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Now, an interesting complement to the TIR-s-SNOM approach is that reported in PNAS by Zhao et al. (1), and previously by Khatib et al. (17), that builds off the concept of creating a sealed sample chamber that is transparent to IR radiation and which enables s-SNOM measurements (nano-FTIR) (18).
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1025
In this approach, the chamber containing the sample and fluid media is sealed from air by a graphene membrane, with the SPM tip scanning the graphene membrane from the air side.
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This means that the time required to acquire a complete dataset (spectra + AFM image) may be substantial and could, in fact, require rescanning the sample to independently acquire the AFM dataset.
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