2192367	Ethical issues in human genetic technology.	The United States and several nations in the developed world have initiated efforts to map and sequence the human genome. The knowledge derived from these efforts will have a profound influence on the practice of medicine. This article reviews the technical developments in the field of human genetics and reviews the et...	1990	Pediatrician	pubmed	1990
11651133	The human genome project and the Catholic Church (1).	The Cathlic Church has not made any formal statements about the Human Genome Project as such. But the present Pope, John Paul II, has commented, albeit very briefly, on various aspects of genetic manipulation. Genetic interventions which are therapeutic (e.g. gene therapy), namely, directed to the correction or amelior...	1991	Journal international de bioethique = International journal of bioethics	pubmed	1991
1781023	The Human Genome Project: misguided science policy.	Genome mapping and sequencing projects are inappropriate and wasteful expenditures of precious research funds. By focusing on the acquisition of nucleotide sequences, the various genome projects emphasize the products of science over the process of science. It is doubtful that much of the resulting information will pro...	1991	Trends in biochemical sciences	pubmed	1991
1781022	The Human Genome Project: creating an infrastructure for biology and medicine.	The Human Genome Project (HGP) is an international effort to map and sequence the human genome. It combines skills from diverse fields of biological and technological research, thus establishing deeper interactions between scientific disciplines. The combination of these skills should stimulate many advances in both pu...	1991	Trends in biochemical sciences	pubmed	1991
1946366	A genomic scanning method for higher organisms using restriction sites as landmarks.	We have developed a powerful genomic scanning method, termed "restriction landmark genomic scanning," that is useful for analysis of the genomic DNA of higher organisms using restriction sites as landmarks. Genomic DNA is radioactively labeled at cleavage sites specific for a rare cleaving restriction enzyme and then s...	1991	Proceedings of the National Academy of Sciences of the United States of America	pubmed	1991
1928094	Eugenics: past, present, and the future.	During the past 20 years there has been a resurgence of interest in the history of the eugenics movements, particularly those of the United States and Germany. Unfortunately, most of these accounts have been published in nonmedical and nongenetic journals, so they are not readily available to geneticists or physicians....	1991	American journal of human genetics	pubmed	1991
1842934	Sequence-tagged site (STS) content mapping of human chromosomes: theoretical considerations and early experiences.	The magnitude of the effort required to complete the human genome project will require constant refinements of the tools available for the large-scale study of DNA. Such improvements must include both the development of more powerful technologies and the reformulation of the theoretical strategies that account for the ...	1991	PCR methods and applications	pubmed	1991
1918207	The human genome initiative: a statement of need.	We may never have a complete understanding of the complex dynamics of the human organism, but we can and should know all our genes and begin to understand their role in the diseases that diminish our lives. A 15-year program has been projected and the specific, quantifiable goals in mapping and sequencing are outlined....	1991	Hospital practice (Office ed.)	pubmed	1991
1918195	DNA sequencing, today and tomorrow.	When we have the completed sequence, by about the year 2000, it will be possible to search more efficiently for genes involved in multifactorial diseases, including various cancers. With the genome sequenced and the full complement of genes identified, basic questions about our common biology will become central issues...	1991	Hospital practice (Office ed.)	pubmed	1991
1895475	The human genome project. Prospects and implications for clinical medicine.	The recently initiated human genome project is a large international effort to elucidate the genetic architecture of the genomes of man and several model organisms. The initial phases of this endeavor involve the establishment of rough blueprints (maps) of the genetic landscape of these genomes, with the long-term goal...	1991	JAMA	pubmed	1991
1925562	Large-scale and automated DNA sequence determination.	DNA sequence analysis is a multistage process that includes the preparation of DNA, its fragmentation and base analysis, and the interpretation of the resulting sequence information. New technological advances have led to the automation of certain steps in this process and have raised the possibility of large-scale DNA...	1991	Science (New York, N.Y.)	pubmed	1991
11653952	Implications of the human genome initiative for the primary care physician.	... Despite the need for physicians to be knowledgeable about and open to advances in genetic technology, little is known about the level of preparedness of primary care physicians to offer new genetic tests. Evidence suggests that several barriers exist to physicians adopting genetic tests. These include lack of knowl...	1991	Bioethics	pubmed	1991
11653948	Prospects for "genetic therapy" -- can a person benefit from being altered?	Mapping the human genome is an immense project with numerous objectives. Indeed, it is likely that some of its most important ramifications and applications remain as yet unglimpsed. All we can presently attempt is to focus on some of the more obvious possibilities and prepare for the problems already looming on our ho...	1991	Bioethics	pubmed	1991
11645703	Human genome research in an interdependent world.	This has been the year of agenda-setting conferences for the ambitious ELSI (ethical, legal and social issues) program of the Human Genome Project (HGP). But of the dozen or more major meetings of this sort held across the country, the one held at the National Institutes of Health (NIH) in Bethesda, MD, June 2-4, 1991,...	1991	Kennedy Institute of Ethics journal	pubmed	1991
1865911	Solid-phase gene assembly.	New technologies for multiple chemical synthesis of oligonucleotides and stepwise hybridization on a solid-phase support enable the rapid and cost-effective preparation of long duplex DNA regions. Will these new technologies usher in a new era in protein engineering?	1991	Nature	pubmed	1991
1683043	[Genome analysis--current status of knowledge and future perspectives].	The rapid recent progress in molecular biology has placed the complete analysis of the human genome near at hand. This analysis of the human genome is not only restricted to the mapping, i.e. the localization of the genes on the chromosomes, but also involves the complete sequence analysis of the human DNA. Combined wi...	1991	Versicherungsmedizin	pubmed	1991
11659342	Should ethical concerns regulate science? The European experience with the human genome project: a report from Denmark.	... The allocation of resources can indirectly control science by defining areas undesirable for research from the point of view of society. In the United States federal funds are not available for research on human embryos. The European experience represents a new approach to control of scientific research. The projec...	1991	Bioethics	pubmed	1991
11659341	Mapping the human genome: some thoughts for those who say "There should be a law on it.	... It appears from this discussion that the most effective method of regulating the problems that may arise from the human genome project is to concentrate, not on the research involved in the project, but rather on the uses that may be made of the information gained from it. Furthermore, there is already a good deal ...	1991	Bioethics	pubmed	1991
11659339	Whose genome project?	The human genome project is a multinational project aimed at obtaining a detailed map and a complete DNA sequence of the human genome. It will have many scientific, medical, economic, ethical, legal, and social implications. A fundamental question to ask is "Whose genome project is it?" We can answer this question from...	1991	Bioethics	pubmed	1991
11654898	The Human Genome Project in the United States: a perspective on the commercial, ethical, legislative and health care issues.	The Human Genome Project represents a government supported effort to map and sequence the human genome. Governmental support for the Project should include increased emphasis on grants and contracts to industry. This is particularly true for small highly innovative biotechnology companies that can rapidly integrate and...	1991	Journal international de bioethique = International journal of bioethics	pubmed	1991
2047873	Complementary DNA sequencing: expressed sequence tags and human genome project.	Automated partial DNA sequencing was conducted on more than 600 randomly selected human brain complementary DNA (cDNA) clones to generate expressed sequence tags (ESTs). ESTs have applications in the discovery of new human genes, mapping of the human genome, and identification of coding regions in genomic sequences. Of...	1991	Science (New York, N.Y.)	pubmed	1991
2047872	Recent advances in the polymerase chain reaction.	The polymerase chain reaction (PCR) has dramatically altered how molecular studies are conducted as well as what questions can be asked. In addition to simplifying molecular tasks typically carried out with the use of recombinant DNA technology, PCR has allowed a spectrum of advances ranging from the identification of ...	1991	Science (New York, N.Y.)	pubmed	1991
1840885	Progress towards completing the human linkage map.	Genetic linkage maps order polymorphic loci (markers) along a chromosome and provide a measure of distance that is an inherently statistical measure of the frequency of meiotic recombination and has no simple relationship to DNA length in Mb. Few accurate and dense maps now exist. Maps with markers spaced every 2 cM pr...	1991	Current opinion in genetics & development	pubmed	1991
1840881	Physical mapping of the human genome by pulsed field gel analysis.	Detailed physical maps of large regions of the human genome are important for locating and cloning genes responsible for human hereditary diseases, as well as for obtaining a more detailed understanding of chromosome structure and evolution. Pulsed field gel electrophoresis provides one method for generating physical m...	1991	Current opinion in genetics & development	pubmed	1991
1840870	Genome mapping databases: data acquisition, storage and access.	The introduction of the genome database to the human gene mapping community in September 1990 heralded the advent of a new generation of databases to serve the needs of the human genome initiative over the coming years. The databases will act as a fulcrum around which the activities of the human genome initiative can b...	1991	Current opinion in genetics & development	pubmed	1991
1840868	Mammalian genome mapping: lessons and prospects.	The recent emphasis on human genome mapping has stimulated the development of gene maps in close to thirty mammalian species. Animal gene maps provide an invaluable resource for genetic analysis and manipulation of phenotypic characters, as well as a retrospective glimpse at the patterns and processes of genome evoluti...	1991	Current opinion in genetics & development	pubmed	1991
1925538	Electronic data publishing and GenBank.	GenBank, the national repository for nucleotide sequence data, has implemented a new model of scientific data management, which we term electronic data publishing. In traditional publishing, both scientific conclusions and supporting data are communicated via the printed page, and in electronic journal publishing, both...	1991	Science (New York, N.Y.)	pubmed	1991
2023938	Theoretical analysis of a physical mapping strategy using random single-copy landmarks.	An approach to physical mapping is analyzed here. This procedure consists of fingerprinting random clones with single-copy landmarks extracted randomly from a region of interest. Results are presented in terms of number of contigs (sets of overlapping clones), number of isolated clones, average length of a contig, and ...	1991	Proceedings of the National Academy of Sciences of the United States of America	pubmed	1991
1857191	Searching gene and protein sequence databases.	A large-scale effort to map and sequence the human genome is now under way. Crucial to the success of this research is a group of computer programs that analyze and compare data on molecular sequences. This article describes the classic algorithms for similarity searching and sequence alignment. Because good performanc...	1991	M.D. computing : computers in medical practice	pubmed	1991
2062102	On the prevalence of transcriptional regions in human genomic DNA.	The dinucleotide sequences TpA and CpG are differentially expressed in transcribed vs. non-transcribed portions of the human genome (Beutler et al., 1989, Proc. natn. Acad. Sci. U.S.A. 86, 192-196). This fact is exploited here to estimate the total number of transcriptional regions in human genomic DNA.	1991	Journal of theoretical biology	pubmed	1991
2038240	A clinical molecular scanner: the Melanie project.	We developed an expert system to analyze and interpret protein maps. This system, Melanie (medical electrophoresis analysis interactive expert), can distinguish between normal and cirrhotic liver and identify various types of cancer on the basis of protein patterns in biopsy specimens. Our findings suggest that some di...	1991	M.D. computing : computers in medical practice	pubmed	1991
2011524	A test case for physical mapping of human genome by repetitive sequence fingerprints: construction of a physical map of a 420 kb YAC subcloned into cosmids.	A rapid and safe method of Yeast Artificial Chromosome (YAC) physical mapping by cosmid 'fingerprinting' is presented. YACs are subcloned into cosmids which are prepared without previous separation of cloned DNA from host DNA. Groups of overlapping clones are detected according to their restriction fragments size and i...	1991	Nucleic acids research	pubmed	1991
1992162	Mapping using unique sequences.	Theoretical predictions are given for the progress expected, when mapping DNA by identifying clones containing specific unique sequences. Progress is measured in three ways; however, all results depend on (dimensionless counterparts of) the number of clones and the number of unique sequences used. Furthermore, the effe...	1991	Journal of molecular biology	pubmed	1991
1991595	Origins of the Human Genome Project.	The Human Genome Project has become a reality. Building on a debate that dates back to 1985, several genome projects are now in full stride around the world, and more are likely to form in the next several years. Italy began its genome program in 1987, and the United Kingdom and U.S.S.R. in 1988. The European communiti...	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1991587	Human genome efforts in Japan.	Some project-oriented biosciences have been promoted cooperatively by three governmental agencies in Japan: the Ministry of Education, Science and Culture, the Ministry of Health and Welfare, and the Science and Technology Agency. All three agencies have increased their budgetary requests for human genome analyses for ...	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1991586	European approach to the Human Gene Project.	In the history of gene mapping, which extends through most of the present century, Europe has played an important role. This has continued during the evolution of the 10 International Human Gene Mapping Workshops that have been held in seven different countries since 1973. Nationally coordinated programs have been a re...	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1991584	Applications of the polymerase chain reaction to genome analysis.	The objectives of the Human Genome Project are to create high-resolution genetic and physical maps, and ultimately to determine the complete nucleotide sequence of the human genome. The result of this initiative will be to localize the estimated 50,000-100,000 human genes, and acquire information that will enable devel...	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1991583	DNA sequencing: present limitations and prospects for the future.	As the human genome program gets under way, we examine the progress made since the first human genome meeting in Santa Cruz in 1985. The lessons of the last 5 years demonstrate that progress has been much slower than anticipated. The new technology being developed in 1985 was fluorescent sequencing and multiplexing. Th...	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1991581	The Human Genome Project: a paradigm for information management in the life sciences.	The major product of the Human Genome Project will be a series of linked data sets containing the genetic and physical location of all genes on each chromosome, plus the complete nucleotide sequence of the genome for humans and several model organisms. Here we summarize the current status of attempts to collect, analyz...	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1991580	Current trends in mapping human genes.	The human is estimated to have at least 50,000 expressed genes (gene loci). Some information is available concerning about 5000 of these gene loci and about 1900 have been mapped, i.e., assigned to specific chromosomes (and in most instances particular chromosome regions). Progress has been achieved by a combination of...	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1897258	Legal aspects of genetic information.	The federally funded Human Genome Initiative will lead to the development of new capabilities to learn about an individual's genetic status. Legal issues are raised concerning patients' and other parties' access to that information. This article discusses the effect of existing statutes and case law on three pivotal qu...	1991	The Yale journal of biology and medicine	pubmed	1991
1846833	New techniques for physical mapping of the human genome.	We describe improvements in techniques and strategies used for making maps of the human genome. The methods currently used are changing and evolving rapidly. Today's techniques can produce ordered arrays of DNA fragments and overlapping sets of DNA clones covering extensive genomic regions, but they are relatively slow...	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1846832	Molecular studies of human genetic disease.	A wide variety of techniques are available for detecting disease-causing mutations within human genes; this report provides a brief review of such procedures. Good communication and exchange of materials between the clinical genetics field and the Human Genome Initiative will benefit both.	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1836362	Selective abortion and gene therapy: reflections on human limits.	The potential impact of the Human Genome Project on selective abortion is considered here, as is human gene therapy. Themes of emphasis are broadly humanistic: human suffering, contingency, and perfection. The chief concerns of the article lie with selective abortion for less than serious reasons, and with the importan...	1991	Human gene therapy	pubmed	1991
1825074	Ethical issues in human genome research.	In addition to provocative questions about science policy, research on the human genome will generate important ethical questions in at least three categories. First, the possibility of greatly increased genetic information about individuals and populations will require choices to be made about what that information sh...	1991	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	pubmed	1991
1369116	The human genetic map.	The introduction of new technology and increased effort from around the world is driving the completion of the human gene map. In parallel with the creation of the map, we are beginning to see the bio-medical benefits that are a direct consequence of learning more about our own genome.	1992	Current opinion in biotechnology	pubmed	1992
1445778	The human genome project and clinical medicine.	Genetic research has already begun to pay clinical dividends, as investigators have successfully isolated disease genes, including those responsible for Duchenne muscular dystrophy, cystic fibrosis, and the fragile X syndrome. This last disorder appears to be associated with the progressive amplification of a short, re...	1992	Oncology (Williston Park, N.Y.)	pubmed	1992
1436050	The 'far east' of biological ethics.	The ethics of biological research, and its general impact, are hotly debated in the West. Japanese silence on the issues is counterproductive. Will the Human Genome Project provide the catalyst for change?	1992	Nature	pubmed	1992
11652093	Rationale for an integrated approach to genetic epidemiology.	Genetic knowledge is now in the public domain and its interpretation by the media and the citizens brings the issues into the public forum of discussion for the necessary ethical, legal and socio-cultural evaluation of its application. Science is being perceived by some as dangerous and as requiring international regul...	1992	Bioethics	pubmed	1992
1517727	The implications of the Human Genome Project for family practice.	The Human Genome Project is an international effort to map and sequence the human genome. The information it will generate has been referred to by some as the "new anatomy," and may play an important role in the future of medicine. However, as with any new technological advancement, the outcome of the Human Genome Proj...	1992	The Journal of family practice	pubmed	1992
1502556	Genes, patents, and product development.	In the past year, the National Institutes of Health (NIH) has filed patent applications on more than 2750 partial complementary DNA sequences of unknown function. The rationale for the filings--that patent protection may be necessary to ensure that private firms are willing to invest in developing related products--res...	1992	Science (New York, N.Y.)	pubmed	1992
1431656	The Human Genome Project and the social contract: a law policy approach.	For the first time in history, genetics will enable science to completely identify each human as genetically unique. Will this knowledge reinforce the trend for more individual liberties or will it create a 'brave new world'? A law policy approach to the problems raised by the human genome project shows how far our dem...	1992	The Journal of medicine and philosophy	pubmed	1992
11652054	First fruits: genetic screening.	[C]ritics of modern obstetric practices have taken note of the ways in which increased diagnostic surveillance can change the character and mood of pregnancy, and they have urged special caution about increased prenatal genetic testing. This paper explores these issues and suggests the need for national standards artic...	1992	The Hastings Center report	pubmed	1992
11652052	Genetic secrets: social issues of medical screening in a genetic age.	In the 1990s, as the multi-billion-dollar Human Genome Project makes more and more genetic information available, we would do well to look closely at the social context of power dynamics, control, and economic interests within which that information will be used. Let us consider four specific questions. How does social...	1992	The Hastings Center report	pubmed	1992
1449237	Algorithms for a location database.	The algorithms that drive the ldb location database are described. The program captures data on genetic and physical maps and combines information from different sources into a summary map. To assure portability it was developed in Fortran on a SUN SPARCStation under Unix. The algorithms, which combine rule-based seria...	1992	Annals of human genetics	pubmed	1992
1621744	Gene therapy strategies for pulmonary disease.	The two most common hereditary lung disorders in Caucasians, alpha 1-antitrypsin (alpha 1-AT) deficiency and cystic fibrosis, have their major clinical manifestations in the lung. Rapid advances in biotechnology have resulted in a variety of gene therapy strategies for the potential treatment of these disorders. Three ...	1992	The American journal of medicine	pubmed	1992
1504612	CEPH maps.	There are CEPH genetic maps on each homologous human chromosome pair. Genotypes for these maps have been generated in 88 laboratories that receive DNA from a reference panel of large nuclear pedigrees/families supplied by the Centre d'Etude du Polymorphisme Humain. These maps serve as useful tools for the localization ...	1992	Current opinion in genetics & development	pubmed	1992
1504611	The human genetic map.	The introduction of new technology and increased effort from around the world is driving the completion of the human gene map. In parallel with the creation of the map, we are beginning to see the biomedical benefits that are a direct consequence of learning more about our own genome.	1992	Current opinion in genetics & development	pubmed	1992
1502543	Human genome project.	Genome n. [gene plus chromosome] the complete set of chromosomes containing all of the genes of an organism. For man this set of 46 per cell stretches to a 6 foot strand of DNA. Within this string of 3 billion nucleotide bases are 100,000 genes. Utilizing a 4 letter alphabet (Adenine, Guanine, Cytosine, Thymine), genes...	1992	South Dakota journal of medicine	pubmed	1992
1591610	The UK Human Genome Mapping Project online computing service.	This paper presents an overview of computing and networking facilities developed by the Medical Research Council to provide online computing support to the Human Genome Mapping Project (HGMP) in the UK. The facility is connected to a number of other computing facilities in various centres of genetics and molecular biol...	1992	Computer applications in the biosciences : CABIOS	pubmed	1992
1595382	[Ethical and social issues on the human genome analysis].	The modern technologies for human genome analysis raise a variety of ethical and social questions. The pre-symptomatic diagnostic of diseases of late expression is becoming possible for a rapidly increasing number of situations. The use of that knowledge by employers, insurance companies, schools, and society in genera...	1992	Acta medica portuguesa	pubmed	1992
1559700	Chromosomal assignment of 46 brain cDNAs.	Expressed sequence tags (ESTs) have been obtained from several hundred brain cDNAs as an initial effort to characterize expressed brain genes. These ESTs will become tools for human genome mapping and they will also provide candidate causative genes for inherited disorders affecting the central nervous system. We have ...	1992	Genomics	pubmed	1992
10118257	Gene mapping: is fortune or misfortune to be found?	An attempt to map the entire human genetic code, collectively referred to as the human genome, raises expectations of medical advances as well as moral dilemmas.	1992	Journal of AHIMA	pubmed	1992
1636478	A human genome analysis system (HUGA-I) developed in Japan.	A part of the Japanese human genome project has resulted in the development of a world original human genome analysis system. Circumstances of the project, objective, design concept, and constitution of the system are described in the paper.	1992	Advances in biochemical engineering/biotechnology	pubmed	1992
1555021	Government and science: stimulation or inhibition.	The Human Genome Project will target an important set of scientific issues. Moreover, the Human Genome Project will address the ethical issues that arise from better understanding of human genetic make-up. Finally, and the focus of my talk today, a series of challenging policy and institutional issues surround biotechn...	1992	Bulletin of the New York Academy of Medicine	pubmed	1992
1367939	An artificial intelligence approach to DNA sequence feature recognition.	The ultimate goal of the Human Genome project is to extract the biologically relevant information recorded in the estimated 100,000 genes encoded by the 3 x 10(9) bases of the human genome. This necessitates development of reliable computer-based methods capable of analysing and correctly identifying genes in the vast ...	1992	Trends in biotechnology	pubmed	1992
8254856	National policy development for the clinical application of genetic diagnostic technologies. Lessons from cystic fibrosis.	In recognition of the earlier experiences with genetic diagnostic services and in anticipation of a greater potential for genetic testing for presymptomatic disease and disease susceptibility, this article provides an analysis of policy development for cystic fibrosis carrier screening. The deficiencies of relying on a...	1993	JAMA	pubmed	1993
8276271	Patenting cDNA 1993: efforts and happenings (Human Genome Project; NIH: US PTO; onco-mouse; European Patents).	The National Institute of Health (NIH) and Dr. J.C. Venter applied for patents for the sequences of cDNA fragments from a brain library. The scientific community objected strenuously on emotional grounds. The NIH argues that these sequences might never be patentable even when completed. The issue became an internationa...	1993	Gene	pubmed	1993
8276268	cDNA analyses in the human genome project.	The ultimate goal of the human genome project is to decode all the genetic information carried in the genome. Towards this goal, the physical structure of the genome, as well as the functional aspects of the genome, must be understood. We initiated a cDNA project to collect the 'expression profiles' of all human genes,...	1993	Gene	pubmed	1993
8186292	Genetic information and health insurance. Report of the Task Force on Genetic Information and Insurance. NIH/DOE Working Group on Ethical, Legal, and Social Implications of Human Genome Research.	One of the ironies in the current health care coverage crisis is that developing more accurate biomedical information could make things worse rather than better. In the current American health care system, information about an individual's risk of disease plays a crucial role for many people in determining access to he...	1993	Human gene therapy	pubmed	1993
8112059	LODVIEW: a computer program for the graphical evaluation of lod score results in exclusion mapping of human disease genes.	For linkage analysis projects aimed at mapping hereditary disease genes in humans, hundreds of highly polymorphic microsatellite markers which can be typed by PCR (PCR markers) have become available. With this technical improvement, the availability of a technique allowing for transparency in the handling of rapidly ge...	1993	Computers and biomedical research, an international journal	pubmed	1993
10146565	The Human Genome Project and health behavior and health education research.	The Human Genome Project (HGP) is a multinational initiative to map and sequence the human genome. This major biological research effort, estimated to take 15 years and cost $3 billion, should have significant implications for public health generally, and for health behavior and health education research in particular....	1993	Health education research	pubmed	1993
8263713	Molecular biology and life science.	Molecular biology has made the transition from phase 1, dealing with prokaryotic genes and DNA, to phase 2, dealing with genes of eukaryotic multicellular organisms. This transition came about because of the DNA technology that has evolved since the early 1970s. Now we are at the beginning of the transition to phase 3,...	1993	Journal of periodontal research	pubmed	1993
8237907	The Human Genome Project and the future of medicine.	The Human Genome Project is an international research effort the goal of which is to analyze the structure of human DNA and to determine the location of the estimated 100,000 human genes. Another component of the program is to analyze the DNA of a set of nonhuman model organisms to provide comparative information that ...	1993	American journal of diseases of children (1960)	pubmed	1993
8124493	Primary care and the human genome project. Into the breach.	The Human Genome Project potentially may change how medical care is conceptualized and delivered. Screening for gene mutations in the future will likely be more precise, allowing screening for a much wider scope of diseases. The demand for this testing will thereby create stresses on the health care system that may req...	1993	Archives of family medicine	pubmed	1993
8124491	Ethical and practical implications of the human genome initiative for family medicine.	Major advances in predictive genetic testing resulting from the Human Genome Initiative could change significantly the routine practice of family medicine. Family physicians should be aware that increased genetic information may affect patients' abilities to acquire and maintain insurance and employment and that intere...	1993	Archives of family medicine	pubmed	1993
7510179	[Molecular diagnosis of genetic diseases in Russia: current status and perspectives].	The paper reviews the current molecular diagnosis of common socially significant inherited diseases such as cystic fibrosis, Duchenne muscular dystrophy, hemophilia A and B, phenylketonuria. It also provides basic results of prenatal diagnosis of these diseases and detection of their heterozygous carriage in Saint Pete...	1993	Vestnik Rossiiskoi akademii meditsinskikh nauk	pubmed	1993
8401692	Quantum leaps. A look at the health care delivery system in twenty years.	What will the health care delivery system of the future look like? Though 20 years from now may seem like a long way off for some people, health care experts are already seeing the seeds of future realities begin to sprout. But the new era of delivery also will involve many features now just barely imaginable, includin...	1993	Hospitals & health networks	pubmed	1993
8211130	A genetic linkage map of the mouse: current applications and future prospects.	Technological advances have made possible the development of high-resolution genetic linkage maps for the mouse. These maps in turn offer exciting prospects for understanding mammalian genome evolution through comparative mapping, for developing mouse models of human disease, and for identifying the function of all gen...	1993	Science (New York, N.Y.)	pubmed	1993
8411697	[Structural analysis of human genome by YAC technologies].	A method for construction of YAC (Yeast Artificial Chromosome) libraries with large inserts has been developed and promoted the ongoing project of human genome. Isolation by PCR screening charges the YAC clone with a unique tag of a pair of PCR primers at the defined chromosome site (Sequence Tagged Sites; STS). Curren...	1993	Nihon rinsho. Japanese journal of clinical medicine	pubmed	1993
7764291	Some ethical issues in genetic medicine.	The world-wide project to map the human genome contains great promise for identifying the genetic determinants of disease and the development of gene therapies. However, at the same time it creates extensive possibilities for breaches of human rights, for the development of social policies of a eugenic kind and for the...	1993	Australasian biotechnology	pubmed	1993
8399493	Discussion points to consider in research related to the human genome.	The advances in DNA technology and molecular genetics, spurred by the Human Genome Project, have created new challenges for human subjects research and the system of institutional review board (IRB) review. The populations to be studied are vulnerable because of genetic diseases or risk for them; until now, IRB review ...	1993	Human gene therapy	pubmed	1993
8346237	Integration of gene maps: chromosome 21.	Physical, cytogenetic, and genetic data including microsatellite markers and a covering sequence-tagged site (STS) map have been entered into a location database and integrated into a summary map that subsumes a composite physical location, sex-specific genetic locations, cytogenetic and regional assignments, mouse hom...	1993	Proceedings of the National Academy of Sciences of the United States of America	pubmed	1993
8210778	Human Genome Project and cancer: the ethical implications for clinical practice.	The Human Genome Project has far-reaching implications for the entire spectrum of cancer care. An understanding of fundamental gene biology clarifies the role of genetics in cancer causation. The scientific advances of genetic screening for cancers have also given rise to problems such as employment and insurance discr...	1993	Seminars in oncology nursing	pubmed	1993
8374584	The GDB Human Genome Data Base: a source of integrated genetic mapping and disease data.	The GDB Human Genome Data Base refers collectively to GDB and OMIM, Online Mendelian Inheritance in Man. GDB and OMIM are linked databases that provide an international repository for information generated by the Human Genome Initiative. GDB contains human gene mapping data, while OMIM offers the text of Dr. Victor A. ...	1993	Bulletin of the Medical Library Association	pubmed	1993
8374581	Translating the genetic library: the goals, methods, and applications of the Human Genome Project.	The information produced by the Human Genome Project will have profound effects on the medical community, biotechnology companies, research scientists, and others. The ultimate goal of the project is to locate the approximately 100,000 genes that contain the instructions for creating a human being. Once these genes are...	1993	Bulletin of the Medical Library Association	pubmed	1993
7513103	Child health, the genome project and phenylketonuria.	Child health and life expectancy improved together in many societies in the 20th century. As the incidence of diseases with major extrinsic causes declined, the heritability of disease as a whole increased. Accordingly, the genetic (intrinsic) causes of disease have become important. The genome project is an internatio...	1993	The Turkish journal of pediatrics	pubmed	1993
8506271	The human genome project.	The Human Genome Project in the United States is now well underway. Its programmatic direction was largely set by a National Research Council report issued in 1988. The broad framework supplied by this report has survived almost unchanged despite an upheaval in the technology of genome analysis. This upheaval has prima...	1993	Proceedings of the National Academy of Sciences of the United States of America	pubmed	1993
8489332	Ethics and the Human Genome Project.	This article provides an overview of ethical issues in genetic testing and screening as they are currently considered in relationship to the Human Genome Project. Previous landmark reports and policy recommendations on genetic testing and screening are briefly described. The goals and research interests of the joint Na...	1993	Archives of pathology & laboratory medicine	pubmed	1993

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PubMed Bioinformatics Abstracts — All Years

A curated dataset of bioinformatics research abstracts fetched from PubMed via the NCBI Entrez API, covering publications from 1990 through 2026. Designed for LLM fine-tuning, biomedical NLP, and scientific text analysis.

Curated by: Dr. Yash M Gupta Pipeline: yashmgupta/pubmed-bioinformatics-abstracts

Intended Use

Fine-tuning large language models (LLMs) on biomedical / bioinformatics domain text.

Data Fields

Column	Type	Description
`pmid`	string	PubMed ID
`title`	string	Article title
`abstract`	string	Full abstract text
`year`	string	Publication year
`journal`	string	Journal name
`doi`	string	DOI (if available)
`source`	string	Always "pubmed"
`slice`	string	Time slice used during collection

Only articles with non-empty abstracts are included.

Collection Method

Source: NCBI PubMed via Entrez E-utilities (Biopython)
Query: bioinformatics[MeSH Terms] AND hasabstract[text] AND journal article[pt]
Date range: 2017–2019 (date of publication)
Filters: Only articles with abstracts; journal articles only

License

This dataset is released under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) license.

The abstracts themselves are sourced from PubMed/MEDLINE and are subject to the NLM Terms and Conditions. Users must comply with NCBI/NLM usage policies when redistributing or using this data.

Citation

If you use this dataset, please cite:

@dataset{gupta_2026_pubmed_bioinformatics_all_years,
  author       = {Gupta, Yash M},
  title        = {PubMed Bioinformatics Abstracts -- All Years},
  year         = {2026},
  publisher    = {Hugging Face},
  url          = {https://huggingface.co/datasets/yashm/pubmed-bioinformatics-abstracts_all_years}
}

Please also cite the original data source:

Sayers EW, Bolton EE, Brister JR, et al. Database resources of the National Center for Biotechnology Information. Nucleic Acids Research. 2022;50(D1):D13–D25. doi:10.1093/nar/gkab1112

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